STAT6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.61977305
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.61977305
3antigen processing and presentation of endogenous antigen (GO:0019883)5.45334842
4positive regulation of gamma-delta T cell activation (GO:0046645)4.96387370
5detection of other organism (GO:0098543)4.52467032
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.50619859
7detection of bacterium (GO:0016045)4.45649574
8regulation of gamma-delta T cell differentiation (GO:0045586)4.00453722
9antigen processing and presentation via MHC class Ib (GO:0002475)3.90925091
10detection of external biotic stimulus (GO:0098581)3.79144674
11regulation of gamma-delta T cell activation (GO:0046643)3.77240216
12regulation of B cell receptor signaling pathway (GO:0050855)3.73176152
13negative regulation of lymphocyte mediated immunity (GO:0002707)3.65895802
14positive regulation of interferon-alpha production (GO:0032727)3.63902988
15positive regulation of B cell differentiation (GO:0045579)3.62195109
16regulation of interleukin-12 biosynthetic process (GO:0045075)3.54973300
17germinal center formation (GO:0002467)3.52052797
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.49862596
19regulation of interferon-alpha production (GO:0032647)3.45638738
20detection of molecule of bacterial origin (GO:0032490)3.41080557
21regulation of interferon-beta biosynthetic process (GO:0045357)3.34637974
22negative regulation of leukocyte mediated immunity (GO:0002704)3.34158908
23negative regulation of T cell mediated immunity (GO:0002710)3.30753632
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.30535920
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.30535920
26modulation by symbiont of host immune response (GO:0052553)3.30535920
27positive regulation by symbiont of host defense response (GO:0052509)3.30535920
28modulation by symbiont of host defense response (GO:0052031)3.30535920
29modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.30535920
30detection of biotic stimulus (GO:0009595)3.28627763
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.21929446
32response to host immune response (GO:0052572)3.21929446
33regulation of B cell differentiation (GO:0045577)3.20524175
34neutrophil activation involved in immune response (GO:0002283)3.20206206
35positive thymic T cell selection (GO:0045059)3.20112710
36negative thymic T cell selection (GO:0045060)3.19952266
37immunoglobulin mediated immune response (GO:0016064)3.13599262
38response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.12460612
39response to host (GO:0075136)3.12460612
40response to host defenses (GO:0052200)3.12460612
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.12221006
42regulation of tolerance induction (GO:0002643)3.12028555
43negative T cell selection (GO:0043383)3.11301329
44regulation of mast cell degranulation (GO:0043304)3.10950018
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.10819249
46leukocyte aggregation (GO:0070486)3.05175863
47negative regulation of cell killing (GO:0031342)3.02586481
48negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02586481
49positive regulation of antigen processing and presentation (GO:0002579)3.02288397
50NIK/NF-kappaB signaling (GO:0038061)2.99814086
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98627849
52cellular response to interleukin-15 (GO:0071350)2.95676933
53response to type I interferon (GO:0034340)2.94336020
54positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92503406
55regulation of leukocyte degranulation (GO:0043300)2.92069430
56regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91256846
57response to muramyl dipeptide (GO:0032495)2.91254255
58cellular response to type I interferon (GO:0071357)2.89641162
59type I interferon signaling pathway (GO:0060337)2.89641162
60negative regulation of innate immune response (GO:0045824)2.88552866
61regulation of T-helper 2 cell differentiation (GO:0045628)2.87390789
62positive regulation of natural killer cell differentiation (GO:0032825)2.85265518
63macrophage activation (GO:0042116)2.84462739
64regulation of T cell tolerance induction (GO:0002664)2.82466743
65cellular response to zinc ion (GO:0071294)2.80863012
66interferon-gamma-mediated signaling pathway (GO:0060333)2.80729520
67Arp2/3 complex-mediated actin nucleation (GO:0034314)2.80564587
68regulation of mast cell activation involved in immune response (GO:0033006)2.80226951
69production of molecular mediator involved in inflammatory response (GO:0002532)2.79710367
70mannose metabolic process (GO:0006013)2.79526328
71macrophage activation involved in immune response (GO:0002281)2.76166028
72B cell receptor signaling pathway (GO:0050853)2.76116403
73cellular extravasation (GO:0045123)2.75644264
74microglial cell activation (GO:0001774)2.75351385
75response to peptidoglycan (GO:0032494)2.74991681
76regulation of alpha-beta T cell proliferation (GO:0046640)2.73598772
77positive regulation of tolerance induction (GO:0002645)2.73116246
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71019846
79positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.70576908
80regulation of T cell mediated cytotoxicity (GO:0001914)2.70182313
81myeloid dendritic cell activation (GO:0001773)2.69312436
82negative regulation of T-helper cell differentiation (GO:0045623)2.69040042
83negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.69040042
84thymic T cell selection (GO:0045061)2.67791748
85regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67644519
86respiratory burst (GO:0045730)2.67252749
87negative regulation of phagocytosis (GO:0050765)2.67251333
88regulation of natural killer cell mediated immunity (GO:0002715)2.66248870
89regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.66248870
90regulation of cholesterol storage (GO:0010885)2.63235023
91negative regulation of cytokine production involved in immune response (GO:0002719)2.63131541
92positive regulation of type 2 immune response (GO:0002830)2.62218536
93negative regulation of granulocyte differentiation (GO:0030853)2.61790272
94leukocyte cell-cell adhesion (GO:0007159)2.61587040
95pinocytosis (GO:0006907)2.60967445
96interferon-gamma production (GO:0032609)2.60913873
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59659651
98response to interleukin-15 (GO:0070672)2.58913115
99negative regulation of interleukin-12 production (GO:0032695)2.57900496
100regulation of antigen processing and presentation (GO:0002577)2.57877653
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57568994
102positive regulation of interferon-beta production (GO:0032728)2.55561184
103myeloid dendritic cell differentiation (GO:0043011)2.55451103
104regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.55382857
105regulation of response to interferon-gamma (GO:0060330)2.55312441
106neutrophil activation (GO:0042119)2.54978997
107regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.54018606
108T cell migration (GO:0072678)2.53447123
109B cell mediated immunity (GO:0019724)2.52208478
110negative regulation of erythrocyte differentiation (GO:0045647)2.52007969
111tolerance induction (GO:0002507)2.52001840
112cellular response to exogenous dsRNA (GO:0071360)2.50934524
113hepatocyte apoptotic process (GO:0097284)2.49806481
114natural killer cell differentiation (GO:0001779)2.49412831
115lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48243821
116low-density lipoprotein particle clearance (GO:0034383)2.47727479
117regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.47062276
118positive regulation of alpha-beta T cell proliferation (GO:0046641)2.43448795
119positive regulation of humoral immune response (GO:0002922)2.43189444
120granulocyte activation (GO:0036230)2.42779949
121regulation of natural killer cell differentiation (GO:0032823)2.38711374
122T cell selection (GO:0045058)2.38369231
123response to protozoan (GO:0001562)2.36151844
124response to laminar fluid shear stress (GO:0034616)2.32937555
125positive regulation of interleukin-2 production (GO:0032743)2.32242894
126defense response to protozoan (GO:0042832)2.31833931
127growth hormone receptor signaling pathway (GO:0060396)2.31173854
128myeloid cell activation involved in immune response (GO:0002275)2.30716398
129positive regulation of defense response to virus by host (GO:0002230)2.29865226
130T cell homeostasis (GO:0043029)2.27787392
131positive regulation of histone deacetylation (GO:0031065)2.27229207
132positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.27176194
133positive regulation of macrophage differentiation (GO:0045651)2.26952000
134T cell proliferation (GO:0042098)2.26875420
135JAK-STAT cascade (GO:0007259)2.26814089
136positive T cell selection (GO:0043368)2.26732382
137negative regulation of lipid storage (GO:0010888)2.26176608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.61646081
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.22596370
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.88997207
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.83392073
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.81542197
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.10302828
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.95111330
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.89174920
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.86108514
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.85420091
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80566344
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.79489311
13* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71675499
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.61712913
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44490328
16TP63_17297297_ChIP-ChIP_HaCaT_Human2.38816196
17* MYC_22102868_ChIP-Seq_BL_Human2.31650479
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29657836
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.29295625
20* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23985031
21VDR_21846776_ChIP-Seq_THP-1_Human2.21331835
22* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21102628
23VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.15669767
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14296725
25RUNX_20019798_ChIP-Seq_JUKART_Human2.07936101
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07878916
27* MAF_26560356_Chip-Seq_TH1_Human2.07333266
28MYB_26560356_Chip-Seq_TH2_Human2.00999917
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97466895
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97448796
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.96076760
32SCL_19346495_ChIP-Seq_HPC-7_Human1.95760304
33VDR_24763502_ChIP-Seq_THP-1_Human1.90441510
34LXR_22292898_ChIP-Seq_THP-1_Human1.89459884
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89138372
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87037789
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86338386
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.84959952
39* MYB_26560356_Chip-Seq_TH1_Human1.79518693
40* SPI1_23547873_ChIP-Seq_NB4_Human1.77519853
41RXR_22158963_ChIP-Seq_LIVER_Mouse1.75148109
42TCF7_22412390_ChIP-Seq_EML_Mouse1.73030500
43E2F7_22180533_ChIP-Seq_HELA_Human1.72713043
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.70977482
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.70093679
46* UTX_26944678_Chip-Seq_JUKART_Human1.66511327
47GATA1_22025678_ChIP-Seq_K562_Human1.66202556
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55575129
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54777543
50CLOCK_20551151_ChIP-Seq_293T_Human1.52321898
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51181808
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.47929458
53SPI1_23127762_ChIP-Seq_K562_Human1.46037821
54LXR_22158963_ChIP-Seq_LIVER_Mouse1.45360812
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38825712
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37249236
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.33616647
58RACK7_27058665_Chip-Seq_MCF-7_Human1.32380222
59PU_27001747_Chip-Seq_BMDM_Mouse1.31771144
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30846546
61* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29039053
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.28555897
63* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28094218
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26935013
65PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26192195
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.25669021
67* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24669056
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21549399
69VDR_24787735_ChIP-Seq_THP-1_Human1.20997009
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20823211
71* GATA3_27048872_Chip-Seq_THYMUS_Human1.20548939
72MAF_26560356_Chip-Seq_TH2_Human1.20357318
73* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19977643
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.19737538
75* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19466486
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19299383
77* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19279019
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18237731
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18180586
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17732008
81* KDM2B_26808549_Chip-Seq_DND41_Human1.16776855
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15830175
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13381824
84KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.11644209
85* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11103810
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11081231
87BCOR_27268052_Chip-Seq_Bcells_Human1.09922613
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09330112
89BCL6_27268052_Chip-Seq_Bcells_Human1.08297359
90GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07818218
91* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07374382
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06980500
93* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03488172
94SA1_27219007_Chip-Seq_ERYTHROID_Human1.02223726
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02108655
96* GATA3_26560356_Chip-Seq_TH2_Human1.00384702
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00324297
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99849462
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.99207798
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98348306
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98020853
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97989258
103SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97558798
104KDM2B_26808549_Chip-Seq_K562_Human0.97224538
105* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97119099
106* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96516934
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95626676
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.95342313
109GATA1_19941826_ChIP-Seq_K562_Human0.95269122
110TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94780013
111SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94081981
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94081981
113* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92125067
114FOXO3_23340844_ChIP-Seq_DLD1_Human0.92048248
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.91942200
116GATA2_19941826_ChIP-Seq_K562_Human0.91926821
117* NCOR1_26117541_ChIP-Seq_K562_Human0.90995893
118* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90394298
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90282380
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89785069
121ESR1_21235772_ChIP-Seq_MCF-7_Human0.89347622
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89292715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001835_abnormal_antigen_presentation3.46281456
2MP0003436_decreased_susceptibility_to2.98993538
3MP0000685_abnormal_immune_system2.71000718
4MP0009785_altered_susceptibility_to2.57814013
5MP0005387_immune_system_phenotype2.49629156
6MP0001790_abnormal_immune_system2.49629156
7MP0003300_gastrointestinal_ulcer2.38382397
8* MP0001800_abnormal_humoral_immune2.37864354
9* MP0005000_abnormal_immune_tolerance2.36567759
10MP0005671_abnormal_response_to2.31561387
11MP0002419_abnormal_innate_immunity2.29710887
12* MP0005025_abnormal_response_to2.23374019
13MP0003724_increased_susceptibility_to2.23190090
14* MP0002452_abnormal_antigen_presenting2.22798824
15MP0003303_peritoneal_inflammation2.14011715
16* MP0002723_abnormal_immune_serum2.06717397
17MP0002148_abnormal_hypersensitivity_rea2.05131574
18MP0002166_altered_tumor_susceptibility2.00621831
19MP0005464_abnormal_platelet_physiology1.98973799
20* MP0002420_abnormal_adaptive_immunity1.97612314
21* MP0001819_abnormal_immune_cell1.96793480
22MP0003763_abnormal_thymus_physiology1.94490526
23MP0003191_abnormal_cellular_cholesterol1.94249144
24MP0005058_abnormal_lysosome_morphology1.90027558
25MP0002396_abnormal_hematopoietic_system1.86432297
26MP0005451_abnormal_body_composition1.85647037
27* MP0002405_respiratory_system_inflammati1.84029169
28* MP0004947_skin_inflammation1.83897718
29MP0008260_abnormal_autophagy1.82979215
30MP0006082_CNS_inflammation1.82774015
31MP0010155_abnormal_intestine_physiology1.81434742
32MP0001845_abnormal_inflammatory_respons1.65990849
33* MP0002398_abnormal_bone_marrow1.65735451
34MP0001853_heart_inflammation1.65495528
35MP0004510_myositis1.62443542
36* MP0000716_abnormal_immune_system1.62342418
37MP0001873_stomach_inflammation1.62229272
38MP0009840_abnormal_foam_cell1.61870986
39MP0001533_abnormal_skeleton_physiology1.61410818
40MP0003172_abnormal_lysosome_physiology1.61220095
41MP0009333_abnormal_splenocyte_physiolog1.59344873
42MP0002006_tumorigenesis1.55770044
43MP0002138_abnormal_hepatobiliary_system1.53738473
44MP0000689_abnormal_spleen_morphology1.52777201
45MP0003566_abnormal_cell_adhesion1.51832304
46MP0003183_abnormal_peptide_metabolism1.50778317
47MP0004381_abnormal_hair_follicle1.49039179
48MP0000569_abnormal_digit_pigmentation1.46583762
49MP0009278_abnormal_bone_marrow1.45528664
50MP0000858_altered_metastatic_potential1.44256163
51MP0002722_abnormal_immune_system1.44154434
52MP0010352_gastrointestinal_tract_polyps1.42954819
53MP0008469_abnormal_protein_level1.40268680
54MP0004808_abnormal_hematopoietic_stem1.40100148
55MP0005397_hematopoietic_system_phenotyp1.38319870
56MP0001545_abnormal_hematopoietic_system1.38319870
57MP0009764_decreased_sensitivity_to1.37540006
58* MP0002429_abnormal_blood_cell1.36650162
59MP0002254_reproductive_system_inflammat1.35476599
60MP0005360_urolithiasis1.30929016
61MP0003448_altered_tumor_morphology1.29915260
62MP0003705_abnormal_hypodermis_morpholog1.29652597
63MP0002933_joint_inflammation1.23377643
64MP0000465_gastrointestinal_hemorrhage1.23185868
65MP0005023_abnormal_wound_healing1.19844402
66MP0000343_altered_response_to1.19601446
67MP0008438_abnormal_cutaneous_collagen1.19588105
68MP0004883_abnormal_blood_vessel1.15935939
69MP0005164_abnormal_response_to1.07137035
70MP0002139_abnormal_hepatobiliary_system1.05370165
71MP0000609_abnormal_liver_physiology1.04925999
72MP0000703_abnormal_thymus_morphology1.04004392
73MP0000604_amyloidosis1.03325116
74MP0003866_abnormal_defecation1.01154287
75MP0003091_abnormal_cell_migration1.00321646
76MP0009763_increased_sensitivity_to1.00192419
77MP0003453_abnormal_keratinocyte_physiol1.00020154
78MP0003828_pulmonary_edema0.99806788
79MP0003279_aneurysm0.99696734
80MP0002998_abnormal_bone_remodeling0.99688733
81MP0003075_altered_response_to0.97800370
82MP0005310_abnormal_salivary_gland0.97632485
83MP0003045_fibrosis0.96373553
84MP0000490_abnormal_crypts_of0.94390337
85MP0008004_abnormal_stomach_pH0.92890071
86MP0005174_abnormal_tail_pigmentation0.91308380
87MP0005166_decreased_susceptibility_to0.90708873
88MP0001958_emphysema0.90025754
89MP0010307_abnormal_tumor_latency0.87482996
90MP0002136_abnormal_kidney_physiology0.87233249
91MP0001849_ear_inflammation0.86931586
92MP0001663_abnormal_digestive_system0.86506907
93MP0000249_abnormal_blood_vessel0.85960917
94MP0005076_abnormal_cell_differentiation0.85760349
95MP0001243_abnormal_dermal_layer0.82398124
96MP0005365_abnormal_bile_salt0.80458058
97MP0002877_abnormal_melanocyte_morpholog0.79972105
98MP0004130_abnormal_muscle_cell0.79778574
99MP0010329_abnormal_lipoprotein_level0.79360370
100MP0001851_eye_inflammation0.78937040
101MP0005390_skeleton_phenotype0.78566604
102MP0003252_abnormal_bile_duct0.78465968
103MP0003656_abnormal_erythrocyte_physiolo0.78211428
104MP0002060_abnormal_skin_morphology0.78079594
105MP0005319_abnormal_enzyme/_coenzyme0.77075662
106MP0005075_abnormal_melanosome_morpholog0.76768618
107MP0005670_abnormal_white_adipose0.76656642
108MP0000015_abnormal_ear_pigmentation0.76432124
109MP0004782_abnormal_surfactant_physiolog0.76289660
110MP0003795_abnormal_bone_structure0.75841596
111MP0000598_abnormal_liver_morphology0.74905561
112MP0000371_diluted_coat_color0.73848378
113MP0003690_abnormal_glial_cell0.73132362
114MP0009643_abnormal_urine_homeostasis0.72386093
115MP0005409_darkened_coat_color0.69254754
116MP0000767_abnormal_smooth_muscle0.62641403
117MP0004264_abnormal_extraembryonic_tissu0.61492425
118MP0001348_abnormal_lacrimal_gland0.61164737
119MP0009115_abnormal_fat_cell0.60042178
120MP0009765_abnormal_xenobiotic_induced0.59092309

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.78486959
2Recurrent abscess formation (HP:0002722)4.26828303
3Recurrent bacterial skin infections (HP:0005406)3.95839335
4Recurrent gram-negative bacterial infections (HP:0005420)3.52999764
5Elevated erythrocyte sedimentation rate (HP:0003565)3.43123277
6Autoimmune thrombocytopenia (HP:0001973)3.39907372
7Recurrent fungal infections (HP:0002841)3.37963026
8Myositis (HP:0100614)3.30841056
9Systemic lupus erythematosus (HP:0002725)3.26533127
10Recurrent viral infections (HP:0004429)3.26439508
11Chronic otitis media (HP:0000389)3.04966255
12Periodontitis (HP:0000704)3.02144338
13Spontaneous hematomas (HP:0007420)2.95286413
14Pustule (HP:0200039)2.92796051
15Encephalitis (HP:0002383)2.91937014
16Myocardial infarction (HP:0001658)2.87658273
17Keratoconjunctivitis sicca (HP:0001097)2.84158594
18Interstitial pulmonary disease (HP:0006530)2.83322727
19Mediastinal lymphadenopathy (HP:0100721)2.83041045
20Recurrent skin infections (HP:0001581)2.81760937
21Cellulitis (HP:0100658)2.78825788
22Vacuolated lymphocytes (HP:0001922)2.78550052
23Abnormality of the nasal mucosa (HP:0000433)2.77438253
24Orchitis (HP:0100796)2.71161307
25Abnormality of macrophages (HP:0004311)2.70584856
26Nasal polyposis (HP:0100582)2.66572016
27Vasculitis (HP:0002633)2.65132776
28Recurrent bronchitis (HP:0002837)2.64678060
29Hematochezia (HP:0002573)2.64442578
30Thrombocytosis (HP:0001894)2.63859303
31IgM deficiency (HP:0002850)2.59336815
32Colitis (HP:0002583)2.58495577
33Arterial thrombosis (HP:0004420)2.58370728
34Osteolytic defects of the hand bones (HP:0009699)2.58010869
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.58010869
36Abnormality of T cell number (HP:0011839)2.56390531
37Keratoconjunctivitis (HP:0001096)2.55486817
38Gastrointestinal infarctions (HP:0005244)2.54665174
39Inflammation of the large intestine (HP:0002037)2.50491825
40Meningitis (HP:0001287)2.50308401
41T lymphocytopenia (HP:0005403)2.49138383
42Abnormal platelet volume (HP:0011876)2.46889282
43Complement deficiency (HP:0004431)2.46643435
44Abnormal delayed hypersensitivity skin test (HP:0002963)2.46430811
45Glomerulonephritis (HP:0000099)2.46271909
46Epistaxis (HP:0000421)2.46089148
47Stomatitis (HP:0010280)2.45249886
48Gingival bleeding (HP:0000225)2.44853051
49Gastrointestinal inflammation (HP:0004386)2.44630083
50Recurrent cutaneous fungal infections (HP:0011370)2.40774979
51Chronic mucocutaneous candidiasis (HP:0002728)2.40774979
52Gingivitis (HP:0000230)2.37524384
53Abnormality of complement system (HP:0005339)2.36128465
54Malnutrition (HP:0004395)2.34046437
55Amyloidosis (HP:0011034)2.31751692
56Abnormality of the prostate (HP:0008775)2.31092576
57Increased mean platelet volume (HP:0011877)2.31081238
58Panhypogammaglobulinemia (HP:0003139)2.29205415
59Abnormality of T cells (HP:0002843)2.28113180
60Dysostosis multiplex (HP:0000943)2.27404971
61Optic neuritis (HP:0100653)2.23095417
62Retrobulbar optic neuritis (HP:0100654)2.23095417
63Agammaglobulinemia (HP:0004432)2.21741533
64Restrictive lung disease (HP:0002091)2.21089082
65Osteomyelitis (HP:0002754)2.20961284
66Leukocytosis (HP:0001974)2.20740368
67Hypergammaglobulinemia (HP:0010702)2.20346004
68Urinary glycosaminoglycan excretion (HP:0003541)2.18521627
69Mucopolysacchariduria (HP:0008155)2.18521627
70Hypochromic anemia (HP:0001931)2.18518094
71Increased cerebral lipofuscin (HP:0011813)2.17717386
72Aortic aneurysm (HP:0004942)2.17151622
73Pulmonary infiltrates (HP:0002113)2.16246049
74Abnormality of liposaccharide metabolism (HP:0010968)2.15433908
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.15433908
76Abnormality of glycolipid metabolism (HP:0010969)2.15433908
77Abnormality of the peritoneum (HP:0002585)2.13968441
78Obstructive lung disease (HP:0006536)2.13517520
79Chronic obstructive pulmonary disease (HP:0006510)2.13517520
80Abnormal platelet function (HP:0011869)2.13106741
81Impaired platelet aggregation (HP:0003540)2.13106741
82Purpura (HP:0000979)2.12971970
83Peritonitis (HP:0002586)2.12889281
84Joint hemorrhage (HP:0005261)2.11144658
85Nephritis (HP:0000123)2.10838256
86Prolonged bleeding time (HP:0003010)2.10195019
87Prostate neoplasm (HP:0100787)2.09792876
88Eosinophilia (HP:0001880)2.09073606
89Petechiae (HP:0000967)2.08273388
90IgA deficiency (HP:0002720)2.08088380
91Abnormality of T cell physiology (HP:0011840)2.07883192
92Premature loss of primary teeth (HP:0006323)2.07663723
93Abnormality of the pleura (HP:0002103)2.07061775
94Spondylolisthesis (HP:0003302)2.06996784
95Abnormality of polysaccharide metabolism (HP:0011012)2.06932073
96Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06932073
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06932073
98Viral hepatitis (HP:0006562)2.06445762
99Hemoptysis (HP:0002105)2.05587853
100Emphysema (HP:0002097)2.05432905
101Increased IgM level (HP:0003496)2.04394760
102Sepsis (HP:0100806)2.03934409
103Gastrointestinal stroma tumor (HP:0100723)2.03721202
104Esophageal varix (HP:0002040)2.02746942
105Lymphopenia (HP:0001888)2.02173692
106Loss of speech (HP:0002371)2.01770844
107Increased IgE level (HP:0003212)2.01458744
108Verrucae (HP:0200043)2.01395352
109Papilloma (HP:0012740)2.01395352
110Abnormality of cells of the lymphoid lineage (HP:0012140)1.99851266
111Skin ulcer (HP:0200042)1.99476729
112Granulocytopenia (HP:0001913)1.96867384
113Chronic diarrhea (HP:0002028)1.95982198
114Episodic fever (HP:0001954)1.95611958
115Absent frontal sinuses (HP:0002688)1.95246300
116Pulmonary embolism (HP:0002204)1.94978182
117Polygenic inheritance (HP:0010982)1.94250619
118Persistence of primary teeth (HP:0006335)1.94058789
119Urticaria (HP:0001025)1.92778129
120Hemorrhage of the eye (HP:0011885)1.92512811
121Anorexia (HP:0002039)1.92283010
122Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91954547
123Spinal cord lesions (HP:0100561)1.91784309
124Syringomyelia (HP:0003396)1.91784309
125Gangrene (HP:0100758)1.91573381
126Cerebral aneurysm (HP:0004944)1.91151491
127Chest pain (HP:0100749)1.90575705
128Joint swelling (HP:0001386)1.90559139
129Segmental peripheral demyelination/remyelination (HP:0003481)1.89750940
130Recurrent sinusitis (HP:0011108)1.88793081
131Abnormality of the fingertips (HP:0001211)1.86219519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.65331349
2PRPF4B3.05829223
3JAK32.91096423
4TYK22.68156980
5MAP3K142.53032534
6ERN12.46575507
7TGFBR22.34985439
8TRIB32.33697786
9TBK12.25769215
10BLK2.22935312
11STK102.22126710
12ZAP702.09910556
13MAP2K32.05280600
14PKN22.01805438
15TXK1.89042436
16KIT1.87766644
17FGFR41.83453702
18IRAK31.82736446
19IKBKE1.79971152
20TAOK31.78870388
21IKBKB1.73814039
22JAK11.72099717
23TTN1.71662408
24TNK21.71379476
25ITK1.70074514
26TEC1.67429975
27IRAK41.64105164
28SIK11.62098985
29EEF2K1.61766642
30BTK1.59155450
31LRRK21.55577235
32MAP3K101.54028854
33SMG11.47319273
34CHUK1.39306112
35EPHB11.39243314
36CSK1.38683604
37RPS6KA41.33868171
38SYK1.33816782
39CSF1R1.33612149
40MAP3K31.32845890
41CDC42BPA1.32519822
42NEK91.32278938
43NME21.28490094
44FGFR31.25129731
45RIPK41.24026551
46FLT31.22559515
47MAP3K11.16973657
48MARK21.16580248
49PTK61.16008791
50GRK61.15927924
51PRKD21.14486681
52KDR1.13471396
53HCK1.11862277
54LCK1.09571066
55JAK21.06005483
56PIM11.04846728
57CAMK1D1.02559653
58MST1R0.99989887
59RIPK10.99545389
60CLK10.94608518
61TRPM70.93663709
62MAP3K130.90827975
63EPHA30.89930270
64MST40.89077240
65TAOK20.86254824
66MAP3K60.85955072
67HIPK20.85729568
68KSR20.85027180
69NLK0.84839253
70PIM20.84712102
71MAPK70.82350095
72PDPK10.82304067
73MAP3K110.81647173
74CDK90.80104889
75LYN0.76653852
76MARK30.75213805
77TGFBR10.74158426
78MAPK120.73660076
79TAOK10.70729066
80BMPR20.70179699
81CDK60.69850340
82IRAK10.69630067
83YES10.65738664
84STK40.60637669
85MATK0.59604709
86CDK40.58438696
87FGR0.58223610
88TESK20.58003514
89MAP3K70.57213989
90ICK0.55188311
91IRAK20.54359457
92MAP3K80.53610187
93FYN0.53381511
94MAPKAPK30.53380460
95PAK40.50818956
96BMX0.50569831
97MAPK110.50234206
98EGFR0.49708955
99SIK20.49632489
100MAP3K20.49507181
101MAPKAPK20.48741104
102PIK3CA0.48376432
103PDGFRB0.48371224
104STK30.47922188
105RET0.46681964
106RPS6KA20.46506717
107ABL10.46295712
108RPS6KA60.46113226
109STK380.45461308
110MAP2K60.44090932
111FES0.43081716
112PIK3CG0.42933894
113PTK2B0.42425580
114SGK30.41305474
115MAP2K20.40793497
116DYRK1B0.40283182
117RPS6KB20.38780190
118CDK120.38004655
119PRKCQ0.37899966
120PDK10.37191620
121RPS6KL10.37032407
122RPS6KC10.37032407
123PRKG20.36774742
124MYLK0.36076827
125CAMK1G0.35626515
126SIK30.35595916
127PRKCD0.34988098
128IGF1R0.34389508
129TIE10.34220228

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.95124275
2Leishmaniasis_Homo sapiens_hsa051402.69306948
3Primary immunodeficiency_Homo sapiens_hsa053402.52073961
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.42704063
5Osteoclast differentiation_Homo sapiens_hsa043802.20063161
6Measles_Homo sapiens_hsa051622.07494082
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.95508083
8B cell receptor signaling pathway_Homo sapiens_hsa046621.91258508
9Antigen processing and presentation_Homo sapiens_hsa046121.88637366
10Legionellosis_Homo sapiens_hsa051341.85744098
11* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.85104618
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83962182
13Pertussis_Homo sapiens_hsa051331.80856768
14Type I diabetes mellitus_Homo sapiens_hsa049401.78948297
15Hematopoietic cell lineage_Homo sapiens_hsa046401.74233081
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.72225875
17Caffeine metabolism_Homo sapiens_hsa002321.69043958
18Toxoplasmosis_Homo sapiens_hsa051451.66576488
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65208581
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.60478686
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57215016
22Complement and coagulation cascades_Homo sapiens_hsa046101.55438557
23Malaria_Homo sapiens_hsa051441.52415037
24Allograft rejection_Homo sapiens_hsa053301.51053814
25Influenza A_Homo sapiens_hsa051641.50171459
26* Jak-STAT signaling pathway_Homo sapiens_hsa046301.47622692
27Graft-versus-host disease_Homo sapiens_hsa053321.45885893
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.44312221
29Tuberculosis_Homo sapiens_hsa051521.39079843
30TNF signaling pathway_Homo sapiens_hsa046681.38381623
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.36145922
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.32821144
33T cell receptor signaling pathway_Homo sapiens_hsa046601.32176747
34Apoptosis_Homo sapiens_hsa042101.31524568
35Herpes simplex infection_Homo sapiens_hsa051681.31405726
36Other glycan degradation_Homo sapiens_hsa005111.29698861
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25874337
38Lysosome_Homo sapiens_hsa041421.22631119
39Viral myocarditis_Homo sapiens_hsa054161.20400760
40Acute myeloid leukemia_Homo sapiens_hsa052211.18412987
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15903167
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15623042
43Shigellosis_Homo sapiens_hsa051311.13927225
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.13908447
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12065571
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.11511904
47Chronic myeloid leukemia_Homo sapiens_hsa052201.09946334
48* Hepatitis B_Homo sapiens_hsa051611.04697258
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03430396
50Salmonella infection_Homo sapiens_hsa051321.02412767
51Chemokine signaling pathway_Homo sapiens_hsa040621.01252947
52Hepatitis C_Homo sapiens_hsa051601.00328682
53Small cell lung cancer_Homo sapiens_hsa052220.99734237
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98444871
55VEGF signaling pathway_Homo sapiens_hsa043700.97630601
56Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93117477
57Platelet activation_Homo sapiens_hsa046110.92826686
58Pancreatic cancer_Homo sapiens_hsa052120.87668707
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.85036494
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84355625
61PPAR signaling pathway_Homo sapiens_hsa033200.82119705
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82101335
63ABC transporters_Homo sapiens_hsa020100.80905600
64Renal cell carcinoma_Homo sapiens_hsa052110.80252869
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.79697245
66Insulin resistance_Homo sapiens_hsa049310.78043646
67Fatty acid degradation_Homo sapiens_hsa000710.75233202
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.74133083
69Amoebiasis_Homo sapiens_hsa051460.72449213
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70918944
71Prolactin signaling pathway_Homo sapiens_hsa049170.69865521
72Endocytosis_Homo sapiens_hsa041440.68952529
73Starch and sucrose metabolism_Homo sapiens_hsa005000.67907778
74Autoimmune thyroid disease_Homo sapiens_hsa053200.67305387
75GnRH signaling pathway_Homo sapiens_hsa049120.66511856
76Asthma_Homo sapiens_hsa053100.65670968
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65216752
78Choline metabolism in cancer_Homo sapiens_hsa052310.63381759
79Rheumatoid arthritis_Homo sapiens_hsa053230.63196317
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.61615886
81Pentose phosphate pathway_Homo sapiens_hsa000300.59121515
82Tryptophan metabolism_Homo sapiens_hsa003800.58345074
83Phagosome_Homo sapiens_hsa041450.57795780
84HTLV-I infection_Homo sapiens_hsa051660.56695407
85mTOR signaling pathway_Homo sapiens_hsa041500.56305773
86Endometrial cancer_Homo sapiens_hsa052130.55558975
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55425889
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55399420
89Dorso-ventral axis formation_Homo sapiens_hsa043200.55306792
90FoxO signaling pathway_Homo sapiens_hsa040680.54857671
91Viral carcinogenesis_Homo sapiens_hsa052030.54129775
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53670626
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52779641
94Inositol phosphate metabolism_Homo sapiens_hsa005620.52619985
95African trypanosomiasis_Homo sapiens_hsa051430.52078154
96HIF-1 signaling pathway_Homo sapiens_hsa040660.50629886
97Epstein-Barr virus infection_Homo sapiens_hsa051690.49442345
98Proteoglycans in cancer_Homo sapiens_hsa052050.47619690
99Lysine degradation_Homo sapiens_hsa003100.47352527
100Histidine metabolism_Homo sapiens_hsa003400.47123655
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.47072669
102Bladder cancer_Homo sapiens_hsa052190.46330527
103Focal adhesion_Homo sapiens_hsa045100.46044527
104Arginine biosynthesis_Homo sapiens_hsa002200.45958616
105p53 signaling pathway_Homo sapiens_hsa041150.44882523
106Adherens junction_Homo sapiens_hsa045200.44122715
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.43346531
108Non-small cell lung cancer_Homo sapiens_hsa052230.42482674
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41743439
110Colorectal cancer_Homo sapiens_hsa052100.40272937
111Thyroid cancer_Homo sapiens_hsa052160.39011860
112MAPK signaling pathway_Homo sapiens_hsa040100.38827410
113Galactose metabolism_Homo sapiens_hsa000520.38215054
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.36572167
115Renin-angiotensin system_Homo sapiens_hsa046140.36436371
116ErbB signaling pathway_Homo sapiens_hsa040120.35322183
117Insulin signaling pathway_Homo sapiens_hsa049100.34321186
118Notch signaling pathway_Homo sapiens_hsa043300.33773002
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32815422
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32802211
121Retinol metabolism_Homo sapiens_hsa008300.32800274
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.32641343
123Prostate cancer_Homo sapiens_hsa052150.32240414
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.31333112
125Chemical carcinogenesis_Homo sapiens_hsa052040.31082281

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