STEAP1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)6.64387246
2ribosome assembly (GO:0042255)4.44047219
3DNA replication checkpoint (GO:0000076)4.43359566
4mitotic metaphase plate congression (GO:0007080)4.38560046
5negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.29529146
6CENP-A containing nucleosome assembly (GO:0034080)4.18576491
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.11233695
8chromatin remodeling at centromere (GO:0031055)4.04566971
9anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.04200462
10positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.02328436
11negative regulation of ligase activity (GO:0051352)3.98855967
12negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.98855967
13purine nucleobase biosynthetic process (GO:0009113)3.93084231
14regulation of cellular amino acid metabolic process (GO:0006521)3.77840985
15protein maturation by protein folding (GO:0022417)3.77250304
16nucleobase biosynthetic process (GO:0046112)3.73767030
17metaphase plate congression (GO:0051310)3.71812551
18protein neddylation (GO:0045116)3.55376921
19positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.50152805
20protein localization to kinetochore (GO:0034501)3.45085111
21histone exchange (GO:0043486)3.43305588
22DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.43207167
23protein-cofactor linkage (GO:0018065)3.42638293
24protein deneddylation (GO:0000338)3.41978889
25signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.40812192
26intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.40812192
27cullin deneddylation (GO:0010388)3.40766632
28signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.40624212
29signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.40624212
30signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.40624212
31mitotic sister chromatid segregation (GO:0000070)3.38795509
32protein localization to chromosome, centromeric region (GO:0071459)3.35607687
33ventricular cardiac muscle cell development (GO:0055015)3.34767135
34positive regulation of ligase activity (GO:0051351)3.31963841
35kinetochore organization (GO:0051383)3.31413947
36chaperone-mediated protein transport (GO:0072321)3.31317811
37signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28655514
38signal transduction involved in DNA damage checkpoint (GO:0072422)3.28655514
39telomere maintenance via semi-conservative replication (GO:0032201)3.27635337
40regulation of ubiquitin-protein transferase activity (GO:0051438)3.24978871
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24521561
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.21108121
43establishment of chromosome localization (GO:0051303)3.18740119
44DNA strand elongation involved in DNA replication (GO:0006271)3.15348284
45regulation of metalloenzyme activity (GO:0048552)3.13099410
46establishment of protein localization to mitochondrial membrane (GO:0090151)3.12592565
47IMP biosynthetic process (GO:0006188)3.11339894
48nucleotide-sugar biosynthetic process (GO:0009226)3.10888265
49regulation of ligase activity (GO:0051340)3.10686104
50chondrocyte proliferation (GO:0035988)3.09756988
51regulation of mitotic spindle organization (GO:0060236)3.09663978
52DNA replication-independent nucleosome organization (GO:0034724)3.09340521
53DNA replication-independent nucleosome assembly (GO:0006336)3.09340521
54mesenchymal-epithelial cell signaling (GO:0060638)3.08947041
55cell cycle G1/S phase transition (GO:0044843)3.08417472
56G1/S transition of mitotic cell cycle (GO:0000082)3.08417472
57regulation of spindle organization (GO:0090224)3.07694387
58DNA strand elongation (GO:0022616)3.06590219
59nucleobase-containing small molecule interconversion (GO:0015949)3.04182645
60maturation of 5.8S rRNA (GO:0000460)3.04148877
61mitotic G2/M transition checkpoint (GO:0044818)3.01431409
62UDP-N-acetylglucosamine metabolic process (GO:0006047)2.99399132
63lymphangiogenesis (GO:0001946)2.99021645
64nuclear pore complex assembly (GO:0051292)2.97397948
65anterior/posterior axis specification, embryo (GO:0008595)2.95296443
66mitotic recombination (GO:0006312)2.92990474
67pseudouridine synthesis (GO:0001522)2.92037210
68sister chromatid segregation (GO:0000819)2.90068633
69kinetochore assembly (GO:0051382)2.89107885
70telomere maintenance via recombination (GO:0000722)2.87935786
71transcription elongation from RNA polymerase III promoter (GO:0006385)2.87611648
72termination of RNA polymerase III transcription (GO:0006386)2.87611648
73ribosomal large subunit biogenesis (GO:0042273)2.83253197
74peptidyl-histidine modification (GO:0018202)2.83236785
75establishment of integrated proviral latency (GO:0075713)2.83062279
76protein targeting to mitochondrion (GO:0006626)2.78671666
77spindle checkpoint (GO:0031577)2.77094317
78rRNA modification (GO:0000154)2.76331765
79positive regulation of cell cycle arrest (GO:0071158)2.75981027
80DNA double-strand break processing (GO:0000729)2.75163359
81regulation of cellular amine metabolic process (GO:0033238)2.72933977
82negative regulation of protein ubiquitination (GO:0031397)2.72910669
83mitotic nuclear envelope disassembly (GO:0007077)2.72566070
84negative regulation of nitric-oxide synthase activity (GO:0051001)2.70525270
85mitotic spindle checkpoint (GO:0071174)2.69996155
86DNA catabolic process, exonucleolytic (GO:0000738)2.67484135
87IMP metabolic process (GO:0046040)2.66992952
88dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.66956142
89negative regulation of mitotic sister chromatid separation (GO:2000816)2.65890326
90negative regulation of sister chromatid segregation (GO:0033046)2.65890326
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65890326
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65890326
93negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65890326
94regulation of chromosome segregation (GO:0051983)2.64071958
95negative regulation of chromosome segregation (GO:0051985)2.62973009
96regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.62753402
97regulation of mitotic metaphase/anaphase transition (GO:0030071)2.62753402
98attachment of spindle microtubules to kinetochore (GO:0008608)2.61858297
99nuclear pore organization (GO:0006999)2.61499955
100tRNA aminoacylation for protein translation (GO:0006418)2.60431440

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.81746741
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.99844957
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.75993286
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48305834
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.40644257
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.30123705
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.29068054
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10938403
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.05708746
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05208034
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02067205
12ELK1_19687146_ChIP-ChIP_HELA_Human2.93356560
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.76261360
14AR_21909140_ChIP-Seq_LNCAP_Human2.69488353
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62877766
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58913249
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.46337619
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31110474
19PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30018299
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.23719062
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.20429990
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20404052
23E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15499777
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15314743
25DCP1A_22483619_ChIP-Seq_HELA_Human2.09263336
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.92321857
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90225930
28KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88592386
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87174784
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.82755858
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82652524
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81206932
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.77416428
34VDR_23849224_ChIP-Seq_CD4+_Human1.77012266
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.76350510
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.75891455
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.74432415
38PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.70830829
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69678861
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67329563
41GABP_19822575_ChIP-Seq_HepG2_Human1.58989702
42BRD4_25478319_ChIP-Seq_HGPS_Human1.58420389
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54376229
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51414007
45FOXP3_21729870_ChIP-Seq_TREG_Human1.46966019
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43994999
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42800203
48TTF2_22483619_ChIP-Seq_HELA_Human1.40179325
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.37883801
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36935328
51NANOG_16153702_ChIP-ChIP_HESCs_Human1.36821417
52SOX17_20123909_ChIP-Seq_XEN_Mouse1.28208290
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27818101
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.26934662
55VDR_22108803_ChIP-Seq_LS180_Human1.24884210
56ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.24878456
57DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23923929
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17974751
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17718280
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14912102
61EOMES_21245162_ChIP-Seq_HESCs_Human1.04624319
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04137411
63ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03555110
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03010586
65EWS_26573619_Chip-Seq_HEK293_Human1.02852912
66TRIM28_21343339_ChIP-Seq_HEK293_Human1.02209236
67XRN2_22483619_ChIP-Seq_HELA_Human1.01751701
68ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.01700768
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01258007
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01133241
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00444750
72MYC_18940864_ChIP-ChIP_HL60_Human0.99944419
73CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96590247
74TFEB_21752829_ChIP-Seq_HELA_Human0.96388284
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.95676207
76POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94993999
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.93742099
78KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92954024
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91880192
80TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91009208
81MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89644698
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.87317144
83SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86724478
84HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86601064
85TBX5_21415370_ChIP-Seq_HL-1_Mouse0.85800467
86CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84859105
87STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83720534
88TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.83030620
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82746165
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80744817
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79188289
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79005186
93ZNF274_21170338_ChIP-Seq_K562_Hela0.78753957
94SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78561528
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.78125208
96ELF5_23300383_ChIP-Seq_T47D_Human0.78096053
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77314477
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77314477
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75057889
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.74191627

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003950_abnormal_plasma_membrane3.99811330
2MP0008438_abnormal_cutaneous_collagen3.86040680
3MP0004272_abnormal_basement_membrane3.41145940
4MP0006054_spinal_hemorrhage3.38992256
5MP0010368_abnormal_lymphatic_system2.89320892
6MP0004957_abnormal_blastocyst_morpholog2.88043271
7MP0009697_abnormal_copulation2.86810699
8MP0010094_abnormal_chromosome_stability2.85122265
9MP0003806_abnormal_nucleotide_metabolis2.70211206
10MP0008057_abnormal_DNA_replication2.64588126
11MP0003941_abnormal_skin_development2.59950315
12MP0008007_abnormal_cellular_replicative2.56272377
13MP0003111_abnormal_nucleus_morphology2.54811372
14MP0008932_abnormal_embryonic_tissue2.54488882
15MP0003705_abnormal_hypodermis_morpholog2.49443554
16MP0003693_abnormal_embryo_hatching2.24087550
17MP0008058_abnormal_DNA_repair2.21949096
18MP0010030_abnormal_orbit_morphology2.18148806
19MP0003786_premature_aging2.17502452
20MP0003186_abnormal_redox_activity2.13592307
21MP0003077_abnormal_cell_cycle2.07607310
22MP0003890_abnormal_embryonic-extraembry1.94636744
23MP0010352_gastrointestinal_tract_polyps1.86997795
24MP0005623_abnormal_meninges_morphology1.80786564
25MP0003566_abnormal_cell_adhesion1.79549098
26MP0005275_abnormal_skin_tensile1.68391871
27MP0001879_abnormal_lymphatic_vessel1.61890695
28MP0003279_aneurysm1.57572737
29MP0001730_embryonic_growth_arrest1.55808476
30MP0005257_abnormal_intraocular_pressure1.53204502
31MP0003718_maternal_effect1.50041310
32MP0009250_abnormal_appendicular_skeleto1.49047386
33MP0002877_abnormal_melanocyte_morpholog1.44938508
34MP0009780_abnormal_chondrocyte_physiolo1.41463179
35MP0001542_abnormal_bone_strength1.39441272
36MP0008004_abnormal_stomach_pH1.36621877
37MP0002084_abnormal_developmental_patter1.32164586
38MP0000358_abnormal_cell_content/1.31445755
39MP0001697_abnormal_embryo_size1.29187903
40MP0005503_abnormal_tendon_morphology1.27714018
41MP0002295_abnormal_pulmonary_circulatio1.26132459
42MP0003937_abnormal_limbs/digits/tail_de1.25309993
43MP0005380_embryogenesis_phenotype1.23623741
44MP0001672_abnormal_embryogenesis/_devel1.23623741
45MP0000350_abnormal_cell_proliferation1.18329164
46MP0004084_abnormal_cardiac_muscle1.16495202
47MP0009053_abnormal_anal_canal1.15266737
48MP0000372_irregular_coat_pigmentation1.10811851
49MP0005023_abnormal_wound_healing1.10728299
50MP0003984_embryonic_growth_retardation1.09571180
51MP0002085_abnormal_embryonic_tissue1.08475256
52MP0001853_heart_inflammation1.07592457
53MP0002088_abnormal_embryonic_growth/wei1.05063008
54MP0000049_abnormal_middle_ear1.04521280
55MP0001299_abnormal_eye_distance/1.03895717
56MP0000749_muscle_degeneration1.03074229
57MP0002060_abnormal_skin_morphology1.02626018
58MP0000762_abnormal_tongue_morphology1.01954586
59MP0003385_abnormal_body_wall1.01360861
60MP0000428_abnormal_craniofacial_morphol0.99663294
61MP0002160_abnormal_reproductive_system0.99146605
62MP0005408_hypopigmentation0.98001758
63MP0002086_abnormal_extraembryonic_tissu0.96302908
64MP0002080_prenatal_lethality0.96129111
65MP0002102_abnormal_ear_morphology0.95255983
66MP0008775_abnormal_heart_ventricle0.94635681
67MP0001243_abnormal_dermal_layer0.93398696
68MP0006036_abnormal_mitochondrial_physio0.92321028
69MP0001881_abnormal_mammary_gland0.91096673
70MP0005330_cardiomyopathy0.90085375
71MP0006035_abnormal_mitochondrial_morpho0.89732069
72MP0005171_absent_coat_pigmentation0.87803381
73MP0001293_anophthalmia0.87318000
74MP0004147_increased_porphyrin_level0.86710338
75MP0002177_abnormal_outer_ear0.85326729
76MP0006072_abnormal_retinal_apoptosis0.85051293
77MP0002332_abnormal_exercise_endurance0.83888059
78MP0002938_white_spotting0.82065278
79MP0003935_abnormal_craniofacial_develop0.81942270
80MP0003828_pulmonary_edema0.81713975
81MP0003755_abnormal_palate_morphology0.81558616
82MP0003119_abnormal_digestive_system0.78586182
83MP0004215_abnormal_myocardial_fiber0.77674482
84MP0000432_abnormal_head_morphology0.77116412
85MP0002282_abnormal_trachea_morphology0.77018945
86MP0005360_urolithiasis0.76230383
87MP0006138_congestive_heart_failure0.76149244
88MP0005395_other_phenotype0.75583742
89MP0001915_intracranial_hemorrhage0.73366367
90MP0001529_abnormal_vocalization0.72721205
91MP0000767_abnormal_smooth_muscle0.72298360
92MP0006292_abnormal_olfactory_placode0.70989434
93MP0002233_abnormal_nose_morphology0.69077110
94MP0009384_cardiac_valve_regurgitation0.66756684
95MP0008877_abnormal_DNA_methylation0.66383574
96MP0001764_abnormal_homeostasis0.66097016
97MP0005165_increased_susceptibility_to0.65986356
98MP0005197_abnormal_uvea_morphology0.65187125
99MP0000647_abnormal_sebaceous_gland0.64996188
100MP0002210_abnormal_sex_determination0.64856320

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)4.53843736
2Acute necrotizing encephalopathy (HP:0006965)3.54597223
3Abnormality of the fetal cardiovascular system (HP:0010948)3.50293092
4Abnormal umbilical cord blood vessels (HP:0011403)3.50293092
5Single umbilical artery (HP:0001195)3.50293092
6Abnormal mitochondria in muscle tissue (HP:0008316)3.26494593
7Acute encephalopathy (HP:0006846)3.23346695
8Reduced subcutaneous adipose tissue (HP:0003758)3.13657837
9Abnormality of the umbilical cord (HP:0010881)2.91383423
10Microglossia (HP:0000171)2.85774150
11Progressive macrocephaly (HP:0004481)2.82013867
12Ankle contracture (HP:0006466)2.76552938
13Nonimmune hydrops fetalis (HP:0001790)2.76549304
14Type I transferrin isoform profile (HP:0003642)2.72382392
15Follicular hyperkeratosis (HP:0007502)2.71219361
16Short middle phalanx of the 5th finger (HP:0004220)2.66803363
17Increased serum pyruvate (HP:0003542)2.60540641
18Abnormal auditory evoked potentials (HP:0006958)2.56508496
19Meckel diverticulum (HP:0002245)2.54025340
20Coronal craniosynostosis (HP:0004440)2.53304870
21Ankyloglossia (HP:0010296)2.51508383
22Hypoplastic pelvis (HP:0008839)2.47007301
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.46556838
24Metaphyseal dysplasia (HP:0100255)2.44499767
25Birth length less than 3rd percentile (HP:0003561)2.43618802
26Abnormality of chromosome stability (HP:0003220)2.42438171
27Abnormalities of placenta or umbilical cord (HP:0001194)2.39979483
28Increased CSF lactate (HP:0002490)2.38421995
29Soft skin (HP:0000977)2.35869933
30Abnormality of the ileum (HP:0001549)2.35052698
31Protrusio acetabuli (HP:0003179)2.33866026
32Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.33235873
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.32450000
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.32450000
35Mitochondrial inheritance (HP:0001427)2.31962868
36Selective tooth agenesis (HP:0001592)2.30968372
37Short tibia (HP:0005736)2.30680572
38Abnormality of methionine metabolism (HP:0010901)2.29838438
39Abnormality of glycolysis (HP:0004366)2.29491066
40Abnormal lung lobation (HP:0002101)2.26486133
41Duodenal stenosis (HP:0100867)2.25851331
42Small intestinal stenosis (HP:0012848)2.25851331
43Cerebral edema (HP:0002181)2.25664661
44Slender build (HP:0001533)2.23809264
45Entropion (HP:0000621)2.23025655
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.21033219
47Abnormal protein N-linked glycosylation (HP:0012347)2.21033219
48Abnormal protein glycosylation (HP:0012346)2.21033219
49Abnormal glycosylation (HP:0012345)2.21033219
50Abnormality of the preputium (HP:0100587)2.19692528
51Redundant skin (HP:0001582)2.19210986
52Stenosis of the external auditory canal (HP:0000402)2.13868597
53Chromsome breakage (HP:0040012)2.13408001
54Mesomelia (HP:0003027)2.11502903
55Upper limb muscle weakness (HP:0003484)2.11293869
56Abdominal situs inversus (HP:0003363)2.09423109
57Abnormality of abdominal situs (HP:0011620)2.09423109
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06871168
59Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05242478
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.02275877
61Small hand (HP:0200055)2.01423459
62Spinal rigidity (HP:0003306)2.00846852
63Reduced antithrombin III activity (HP:0001976)1.96044430
64Abnormality of oral frenula (HP:0000190)1.95918113
65Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.94811389
66Median cleft lip (HP:0000161)1.93819813
67Delayed gross motor development (HP:0002194)1.93408763
68Secondary amenorrhea (HP:0000869)1.93271724
69Congenital ichthyosiform erythroderma (HP:0007431)1.89792882
70Ependymoma (HP:0002888)1.89462336
71Abnormality of dentin (HP:0010299)1.88251961
72Bifid tongue (HP:0010297)1.86824014
73Ectopic kidney (HP:0000086)1.86490456
74Truncus arteriosus (HP:0001660)1.85098231
75Type 1 muscle fiber predominance (HP:0003803)1.84519421
76Abnormality of the duodenum (HP:0002246)1.84026089
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.81851916
78Hepatocellular necrosis (HP:0001404)1.81534061
79Rough bone trabeculation (HP:0100670)1.76975175
80Arteriovenous malformation (HP:0100026)1.76342133
81Amniotic constriction ring (HP:0009775)1.75798677
82Abnormality of placental membranes (HP:0011409)1.75798677
83Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.75771417
84Elbow flexion contracture (HP:0002987)1.74563769
85Cerebral hypomyelination (HP:0006808)1.72744353
86Increased serum lactate (HP:0002151)1.70313687
87Myelodysplasia (HP:0002863)1.65761275
88Generalized aminoaciduria (HP:0002909)1.65641610
89Hepatic necrosis (HP:0002605)1.65423351
90Degeneration of anterior horn cells (HP:0002398)1.62931546
91Abnormality of the anterior horn cell (HP:0006802)1.62931546
92Sparse eyelashes (HP:0000653)1.61894856
93Aplasia/Hypoplasia of the tongue (HP:0010295)1.61599165
94Increased nuchal translucency (HP:0010880)1.61265397
95Dry hair (HP:0011359)1.59233999
96Aortic dissection (HP:0002647)1.58899664
97Nausea (HP:0002018)1.58765326
98Neoplasm of the colon (HP:0100273)1.58421052
99Horseshoe kidney (HP:0000085)1.57176563
100Neoplasm of the peripheral nervous system (HP:0100007)1.56642948

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.44173396
2EIF2AK13.86627499
3PBK2.84332023
4EIF2AK32.69517482
5NEK12.68347149
6STK162.48115783
7TTK2.37509609
8ACVR1B2.26575384
9MST42.23092654
10WEE12.17786909
11MAP3K122.07595902
12CDC72.05900399
13NME22.02222345
14TSSK61.99891260
15MST1R1.99730714
16TIE11.96092514
17PLK41.94199146
18MYLK1.91821171
19PLK31.86501485
20TRIM281.81788299
21BMPR1B1.78149195
22SRPK11.65892357
23PAK41.65729510
24VRK21.65066453
25BRSK21.56471788
26MET1.47483458
27LIMK11.46139799
28ERBB41.45169908
29MKNK21.39652284
30TGFBR11.37164942
31ERBB31.35536938
32MAP3K81.34732370
33NME11.33880848
34PLK11.32814015
35BRSK11.28583052
36ZAK1.18726957
37MKNK11.14982463
38STK31.13069202
39RPS6KA41.09383413
40CHEK21.08315469
41PLK21.03010688
42RAF11.02304142
43PTK21.01383755
44FLT30.97870928
45STK100.97554799
46MAP3K90.96892192
47MAP3K20.95599351
48PDK20.93553920
49TNIK0.91852715
50DDR20.91550207
51TGFBR20.88845549
52DYRK30.88144639
53TESK10.87857423
54ILK0.87507106
55AURKB0.87106283
56MAP4K20.85409155
57EIF2AK20.84054602
58PAK20.82624718
59PNCK0.80841629
60PAK10.79611623
61VRK10.78797267
62KSR10.78580335
63SCYL20.77645310
64CLK10.72601441
65TEC0.72205668
66KSR20.71738640
67NTRK30.71732958
68LATS20.69289592
69NUAK10.68510090
70ABL20.67664285
71MAP3K30.66209080
72TAF10.62898632
73MELK0.61790049
74MOS0.60883687
75PAK60.59186932
76PTK2B0.57346871
77AURKA0.56863802
78EPHB20.55320468
79CHEK10.55114888
80BRAF0.54211819
81ATR0.53881620
82BMX0.52003520
83NEK20.51028610
84MAP2K10.48521592
85STK40.47072563
86PIK3CG0.46646068
87BCR0.45970573
88FGFR10.44813584
89CDK90.43473118
90TRPM70.42378244
91CDK30.42124353
92FER0.41061710
93ATM0.40550397
94CSNK2A10.39165387
95ROCK20.38339430
96ROCK10.37724231
97KDR0.36130453
98WNK30.36001759
99NEK90.35744068
100LATS10.35222214

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.48398248
2Mismatch repair_Homo sapiens_hsa034303.32693333
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24267394
4DNA replication_Homo sapiens_hsa030303.14952462
5Homologous recombination_Homo sapiens_hsa034402.85602559
6Protein export_Homo sapiens_hsa030602.67568110
7RNA polymerase_Homo sapiens_hsa030202.53094665
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.26948510
9One carbon pool by folate_Homo sapiens_hsa006702.22410224
10Fanconi anemia pathway_Homo sapiens_hsa034602.18748870
11Fatty acid elongation_Homo sapiens_hsa000622.13110029
12Pyrimidine metabolism_Homo sapiens_hsa002402.10172586
13Nucleotide excision repair_Homo sapiens_hsa034202.06497174
14RNA transport_Homo sapiens_hsa030131.99071417
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93179324
16Cell cycle_Homo sapiens_hsa041101.92689318
17Parkinsons disease_Homo sapiens_hsa050121.82456347
18Base excision repair_Homo sapiens_hsa034101.80117081
19Oxidative phosphorylation_Homo sapiens_hsa001901.78746330
20Non-homologous end-joining_Homo sapiens_hsa034501.61420742
21Basal transcription factors_Homo sapiens_hsa030221.58288256
22Spliceosome_Homo sapiens_hsa030401.50487833
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48815529
24Sulfur metabolism_Homo sapiens_hsa009201.47753840
25ECM-receptor interaction_Homo sapiens_hsa045121.43416727
26Huntingtons disease_Homo sapiens_hsa050161.42406453
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.38765988
28Glutathione metabolism_Homo sapiens_hsa004801.35526197
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34924995
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34499624
31N-Glycan biosynthesis_Homo sapiens_hsa005101.33783617
32Folate biosynthesis_Homo sapiens_hsa007901.30616818
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.26817179
34Steroid biosynthesis_Homo sapiens_hsa001001.22465521
35Pyruvate metabolism_Homo sapiens_hsa006201.20926593
36Purine metabolism_Homo sapiens_hsa002301.20827439
37Ribosome_Homo sapiens_hsa030101.18083844
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17719372
39p53 signaling pathway_Homo sapiens_hsa041151.16008170
40RNA degradation_Homo sapiens_hsa030181.15822069
41Alzheimers disease_Homo sapiens_hsa050101.10669059
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04155705
43Propanoate metabolism_Homo sapiens_hsa006401.01788264
44TGF-beta signaling pathway_Homo sapiens_hsa043501.01453973
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.98796042
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.98472397
47Oocyte meiosis_Homo sapiens_hsa041140.95524992
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89783922
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80471504
50Selenocompound metabolism_Homo sapiens_hsa004500.80233969
51Sulfur relay system_Homo sapiens_hsa041220.78613915
52Vitamin B6 metabolism_Homo sapiens_hsa007500.74219328
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70679493
54Carbon metabolism_Homo sapiens_hsa012000.69112071
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68757113
56Biosynthesis of amino acids_Homo sapiens_hsa012300.67989230
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66313272
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65557253
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64722217
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63889089
61Focal adhesion_Homo sapiens_hsa045100.63112586
62Hippo signaling pathway_Homo sapiens_hsa043900.62489162
63Proteoglycans in cancer_Homo sapiens_hsa052050.62366695
64Metabolic pathways_Homo sapiens_hsa011000.60954849
65Small cell lung cancer_Homo sapiens_hsa052220.60376845
66Basal cell carcinoma_Homo sapiens_hsa052170.60050122
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.57841346
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57056797
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55076983
70Adherens junction_Homo sapiens_hsa045200.54219587
71Vibrio cholerae infection_Homo sapiens_hsa051100.52636860
72mRNA surveillance pathway_Homo sapiens_hsa030150.52169956
73Hedgehog signaling pathway_Homo sapiens_hsa043400.51187024
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50752909
75Shigellosis_Homo sapiens_hsa051310.50228184
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50075643
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46510453
78Wnt signaling pathway_Homo sapiens_hsa043100.45696324
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.45612003
80Melanoma_Homo sapiens_hsa052180.41855143
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39685280
82Fatty acid metabolism_Homo sapiens_hsa012120.36257956
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35868212
84Thyroid cancer_Homo sapiens_hsa052160.35827411
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34888224
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33387046
87Galactose metabolism_Homo sapiens_hsa000520.32973418
88Bladder cancer_Homo sapiens_hsa052190.31461837
89Pentose phosphate pathway_Homo sapiens_hsa000300.31177043
90Olfactory transduction_Homo sapiens_hsa047400.30738907
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28710327
92Renin-angiotensin system_Homo sapiens_hsa046140.27274096
93MicroRNAs in cancer_Homo sapiens_hsa052060.24032976
94Protein digestion and absorption_Homo sapiens_hsa049740.23854663
95Pathways in cancer_Homo sapiens_hsa052000.23634180
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22127265
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21925836
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21314656
99Mineral absorption_Homo sapiens_hsa049780.19968492
100Melanogenesis_Homo sapiens_hsa049160.18794360

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