STC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.56875219
2positive regulation of interleukin-8 secretion (GO:2000484)7.00145450
3hyaluronan catabolic process (GO:0030214)6.39995342
4positive regulation of urine volume (GO:0035810)5.79193289
5positive regulation of macrophage activation (GO:0043032)5.57125330
6cAMP biosynthetic process (GO:0006171)5.49904541
7SMAD protein complex assembly (GO:0007183)5.33922681
8vascular endothelial growth factor signaling pathway (GO:0038084)5.23254286
9regulation of interleukin-8 secretion (GO:2000482)5.16698297
10lymphangiogenesis (GO:0001946)5.14660161
11neuron projection extension involved in neuron projection guidance (GO:1902284)5.06977687
12axon extension involved in axon guidance (GO:0048846)5.06977687
13endothelium development (GO:0003158)4.92398541
14protein maturation by protein folding (GO:0022417)4.72271845
15positive regulation of chemokine secretion (GO:0090197)4.55207507
16regulation of integrin-mediated signaling pathway (GO:2001044)4.30717100
17negative regulation of protein tyrosine kinase activity (GO:0061099)4.29021123
18renal absorption (GO:0070293)4.20833982
19retina vasculature morphogenesis in camera-type eye (GO:0061299)4.16574438
20cell migration involved in sprouting angiogenesis (GO:0002042)4.12754593
21lung lobe morphogenesis (GO:0060463)4.10861785
22modulation by virus of host morphology or physiology (GO:0019048)4.07725300
23cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.06962056
24regulation of chemokine secretion (GO:0090196)4.06677722
25multicellular organismal aging (GO:0010259)4.06561637
26regulation of metalloenzyme activity (GO:0048552)4.03291779
27regulation of fibroblast migration (GO:0010762)4.01733238
28facial nerve structural organization (GO:0021612)4.00390182
29sprouting angiogenesis (GO:0002040)4.00178773
30vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.96982220
31negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.94761772
32glomerular filtration (GO:0003094)3.93127780
33regulation of urine volume (GO:0035809)3.89262686
34type B pancreatic cell proliferation (GO:0044342)3.76981296
35peptidyl-proline hydroxylation (GO:0019511)3.76421879
36metanephric mesenchyme development (GO:0072075)3.74783586
37* chondrocyte proliferation (GO:0035988)3.73683123
38renal filtration (GO:0097205)3.70007957
39wound healing, spreading of epidermal cells (GO:0035313)3.65316950
40positive regulation of respiratory burst (GO:0060267)3.64432728
41substrate-dependent cell migration (GO:0006929)3.62806690
42ganglion development (GO:0061548)3.55835020
43regulation of axon extension involved in axon guidance (GO:0048841)3.50724798
44viral entry into host cell (GO:0046718)3.49827618
45regulation of endothelial cell differentiation (GO:0045601)3.48767377
46anterior/posterior axis specification, embryo (GO:0008595)3.47859828
47negative regulation of axon extension involved in axon guidance (GO:0048843)3.44124155
48response to UV-B (GO:0010224)3.43162822
49cellular response to ATP (GO:0071318)3.42199859
50mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.41331084
51kidney mesenchyme development (GO:0072074)3.36821043
52signal peptide processing (GO:0006465)3.33284582
53endodermal cell differentiation (GO:0035987)3.26460950
54positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.25151711
55protein hydroxylation (GO:0018126)3.23567913
56smooth muscle tissue development (GO:0048745)3.23470468
57blood vessel endothelial cell migration (GO:0043534)3.20183721
58blood vessel maturation (GO:0001955)3.19238553
59positive regulation of p38MAPK cascade (GO:1900745)3.17625519
60collagen fibril organization (GO:0030199)3.16485694
61cell differentiation involved in metanephros development (GO:0072202)3.14069395
62angiogenesis involved in wound healing (GO:0060055)3.13691993
63artery development (GO:0060840)3.13619493
644-hydroxyproline metabolic process (GO:0019471)3.12523751
65mesenchymal-epithelial cell signaling (GO:0060638)3.12489059
66protein heterotrimerization (GO:0070208)3.12029368
67muscle organ morphogenesis (GO:0048644)3.11717464
68regulation of axon guidance (GO:1902667)3.10718380
69cell migration involved in heart development (GO:0060973)3.09887109
70positive regulation of astrocyte differentiation (GO:0048711)3.08447611
71negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.07060216
72positive regulation of vasculogenesis (GO:2001214)3.05222767
73mesenchymal cell differentiation involved in kidney development (GO:0072161)3.03740779
74mesenchymal cell differentiation involved in renal system development (GO:2001012)3.03740779
75heparin metabolic process (GO:0030202)3.03657006
76heparin biosynthetic process (GO:0030210)3.03657006
77glomerulus development (GO:0032835)3.03512314
78patterning of blood vessels (GO:0001569)3.03215835
79L-ascorbic acid metabolic process (GO:0019852)3.03189397
80COPII vesicle coating (GO:0048208)3.01422546
81glomerular basement membrane development (GO:0032836)3.00329107
82regulation of macrophage activation (GO:0043030)3.00217993
83sequestering of extracellular ligand from receptor (GO:0035581)2.99324022
84regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.96155933
85protein heterotetramerization (GO:0051290)2.96106454
86hippo signaling (GO:0035329)2.94882407
87cell proliferation involved in kidney development (GO:0072111)2.94767550
88* endothelial cell morphogenesis (GO:0001886)2.93975991
89ovulation from ovarian follicle (GO:0001542)2.92950647
90endocrine hormone secretion (GO:0060986)2.92734363
91cranial nerve structural organization (GO:0021604)2.92295525
92endothelial cell chemotaxis (GO:0035767)2.91852843
93positive regulation of osteoblast proliferation (GO:0033690)2.91279367
94regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.90201791
95hyaluronan metabolic process (GO:0030212)2.90014645
96peptidyl-tyrosine autophosphorylation (GO:0038083)2.89564084
97fibrinolysis (GO:0042730)2.88896670
98cyclic purine nucleotide metabolic process (GO:0052652)2.88883146
99nephron epithelium development (GO:0072009)2.88497786
100regulation of immunoglobulin secretion (GO:0051023)2.88309647
101Notch signaling involved in heart development (GO:0061314)2.88255582
102positive regulation of cardiac muscle cell differentiation (GO:2000727)2.87854716
103regulation of interleukin-13 production (GO:0032656)2.87201811
104chemokine-mediated signaling pathway (GO:0070098)2.86147851
105hypotonic response (GO:0006971)2.86046964
106venous blood vessel morphogenesis (GO:0048845)2.85638202
107negative regulation of axon guidance (GO:1902668)2.83496171
108regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.82172324
109vasculature development (GO:0001944)2.82006292
110negative regulation of keratinocyte proliferation (GO:0010839)2.81566002
111exocrine pancreas development (GO:0031017)2.80256207
112substrate adhesion-dependent cell spreading (GO:0034446)2.79923673
113basement membrane organization (GO:0071711)2.78665582
114dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.78647708
115mesenchyme morphogenesis (GO:0072132)2.77842090
116cell proliferation involved in metanephros development (GO:0072203)2.77287658
117endothelial cell differentiation (GO:0045446)2.75870356
118cardiac epithelial to mesenchymal transition (GO:0060317)2.75273124
119surfactant homeostasis (GO:0043129)2.74829188
120regulation of vasculogenesis (GO:2001212)2.74723422
121metanephric epithelium development (GO:0072207)2.74618618
122positive regulation of receptor recycling (GO:0001921)2.73458068
123cyclic nucleotide biosynthetic process (GO:0009190)2.72989798
124negative regulation of catenin import into nucleus (GO:0035414)2.72575155
125UDP-N-acetylglucosamine metabolic process (GO:0006047)2.72544400
126endocardial cushion morphogenesis (GO:0003203)2.72258009
127negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.71923975
128anatomical structure arrangement (GO:0048532)2.70890335
129metanephric nephron epithelium development (GO:0072243)2.69882812
130vasculogenesis (GO:0001570)2.68975309
131angiogenesis (GO:0001525)2.67988366
132positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.67696594
133morphogenesis of an endothelium (GO:0003159)2.67661308
134endothelial tube morphogenesis (GO:0061154)2.67661308
135regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67427179
136negative regulation of protein kinase B signaling (GO:0051898)2.67419189
137regulation of blood vessel endothelial cell migration (GO:0043535)2.67282310
138cAMP metabolic process (GO:0046058)2.66862902
139lung vasculature development (GO:0060426)2.66490182
140neural crest cell development (GO:0014032)2.65577757
141metanephric nephron tubule development (GO:0072234)2.63408893
142metanephric tubule development (GO:0072170)2.63408893
143epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.63219471
144modification by symbiont of host morphology or physiology (GO:0044003)2.62365038
145regulation of chemokine production (GO:0032642)2.61266367
146peptidyl-histidine modification (GO:0018202)2.59859747
147positive regulation of actin cytoskeleton reorganization (GO:2000251)2.59513990
148male sex determination (GO:0030238)2.58594199
149heart valve morphogenesis (GO:0003179)2.57756281
150mesenchymal cell development (GO:0014031)2.57421551
151regulation of transmission of nerve impulse (GO:0051969)2.56805370
152blood vessel remodeling (GO:0001974)2.55193323
153movement in host environment (GO:0052126)2.55116777
154entry into host cell (GO:0030260)2.55116777
155movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.55116777
156entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.55116777
157entry into host (GO:0044409)2.55116777
158entry into other organism involved in symbiotic interaction (GO:0051828)2.55116777
159Golgi transport vesicle coating (GO:0048200)2.54829282
160COPI coating of Golgi vesicle (GO:0048205)2.54829282
161G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.53997890
162outer ear morphogenesis (GO:0042473)2.52570064
163positive regulation of epithelial to mesenchymal transition (GO:0010718)2.52020166
164protein localization to cell surface (GO:0034394)2.51993844
165negative regulation of blood vessel endothelial cell migration (GO:0043537)2.51863647
166negative chemotaxis (GO:0050919)2.50387442
167respiratory tube development (GO:0030323)2.49835817
168regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.49710040
169epithelial to mesenchymal transition (GO:0001837)2.49405245
170mesodermal cell differentiation (GO:0048333)2.48880565
171axon extension (GO:0048675)2.48312642
172cell adhesion mediated by integrin (GO:0033627)2.47962768
173blood vessel morphogenesis (GO:0048514)2.46540662
174heart trabecula formation (GO:0060347)2.45620863
175endothelial cell proliferation (GO:0001935)2.42869567
176regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.42540304
177endothelial cell migration (GO:0043542)2.42107457
178regulation of positive chemotaxis (GO:0050926)2.39656840
179cell surface receptor signaling pathway involved in heart development (GO:0061311)2.39535213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.47988262
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.92204313
3SMAD_19615063_ChIP-ChIP_OVARY_Human2.99780240
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.83301350
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.74971473
6WT1_19549856_ChIP-ChIP_CCG9911_Human2.57346444
7ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse2.54116852
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.51176706
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.50585991
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33881202
11* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.22793780
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18653435
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18653435
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16035599
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.15938391
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.14715647
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.13043275
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11925326
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09708324
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09225378
21TP53_18474530_ChIP-ChIP_U2OS_Human2.05058197
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04771667
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04771667
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04771667
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.03770667
26ZNF217_24962896_ChIP-Seq_MCF-7_Human2.01612227
27JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.00980270
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99635871
29GBX2_23144817_ChIP-Seq_PC3_Human1.93135890
30JARID2_20064375_ChIP-Seq_MESCs_Mouse1.88114502
31CJUN_26792858_Chip-Seq_BT549_Human1.87662377
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.85100852
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.84380549
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.84082384
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82506485
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82267735
37JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80208915
38CLOCK_20551151_ChIP-Seq_293T_Human1.79881844
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79204911
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76952335
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76675256
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73835404
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70386614
44AR_21572438_ChIP-Seq_LNCaP_Human1.69337094
45* GATA2_21666600_ChIP-Seq_HMVEC_Human1.68476028
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.66807843
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62532194
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.60889504
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.60889504
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60778988
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59555579
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49511094
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.48989235
54BRD4_25478319_ChIP-Seq_HGPS_Human1.47807749
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47163812
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47124721
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.45184532
58VDR_22108803_ChIP-Seq_LS180_Human1.45161827
59ELK1_19687146_ChIP-ChIP_HELA_Human1.43273088
60TP53_16413492_ChIP-PET_HCT116_Human1.39429316
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38168287
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.35573553
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.35573553
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.35307185
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.33857038
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.33433483
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.32561070
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32286242
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31271231
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.30281777
71KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30111354
72SOX2_20726797_ChIP-Seq_SW620_Human1.29318619
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.28332289
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.28077472
75AHR_22903824_ChIP-Seq_MCF-7_Human1.27912977
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.27638844
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.26448130
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26007799
79TBX20_22328084_ChIP-Seq_HEART_Mouse1.25816316
80TBX20_22080862_ChIP-Seq_HEART_Mouse1.25816316
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25039516
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.24485133
83TP63_23658742_ChIP-Seq_EP156T_Human1.23028628
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.22506030
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.22460751
86ISL1_27105846_Chip-Seq_CPCs_Mouse1.21956684
87SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21546537
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20362380
89ARNT_22903824_ChIP-Seq_MCF-7_Human1.20060195
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18617749
91* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18178704
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17451132
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16871745
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.15890189
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15633398
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14774354
97RXR_22108803_ChIP-Seq_LS180_Human1.14741215
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13271615
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12765867
100PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11649681
101* P300_19829295_ChIP-Seq_ESCs_Human1.10434660
102SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10284847
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10236257
104PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09607908
105GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09189354
106CDX2_20551321_ChIP-Seq_CACO-2_Human1.08820531
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.08136874
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06538999
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06369613
110VDR_24787735_ChIP-Seq_THP-1_Human1.06327930
111* SMAD3_21741376_ChIP-Seq_EPCs_Human1.05874755
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05609065
113WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04541030
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03214060
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02546749
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02125218
117PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01734914
118NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01709236
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00041601
120EOMES_21245162_ChIP-Seq_HESCs_Human0.99545664
121TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99164259
122SMAD3_21741376_ChIP-Seq_HESCs_Human0.98783504
123UBF1/2_26484160_Chip-Seq_HMECs_Human0.97749705
124BCAT_22108803_ChIP-Seq_LS180_Human0.97553260
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.96910099
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96688096
127PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.96616479
128FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96599337
129TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95590780
130RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95441198
131TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94971876
132ESR2_21235772_ChIP-Seq_MCF-7_Human0.93140593
133EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93106309
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92105456
135SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.90812067
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90761405
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90375962
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89876590
139PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88858599
140PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.88545337
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88164449
142EZH2_27294783_Chip-Seq_NPCs_Mouse0.86537282
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85144314
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84500253
145RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83930792
146NANOG_16518401_ChIP-PET_MESCs_Mouse0.82974715
147JUN_21703547_ChIP-Seq_K562_Human0.81026096

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.56989882
2MP0001879_abnormal_lymphatic_vessel4.86998182
3MP0004272_abnormal_basement_membrane3.94210656
4MP0008438_abnormal_cutaneous_collagen3.94097159
5MP0005503_abnormal_tendon_morphology3.38110180
6MP0005084_abnormal_gallbladder_morpholo2.88956085
7MP0003724_increased_susceptibility_to2.86921679
8MP0005623_abnormal_meninges_morphology2.69292668
9MP0009379_abnormal_foot_pigmentation2.58829884
10MP0002254_reproductive_system_inflammat2.44588059
11MP0003828_pulmonary_edema2.32710819
12MP0003279_aneurysm2.31946397
13MP0005275_abnormal_skin_tensile2.28365370
14MP0006054_spinal_hemorrhage2.28274850
15MP0005367_renal/urinary_system_phenotyp2.17053889
16MP0000516_abnormal_urinary_system2.17053889
17MP0003941_abnormal_skin_development2.16898323
18MP0009250_abnormal_appendicular_skeleto2.15652648
19MP0004510_myositis2.13061608
20MP0003705_abnormal_hypodermis_morpholog2.06688006
21MP0000767_abnormal_smooth_muscle1.96861011
22MP0003890_abnormal_embryonic-extraembry1.96066503
23MP0002138_abnormal_hepatobiliary_system1.96000782
24MP0003385_abnormal_body_wall1.93520423
25MP0010030_abnormal_orbit_morphology1.91314178
26MP0000537_abnormal_urethra_morphology1.90094597
27MP0000569_abnormal_digit_pigmentation1.88130033
28MP0003950_abnormal_plasma_membrane1.85149467
29MP0009384_cardiac_valve_regurgitation1.81563022
30MP0009053_abnormal_anal_canal1.76172402
31MP0005508_abnormal_skeleton_morphology1.72433728
32MP0001958_emphysema1.69342591
33MP0003567_abnormal_fetal_cardiomyocyte1.68215947
34MP0000534_abnormal_ureter_morphology1.67534996
35MP0005167_abnormal_blood-brain_barrier1.66631028
36MP0003942_abnormal_urinary_system1.61128786
37MP0005257_abnormal_intraocular_pressure1.60959028
38MP0003221_abnormal_cardiomyocyte_apopto1.49271000
39MP0002896_abnormal_bone_mineralization1.48406493
40MP0009764_decreased_sensitivity_to1.45991670
41MP0000049_abnormal_middle_ear1.42613833
42MP0005171_absent_coat_pigmentation1.41908153
43MP0004484_altered_response_of1.38745326
44MP0005187_abnormal_penis_morphology1.35330061
45MP0009278_abnormal_bone_marrow1.34031925
46MP0000013_abnormal_adipose_tissue1.33913628
47MP0005248_abnormal_Harderian_gland1.32659526
48MP0002295_abnormal_pulmonary_circulatio1.32431518
49MP0005310_abnormal_salivary_gland1.29841000
50MP0003122_maternal_imprinting1.29365394
51MP0008004_abnormal_stomach_pH1.28139323
52MP0002877_abnormal_melanocyte_morpholog1.25242915
53MP0003283_abnormal_digestive_organ1.24707070
54MP0000566_synostosis1.24478881
55MP0003091_abnormal_cell_migration1.23595626
56MP0001188_hyperpigmentation1.22811759
57MP0003303_peritoneal_inflammation1.21137863
58MP0002282_abnormal_trachea_morphology1.20946523
59MP0003755_abnormal_palate_morphology1.20925692
60MP0003566_abnormal_cell_adhesion1.19548492
61MP0005595_abnormal_vascular_smooth1.18353072
62MP0002925_abnormal_cardiovascular_devel1.18231337
63MP0003315_abnormal_perineum_morphology1.14275349
64MP0006138_congestive_heart_failure1.11968771
65MP0003935_abnormal_craniofacial_develop1.08201408
66MP0001849_ear_inflammation1.07841581
67MP0002009_preneoplasia1.05000261
68MP0001614_abnormal_blood_vessel1.04721360
69MP0002128_abnormal_blood_circulation1.04665460
70MP0000762_abnormal_tongue_morphology1.03873038
71MP0002249_abnormal_larynx_morphology1.03786988
72MP0000163_abnormal_cartilage_morphology1.03598249
73MP0002060_abnormal_skin_morphology1.03081923
74MP0005365_abnormal_bile_salt1.02607656
75MP0003115_abnormal_respiratory_system1.01603208
76MP0002108_abnormal_muscle_morphology1.01381790
77MP0003806_abnormal_nucleotide_metabolis0.99681567
78MP0001299_abnormal_eye_distance/0.95711720
79MP0002115_abnormal_skeleton_extremities0.94567308
80MP0004883_abnormal_blood_vessel0.94108164
81MP0005390_skeleton_phenotype0.93862344
82MP0004084_abnormal_cardiac_muscle0.93351877
83MP0005164_abnormal_response_to0.93343249
84MP0002932_abnormal_joint_morphology0.92682117
85MP0002133_abnormal_respiratory_system0.90710439
86MP0005388_respiratory_system_phenotype0.90710439
87MP0002233_abnormal_nose_morphology0.89907014
88MP0000733_abnormal_muscle_development0.88587643
89MP0005165_increased_susceptibility_to0.88320059
90MP0002177_abnormal_outer_ear0.86831843
91MP0002163_abnormal_gland_morphology0.86510603
92MP0002113_abnormal_skeleton_development0.85339018
93MP0005360_urolithiasis0.83047545
94MP0002168_other_aberrant_phenotype0.82944661
95MP0002116_abnormal_craniofacial_bone0.82801124
96MP0002109_abnormal_limb_morphology0.82132621
97MP0005409_darkened_coat_color0.81937019
98MP0000003_abnormal_adipose_tissue0.80567976
99MP0003984_embryonic_growth_retardation0.80324445
100MP0002102_abnormal_ear_morphology0.80144854
101MP0001346_abnormal_lacrimal_gland0.79458328
102MP0002088_abnormal_embryonic_growth/wei0.78902021
103MP0005023_abnormal_wound_healing0.78607123
104MP0009780_abnormal_chondrocyte_physiolo0.78467904
105MP0003943_abnormal_hepatobiliary_system0.77884716
106MP0002933_joint_inflammation0.77793859
107MP0009840_abnormal_foam_cell0.77384008
108MP0010234_abnormal_vibrissa_follicle0.76649686
109MP0003937_abnormal_limbs/digits/tail_de0.75253198
110MP0000432_abnormal_head_morphology0.73802361
111MP0005499_abnormal_olfactory_system0.72883525
112MP0005394_taste/olfaction_phenotype0.72883525
113MP0005380_embryogenesis_phenotype0.72002964
114MP0001672_abnormal_embryogenesis/_devel0.72002964
115MP0005076_abnormal_cell_differentiation0.71532079
116MP0001270_distended_abdomen0.71315077
117MP0001851_eye_inflammation0.70630494
118MP0001784_abnormal_fluid_regulation0.70306838
119MP0004808_abnormal_hematopoietic_stem0.69694633
120MP0000343_altered_response_to0.68214088
121MP0003300_gastrointestinal_ulcer0.68066064
122MP0001915_intracranial_hemorrhage0.68002552
123MP0010352_gastrointestinal_tract_polyps0.67216507
124MP0000249_abnormal_blood_vessel0.67093138
125MP0000427_abnormal_hair_cycle0.66874999
126MP0000428_abnormal_craniofacial_morphol0.66298735
127MP0002089_abnormal_postnatal_growth/wei0.65947963
128MP0008260_abnormal_autophagy0.65013498
129MP0009697_abnormal_copulation0.64568458
130MP0008775_abnormal_heart_ventricle0.63763443
131MP0002086_abnormal_extraembryonic_tissu0.63516973
132MP0003045_fibrosis0.63359074
133MP0000358_abnormal_cell_content/0.62773749
134MP0000383_abnormal_hair_follicle0.62367238
135MP0000266_abnormal_heart_morphology0.61576854
136MP0004085_abnormal_heartbeat0.60815327
137MP0005410_abnormal_fertilization0.60225527
138MP0001542_abnormal_bone_strength0.59712377
139MP0000751_myopathy0.57923097
140MP0002084_abnormal_developmental_patter0.55628197
141MP0001348_abnormal_lacrimal_gland0.54411955
142MP0002972_abnormal_cardiac_muscle0.52767265
143MP0003186_abnormal_redox_activity0.50549770
144MP0005197_abnormal_uvea_morphology0.49983548
145MP0001243_abnormal_dermal_layer0.49913896
146MP0001853_heart_inflammation0.49643776
147MP0005670_abnormal_white_adipose0.49630837
148MP0002405_respiratory_system_inflammati0.46973709
149MP0010678_abnormal_skin_adnexa0.46242975
150MP0001544_abnormal_cardiovascular_syste0.45794515

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.62554285
2Abnormal gallbladder physiology (HP:0012438)5.62284550
3Cholecystitis (HP:0001082)5.62284550
4Premature rupture of membranes (HP:0001788)5.22428197
5Hypoglycemic seizures (HP:0002173)4.61132911
6Thick nail (HP:0001805)4.40812416
7Pigmentary retinal degeneration (HP:0001146)4.32015147
8Reduced subcutaneous adipose tissue (HP:0003758)4.17755360
9Hyperinsulinemic hypoglycemia (HP:0000825)3.64683553
10Aortic dissection (HP:0002647)3.60657083
11Pancreatic islet-cell hyperplasia (HP:0004510)3.60584330
12Long foot (HP:0001833)3.60480257
13Aortic aneurysm (HP:0004942)3.48799201
14Cerebral hemorrhage (HP:0001342)3.42448072
15Shallow orbits (HP:0000586)3.23325416
16Soft skin (HP:0000977)3.21701787
17Broad metatarsal (HP:0001783)3.06304850
18Follicular hyperkeratosis (HP:0007502)3.03905265
19Neonatal short-limb short stature (HP:0008921)3.00750115
20Nuclear cataract (HP:0100018)2.95862127
21Atrophic scars (HP:0001075)2.93328643
22Hypoglycemic coma (HP:0001325)2.93029681
23Hematochezia (HP:0002573)2.90528078
24Spinal rigidity (HP:0003306)2.85510243
25Abnormality of the intrinsic pathway (HP:0010989)2.82641168
26Overgrowth (HP:0001548)2.76252545
27Elfin facies (HP:0004428)2.72261374
28Cerebral aneurysm (HP:0004944)2.70641744
29Abnormality of the fetal cardiovascular system (HP:0010948)2.68140600
30Abnormal umbilical cord blood vessels (HP:0011403)2.68140600
31Single umbilical artery (HP:0001195)2.68140600
32Symptomatic seizures (HP:0011145)2.67555682
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66381273
34Short 4th metacarpal (HP:0010044)2.66381273
35Rectal prolapse (HP:0002035)2.65580402
36Cone-rod dystrophy (HP:0000548)2.62433643
37Aplasia involving bones of the upper limbs (HP:0009823)2.58266942
38Aplasia of the phalanges of the hand (HP:0009802)2.58266942
39Aplasia involving bones of the extremities (HP:0009825)2.58266942
40Subacute progressive viral hepatitis (HP:0006572)2.57178481
41Lymphangioma (HP:0100764)2.54295535
42Abnormality of dentin (HP:0010299)2.52975413
43Vascular tortuosity (HP:0004948)2.52703824
44Asymmetry of the thorax (HP:0001555)2.52462560
45Short hallux (HP:0010109)2.51605087
46Increased connective tissue (HP:0009025)2.47915004
47Concave nail (HP:0001598)2.42266935
48Spinal cord lesions (HP:0100561)2.41086580
49Syringomyelia (HP:0003396)2.41086580
50Type I transferrin isoform profile (HP:0003642)2.41038986
51Arterial tortuosity (HP:0005116)2.37056119
52Bladder diverticulum (HP:0000015)2.36366736
53Fragile skin (HP:0001030)2.35240878
54Dilatation of the ascending aorta (HP:0005111)2.34908313
55Wrist flexion contracture (HP:0001239)2.33868071
56Capillary hemangiomas (HP:0005306)2.31343482
57Slender build (HP:0001533)2.30805111
58Congenital, generalized hypertrichosis (HP:0004540)2.29202906
59Mesomelia (HP:0003027)2.28194014
60Venous abnormality (HP:0002624)2.27799767
61Atelectasis (HP:0100750)2.27660912
62Abnormal platelet function (HP:0011869)2.25420669
63Impaired platelet aggregation (HP:0003540)2.25420669
64Mitral valve prolapse (HP:0001634)2.23947982
65Insulin-resistant diabetes mellitus (HP:0000831)2.23578416
66Menorrhagia (HP:0000132)2.23058518
67Coronal craniosynostosis (HP:0004440)2.21139272
68Venous insufficiency (HP:0005293)2.19450420
69Ankle contracture (HP:0006466)2.18352264
70Genu recurvatum (HP:0002816)2.17808601
71Myocardial infarction (HP:0001658)2.17425204
72Aplasia/Hypoplasia of the hallux (HP:0008362)2.15358546
73Curly hair (HP:0002212)2.14406124
74Wormian bones (HP:0002645)2.13856751
75Adactyly (HP:0009776)2.13615522
76Tetraparesis (HP:0002273)2.13123579
77Wide anterior fontanel (HP:0000260)2.12373995
78Protruding ear (HP:0000411)2.10988594
79Bifid tongue (HP:0010297)2.10973246
80Hyperextensible skin (HP:0000974)2.08459608
81Growth hormone excess (HP:0000845)2.07095067
82Pulmonary artery stenosis (HP:0004415)2.06430540
83Acanthosis nigricans (HP:0000956)2.04299699
84Absent eyebrow (HP:0002223)2.02462689
85Abnormality of incisor morphology (HP:0011063)2.01746543
86Broad toe (HP:0001837)2.01153183
87Microglossia (HP:0000171)1.99399966
88Nonimmune hydrops fetalis (HP:0001790)1.98937243
89Methylmalonic aciduria (HP:0012120)1.98050205
90Short nail (HP:0001799)1.97614556
91Polycythemia (HP:0001901)1.97398972
92Down-sloping shoulders (HP:0200021)1.96564555
93Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.96260036
94Abnormal protein N-linked glycosylation (HP:0012347)1.95781822
95Abnormal protein glycosylation (HP:0012346)1.95781822
96Abnormal glycosylation (HP:0012345)1.95781822
97Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95781822
98Abnormality of the 2nd finger (HP:0004100)1.95581664
99Increased variability in muscle fiber diameter (HP:0003557)1.94744565
100Choroideremia (HP:0001139)1.94545422
101Joint laxity (HP:0001388)1.91753598
102Abnormality of the 4th metacarpal (HP:0010012)1.91752192
103Absent toe (HP:0010760)1.90585495
104Type 1 muscle fiber predominance (HP:0003803)1.90127668
105Bulbous nose (HP:0000414)1.90029571
106Hypophosphatemic rickets (HP:0004912)1.88964673
107Deviation of the hallux (HP:0010051)1.88693857
108Thoracolumbar scoliosis (HP:0002944)1.88226017
109Hand muscle atrophy (HP:0009130)1.88054210
110Preaxial foot polydactyly (HP:0001841)1.86973400
111Blue sclerae (HP:0000592)1.84921304
112Abnormality of the pancreatic islet cells (HP:0006476)1.84873532
113Abnormality of endocrine pancreas physiology (HP:0012093)1.84873532
114Thickened helices (HP:0000391)1.84582899
115Distal upper limb amyotrophy (HP:0007149)1.84392291
116Upper limb amyotrophy (HP:0009129)1.84392291
117Broad hallux (HP:0010055)1.84198097
118Increased number of teeth (HP:0011069)1.83431870
119Achilles tendon contracture (HP:0001771)1.83179311
120Abnormality of the nasal septum (HP:0000419)1.82914250
121Mildly elevated creatine phosphokinase (HP:0008180)1.82295210
122Large earlobe (HP:0009748)1.81540833
123Hydroureter (HP:0000072)1.81242035
124Porencephaly (HP:0002132)1.81188993
125Advanced eruption of teeth (HP:0006288)1.80918413
126Tubulointerstitial nephritis (HP:0001970)1.80573209
127Abnormality of the umbilical cord (HP:0010881)1.80026283
128Biliary tract neoplasm (HP:0100574)1.80014717
129Cervical subluxation (HP:0003308)1.79610437
130Glucose intolerance (HP:0000833)1.79494195
131Hypoplasia of the iris (HP:0007676)1.79094459
132Neoplasm of the peripheral nervous system (HP:0100007)1.78968285
133Limited hip movement (HP:0008800)1.78388853
134Keratoconus (HP:0000563)1.78328532
135Increased corneal curvature (HP:0100692)1.78328532
136Hallux valgus (HP:0001822)1.77732639
137Obstructive sleep apnea (HP:0002870)1.77327644
138Abnormality of skeletal muscle fiber size (HP:0012084)1.76731640
139Cutaneous finger syndactyly (HP:0010554)1.76125939
140Mitral regurgitation (HP:0001653)1.75976620
141Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75910244
142Knee flexion contracture (HP:0006380)1.74276124
143Abnormality of proline metabolism (HP:0010907)1.72931227
144Hydroxyprolinuria (HP:0003080)1.72931227
145Aneurysm (HP:0002617)1.72338481
146Hyperglycemia (HP:0003074)1.71714558
147Disproportionate tall stature (HP:0001519)1.71025741
148Absent hand (HP:0004050)1.70557470
149Osteopenia (HP:0000938)1.69598182
150Camptodactyly of toe (HP:0001836)1.68836960
151Esophageal varix (HP:0002040)1.67988406
152Enlarged penis (HP:0000040)1.67709325
153Peritonitis (HP:0002586)1.67236705
154Skull defect (HP:0001362)1.66243040
155Hip contracture (HP:0003273)1.66053128
156Buphthalmos (HP:0000557)1.65751736
157Spinal cord compression (HP:0002176)1.59704936
158Hypoventilation (HP:0002791)1.59586432
159Portal hypertension (HP:0001409)1.58064507
160Biconcave vertebral bodies (HP:0004586)1.57978165
161Inguinal hernia (HP:0000023)1.57076706
162Abnormality of the phalanges of the hallux (HP:0010057)1.56906651
163Broad ribs (HP:0000885)1.56395243
164Palpebral edema (HP:0100540)1.56276038
165Germ cell neoplasia (HP:0100728)1.55679778
166Vertebral compression fractures (HP:0002953)1.54913966
167Broad long bones (HP:0005622)1.54212478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR8.60457029
2TIE17.18983883
3KDR5.34539154
4EPHB24.27066591
5FRK3.18237362
6ACVR1B3.11934880
7TEC3.00054271
8TGFBR12.76356538
9TGFBR22.74230787
10FER2.66912932
11LATS12.58832043
12CASK2.45263191
13PDGFRA2.40409872
14IRAK32.28909525
15RIPK12.23776714
16PTK2B2.14351753
17EPHA32.08700958
18DDR22.07587370
19DMPK2.01424704
20STK391.89484467
21NUAK11.72518000
22TESK11.70744015
23NTRK11.64556618
24ERBB31.64176169
25ITK1.51967574
26LATS21.46406049
27TAF11.45341425
28PIK3CG1.40708572
29EPHA41.28632454
30MKNK21.20858919
31EPHB11.19907000
32PLK21.19867583
33EIF2AK11.18939397
34RPS6KA41.12478865
35OXSR11.11829173
36PIM21.09793533
37EIF2AK31.08591361
38MYLK1.07887782
39PTK21.07242655
40FGFR31.07024025
41TNIK1.06407811
42MET1.05631776
43BMPR1B1.03167089
44PDK21.01846466
45MARK11.01036033
46BCR0.98227910
47PAK20.97069796
48PDGFRB0.95933860
49MKNK10.93808743
50ABL20.92711891
51PAK30.91344595
52CDK80.83092922
53PKN20.82414252
54PRPF4B0.81564282
55NEK90.79992148
56FGFR10.79928420
57NLK0.76747019
58PTK60.76739026
59PIK3CA0.76725575
60ADRBK20.75595191
61NEK60.75304644
62AKT30.73851004
63ADRBK10.72474593
64MOS0.71213958
65IGF1R0.70677318
66TBK10.70324697
67CDK60.69924823
68BTK0.69668426
69STK30.69562010
70ROCK10.69256375
71ZAP700.69036599
72CDK90.68360567
73PAK40.68148155
74MAP3K30.64342674
75STK38L0.63563711
76INSR0.63522589
77MAPKAPK30.62978985
78EPHA20.62772265
79LRRK20.62079051
80MAPK120.60759429
81CSNK1A1L0.59882177
82FES0.58400256
83PRKCE0.57766039
84ERN10.57465498
85TTN0.56991521
86PNCK0.56038089
87PRKG20.54847115
88PRKCH0.54197726
89STK100.52559048
90EIF2AK20.50787082
91MELK0.49412502
92PRKD30.48395685
93PBK0.47423917
94LMTK20.44599912
95ILK0.43989086
96NME20.43883902
97GSK3A0.43317786
98MAP4K20.42974481
99SRC0.42459978
100YES10.42295814
101DYRK20.41946810
102ROCK20.41202505
103CSK0.41085950
104GRK10.40744597
105STK160.39844260
106EGFR0.38552970
107PRKD10.37856278
108ERBB40.37607916
109MAPK70.37450552
110PRKD20.35755829
111NEK10.32921253
112BMX0.32890368
113GRK50.32063569
114JAK30.31836017
115MAP2K10.30853209
116BUB10.30750636
117ERBB20.29664367
118FLT30.29052294
119FGFR20.28275729
120DYRK1B0.28156055
121TRIB30.27714002
122CSNK1G20.27642511
123MAPK130.27595299
124CHUK0.26645154
125FGR0.26417204
126CLK10.25629571
127ABL10.24869840
128LIMK10.24353272
129PLK30.23890044
130MST1R0.23324133
131TRPM70.22972834
132ZAK0.22890675
133TSSK60.21591720
134AKT20.21311746
135SGK20.20953166
136CSNK1G10.20457960
137BRSK20.18916137
138ARAF0.17177383
139CAMK1G0.16297486
140MAPK100.16080034

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.20836933
2ECM-receptor interaction_Homo sapiens_hsa045122.63658794
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.45629453
4Complement and coagulation cascades_Homo sapiens_hsa046102.41989627
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.32450486
6Focal adhesion_Homo sapiens_hsa045102.30937168
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.26362634
8Adherens junction_Homo sapiens_hsa045202.20251560
9Proteasome_Homo sapiens_hsa030501.96515054
10Axon guidance_Homo sapiens_hsa043601.95088683
11Proteoglycans in cancer_Homo sapiens_hsa052051.87782519
12Malaria_Homo sapiens_hsa051441.85164003
13TGF-beta signaling pathway_Homo sapiens_hsa043501.85111397
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.85059242
15Basal cell carcinoma_Homo sapiens_hsa052171.83073767
16N-Glycan biosynthesis_Homo sapiens_hsa005101.79563380
17Ovarian steroidogenesis_Homo sapiens_hsa049131.62889749
18Hippo signaling pathway_Homo sapiens_hsa043901.62614994
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.61419073
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.56154364
21Rap1 signaling pathway_Homo sapiens_hsa040151.54623764
22MicroRNAs in cancer_Homo sapiens_hsa052061.48092591
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46313339
24Melanogenesis_Homo sapiens_hsa049161.43015578
25Dilated cardiomyopathy_Homo sapiens_hsa054141.42972142
26Leukocyte transendothelial migration_Homo sapiens_hsa046701.39269435
27Vibrio cholerae infection_Homo sapiens_hsa051101.39001489
28Melanoma_Homo sapiens_hsa052181.37428625
29Small cell lung cancer_Homo sapiens_hsa052221.36026846
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.35299956
31Protein digestion and absorption_Homo sapiens_hsa049741.32993455
32Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32985418
33Prostate cancer_Homo sapiens_hsa052151.31898604
34Bladder cancer_Homo sapiens_hsa052191.31355461
35Wnt signaling pathway_Homo sapiens_hsa043101.31182927
36Pathways in cancer_Homo sapiens_hsa052001.27854473
37TNF signaling pathway_Homo sapiens_hsa046681.27349304
38Basal transcription factors_Homo sapiens_hsa030221.25451513
39Dorso-ventral axis formation_Homo sapiens_hsa043201.24994008
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23575102
41Amoebiasis_Homo sapiens_hsa051461.22482392
42Ras signaling pathway_Homo sapiens_hsa040141.20728535
43Tight junction_Homo sapiens_hsa045301.18729395
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16767276
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16590416
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.16476848
47Sulfur metabolism_Homo sapiens_hsa009201.15343772
48Hedgehog signaling pathway_Homo sapiens_hsa043401.15119314
49Glutathione metabolism_Homo sapiens_hsa004801.14592658
50Renal cell carcinoma_Homo sapiens_hsa052111.13689223
51Gap junction_Homo sapiens_hsa045401.12191032
52Renin secretion_Homo sapiens_hsa049241.11599096
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10752337
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09258630
55Glioma_Homo sapiens_hsa052141.06746881
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.05784461
57Thyroid cancer_Homo sapiens_hsa052161.04063136
58HIF-1 signaling pathway_Homo sapiens_hsa040661.02937603
59Chronic myeloid leukemia_Homo sapiens_hsa052201.01776817
60Endometrial cancer_Homo sapiens_hsa052131.00842361
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.00145407
62Platelet activation_Homo sapiens_hsa046110.99294453
63HTLV-I infection_Homo sapiens_hsa051660.99135896
64Notch signaling pathway_Homo sapiens_hsa043300.98721411
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96684774
66Viral myocarditis_Homo sapiens_hsa054160.96210874
67Salmonella infection_Homo sapiens_hsa051320.95460132
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92330420
69Estrogen signaling pathway_Homo sapiens_hsa049150.91893866
70Shigellosis_Homo sapiens_hsa051310.90441422
71African trypanosomiasis_Homo sapiens_hsa051430.89437666
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88736505
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.88601387
74Rheumatoid arthritis_Homo sapiens_hsa053230.85585613
75Oxytocin signaling pathway_Homo sapiens_hsa049210.83703435
76cAMP signaling pathway_Homo sapiens_hsa040240.82801973
77Toxoplasmosis_Homo sapiens_hsa051450.80502497
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79683128
79GnRH signaling pathway_Homo sapiens_hsa049120.78830800
80Colorectal cancer_Homo sapiens_hsa052100.78682811
812-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78579881
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76887629
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76660871
84MAPK signaling pathway_Homo sapiens_hsa040100.75847539
85ErbB signaling pathway_Homo sapiens_hsa040120.75046789
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74761253
87Thyroid hormone synthesis_Homo sapiens_hsa049180.74379036
88Circadian entrainment_Homo sapiens_hsa047130.73640944
89Cholinergic synapse_Homo sapiens_hsa047250.71636740
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71378497
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70953648
92Cocaine addiction_Homo sapiens_hsa050300.70575528
93Hepatitis B_Homo sapiens_hsa051610.69542412
94Olfactory transduction_Homo sapiens_hsa047400.69308145
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65146748
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65004301
97Long-term depression_Homo sapiens_hsa047300.64573354
98VEGF signaling pathway_Homo sapiens_hsa043700.63862671
99Dopaminergic synapse_Homo sapiens_hsa047280.63359238
100Pancreatic cancer_Homo sapiens_hsa052120.63347769
101FoxO signaling pathway_Homo sapiens_hsa040680.63010104
102Morphine addiction_Homo sapiens_hsa050320.62469800
103Prolactin signaling pathway_Homo sapiens_hsa049170.62257151
104Endocytosis_Homo sapiens_hsa041440.60456919
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60377261
106Protein export_Homo sapiens_hsa030600.58518005
107Amphetamine addiction_Homo sapiens_hsa050310.57591047
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57178293
109Long-term potentiation_Homo sapiens_hsa047200.56420055
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55225442
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.55079327
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.55053547
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54987554
114Gastric acid secretion_Homo sapiens_hsa049710.54658808
115Hepatitis C_Homo sapiens_hsa051600.54585235
116Pertussis_Homo sapiens_hsa051330.53692799
117Calcium signaling pathway_Homo sapiens_hsa040200.53430536
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53192597
119p53 signaling pathway_Homo sapiens_hsa041150.52654469
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52517662
121Osteoclast differentiation_Homo sapiens_hsa043800.51813254
122Legionellosis_Homo sapiens_hsa051340.51139846
123Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50203386
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47743134
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47089728
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46966745
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45829734
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44708141
129Chemical carcinogenesis_Homo sapiens_hsa052040.44109004
130Apoptosis_Homo sapiens_hsa042100.43390833
131Renin-angiotensin system_Homo sapiens_hsa046140.40522889
132Regulation of autophagy_Homo sapiens_hsa041400.36560652
133GABAergic synapse_Homo sapiens_hsa047270.35152968
134Fructose and mannose metabolism_Homo sapiens_hsa000510.32562860
135Biosynthesis of amino acids_Homo sapiens_hsa012300.30856818
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.30832446
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28990730
138Glutamatergic synapse_Homo sapiens_hsa047240.24896081
139Serotonergic synapse_Homo sapiens_hsa047260.24454953
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.24387411

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