STAU2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.52391373
2synaptic vesicle exocytosis (GO:0016079)5.28491057
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.21434902
4locomotory exploration behavior (GO:0035641)5.17208234
5vocalization behavior (GO:0071625)5.15789666
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.12330244
7synaptic vesicle maturation (GO:0016188)5.10897274
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.06577723
9glutamate secretion (GO:0014047)4.94448145
10regulation of glutamate receptor signaling pathway (GO:1900449)4.89506770
11neuron cell-cell adhesion (GO:0007158)4.86275248
12regulation of synaptic vesicle exocytosis (GO:2000300)4.73980544
13protein localization to synapse (GO:0035418)4.70303710
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.53324353
15pyrimidine nucleobase catabolic process (GO:0006208)4.48984443
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.32811076
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.30196981
18exploration behavior (GO:0035640)4.29938229
19regulation of synaptic vesicle transport (GO:1902803)4.25539749
20neurotransmitter secretion (GO:0007269)4.24752454
21neuronal action potential propagation (GO:0019227)4.23458796
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.03755210
23layer formation in cerebral cortex (GO:0021819)4.03677585
24regulation of synapse structural plasticity (GO:0051823)3.99955316
25regulation of neuronal synaptic plasticity (GO:0048168)3.93696609
26nucleobase catabolic process (GO:0046113)3.93049465
27glutamate receptor signaling pathway (GO:0007215)3.90781414
28synaptic transmission, glutamatergic (GO:0035249)3.82961271
29neuron recognition (GO:0008038)3.81899908
30proline transport (GO:0015824)3.80839641
31neuron-neuron synaptic transmission (GO:0007270)3.79389393
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72350590
33neurotransmitter-gated ion channel clustering (GO:0072578)3.71202324
34dendritic spine morphogenesis (GO:0060997)3.69208960
35activation of protein kinase A activity (GO:0034199)3.66182368
36postsynaptic membrane organization (GO:0001941)3.61854710
37regulation of excitatory postsynaptic membrane potential (GO:0060079)3.58524953
38gamma-aminobutyric acid transport (GO:0015812)3.51154119
39regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47430431
40positive regulation of membrane potential (GO:0045838)3.47368911
41axonal fasciculation (GO:0007413)3.45697473
42presynaptic membrane assembly (GO:0097105)3.43884600
43regulation of postsynaptic membrane potential (GO:0060078)3.43663596
44long-term memory (GO:0007616)3.42914765
45neurotransmitter transport (GO:0006836)3.39415695
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.37024623
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35810846
48positive regulation of synapse maturation (GO:0090129)3.35371197
49regulation of dendritic spine morphogenesis (GO:0061001)3.32421817
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31669908
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30526461
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.25777368
53regulation of synaptic plasticity (GO:0048167)3.25130824
54cellular potassium ion homeostasis (GO:0030007)3.22645082
55synaptic vesicle endocytosis (GO:0048488)3.20063500
56regulation of neurotransmitter levels (GO:0001505)3.19291597
57regulation of neurotransmitter secretion (GO:0046928)3.18764754
58regulation of vesicle fusion (GO:0031338)3.18311265
59detection of calcium ion (GO:0005513)3.18285757
60cerebellar Purkinje cell differentiation (GO:0021702)3.18194457
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.16729843
62long-term synaptic potentiation (GO:0060291)3.16700795
63transmission of nerve impulse (GO:0019226)3.15655292
64presynaptic membrane organization (GO:0097090)3.13872444
65dendrite morphogenesis (GO:0048813)3.12856688
66regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.12233372
67cell communication by electrical coupling (GO:0010644)3.09601887
68vesicle transport along microtubule (GO:0047496)3.07226864
69membrane depolarization during action potential (GO:0086010)3.06511921
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.05991100
71regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.04031372
72membrane depolarization (GO:0051899)3.02388683
73establishment of mitochondrion localization (GO:0051654)3.00452486
74neuromuscular process controlling balance (GO:0050885)2.98154215
75cell migration in hindbrain (GO:0021535)2.97933346
76C4-dicarboxylate transport (GO:0015740)2.97389621
77regulation of cell communication by electrical coupling (GO:0010649)2.96142210
78response to histamine (GO:0034776)2.95598736
79regulation of neurotransmitter transport (GO:0051588)2.95412298
80synapse assembly (GO:0007416)2.95284554
81innervation (GO:0060384)2.94189121
82behavioral defense response (GO:0002209)2.92564817
83behavioral fear response (GO:0001662)2.92564817
84G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91161344
85positive regulation of neurotransmitter transport (GO:0051590)2.90892540
86organelle transport along microtubule (GO:0072384)2.89763647
87auditory behavior (GO:0031223)2.89526998
88positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.89075544
89positive regulation of neurotransmitter secretion (GO:0001956)2.88994694
90regulation of dendritic spine development (GO:0060998)2.88473468
91regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.88439461
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.87511153
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86867754
94startle response (GO:0001964)2.85996232
95social behavior (GO:0035176)2.85626906
96intraspecies interaction between organisms (GO:0051703)2.85626906
97learning (GO:0007612)2.85488428
98synaptic transmission (GO:0007268)2.85159831
99prepulse inhibition (GO:0060134)2.84305336
100membrane hyperpolarization (GO:0060081)2.83909112
101positive regulation of synapse assembly (GO:0051965)2.83219622
102regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.82164553
103positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.82151036
104DNA double-strand break processing (GO:0000729)2.82090152
105positive regulation of dendritic spine morphogenesis (GO:0061003)2.81885889
106regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.81724446
107response to auditory stimulus (GO:0010996)2.79884505
108positive regulation of mitochondrial fission (GO:0090141)2.79488728
109behavioral response to nicotine (GO:0035095)2.72591807
110central nervous system projection neuron axonogenesis (GO:0021952)2.72459878
111mechanosensory behavior (GO:0007638)2.72451227
112neural tube formation (GO:0001841)2.67617198
113protein neddylation (GO:0045116)2.63220684
114regulation of sarcomere organization (GO:0060297)2.59219857
115nonmotile primary cilium assembly (GO:0035058)2.58387154
116neuromuscular synaptic transmission (GO:0007274)2.58275865
117sarcoplasmic reticulum calcium ion transport (GO:0070296)2.57857316
118negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54968697
119calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.53813225
120cerebral cortex radially oriented cell migration (GO:0021799)2.51644919
121ribonucleoprotein complex disassembly (GO:0032988)2.48553521
122regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.46277049
123regulation of membrane repolarization (GO:0060306)2.43814022
124regulation of acyl-CoA biosynthetic process (GO:0050812)2.40765443
125negative regulation of heart rate (GO:0010459)2.40750890
126regulation of relaxation of muscle (GO:1901077)2.39638453
127glycosphingolipid biosynthetic process (GO:0006688)2.39324175
128negative regulation of neurotransmitter transport (GO:0051589)2.37188131
129negative regulation of DNA recombination (GO:0045910)2.37176848
130response to pheromone (GO:0019236)2.35514100
131regulation of cilium movement (GO:0003352)2.35213544
132regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.34637401
133neurotransmitter uptake (GO:0001504)2.32307488
134synapse organization (GO:0050808)2.30009039
135cullin deneddylation (GO:0010388)2.25581160
136limb bud formation (GO:0060174)2.24701113
137regulation of coenzyme metabolic process (GO:0051196)2.24135748
138regulation of cofactor metabolic process (GO:0051193)2.24135748
139negative regulation of response to food (GO:0032096)2.23929877
140negative regulation of appetite (GO:0032099)2.23929877
141muscle filament sliding (GO:0030049)2.23889133
142actin-myosin filament sliding (GO:0033275)2.23889133
143regulation of voltage-gated calcium channel activity (GO:1901385)2.22776102
144regulation of cAMP-dependent protein kinase activity (GO:2000479)2.22583144
145microtubule anchoring (GO:0034453)2.21379327
146mitochondrion transport along microtubule (GO:0047497)2.20859923
147establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.20859923
148adult walking behavior (GO:0007628)2.19487584

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09178724
2GBX2_23144817_ChIP-Seq_PC3_Human3.69494885
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09380554
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02932123
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.97921367
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66014489
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66014489
8REST_21632747_ChIP-Seq_MESCs_Mouse2.59256582
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57178581
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54431608
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.53304102
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.49765024
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48129754
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.45486667
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41809745
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39995435
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.33374650
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.21552206
19DROSHA_22980978_ChIP-Seq_HELA_Human2.19287457
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13454376
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.11618689
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11307364
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.09584621
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07676803
25TAF15_26573619_Chip-Seq_HEK293_Human2.01675630
26HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99105125
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92674258
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92662434
29EWS_26573619_Chip-Seq_HEK293_Human1.90349049
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89448439
31* FLI1_27457419_Chip-Seq_LIVER_Mouse1.88840536
32* AR_21572438_ChIP-Seq_LNCaP_Human1.88158248
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.86244481
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80996488
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80837796
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.76073834
37ZNF274_21170338_ChIP-Seq_K562_Hela1.62202043
38* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61699173
39* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57738860
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56240906
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54745306
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54744593
43* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52166631
44P300_19829295_ChIP-Seq_ESCs_Human1.50173214
45* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.46945879
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46479909
47E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46070221
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.45931074
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.41964422
50* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41815206
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41353882
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.40954856
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40704172
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.40414444
55* NANOG_18555785_Chip-Seq_ESCs_Mouse1.39861393
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38671051
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37077221
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.36259004
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.35938077
60* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33823895
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33304316
62* PIAS1_25552417_ChIP-Seq_VCAP_Human1.32782453
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32272200
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32150411
65* EZH2_27294783_Chip-Seq_NPCs_Mouse1.31343966
66CBP_20019798_ChIP-Seq_JUKART_Human1.31063937
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31063937
68IGF1R_20145208_ChIP-Seq_DFB_Human1.30975854
69POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30877627
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30660700
71* AR_25329375_ChIP-Seq_VCAP_Human1.30552496
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28690939
73STAT3_23295773_ChIP-Seq_U87_Human1.28481933
74SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27463610
75IRF1_19129219_ChIP-ChIP_H3396_Human1.27129774
76* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24910610
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24461084
78* P53_22387025_ChIP-Seq_ESCs_Mouse1.22142408
79PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22050939
80RNF2_27304074_Chip-Seq_NSC_Mouse1.21881511
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21580725
82* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21500566
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21310889
84* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21119408
85AR_19668381_ChIP-Seq_PC3_Human1.19911743
86* E2F1_18555785_Chip-Seq_ESCs_Mouse1.17720658
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16706870
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.16482933
89SOX9_26525672_Chip-Seq_HEART_Mouse1.15403140
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14975518
91TAL1_26923725_Chip-Seq_HPCs_Mouse1.14927175
92RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14405751
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14196848
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.14144068
95FUS_26573619_Chip-Seq_HEK293_Human1.13958505
96* NFE2_27457419_Chip-Seq_LIVER_Mouse1.13346096
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13144674
98HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12296970
99* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12003290
100* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11824797
101* ARNT_22903824_ChIP-Seq_MCF-7_Human1.11646602
102* TCF4_23295773_ChIP-Seq_U87_Human1.10444035
103YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10255476
104VDR_22108803_ChIP-Seq_LS180_Human1.08207388
105* RING1B_27294783_Chip-Seq_NPCs_Mouse1.07512799
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07184719
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07167774
108SOX2_19829295_ChIP-Seq_ESCs_Human1.06800178
109NANOG_19829295_ChIP-Seq_ESCs_Human1.06800178
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05768394
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05706480
112* AHR_22903824_ChIP-Seq_MCF-7_Human1.05620761
113* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05478830
114* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04447181
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04390005
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04380994
117POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04380994
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03964350
119* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02978337
120* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02810667
121* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02211869
122* RUNX2_22187159_ChIP-Seq_PCA_Human1.01939413
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01047881
124WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.00952904
125* TCF4_22108803_ChIP-Seq_LS180_Human1.00763789
126* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00071890
127* CRX_20693478_ChIP-Seq_RETINA_Mouse0.99884473
128TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99222305
129HTT_18923047_ChIP-ChIP_STHdh_Human0.99013284
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98239733
131PRDM14_20953172_ChIP-Seq_ESCs_Human0.97286521
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96267295
133CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95775453
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.95213849
135ER_23166858_ChIP-Seq_MCF-7_Human0.94688503
136BCAT_22108803_ChIP-Seq_LS180_Human0.94646193
137JUN_21703547_ChIP-Seq_K562_Human0.93550444
138DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92871413
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92201080
140TP53_16413492_ChIP-PET_HCT116_Human0.91532439
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91469903
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.90526546
143EP300_21415370_ChIP-Seq_HL-1_Mouse0.89897885
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88914783

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.81369801
2MP0003880_abnormal_central_pattern4.74700263
3MP0003635_abnormal_synaptic_transmissio3.89706306
4MP0004270_analgesia3.66069951
5MP0009745_abnormal_behavioral_response3.14803328
6MP0002063_abnormal_learning/memory/cond3.14285422
7MP0001968_abnormal_touch/_nociception2.91612432
8MP0002064_seizures2.89665117
9MP0009046_muscle_twitch2.83332735
10MP0002572_abnormal_emotion/affect_behav2.65178201
11MP0002734_abnormal_mechanical_nocicepti2.58282654
12MP0005423_abnormal_somatic_nervous2.55510498
13MP0008877_abnormal_DNA_methylation2.50361420
14MP0002272_abnormal_nervous_system2.41056327
15MP0001486_abnormal_startle_reflex2.34864379
16MP0002735_abnormal_chemical_nociception2.29832825
17MP0002736_abnormal_nociception_after2.29725039
18MP0001501_abnormal_sleep_pattern2.09844902
19MP0009780_abnormal_chondrocyte_physiolo2.09013016
20MP0001440_abnormal_grooming_behavior2.06296464
21MP0002822_catalepsy2.05921003
22MP0002733_abnormal_thermal_nociception2.01494633
23MP0006276_abnormal_autonomic_nervous1.95930389
24MP0002837_dystrophic_cardiac_calcinosis1.95433481
25MP0002067_abnormal_sensory_capabilities1.95417658
26MP0001970_abnormal_pain_threshold1.90339849
27MP0000778_abnormal_nervous_system1.89486432
28MP0002184_abnormal_innervation1.89324905
29MP0002909_abnormal_adrenal_gland1.83023027
30MP0002557_abnormal_social/conspecific_i1.75942975
31MP0004147_increased_porphyrin_level1.75033641
32MP0000751_myopathy1.72761210
33MP0001984_abnormal_olfaction1.72688892
34MP0004924_abnormal_behavior1.72147264
35MP0005386_behavior/neurological_phenoty1.72147264
36MP0002102_abnormal_ear_morphology1.71844016
37MP0006292_abnormal_olfactory_placode1.68193420
38MP0004811_abnormal_neuron_physiology1.67231574
39MP0008569_lethality_at_weaning1.66208816
40MP0004858_abnormal_nervous_system1.59024853
41MP0003122_maternal_imprinting1.58977601
42MP0005646_abnormal_pituitary_gland1.58802783
43MP0003787_abnormal_imprinting1.56767716
44MP0008789_abnormal_olfactory_epithelium1.54753116
45MP0003329_amyloid_beta_deposits1.53941257
46MP0000955_abnormal_spinal_cord1.50037216
47MP0003879_abnormal_hair_cell1.45563615
48MP0001529_abnormal_vocalization1.43386511
49MP0004145_abnormal_muscle_electrophysio1.41746016
50MP0002882_abnormal_neuron_morphology1.36634697
51MP0002066_abnormal_motor_capabilities/c1.35986616
52MP0003890_abnormal_embryonic-extraembry1.35884432
53MP0005645_abnormal_hypothalamus_physiol1.33582649
54MP0004215_abnormal_myocardial_fiber1.30650636
55MP0006072_abnormal_retinal_apoptosis1.30035295
56MP0003646_muscle_fatigue1.28871737
57MP0004885_abnormal_endolymph1.25680381
58MP0000749_muscle_degeneration1.23263128
59MP0001485_abnormal_pinna_reflex1.18989695
60MP0001188_hyperpigmentation1.15178973
61MP0005253_abnormal_eye_physiology1.15106420
62MP0000013_abnormal_adipose_tissue1.14358449
63MP0001502_abnormal_circadian_rhythm1.13620710
64MP0004142_abnormal_muscle_tone1.12105562
65MP0001905_abnormal_dopamine_level1.11531793
66MP0002234_abnormal_pharynx_morphology1.10688038
67MP0003633_abnormal_nervous_system1.10119187
68MP0002152_abnormal_brain_morphology1.07735910
69MP0004085_abnormal_heartbeat1.05586667
70MP0010386_abnormal_urinary_bladder1.04683690
71MP0004484_altered_response_of1.04099833
72MP0004233_abnormal_muscle_weight1.00377213
73MP0008058_abnormal_DNA_repair0.99635674
74MP0004133_heterotaxia0.99611172
75MP0003137_abnormal_impulse_conducting0.98762508
76MP0004036_abnormal_muscle_relaxation0.96361753
77MP0001293_anophthalmia0.94905872
78MP0003631_nervous_system_phenotype0.94083188
79MP0003718_maternal_effect0.90779442
80MP0000569_abnormal_digit_pigmentation0.90489949
81MP0003567_abnormal_fetal_cardiomyocyte0.88490027
82MP0006035_abnormal_mitochondrial_morpho0.87822091
83MP0002106_abnormal_muscle_physiology0.87140317
84MP0003136_yellow_coat_color0.86348270
85MP0002069_abnormal_eating/drinking_beha0.85616223
86MP0003119_abnormal_digestive_system0.85581996
87MP0002751_abnormal_autonomic_nervous0.83955917
88MP0002229_neurodegeneration0.83733412
89MP0000631_abnormal_neuroendocrine_gland0.82921738
90MP0001299_abnormal_eye_distance/0.82536866
91MP0004084_abnormal_cardiac_muscle0.81192028
92MP0005499_abnormal_olfactory_system0.80338202
93MP0005394_taste/olfaction_phenotype0.80338202
94MP0005248_abnormal_Harderian_gland0.80104509
95MP0005535_abnormal_body_temperature0.79973434
96MP0004742_abnormal_vestibular_system0.78598437
97MP0008961_abnormal_basal_metabolism0.78268616
98MP0001963_abnormal_hearing_physiology0.78142534
99MP0002752_abnormal_somatic_nervous0.76327764
100MP0005620_abnormal_muscle_contractility0.75843612
101MP0002876_abnormal_thyroid_physiology0.75345033
102MP0004130_abnormal_muscle_cell0.75099290
103MP0003221_abnormal_cardiomyocyte_apopto0.74199808
104MP0002233_abnormal_nose_morphology0.73719690
105MP0005551_abnormal_eye_electrophysiolog0.72965812
106MP0002938_white_spotting0.72850537
107MP0003283_abnormal_digestive_organ0.72247948
108MP0004043_abnormal_pH_regulation0.72121401
109MP0003385_abnormal_body_wall0.71781317
110MP0003937_abnormal_limbs/digits/tail_de0.71515663
111MP0003634_abnormal_glial_cell0.71455781
112MP0003698_abnormal_male_reproductive0.71399982
113MP0002638_abnormal_pupillary_reflex0.71053465
114MP0008872_abnormal_physiological_respon0.70600601
115MP0005187_abnormal_penis_morphology0.69424484
116MP0005623_abnormal_meninges_morphology0.69146125
117MP0001177_atelectasis0.68628940
118MP0008874_decreased_physiological_sensi0.67811415
119MP0003123_paternal_imprinting0.66513244
120MP0003121_genomic_imprinting0.66096655
121MP0002972_abnormal_cardiac_muscle0.64361501
122MP0000747_muscle_weakness0.63232555
123MP0003632_abnormal_nervous_system0.62485942
124MP0001943_abnormal_respiration0.60585984
125MP0003861_abnormal_nervous_system0.58971475
126MP0001664_abnormal_digestion0.58894877
127MP0004510_myositis0.57334413
128MP0002090_abnormal_vision0.56812238

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.33249344
2Myokymia (HP:0002411)5.80953426
3Focal seizures (HP:0007359)5.24934993
4Visual hallucinations (HP:0002367)5.04548313
5Atonic seizures (HP:0010819)4.67301358
6Epileptic encephalopathy (HP:0200134)4.56901008
7Febrile seizures (HP:0002373)4.21483015
8Absence seizures (HP:0002121)4.09371324
9Progressive cerebellar ataxia (HP:0002073)4.01856943
10Generalized tonic-clonic seizures (HP:0002069)3.68765794
11Dialeptic seizures (HP:0011146)3.65868872
12Exercise-induced muscle cramps (HP:0003710)3.55633249
13Broad-based gait (HP:0002136)3.42025072
14Action tremor (HP:0002345)3.35427874
15Hyperventilation (HP:0002883)3.33930430
16Poor eye contact (HP:0000817)3.19040547
17Supranuclear gaze palsy (HP:0000605)3.02149935
18Progressive inability to walk (HP:0002505)2.96951647
19Pheochromocytoma (HP:0002666)2.95026997
20Ankle clonus (HP:0011448)2.94118638
21Amblyopia (HP:0000646)2.92074560
22Impaired vibration sensation in the lower limbs (HP:0002166)2.90831540
23Impaired social interactions (HP:0000735)2.87798583
24Abnormal social behavior (HP:0012433)2.87798583
25Dysdiadochokinesis (HP:0002075)2.86824500
26Depression (HP:0000716)2.86677962
27Anxiety (HP:0000739)2.80913785
28Rimmed vacuoles (HP:0003805)2.80713477
29Gaze-evoked nystagmus (HP:0000640)2.79689419
30Medial flaring of the eyebrow (HP:0010747)2.78793636
31Truncal ataxia (HP:0002078)2.74547881
32Abnormal eating behavior (HP:0100738)2.72215086
33Insidious onset (HP:0003587)2.71988181
34Termporal pattern (HP:0011008)2.71988181
35Excessive salivation (HP:0003781)2.70149097
36Drooling (HP:0002307)2.70149097
37Neuroendocrine neoplasm (HP:0100634)2.69748263
38Papilledema (HP:0001085)2.66957549
39Mutism (HP:0002300)2.65873625
40Urinary bladder sphincter dysfunction (HP:0002839)2.65624051
41Abnormality of the labia minora (HP:0012880)2.63747443
42Calf muscle hypertrophy (HP:0008981)2.63613318
43Muscle hypertrophy of the lower extremities (HP:0008968)2.62978544
44Muscle fiber inclusion bodies (HP:0100299)2.58453236
45Bundle branch block (HP:0011710)2.58188808
46Congenital primary aphakia (HP:0007707)2.57022358
47Nemaline bodies (HP:0003798)2.54937954
48Genetic anticipation (HP:0003743)2.54561259
49Limb dystonia (HP:0002451)2.54003745
50Genital tract atresia (HP:0001827)2.46975848
51Epileptiform EEG discharges (HP:0011182)2.45927088
52Urinary urgency (HP:0000012)2.43511345
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.43489991
54Dysmetria (HP:0001310)2.42946069
55Fetal akinesia sequence (HP:0001989)2.41283220
56Vaginal atresia (HP:0000148)2.40637906
57Colon cancer (HP:0003003)2.37580937
58EEG with generalized epileptiform discharges (HP:0011198)2.35655732
59Inability to walk (HP:0002540)2.33658209
60Postural instability (HP:0002172)2.33302493
61Agitation (HP:0000713)2.33246421
62Absent speech (HP:0001344)2.30159075
63Polyphagia (HP:0002591)2.29064704
64Nephrogenic diabetes insipidus (HP:0009806)2.28651792
65Ventricular fibrillation (HP:0001663)2.26619441
66Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.24295663
67Degeneration of the lateral corticospinal tracts (HP:0002314)2.24295663
68Hypsarrhythmia (HP:0002521)2.23070550
69Neoplasm of the peripheral nervous system (HP:0100007)2.22646350
70Hyperglycinemia (HP:0002154)2.17779410
71Impaired smooth pursuit (HP:0007772)2.16727217
72Nephronophthisis (HP:0000090)2.14861826
73Type II lissencephaly (HP:0007260)2.13306652
74Lissencephaly (HP:0001339)2.13084314
75Hemiparesis (HP:0001269)2.11934213
76Torticollis (HP:0000473)2.11703036
77Dysmetric saccades (HP:0000641)2.11165112
78Scanning speech (HP:0002168)2.10877787
79Sudden death (HP:0001699)2.09096210
80Bradykinesia (HP:0002067)2.07502901
81Abnormality of the corticospinal tract (HP:0002492)2.06534478
82Cerebral inclusion bodies (HP:0100314)2.05396779
83Spastic gait (HP:0002064)2.04350607
84Megalencephaly (HP:0001355)2.03055625
85Oligodactyly (hands) (HP:0001180)2.01057479
86Gait imbalance (HP:0002141)2.01051340
87Papillary thyroid carcinoma (HP:0002895)1.99518061
88Abnormality of binocular vision (HP:0011514)1.99333186
89Diplopia (HP:0000651)1.99333186
90Aplasia/Hypoplasia of the brainstem (HP:0007362)1.98664844
91Hypoplasia of the brainstem (HP:0002365)1.98664844
92Focal dystonia (HP:0004373)1.98589374
93Optic nerve hypoplasia (HP:0000609)1.98128828
94Abnormality of the lower motor neuron (HP:0002366)1.97254503
95Pachygyria (HP:0001302)1.96978670
96Lower limb muscle weakness (HP:0007340)1.95930200
97Cortical dysplasia (HP:0002539)1.94996720
98Amyotrophic lateral sclerosis (HP:0007354)1.94797688
99Stereotypic behavior (HP:0000733)1.94387653
100Exercise-induced myalgia (HP:0003738)1.94005287
101Renal cortical cysts (HP:0000803)1.93895285
102Volvulus (HP:0002580)1.91744935
103Hypoventilation (HP:0002791)1.89823752
104Neurofibrillary tangles (HP:0002185)1.89770346
105Pancreatic fibrosis (HP:0100732)1.88979427
106Hyperglycinuria (HP:0003108)1.88303746
107Myotonia (HP:0002486)1.87489452
108Hyperthyroidism (HP:0000836)1.86539570
109Intention tremor (HP:0002080)1.86455587
110Chronic hepatic failure (HP:0100626)1.85963339
111Prolonged QT interval (HP:0001657)1.85710897
112Poor coordination (HP:0002370)1.85641692
113Failure to thrive in infancy (HP:0001531)1.85582965
114Generalized myoclonic seizures (HP:0002123)1.85281321
115Abnormal EKG (HP:0003115)1.85207421
116Intestinal atresia (HP:0011100)1.84993664
117Pancreatic cysts (HP:0001737)1.84934943
118Impaired vibratory sensation (HP:0002495)1.84518790
119Syncope (HP:0001279)1.83838438
120Inappropriate behavior (HP:0000719)1.82749938
121Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82226774
122Blue irides (HP:0000635)1.81792918
123Protruding tongue (HP:0010808)1.81565207
124Abnormality of the renal medulla (HP:0100957)1.80553875
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79901214
126Abnormality of ocular smooth pursuit (HP:0000617)1.79215560
127Cerebral hypomyelination (HP:0006808)1.79206422
128Obstructive sleep apnea (HP:0002870)1.79158451
129True hermaphroditism (HP:0010459)1.78656717
130Specific learning disability (HP:0001328)1.78254553
131Retinal dysplasia (HP:0007973)1.78050616
132Lower limb amyotrophy (HP:0007210)1.77402842
133Shoulder girdle muscle weakness (HP:0003547)1.77268121
134Left ventricular hypertrophy (HP:0001712)1.77126330
135Abnormality of salivation (HP:0100755)1.75234889
136Abnormality of midbrain morphology (HP:0002418)1.74494364
137Molar tooth sign on MRI (HP:0002419)1.74494364
138Craniofacial dystonia (HP:0012179)1.73957220
139Aplasia/Hypoplasia of the tibia (HP:0005772)1.73640970
140Abnormality of alanine metabolism (HP:0010916)1.72874585
141Hyperalaninemia (HP:0003348)1.72874585
142Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72874585
143Abnormality of the renal cortex (HP:0011035)1.72771447
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72751966
145Abnormality of the calf musculature (HP:0001430)1.72106782
146Abnormality of glycine metabolism (HP:0010895)1.70235595
147Abnormality of serine family amino acid metabolism (HP:0010894)1.70235595
148Dyskinesia (HP:0100660)1.69641881
149Acute encephalopathy (HP:0006846)1.67346690
150Hepatoblastoma (HP:0002884)1.67219881
151Broad foot (HP:0001769)1.67117475
152Morphological abnormality of the pyramidal tract (HP:0002062)1.66342262
153Methylmalonic acidemia (HP:0002912)1.66298545
154Poor suck (HP:0002033)1.66267253
155Spastic tetraplegia (HP:0002510)1.66024007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.17132801
2MAP3K93.78363640
3MARK13.74863897
4MAP3K43.35823106
5EPHA43.33927111
6MAP2K72.76822476
7OBSCN2.69900306
8CASK2.65961140
9MINK12.63580188
10MAP3K122.56063679
11TRIM282.45828767
12DAPK22.34551053
13MAP2K42.19441282
14MAP4K21.95413079
15PAK61.94454307
16NTRK21.90710200
17KSR21.88371547
18PHKG11.76124782
19PHKG21.76124782
20PLK21.67714659
21KSR11.63070897
22MAPK131.59776096
23PRKD31.56903971
24NTRK11.54352519
25STK38L1.52324724
26CAMKK11.48540670
27DYRK21.47833814
28PNCK1.46128967
29DAPK11.45948379
30CDK51.40732074
31RIPK41.34993108
32GRK51.32651385
33BMPR1B1.30826263
34LATS21.30746147
35CDK191.22196837
36CSNK1G31.22184598
37MKNK21.17759587
38ARAF1.16571572
39STK391.16356365
40MAP3K21.14981471
41PRKCG1.12950003
42SIK21.12814086
43PRPF4B1.12616556
44CSNK1G11.12563450
45CSNK1A1L1.11995734
46NUAK11.09092588
47TNIK1.07628528
48STK381.07101248
49UHMK11.06919319
50MKNK11.06356314
51CAMK2A1.05179501
52ACVR1B1.03317009
53DYRK31.02412727
54ZAK1.00363383
55CAMKK20.96791412
56PLK30.96262994
57LMTK20.96192234
58PAK30.91394769
59NME10.90508191
60EPHA30.89690826
61RET0.89584742
62SGK2230.87437424
63SGK4940.87437424
64PLK40.86308592
65SRPK10.85880742
66TYRO30.84322400
67FES0.81849942
68STK110.81684093
69WNK30.81203942
70CDK140.81193172
71SGK20.80439882
72CDK180.79460082
73VRK10.76407645
74CAMK2B0.75872328
75CDK150.75571702
76BCKDK0.75304915
77CSNK1G20.74547915
78EIF2AK30.73217361
79CAMK10.73115578
80WNK40.72593820
81CCNB10.72208121
82TAOK10.71612752
83SGK10.67901061
84DYRK1A0.67280703
85ERBB30.66987085
86PKN10.66758549
87PINK10.66456652
88PRKCH0.65847346
89CDK11A0.64637654
90PTK2B0.64434465
91MAP3K130.63858010
92MUSK0.63856405
93PRKCE0.63057936
94OXSR10.62569588
95FER0.60985379
96NEK10.60165641
97LIMK10.60026572
98MST40.59516436
99RAF10.59209895
100AKT30.57844432
101PDK40.57605454
102PDK30.57605454
103CDK30.57337208
104MAP3K10.57335862
105INSRR0.56691894
106BMPR20.56236096
107SGK30.56164847
108CAMK2D0.54150825
109CDC70.54026007
110GRK10.53996049
111NEK20.53158237
112MARK20.52817895
113CAMK1G0.50887358
114GRK70.50405273
115PIK3CG0.50126271
116RPS6KA40.48807661
117RIPK10.48525797
118MAP3K60.48348788
119CAMK40.47903817
120PRKCZ0.47448958
121MAP2K10.46211445
122BRD40.46080500
123CSNK1D0.45162914
124PRKG10.43903009
125RPS6KA30.43480334
126PDK10.43391671
127FRK0.43384857
128WNK10.42389027
129SCYL20.42345976
130BCR0.42123737
131DMPK0.42071231
132YES10.41908369
133PDPK10.41539269
134PRKACA0.41327113
135CAMK2G0.41115571
136PLK10.40648595
137ADRBK20.40483263
138ALK0.40057837
139CSNK1E0.40031405
140MAPK100.39953018
141CDC42BPA0.39625747
142FGFR20.39495360
143PRKACB0.39239056
144MAPK120.39163918
145RPS6KA20.37983572
146CSNK1A10.36864901
147PIK3CA0.36563012
148TSSK60.36042321

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.51533212
2Synaptic vesicle cycle_Homo sapiens_hsa047213.12829094
3Olfactory transduction_Homo sapiens_hsa047402.72045961
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60077127
5GABAergic synapse_Homo sapiens_hsa047272.55688978
6Long-term potentiation_Homo sapiens_hsa047202.53747823
7Circadian entrainment_Homo sapiens_hsa047132.53695738
8Glutamatergic synapse_Homo sapiens_hsa047242.36690219
9Amphetamine addiction_Homo sapiens_hsa050312.33975229
10Morphine addiction_Homo sapiens_hsa050322.32088032
11Dopaminergic synapse_Homo sapiens_hsa047282.16123587
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11321837
13Insulin secretion_Homo sapiens_hsa049112.03736080
14Propanoate metabolism_Homo sapiens_hsa006401.99229343
15Salivary secretion_Homo sapiens_hsa049701.95180083
16Cholinergic synapse_Homo sapiens_hsa047251.87099479
17Taste transduction_Homo sapiens_hsa047421.82755073
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81896267
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.78430820
20Gastric acid secretion_Homo sapiens_hsa049711.77069191
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.74509786
22Renin secretion_Homo sapiens_hsa049241.70876820
23Oxytocin signaling pathway_Homo sapiens_hsa049211.68868306
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64296357
25Serotonergic synapse_Homo sapiens_hsa047261.64031423
26Long-term depression_Homo sapiens_hsa047301.62957602
27Protein export_Homo sapiens_hsa030601.61222687
28Collecting duct acid secretion_Homo sapiens_hsa049661.56466984
29Cocaine addiction_Homo sapiens_hsa050301.56216377
30Calcium signaling pathway_Homo sapiens_hsa040201.54365877
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51348571
32GnRH signaling pathway_Homo sapiens_hsa049121.45788169
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45777620
34Cardiac muscle contraction_Homo sapiens_hsa042601.43251372
35Gap junction_Homo sapiens_hsa045401.38323915
36Steroid biosynthesis_Homo sapiens_hsa001001.35852419
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27817310
38Type II diabetes mellitus_Homo sapiens_hsa049301.27546570
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23871182
40cAMP signaling pathway_Homo sapiens_hsa040241.22067378
41Estrogen signaling pathway_Homo sapiens_hsa049151.18106156
42Glioma_Homo sapiens_hsa052141.16630745
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.14131894
44Vibrio cholerae infection_Homo sapiens_hsa051101.12145320
45Axon guidance_Homo sapiens_hsa043601.10854873
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10306881
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07337409
48ErbB signaling pathway_Homo sapiens_hsa040121.05680296
49Fatty acid elongation_Homo sapiens_hsa000621.05195161
50Dilated cardiomyopathy_Homo sapiens_hsa054141.05018222
51Melanogenesis_Homo sapiens_hsa049161.03173969
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02873302
53Basal transcription factors_Homo sapiens_hsa030220.98124182
54Regulation of autophagy_Homo sapiens_hsa041400.98003966
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94966359
56Fatty acid metabolism_Homo sapiens_hsa012120.94435511
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92966679
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91937322
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.91872650
60Oocyte meiosis_Homo sapiens_hsa041140.91052879
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88743266
62RNA degradation_Homo sapiens_hsa030180.88711652
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88422842
64Pyruvate metabolism_Homo sapiens_hsa006200.85935443
65beta-Alanine metabolism_Homo sapiens_hsa004100.85895101
66Dorso-ventral axis formation_Homo sapiens_hsa043200.85716014
67Fanconi anemia pathway_Homo sapiens_hsa034600.85576755
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84927019
69Selenocompound metabolism_Homo sapiens_hsa004500.84816052
70Alzheimers disease_Homo sapiens_hsa050100.84709419
71Nitrogen metabolism_Homo sapiens_hsa009100.83350580
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82513724
73Peroxisome_Homo sapiens_hsa041460.79842819
74Oxidative phosphorylation_Homo sapiens_hsa001900.79255968
75Pancreatic secretion_Homo sapiens_hsa049720.78448963
76Phototransduction_Homo sapiens_hsa047440.78195728
77Arginine and proline metabolism_Homo sapiens_hsa003300.77006005
78Glucagon signaling pathway_Homo sapiens_hsa049220.76980269
79Non-homologous end-joining_Homo sapiens_hsa034500.76084745
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75882390
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73665011
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.73462716
83MAPK signaling pathway_Homo sapiens_hsa040100.72471200
84Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72021949
85Thyroid hormone synthesis_Homo sapiens_hsa049180.71536619
86Choline metabolism in cancer_Homo sapiens_hsa052310.71471642
87Parkinsons disease_Homo sapiens_hsa050120.70034496
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69888227
89Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68487203
90Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67542145
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66467767
92VEGF signaling pathway_Homo sapiens_hsa043700.65106393
93Tight junction_Homo sapiens_hsa045300.63700189
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.62847697
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62136413
96Ras signaling pathway_Homo sapiens_hsa040140.61439425
97mTOR signaling pathway_Homo sapiens_hsa041500.60462408
98Insulin signaling pathway_Homo sapiens_hsa049100.60242805
99Endometrial cancer_Homo sapiens_hsa052130.59965537
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59625044
101Fatty acid degradation_Homo sapiens_hsa000710.59419062
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59014884
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57312947
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57231954
105Hippo signaling pathway_Homo sapiens_hsa043900.57109394
106Tryptophan metabolism_Homo sapiens_hsa003800.56686695
107RNA transport_Homo sapiens_hsa030130.55755246
108Renal cell carcinoma_Homo sapiens_hsa052110.55215453
109Hedgehog signaling pathway_Homo sapiens_hsa043400.54545034
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54385553
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54159594
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53599057
113Circadian rhythm_Homo sapiens_hsa047100.53158136
114Mismatch repair_Homo sapiens_hsa034300.52190049
115Rap1 signaling pathway_Homo sapiens_hsa040150.51728612
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51078177
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50736428
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49198655
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.48239252
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.46787423
121Carbon metabolism_Homo sapiens_hsa012000.46184496
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45879862
123mRNA surveillance pathway_Homo sapiens_hsa030150.44780021
124Purine metabolism_Homo sapiens_hsa002300.44731561
125Wnt signaling pathway_Homo sapiens_hsa043100.44423669
126Type I diabetes mellitus_Homo sapiens_hsa049400.44310321
127Huntingtons disease_Homo sapiens_hsa050160.44258819
128Non-small cell lung cancer_Homo sapiens_hsa052230.44145251
129Inositol phosphate metabolism_Homo sapiens_hsa005620.43768093
130Alcoholism_Homo sapiens_hsa050340.42173370
131Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42057259
132Ovarian steroidogenesis_Homo sapiens_hsa049130.41277425
133Linoleic acid metabolism_Homo sapiens_hsa005910.40684410
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40470461
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.40316107
136RNA polymerase_Homo sapiens_hsa030200.40232159
137Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38187182
138Colorectal cancer_Homo sapiens_hsa052100.38071340
139Endocytosis_Homo sapiens_hsa041440.36834614
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35885709
141Melanoma_Homo sapiens_hsa052180.35243987
142Butanoate metabolism_Homo sapiens_hsa006500.31217075
143Prion diseases_Homo sapiens_hsa050200.31216996

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