STATH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epidermal cell differentiation (GO:0009913)8.52456941
2O-glycan processing (GO:0016266)7.78995727
3retina homeostasis (GO:0001895)7.63626272
4negative regulation of homotypic cell-cell adhesion (GO:0034111)7.36107647
5apical protein localization (GO:0045176)7.03033019
6long-chain fatty acid biosynthetic process (GO:0042759)6.71644207
7establishment of skin barrier (GO:0061436)6.32387121
8lipoxygenase pathway (GO:0019372)6.27506496
9positive regulation of endothelial cell differentiation (GO:0045603)6.06352461
10hair cell differentiation (GO:0035315)5.65085170
11membrane raft organization (GO:0031579)5.59202026
12linoleic acid metabolic process (GO:0043651)5.46803292
13regulation of water loss via skin (GO:0033561)5.42530813
14regulation of platelet aggregation (GO:0090330)5.38586898
15protein O-linked glycosylation (GO:0006493)5.19763460
16positive regulation of p38MAPK cascade (GO:1900745)5.07238991
17multicellular organismal water homeostasis (GO:0050891)5.01049641
18negative regulation of interleukin-17 production (GO:0032700)4.99700493
19epidermis development (GO:0008544)4.98721125
20localization within membrane (GO:0051668)4.96703835
21negative regulation of cell-cell adhesion (GO:0022408)4.82935481
22asymmetric protein localization (GO:0008105)4.69322723
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)4.66913039
24antimicrobial humoral response (GO:0019730)4.60771212
25regulation of endothelial cell differentiation (GO:0045601)4.51281940
26negative regulation of platelet activation (GO:0010544)4.50145948
27superoxide anion generation (GO:0042554)4.40792351
28water homeostasis (GO:0030104)4.34473341
29negative regulation of cytokine-mediated signaling pathway (GO:0001960)4.27388682
30negative regulation of response to cytokine stimulus (GO:0060761)4.16460968
31regulation of mitochondrial depolarization (GO:0051900)4.09730238
32regulation of integrin-mediated signaling pathway (GO:2001044)3.86507281
33regulation of p38MAPK cascade (GO:1900744)3.84413927
34regulation of protein polyubiquitination (GO:1902914)3.80611127
35positive regulation of chemokine biosynthetic process (GO:0045080)3.78673227
36positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.78034323
37regulation of cholesterol homeostasis (GO:2000188)3.70419412
38positive regulation of vasodilation (GO:0045909)3.68024580
39defense response to fungus (GO:0050832)3.60625495
40* negative regulation of bone mineralization (GO:0030502)3.56842200
41positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.49284726
42negative regulation of muscle cell apoptotic process (GO:0010656)3.44239545
43transepithelial transport (GO:0070633)3.42336259
44glomerular filtration (GO:0003094)3.31313948
45intestinal epithelial cell development (GO:0060576)3.27953841
46regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.22937103
47regulation of interleukin-17 production (GO:0032660)3.14992591
48* negative regulation of biomineral tissue development (GO:0070168)3.14510599
49regulation of interferon-beta biosynthetic process (GO:0045357)3.13739671
50embryonic process involved in female pregnancy (GO:0060136)3.11933394
51desmosome organization (GO:0002934)3.11457035
52regulation of homotypic cell-cell adhesion (GO:0034110)3.10919033
53regulation of membrane protein ectodomain proteolysis (GO:0051043)3.09110035
54regulation of bile acid biosynthetic process (GO:0070857)3.07229026
55negative regulation of cell-substrate adhesion (GO:0010812)3.04089031
56wound healing (GO:0042060)3.01298292
57renal filtration (GO:0097205)2.98966256
58one-carbon compound transport (GO:0019755)2.96123561
59regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.94800249
60endothelial cell chemotaxis (GO:0035767)2.92452642
61regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.92102691
62regulation of chemokine biosynthetic process (GO:0045073)2.88727341
63eyelid development in camera-type eye (GO:0061029)2.87216182
64negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.84974002
65negative regulation of interferon-gamma production (GO:0032689)2.83668706
66regulation of type 2 immune response (GO:0002828)2.81265487
67ectoderm development (GO:0007398)2.80722102
68positive regulation of chemokine secretion (GO:0090197)2.77894797
69regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.75553417
70response to vitamin A (GO:0033189)2.73492543
71epithelial cell differentiation (GO:0030855)2.73296757
72planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68288417
73positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.66643325
74regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.66643325
75Rho protein signal transduction (GO:0007266)2.63779253
76metanephric mesenchyme development (GO:0072075)2.63264242
77regulation of T cell migration (GO:2000404)2.59735819
78negative regulation of smooth muscle cell migration (GO:0014912)2.57748588
79enteric nervous system development (GO:0048484)2.56976408
80negative regulation of vascular permeability (GO:0043116)2.56341775
81interkinetic nuclear migration (GO:0022027)2.52862789
82regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.52218443
83epithelium development (GO:0060429)2.51893331
84antibacterial humoral response (GO:0019731)2.48866590
85lymph node development (GO:0048535)2.47224587
86hypotonic response (GO:0006971)2.45613241
87negative regulation of smooth muscle cell proliferation (GO:0048662)2.44600457
88regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.43971640
89positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.43971640
90regulation of platelet activation (GO:0010543)2.43683430
91defense response to Gram-negative bacterium (GO:0050829)2.42467490
92tissue homeostasis (GO:0001894)2.41901360
93response to leptin (GO:0044321)2.41150187
94fibroblast migration (GO:0010761)2.41098072
95regulation of vasodilation (GO:0042312)2.40140463
96response to fungus (GO:0009620)2.39535825
97hippo signaling (GO:0035329)2.31987934
98keratinization (GO:0031424)17.0180049
99peptide cross-linking (GO:0018149)12.1384178
100keratinocyte differentiation (GO:0030216)10.0306992

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.63207631
2ESR1_21235772_ChIP-Seq_MCF-7_Human3.35057692
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.14557226
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.93809751
5ZNF217_24962896_ChIP-Seq_MCF-7_Human2.75043006
6ESR2_21235772_ChIP-Seq_MCF-7_Human2.55154133
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.33015892
8TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.15541872
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.07200312
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.07070034
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.01775576
12SOX9_24532713_ChIP-Seq_HFSC_Mouse2.01508005
13GATA2_21666600_ChIP-Seq_HMVEC_Human1.92760207
14NFIB_24661679_ChIP-Seq_LUNG_Mouse1.91907846
15SOX2_20726797_ChIP-Seq_SW620_Human1.90214845
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.86245455
17PPAR_26484153_Chip-Seq_NCI-H1993_Human1.85976365
18FOXM1_26456572_ChIP-Seq_MCF-7_Human1.82490656
19ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.82284970
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80566238
21AHR_22903824_ChIP-Seq_MCF-7_Human1.78324378
22CJUN_26792858_Chip-Seq_BT549_Human1.74365936
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66037746
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.65283646
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63766565
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63119893
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.60900301
28GATA3_24758297_ChIP-Seq_MCF-7_Human1.60441863
29RUNX1_27514584_Chip-Seq_MCF-7_Human1.60212734
30VDR_22108803_ChIP-Seq_LS180_Human1.57305133
31SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.55046432
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.55046432
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.55037463
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.53787602
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53677245
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.47790760
37RXR_22108803_ChIP-Seq_LS180_Human1.47711895
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46014613
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.43511914
40CDX2_20551321_ChIP-Seq_CACO-2_Human1.43084871
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40885552
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40849344
43KLF5_25053715_ChIP-Seq_YYC3_Human1.39411308
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39324128
45GATA4_25053715_ChIP-Seq_YYC3_Human1.38295069
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36995915
47FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.36985117
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.36257267
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34002668
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.30798056
51HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30212014
52RUNX_20019798_ChIP-Seq_JUKART_Human1.29503726
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.27562809
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.27478392
55CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27374966
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24692963
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.23753781
58TBX20_22080862_ChIP-Seq_HEART_Mouse1.22677663
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.22677663
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.21209720
61GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.20015800
62SMAD3_21741376_ChIP-Seq_HESCs_Human1.18462958
63SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15537519
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.15283613
65* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13168480
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12476295
67GATA6_21074721_ChIP-Seq_CACO-2_Human1.12386376
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11428407
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10236202
70NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10236202
71TP63_23658742_ChIP-Seq_EP156T_Human1.06795907
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04120387
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.03763667
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03722501
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.03666349
76JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02574710
77FOXA1_25552417_ChIP-Seq_VCAP_Human1.01211635
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00428768
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98708459
80CLOCK_20551151_ChIP-Seq_293T_Human0.96577339
81TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94553109
82HTT_18923047_ChIP-ChIP_STHdh_Human0.91681163
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.91165951
84BCAT_22108803_ChIP-Seq_LS180_Human0.90877068
85SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90662616
86STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.88703461
87PIAS1_25552417_ChIP-Seq_VCAP_Human0.88145498
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88112618
89FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87708105
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85748534
91KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85748534
92KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85748534
93MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.85571015
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85472807
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85249736
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85176188
97STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.84830888
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.84612566
99THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84134601
100AR_25329375_ChIP-Seq_VCAP_Human0.83166537

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile6.63225009
2MP0002796_impaired_skin_barrier4.66711140
3MP0004043_abnormal_pH_regulation3.93884234
4MP0010352_gastrointestinal_tract_polyps3.62418740
5MP0005503_abnormal_tendon_morphology3.17712960
6MP0005501_abnormal_skin_physiology3.13686341
7MP0005670_abnormal_white_adipose2.99462352
8MP0010678_abnormal_skin_adnexa2.98307070
9MP0003724_increased_susceptibility_to2.28304341
10MP0009780_abnormal_chondrocyte_physiolo2.18288285
11MP0010368_abnormal_lymphatic_system2.17421025
12MP0004185_abnormal_adipocyte_glucose2.12373993
13MP0005666_abnormal_adipose_tissue2.10076149
14MP0010234_abnormal_vibrissa_follicle11.7816955
15MP0000465_gastrointestinal_hemorrhage1.82728597
16MP0001851_eye_inflammation1.73460897
17MP0003705_abnormal_hypodermis_morpholog1.69630226
18MP0000467_abnormal_esophagus_morphology1.62806094
19MP0000678_abnormal_parathyroid_gland1.61604307
20MP0002098_abnormal_vibrissa_morphology1.57329720
21MP0005375_adipose_tissue_phenotype1.51528938
22MP0003453_abnormal_keratinocyte_physiol1.51359507
23MP0010771_integument_phenotype1.45357571
24MP0002166_altered_tumor_susceptibility1.43336453
25MP0005409_darkened_coat_color1.41222103
26MP0002249_abnormal_larynx_morphology1.39282563
27MP0003828_pulmonary_edema1.35772646
28MP0001216_abnormal_epidermal_layer1.28757181
29MP0002108_abnormal_muscle_morphology1.28355311
30MP0001879_abnormal_lymphatic_vessel1.21605415
31MP0009333_abnormal_splenocyte_physiolog1.20856644
32MP0004130_abnormal_muscle_cell1.20442730
33MP0005023_abnormal_wound_healing1.12989983
34MP0009115_abnormal_fat_cell1.11683688
35MP0000762_abnormal_tongue_morphology1.10046833
36MP0001502_abnormal_circadian_rhythm1.08049021
37MP0002060_abnormal_skin_morphology1.05806738
38MP0002933_joint_inflammation1.04075620
39MP0000681_abnormal_thyroid_gland1.00546452
40MP0006138_congestive_heart_failure0.97095779
41MP0000377_abnormal_hair_follicle0.95782963
42MP0004947_skin_inflammation0.95287588
43MP0002009_preneoplasia0.93013098
44MP0004264_abnormal_extraembryonic_tissu0.92259364
45MP0000613_abnormal_salivary_gland0.88594755
46MP0005166_decreased_susceptibility_to0.88310108
47MP0008004_abnormal_stomach_pH0.87130184
48MP0001853_heart_inflammation0.86126109
49MP0001784_abnormal_fluid_regulation0.86036570
50MP0002006_tumorigenesis0.81614604
51MP0000470_abnormal_stomach_morphology0.74955176
52MP0000003_abnormal_adipose_tissue0.74944177
53MP0000049_abnormal_middle_ear0.72862716
54MP0001765_abnormal_ion_homeostasis0.70989435
55MP0001533_abnormal_skeleton_physiology0.69179449
56MP0005365_abnormal_bile_salt0.68159632
57MP0002971_abnormal_brown_adipose0.66583026
58MP0003566_abnormal_cell_adhesion0.66308868
59MP0001756_abnormal_urination0.66021079
60MP0000733_abnormal_muscle_development0.64265576
61MP0000920_abnormal_myelination0.63743853
62MP0005164_abnormal_response_to0.63341487
63MP0010030_abnormal_orbit_morphology0.62878197
64MP0001958_emphysema0.60703481
65MP0003938_abnormal_ear_development0.57342060
66MP0004883_abnormal_blood_vessel0.57115001
67MP0009931_abnormal_skin_appearance0.55778176
68MP0005390_skeleton_phenotype0.55702190
69MP0004885_abnormal_endolymph0.54894201
70MP0001270_distended_abdomen0.54565557
71MP0000566_synostosis0.52741014
72MP0002128_abnormal_blood_circulation0.51032082
73MP0001243_abnormal_dermal_layer0.48278206
74MP0003303_peritoneal_inflammation0.46742225
75MP0005508_abnormal_skeleton_morphology0.45975375
76MP0000759_abnormal_skeletal_muscle0.45683487
77MP0002970_abnormal_white_adipose0.45475321
78MP0001544_abnormal_cardiovascular_syste0.44613509
79MP0005385_cardiovascular_system_phenoty0.44613509
80MP0001873_stomach_inflammation0.44568844
81MP0008961_abnormal_basal_metabolism0.44016959
82MP0000371_diluted_coat_color0.43978568
83MP0005448_abnormal_energy_balance0.42582646
84MP0005647_abnormal_sex_gland0.42482957
85MP0009643_abnormal_urine_homeostasis0.41882137
86MP0003950_abnormal_plasma_membrane0.41076821
87MP0002136_abnormal_kidney_physiology0.41073183
88MP0005076_abnormal_cell_differentiation0.40192875
89MP0004087_abnormal_muscle_fiber0.39155984
90MP0010630_abnormal_cardiac_muscle0.38680573
91MP0000367_abnormal_coat/_hair0.38522552
92MP0005310_abnormal_salivary_gland0.38325763
93MP0005636_abnormal_mineral_homeostasis0.37684147
94MP0002332_abnormal_exercise_endurance0.37488660
95MP0010386_abnormal_urinary_bladder0.37048383
96MP0005646_abnormal_pituitary_gland0.36972009
97MP0002138_abnormal_hepatobiliary_system0.36849561
98MP0001542_abnormal_bone_strength0.35689053
99MP0002405_respiratory_system_inflammati0.35637970
100MP0005464_abnormal_platelet_physiology0.34912395

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)9.88290738
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)7.31995324
3Hyperactive renin-angiotensin system (HP:0000841)6.30812929
4Villous atrophy (HP:0011473)6.09467728
5Abnormality of small intestinal villus morphology (HP:0011472)6.09467728
6Lip pit (HP:0100267)5.65010979
7Hyperkalemia (HP:0002153)5.36806646
8Parakeratosis (HP:0001036)5.18063264
9Congenital ichthyosiform erythroderma (HP:0007431)5.06670216
10Oral leukoplakia (HP:0002745)5.02154451
11Erythroderma (HP:0001019)4.95105406
12Nasal polyposis (HP:0100582)4.87937587
13Sparse scalp hair (HP:0002209)4.48033387
14Decreased circulating renin level (HP:0003351)4.44192694
15Abnormality of the nasal mucosa (HP:0000433)4.37781963
16Acanthosis nigricans (HP:0000956)4.26215877
17Chronic bronchitis (HP:0004469)4.16291554
18Neonatal hypoglycemia (HP:0001998)4.01318325
19Brittle hair (HP:0002299)3.89940602
20Eczematoid dermatitis (HP:0000976)3.82567021
21Hypokalemic alkalosis (HP:0001949)3.44669068
22Oligodontia (HP:0000677)3.32649484
23Emphysema (HP:0002097)3.28244077
24Cystic hygroma (HP:0000476)3.21720110
25Hyperaldosteronism (HP:0000859)3.19095736
26Abnormality of chloride homeostasis (HP:0011422)3.18897239
27Abnormality of renin-angiotensin system (HP:0000847)3.13535478
28Ulnar claw (HP:0001178)3.09982644
29Dehydration (HP:0001944)3.03962153
30Renal salt wasting (HP:0000127)2.97500117
31Distal lower limb muscle weakness (HP:0009053)2.85428921
32Obstructive sleep apnea (HP:0002870)2.80152190
33Right ventricular cardiomyopathy (HP:0011663)2.74924869
34Abnormality of the salivary glands (HP:0010286)2.67141753
35Erythema (HP:0010783)2.65936064
36Hypergammaglobulinemia (HP:0010702)2.56789552
37Hoarse voice (HP:0001609)2.47147375
38Complement deficiency (HP:0004431)2.46420261
39Urticaria (HP:0001025)2.36608168
40Papillary thyroid carcinoma (HP:0002895)2.32583916
41Acne (HP:0001061)2.22843426
42Delusions (HP:0000746)2.20787815
43Verrucae (HP:0200043)2.20019765
44Papilloma (HP:0012740)2.20019765
45Adrenal overactivity (HP:0002717)2.19733825
46Aortic aneurysm (HP:0004942)2.15502930
47Abnormality of potassium homeostasis (HP:0011042)2.13701057
48Segmental peripheral demyelination/remyelination (HP:0003481)2.13058513
49Hyporeflexia of lower limbs (HP:0002600)2.09293184
50Hyponatremia (HP:0002902)2.08752495
51Absence seizures (HP:0002121)2.07045104
52Abnormality of complement system (HP:0005339)2.02099915
53Muscle fiber splitting (HP:0003555)2.01056069
54Increased IgE level (HP:0003212)10.3086887
55Nail dystrophy (HP:0008404)1.98579000
56Furrowed tongue (HP:0000221)1.94474217
57Low posterior hairline (HP:0002162)1.93678418
58Bronchitis (HP:0012387)1.86979315
59Choroideremia (HP:0001139)1.86550788
60Skin pits (HP:0100276)1.84581422
61Thoracolumbar scoliosis (HP:0002944)1.82964289
62Thickened nuchal skin fold (HP:0000474)1.80523799
63Autoamputation (HP:0001218)1.75078211
64Seborrheic dermatitis (HP:0001051)1.74937921
65Abnormality of sodium homeostasis (HP:0010931)1.74823657
66Overgrowth (HP:0001548)1.72708690
67Coarse hair (HP:0002208)1.72168517
68Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.71421854
69Aplasia/Hypoplasia of the tongue (HP:0010295)1.70778794
70Stenosis of the external auditory canal (HP:0000402)1.68545642
71Type 1 muscle fiber predominance (HP:0003803)1.67104003
72Muscle fiber inclusion bodies (HP:0100299)1.67097745
73Abnormality of nail color (HP:0100643)1.66993666
74Systemic lupus erythematosus (HP:0002725)1.66179015
75Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.66077196
76Bilateral sensorineural hearing impairment (HP:0008619)1.64670585
77Malnutrition (HP:0004395)1.63525078
78Fine hair (HP:0002213)1.59825906
79Protrusio acetabuli (HP:0003179)1.57991718
80Glomerulonephritis (HP:0000099)1.57157287
81Advanced eruption of teeth (HP:0006288)1.56946624
82Nemaline bodies (HP:0003798)1.55923142
83Skin rash (HP:0000988)1.54604187
84Vascular tortuosity (HP:0004948)1.54232376
85Hypoplastic nipples (HP:0002557)1.53946246
86Oligodactyly (hands) (HP:0001180)1.52820797
87Laryngomalacia (HP:0001601)1.51278205
88Hypoplasia of the iris (HP:0007676)1.50989654
89Abnormality of the fingertips (HP:0001211)1.50638550
90Nephritis (HP:0000123)1.49739032
91Ectropion (HP:0000656)1.49160928
92Foot dorsiflexor weakness (HP:0009027)1.48035474
93Hypokalemia (HP:0002900)1.47819646
94Sleep apnea (HP:0010535)1.46879133
95Lymphedema (HP:0001004)1.46804013
96Asthma (HP:0002099)1.45271611
97Melanocytic nevus (HP:0000995)1.44980598
98Labial hypoplasia (HP:0000066)1.44162693
99Alkalosis (HP:0001948)1.43059470
100Difficulty running (HP:0009046)1.42535842

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.34925043
2RIPK13.35224535
3WNK13.25256135
4CAMK1D2.87351006
5NME12.81560941
6STK392.70508098
7TYRO32.51292670
8SGK22.39974150
9MAP3K22.34503581
10SGK32.29723624
11CAMK1G2.23827604
12LRRK22.07086715
13ERN12.03373388
14TRPM72.03042316
15PIK3CA2.01270245
16MAPKAPK31.95269538
17EPHA21.95262489
18MARK21.90948034
19WNK41.82987894
20SGK4941.76267492
21SGK2231.76267492
22OBSCN1.72576507
23STK241.62052321
24DMPK1.51931597
25PDGFRB1.49500185
26CSK1.47597866
27ERBB31.42199482
28MST41.30001319
29LATS11.26270348
30AKT31.25715682
31MAP3K31.24628243
32HIPK21.15537614
33MAPK151.14583200
34MAP3K71.14174864
35PRKAA21.03284267
36DDR21.02603798
37MAPK70.99856150
38CDK120.98155551
39FER0.97670329
40ICK0.97368075
41TRIB30.94507032
42TAOK10.94383092
43RPS6KA20.93243156
44BCR0.91867734
45IRAK10.89351897
46MAP3K10.84609218
47STK30.83740357
48KSR20.81834533
49STK380.81565606
50EPHB10.80855609
51AKT20.79697583
52MTOR0.79364725
53FGFR10.76686524
54PTK20.75832138
55IKBKE0.74695233
56DAPK20.74173285
57MET0.72635295
58EEF2K0.71866039
59CHUK0.68971817
60SIK10.67076235
61EPHA30.65215236
62NLK0.63468931
63TGFBR20.62208622
64CDK90.61665064
65MAPK10.61186586
66PDGFRA0.60937640
67SGK10.59738258
68MAPK30.58787998
69TBK10.57668117
70RPS6KA10.57496011
71ZAP700.57301367
72CDC42BPA0.56773206
73EPHB20.54557854
74RPS6KB10.52228702
75MAP3K60.52147990
76MAPKAPK20.51627220
77RET0.51596537
78MAP4K20.50506814
79MAP2K10.49903474
80CAMK40.48234774
81RPS6KB20.48118189
82PRKD20.47372936
83SIK30.46542877
84MAP2K20.43288501
85CAMK10.42051550
86OXSR10.40058180
87FGFR30.37915602
88MAPKAPK50.37209808
89IRAK20.36750455
90IRAK40.35152987
91TIE10.35122620
92AKT10.33442080
93PRKD10.33349996
94PRKAA10.32295471
95RPS6KA30.32263199
96RPS6KL10.30801258
97RPS6KC10.30801258
98MAPK40.30297567
99PAK20.29102017
100CDK30.26384034

Predicted pathways (KEGG)

RankGene SetZ-score
1* Salivary secretion_Homo sapiens_hsa049703.99951469
2Circadian rhythm_Homo sapiens_hsa047103.33528520
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.07951763
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.25358234
5Adherens junction_Homo sapiens_hsa045202.15038593
6Notch signaling pathway_Homo sapiens_hsa043301.98911201
7Arachidonic acid metabolism_Homo sapiens_hsa005901.93438848
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63330341
9Amoebiasis_Homo sapiens_hsa051461.56920436
10Malaria_Homo sapiens_hsa051441.56145388
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.53962848
12Acute myeloid leukemia_Homo sapiens_hsa052211.47070410
13Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.43033335
14Dorso-ventral axis formation_Homo sapiens_hsa043201.33236832
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30507059
16Tight junction_Homo sapiens_hsa045301.29195578
17Pertussis_Homo sapiens_hsa051331.27015417
18TNF signaling pathway_Homo sapiens_hsa046681.22750531
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.19424273
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19038811
21Renal cell carcinoma_Homo sapiens_hsa052111.14623217
22Staphylococcus aureus infection_Homo sapiens_hsa051501.14348765
23Prostate cancer_Homo sapiens_hsa052151.09864362
24African trypanosomiasis_Homo sapiens_hsa051431.06175028
25Thyroid cancer_Homo sapiens_hsa052161.05033397
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.03176657
27Insulin resistance_Homo sapiens_hsa049311.02588400
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.02204901
29Influenza A_Homo sapiens_hsa051640.95352050
30GnRH signaling pathway_Homo sapiens_hsa049120.94565349
31Collecting duct acid secretion_Homo sapiens_hsa049660.94439960
32Insulin signaling pathway_Homo sapiens_hsa049100.94049187
33Complement and coagulation cascades_Homo sapiens_hsa046100.93899220
34FoxO signaling pathway_Homo sapiens_hsa040680.93750092
35Vibrio cholerae infection_Homo sapiens_hsa051100.92120661
36Endocytosis_Homo sapiens_hsa041440.91281799
37Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91188677
38Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91074269
39Serotonergic synapse_Homo sapiens_hsa047260.90850033
40Osteoclast differentiation_Homo sapiens_hsa043800.89533344
41Prolactin signaling pathway_Homo sapiens_hsa049170.88679210
42Chemokine signaling pathway_Homo sapiens_hsa040620.88123187
43Hepatitis C_Homo sapiens_hsa051600.87199547
44Focal adhesion_Homo sapiens_hsa045100.85210355
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84484739
46PPAR signaling pathway_Homo sapiens_hsa033200.83212379
47Chronic myeloid leukemia_Homo sapiens_hsa052200.82147965
48ErbB signaling pathway_Homo sapiens_hsa040120.81727300
49Glutathione metabolism_Homo sapiens_hsa004800.81623287
50Renin secretion_Homo sapiens_hsa049240.80747055
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80089236
52Endometrial cancer_Homo sapiens_hsa052130.79902323
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.79804716
54Chemical carcinogenesis_Homo sapiens_hsa052040.79357465
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.78608685
56Salmonella infection_Homo sapiens_hsa051320.77884134
57Choline metabolism in cancer_Homo sapiens_hsa052310.75896171
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.74705054
59Estrogen signaling pathway_Homo sapiens_hsa049150.74036904
60AMPK signaling pathway_Homo sapiens_hsa041520.73600147
61Ras signaling pathway_Homo sapiens_hsa040140.71328550
62Rap1 signaling pathway_Homo sapiens_hsa040150.71262221
63Rheumatoid arthritis_Homo sapiens_hsa053230.70618165
64Glucagon signaling pathway_Homo sapiens_hsa049220.70528137
65Long-term potentiation_Homo sapiens_hsa047200.70316812
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.69598129
67Tuberculosis_Homo sapiens_hsa051520.69292445
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68926024
69Hepatitis B_Homo sapiens_hsa051610.67753154
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67563352
71Pancreatic cancer_Homo sapiens_hsa052120.67087185
72MAPK signaling pathway_Homo sapiens_hsa040100.66365408
73Axon guidance_Homo sapiens_hsa043600.66325346
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.65906489
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65487153
76Pancreatic secretion_Homo sapiens_hsa049720.64664293
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63809480
78Lysine degradation_Homo sapiens_hsa003100.63808445
79Wnt signaling pathway_Homo sapiens_hsa043100.62375110
80Phenylalanine metabolism_Homo sapiens_hsa003600.60958097
81Platelet activation_Homo sapiens_hsa046110.60436147
82Renin-angiotensin system_Homo sapiens_hsa046140.60086676
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59809480
84Pathways in cancer_Homo sapiens_hsa052000.59328000
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59212321
86Leishmaniasis_Homo sapiens_hsa051400.56884718
87Non-small cell lung cancer_Homo sapiens_hsa052230.56423522
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55759707
89Histidine metabolism_Homo sapiens_hsa003400.55239961
90B cell receptor signaling pathway_Homo sapiens_hsa046620.55068211
91VEGF signaling pathway_Homo sapiens_hsa043700.55007205
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54970726
93Gap junction_Homo sapiens_hsa045400.53319440
94TGF-beta signaling pathway_Homo sapiens_hsa043500.52084010
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51012398
96cAMP signaling pathway_Homo sapiens_hsa040240.50629584
97ECM-receptor interaction_Homo sapiens_hsa045120.50426588
98Colorectal cancer_Homo sapiens_hsa052100.50319594
99Inositol phosphate metabolism_Homo sapiens_hsa005620.48623220
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47891969

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