STEAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)4.85751135
2protein maturation by protein folding (GO:0022417)4.48102396
3collagen fibril organization (GO:0030199)4.33744413
4iron ion import (GO:0097286)4.10573101
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.09439295
6folic acid-containing compound biosynthetic process (GO:0009396)4.07885458
7negative regulation of fatty acid transport (GO:2000192)3.86066504
8protein retention in ER lumen (GO:0006621)3.75490936
9Golgi transport vesicle coating (GO:0048200)3.73203538
10COPI coating of Golgi vesicle (GO:0048205)3.73203538
11regulation of plasminogen activation (GO:0010755)3.72877796
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61425847
13UDP-N-acetylglucosamine metabolic process (GO:0006047)3.58097395
14biotin metabolic process (GO:0006768)3.57558264
15cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.54144965
16metanephric mesenchyme development (GO:0072075)3.51825899
17endodermal cell differentiation (GO:0035987)3.50445317
18nuclear pore complex assembly (GO:0051292)3.47927710
19regulation of integrin-mediated signaling pathway (GO:2001044)3.38969487
20wound healing, spreading of epidermal cells (GO:0035313)3.38033739
21skin morphogenesis (GO:0043589)3.37910959
22nuclear pore organization (GO:0006999)3.33862653
23import into cell (GO:0098657)3.33099844
24fibrinolysis (GO:0042730)3.32428884
25positive regulation of macrophage activation (GO:0043032)3.29827190
26regulation of tight junction assembly (GO:2000810)3.26874598
27regulation of chemokine secretion (GO:0090196)3.24982382
28kidney mesenchyme development (GO:0072074)3.21011576
29positive regulation of actin filament depolymerization (GO:0030836)3.19954806
30regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.19412291
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.19253662
32folic acid transport (GO:0015884)3.16315160
33branching involved in prostate gland morphogenesis (GO:0060442)3.13928179
34vascular endothelial growth factor signaling pathway (GO:0038084)3.13536207
35regulation of hippo signaling (GO:0035330)3.11851617
36proteasome assembly (GO:0043248)3.11301399
37L-phenylalanine metabolic process (GO:0006558)3.10032854
38erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.10032854
39regulation of apoptotic process involved in morphogenesis (GO:1902337)3.08862885
40formation of translation preinitiation complex (GO:0001731)3.08177794
41regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.08062623
42peptidyl-proline hydroxylation (GO:0019511)3.08037566
43notochord development (GO:0030903)3.06744206
44protein heterotrimerization (GO:0070208)3.06582104
45cell adhesion mediated by integrin (GO:0033627)3.06321518
46cartilage condensation (GO:0001502)3.04908507
47cell aggregation (GO:0098743)3.04908507
48cellular response to vitamin D (GO:0071305)3.04047405
49copper ion transport (GO:0006825)3.00866396
50cellular response to vitamin (GO:0071295)3.00425799
51paraxial mesoderm development (GO:0048339)2.95903028
52negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.95728697
53regulation of metalloenzyme activity (GO:0048552)2.95100754
54ribosome assembly (GO:0042255)2.93443834
55positive regulation of protein autophosphorylation (GO:0031954)2.92377327
56retinal metabolic process (GO:0042574)2.89045257
57positive regulation of endothelial cell apoptotic process (GO:2000353)2.87234888
58serine family amino acid biosynthetic process (GO:0009070)2.87205196
59outer ear morphogenesis (GO:0042473)2.83250469
60chondrocyte development (GO:0002063)2.82446551
61nucleotide-sugar biosynthetic process (GO:0009226)2.82190594
62wound healing, spreading of cells (GO:0044319)2.81388631
63nucleobase-containing small molecule interconversion (GO:0015949)2.80405656
64positive regulation of osteoblast proliferation (GO:0033690)2.80395477
65heterochromatin organization (GO:0070828)2.80068609
66tetrahydrofolate metabolic process (GO:0046653)2.79565134
67basement membrane organization (GO:0071711)2.79368227
68dermatan sulfate biosynthetic process (GO:0030208)2.79042297
69endothelial cell morphogenesis (GO:0001886)2.78223284
70regulation of gene silencing by RNA (GO:0060966)2.78217177
71regulation of posttranscriptional gene silencing (GO:0060147)2.78217177
72regulation of gene silencing by miRNA (GO:0060964)2.78217177
73polarized epithelial cell differentiation (GO:0030859)2.76841955
74establishment of apical/basal cell polarity (GO:0035089)2.76254225
75alpha-linolenic acid metabolic process (GO:0036109)2.74317251
76epithelial cell-cell adhesion (GO:0090136)2.73451981
77pteridine-containing compound metabolic process (GO:0042558)2.73329239
78proline metabolic process (GO:0006560)2.73021509
79pattern specification involved in kidney development (GO:0061004)2.72969277
80negative regulation of glycogen biosynthetic process (GO:0045719)2.72814020
81very-low-density lipoprotein particle assembly (GO:0034379)2.72420357
82folic acid metabolic process (GO:0046655)2.72199313
83branched-chain amino acid catabolic process (GO:0009083)2.71099273
84type B pancreatic cell proliferation (GO:0044342)2.70459508
85ribosomal large subunit biogenesis (GO:0042273)2.69872749
86NADH metabolic process (GO:0006734)2.69213208
87mitotic nuclear envelope disassembly (GO:0007077)2.69179004
88negative regulation of fibrinolysis (GO:0051918)2.69101527
89protein localization to endosome (GO:0036010)2.68275113
90branching involved in salivary gland morphogenesis (GO:0060445)2.68251218
91folic acid-containing compound metabolic process (GO:0006760)2.66342683
92response to testosterone (GO:0033574)2.66219265
93hippo signaling (GO:0035329)2.64206541
94cellular copper ion homeostasis (GO:0006878)2.64023073
95regulation of fibrinolysis (GO:0051917)2.63610333
96IMP biosynthetic process (GO:0006188)2.63389489
97lens fiber cell development (GO:0070307)2.63022067
98cranial suture morphogenesis (GO:0060363)2.61733369
99protein carboxylation (GO:0018214)2.61126269
100peptidyl-glutamic acid carboxylation (GO:0017187)2.61126269
101membrane raft organization (GO:0031579)2.60105292
102maturation of SSU-rRNA (GO:0030490)2.59357066
103establishment of integrated proviral latency (GO:0075713)2.59261849
104regulation of translational fidelity (GO:0006450)2.56888161
105membrane disassembly (GO:0030397)2.56870183
106nuclear envelope disassembly (GO:0051081)2.56870183
107positive regulation of chemokine secretion (GO:0090197)2.56660243
108histone-serine phosphorylation (GO:0035404)2.56207126
109ribosome biogenesis (GO:0042254)2.55755934
110pore complex assembly (GO:0046931)2.55699444
111regulation of cellular amino acid metabolic process (GO:0006521)2.55511211
112nuclear envelope reassembly (GO:0031468)2.55155342
113mitotic nuclear envelope reassembly (GO:0007084)2.55155342
114retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.54218155
115long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.53941253
116craniofacial suture morphogenesis (GO:0097094)2.53858099
117retina vasculature morphogenesis in camera-type eye (GO:0061299)2.53072581
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52840728
119L-phenylalanine catabolic process (GO:0006559)2.52840728
120vesicle coating (GO:0006901)2.52472012
121regulation of SMAD protein import into nucleus (GO:0060390)2.52412653
122mesenchymal-epithelial cell signaling (GO:0060638)2.52200949
123protein hydroxylation (GO:0018126)2.50764679
124proline biosynthetic process (GO:0006561)2.50695765
125activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.50213392
126negative regulation of chondrocyte differentiation (GO:0032331)2.50157492
127daunorubicin metabolic process (GO:0044597)2.49256873
128polyketide metabolic process (GO:0030638)2.49256873
129doxorubicin metabolic process (GO:0044598)2.49256873
130embryonic skeletal joint morphogenesis (GO:0060272)2.49020749
131hemidesmosome assembly (GO:0031581)2.48675316
132regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.47544972
133negative regulation of glycogen metabolic process (GO:0070874)2.47117876
134negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46746286
135desmosome organization (GO:0002934)2.45176843
136sequestering of extracellular ligand from receptor (GO:0035581)2.45123093
137bile acid biosynthetic process (GO:0006699)2.44804042
138ribonucleoprotein complex biogenesis (GO:0022613)2.44626140
139tricarboxylic acid cycle (GO:0006099)2.44543924
140pteridine-containing compound biosynthetic process (GO:0042559)2.44147468
141protein localization to cell surface (GO:0034394)2.43084472
142positive regulation of nuclease activity (GO:0032075)2.43041214
143anterior/posterior axis specification, embryo (GO:0008595)2.42805954
144tooth mineralization (GO:0034505)2.42679545
145regulation of mitotic spindle organization (GO:0060236)2.42624231
146SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.41704484
147tRNA aminoacylation for protein translation (GO:0006418)2.40832776
148collagen metabolic process (GO:0032963)2.40733642
149L-serine metabolic process (GO:0006563)2.39504486
150regulation of protein heterodimerization activity (GO:0043497)2.38629638
151COPII vesicle coating (GO:0048208)2.38486287
152dermatan sulfate metabolic process (GO:0030205)2.38052334
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.37895161
154bone trabecula formation (GO:0060346)2.37353805
155dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.37293982
156endothelial cell chemotaxis (GO:0035767)2.36724243
157endoplasmic reticulum unfolded protein response (GO:0030968)2.36077903
158protein N-linked glycosylation (GO:0006487)2.34476171
159muscle cell migration (GO:0014812)2.33748674
160protein autoprocessing (GO:0016540)2.33423015
161protein N-linked glycosylation via asparagine (GO:0018279)2.33297153
162zinc ion transmembrane transport (GO:0071577)2.32966880
163establishment of viral latency (GO:0019043)2.32939328
164negative regulation of coagulation (GO:0050819)2.31553018
165negative regulation of ligase activity (GO:0051352)2.31305699
166negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.31305699
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.30405277
168peptidyl-asparagine modification (GO:0018196)2.29380306
169cell redox homeostasis (GO:0045454)2.28982489
170fatty-acyl-CoA biosynthetic process (GO:0046949)2.28454093
171beta-amyloid metabolic process (GO:0050435)2.26909144
1724-hydroxyproline metabolic process (GO:0019471)2.25809810
173ER overload response (GO:0006983)2.25268798
174membrane budding (GO:0006900)2.23974020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.45887072
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.68370152
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.88219128
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.87230941
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.65805229
6E2F7_22180533_ChIP-Seq_HELA_Human3.54334373
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.97373229
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92555558
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.91848357
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.81802896
11ZNF263_19887448_ChIP-Seq_K562_Human2.81483934
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.74098209
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.59577858
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.55932029
15CLOCK_20551151_ChIP-Seq_293T_Human2.48918521
16AR_21909140_ChIP-Seq_LNCAP_Human2.46121199
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37720037
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27011751
19* CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.23252637
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20896124
21HIF1A_21447827_ChIP-Seq_MCF-7_Human2.20510630
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19493971
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18226443
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17799274
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17583506
26RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.16677126
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.14619848
28RXR_22158963_ChIP-Seq_LIVER_Mouse2.12508248
29ELK1_22589737_ChIP-Seq_MCF10A_Human2.06707700
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05753472
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.01597434
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95522517
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95284419
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.88293207
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.87497783
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.86691372
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.84083328
38PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82051288
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81984969
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80320320
41SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80320320
42ATF3_27146783_Chip-Seq_COLON_Human1.79674233
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78298095
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.78150472
45DCP1A_22483619_ChIP-Seq_HELA_Human1.76572393
46* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.76155920
47XRN2_22483619_ChIP-Seq_HELA_Human1.73748271
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.67433252
49ELK1_19687146_ChIP-ChIP_HELA_Human1.65657545
50HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.65498908
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62725662
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.59329974
53ESR1_15608294_ChIP-ChIP_MCF-7_Human1.58635088
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57969244
55NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.56310886
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54903562
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.54417991
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.51372918
59* BRD4_25478319_ChIP-Seq_HGPS_Human1.50929993
60FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.47977913
61LXR_22158963_ChIP-Seq_LIVER_Mouse1.47705476
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47584264
63ETS1_20019798_ChIP-Seq_JURKAT_Human1.47198484
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44507153
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44369003
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44268474
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43123468
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.42766923
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42615067
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41089526
71CJUN_26792858_Chip-Seq_BT549_Human1.40761197
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.39958838
73EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39807015
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.39219408
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.38172691
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35380972
77CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.30268397
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29182974
79SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29117708
80TFEB_21752829_ChIP-Seq_HELA_Human1.28291285
81SOX17_20123909_ChIP-Seq_XEN_Mouse1.28208646
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27603993
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25943281
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.24544949
85EOMES_21245162_ChIP-Seq_HESCs_Human1.23332399
86KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.22330850
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.22330850
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.22330850
89* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21527698
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21451002
91GATA6_25053715_ChIP-Seq_YYC3_Human1.19528243
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.19290758
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.18512422
94GABP_19822575_ChIP-Seq_HepG2_Human1.18253675
95NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17917435
96ELF5_23300383_ChIP-Seq_T47D_Human1.17010534
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.16424030
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.16237880
99PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16124160
100* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14774209
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14656868
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13834531
103TTF2_22483619_ChIP-Seq_HELA_Human1.13475014
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.12061766
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11540069
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10992400
107SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10485354
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10466661
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08418568
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08082571
111* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07103673
112SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07095934
113* SOX2_20726797_ChIP-Seq_SW620_Human1.06977448
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.05809699
115GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05635537
116ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05466865
117SALL1_21062744_ChIP-ChIP_HESCs_Human1.04343333
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03405545
119PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02603279
120KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01783137
121UBF1/2_26484160_Chip-Seq_HMECs_Human1.00492808
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.00482596
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00354305
124NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00240354
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.99880189
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99753578
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99440857
128POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99238372
129GATA2_21666600_ChIP-Seq_HMVEC_Human0.99170212
130* CHD1_26751641_Chip-Seq_LNCaP_Human0.98591704
131FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98059301
132TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97813267
133FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97728090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.03352256
2MP0003705_abnormal_hypodermis_morpholog4.07245921
3MP0003279_aneurysm3.39911536
4MP0005503_abnormal_tendon_morphology3.38051461
5MP0010030_abnormal_orbit_morphology3.14418106
6MP0004858_abnormal_nervous_system2.99841888
7MP0010352_gastrointestinal_tract_polyps2.88883703
8MP0005275_abnormal_skin_tensile2.86245823
9MP0009384_cardiac_valve_regurgitation2.83481384
10MP0001958_emphysema2.68032196
11MP0005360_urolithiasis2.59639139
12MP0003191_abnormal_cellular_cholesterol2.49849676
13MP0005023_abnormal_wound_healing2.40950090
14MP0003566_abnormal_cell_adhesion2.38211051
15MP0002877_abnormal_melanocyte_morpholog2.31734487
16MP0003011_delayed_dark_adaptation2.27600395
17MP0009780_abnormal_chondrocyte_physiolo2.17343780
18MP0009697_abnormal_copulation2.12722683
19MP0004272_abnormal_basement_membrane2.12537773
20MP0010234_abnormal_vibrissa_follicle2.03369768
21MP0005623_abnormal_meninges_morphology2.03105273
22MP0008004_abnormal_stomach_pH1.98142901
23MP0009250_abnormal_appendicular_skeleto1.92906655
24MP0009053_abnormal_anal_canal1.92566238
25MP0001299_abnormal_eye_distance/1.87573213
26MP0003091_abnormal_cell_migration1.85379314
27MP0005508_abnormal_skeleton_morphology1.84769823
28MP0003806_abnormal_nucleotide_metabolis1.76025427
29MP0003868_abnormal_feces_composition1.72572071
30MP0002166_altered_tumor_susceptibility1.65083327
31MP0003315_abnormal_perineum_morphology1.64888897
32MP0003941_abnormal_skin_development1.62276492
33MP0010368_abnormal_lymphatic_system1.59552099
34MP0008932_abnormal_embryonic_tissue1.58957183
35MP0001542_abnormal_bone_strength1.58471712
36MP0003123_paternal_imprinting1.57723451
37MP0005365_abnormal_bile_salt1.57173268
38MP0002896_abnormal_bone_mineralization1.56889343
39MP0002060_abnormal_skin_morphology1.55203265
40MP0009840_abnormal_foam_cell1.54961375
41MP0002139_abnormal_hepatobiliary_system1.54103505
42MP0003950_abnormal_plasma_membrane1.53190165
43MP0000537_abnormal_urethra_morphology1.51644566
44MP0002876_abnormal_thyroid_physiology1.50100935
45MP0000163_abnormal_cartilage_morphology1.49124526
46MP0004233_abnormal_muscle_weight1.48535070
47MP0004957_abnormal_blastocyst_morpholog1.47956269
48MP0000733_abnormal_muscle_development1.44486536
49MP0005670_abnormal_white_adipose1.41923487
50MP0005257_abnormal_intraocular_pressure1.41445308
51MP0002006_tumorigenesis1.40609012
52MP0002282_abnormal_trachea_morphology1.39775422
53MP0000750_abnormal_muscle_regeneration1.38966662
54MP0004134_abnormal_chest_morphology1.38558006
55MP0006054_spinal_hemorrhage1.38486626
56MP0003942_abnormal_urinary_system1.37466513
57MP0002295_abnormal_pulmonary_circulatio1.36854713
58MP0003755_abnormal_palate_morphology1.35697291
59MP0003693_abnormal_embryo_hatching1.33104411
60MP0003300_gastrointestinal_ulcer1.29071931
61MP0003937_abnormal_limbs/digits/tail_de1.28511337
62MP0005451_abnormal_body_composition1.26057332
63MP0008007_abnormal_cellular_replicative1.24978433
64MP0004133_heterotaxia1.24560164
65MP0000762_abnormal_tongue_morphology1.22396718
66MP0003385_abnormal_body_wall1.22114138
67MP0005085_abnormal_gallbladder_physiolo1.21499953
68MP0002115_abnormal_skeleton_extremities1.20621938
69MP0005647_abnormal_sex_gland1.17775358
70MP0000534_abnormal_ureter_morphology1.17741035
71MP0002111_abnormal_tail_morphology1.17728137
72MP0001243_abnormal_dermal_layer1.15234519
73MP0002113_abnormal_skeleton_development1.14994317
74MP0000751_myopathy1.11937905
75MP0004197_abnormal_fetal_growth/weight/1.11535323
76MP0001666_abnormal_nutrient_absorption1.10622416
77MP0001881_abnormal_mammary_gland1.10373398
78MP0005076_abnormal_cell_differentiation1.08797284
79MP0005164_abnormal_response_to1.08595622
80MP0000428_abnormal_craniofacial_morphol1.07522297
81MP0001879_abnormal_lymphatic_vessel1.07315439
82MP0003718_maternal_effect1.06863908
83MP0002089_abnormal_postnatal_growth/wei1.06594032
84MP0002233_abnormal_nose_morphology1.06559488
85MP0000432_abnormal_head_morphology1.06021396
86MP0002933_joint_inflammation1.05341562
87MP0000350_abnormal_cell_proliferation1.03751191
88MP0003283_abnormal_digestive_organ1.03589026
89MP0002796_impaired_skin_barrier1.02451818
90MP0003077_abnormal_cell_cycle1.02149952
91MP0000049_abnormal_middle_ear1.01144709
92MP0000613_abnormal_salivary_gland1.00768192
93MP0005390_skeleton_phenotype0.97635191
94MP0008875_abnormal_xenobiotic_pharmacok0.96610362
95MP0001764_abnormal_homeostasis0.95302886
96MP0000013_abnormal_adipose_tissue0.94173615
97MP0002108_abnormal_muscle_morphology0.93667528
98MP0005395_other_phenotype0.92487595
99MP0005165_increased_susceptibility_to0.91612233
100MP0005332_abnormal_amino_acid0.90218801
101MP0003115_abnormal_respiratory_system0.89306482
102MP0000627_abnormal_mammary_gland0.87932343
103MP0000858_altered_metastatic_potential0.86286550
104MP0002116_abnormal_craniofacial_bone0.85992901
105MP0003111_abnormal_nucleus_morphology0.85200409
106MP0001730_embryonic_growth_arrest0.84828217
107MP0002085_abnormal_embryonic_tissue0.84733196
108MP0005666_abnormal_adipose_tissue0.84260957
109MP0002084_abnormal_developmental_patter0.83540222
110MP0005220_abnormal_exocrine_pancreas0.82892491
111MP0005501_abnormal_skin_physiology0.82148558
112MP0002234_abnormal_pharynx_morphology0.82058000
113MP0003935_abnormal_craniofacial_develop0.81928918
114MP0001661_extended_life_span0.81148138
115MP0002168_other_aberrant_phenotype0.81072356
116MP0003936_abnormal_reproductive_system0.80841718
117MP0003075_altered_response_to0.80476401
118MP0002109_abnormal_limb_morphology0.79582919
119MP0001216_abnormal_epidermal_layer0.79267695
120MP0001915_intracranial_hemorrhage0.78382208
121MP0005380_embryogenesis_phenotype0.78216396
122MP0001672_abnormal_embryogenesis/_devel0.78216396
123MP0010329_abnormal_lipoprotein_level0.78207761
124MP0003984_embryonic_growth_retardation0.77976670
125MP0001697_abnormal_embryo_size0.77670381
126MP0010307_abnormal_tumor_latency0.77170097
127MP0004185_abnormal_adipocyte_glucose0.77032705
128MP0005408_hypopigmentation0.76528085
129MP0001853_heart_inflammation0.76394741
130MP0003453_abnormal_keratinocyte_physiol0.76160297
131MP0000678_abnormal_parathyroid_gland0.76076364
132MP0003795_abnormal_bone_structure0.75463091
133MP0003186_abnormal_redox_activity0.75191293
134MP0002088_abnormal_embryonic_growth/wei0.74895845
135MP0005197_abnormal_uvea_morphology0.73627899
136MP0002932_abnormal_joint_morphology0.73222384
137MP0005330_cardiomyopathy0.72384288
138MP0000767_abnormal_smooth_muscle0.71154833
139MP0008789_abnormal_olfactory_epithelium0.70637432
140MP0004019_abnormal_vitamin_homeostasis0.68878462
141MP0000538_abnormal_urinary_bladder0.67379131
142MP0000747_muscle_weakness0.65111398
143MP0000609_abnormal_liver_physiology0.64817445
144MP0005636_abnormal_mineral_homeostasis0.64213658
145MP0002090_abnormal_vision0.63785514
146MP0003252_abnormal_bile_duct0.62507227
147MP0005058_abnormal_lysosome_morphology0.61569572

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.79866075
2Protrusio acetabuli (HP:0003179)5.74900293
3Intrahepatic cholestasis (HP:0001406)4.12333519
4Neonatal short-limb short stature (HP:0008921)3.92308403
5Epiphyseal dysplasia (HP:0002656)3.88421681
6Soft skin (HP:0000977)3.64217901
7Irregular epiphyses (HP:0010582)3.61650144
8Cervical subluxation (HP:0003308)3.43672938
9Atrophic scars (HP:0001075)3.37929491
10Ankle contracture (HP:0006466)3.35839796
11Cupped ribs (HP:0000887)3.29617757
12Abnormality of glycolysis (HP:0004366)3.16745628
13Deep venous thrombosis (HP:0002625)3.13288640
14Increased serum pyruvate (HP:0003542)3.04577628
15Abnormality of dentin (HP:0010299)3.04530062
16Abnormality of the proximal phalanges of the hand (HP:0009834)2.97459273
17Wormian bones (HP:0002645)2.97195314
18Abnormality of monocarboxylic acid metabolism (HP:0010996)2.93607143
19Reduced subcutaneous adipose tissue (HP:0003758)2.93418690
20Flat acetabular roof (HP:0003180)2.91384729
21Cardiovascular calcification (HP:0011915)2.90548760
22Vertebral compression fractures (HP:0002953)2.89819325
23Coxa vara (HP:0002812)2.89144372
24Vitreoretinal degeneration (HP:0000655)2.86910231
25Abnormality of the ischium (HP:0003174)2.86037805
26Hypoplastic ischia (HP:0003175)2.85035159
27Sparse lateral eyebrow (HP:0005338)2.83102874
28Delayed epiphyseal ossification (HP:0002663)2.82328662
29Mild short stature (HP:0003502)2.80550368
30Mesomelia (HP:0003027)2.79350802
31Abnormality of aromatic amino acid family metabolism (HP:0004338)2.79055032
32Spinal rigidity (HP:0003306)2.78745531
33Abnormality of carpal bone ossification (HP:0006257)2.75544437
34Peritonitis (HP:0002586)2.72722325
35Fat malabsorption (HP:0002630)2.72211831
36Short nail (HP:0001799)2.72002695
37Abnormality of the distal phalanges of the toes (HP:0010182)2.69418318
38Aortic dissection (HP:0002647)2.68732508
39Aortic aneurysm (HP:0004942)2.66539471
40Testicular atrophy (HP:0000029)2.65306982
41Vascular calcification (HP:0004934)2.64587282
42Hypobetalipoproteinemia (HP:0003563)2.62736005
43Reduced antithrombin III activity (HP:0001976)2.61771011
44Hypolipoproteinemia (HP:0010981)2.61335430
45Shallow orbits (HP:0000586)2.61217121
46Right ventricular cardiomyopathy (HP:0011663)2.58385780
47Genu varum (HP:0002970)2.58335681
48Spinal cord compression (HP:0002176)2.57513878
49Hypoalphalipoproteinemia (HP:0003233)2.56558051
50Abnormality of the intrinsic pathway (HP:0010989)2.56294648
51Biconcave vertebral bodies (HP:0004586)2.55765336
52Increased connective tissue (HP:0009025)2.55049885
53Fragile skin (HP:0001030)2.54599192
54Dilatation of the ascending aorta (HP:0005111)2.51026975
55Metaphyseal cupping (HP:0003021)2.49902717
56Abnormality of the calcaneus (HP:0008364)2.49813528
57Small epiphyses (HP:0010585)2.47382475
58Genu recurvatum (HP:0002816)2.45851117
59Cerebral aneurysm (HP:0004944)2.45266464
60Ulnar bowing (HP:0003031)2.44326043
61Abnormality of the acetabulum (HP:0003170)2.42769465
62Stillbirth (HP:0003826)2.42193987
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.39796502
64Follicular hyperkeratosis (HP:0007502)2.38923631
65Glucose intolerance (HP:0000833)2.36566675
66Abnormality of the 2nd finger (HP:0004100)2.36140263
67Beaking of vertebral bodies (HP:0004568)2.36007694
68Flat capital femoral epiphysis (HP:0003370)2.35782121
69Platyspondyly (HP:0000926)2.34018267
70Prolonged partial thromboplastin time (HP:0003645)2.33680900
71Radial bowing (HP:0002986)2.32736698
72Delayed closure of the anterior fontanelle (HP:0001476)2.32440351
73Blue sclerae (HP:0000592)2.32070390
74Abnormality of the common coagulation pathway (HP:0010990)2.30569186
75Osteoarthritis (HP:0002758)2.27507900
76Conjugated hyperbilirubinemia (HP:0002908)2.26924184
77Delayed cranial suture closure (HP:0000270)2.24411290
78Microglossia (HP:0000171)2.20980620
79Fibular aplasia (HP:0002990)2.20581391
80Trismus (HP:0000211)2.18995773
81Vascular tortuosity (HP:0004948)2.18811837
82Thoracolumbar scoliosis (HP:0002944)2.18504505
83Wrist flexion contracture (HP:0001239)2.15660336
84Elbow flexion contracture (HP:0002987)2.13633810
85Distal lower limb muscle weakness (HP:0009053)2.13134729
86Aplasia involving bones of the extremities (HP:0009825)2.11886220
87Aplasia involving bones of the upper limbs (HP:0009823)2.11886220
88Aplasia of the phalanges of the hand (HP:0009802)2.11886220
89Persistence of primary teeth (HP:0006335)2.11751185
90Abnormal tarsal ossification (HP:0008369)2.11329619
91Generalized amyotrophy (HP:0003700)2.10315455
92Steatorrhea (HP:0002570)2.10181580
93Abnormal foot bone ossification (HP:0010675)2.09975198
94Abnormal hemoglobin (HP:0011902)2.09618431
95Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08730253
96Skin nodule (HP:0200036)2.07281106
97Selective tooth agenesis (HP:0001592)2.06046820
98Increased density of long bones (HP:0006392)2.05529094
99Advanced eruption of teeth (HP:0006288)2.05483801
100Abnormal hand bone ossification (HP:0010660)2.04565688
101Redundant skin (HP:0001582)2.02516813
102Synostosis of carpal bones (HP:0005048)2.02386830
103Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.02261571
104Bladder diverticulum (HP:0000015)2.02178956
105Abnormality of the umbilical cord (HP:0010881)2.01451704
106Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.01278607
107Flattened epiphyses (HP:0003071)2.01252657
108Myocardial infarction (HP:0001658)2.01148979
109Osteolytic defects of the phalanges of the hand (HP:0009771)2.00671646
110Osteolytic defects of the hand bones (HP:0009699)2.00671646
111Scapular winging (HP:0003691)2.00609132
112Overgrowth (HP:0001548)2.00245016
113Abnormality of methionine metabolism (HP:0010901)1.98630426
114Glossoptosis (HP:0000162)1.98332095
115Natal tooth (HP:0000695)1.98276270
116Broad long bones (HP:0005622)1.97188494
117Aplasia/Hypoplasia of the scapulae (HP:0006713)1.94619409
118Hypoplastic scapulae (HP:0000882)1.94619409
119Hand muscle atrophy (HP:0009130)1.94324753
120Abnormalities of placenta or umbilical cord (HP:0001194)1.93794728
121Limited elbow extension (HP:0001377)1.93779745
122Arterial tortuosity (HP:0005116)1.92634629
123Abnormal vertebral ossification (HP:0100569)1.91500769
124Distal upper limb amyotrophy (HP:0007149)1.91324220
125Upper limb amyotrophy (HP:0009129)1.91324220
126Abnormal ossification of hand bones (HP:0005921)1.90236523
127Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89957465
128Abnormal delivery (HP:0001787)1.89050287
129Vertebral hypoplasia (HP:0008417)1.87810159
130Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.87810159
131Prolonged neonatal jaundice (HP:0006579)1.87583556
132Abnormality of the frontal sinuses (HP:0002687)1.87153246
133Spontaneous abortion (HP:0005268)1.86727644
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.85851183
135Delayed CNS myelination (HP:0002188)1.84974313
136Femoral bowing (HP:0002980)1.84158019
137Tibial bowing (HP:0002982)1.83962198
138Cholecystitis (HP:0001082)1.83682301
139Abnormal gallbladder physiology (HP:0012438)1.83682301
140Bowing of the arm (HP:0006488)1.83563557
141Bowed forearm bones (HP:0003956)1.83563557
142Thin ribs (HP:0000883)1.83440231
143Broad metatarsal (HP:0001783)1.82907718
144Abnormal cartilage morphology (HP:0002763)1.81944791
145Long palpebral fissure (HP:0000637)1.80810929
146Sparse eyelashes (HP:0000653)1.80757315
147Coronal craniosynostosis (HP:0004440)1.78813408
148Hyperammonemia (HP:0001987)1.75159715
149Rough bone trabeculation (HP:0100670)1.74565658
150Hyperextensible skin (HP:0000974)1.71799500
151Type I transferrin isoform profile (HP:0003642)1.71362230
152Protruding ear (HP:0000411)1.69199076
153Hypercholesterolemia (HP:0003124)1.68637271
154Acute encephalopathy (HP:0006846)1.66701175
155Azoospermia (HP:0000027)1.66473686
156Pterygium (HP:0001059)1.66201218
157Prostate neoplasm (HP:0100787)1.65634607
158Joint hemorrhage (HP:0005261)1.65509239
159Aplasia of the musculature (HP:0100854)1.65483177
160Abnormality of complement system (HP:0005339)1.64193267
161Spondylolisthesis (HP:0003302)1.63336596
162Abnormality of the Achilles tendon (HP:0005109)1.63153305
163Abnormality of the phalanges of the hallux (HP:0010057)1.62275081
164Short clavicles (HP:0000894)1.61948487
165Thin skin (HP:0000963)1.61856892
166Ankyloglossia (HP:0010296)1.61469477
167Slender build (HP:0001533)1.60112271

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.18991738
2PRKD34.05084555
3MST1R3.81958915
4DDR23.64260904
5AKT33.48881823
6TESK13.34497974
7TTN2.83510715
8VRK22.65634378
9LIMK12.58815949
10NME22.58031360
11LATS22.54307930
12CAMK1D2.28643685
13BUB12.22377852
14TRIB32.09754806
15STK38L2.08474864
16TESK22.07368710
17TRPM71.89860408
18MAP3K31.81212471
19IRAK31.80948250
20RPS6KB21.78624416
21MST41.75023520
22EIF2AK11.73562517
23TAF11.71660299
24ARAF1.71238195
25RPS6KA41.69040590
26MET1.66251833
27MYLK1.64920048
28PDGFRA1.63597850
29ERBB31.62567902
30CAMK1G1.61080480
31MAP3K121.60570389
32PAK21.58592161
33PAK41.56343240
34PRKG21.52776415
35MOS1.48104230
36PTK21.46483012
37FRK1.42100753
38STK101.40732816
39TGFBR21.38141813
40PKN21.34738625
41FER1.30318730
42SCYL21.29008151
43PBK1.27885039
44CDC71.27665719
45LATS11.27157813
46LRRK21.26932641
47GRK11.24049538
48TTK1.23223235
49STK391.22765143
50BMX1.18552763
51BRSK11.18315496
52PAK31.16638828
53MAP3K81.16468414
54EIF2AK31.16302782
55WEE11.14840148
56PRKD21.14312434
57ZAK1.12964060
58PIM21.11143014
59TLK11.10973558
60AURKB1.07584599
61BRSK21.04355064
62PLK31.04293180
63LMTK21.04093778
64SMG11.04029506
65STK31.03285437
66PAK10.99903786
67STK160.99518492
68SIK10.99151586
69MKNK10.98166099
70MAPKAPK30.97407985
71PIK3CA0.96997107
72ICK0.96179939
73PLK10.96112248
74PDK20.95131607
75EPHB20.94282088
76NEK10.93925599
77PTK60.89221005
78AURKA0.86581081
79PIK3CG0.82389909
80ROCK10.81450239
81FGFR10.81157366
82EEF2K0.80514855
83FLT30.79129765
84PASK0.73996130
85ERN10.73430677
86CDK70.71849941
87MTOR0.71283765
88ERBB40.69040743
89PRKCI0.67860262
90SRPK10.66142980
91ILK0.65910645
92MAP2K10.64937853
93CDK80.63913912
94ALK0.63342647
95TNK20.63195570
96PDK40.62137648
97PDK30.62137648
98NEK90.62089901
99DAPK10.60698972
100BRAF0.58277822
101NME10.58223778
102EPHA30.56912388
103NEK20.56884303
104CHEK20.55740241
105CDK120.55511793
106CDK60.53963356
107ROCK20.50506824
108TAOK20.47244918
109INSR0.46920385
110NUAK10.46461828
111ABL20.46319211
112PDGFRB0.45719290
113TSSK60.44700403
114CDK140.39992330
115MAPKAPK20.39709875
116VRK10.39168995
117MELK0.38722597
118CHEK10.37656450
119MAP3K110.37359460
120RAF10.37002718
121PTK2B0.36856895
122EIF2AK20.36359222
123DAPK30.36225042
124GSK3A0.36193437
125CDK90.35734835
126TGFBR10.34966504
127PRKAA20.34585030
128PLK20.33930517
129EPHB10.33632099
130CDK150.33001611
131CAMKK20.32920765
132STK40.32858511
133ATR0.32819707
134PRKCE0.31585843
135GRK50.30131234
136CSNK2A20.25929734
137WNK40.22303738

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.39649109
2ECM-receptor interaction_Homo sapiens_hsa045123.36476545
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97857844
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.94991249
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.76591734
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.67954589
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.66601670
8Ribosome_Homo sapiens_hsa030102.58275099
9RNA transport_Homo sapiens_hsa030132.40618842
10Proteasome_Homo sapiens_hsa030502.26343558
11Pyruvate metabolism_Homo sapiens_hsa006202.21401347
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.19452530
13Focal adhesion_Homo sapiens_hsa045102.13464992
14Phenylalanine metabolism_Homo sapiens_hsa003602.02839111
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.99452783
16Protein export_Homo sapiens_hsa030601.95616331
17Vitamin B6 metabolism_Homo sapiens_hsa007501.95041618
18Bladder cancer_Homo sapiens_hsa052191.91258912
19p53 signaling pathway_Homo sapiens_hsa041151.85330736
20RNA polymerase_Homo sapiens_hsa030201.84060535
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83638580
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78335276
23Hippo signaling pathway_Homo sapiens_hsa043901.75401501
24Fatty acid elongation_Homo sapiens_hsa000621.74251697
25Proteoglycans in cancer_Homo sapiens_hsa052051.73852510
26Cell cycle_Homo sapiens_hsa041101.73232166
27Complement and coagulation cascades_Homo sapiens_hsa046101.72662286
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71429748
29Propanoate metabolism_Homo sapiens_hsa006401.71376539
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70614633
31Adherens junction_Homo sapiens_hsa045201.69259678
32Protein digestion and absorption_Homo sapiens_hsa049741.68867269
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66770225
34Vitamin digestion and absorption_Homo sapiens_hsa049771.65651162
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.63929470
36Small cell lung cancer_Homo sapiens_hsa052221.61053170
37Spliceosome_Homo sapiens_hsa030401.60459758
38Fatty acid metabolism_Homo sapiens_hsa012121.55938395
39MicroRNAs in cancer_Homo sapiens_hsa052061.52277119
40Arginine biosynthesis_Homo sapiens_hsa002201.51282403
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.50974364
42TGF-beta signaling pathway_Homo sapiens_hsa043501.50141848
43DNA replication_Homo sapiens_hsa030301.47890732
44Glutathione metabolism_Homo sapiens_hsa004801.46816071
45Fatty acid degradation_Homo sapiens_hsa000711.42056292
46Melanoma_Homo sapiens_hsa052181.41023118
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36195414
48PI3K-Akt signaling pathway_Homo sapiens_hsa041511.34820769
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31378766
50Nucleotide excision repair_Homo sapiens_hsa034201.29942940
51Fructose and mannose metabolism_Homo sapiens_hsa000511.26779188
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25781875
53PPAR signaling pathway_Homo sapiens_hsa033201.25082467
54Pyrimidine metabolism_Homo sapiens_hsa002401.22496943
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22481983
56N-Glycan biosynthesis_Homo sapiens_hsa005101.21393566
57Tyrosine metabolism_Homo sapiens_hsa003501.21007131
58Tight junction_Homo sapiens_hsa045301.20248819
59Malaria_Homo sapiens_hsa051441.16217786
60Sulfur metabolism_Homo sapiens_hsa009201.15340710
61Peroxisome_Homo sapiens_hsa041461.14334931
62Retinol metabolism_Homo sapiens_hsa008301.14234204
63Histidine metabolism_Homo sapiens_hsa003401.13523158
64Steroid biosynthesis_Homo sapiens_hsa001001.11588171
65Steroid hormone biosynthesis_Homo sapiens_hsa001401.09778415
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08809196
67Mismatch repair_Homo sapiens_hsa034301.07020401
68Tryptophan metabolism_Homo sapiens_hsa003801.05946991
69Viral carcinogenesis_Homo sapiens_hsa052031.03083906
70Basal cell carcinoma_Homo sapiens_hsa052171.02496598
71Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01395017
72Non-homologous end-joining_Homo sapiens_hsa034501.00686246
73Shigellosis_Homo sapiens_hsa051310.99385870
74beta-Alanine metabolism_Homo sapiens_hsa004100.99241510
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97634414
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97104529
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96831646
78Galactose metabolism_Homo sapiens_hsa000520.96276991
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95814997
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95700244
81Selenocompound metabolism_Homo sapiens_hsa004500.94434642
82Renin-angiotensin system_Homo sapiens_hsa046140.93942309
83Vibrio cholerae infection_Homo sapiens_hsa051100.93307489
84HTLV-I infection_Homo sapiens_hsa051660.91806835
85RNA degradation_Homo sapiens_hsa030180.90190875
86Biosynthesis of amino acids_Homo sapiens_hsa012300.89208311
87Prostate cancer_Homo sapiens_hsa052150.87312468
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84983160
89* Mineral absorption_Homo sapiens_hsa049780.83255385
90Pentose phosphate pathway_Homo sapiens_hsa000300.81846219
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80973752
92Amoebiasis_Homo sapiens_hsa051460.80375619
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78088931
94Sphingolipid metabolism_Homo sapiens_hsa006000.77515777
95Hedgehog signaling pathway_Homo sapiens_hsa043400.77488969
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74740195
97Sulfur relay system_Homo sapiens_hsa041220.74264412
98Fat digestion and absorption_Homo sapiens_hsa049750.73921063
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.71968877
100HIF-1 signaling pathway_Homo sapiens_hsa040660.71476529
101Metabolic pathways_Homo sapiens_hsa011000.71322414
102Other glycan degradation_Homo sapiens_hsa005110.70083784
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.69991801
104Dilated cardiomyopathy_Homo sapiens_hsa054140.69421556
105Fatty acid biosynthesis_Homo sapiens_hsa000610.69324233
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69193736
107Starch and sucrose metabolism_Homo sapiens_hsa005000.68190845
108Legionellosis_Homo sapiens_hsa051340.65157468
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.64488458
110Base excision repair_Homo sapiens_hsa034100.63012621
111Apoptosis_Homo sapiens_hsa042100.62498310
112Homologous recombination_Homo sapiens_hsa034400.62404704
113Arginine and proline metabolism_Homo sapiens_hsa003300.62178504
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.61782717
115Chronic myeloid leukemia_Homo sapiens_hsa052200.60394857
116Epstein-Barr virus infection_Homo sapiens_hsa051690.60074401
117Pathways in cancer_Homo sapiens_hsa052000.59788042
118Systemic lupus erythematosus_Homo sapiens_hsa053220.58136367
119mRNA surveillance pathway_Homo sapiens_hsa030150.56731664
120Thyroid cancer_Homo sapiens_hsa052160.56301813
121Lysine degradation_Homo sapiens_hsa003100.53101755
122Arachidonic acid metabolism_Homo sapiens_hsa005900.52150636
123Phagosome_Homo sapiens_hsa041450.52140903
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51655443
125Prion diseases_Homo sapiens_hsa050200.51307700
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50613426
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50159555
128Purine metabolism_Homo sapiens_hsa002300.49378937
129Rap1 signaling pathway_Homo sapiens_hsa040150.49217023
130Caffeine metabolism_Homo sapiens_hsa002320.48585654
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.48449259
132Carbon metabolism_Homo sapiens_hsa012000.48124925
133Thyroid hormone synthesis_Homo sapiens_hsa049180.47233115
134Basal transcription factors_Homo sapiens_hsa030220.46883367
135Chemical carcinogenesis_Homo sapiens_hsa052040.46034568
136Wnt signaling pathway_Homo sapiens_hsa043100.44967393
137Oxidative phosphorylation_Homo sapiens_hsa001900.44173533
138TNF signaling pathway_Homo sapiens_hsa046680.42402193
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41399315
140Glioma_Homo sapiens_hsa052140.40575469
141Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.37464762
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36623823
143Folate biosynthesis_Homo sapiens_hsa007900.36553257
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35043688
145Parkinsons disease_Homo sapiens_hsa050120.34980554
146Huntingtons disease_Homo sapiens_hsa050160.33899227
147Gap junction_Homo sapiens_hsa045400.33620020
148Butanoate metabolism_Homo sapiens_hsa006500.30843652

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