STC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collagen fibril organization (GO:0030199)5.52576052
2bone trabecula formation (GO:0060346)5.01419852
3COPI coating of Golgi vesicle (GO:0048205)4.95058982
4Golgi transport vesicle coating (GO:0048200)4.95058982
5endodermal cell differentiation (GO:0035987)4.86108969
6apoptotic process involved in morphogenesis (GO:0060561)4.68103044
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.41927660
8type B pancreatic cell proliferation (GO:0044342)4.34169995
9protein retention in ER lumen (GO:0006621)4.29532126
10planar cell polarity pathway involved in neural tube closure (GO:0090179)4.25719074
11sarcomere organization (GO:0045214)4.25273190
12regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.24602342
13plasma membrane repair (GO:0001778)4.13266485
14chondrocyte proliferation (GO:0035988)4.13072734
15epithelial cell fate commitment (GO:0072148)4.13004757
16basement membrane organization (GO:0071711)4.08603620
17interferon-gamma secretion (GO:0072643)4.06876990
18paraxial mesoderm development (GO:0048339)3.98452403
19regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.93685412
20kidney mesenchyme development (GO:0072074)3.92791259
21sequestering of extracellular ligand from receptor (GO:0035581)3.87246834
22regulation of translational fidelity (GO:0006450)3.86676291
23apoptotic process involved in development (GO:1902742)3.71937047
24regulation of hippo signaling (GO:0035330)3.70251079
25substrate-dependent cell migration (GO:0006929)3.68252467
26regulation of clathrin-mediated endocytosis (GO:2000369)3.66496429
27protein heterotrimerization (GO:0070208)3.64201052
28intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)3.58981499
29negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.58782372
30cortical actin cytoskeleton organization (GO:0030866)3.57443446
31peptidyl-proline hydroxylation (GO:0019511)3.55738358
32regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.55371700
33positive regulation of blood vessel endothelial cell migration (GO:0043536)3.54930510
34extracellular matrix assembly (GO:0085029)3.49773435
35collagen metabolic process (GO:0032963)3.45223683
36establishment of apical/basal cell polarity (GO:0035089)3.44576086
37chondrocyte development (GO:0002063)3.43799361
38metanephric mesenchyme development (GO:0072075)3.41139824
39tooth mineralization (GO:0034505)3.39772256
40cardiac myofibril assembly (GO:0055003)3.39540518
41adherens junction assembly (GO:0034333)3.38637943
42dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.38620734
43focal adhesion assembly (GO:0048041)3.33859367
44cell-substrate adherens junction assembly (GO:0007045)3.33859367
45heterochromatin organization (GO:0070828)3.25789362
46cellular response to vitamin (GO:0071295)3.25074379
47collagen catabolic process (GO:0030574)3.23808484
48cortical cytoskeleton organization (GO:0030865)3.23059232
49protein hydroxylation (GO:0018126)3.22339064
50endothelial cell morphogenesis (GO:0001886)3.22324485
51hippo signaling (GO:0035329)3.19935420
52negative regulation of histone methylation (GO:0031061)3.19479288
53negative regulation of chondrocyte differentiation (GO:0032331)3.19358797
54skin morphogenesis (GO:0043589)3.19132030
55wound healing, spreading of epidermal cells (GO:0035313)3.18669100
56cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.18571059
57cell migration involved in heart development (GO:0060973)3.18267647
58Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.17657564
59multicellular organismal macromolecule metabolic process (GO:0044259)3.17314730
60negative regulation of cell size (GO:0045792)3.17018566
61cell-substrate junction assembly (GO:0007044)3.15070913
62vascular endothelial growth factor signaling pathway (GO:0038084)3.10669241
63polarized epithelial cell differentiation (GO:0030859)3.09861540
64branching involved in salivary gland morphogenesis (GO:0060445)3.08271507
65extracellular matrix disassembly (GO:0022617)3.06729500
66glomerular basement membrane development (GO:0032836)3.05868597
67negative regulation of cardiac muscle tissue growth (GO:0055022)3.05175034
68negative regulation of heart growth (GO:0061117)3.05175034
69regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.04377666
70heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.04329646
71regulation of establishment of planar polarity (GO:0090175)3.02857139
72negative regulation of potassium ion transmembrane transport (GO:1901380)3.02185346
73positive regulation of endothelial cell apoptotic process (GO:2000353)3.01823535
74proline biosynthetic process (GO:0006561)3.01781876
75regulation of posttranscriptional gene silencing (GO:0060147)3.01332243
76regulation of gene silencing by miRNA (GO:0060964)3.01332243
77regulation of gene silencing by RNA (GO:0060966)3.01332243
78stress fiber assembly (GO:0043149)3.01078799
79establishment of monopolar cell polarity (GO:0061162)2.98739286
80establishment or maintenance of monopolar cell polarity (GO:0061339)2.98739286
81multicellular organismal metabolic process (GO:0044236)2.98606217
82vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.98467975
83notochord development (GO:0030903)2.98219142
84epithelial cell-cell adhesion (GO:0090136)2.97968983
85mesenchymal-epithelial cell signaling (GO:0060638)2.96052911
86cochlea morphogenesis (GO:0090103)2.95028087
87wound healing, spreading of cells (GO:0044319)2.94369559
88virion attachment to host cell (GO:0019062)2.92651464
89adhesion of symbiont to host cell (GO:0044650)2.92651464
90negative regulation of embryonic development (GO:0045992)2.92278504
91retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92207685
92multicellular organismal catabolic process (GO:0044243)2.90846871
93retina vasculature morphogenesis in camera-type eye (GO:0061299)2.90356315
94regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.89787887
95COPII vesicle coating (GO:0048208)2.89365985
96endocardial cushion development (GO:0003197)2.88349521
97regulation of cardioblast differentiation (GO:0051890)2.88232078
984-hydroxyproline metabolic process (GO:0019471)2.88227725
99branching involved in mammary gland duct morphogenesis (GO:0060444)2.88025756
100cardiac muscle cell development (GO:0055013)2.87775772
101negative regulation of smooth muscle cell migration (GO:0014912)2.84812717
102muscle cell migration (GO:0014812)2.83963466
103negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.82178582
104negative regulation of fatty acid transport (GO:2000192)2.81759881
105positive regulation of SMAD protein import into nucleus (GO:0060391)2.80611586
106mRNA stabilization (GO:0048255)2.79792849
107RNA stabilization (GO:0043489)2.79792849
108bundle of His cell to Purkinje myocyte communication (GO:0086069)2.79517049
109insulin-like growth factor receptor signaling pathway (GO:0048009)2.79512492
110cellular response to vitamin D (GO:0071305)2.79244090
111actin-myosin filament sliding (GO:0033275)2.79207371
112muscle filament sliding (GO:0030049)2.79207371
113spliceosomal tri-snRNP complex assembly (GO:0000244)2.78314370
114glial cell proliferation (GO:0014009)2.78063041
115desmosome organization (GO:0002934)2.77479580
116extracellular matrix organization (GO:0030198)2.77247040
117adhesion of symbiont to host (GO:0044406)2.76755731
118developmental programmed cell death (GO:0010623)2.76506840
119extracellular structure organization (GO:0043062)2.76196375
120embryonic camera-type eye development (GO:0031076)2.75358876
121positive regulation of osteoblast proliferation (GO:0033690)2.73319623
122regulation of apoptotic process involved in morphogenesis (GO:1902337)2.73312847
123cell migration involved in sprouting angiogenesis (GO:0002042)2.73258253
124extracellular fibril organization (GO:0043206)2.72580247
125negative regulation of axon extension involved in axon guidance (GO:0048843)2.72137264
126regulation of plasminogen activation (GO:0010755)2.71905510
127regulation of extracellular matrix disassembly (GO:0010715)2.70595581
128hyaluronan catabolic process (GO:0030214)2.69789971
129cardiac cell development (GO:0055006)2.69568853
130cell adhesion mediated by integrin (GO:0033627)2.68827186
131convergent extension (GO:0060026)2.67235581
132barbed-end actin filament capping (GO:0051016)2.64840512
133trabecula formation (GO:0060343)2.64488325
134heparan sulfate proteoglycan metabolic process (GO:0030201)2.64046024
135vesicle coating (GO:0006901)2.63312934
136regulation of SMAD protein import into nucleus (GO:0060390)2.63189809
137respiratory system process (GO:0003016)2.62974523
138protein localization to cell surface (GO:0034394)2.62612910
139regulation of histone H3-K9 methylation (GO:0051570)2.61924965
140hypotonic response (GO:0006971)2.61396933
141muscle organ morphogenesis (GO:0048644)2.60555286
142activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60332031
143hemidesmosome assembly (GO:0031581)2.59911355
144extracellular regulation of signal transduction (GO:1900115)2.59694925
145extracellular negative regulation of signal transduction (GO:1900116)2.59694925
146negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.59327176
147substrate adhesion-dependent cell spreading (GO:0034446)2.57586424
148atrioventricular valve morphogenesis (GO:0003181)2.56555891
149positive regulation of hormone biosynthetic process (GO:0046886)2.56314839
150anterior/posterior axis specification, embryo (GO:0008595)2.56274506
151regulation of tight junction assembly (GO:2000810)2.56155149
152actomyosin structure organization (GO:0031032)2.55733764
153positive regulation of endothelial cell migration (GO:0010595)2.55399651
154gastrulation with mouth forming second (GO:0001702)2.55270161
155mammary gland epithelial cell proliferation (GO:0033598)2.55150748
156regulation of mammary gland epithelial cell proliferation (GO:0033599)2.53480050
157morphogenesis of embryonic epithelium (GO:0016331)2.52930560
158pre-miRNA processing (GO:0031054)2.52395336
159nuclear pore complex assembly (GO:0051292)2.52005690
160negative regulation of RNA splicing (GO:0033119)2.51164700
161myofibril assembly (GO:0030239)2.50455744
162muscle cell fate commitment (GO:0042693)2.50415682
163endosome to melanosome transport (GO:0035646)2.50093764
164endosome to pigment granule transport (GO:0043485)2.50093764
165NLS-bearing protein import into nucleus (GO:0006607)2.48855238
166folic acid-containing compound biosynthetic process (GO:0009396)2.48556828
167myelination in peripheral nervous system (GO:0022011)2.47857042
168peripheral nervous system axon ensheathment (GO:0032292)2.47857042
169oligosaccharide biosynthetic process (GO:0009312)2.45202826
170positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.45102991
171protein localization to endosome (GO:0036010)2.43859258
172protein localization to kinetochore (GO:0034501)2.42576611
173maternal placenta development (GO:0001893)2.41980523
174actin-mediated cell contraction (GO:0070252)2.41025315
175nuclear pore organization (GO:0006999)2.40811894
176positive regulation of histone deacetylation (GO:0031065)2.38284345
177intestinal epithelial cell development (GO:0060576)2.37644099
178atrial septum morphogenesis (GO:0060413)2.34440673
179adherens junction organization (GO:0034332)2.32804378

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.39684610
2PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.20658438
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.49716665
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98625336
5E2F7_22180533_ChIP-Seq_HELA_Human2.98270925
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.94305498
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.94305498
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.94305498
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91208922
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.81342000
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.80959043
12* HIF1A_21447827_ChIP-Seq_MCF-7_Human2.76662432
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.61429779
14ZNF263_19887448_ChIP-Seq_K562_Human2.31145426
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26041278
16CLOCK_20551151_ChIP-Seq_293T_Human2.20203888
17SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.14145253
18* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.13479904
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09039230
20BRD4_25478319_ChIP-Seq_HGPS_Human2.07536149
21ESR1_15608294_ChIP-ChIP_MCF-7_Human2.07419396
22* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.05260257
23CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.02500299
24MYC_22102868_ChIP-Seq_BL_Human1.99853064
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.96801422
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95572632
27* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90780429
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.88319381
29* ESR2_21235772_ChIP-Seq_MCF-7_Human1.87185361
30* ATF3_27146783_Chip-Seq_COLON_Human1.87081601
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86721382
32POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.84992848
33* ESR1_21235772_ChIP-Seq_MCF-7_Human1.80167420
34* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.80140012
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.78032474
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.75678528
37* MYC_18555785_ChIP-Seq_MESCs_Mouse1.73578424
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72977589
39* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68979471
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67933344
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.65517078
42EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.65217943
43RACK7_27058665_Chip-Seq_MCF-7_Human1.63114842
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62073168
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60868939
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59594602
47KDM2B_26808549_Chip-Seq_DND41_Human1.57987952
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57787379
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56938708
50TP53_22127205_ChIP-Seq_IMR90_Human1.56855735
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56090891
52RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53120536
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.53020998
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.50199616
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.49846359
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48002268
57ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46640425
58* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46517908
59P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44483183
60SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44237713
61CJUN_26792858_Chip-Seq_BT549_Human1.43838227
62* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43227494
63* LXR_22292898_ChIP-Seq_THP-1_Human1.41871844
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.40562191
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.40403741
66PPAR_26484153_Chip-Seq_NCI-H1993_Human1.40115881
67* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39651014
68AR_21909140_ChIP-Seq_LNCAP_Human1.38815865
69* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37819047
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35818821
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35672521
72SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33847969
73TBX20_22080862_ChIP-Seq_HEART_Mouse1.33038131
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.33038131
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32931936
76* KDM2B_26808549_Chip-Seq_K562_Human1.32449320
77* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32409336
78NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32265610
79* TP53_20018659_ChIP-ChIP_R1E_Mouse1.30779633
80NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29947454
81TCF7_22412390_ChIP-Seq_EML_Mouse1.28746393
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27718051
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27718051
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.26654513
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25450638
86* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.25120242
87TCF3_18692474_ChIP-Seq_MESCs_Mouse1.23793336
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.23644932
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23271919
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20977874
91UBF1/2_26484160_Chip-Seq_HMECs_Human1.20799188
92* NANOG_21062744_ChIP-ChIP_HESCs_Human1.20259283
93SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20152045
94SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20002732
95* GATA6_25053715_ChIP-Seq_YYC3_Human1.19866846
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18450981
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18376540
98POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17511795
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.15698633
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14145698
101OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13623396
102TP53_23651856_ChIP-Seq_MEFs_Mouse1.12682935
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11515270
104TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11373825
105ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11003950
106KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10306923
107* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10262661
108SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08076487
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07641447
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07579932
111E2F4_17652178_ChIP-ChIP_JURKAT_Human1.07446337
112MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07268058
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.06465637
114* CHD1_26751641_Chip-Seq_LNCaP_Human1.06434125
115TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06034910
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03985460
117NCOR1_26117541_ChIP-Seq_K562_Human1.03867693
118SA1_22415368_ChIP-Seq_MEFs_Mouse1.03750342
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03620207
120* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.03427300
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03347368
122MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03258185
123DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02595669
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.02071645
125NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00535835
126RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00457795
127CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97002996
128* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96704604
129* ERG_21242973_ChIP-ChIP_JURKAT_Human0.95639062
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94747907
131RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94115996
132EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94115996
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93129249
134TP53_18474530_ChIP-ChIP_U2OS_Human0.92620436
135TET1_21490601_ChIP-Seq_MESCs_Mouse0.92313703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.75436120
2MP0005248_abnormal_Harderian_gland3.61442509
3MP0003279_aneurysm3.37231996
4MP0005257_abnormal_intraocular_pressure2.98383557
5MP0004084_abnormal_cardiac_muscle2.82762811
6MP0000751_myopathy2.66291924
7MP0005623_abnormal_meninges_morphology2.64943541
8MP0003566_abnormal_cell_adhesion2.64899115
9MP0008438_abnormal_cutaneous_collagen2.63384474
10MP0010352_gastrointestinal_tract_polyps2.53955002
11MP0000750_abnormal_muscle_regeneration2.43484178
12MP0001346_abnormal_lacrimal_gland2.41814524
13MP0001542_abnormal_bone_strength2.27967026
14MP0002837_dystrophic_cardiac_calcinosis2.10024826
15MP0004185_abnormal_adipocyte_glucose2.05866831
16MP0002060_abnormal_skin_morphology1.98044382
17MP0004233_abnormal_muscle_weight1.96565482
18MP0000767_abnormal_smooth_muscle1.87584836
19MP0002877_abnormal_melanocyte_morpholog1.86946385
20MP0006054_spinal_hemorrhage1.86454835
21MP0010234_abnormal_vibrissa_follicle1.78176485
22MP0004087_abnormal_muscle_fiber1.77601873
23MP0005275_abnormal_skin_tensile1.76327856
24MP0010368_abnormal_lymphatic_system1.74478138
25MP0003646_muscle_fatigue1.73958102
26MP0009780_abnormal_chondrocyte_physiolo1.72985839
27MP0003950_abnormal_plasma_membrane1.72485382
28MP0009250_abnormal_appendicular_skeleto1.70233166
29MP0005666_abnormal_adipose_tissue1.66189121
30MP0000733_abnormal_muscle_development1.65871436
31MP0005503_abnormal_tendon_morphology1.63853552
32MP0005330_cardiomyopathy1.63730828
33MP0000534_abnormal_ureter_morphology1.63260092
34MP0010630_abnormal_cardiac_muscle1.59972932
35MP0004272_abnormal_basement_membrane1.59172424
36MP0004858_abnormal_nervous_system1.57558834
37MP0000537_abnormal_urethra_morphology1.52507726
38MP0001243_abnormal_dermal_layer1.50826619
39MP0003942_abnormal_urinary_system1.49305167
40MP0004130_abnormal_muscle_cell1.48920312
41MP0010030_abnormal_orbit_morphology1.48718596
42MP0003941_abnormal_skin_development1.48447678
43MP0005076_abnormal_cell_differentiation1.46866136
44MP0002234_abnormal_pharynx_morphology1.44478390
45MP0005375_adipose_tissue_phenotype1.43851411
46MP0001348_abnormal_lacrimal_gland1.42801139
47MP0002295_abnormal_pulmonary_circulatio1.42536482
48MP0003119_abnormal_digestive_system1.41729710
49MP0000013_abnormal_adipose_tissue1.39151611
50MP0002084_abnormal_developmental_patter1.35127440
51MP0004957_abnormal_blastocyst_morpholog1.34263207
52MP0004036_abnormal_muscle_relaxation1.32874103
53MP0003567_abnormal_fetal_cardiomyocyte1.31476186
54MP0000003_abnormal_adipose_tissue1.28587197
55MP0003283_abnormal_digestive_organ1.26413065
56MP0003221_abnormal_cardiomyocyte_apopto1.26205835
57MP0003935_abnormal_craniofacial_develop1.26185053
58MP0001727_abnormal_embryo_implantation1.26069175
59MP0004197_abnormal_fetal_growth/weight/1.25954565
60MP0005508_abnormal_skeleton_morphology1.25086488
61MP0004215_abnormal_myocardial_fiber1.23906036
62MP0003693_abnormal_embryo_hatching1.22924154
63MP0002085_abnormal_embryonic_tissue1.22516466
64MP0003755_abnormal_palate_morphology1.22385886
65MP0002088_abnormal_embryonic_growth/wei1.21886415
66MP0003984_embryonic_growth_retardation1.20762465
67MP0001672_abnormal_embryogenesis/_devel1.19217306
68MP0005380_embryogenesis_phenotype1.19217306
69MP0000759_abnormal_skeletal_muscle1.19178310
70MP0009053_abnormal_anal_canal1.17469642
71MP0008775_abnormal_heart_ventricle1.16298408
72MP0002106_abnormal_muscle_physiology1.14024636
73MP0001730_embryonic_growth_arrest1.13623628
74MP0006138_congestive_heart_failure1.13520765
75MP0003937_abnormal_limbs/digits/tail_de1.13143423
76MP0003123_paternal_imprinting1.13087051
77MP0002282_abnormal_trachea_morphology1.12913042
78MP0002086_abnormal_extraembryonic_tissu1.11569894
79MP0002111_abnormal_tail_morphology1.11453290
80MP0000428_abnormal_craniofacial_morphol1.10436129
81MP0003828_pulmonary_edema1.09980488
82MP0003300_gastrointestinal_ulcer1.09908012
83MP0005385_cardiovascular_system_phenoty1.09408239
84MP0001544_abnormal_cardiovascular_syste1.09408239
85MP0002269_muscular_atrophy1.08496942
86MP0002972_abnormal_cardiac_muscle1.08012391
87MP0001849_ear_inflammation1.07952663
88MP0003385_abnormal_body_wall1.06594913
89MP0000462_abnormal_digestive_system1.06054761
90MP0005023_abnormal_wound_healing1.04772421
91MP0002925_abnormal_cardiovascular_devel1.04424710
92MP0005197_abnormal_uvea_morphology1.02812943
93MP0003091_abnormal_cell_migration1.02544378
94MP0000762_abnormal_tongue_morphology1.01551459
95MP0000747_muscle_weakness1.00635325
96MP0000749_muscle_degeneration0.99880266
97MP0002697_abnormal_eye_size0.99097535
98MP0002896_abnormal_bone_mineralization0.98061049
99MP0001299_abnormal_eye_distance/0.97796752
100MP0005369_muscle_phenotype0.97512145
101MP0004264_abnormal_extraembryonic_tissu0.96099494
102MP0003115_abnormal_respiratory_system0.95916794
103MP0000350_abnormal_cell_proliferation0.94057995
104MP0002254_reproductive_system_inflammat0.93765797
105MP0003137_abnormal_impulse_conducting0.93667552
106MP0000266_abnormal_heart_morphology0.92623627
107MP0001697_abnormal_embryo_size0.92394735
108MP0002108_abnormal_muscle_morphology0.91898283
109MP0005620_abnormal_muscle_contractility0.90179192
110MP0004484_altered_response_of0.89991418
111MP0008932_abnormal_embryonic_tissue0.89700918
112MP0002080_prenatal_lethality0.88950779
113MP0009384_cardiac_valve_regurgitation0.88047553
114MP0005501_abnormal_skin_physiology0.88000305
115MP0000163_abnormal_cartilage_morphology0.86117949
116MP0001881_abnormal_mammary_gland0.85437051
117MP0001958_emphysema0.85402152
118MP0002115_abnormal_skeleton_extremities0.85140513
119MP0003121_genomic_imprinting0.84825115
120MP0000432_abnormal_head_morphology0.84324125
121MP0002089_abnormal_postnatal_growth/wei0.84098304
122MP0002116_abnormal_craniofacial_bone0.84043196
123MP0003111_abnormal_nucleus_morphology0.84022876
124MP0005595_abnormal_vascular_smooth0.83994631
125MP0000627_abnormal_mammary_gland0.83746644
126MP0002796_impaired_skin_barrier0.82631744
127MP0001879_abnormal_lymphatic_vessel0.82305437
128MP0004134_abnormal_chest_morphology0.81952466
129MP0000467_abnormal_esophagus_morphology0.80410255
130MP0005390_skeleton_phenotype0.79383279
131MP0000049_abnormal_middle_ear0.79225408
132MP0002932_abnormal_joint_morphology0.78680765
133MP0002113_abnormal_skeleton_development0.78611797
134MP0002249_abnormal_larynx_morphology0.78129201
135MP0001915_intracranial_hemorrhage0.72424919
136MP0002128_abnormal_blood_circulation0.71105748
137MP0005164_abnormal_response_to0.70674302
138MP0002114_abnormal_axial_skeleton0.70076641
139MP0000579_abnormal_nail_morphology0.69235566
140MP0003448_altered_tumor_morphology0.69158820
141MP0001614_abnormal_blood_vessel0.68830670
142MP0005058_abnormal_lysosome_morphology0.67575215
143MP0000538_abnormal_urinary_bladder0.66162902
144MP0005621_abnormal_cell_physiology0.65180488
145MP0001340_abnormal_eyelid_morphology0.64475674
146MP0010771_integument_phenotype0.64020357
147MP0001175_abnormal_lung_morphology0.62911900
148MP0005193_abnormal_anterior_eye0.61647019
149MP0000858_altered_metastatic_potential0.60958669
150MP0002092_abnormal_eye_morphology0.54447639

Predicted human phenotypes

RankGene SetZ-score
1Soft skin (HP:0000977)4.15612618
2Vascular tortuosity (HP:0004948)4.13964630
3Abnormality of dentin (HP:0010299)4.12321317
4Right ventricular cardiomyopathy (HP:0011663)3.82895765
5Arterial tortuosity (HP:0005116)3.82463964
6Follicular hyperkeratosis (HP:0007502)3.60260344
7Fragile skin (HP:0001030)3.52838168
8Wormian bones (HP:0002645)3.43474425
9Muscle fiber splitting (HP:0003555)3.43265697
10Vertebral compression fractures (HP:0002953)3.42681306
11Protrusio acetabuli (HP:0003179)3.31332363
12Ulnar bowing (HP:0003031)3.30398450
13Hypoplastic ischia (HP:0003175)3.24320834
14Increased connective tissue (HP:0009025)3.21012431
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.18668164
16Sudden death (HP:0001699)3.15421375
17Biconcave vertebral bodies (HP:0004586)3.09442817
18Spondylolisthesis (HP:0003302)2.99167123
19Shallow orbits (HP:0000586)2.95705738
20Bronchomalacia (HP:0002780)2.94391629
21Bowel diverticulosis (HP:0005222)2.90931976
22Ventricular tachycardia (HP:0004756)2.90871460
23Exercise-induced muscle cramps (HP:0003710)2.88525579
24Difficulty running (HP:0009046)2.88440747
25Dilatation of the ascending aorta (HP:0005111)2.86070853
26Ankle contracture (HP:0006466)2.84146504
27Peritonitis (HP:0002586)2.82551985
28Abnormality of the ischium (HP:0003174)2.78942120
29Hyporeflexia of lower limbs (HP:0002600)2.77671402
30Slender build (HP:0001533)2.77091088
31Metaphyseal cupping (HP:0003021)2.75520914
32Premature rupture of membranes (HP:0001788)2.72905377
33Mitral regurgitation (HP:0001653)2.68495484
34Joint laxity (HP:0001388)2.67743614
35Aortic regurgitation (HP:0001659)2.64080450
36Elbow flexion contracture (HP:0002987)2.63287965
37Abnormal delivery (HP:0001787)2.58928846
38Abnormality of the acetabulum (HP:0003170)2.53449895
39Upper limb amyotrophy (HP:0009129)2.46694236
40Distal upper limb amyotrophy (HP:0007149)2.46694236
41Cerebral aneurysm (HP:0004944)2.42009091
42Flat acetabular roof (HP:0003180)2.39682256
43Renal duplication (HP:0000075)2.39518150
44Hip contracture (HP:0003273)2.33174560
45Hyperacusis (HP:0010780)2.33090896
46Wide anterior fontanel (HP:0000260)2.32980043
47Overgrowth (HP:0001548)2.32387031
48Breech presentation (HP:0001623)2.27986578
49Type 1 muscle fiber predominance (HP:0003803)2.27240063
50Aortic aneurysm (HP:0004942)2.25972705
51Abnormality of the left ventricular outflow tract (HP:0011103)2.25861588
52Subaortic stenosis (HP:0001682)2.25861588
53Sex reversal (HP:0012245)2.25804436
54Abnormal sex determination (HP:0012244)2.25804436
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.23609751
56Osteolytic defects of the hand bones (HP:0009699)2.23609751
57Mildly elevated creatine phosphokinase (HP:0008180)2.23338147
58Generalized amyotrophy (HP:0003700)2.23306139
59Difficulty climbing stairs (HP:0003551)2.22812079
60Short nail (HP:0001799)2.21697182
61Hand muscle atrophy (HP:0009130)2.21627858
62Abnormality of the calf musculature (HP:0001430)2.21558272
63Distal lower limb amyotrophy (HP:0008944)2.20462780
64Absent frontal sinuses (HP:0002688)2.20335838
65Broad metatarsal (HP:0001783)2.20064143
66Disproportionate tall stature (HP:0001519)2.19593656
67Exostoses (HP:0100777)2.18901658
68Short humerus (HP:0005792)2.18675868
69Coronal craniosynostosis (HP:0004440)2.17755265
70Cervical subluxation (HP:0003308)2.15747934
71Bowing of the arm (HP:0006488)2.15582552
72Bowed forearm bones (HP:0003956)2.15582552
73Nonimmune hydrops fetalis (HP:0001790)2.14547315
74Rectal prolapse (HP:0002035)2.13352167
75Atrophic scars (HP:0001075)2.13004386
76Knee flexion contracture (HP:0006380)2.12190532
77Scapular winging (HP:0003691)2.12182557
78Abnormality of the calcaneus (HP:0008364)2.10886674
79Thin bony cortex (HP:0002753)2.10127131
80Ulnar deviation of the wrist (HP:0003049)2.09485976
81Lipoatrophy (HP:0100578)2.09485056
82Achilles tendon contracture (HP:0001771)2.07752940
83Aortic valve stenosis (HP:0001650)2.07537301
84Natal tooth (HP:0000695)2.06897790
85Hypoventilation (HP:0002791)2.06870121
86Epiphyseal dysplasia (HP:0002656)2.06722664
87Aneurysm (HP:0002617)2.06594166
88Mitral stenosis (HP:0001718)2.05283043
89Congenital glaucoma (HP:0001087)2.04813568
90Atrial fibrillation (HP:0005110)2.04609223
91Enlarged penis (HP:0000040)2.04501916
92Spinal cord compression (HP:0002176)2.02878916
93Lymphangioma (HP:0100764)2.00842345
94Sparse lateral eyebrow (HP:0005338)2.00251714
95Round ear (HP:0100830)1.99596594
96Primary atrial arrhythmia (HP:0001692)1.99364191
97Premature skin wrinkling (HP:0100678)1.99279931
98Mitral valve prolapse (HP:0001634)1.98034310
99Joint stiffness (HP:0001387)1.97452715
100Aortic dissection (HP:0002647)1.96946073
101Radial bowing (HP:0002986)1.96169278
102Cortical dysplasia (HP:0002539)1.95870626
103Aplasia/hypoplasia of the humerus (HP:0006507)1.95265368
104Abnormal vertebral ossification (HP:0100569)1.95241649
105Increased density of long bones (HP:0006392)1.94615620
106Deviation of the hallux (HP:0010051)1.94230992
107Supraventricular arrhythmia (HP:0005115)1.93993440
108Hallux valgus (HP:0001822)1.92384715
109Asymmetry of the thorax (HP:0001555)1.91886474
110Genu recurvatum (HP:0002816)1.91318633
111Wrist flexion contracture (HP:0001239)1.91082341
112Infantile muscular hypotonia (HP:0008947)1.91015389
113Abnormality of the umbilical cord (HP:0010881)1.90890265
114EMG: myopathic abnormalities (HP:0003458)1.89691085
115Supraventricular tachycardia (HP:0004755)1.89600992
116Long toe (HP:0010511)1.89095123
117Syringomyelia (HP:0003396)1.89094635
118Spinal cord lesions (HP:0100561)1.89094635
119Inguinal hernia (HP:0000023)1.89038124
120Ectopia lentis (HP:0001083)1.88963015
121Osteoarthritis (HP:0002758)1.88897535
122Distal lower limb muscle weakness (HP:0009053)1.88567694
123Aplasia of the musculature (HP:0100854)1.88343423
124Medulloblastoma (HP:0002885)1.87948432
125Delayed closure of the anterior fontanelle (HP:0001476)1.87739592
126Delayed cranial suture closure (HP:0000270)1.87275409
127Redundant skin (HP:0001582)1.86971225
128Protruding ear (HP:0000411)1.85417668
129Cupped ribs (HP:0000887)1.85368960
130Increased variability in muscle fiber diameter (HP:0003557)1.85195589
131Limited hip movement (HP:0008800)1.84680923
132Camptodactyly of toe (HP:0001836)1.84328610
133Mild short stature (HP:0003502)1.84004017
134Cardiovascular calcification (HP:0011915)1.83069981
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82637332
136Ependymoma (HP:0002888)1.82380064
137Morphological abnormality of the middle ear (HP:0008609)1.82089217
138Abnormality of the Achilles tendon (HP:0005109)1.81999735
139Flat cornea (HP:0007720)1.81980421
140Abnormality of the pubic bones (HP:0003172)1.80596284
141Mesomelia (HP:0003027)1.80596052
142Pterygium (HP:0001059)1.80023515
143Hyperextensible skin (HP:0000974)1.79239188
144Limb-girdle muscle atrophy (HP:0003797)1.78356928
145Astrocytoma (HP:0009592)1.78107904
146Abnormality of the astrocytes (HP:0100707)1.78107904
147Vertebral hypoplasia (HP:0008417)1.77868695
148Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77868695
149Subacute progressive viral hepatitis (HP:0006572)1.77084941
150Coxa vara (HP:0002812)1.74487865
151Persistence of primary teeth (HP:0006335)1.73848202
152Trismus (HP:0000211)1.73420898
153Ovoid vertebral bodies (HP:0003300)1.72350047
154Abnormality of skeletal muscle fiber size (HP:0012084)1.71899793
155Abnormality of the 4th metacarpal (HP:0010012)1.71172340
156Missing ribs (HP:0000921)1.70264028
157Spinal rigidity (HP:0003306)1.69880250
158Bladder diverticulum (HP:0000015)1.69312277
159Blue sclerae (HP:0000592)1.68066941
160Curly hair (HP:0002212)1.67656961
161Broad thumb (HP:0011304)1.65379353
162Calf muscle hypertrophy (HP:0008981)1.64740372
163Cystic hygroma (HP:0000476)1.64590303
164Thin ribs (HP:0000883)1.63086518
165Neonatal short-limb short stature (HP:0008921)1.62765453
166Exercise-induced myalgia (HP:0003738)1.62644797
167Apathy (HP:0000741)1.62347878
168Congenital hip dislocation (HP:0001374)1.61988141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.75520832
2PKN25.05337398
3TRIB34.62296109
4BMX3.99114291
5TNK23.38290951
6TTN3.33944659
7CDK122.61705720
8NTRK12.30663276
9EEF2K2.25213125
10LATS12.09947108
11SMG12.08218605
12DDR21.91870158
13PRPF4B1.89752179
14MUSK1.82097374
15PDGFRA1.71132652
16LATS21.66859350
17TAOK21.61561871
18LRRK21.60151322
19RPS6KB21.50897395
20ALK1.46231897
21LMTK21.40434015
22DMPK1.37637200
23STK381.36462565
24PTK61.32639634
25MOS1.30026057
26NEK11.28051039
27PIM21.19588835
28PIK3CA1.18757426
29FGFR41.14899158
30FGFR11.14138203
31LIMK11.12928423
32MTOR1.12696416
33IRAK31.11974867
34PTK21.11917218
35FER1.06502434
36AKT21.06335866
37TYRO31.05251745
38RIPK11.03988834
39RPS6KA21.03405722
40SIK11.01685940
41ERN11.00731977
42PDK40.95543330
43PDK30.95543330
44PHKG10.93691964
45PHKG20.93691964
46STK100.91802523
47EPHB20.90454628
48PAK40.88488737
49PAK20.87542352
50CDK60.86801866
51STK38L0.85321685
52ROCK20.84474335
53PDGFRB0.83417113
54MAP3K100.79772513
55TGFBR20.78724267
56CDK80.78691293
57TESK10.75872169
58DAPK30.75027447
59MET0.72450638
60ILK0.72142064
61ICK0.72003385
62ROCK10.70036031
63MAP3K80.68978726
64MAP3K110.68071101
65PIK3CG0.67674709
66EIF2AK10.65354655
67PAK30.64718412
68PRKD10.64114663
69NME20.63712255
70CAMK1D0.62508073
71SCYL20.62312184
72MELK0.62213093
73ARAF0.61425608
74RET0.60815150
75MAP3K30.60717894
76MAPKAPK30.58890277
77FLT30.58455427
78ABL20.56412879
79STK30.55190099
80MAP3K70.54082679
81CDK70.53960919
82RPS6KL10.53918687
83RPS6KC10.53918687
84PRKD20.53802901
85CAMK2G0.53319409
86NEK20.50493930
87WNK10.48814269
88KSR20.48797999
89EPHB10.48750611
90BCKDK0.47893233
91TTK0.46339191
92PRKCI0.46040173
93PRKG20.45582006
94CDK40.44835837
95PDK20.44758416
96CSNK1E0.44627956
97ERBB40.44484762
98PAK60.43864077
99PAK10.43244946
100CDC42BPA0.43058581
101TRPM70.42722377
102MKNK20.41512486
103BRD40.41211320
104CLK10.41047534
105TAOK10.41000075
106AKT30.40713538
107MAP2K20.40059078
108MST1R0.39342358
109MAP3K90.39243183
110MAP3K60.38923673
111GSK3A0.38901818
112CDK150.38487514
113TESK20.38381683
114CAMK2B0.37914060
115NEK90.37326365
116MAP3K50.36419446
117CSK0.35826425
118CAMK2D0.35654292
119MAP3K130.35540446
120MAPK70.35390140
121CDK11A0.35314597
122MAPKAPK20.35285342
123PRKD30.34822200
124CDK180.34552429
125RPS6KA60.34393672
126CDC70.33466517
127STK110.33210932
128ERBB30.33048569
129AURKA0.32825196
130MAP2K10.32424307
131TAF10.32363982
132BRSK10.31618872
133CSNK1D0.31265625
134MYLK0.30726468
135AURKB0.30686788
136CHEK10.30074357
137CDK20.29499998
138MKNK10.29239304
139DYRK1B0.27947049
140AKT10.27313951
141EGFR0.26527411
142OBSCN0.25990849

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.44269728
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.24269441
3Focal adhesion_Homo sapiens_hsa045102.24118949
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.19972497
5Dilated cardiomyopathy_Homo sapiens_hsa054142.17885331
6Adherens junction_Homo sapiens_hsa045202.13030007
7Proteoglycans in cancer_Homo sapiens_hsa052051.99510954
8Endometrial cancer_Homo sapiens_hsa052131.97332811
9Central carbon metabolism in cancer_Homo sapiens_hsa052301.96528107
10Small cell lung cancer_Homo sapiens_hsa052221.91853961
11Glycosaminoglycan degradation_Homo sapiens_hsa005311.88441478
12Hippo signaling pathway_Homo sapiens_hsa043901.82444224
13Bladder cancer_Homo sapiens_hsa052191.80722311
14MicroRNAs in cancer_Homo sapiens_hsa052061.80257819
15Chronic myeloid leukemia_Homo sapiens_hsa052201.78055355
16Lysine degradation_Homo sapiens_hsa003101.77474693
17Notch signaling pathway_Homo sapiens_hsa043301.77336256
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75983915
19Viral myocarditis_Homo sapiens_hsa054161.73644925
20Tight junction_Homo sapiens_hsa045301.68740566
21mTOR signaling pathway_Homo sapiens_hsa041501.63851064
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51429175
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.49755832
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48004494
25Protein digestion and absorption_Homo sapiens_hsa049741.46348168
26Renal cell carcinoma_Homo sapiens_hsa052111.42297640
27N-Glycan biosynthesis_Homo sapiens_hsa005101.40177884
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39501181
29HIF-1 signaling pathway_Homo sapiens_hsa040661.39148623
30Basal cell carcinoma_Homo sapiens_hsa052171.36441738
31Other glycan degradation_Homo sapiens_hsa005111.35962241
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35853067
33Fatty acid biosynthesis_Homo sapiens_hsa000611.31108445
34Insulin signaling pathway_Homo sapiens_hsa049101.29917904
35Acute myeloid leukemia_Homo sapiens_hsa052211.28832549
36Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25672636
37Biosynthesis of amino acids_Homo sapiens_hsa012301.23395189
38TGF-beta signaling pathway_Homo sapiens_hsa043501.23066025
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22380848
40One carbon pool by folate_Homo sapiens_hsa006701.21600493
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.18081284
42Amoebiasis_Homo sapiens_hsa051461.17906817
43Prion diseases_Homo sapiens_hsa050201.17752436
44Thyroid cancer_Homo sapiens_hsa052161.16459150
45PI3K-Akt signaling pathway_Homo sapiens_hsa041511.16132301
46Melanoma_Homo sapiens_hsa052181.16032452
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.14260403
48VEGF signaling pathway_Homo sapiens_hsa043701.12845945
49Non-small cell lung cancer_Homo sapiens_hsa052231.12791255
50RNA transport_Homo sapiens_hsa030131.11216807
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08752764
52Pancreatic cancer_Homo sapiens_hsa052121.07761080
53Glioma_Homo sapiens_hsa052141.06328424
54ErbB signaling pathway_Homo sapiens_hsa040121.04592796
55Colorectal cancer_Homo sapiens_hsa052101.04255298
56AMPK signaling pathway_Homo sapiens_hsa041521.03915941
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03777731
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.01425065
59Melanogenesis_Homo sapiens_hsa049161.01020697
60Vibrio cholerae infection_Homo sapiens_hsa051100.99282609
61Carbon metabolism_Homo sapiens_hsa012000.99218511
62Prostate cancer_Homo sapiens_hsa052150.97924728
63Insulin resistance_Homo sapiens_hsa049310.97094235
64Axon guidance_Homo sapiens_hsa043600.96297132
65mRNA surveillance pathway_Homo sapiens_hsa030150.95404103
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.93234550
67HTLV-I infection_Homo sapiens_hsa051660.93193896
68Viral carcinogenesis_Homo sapiens_hsa052030.91895052
69Pathways in cancer_Homo sapiens_hsa052000.90693772
70Pentose phosphate pathway_Homo sapiens_hsa000300.90377545
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90200820
72Fat digestion and absorption_Homo sapiens_hsa049750.89943790
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88341412
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88114595
75Hedgehog signaling pathway_Homo sapiens_hsa043400.84654971
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82560992
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.82123673
78Adipocytokine signaling pathway_Homo sapiens_hsa049200.81935146
79p53 signaling pathway_Homo sapiens_hsa041150.81139836
80Estrogen signaling pathway_Homo sapiens_hsa049150.79712556
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77730543
82Dorso-ventral axis formation_Homo sapiens_hsa043200.77554601
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74154801
84Pancreatic secretion_Homo sapiens_hsa049720.73811600
85Endocytosis_Homo sapiens_hsa041440.73521068
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73038071
87Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72885953
88Rap1 signaling pathway_Homo sapiens_hsa040150.71895521
89Shigellosis_Homo sapiens_hsa051310.71332845
90Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70982476
91Propanoate metabolism_Homo sapiens_hsa006400.68144621
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68074553
93Glucagon signaling pathway_Homo sapiens_hsa049220.67818512
94Selenocompound metabolism_Homo sapiens_hsa004500.67025311
95Fructose and mannose metabolism_Homo sapiens_hsa000510.65447717
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.64982474
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64422703
98Toxoplasmosis_Homo sapiens_hsa051450.63655812
99Wnt signaling pathway_Homo sapiens_hsa043100.63473482
100Cardiac muscle contraction_Homo sapiens_hsa042600.63076567
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62461873
102Galactose metabolism_Homo sapiens_hsa000520.62392139
103Lysosome_Homo sapiens_hsa041420.62252938
104FoxO signaling pathway_Homo sapiens_hsa040680.60070210
105Spliceosome_Homo sapiens_hsa030400.59380435
106Vitamin B6 metabolism_Homo sapiens_hsa007500.58760041
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.58642092
108Prolactin signaling pathway_Homo sapiens_hsa049170.58035344
109Cell cycle_Homo sapiens_hsa041100.57495658
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.57204802
111Apoptosis_Homo sapiens_hsa042100.56781550
112Ras signaling pathway_Homo sapiens_hsa040140.56050292
113Thyroid hormone synthesis_Homo sapiens_hsa049180.55298171
114Sphingolipid metabolism_Homo sapiens_hsa006000.53727747
115Platelet activation_Homo sapiens_hsa046110.52976640
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52563998
117Hepatitis B_Homo sapiens_hsa051610.51244922
118GnRH signaling pathway_Homo sapiens_hsa049120.47422992
119Gap junction_Homo sapiens_hsa045400.46987477
120TNF signaling pathway_Homo sapiens_hsa046680.46355508
121Choline metabolism in cancer_Homo sapiens_hsa052310.45189492
122MAPK signaling pathway_Homo sapiens_hsa040100.44925396
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42673285
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.42564071
125Sulfur relay system_Homo sapiens_hsa041220.41938267
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41510410
127Hepatitis C_Homo sapiens_hsa051600.40170356
128Pyruvate metabolism_Homo sapiens_hsa006200.39989300

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