STAU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)5.30102217
2L-phenylalanine catabolic process (GO:0006559)4.93260437
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.93260437
4COPI coating of Golgi vesicle (GO:0048205)4.75139097
5Golgi transport vesicle coating (GO:0048200)4.75139097
6negative regulation of fibrinolysis (GO:0051918)4.69443927
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.64710767
8L-phenylalanine metabolic process (GO:0006558)4.64710767
9pyrimidine nucleobase catabolic process (GO:0006208)4.53630157
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.40791479
11aromatic amino acid family catabolic process (GO:0009074)4.16267870
12proline biosynthetic process (GO:0006561)4.10139120
13glyoxylate metabolic process (GO:0046487)4.09941356
14lysine metabolic process (GO:0006553)4.07913208
15lysine catabolic process (GO:0006554)4.07913208
16regulation of fibrinolysis (GO:0051917)4.05920063
17urea cycle (GO:0000050)4.02530904
18urea metabolic process (GO:0019627)4.02530904
19kynurenine metabolic process (GO:0070189)3.92808860
20cytoplasmic mRNA processing body assembly (GO:0033962)3.91555331
21sulfur amino acid catabolic process (GO:0000098)3.87363837
22very-low-density lipoprotein particle assembly (GO:0034379)3.77752169
23high-density lipoprotein particle remodeling (GO:0034375)3.77290697
24bile acid biosynthetic process (GO:0006699)3.75881566
25positive regulation of fatty acid beta-oxidation (GO:0032000)3.73472788
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.73197400
27nuclear pore complex assembly (GO:0051292)3.71376858
28mitotic chromosome condensation (GO:0007076)3.67872212
29protein carboxylation (GO:0018214)3.61041784
30peptidyl-glutamic acid carboxylation (GO:0017187)3.61041784
31cysteine metabolic process (GO:0006534)3.60873357
32tryptophan catabolic process (GO:0006569)3.59981934
33indole-containing compound catabolic process (GO:0042436)3.59981934
34indolalkylamine catabolic process (GO:0046218)3.59981934
35regulation of protein activation cascade (GO:2000257)3.59517691
36nucleobase catabolic process (GO:0046113)3.53880906
37regulation of fatty acid beta-oxidation (GO:0031998)3.51858828
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.51833628
39nitrogen cycle metabolic process (GO:0071941)3.50281811
40cellular ketone body metabolic process (GO:0046950)3.46479432
41protein retention in ER lumen (GO:0006621)3.46419048
42complement activation, alternative pathway (GO:0006957)3.45618807
43negative regulation of cholesterol transport (GO:0032375)3.44709602
44negative regulation of sterol transport (GO:0032372)3.44709602
45reverse cholesterol transport (GO:0043691)3.43823851
46COPII vesicle coating (GO:0048208)3.41741720
47tryptophan metabolic process (GO:0006568)3.38029287
48regulation of complement activation (GO:0030449)3.34648571
49desmosome organization (GO:0002934)3.27556051
50proline metabolic process (GO:0006560)3.23581030
51arginine metabolic process (GO:0006525)3.21428897
52plasma lipoprotein particle clearance (GO:0034381)3.20135957
53regulation of RNA export from nucleus (GO:0046831)3.19876798
54nuclear pore organization (GO:0006999)3.19798181
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18907137
56mitotic sister chromatid cohesion (GO:0007064)3.18008404
57regulation of triglyceride catabolic process (GO:0010896)3.17663266
58regulation of plasminogen activation (GO:0010755)3.11802787
59ethanol oxidation (GO:0006069)3.04741294
60response to pheromone (GO:0019236)3.04476304
61macroautophagy (GO:0016236)3.01441565
62linoleic acid metabolic process (GO:0043651)3.00616041
63regulation of cholesterol homeostasis (GO:2000188)2.99644252
64DNA unwinding involved in DNA replication (GO:0006268)2.98155504
65uronic acid metabolic process (GO:0006063)2.95269574
66glucuronate metabolic process (GO:0019585)2.95269574
67bile acid metabolic process (GO:0008206)2.95262896
68triglyceride homeostasis (GO:0070328)2.93130714
69acylglycerol homeostasis (GO:0055090)2.93130714
70positive regulation of lipid catabolic process (GO:0050996)2.92932746
71cellular modified amino acid catabolic process (GO:0042219)2.89723296
72negative regulation of lipase activity (GO:0060192)2.89222624
73ketone body metabolic process (GO:1902224)2.87638403
74regulation of cholesterol biosynthetic process (GO:0045540)2.87142070
75midgut development (GO:0007494)2.86637934
76macromolecular complex remodeling (GO:0034367)2.86558062
77plasma lipoprotein particle remodeling (GO:0034369)2.86558062
78protein-lipid complex remodeling (GO:0034368)2.86558062
79tyrosine metabolic process (GO:0006570)2.86062073
80vesicle coating (GO:0006901)2.85827309
81regulation of nucleobase-containing compound transport (GO:0032239)2.84646807
82amino-acid betaine metabolic process (GO:0006577)2.84413039
83protein-lipid complex assembly (GO:0065005)2.83474473
842-oxoglutarate metabolic process (GO:0006103)2.82815126
85positive regulation of fatty acid oxidation (GO:0046321)2.82234247
86epoxygenase P450 pathway (GO:0019373)2.82023687
87homocysteine metabolic process (GO:0050667)2.80950951
88benzene-containing compound metabolic process (GO:0042537)2.78212741
89drug catabolic process (GO:0042737)2.78206987
90negative regulation of lipid transport (GO:0032369)2.76234001
91regulation of mitotic spindle organization (GO:0060236)2.74074019
92regulation of cholesterol esterification (GO:0010872)2.74007988
93heterochromatin organization (GO:0070828)2.73046743
94fibrinolysis (GO:0042730)2.72832003
95paraxial mesoderm development (GO:0048339)2.72784708
96cholesterol efflux (GO:0033344)2.72641529
97spliceosomal tri-snRNP complex assembly (GO:0000244)2.72509128
98regulation of bile acid biosynthetic process (GO:0070857)2.72236106
99intestinal cholesterol absorption (GO:0030299)2.72049887
100alpha-amino acid catabolic process (GO:1901606)2.71936028
101phospholipid efflux (GO:0033700)2.71795224
102protein maturation by protein folding (GO:0022417)2.71681758
103embryonic retina morphogenesis in camera-type eye (GO:0060059)2.71219006
104cellular glucuronidation (GO:0052695)2.71083958
105axon extension involved in axon guidance (GO:0048846)2.68337910
106neuron projection extension involved in neuron projection guidance (GO:1902284)2.68337910
107regulation of transforming growth factor beta2 production (GO:0032909)2.67838269
108plasma lipoprotein particle assembly (GO:0034377)2.66219090
109aromatic amino acid family metabolic process (GO:0009072)2.65462354
110serine family amino acid catabolic process (GO:0009071)2.65182224
111coenzyme catabolic process (GO:0009109)2.63449189
112regulation of mammary gland epithelial cell proliferation (GO:0033599)2.63361996
113negative regulation of protein activation cascade (GO:2000258)2.62195266
114aspartate family amino acid catabolic process (GO:0009068)2.60287039
115protein localization to chromosome, centromeric region (GO:0071459)2.58521191
116protein localization to microtubule (GO:0035372)2.55224667
117hippo signaling (GO:0035329)2.54805416
118indolalkylamine metabolic process (GO:0006586)2.54432198
119positive regulation of DNA-dependent DNA replication (GO:2000105)2.54187569
120positive regulation of hormone metabolic process (GO:0032352)2.53646475
121regulation of cholesterol metabolic process (GO:0090181)2.53117788
122regulation of translational fidelity (GO:0006450)2.52944248
123positive regulation of glycogen biosynthetic process (GO:0045725)2.52657353
124glucose 6-phosphate metabolic process (GO:0051156)2.52484880
125skin morphogenesis (GO:0043589)2.52205030
126body morphogenesis (GO:0010171)2.52048779
127cellular amino acid catabolic process (GO:0009063)2.51499603
1284-hydroxyproline metabolic process (GO:0019471)2.50769722
129bile acid and bile salt transport (GO:0015721)2.50588595
130pore complex assembly (GO:0046931)2.50172460
131regulation of spindle organization (GO:0090224)2.49247422
132complement activation, classical pathway (GO:0006958)2.48439365
133chromosome condensation (GO:0030261)2.47896133
134arginine catabolic process (GO:0006527)2.47479696
135G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.46299253
136regulation of apoptotic cell clearance (GO:2000425)2.45207303
137fatty acid transmembrane transport (GO:1902001)2.45164409
138mitotic sister chromatid segregation (GO:0000070)2.44866724
139monocarboxylic acid catabolic process (GO:0072329)2.44571427
140regulation of fatty acid oxidation (GO:0046320)2.44511269
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42947825
142epithelial cell-cell adhesion (GO:0090136)2.42104988
143mitotic metaphase plate congression (GO:0007080)2.41216602
144basement membrane organization (GO:0071711)2.39603598
145cellular protein complex localization (GO:0034629)2.39352389
146positive regulation of hormone biosynthetic process (GO:0046886)2.38121217
147peptidyl-proline hydroxylation (GO:0019511)2.37450758
148glutamine family amino acid biosynthetic process (GO:0009084)2.35998841
149regulation of early endosome to late endosome transport (GO:2000641)2.33307618
150regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31782399
151bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31615785
152activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.30954478
153positive regulation of nuclease activity (GO:0032075)2.30864857
154blood coagulation, intrinsic pathway (GO:0007597)2.30063140
155lung epithelium development (GO:0060428)2.28951905
156sister chromatid segregation (GO:0000819)2.28036141
157response to vitamin A (GO:0033189)2.27948127
158protein export from nucleus (GO:0006611)2.26925613
159gap junction assembly (GO:0016264)2.26807039
160branching involved in mammary gland duct morphogenesis (GO:0060444)2.26704247
161protein localization to kinetochore (GO:0034501)2.25139889
162regulation of sister chromatid cohesion (GO:0007063)2.24713069
163adherens junction assembly (GO:0034333)2.24697623
164cellular copper ion homeostasis (GO:0006878)2.24404270
165cell-substrate adherens junction assembly (GO:0007045)2.24316073
166focal adhesion assembly (GO:0048041)2.24316073
167notochord development (GO:0030903)2.24053021
168intestinal absorption (GO:0050892)2.23192441
169DNA synthesis involved in DNA repair (GO:0000731)2.22828878
170protein complex localization (GO:0031503)2.21886414
171glucocorticoid receptor signaling pathway (GO:0042921)2.21550736
172DNA packaging (GO:0006323)2.19730475
173regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.19642266
174establishment of integrated proviral latency (GO:0075713)2.19581543
175cochlea morphogenesis (GO:0090103)2.17695177
176cell adhesion mediated by integrin (GO:0033627)2.15874902
177formation of translation preinitiation complex (GO:0001731)2.12155998
178protein hydroxylation (GO:0018126)2.10156457
179positive regulation of cell cycle checkpoint (GO:1901978)2.09971258
180ER-nucleus signaling pathway (GO:0006984)2.09535474
181stress granule assembly (GO:0034063)2.08484853
182NLS-bearing protein import into nucleus (GO:0006607)2.08433090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.75734549
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.00404224
3E2F7_22180533_ChIP-Seq_HELA_Human4.84312909
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.37024973
5* LXR_22158963_ChIP-Seq_LIVER_Mouse3.90718819
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.32515382
7AR_21909140_ChIP-Seq_LNCAP_Human3.26069241
8CLOCK_20551151_ChIP-Seq_293T_Human3.26001139
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.99512683
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80520144
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76313880
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.74929078
13* NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.71908165
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.53346469
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.43034053
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41720848
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.41122258
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.38478834
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.23346384
20ZNF263_19887448_ChIP-Seq_K562_Human2.19481847
21ESR1_21235772_ChIP-Seq_MCF-7_Human2.10698241
22ZFX_18555785_ChIP-Seq_MESCs_Mouse2.06063086
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.01325833
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.01306925
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.96229887
26CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.95756189
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.93775333
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93492104
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.92406245
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90379777
31KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.85197744
32MYC_19079543_ChIP-ChIP_MESCs_Mouse1.84696334
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79155536
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79135081
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78351806
36ESR1_20079471_ChIP-ChIP_T-47D_Human1.76009669
37* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74918589
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74752919
39* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74498042
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.73349259
41KLF4_18555785_ChIP-Seq_MESCs_Mouse1.72979181
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.70351655
43TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68417201
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65058570
45DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.64363582
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64118811
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63293144
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.63147767
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61875898
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60750695
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.60535351
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58804580
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56942757
54FOXA2_19822575_ChIP-Seq_HepG2_Human1.52460713
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.50706299
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49268320
57XRN2_22483619_ChIP-Seq_HELA_Human1.48778127
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47043568
59KDM2B_26808549_Chip-Seq_K562_Human1.45493098
60* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.40169881
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36947092
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.34630302
63KDM2B_26808549_Chip-Seq_DND41_Human1.33921863
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.31648790
65* E2F1_21310950_ChIP-Seq_MCF-7_Human1.30668925
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29330026
67KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28663321
68DCP1A_22483619_ChIP-Seq_HELA_Human1.28353479
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28272674
70SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27488977
71* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27197735
72CHD1_26751641_Chip-Seq_LNCaP_Human1.26384521
73EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26218661
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26086938
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.25636419
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.25305223
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25295865
78TRIM28_21343339_ChIP-Seq_HEK293_Human1.24616059
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.23579811
80* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23078306
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22947056
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22793627
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22279431
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22045125
85GABP_19822575_ChIP-Seq_HepG2_Human1.21405822
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.20030836
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19864391
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19042512
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.18947838
90SOX17_20123909_ChIP-Seq_XEN_Mouse1.18577887
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18502197
92ESR1_15608294_ChIP-ChIP_MCF-7_Human1.18118034
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.17967956
94* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17072189
95GATA6_25053715_ChIP-Seq_YYC3_Human1.16557215
96MYC_22102868_ChIP-Seq_BL_Human1.16349984
97TCF7_22412390_ChIP-Seq_EML_Mouse1.16300902
98HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13961698
99ZNF217_24962896_ChIP-Seq_MCF-7_Human1.13640050
100CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13337557
101CJUN_26792858_Chip-Seq_BT549_Human1.13171407
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12880612
103NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11576132
104CDX2_20551321_ChIP-Seq_CACO-2_Human1.10276930
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10191477
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09337777
107* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.08160525
108TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.07771169
109LXR_22292898_ChIP-Seq_THP-1_Human1.07508411
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06829519
111OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06659448
112* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05829765
113E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05580194
114TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05231460
115EP300_21415370_ChIP-Seq_HL-1_Mouse1.04735702
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04697763
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04538413
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.04413910
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.04413910
120TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03984748
121GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.03758770
122FOXM1_23109430_ChIP-Seq_U2OS_Human1.03449593
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.01580197
124CREB1_26743006_Chip-Seq_LNCaP_Human1.01576112
125CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01387085
126ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00731945
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00545503
128FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00140630
129TTF2_22483619_ChIP-Seq_HELA_Human0.98007790
130BRD4_25478319_ChIP-Seq_HGPS_Human0.94727881
131DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94117377
132* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93306354
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92401845
134SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92385382
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92382717
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91884404
137* HNF4A_19822575_ChIP-Seq_HepG2_Human0.91386626
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91142379
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90256163
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.87581490
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.84841374
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.84838848
143ATF3_27146783_Chip-Seq_COLON_Human0.83412398
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.83334968
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81008504
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.80517156
147ELK4_26923725_Chip-Seq_MESODERM_Mouse0.80431754
148RACK7_27058665_Chip-Seq_MCF-7_Human0.80167408
149ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79795753
150ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.79023089
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.78635138
152CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77511017
153TP53_22127205_ChIP-Seq_IMR90_Human0.76906779
154PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75538248
155* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75443863
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.73852591

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.97950194
2MP0005360_urolithiasis4.54962058
3MP0005365_abnormal_bile_salt4.33578609
4MP0010030_abnormal_orbit_morphology3.95703256
5MP0005085_abnormal_gallbladder_physiolo3.50952495
6MP0003705_abnormal_hypodermis_morpholog3.13346472
7MP0000566_synostosis2.89347447
8MP0008875_abnormal_xenobiotic_pharmacok2.79136952
9MP0010368_abnormal_lymphatic_system2.68343897
10MP0003252_abnormal_bile_duct2.58168960
11MP0005248_abnormal_Harderian_gland2.48011237
12MP0010329_abnormal_lipoprotein_level2.47087043
13MP0003123_paternal_imprinting2.37289312
14MP0005451_abnormal_body_composition2.32003168
15MP0003566_abnormal_cell_adhesion2.31425845
16MP0008438_abnormal_cutaneous_collagen2.21354708
17MP0005409_darkened_coat_color2.16888179
18MP0003693_abnormal_embryo_hatching2.14130003
19MP0009053_abnormal_anal_canal2.09281378
20MP0003111_abnormal_nucleus_morphology2.09172925
21MP0009840_abnormal_foam_cell2.08008047
22MP0004233_abnormal_muscle_weight2.03931396
23MP0004957_abnormal_blastocyst_morpholog1.96946333
24MP0004264_abnormal_extraembryonic_tissu1.95884108
25MP0002877_abnormal_melanocyte_morpholog1.94390410
26MP0001730_embryonic_growth_arrest1.93935594
27MP0010234_abnormal_vibrissa_follicle1.92682869
28MP0003950_abnormal_plasma_membrane1.83587272
29MP0009384_cardiac_valve_regurgitation1.82368798
30MP0002653_abnormal_ependyma_morphology1.76280974
31MP0003941_abnormal_skin_development1.74867531
32MP0008789_abnormal_olfactory_epithelium1.71316240
33MP0008932_abnormal_embryonic_tissue1.67691496
34MP0000678_abnormal_parathyroid_gland1.60835231
35MP0010352_gastrointestinal_tract_polyps1.58842895
36MP0005408_hypopigmentation1.56748034
37MP0003077_abnormal_cell_cycle1.53683441
38MP0002796_impaired_skin_barrier1.52019337
39MP0003315_abnormal_perineum_morphology1.51734842
40MP0000609_abnormal_liver_physiology1.46889217
41MP0002089_abnormal_postnatal_growth/wei1.46316419
42MP0005501_abnormal_skin_physiology1.45370799
43MP0009780_abnormal_chondrocyte_physiolo1.45247548
44MP0001672_abnormal_embryogenesis/_devel1.44512370
45MP0005380_embryogenesis_phenotype1.44512370
46MP0003942_abnormal_urinary_system1.41793316
47MP0001697_abnormal_embryo_size1.41410226
48MP0002249_abnormal_larynx_morphology1.40862466
49MP0003122_maternal_imprinting1.40446059
50MP0005076_abnormal_cell_differentiation1.39667396
51MP0002234_abnormal_pharynx_morphology1.38323676
52MP0005257_abnormal_intraocular_pressure1.35835032
53MP0000350_abnormal_cell_proliferation1.35710247
54MP0008961_abnormal_basal_metabolism1.34490306
55MP0000569_abnormal_digit_pigmentation1.32795514
56MP0005623_abnormal_meninges_morphology1.32580330
57MP0003984_embryonic_growth_retardation1.32001317
58MP0005499_abnormal_olfactory_system1.29631390
59MP0005394_taste/olfaction_phenotype1.29631390
60MP0002080_prenatal_lethality1.29242353
61MP0002084_abnormal_developmental_patter1.26111875
62MP0003115_abnormal_respiratory_system1.26017712
63MP0002088_abnormal_embryonic_growth/wei1.25777250
64MP0003279_aneurysm1.25419930
65MP0005083_abnormal_biliary_tract1.24607609
66MP0002085_abnormal_embryonic_tissue1.23915359
67MP0000733_abnormal_muscle_development1.22671483
68MP0002086_abnormal_extraembryonic_tissu1.21038995
69MP0003385_abnormal_body_wall1.20466931
70MP0005187_abnormal_penis_morphology1.17692804
71MP0003656_abnormal_erythrocyte_physiolo1.16445603
72MP0005023_abnormal_wound_healing1.16424523
73MP0000537_abnormal_urethra_morphology1.15901512
74MP0004272_abnormal_basement_membrane1.13791581
75MP0001666_abnormal_nutrient_absorption1.12491487
76MP0005058_abnormal_lysosome_morphology1.11348270
77MP0002118_abnormal_lipid_homeostasis1.11074302
78MP0000003_abnormal_adipose_tissue1.10316117
79MP0000534_abnormal_ureter_morphology1.09943562
80MP0010094_abnormal_chromosome_stability1.09694727
81MP0002102_abnormal_ear_morphology1.09461972
82MP0001661_extended_life_span1.06606916
83MP0000762_abnormal_tongue_morphology1.06362363
84MP0003453_abnormal_keratinocyte_physiol1.05991111
85MP0003718_maternal_effect1.05292476
86MP0003890_abnormal_embryonic-extraembry1.04187818
87MP0002098_abnormal_vibrissa_morphology1.03896192
88MP0008007_abnormal_cellular_replicative1.03667321
89MP0003329_amyloid_beta_deposits1.03112010
90MP0009697_abnormal_copulation1.02698949
91MP0000767_abnormal_smooth_muscle1.02256261
92MP0003806_abnormal_nucleotide_metabolis1.01046182
93MP0008260_abnormal_autophagy1.00625504
94MP0002282_abnormal_trachea_morphology0.99675588
95MP0005332_abnormal_amino_acid0.99277670
96MP0001915_intracranial_hemorrhage0.98816163
97MP0005319_abnormal_enzyme/_coenzyme0.98035022
98MP0004197_abnormal_fetal_growth/weight/0.97652120
99MP0005197_abnormal_uvea_morphology0.97345201
100MP0003868_abnormal_feces_composition0.94394074
101MP0009703_decreased_birth_body0.93211153
102MP0005670_abnormal_white_adipose0.92814567
103MP0005275_abnormal_skin_tensile0.92532414
104MP0003191_abnormal_cellular_cholesterol0.92436477
105MP0000538_abnormal_urinary_bladder0.90975938
106MP0002168_other_aberrant_phenotype0.90945504
107MP0005220_abnormal_exocrine_pancreas0.90598364
108MP0002092_abnormal_eye_morphology0.90079170
109MP0002233_abnormal_nose_morphology0.89856126
110MP0004185_abnormal_adipocyte_glucose0.89477375
111MP0002295_abnormal_pulmonary_circulatio0.89369347
112MP0004130_abnormal_muscle_cell0.89249870
113MP0005503_abnormal_tendon_morphology0.89160482
114MP0000579_abnormal_nail_morphology0.88617596
115MP0000598_abnormal_liver_morphology0.88093361
116MP0000639_abnormal_adrenal_gland0.87907227
117MP0008995_early_reproductive_senescence0.86595974
118MP0001286_abnormal_eye_development0.86411932
119MP0004782_abnormal_surfactant_physiolog0.86028664
120MP0003755_abnormal_palate_morphology0.85756804
121MP0010630_abnormal_cardiac_muscle0.85447091
122MP0002938_white_spotting0.85277686
123MP0000627_abnormal_mammary_gland0.84170541
124MP0003091_abnormal_cell_migration0.81906152
125MP0002932_abnormal_joint_morphology0.81360855
126MP0000604_amyloidosis0.80642690
127MP0003935_abnormal_craniofacial_develop0.79927084
128MP0001216_abnormal_epidermal_layer0.79540622
129MP0005375_adipose_tissue_phenotype0.79320924
130MP0005621_abnormal_cell_physiology0.79168297
131MP0000467_abnormal_esophagus_morphology0.78711819
132MP0003011_delayed_dark_adaptation0.78538212
133MP0003943_abnormal_hepatobiliary_system0.78295365
134MP0005384_cellular_phenotype0.78219786
135MP0005395_other_phenotype0.77256185
136MP0003567_abnormal_fetal_cardiomyocyte0.76929479
137MP0009672_abnormal_birth_weight0.76912828
138MP0005666_abnormal_adipose_tissue0.75861655
139MP0001299_abnormal_eye_distance/0.75284098
140* MP0003861_abnormal_nervous_system0.75277455
141MP0002896_abnormal_bone_mineralization0.74994991
142MP0005508_abnormal_skeleton_morphology0.74884843
143MP0004883_abnormal_blood_vessel0.74416339
144MP0009278_abnormal_bone_marrow0.74335531
145MP0009250_abnormal_appendicular_skeleto0.73764775
146MP0005647_abnormal_sex_gland0.73755342
147MP0003699_abnormal_female_reproductive0.71564841
148MP0006138_congestive_heart_failure0.71018474
149MP0000428_abnormal_craniofacial_morphol0.70604142
150MP0003121_genomic_imprinting0.70599578
151MP0001119_abnormal_female_reproductive0.70379972
152MP0002697_abnormal_eye_size0.69468804
153MP0002128_abnormal_blood_circulation0.67852384
154MP0002060_abnormal_skin_morphology0.67575348
155MP0003937_abnormal_limbs/digits/tail_de0.66643987
156MP0000647_abnormal_sebaceous_gland0.66639085
157MP0001849_ear_inflammation0.66332562
158MP0001340_abnormal_eyelid_morphology0.65876556
159MP0000778_abnormal_nervous_system0.64013929
160MP0001614_abnormal_blood_vessel0.63210136
161MP0001346_abnormal_lacrimal_gland0.62019943

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.80994244
2Shallow orbits (HP:0000586)4.14126823
3Protrusio acetabuli (HP:0003179)4.02238332
4Hepatoblastoma (HP:0002884)3.84756996
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.78848453
6Xanthomatosis (HP:0000991)3.67323955
7Complement deficiency (HP:0004431)3.62946947
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.60731647
9Short 4th metacarpal (HP:0010044)3.60731647
10Intrahepatic cholestasis (HP:0001406)3.29080183
11Abnormality of the 4th metacarpal (HP:0010012)3.27680811
12Facial hemangioma (HP:0000329)3.27368756
13Hypobetalipoproteinemia (HP:0003563)3.24069195
14Abnormality of monocarboxylic acid metabolism (HP:0010996)2.95940876
15Lymphangioma (HP:0100764)2.89008619
16Ketosis (HP:0001946)2.87944760
17Flat acetabular roof (HP:0003180)2.84374585
18Cholecystitis (HP:0001082)2.81720709
19Abnormal gallbladder physiology (HP:0012438)2.81720709
20Aortic aneurysm (HP:0004942)2.80542412
21Hyperlipoproteinemia (HP:0010980)2.77210610
22Myocardial infarction (HP:0001658)2.65621998
23Increased nuchal translucency (HP:0010880)2.61733870
24Hypolipoproteinemia (HP:0010981)2.60862815
25Peritonitis (HP:0002586)2.57482736
26Prolonged partial thromboplastin time (HP:0003645)2.55453137
27Abnormality of complement system (HP:0005339)2.55299549
28Ankle contracture (HP:0006466)2.54927191
29Hypoalphalipoproteinemia (HP:0003233)2.54416182
30Broad palm (HP:0001169)2.51346324
31Broad metatarsal (HP:0001783)2.47758425
32Mitral stenosis (HP:0001718)2.46172210
33Hyperammonemia (HP:0001987)2.44107711
34Abnormality of carpal bone ossification (HP:0006257)2.42420671
35Asymmetry of the thorax (HP:0001555)2.40338613
36Epidermoid cyst (HP:0200040)2.40286057
37Ketoacidosis (HP:0001993)2.39739106
38Back pain (HP:0003418)2.38728154
39Abnormality of glycolysis (HP:0004366)2.36526257
40Aortic dissection (HP:0002647)2.36361690
41Increased density of long bones (HP:0006392)2.35330899
42Heterotopia (HP:0002282)2.35210280
43Deviation of the thumb (HP:0009603)2.34139315
44Small epiphyses (HP:0010585)2.31949271
45Camptodactyly of toe (HP:0001836)2.30448036
46Hypoplasia of the capital femoral epiphysis (HP:0003090)2.28387185
47Right ventricular cardiomyopathy (HP:0011663)2.27911448
48Cortical dysplasia (HP:0002539)2.27484698
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.25333403
50Hypercholesterolemia (HP:0003124)2.23092502
51Abnormality of the metopic suture (HP:0005556)2.22961758
52Abnormality of the aortic arch (HP:0012303)2.22637523
53Broad alveolar ridges (HP:0000187)2.22573255
54Aneurysm (HP:0002617)2.21855330
55Cerebral aneurysm (HP:0004944)2.20749786
56Proximal placement of thumb (HP:0009623)2.20696907
57Abnormality of the Achilles tendon (HP:0005109)2.20264482
58Overlapping toe (HP:0001845)2.19462458
59Insidious onset (HP:0003587)2.19456259
60Termporal pattern (HP:0011008)2.19456259
61Vascular calcification (HP:0004934)2.19104458
62Premature rupture of membranes (HP:0001788)2.18065694
63Acanthocytosis (HP:0001927)2.16858552
64Hyperglycemia (HP:0003074)2.16461984
65Long toe (HP:0010511)2.15736205
66Wrist flexion contracture (HP:0001239)2.15438298
67Biconcave vertebral bodies (HP:0004586)2.10247396
68Gout (HP:0001997)2.09397155
69Abnormality of the acetabulum (HP:0003170)2.08950740
70Bladder diverticulum (HP:0000015)2.08531050
71Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08209386
72Abnormality of sulfur amino acid metabolism (HP:0004339)2.07447193
73Trigonocephaly (HP:0000243)2.06903586
74Insomnia (HP:0100785)2.06479123
75Disproportionate tall stature (HP:0001519)2.06052585
76Arterial tortuosity (HP:0005116)2.05088369
77Abnormality of pain sensation (HP:0010832)2.04459903
78Impaired pain sensation (HP:0007328)2.04459903
79Skin nodule (HP:0200036)2.04384246
80Abnormality of the labia minora (HP:0012880)2.04020688
81Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03952455
82Abnormality of the common coagulation pathway (HP:0010990)2.03633724
83Coronal craniosynostosis (HP:0004440)2.03248414
84Abnormal ossification of hand bones (HP:0005921)2.03039221
85Increased serum pyruvate (HP:0003542)2.02462551
86Mitral valve prolapse (HP:0001634)2.01269541
87Septate vagina (HP:0001153)2.00999627
88Reticulocytosis (HP:0001923)1.98387782
89Cardiovascular calcification (HP:0011915)1.98164169
90Hyperglycinemia (HP:0002154)1.98120994
91Vascular tortuosity (HP:0004948)1.96099891
92Enlarged penis (HP:0000040)1.95833799
93Pseudobulbar signs (HP:0002200)1.95795598
94Striae distensae (HP:0001065)1.95769340
95Abnormality of the intrinsic pathway (HP:0010989)1.92941155
96Osteomalacia (HP:0002749)1.92022669
97Vertebral compression fractures (HP:0002953)1.91344893
98Oligodactyly (HP:0012165)1.90285070
99Achilles tendon contracture (HP:0001771)1.89603576
100Hypoplastic labia majora (HP:0000059)1.88924877
101Hand muscle atrophy (HP:0009130)1.88292581
102Joint hemorrhage (HP:0005261)1.87666939
103Hallux valgus (HP:0001822)1.86812288
104Renovascular hypertension (HP:0100817)1.86606673
105Polycythemia (HP:0001901)1.84982157
106Abnormality of serine family amino acid metabolism (HP:0010894)1.84840669
107Abnormality of glycine metabolism (HP:0010895)1.84840669
108Hyperacusis (HP:0010780)1.84699776
109Deviation of the hallux (HP:0010051)1.84498076
110Papillary thyroid carcinoma (HP:0002895)1.84173809
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83175266
112Advanced eruption of teeth (HP:0006288)1.82824454
113Absent epiphyses (HP:0010577)1.82821491
114Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82821491
115Opisthotonus (HP:0002179)1.81443554
116Menorrhagia (HP:0000132)1.80546709
117Abnormal tarsal ossification (HP:0008369)1.79195933
118Turricephaly (HP:0000262)1.78960820
119Soft skin (HP:0000977)1.77998451
120Neonatal death (HP:0003811)1.77902037
121Pterygium (HP:0001059)1.77805118
122Abnormal hand bone ossification (HP:0010660)1.77234233
123Systemic lupus erythematosus (HP:0002725)1.77018534
124Vertebral arch anomaly (HP:0008438)1.76643379
125Limited elbow extension (HP:0001377)1.74437958
126Abnormality of the peritoneum (HP:0002585)1.74182072
127Renal duplication (HP:0000075)1.74006135
128Abnormality of the labia majora (HP:0012881)1.73957624
129Ectopia lentis (HP:0001083)1.72373448
130Abnormality of the anterior chamber (HP:0000593)1.71472464
131Abnormality of the diencephalon (HP:0010662)1.71244554
132Esophageal varix (HP:0002040)1.71018875
133Abnormality of fatty-acid metabolism (HP:0004359)1.71008166
134Hemorrhage of the eye (HP:0011885)1.70815237
135Conjugated hyperbilirubinemia (HP:0002908)1.70635122
136Abnormality of the phalanges of the hallux (HP:0010057)1.70298162
137Bifid scrotum (HP:0000048)1.68419123
138Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68375952
139Wide cranial sutures (HP:0010537)1.68373627
140Neoplasm of the heart (HP:0100544)1.68362383
141Hepatocellular carcinoma (HP:0001402)1.68039915
142Short 1st metacarpal (HP:0010034)1.67849933
143Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.67849933
144Nephroblastoma (Wilms tumor) (HP:0002667)1.67625340
145Chorioretinal atrophy (HP:0000533)1.67177299
146Distal upper limb amyotrophy (HP:0007149)1.66877158
147Upper limb amyotrophy (HP:0009129)1.66877158
148Capillary hemangiomas (HP:0005306)1.64986016
149Microglossia (HP:0000171)1.64940774
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.64697894
151Arnold-Chiari malformation (HP:0002308)1.64149148
152Ulnar bowing (HP:0003031)1.63729472
153Abnormal delivery (HP:0001787)1.62691926
154Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62161529
155Ankyloglossia (HP:0010296)1.59058893
156Long palpebral fissure (HP:0000637)1.58381824
157Trismus (HP:0000211)1.56409090
158Uterine leiomyosarcoma (HP:0002891)1.55210322
159Leiomyosarcoma (HP:0100243)1.55210322
160Abnormal ventriculo-arterial connection (HP:0011563)1.54174286
161Transposition of the great arteries (HP:0001669)1.54174286
162Abnormal connection of the cardiac segments (HP:0011545)1.54174286
163Embryonal renal neoplasm (HP:0011794)1.53321954
164Overriding aorta (HP:0002623)1.51909682
165Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.51861189
166Glomerulosclerosis (HP:0000096)1.50364640
167Abnormality of the gastric mucosa (HP:0004295)1.48483367
168Abnormality of dentin (HP:0010299)1.47483248
169Shoulder girdle muscle weakness (HP:0003547)1.47419021

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.05306868
2LATS13.62346818
3TRIB33.52431919
4EPHA23.28973656
5PKN22.86430384
6FGFR42.81798100
7EPHB22.77705954
8LATS22.69990113
9SIK12.50182895
10MAP3K102.36367805
11EIF2AK12.33617297
12MST1R2.24773861
13SMG12.23101498
14EPHA32.05846014
15CDK122.03884129
16PDGFRA2.00876960
17TTK1.93533872
18BCKDK1.87418389
19KSR11.73235089
20STK38L1.69537362
21EEF2K1.69508120
22MARK11.64956703
23SIK31.61859151
24BRSK11.57850018
25SCYL21.56027673
26CDK71.55290338
27IRAK31.52001441
28TSSK61.49891319
29TGFBR21.47926592
30NEK11.47838289
31ERBB41.39724737
32MTOR1.36098725
33WNK31.33693207
34TGFBR11.33454444
35ERBB21.32778430
36TESK11.30851764
37LMTK21.29560957
38SRPK11.27221486
39DYRK1B1.25683192
40KSR21.25660542
41DYRK21.24165170
42WEE11.22825485
43FGFR21.22433050
44RET1.22365857
45PNCK1.21912016
46WNK41.20604220
47DMPK1.20132544
48RPS6KB21.12313519
49BCR1.11047874
50TYRO31.10920791
51PTK21.10337680
52PBK1.07982217
53FGFR31.07966714
54TAOK11.06851740
55TAOK31.06486082
56PTK61.06225793
57NTRK11.02597431
58TTN1.00128949
59PAK60.98239642
60DDR20.96672979
61BUB10.94887046
62ICK0.94715870
63BMPR1B0.93851318
64EPHB10.93201909
65STK100.93082111
66STK240.92815927
67PAK30.92293309
68FLT30.91976516
69PAK20.85709598
70NEK20.85557951
71CDK60.83732346
72STK30.83437165
73MAP3K20.83431514
74PDGFRB0.83212756
75MAPK110.82216863
76TBK10.81419415
77WNK10.81363516
78CHEK10.80620209
79BRD40.80446836
80CDC70.79586337
81PLK10.77747965
82BRAF0.77172498
83LIMK10.77137435
84FER0.76555121
85CDK90.76263030
86CAMK1G0.75931831
87ARAF0.74563621
88AURKA0.73760303
89CSF1R0.71626540
90CSNK1E0.69614759
91MAP2K40.69022898
92PDK20.68900306
93CHEK20.68738740
94STK390.67446378
95MAP3K90.65985044
96NME20.64432417
97LRRK20.63944990
98AKT20.61497609
99CDK11A0.61441699
100CDK180.60256458
101KIT0.60081187
102MAP3K80.59964778
103CDK150.59142600
104CDK140.58499498
105MAP3K60.58431552
106DYRK1A0.57852227
107MARK20.57708848
108MET0.57697915
109CDK80.56434907
110BMX0.56352694
111FGFR10.56330243
112ROCK10.55941752
113CAMK1D0.55855660
114NEK90.55409539
115MAPKAPK50.55155211
116AURKB0.55136565
117BRSK20.54408125
118PRKAA10.53982007
119STK380.53555182
120MAP2K10.53353538
121PHKG20.53102725
122PHKG10.53102725
123MELK0.53045411
124CDK10.53022914
125PLK30.51885010
126RIPK10.51688351
127TRIM280.51619765
128TYK20.51384847
129MINK10.51059823
130NEK60.50792839
131CLK10.50635191
132IRAK20.50548162
133CDK30.50286481
134AKT30.50175503
135CAMK40.49846276
136PRKCZ0.49553845
137CDK20.49455980
138RPS6KA20.48377036
139PRKD30.47361595
140PAK40.46773540
141CHUK0.44759373
142CDK40.44682289
143PRKD10.43795830
144PIK3CG0.43488354
145CSNK1A1L0.43156904
146RPS6KA40.43023884
147NTRK20.42456538
148ERBB30.41588689
149MST40.41139300
150MAPKAPK30.40193284
151ATM0.39988208
152MAPK150.38503200
153INSRR0.37819186
154SGK2230.34647782
155SGK4940.34647782
156MAPK10.34521310
157UHMK10.34257672
158MAP3K50.34073113

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.66495148
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.20974511
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.94582774
4Nitrogen metabolism_Homo sapiens_hsa009102.58766988
5Fatty acid degradation_Homo sapiens_hsa000712.53301423
6Arginine biosynthesis_Homo sapiens_hsa002202.51056757
7Complement and coagulation cascades_Homo sapiens_hsa046102.43027371
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.41008849
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40840445
10Tryptophan metabolism_Homo sapiens_hsa003802.34798650
11Butanoate metabolism_Homo sapiens_hsa006502.24922493
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20979596
13Fatty acid metabolism_Homo sapiens_hsa012122.04982786
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.99889073
15Lysine degradation_Homo sapiens_hsa003101.90115266
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.87018068
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85875568
18PPAR signaling pathway_Homo sapiens_hsa033201.80303035
19Thyroid cancer_Homo sapiens_hsa052161.70650812
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.66623456
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64451130
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.63693363
23Propanoate metabolism_Homo sapiens_hsa006401.61088043
24Cell cycle_Homo sapiens_hsa041101.59925278
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51339165
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49698699
27Peroxisome_Homo sapiens_hsa041461.47066458
28Caffeine metabolism_Homo sapiens_hsa002321.46862586
29Vitamin B6 metabolism_Homo sapiens_hsa007501.43411642
30Selenocompound metabolism_Homo sapiens_hsa004501.40216598
31DNA replication_Homo sapiens_hsa030301.38099353
32Pentose phosphate pathway_Homo sapiens_hsa000301.35934635
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34137064
34Staphylococcus aureus infection_Homo sapiens_hsa051501.31903429
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30798434
36Fructose and mannose metabolism_Homo sapiens_hsa000511.30178015
37Chemical carcinogenesis_Homo sapiens_hsa052041.27092501
38mRNA surveillance pathway_Homo sapiens_hsa030151.26579295
39RNA transport_Homo sapiens_hsa030131.21766519
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.19261339
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.15765280
42Mismatch repair_Homo sapiens_hsa034301.14840919
43Retinol metabolism_Homo sapiens_hsa008301.13542334
44Vibrio cholerae infection_Homo sapiens_hsa051101.11569224
45Biosynthesis of amino acids_Homo sapiens_hsa012301.09961938
46Galactose metabolism_Homo sapiens_hsa000521.08656699
47Bile secretion_Homo sapiens_hsa049761.08328619
48Base excision repair_Homo sapiens_hsa034101.07937278
49Pyruvate metabolism_Homo sapiens_hsa006201.06846476
50Notch signaling pathway_Homo sapiens_hsa043301.04190279
51Spliceosome_Homo sapiens_hsa030401.04132741
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.01850798
53N-Glycan biosynthesis_Homo sapiens_hsa005100.99496970
54beta-Alanine metabolism_Homo sapiens_hsa004100.97677758
55One carbon pool by folate_Homo sapiens_hsa006700.96903040
56Basal cell carcinoma_Homo sapiens_hsa052170.95104708
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94438296
58Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93000666
59Tight junction_Homo sapiens_hsa045300.91738750
60Nucleotide excision repair_Homo sapiens_hsa034200.89345708
61Starch and sucrose metabolism_Homo sapiens_hsa005000.88933904
62Fat digestion and absorption_Homo sapiens_hsa049750.87823483
63Insulin resistance_Homo sapiens_hsa049310.87432538
64Pancreatic cancer_Homo sapiens_hsa052120.86951027
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.85524362
66Ovarian steroidogenesis_Homo sapiens_hsa049130.83391638
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81032595
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80921821
69Carbon metabolism_Homo sapiens_hsa012000.79915175
70Histidine metabolism_Homo sapiens_hsa003400.78345990
71Chronic myeloid leukemia_Homo sapiens_hsa052200.78135570
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77113906
73Oocyte meiosis_Homo sapiens_hsa041140.75649108
74AMPK signaling pathway_Homo sapiens_hsa041520.75202579
75Steroid biosynthesis_Homo sapiens_hsa001000.73515867
76ErbB signaling pathway_Homo sapiens_hsa040120.72988570
77Prostate cancer_Homo sapiens_hsa052150.72679786
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72567577
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72482896
80Fatty acid elongation_Homo sapiens_hsa000620.71734269
81Bladder cancer_Homo sapiens_hsa052190.71207521
82Prion diseases_Homo sapiens_hsa050200.68190843
83Axon guidance_Homo sapiens_hsa043600.68027485
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66567276
85Glycerolipid metabolism_Homo sapiens_hsa005610.66398425
86Hippo signaling pathway_Homo sapiens_hsa043900.65141015
87Wnt signaling pathway_Homo sapiens_hsa043100.64894621
88Adherens junction_Homo sapiens_hsa045200.63556953
89ABC transporters_Homo sapiens_hsa020100.63119641
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.62628636
91Colorectal cancer_Homo sapiens_hsa052100.62395029
92Glioma_Homo sapiens_hsa052140.62365609
93Hedgehog signaling pathway_Homo sapiens_hsa043400.61955205
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60524004
95Arginine and proline metabolism_Homo sapiens_hsa003300.60188934
96Non-homologous end-joining_Homo sapiens_hsa034500.59931476
97Tyrosine metabolism_Homo sapiens_hsa003500.59639708
98Proteoglycans in cancer_Homo sapiens_hsa052050.59309513
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.59186762
100mTOR signaling pathway_Homo sapiens_hsa041500.57274771
101Sulfur relay system_Homo sapiens_hsa041220.56258014
102Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54869531
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54531501
104MicroRNAs in cancer_Homo sapiens_hsa052060.54356719
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53937035
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.53217512
107Insulin signaling pathway_Homo sapiens_hsa049100.52712030
108Folate biosynthesis_Homo sapiens_hsa007900.52370110
109Renal cell carcinoma_Homo sapiens_hsa052110.51169678
110TGF-beta signaling pathway_Homo sapiens_hsa043500.50277376
111Circadian rhythm_Homo sapiens_hsa047100.49695838
112p53 signaling pathway_Homo sapiens_hsa041150.49643871
113Glutathione metabolism_Homo sapiens_hsa004800.49163361
114Thyroid hormone synthesis_Homo sapiens_hsa049180.48741590
115Focal adhesion_Homo sapiens_hsa045100.46230232
116ECM-receptor interaction_Homo sapiens_hsa045120.44986758
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44707967
118Non-small cell lung cancer_Homo sapiens_hsa052230.44466827
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44219854
120Sphingolipid metabolism_Homo sapiens_hsa006000.44049404
121Amoebiasis_Homo sapiens_hsa051460.43992487
122VEGF signaling pathway_Homo sapiens_hsa043700.43577788
123Phenylalanine metabolism_Homo sapiens_hsa003600.43518115
124Small cell lung cancer_Homo sapiens_hsa052220.42670661
125Prolactin signaling pathway_Homo sapiens_hsa049170.42347063
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42178340
127Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41832886
128Endometrial cancer_Homo sapiens_hsa052130.41486677
129Glucagon signaling pathway_Homo sapiens_hsa049220.41145017
130Fatty acid biosynthesis_Homo sapiens_hsa000610.38722964
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36227676
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34413592
133Viral myocarditis_Homo sapiens_hsa054160.33938397
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33701669
135Dorso-ventral axis formation_Homo sapiens_hsa043200.32109875
136FoxO signaling pathway_Homo sapiens_hsa040680.31932953
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31893668
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.31374183
139Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31045805
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31028878
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.30379201

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