

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 6.64387246 |
| 2 | ribosome assembly (GO:0042255) | 4.44047219 |
| 3 | DNA replication checkpoint (GO:0000076) | 4.43359566 |
| 4 | mitotic metaphase plate congression (GO:0007080) | 4.38560046 |
| 5 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.29529146 |
| 6 | CENP-A containing nucleosome assembly (GO:0034080) | 4.18576491 |
| 7 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.11233695 |
| 8 | chromatin remodeling at centromere (GO:0031055) | 4.04566971 |
| 9 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 4.04200462 |
| 10 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.02328436 |
| 11 | negative regulation of ligase activity (GO:0051352) | 3.98855967 |
| 12 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.98855967 |
| 13 | purine nucleobase biosynthetic process (GO:0009113) | 3.93084231 |
| 14 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.77840985 |
| 15 | protein maturation by protein folding (GO:0022417) | 3.77250304 |
| 16 | nucleobase biosynthetic process (GO:0046112) | 3.73767030 |
| 17 | metaphase plate congression (GO:0051310) | 3.71812551 |
| 18 | protein neddylation (GO:0045116) | 3.55376921 |
| 19 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.50152805 |
| 20 | protein localization to kinetochore (GO:0034501) | 3.45085111 |
| 21 | histone exchange (GO:0043486) | 3.43305588 |
| 22 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.43207167 |
| 23 | protein-cofactor linkage (GO:0018065) | 3.42638293 |
| 24 | protein deneddylation (GO:0000338) | 3.41978889 |
| 25 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.40812192 |
| 26 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.40812192 |
| 27 | cullin deneddylation (GO:0010388) | 3.40766632 |
| 28 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.40624212 |
| 29 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.40624212 |
| 30 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.40624212 |
| 31 | mitotic sister chromatid segregation (GO:0000070) | 3.38795509 |
| 32 | protein localization to chromosome, centromeric region (GO:0071459) | 3.35607687 |
| 33 | ventricular cardiac muscle cell development (GO:0055015) | 3.34767135 |
| 34 | positive regulation of ligase activity (GO:0051351) | 3.31963841 |
| 35 | kinetochore organization (GO:0051383) | 3.31413947 |
| 36 | chaperone-mediated protein transport (GO:0072321) | 3.31317811 |
| 37 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.28655514 |
| 38 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.28655514 |
| 39 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.27635337 |
| 40 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.24978871 |
| 41 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.24521561 |
| 42 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.21108121 |
| 43 | establishment of chromosome localization (GO:0051303) | 3.18740119 |
| 44 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.15348284 |
| 45 | regulation of metalloenzyme activity (GO:0048552) | 3.13099410 |
| 46 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.12592565 |
| 47 | IMP biosynthetic process (GO:0006188) | 3.11339894 |
| 48 | nucleotide-sugar biosynthetic process (GO:0009226) | 3.10888265 |
| 49 | regulation of ligase activity (GO:0051340) | 3.10686104 |
| 50 | chondrocyte proliferation (GO:0035988) | 3.09756988 |
| 51 | regulation of mitotic spindle organization (GO:0060236) | 3.09663978 |
| 52 | DNA replication-independent nucleosome organization (GO:0034724) | 3.09340521 |
| 53 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.09340521 |
| 54 | mesenchymal-epithelial cell signaling (GO:0060638) | 3.08947041 |
| 55 | cell cycle G1/S phase transition (GO:0044843) | 3.08417472 |
| 56 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.08417472 |
| 57 | regulation of spindle organization (GO:0090224) | 3.07694387 |
| 58 | DNA strand elongation (GO:0022616) | 3.06590219 |
| 59 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.04182645 |
| 60 | maturation of 5.8S rRNA (GO:0000460) | 3.04148877 |
| 61 | mitotic G2/M transition checkpoint (GO:0044818) | 3.01431409 |
| 62 | UDP-N-acetylglucosamine metabolic process (GO:0006047) | 2.99399132 |
| 63 | lymphangiogenesis (GO:0001946) | 2.99021645 |
| 64 | nuclear pore complex assembly (GO:0051292) | 2.97397948 |
| 65 | anterior/posterior axis specification, embryo (GO:0008595) | 2.95296443 |
| 66 | mitotic recombination (GO:0006312) | 2.92990474 |
| 67 | pseudouridine synthesis (GO:0001522) | 2.92037210 |
| 68 | sister chromatid segregation (GO:0000819) | 2.90068633 |
| 69 | kinetochore assembly (GO:0051382) | 2.89107885 |
| 70 | telomere maintenance via recombination (GO:0000722) | 2.87935786 |
| 71 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 2.87611648 |
| 72 | termination of RNA polymerase III transcription (GO:0006386) | 2.87611648 |
| 73 | ribosomal large subunit biogenesis (GO:0042273) | 2.83253197 |
| 74 | peptidyl-histidine modification (GO:0018202) | 2.83236785 |
| 75 | establishment of integrated proviral latency (GO:0075713) | 2.83062279 |
| 76 | protein targeting to mitochondrion (GO:0006626) | 2.78671666 |
| 77 | spindle checkpoint (GO:0031577) | 2.77094317 |
| 78 | rRNA modification (GO:0000154) | 2.76331765 |
| 79 | positive regulation of cell cycle arrest (GO:0071158) | 2.75981027 |
| 80 | DNA double-strand break processing (GO:0000729) | 2.75163359 |
| 81 | regulation of cellular amine metabolic process (GO:0033238) | 2.72933977 |
| 82 | negative regulation of protein ubiquitination (GO:0031397) | 2.72910669 |
| 83 | mitotic nuclear envelope disassembly (GO:0007077) | 2.72566070 |
| 84 | negative regulation of nitric-oxide synthase activity (GO:0051001) | 2.70525270 |
| 85 | mitotic spindle checkpoint (GO:0071174) | 2.69996155 |
| 86 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.67484135 |
| 87 | IMP metabolic process (GO:0046040) | 2.66992952 |
| 88 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.66956142 |
| 89 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 2.65890326 |
| 90 | negative regulation of sister chromatid segregation (GO:0033046) | 2.65890326 |
| 91 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 2.65890326 |
| 92 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 2.65890326 |
| 93 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 2.65890326 |
| 94 | regulation of chromosome segregation (GO:0051983) | 2.64071958 |
| 95 | negative regulation of chromosome segregation (GO:0051985) | 2.62973009 |
| 96 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.62753402 |
| 97 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.62753402 |
| 98 | attachment of spindle microtubules to kinetochore (GO:0008608) | 2.61858297 |
| 99 | nuclear pore organization (GO:0006999) | 2.61499955 |
| 100 | tRNA aminoacylation for protein translation (GO:0006418) | 2.60431440 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.81746741 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.99844957 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.75993286 |
| 4 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.48305834 |
| 5 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.40644257 |
| 6 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.30123705 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.29068054 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.10938403 |
| 9 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.05708746 |
| 10 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.05208034 |
| 11 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 3.02067205 |
| 12 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.93356560 |
| 13 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.76261360 |
| 14 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.69488353 |
| 15 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.62877766 |
| 16 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.58913249 |
| 17 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.46337619 |
| 18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.31110474 |
| 19 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.30018299 |
| 20 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 2.23719062 |
| 21 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.20429990 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.20404052 |
| 23 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.15499777 |
| 24 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.15314743 |
| 25 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.09263336 |
| 26 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.92321857 |
| 27 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.90225930 |
| 28 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.88592386 |
| 29 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.87174784 |
| 30 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.82755858 |
| 31 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.82652524 |
| 32 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.81206932 |
| 33 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.77416428 |
| 34 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.77012266 |
| 35 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.76350510 |
| 36 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.75891455 |
| 37 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.74432415 |
| 38 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.70830829 |
| 39 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.69678861 |
| 40 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.67329563 |
| 41 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.58989702 |
| 42 | BRD4_25478319_ChIP-Seq_HGPS_Human | 1.58420389 |
| 43 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.54376229 |
| 44 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.51414007 |
| 45 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.46966019 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.43994999 |
| 47 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.42800203 |
| 48 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.40179325 |
| 49 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.37883801 |
| 50 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.36935328 |
| 51 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.36821417 |
| 52 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.28208290 |
| 53 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.27818101 |
| 54 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.26934662 |
| 55 | VDR_22108803_ChIP-Seq_LS180_Human | 1.24884210 |
| 56 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.24878456 |
| 57 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.23923929 |
| 58 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.17974751 |
| 59 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.17718280 |
| 60 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 1.14912102 |
| 61 | EOMES_21245162_ChIP-Seq_HESCs_Human | 1.04624319 |
| 62 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.04137411 |
| 63 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.03555110 |
| 64 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.03010586 |
| 65 | EWS_26573619_Chip-Seq_HEK293_Human | 1.02852912 |
| 66 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.02209236 |
| 67 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.01751701 |
| 68 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.01700768 |
| 69 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.01258007 |
| 70 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.01133241 |
| 71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.00444750 |
| 72 | MYC_18940864_ChIP-ChIP_HL60_Human | 0.99944419 |
| 73 | CHD7_19251738_ChIP-ChIP_MESCs_Mouse | 0.96590247 |
| 74 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.96388284 |
| 75 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.95676207 |
| 76 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.94993999 |
| 77 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.93742099 |
| 78 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.92954024 |
| 79 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.91880192 |
| 80 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.91009208 |
| 81 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 0.89644698 |
| 82 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.87317144 |
| 83 | SOX2_19030024_ChIP-ChIP_MESCs_Mouse | 0.86724478 |
| 84 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.86601064 |
| 85 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.85800467 |
| 86 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.84859105 |
| 87 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.83720534 |
| 88 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 0.83030620 |
| 89 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 0.82746165 |
| 90 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.80744817 |
| 91 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 0.79188289 |
| 92 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.79005186 |
| 93 | ZNF274_21170338_ChIP-Seq_K562_Hela | 0.78753957 |
| 94 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.78561528 |
| 95 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.78125208 |
| 96 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.78096053 |
| 97 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 0.77314477 |
| 98 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 0.77314477 |
| 99 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.75057889 |
| 100 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.74191627 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003950_abnormal_plasma_membrane | 3.99811330 |
| 2 | MP0008438_abnormal_cutaneous_collagen | 3.86040680 |
| 3 | MP0004272_abnormal_basement_membrane | 3.41145940 |
| 4 | MP0006054_spinal_hemorrhage | 3.38992256 |
| 5 | MP0010368_abnormal_lymphatic_system | 2.89320892 |
| 6 | MP0004957_abnormal_blastocyst_morpholog | 2.88043271 |
| 7 | MP0009697_abnormal_copulation | 2.86810699 |
| 8 | MP0010094_abnormal_chromosome_stability | 2.85122265 |
| 9 | MP0003806_abnormal_nucleotide_metabolis | 2.70211206 |
| 10 | MP0008057_abnormal_DNA_replication | 2.64588126 |
| 11 | MP0003941_abnormal_skin_development | 2.59950315 |
| 12 | MP0008007_abnormal_cellular_replicative | 2.56272377 |
| 13 | MP0003111_abnormal_nucleus_morphology | 2.54811372 |
| 14 | MP0008932_abnormal_embryonic_tissue | 2.54488882 |
| 15 | MP0003705_abnormal_hypodermis_morpholog | 2.49443554 |
| 16 | MP0003693_abnormal_embryo_hatching | 2.24087550 |
| 17 | MP0008058_abnormal_DNA_repair | 2.21949096 |
| 18 | MP0010030_abnormal_orbit_morphology | 2.18148806 |
| 19 | MP0003786_premature_aging | 2.17502452 |
| 20 | MP0003186_abnormal_redox_activity | 2.13592307 |
| 21 | MP0003077_abnormal_cell_cycle | 2.07607310 |
| 22 | MP0003890_abnormal_embryonic-extraembry | 1.94636744 |
| 23 | MP0010352_gastrointestinal_tract_polyps | 1.86997795 |
| 24 | MP0005623_abnormal_meninges_morphology | 1.80786564 |
| 25 | MP0003566_abnormal_cell_adhesion | 1.79549098 |
| 26 | MP0005275_abnormal_skin_tensile | 1.68391871 |
| 27 | MP0001879_abnormal_lymphatic_vessel | 1.61890695 |
| 28 | MP0003279_aneurysm | 1.57572737 |
| 29 | MP0001730_embryonic_growth_arrest | 1.55808476 |
| 30 | MP0005257_abnormal_intraocular_pressure | 1.53204502 |
| 31 | MP0003718_maternal_effect | 1.50041310 |
| 32 | MP0009250_abnormal_appendicular_skeleto | 1.49047386 |
| 33 | MP0002877_abnormal_melanocyte_morpholog | 1.44938508 |
| 34 | MP0009780_abnormal_chondrocyte_physiolo | 1.41463179 |
| 35 | MP0001542_abnormal_bone_strength | 1.39441272 |
| 36 | MP0008004_abnormal_stomach_pH | 1.36621877 |
| 37 | MP0002084_abnormal_developmental_patter | 1.32164586 |
| 38 | MP0000358_abnormal_cell_content/ | 1.31445755 |
| 39 | MP0001697_abnormal_embryo_size | 1.29187903 |
| 40 | MP0005503_abnormal_tendon_morphology | 1.27714018 |
| 41 | MP0002295_abnormal_pulmonary_circulatio | 1.26132459 |
| 42 | MP0003937_abnormal_limbs/digits/tail_de | 1.25309993 |
| 43 | MP0005380_embryogenesis_phenotype | 1.23623741 |
| 44 | MP0001672_abnormal_embryogenesis/_devel | 1.23623741 |
| 45 | MP0000350_abnormal_cell_proliferation | 1.18329164 |
| 46 | MP0004084_abnormal_cardiac_muscle | 1.16495202 |
| 47 | MP0009053_abnormal_anal_canal | 1.15266737 |
| 48 | MP0000372_irregular_coat_pigmentation | 1.10811851 |
| 49 | MP0005023_abnormal_wound_healing | 1.10728299 |
| 50 | MP0003984_embryonic_growth_retardation | 1.09571180 |
| 51 | MP0002085_abnormal_embryonic_tissue | 1.08475256 |
| 52 | MP0001853_heart_inflammation | 1.07592457 |
| 53 | MP0002088_abnormal_embryonic_growth/wei | 1.05063008 |
| 54 | MP0000049_abnormal_middle_ear | 1.04521280 |
| 55 | MP0001299_abnormal_eye_distance/ | 1.03895717 |
| 56 | MP0000749_muscle_degeneration | 1.03074229 |
| 57 | MP0002060_abnormal_skin_morphology | 1.02626018 |
| 58 | MP0000762_abnormal_tongue_morphology | 1.01954586 |
| 59 | MP0003385_abnormal_body_wall | 1.01360861 |
| 60 | MP0000428_abnormal_craniofacial_morphol | 0.99663294 |
| 61 | MP0002160_abnormal_reproductive_system | 0.99146605 |
| 62 | MP0005408_hypopigmentation | 0.98001758 |
| 63 | MP0002086_abnormal_extraembryonic_tissu | 0.96302908 |
| 64 | MP0002080_prenatal_lethality | 0.96129111 |
| 65 | MP0002102_abnormal_ear_morphology | 0.95255983 |
| 66 | MP0008775_abnormal_heart_ventricle | 0.94635681 |
| 67 | MP0001243_abnormal_dermal_layer | 0.93398696 |
| 68 | MP0006036_abnormal_mitochondrial_physio | 0.92321028 |
| 69 | MP0001881_abnormal_mammary_gland | 0.91096673 |
| 70 | MP0005330_cardiomyopathy | 0.90085375 |
| 71 | MP0006035_abnormal_mitochondrial_morpho | 0.89732069 |
| 72 | MP0005171_absent_coat_pigmentation | 0.87803381 |
| 73 | MP0001293_anophthalmia | 0.87318000 |
| 74 | MP0004147_increased_porphyrin_level | 0.86710338 |
| 75 | MP0002177_abnormal_outer_ear | 0.85326729 |
| 76 | MP0006072_abnormal_retinal_apoptosis | 0.85051293 |
| 77 | MP0002332_abnormal_exercise_endurance | 0.83888059 |
| 78 | MP0002938_white_spotting | 0.82065278 |
| 79 | MP0003935_abnormal_craniofacial_develop | 0.81942270 |
| 80 | MP0003828_pulmonary_edema | 0.81713975 |
| 81 | MP0003755_abnormal_palate_morphology | 0.81558616 |
| 82 | MP0003119_abnormal_digestive_system | 0.78586182 |
| 83 | MP0004215_abnormal_myocardial_fiber | 0.77674482 |
| 84 | MP0000432_abnormal_head_morphology | 0.77116412 |
| 85 | MP0002282_abnormal_trachea_morphology | 0.77018945 |
| 86 | MP0005360_urolithiasis | 0.76230383 |
| 87 | MP0006138_congestive_heart_failure | 0.76149244 |
| 88 | MP0005395_other_phenotype | 0.75583742 |
| 89 | MP0001915_intracranial_hemorrhage | 0.73366367 |
| 90 | MP0001529_abnormal_vocalization | 0.72721205 |
| 91 | MP0000767_abnormal_smooth_muscle | 0.72298360 |
| 92 | MP0006292_abnormal_olfactory_placode | 0.70989434 |
| 93 | MP0002233_abnormal_nose_morphology | 0.69077110 |
| 94 | MP0009384_cardiac_valve_regurgitation | 0.66756684 |
| 95 | MP0008877_abnormal_DNA_methylation | 0.66383574 |
| 96 | MP0001764_abnormal_homeostasis | 0.66097016 |
| 97 | MP0005165_increased_susceptibility_to | 0.65986356 |
| 98 | MP0005197_abnormal_uvea_morphology | 0.65187125 |
| 99 | MP0000647_abnormal_sebaceous_gland | 0.64996188 |
| 100 | MP0002210_abnormal_sex_determination | 0.64856320 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Premature rupture of membranes (HP:0001788) | 4.53843736 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 3.54597223 |
| 3 | Abnormality of the fetal cardiovascular system (HP:0010948) | 3.50293092 |
| 4 | Abnormal umbilical cord blood vessels (HP:0011403) | 3.50293092 |
| 5 | Single umbilical artery (HP:0001195) | 3.50293092 |
| 6 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.26494593 |
| 7 | Acute encephalopathy (HP:0006846) | 3.23346695 |
| 8 | Reduced subcutaneous adipose tissue (HP:0003758) | 3.13657837 |
| 9 | Abnormality of the umbilical cord (HP:0010881) | 2.91383423 |
| 10 | Microglossia (HP:0000171) | 2.85774150 |
| 11 | Progressive macrocephaly (HP:0004481) | 2.82013867 |
| 12 | Ankle contracture (HP:0006466) | 2.76552938 |
| 13 | Nonimmune hydrops fetalis (HP:0001790) | 2.76549304 |
| 14 | Type I transferrin isoform profile (HP:0003642) | 2.72382392 |
| 15 | Follicular hyperkeratosis (HP:0007502) | 2.71219361 |
| 16 | Short middle phalanx of the 5th finger (HP:0004220) | 2.66803363 |
| 17 | Increased serum pyruvate (HP:0003542) | 2.60540641 |
| 18 | Abnormal auditory evoked potentials (HP:0006958) | 2.56508496 |
| 19 | Meckel diverticulum (HP:0002245) | 2.54025340 |
| 20 | Coronal craniosynostosis (HP:0004440) | 2.53304870 |
| 21 | Ankyloglossia (HP:0010296) | 2.51508383 |
| 22 | Hypoplastic pelvis (HP:0008839) | 2.47007301 |
| 23 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.46556838 |
| 24 | Metaphyseal dysplasia (HP:0100255) | 2.44499767 |
| 25 | Birth length less than 3rd percentile (HP:0003561) | 2.43618802 |
| 26 | Abnormality of chromosome stability (HP:0003220) | 2.42438171 |
| 27 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.39979483 |
| 28 | Increased CSF lactate (HP:0002490) | 2.38421995 |
| 29 | Soft skin (HP:0000977) | 2.35869933 |
| 30 | Abnormality of the ileum (HP:0001549) | 2.35052698 |
| 31 | Protrusio acetabuli (HP:0003179) | 2.33866026 |
| 32 | Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161) | 2.33235873 |
| 33 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.32450000 |
| 34 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.32450000 |
| 35 | Mitochondrial inheritance (HP:0001427) | 2.31962868 |
| 36 | Selective tooth agenesis (HP:0001592) | 2.30968372 |
| 37 | Short tibia (HP:0005736) | 2.30680572 |
| 38 | Abnormality of methionine metabolism (HP:0010901) | 2.29838438 |
| 39 | Abnormality of glycolysis (HP:0004366) | 2.29491066 |
| 40 | Abnormal lung lobation (HP:0002101) | 2.26486133 |
| 41 | Duodenal stenosis (HP:0100867) | 2.25851331 |
| 42 | Small intestinal stenosis (HP:0012848) | 2.25851331 |
| 43 | Cerebral edema (HP:0002181) | 2.25664661 |
| 44 | Slender build (HP:0001533) | 2.23809264 |
| 45 | Entropion (HP:0000621) | 2.23025655 |
| 46 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.21033219 |
| 47 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.21033219 |
| 48 | Abnormal protein glycosylation (HP:0012346) | 2.21033219 |
| 49 | Abnormal glycosylation (HP:0012345) | 2.21033219 |
| 50 | Abnormality of the preputium (HP:0100587) | 2.19692528 |
| 51 | Redundant skin (HP:0001582) | 2.19210986 |
| 52 | Stenosis of the external auditory canal (HP:0000402) | 2.13868597 |
| 53 | Chromsome breakage (HP:0040012) | 2.13408001 |
| 54 | Mesomelia (HP:0003027) | 2.11502903 |
| 55 | Upper limb muscle weakness (HP:0003484) | 2.11293869 |
| 56 | Abdominal situs inversus (HP:0003363) | 2.09423109 |
| 57 | Abnormality of abdominal situs (HP:0011620) | 2.09423109 |
| 58 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.06871168 |
| 59 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.05242478 |
| 60 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.02275877 |
| 61 | Small hand (HP:0200055) | 2.01423459 |
| 62 | Spinal rigidity (HP:0003306) | 2.00846852 |
| 63 | Reduced antithrombin III activity (HP:0001976) | 1.96044430 |
| 64 | Abnormality of oral frenula (HP:0000190) | 1.95918113 |
| 65 | Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376) | 1.94811389 |
| 66 | Median cleft lip (HP:0000161) | 1.93819813 |
| 67 | Delayed gross motor development (HP:0002194) | 1.93408763 |
| 68 | Secondary amenorrhea (HP:0000869) | 1.93271724 |
| 69 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.89792882 |
| 70 | Ependymoma (HP:0002888) | 1.89462336 |
| 71 | Abnormality of dentin (HP:0010299) | 1.88251961 |
| 72 | Bifid tongue (HP:0010297) | 1.86824014 |
| 73 | Ectopic kidney (HP:0000086) | 1.86490456 |
| 74 | Truncus arteriosus (HP:0001660) | 1.85098231 |
| 75 | Type 1 muscle fiber predominance (HP:0003803) | 1.84519421 |
| 76 | Abnormality of the duodenum (HP:0002246) | 1.84026089 |
| 77 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 1.81851916 |
| 78 | Hepatocellular necrosis (HP:0001404) | 1.81534061 |
| 79 | Rough bone trabeculation (HP:0100670) | 1.76975175 |
| 80 | Arteriovenous malformation (HP:0100026) | 1.76342133 |
| 81 | Amniotic constriction ring (HP:0009775) | 1.75798677 |
| 82 | Abnormality of placental membranes (HP:0011409) | 1.75798677 |
| 83 | Abnormality of the middle phalanx of the 5th finger (HP:0004219) | 1.75771417 |
| 84 | Elbow flexion contracture (HP:0002987) | 1.74563769 |
| 85 | Cerebral hypomyelination (HP:0006808) | 1.72744353 |
| 86 | Increased serum lactate (HP:0002151) | 1.70313687 |
| 87 | Myelodysplasia (HP:0002863) | 1.65761275 |
| 88 | Generalized aminoaciduria (HP:0002909) | 1.65641610 |
| 89 | Hepatic necrosis (HP:0002605) | 1.65423351 |
| 90 | Degeneration of anterior horn cells (HP:0002398) | 1.62931546 |
| 91 | Abnormality of the anterior horn cell (HP:0006802) | 1.62931546 |
| 92 | Sparse eyelashes (HP:0000653) | 1.61894856 |
| 93 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.61599165 |
| 94 | Increased nuchal translucency (HP:0010880) | 1.61265397 |
| 95 | Dry hair (HP:0011359) | 1.59233999 |
| 96 | Aortic dissection (HP:0002647) | 1.58899664 |
| 97 | Nausea (HP:0002018) | 1.58765326 |
| 98 | Neoplasm of the colon (HP:0100273) | 1.58421052 |
| 99 | Horseshoe kidney (HP:0000085) | 1.57176563 |
| 100 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.56642948 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.44173396 |
| 2 | EIF2AK1 | 3.86627499 |
| 3 | PBK | 2.84332023 |
| 4 | EIF2AK3 | 2.69517482 |
| 5 | NEK1 | 2.68347149 |
| 6 | STK16 | 2.48115783 |
| 7 | TTK | 2.37509609 |
| 8 | ACVR1B | 2.26575384 |
| 9 | MST4 | 2.23092654 |
| 10 | WEE1 | 2.17786909 |
| 11 | MAP3K12 | 2.07595902 |
| 12 | CDC7 | 2.05900399 |
| 13 | NME2 | 2.02222345 |
| 14 | TSSK6 | 1.99891260 |
| 15 | MST1R | 1.99730714 |
| 16 | TIE1 | 1.96092514 |
| 17 | PLK4 | 1.94199146 |
| 18 | MYLK | 1.91821171 |
| 19 | PLK3 | 1.86501485 |
| 20 | TRIM28 | 1.81788299 |
| 21 | BMPR1B | 1.78149195 |
| 22 | SRPK1 | 1.65892357 |
| 23 | PAK4 | 1.65729510 |
| 24 | VRK2 | 1.65066453 |
| 25 | BRSK2 | 1.56471788 |
| 26 | MET | 1.47483458 |
| 27 | LIMK1 | 1.46139799 |
| 28 | ERBB4 | 1.45169908 |
| 29 | MKNK2 | 1.39652284 |
| 30 | TGFBR1 | 1.37164942 |
| 31 | ERBB3 | 1.35536938 |
| 32 | MAP3K8 | 1.34732370 |
| 33 | NME1 | 1.33880848 |
| 34 | PLK1 | 1.32814015 |
| 35 | BRSK1 | 1.28583052 |
| 36 | ZAK | 1.18726957 |
| 37 | MKNK1 | 1.14982463 |
| 38 | STK3 | 1.13069202 |
| 39 | RPS6KA4 | 1.09383413 |
| 40 | CHEK2 | 1.08315469 |
| 41 | PLK2 | 1.03010688 |
| 42 | RAF1 | 1.02304142 |
| 43 | PTK2 | 1.01383755 |
| 44 | FLT3 | 0.97870928 |
| 45 | STK10 | 0.97554799 |
| 46 | MAP3K9 | 0.96892192 |
| 47 | MAP3K2 | 0.95599351 |
| 48 | PDK2 | 0.93553920 |
| 49 | TNIK | 0.91852715 |
| 50 | DDR2 | 0.91550207 |
| 51 | TGFBR2 | 0.88845549 |
| 52 | DYRK3 | 0.88144639 |
| 53 | TESK1 | 0.87857423 |
| 54 | ILK | 0.87507106 |
| 55 | AURKB | 0.87106283 |
| 56 | MAP4K2 | 0.85409155 |
| 57 | EIF2AK2 | 0.84054602 |
| 58 | PAK2 | 0.82624718 |
| 59 | PNCK | 0.80841629 |
| 60 | PAK1 | 0.79611623 |
| 61 | VRK1 | 0.78797267 |
| 62 | KSR1 | 0.78580335 |
| 63 | SCYL2 | 0.77645310 |
| 64 | CLK1 | 0.72601441 |
| 65 | TEC | 0.72205668 |
| 66 | KSR2 | 0.71738640 |
| 67 | NTRK3 | 0.71732958 |
| 68 | LATS2 | 0.69289592 |
| 69 | NUAK1 | 0.68510090 |
| 70 | ABL2 | 0.67664285 |
| 71 | MAP3K3 | 0.66209080 |
| 72 | TAF1 | 0.62898632 |
| 73 | MELK | 0.61790049 |
| 74 | MOS | 0.60883687 |
| 75 | PAK6 | 0.59186932 |
| 76 | PTK2B | 0.57346871 |
| 77 | AURKA | 0.56863802 |
| 78 | EPHB2 | 0.55320468 |
| 79 | CHEK1 | 0.55114888 |
| 80 | BRAF | 0.54211819 |
| 81 | ATR | 0.53881620 |
| 82 | BMX | 0.52003520 |
| 83 | NEK2 | 0.51028610 |
| 84 | MAP2K1 | 0.48521592 |
| 85 | STK4 | 0.47072563 |
| 86 | PIK3CG | 0.46646068 |
| 87 | BCR | 0.45970573 |
| 88 | FGFR1 | 0.44813584 |
| 89 | CDK9 | 0.43473118 |
| 90 | TRPM7 | 0.42378244 |
| 91 | CDK3 | 0.42124353 |
| 92 | FER | 0.41061710 |
| 93 | ATM | 0.40550397 |
| 94 | CSNK2A1 | 0.39165387 |
| 95 | ROCK2 | 0.38339430 |
| 96 | ROCK1 | 0.37724231 |
| 97 | KDR | 0.36130453 |
| 98 | WNK3 | 0.36001759 |
| 99 | NEK9 | 0.35744068 |
| 100 | LATS1 | 0.35222214 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.48398248 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.32693333 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.24267394 |
| 4 | DNA replication_Homo sapiens_hsa03030 | 3.14952462 |
| 5 | Homologous recombination_Homo sapiens_hsa03440 | 2.85602559 |
| 6 | Protein export_Homo sapiens_hsa03060 | 2.67568110 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 2.53094665 |
| 8 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.26948510 |
| 9 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.22410224 |
| 10 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.18748870 |
| 11 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.13110029 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.10172586 |
| 13 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.06497174 |
| 14 | RNA transport_Homo sapiens_hsa03013 | 1.99071417 |
| 15 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.93179324 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 1.92689318 |
| 17 | Parkinsons disease_Homo sapiens_hsa05012 | 1.82456347 |
| 18 | Base excision repair_Homo sapiens_hsa03410 | 1.80117081 |
| 19 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.78746330 |
| 20 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.61420742 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.58288256 |
| 22 | Spliceosome_Homo sapiens_hsa03040 | 1.50487833 |
| 23 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.48815529 |
| 24 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.47753840 |
| 25 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.43416727 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.42406453 |
| 27 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.38765988 |
| 28 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.35526197 |
| 29 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.34924995 |
| 30 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.34499624 |
| 31 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.33783617 |
| 32 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.30616818 |
| 33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.26817179 |
| 34 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.22465521 |
| 35 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.20926593 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.20827439 |
| 37 | Ribosome_Homo sapiens_hsa03010 | 1.18083844 |
| 38 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.17719372 |
| 39 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.16008170 |
| 40 | RNA degradation_Homo sapiens_hsa03018 | 1.15822069 |
| 41 | Alzheimers disease_Homo sapiens_hsa05010 | 1.10669059 |
| 42 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.04155705 |
| 43 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.01788264 |
| 44 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 1.01453973 |
| 45 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.98796042 |
| 46 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.98472397 |
| 47 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.95524992 |
| 48 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.89783922 |
| 49 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.80471504 |
| 50 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.80233969 |
| 51 | Sulfur relay system_Homo sapiens_hsa04122 | 0.78613915 |
| 52 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.74219328 |
| 53 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.70679493 |
| 54 | Carbon metabolism_Homo sapiens_hsa01200 | 0.69112071 |
| 55 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.68757113 |
| 56 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.67989230 |
| 57 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.66313272 |
| 58 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.65557253 |
| 59 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.64722217 |
| 60 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.63889089 |
| 61 | Focal adhesion_Homo sapiens_hsa04510 | 0.63112586 |
| 62 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.62489162 |
| 63 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.62366695 |
| 64 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60954849 |
| 65 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.60376845 |
| 66 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.60050122 |
| 67 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.57841346 |
| 68 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.57056797 |
| 69 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.55076983 |
| 70 | Adherens junction_Homo sapiens_hsa04520 | 0.54219587 |
| 71 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.52636860 |
| 72 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.52169956 |
| 73 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.51187024 |
| 74 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.50752909 |
| 75 | Shigellosis_Homo sapiens_hsa05131 | 0.50228184 |
| 76 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.50075643 |
| 77 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.46510453 |
| 78 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.45696324 |
| 79 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.45612003 |
| 80 | Melanoma_Homo sapiens_hsa05218 | 0.41855143 |
| 81 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.39685280 |
| 82 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.36257956 |
| 83 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.35868212 |
| 84 | Thyroid cancer_Homo sapiens_hsa05216 | 0.35827411 |
| 85 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.34888224 |
| 86 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.33387046 |
| 87 | Galactose metabolism_Homo sapiens_hsa00052 | 0.32973418 |
| 88 | Bladder cancer_Homo sapiens_hsa05219 | 0.31461837 |
| 89 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.31177043 |
| 90 | Olfactory transduction_Homo sapiens_hsa04740 | 0.30738907 |
| 91 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.28710327 |
| 92 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.27274096 |
| 93 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.24032976 |
| 94 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.23854663 |
| 95 | Pathways in cancer_Homo sapiens_hsa05200 | 0.23634180 |
| 96 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.22127265 |
| 97 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.21925836 |
| 98 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.21314656 |
| 99 | Mineral absorption_Homo sapiens_hsa04978 | 0.19968492 |
| 100 | Melanogenesis_Homo sapiens_hsa04916 | 0.18794360 |

