Rank | Gene Set | Z-score |
---|---|---|
1 | protoporphyrinogen IX metabolic process (GO:0046501) | 5.94219112 |
2 | protoporphyrinogen IX biosynthetic process (GO:0006782) | 5.55616243 |
3 | heme biosynthetic process (GO:0006783) | 5.39535951 |
4 | fibrinolysis (GO:0042730) | 5.12687801 |
5 | porphyrin-containing compound biosynthetic process (GO:0006779) | 4.91172806 |
6 | negative regulation of fibrinolysis (GO:0051918) | 4.84772435 |
7 | regulation of fibrinolysis (GO:0051917) | 4.65313742 |
8 | heme metabolic process (GO:0042168) | 4.50153678 |
9 | tetrapyrrole biosynthetic process (GO:0033014) | 4.38369201 |
10 | exogenous drug catabolic process (GO:0042738) | 4.30968069 |
11 | ethanol metabolic process (GO:0006067) | 4.30103227 |
12 | epoxygenase P450 pathway (GO:0019373) | 4.28426062 |
13 | omega-hydroxylase P450 pathway (GO:0097267) | 4.17796518 |
14 | ethanol oxidation (GO:0006069) | 4.17565633 |
15 | porphyrin-containing compound metabolic process (GO:0006778) | 4.08290496 |
16 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.05994781 |
17 | L-phenylalanine metabolic process (GO:0006558) | 4.05994781 |
18 | urea metabolic process (GO:0019627) | 4.05785378 |
19 | primary alcohol catabolic process (GO:0034310) | 4.03142498 |
20 | COPI coating of Golgi vesicle (GO:0048205) | 4.01284338 |
21 | Golgi transport vesicle coating (GO:0048200) | 4.01284338 |
22 | protein heterotrimerization (GO:0070208) | 3.88005380 |
23 | lysine metabolic process (GO:0006553) | 3.87363379 |
24 | lysine catabolic process (GO:0006554) | 3.87363379 |
25 | regulation of apoptotic cell clearance (GO:2000425) | 3.83357260 |
26 | drug catabolic process (GO:0042737) | 3.74922660 |
27 | barbed-end actin filament capping (GO:0051016) | 3.73207867 |
28 | urea cycle (GO:0000050) | 3.68489070 |
29 | axonemal dynein complex assembly (GO:0070286) | 3.63612231 |
30 | regulation of plasminogen activation (GO:0010755) | 3.63050002 |
31 | nitrogen cycle metabolic process (GO:0071941) | 3.62778874 |
32 | low-density lipoprotein particle clearance (GO:0034383) | 3.57249849 |
33 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 3.56408102 |
34 | cell adhesion mediated by integrin (GO:0033627) | 3.55844344 |
35 | folic acid metabolic process (GO:0046655) | 3.55589320 |
36 | protein localization to endosome (GO:0036010) | 3.55268070 |
37 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 3.45455495 |
38 | L-phenylalanine catabolic process (GO:0006559) | 3.45455495 |
39 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 3.43304665 |
40 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 3.41311045 |
41 | negative regulation of hemostasis (GO:1900047) | 3.36517135 |
42 | negative regulation of blood coagulation (GO:0030195) | 3.36517135 |
43 | protein retention in ER lumen (GO:0006621) | 3.35342639 |
44 | keratan sulfate catabolic process (GO:0042340) | 3.32730849 |
45 | negative regulation of coagulation (GO:0050819) | 3.25734036 |
46 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 3.25699283 |
47 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.19763061 |
48 | negative regulation of wound healing (GO:0061045) | 3.14530699 |
49 | maternal placenta development (GO:0001893) | 3.11473680 |
50 | hemidesmosome assembly (GO:0031581) | 3.10877565 |
51 | valine metabolic process (GO:0006573) | 3.09087728 |
52 | acute-phase response (GO:0006953) | 3.08484303 |
53 | erythrocyte maturation (GO:0043249) | 3.05801075 |
54 | positive regulation of lipoprotein lipase activity (GO:0051006) | 3.04819875 |
55 | positive regulation of triglyceride lipase activity (GO:0061365) | 3.04819875 |
56 | regulation of cholesterol storage (GO:0010885) | 3.01047762 |
57 | DNA deamination (GO:0045006) | 3.01009578 |
58 | cellular glucuronidation (GO:0052695) | 2.99277426 |
59 | oxaloacetate metabolic process (GO:0006107) | 2.99143546 |
60 | pentose-phosphate shunt (GO:0006098) | 2.97385974 |
61 | 2-oxoglutarate metabolic process (GO:0006103) | 2.96733297 |
62 | positive regulation of hemostasis (GO:1900048) | 2.95757466 |
63 | positive regulation of blood coagulation (GO:0030194) | 2.95757466 |
64 | glyoxylate metabolic process (GO:0046487) | 2.93557831 |
65 | folic acid transport (GO:0015884) | 2.89778158 |
66 | negative regulation of cholesterol transport (GO:0032375) | 2.85917865 |
67 | negative regulation of sterol transport (GO:0032372) | 2.85917865 |
68 | regulation of complement activation (GO:0030449) | 2.85093282 |
69 | positive regulation of coagulation (GO:0050820) | 2.83938393 |
70 | collagen fibril organization (GO:0030199) | 2.83041986 |
71 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 2.82514227 |
72 | NADH metabolic process (GO:0006734) | 2.82240647 |
73 | regulation of sequestering of triglyceride (GO:0010889) | 2.82165986 |
74 | hypotonic response (GO:0006971) | 2.81340272 |
75 | drug metabolic process (GO:0017144) | 2.81016346 |
76 | glucuronate metabolic process (GO:0019585) | 2.80821718 |
77 | uronic acid metabolic process (GO:0006063) | 2.80821718 |
78 | bile acid biosynthetic process (GO:0006699) | 2.80694198 |
79 | tetrapyrrole metabolic process (GO:0033013) | 2.80528681 |
80 | positive regulation of triglyceride biosynthetic process (GO:0010867) | 2.79862321 |
81 | regulation of protein activation cascade (GO:2000257) | 2.78978159 |
82 | motile cilium assembly (GO:0044458) | 2.77556943 |
83 | pinocytosis (GO:0006907) | 2.76682779 |
84 | gas transport (GO:0015669) | 2.76517706 |
85 | skin morphogenesis (GO:0043589) | 2.74944726 |
86 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 2.72878613 |
87 | pigment biosynthetic process (GO:0046148) | 2.72228586 |
88 | tricarboxylic acid cycle (GO:0006099) | 2.72129571 |
89 | protein activation cascade (GO:0072376) | 2.71707558 |
90 | complement activation, alternative pathway (GO:0006957) | 2.71611290 |
91 | IMP biosynthetic process (GO:0006188) | 2.71528927 |
92 | regulation of metalloenzyme activity (GO:0048552) | 2.71423950 |
93 | alpha-linolenic acid metabolic process (GO:0036109) | 2.70386013 |
94 | glycine metabolic process (GO:0006544) | 2.70204732 |
95 | basement membrane organization (GO:0071711) | 2.69464747 |
96 | proline biosynthetic process (GO:0006561) | 2.69392305 |
97 | carnitine metabolic process (GO:0009437) | 2.69014537 |
98 | amino-acid betaine metabolic process (GO:0006577) | 2.67902647 |
99 | adhesion of symbiont to host (GO:0044406) | 2.67744607 |
100 | hyaluronan catabolic process (GO:0030214) | 2.67718737 |
101 | daunorubicin metabolic process (GO:0044597) | 2.67319143 |
102 | polyketide metabolic process (GO:0030638) | 2.67319143 |
103 | doxorubicin metabolic process (GO:0044598) | 2.67319143 |
104 | epithelial cell-cell adhesion (GO:0090136) | 2.66485738 |
105 | proline metabolic process (GO:0006560) | 2.66442421 |
106 | erythrocyte development (GO:0048821) | 2.66397083 |
107 | negative regulation of lipid transport (GO:0032369) | 2.66362375 |
108 | regulation of fatty acid beta-oxidation (GO:0031998) | 2.65946701 |
109 | NADPH regeneration (GO:0006740) | 2.65563683 |
110 | virion attachment to host cell (GO:0019062) | 2.65380409 |
111 | adhesion of symbiont to host cell (GO:0044650) | 2.65380409 |
112 | complement activation (GO:0006956) | 2.64630906 |
113 | complement activation, classical pathway (GO:0006958) | 2.64491707 |
114 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 2.64106122 |
115 | cysteine metabolic process (GO:0006534) | 2.62737061 |
116 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.61457201 |
117 | glycosphingolipid catabolic process (GO:0046479) | 2.60787069 |
118 | cell-substrate junction assembly (GO:0007044) | 2.60528216 |
119 | one-carbon compound transport (GO:0019755) | 2.59734899 |
120 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.59591036 |
121 | tricarboxylic acid metabolic process (GO:0072350) | 2.58964841 |
122 | fat-soluble vitamin biosynthetic process (GO:0042362) | 2.58077905 |
123 | regulation of extracellular matrix organization (GO:1903053) | 2.57767360 |
124 | bile acid metabolic process (GO:0008206) | 2.57700226 |
125 | positive regulation of triglyceride metabolic process (GO:0090208) | 2.57510607 |
126 | cellular response to zinc ion (GO:0071294) | 2.57479637 |
127 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 2.55253111 |
128 | hyaluronan metabolic process (GO:0030212) | 2.55141785 |
129 | regulation of fatty acid oxidation (GO:0046320) | 2.54891193 |
130 | DNA strand elongation involved in DNA replication (GO:0006271) | 2.54050619 |
131 | cellular response to cadmium ion (GO:0071276) | 2.52887706 |
132 | peptidyl-glutamic acid carboxylation (GO:0017187) | 2.52772249 |
133 | protein carboxylation (GO:0018214) | 2.52772249 |
134 | apoptotic cell clearance (GO:0043277) | 2.51928384 |
135 | protein maturation by protein folding (GO:0022417) | 2.51498887 |
136 | protein autoprocessing (GO:0016540) | 2.51320574 |
137 | aspartate family amino acid biosynthetic process (GO:0009067) | 2.50840220 |
138 | negative regulation of lipase activity (GO:0060192) | 2.50356795 |
139 | negative regulation of protein activation cascade (GO:2000258) | 2.50222774 |
140 | embryo implantation (GO:0007566) | 2.50152418 |
141 | desmosome organization (GO:0002934) | 2.50141565 |
142 | plasma membrane repair (GO:0001778) | 2.49878362 |
143 | positive regulation of heterotypic cell-cell adhesion (GO:0034116) | 2.49821238 |
144 | purine nucleotide salvage (GO:0032261) | 2.49426861 |
145 | positive regulation of fatty acid biosynthetic process (GO:0045723) | 2.48750680 |
146 | regulation of humoral immune response (GO:0002920) | 2.48428203 |
147 | plasma lipoprotein particle clearance (GO:0034381) | 2.47643245 |
148 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 2.46216362 |
149 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 2.46026825 |
150 | cellular response to arsenic-containing substance (GO:0071243) | 2.45527650 |
151 | glucose catabolic process (GO:0006007) | 2.44614676 |
152 | positive regulation of extracellular matrix organization (GO:1903055) | 2.44331277 |
153 | fatty acid beta-oxidation (GO:0006635) | 2.43949280 |
154 | DNA replication initiation (GO:0006270) | 2.43212451 |
155 | endodermal cell differentiation (GO:0035987) | 2.43209208 |
156 | response to thyroid hormone (GO:0097066) | 2.42177172 |
157 | positive regulation of fatty acid oxidation (GO:0046321) | 2.41301577 |
158 | aspartate family amino acid catabolic process (GO:0009068) | 2.41156898 |
159 | fatty acid transmembrane transport (GO:1902001) | 2.40509169 |
160 | ADP metabolic process (GO:0046031) | 2.40403054 |
161 | heme transport (GO:0015886) | 2.39909938 |
162 | telomere maintenance via semi-conservative replication (GO:0032201) | 2.39820704 |
163 | IMP metabolic process (GO:0046040) | 2.38148337 |
164 | collagen metabolic process (GO:0032963) | 2.36786773 |
165 | DNA strand elongation (GO:0022616) | 2.35709288 |
166 | biotin metabolic process (GO:0006768) | 2.35612369 |
167 | pigment metabolic process (GO:0042440) | 2.35405520 |
168 | folic acid-containing compound metabolic process (GO:0006760) | 2.34541725 |
169 | collagen catabolic process (GO:0030574) | 2.32908225 |
170 | positive regulation of lipid storage (GO:0010884) | 2.32005901 |
171 | AMP metabolic process (GO:0046033) | 2.30965049 |
172 | aspartate family amino acid metabolic process (GO:0009066) | 2.29626546 |
173 | galactose catabolic process (GO:0019388) | 2.28683480 |
174 | sulfur amino acid catabolic process (GO:0000098) | 2.27764304 |
175 | nucleoside salvage (GO:0043174) | 2.27075878 |
176 | serine family amino acid biosynthetic process (GO:0009070) | 2.24635995 |
177 | cellular response to thyroid hormone stimulus (GO:0097067) | 2.23654443 |
178 | regulation of triglyceride biosynthetic process (GO:0010866) | 2.23366478 |
179 | response to lead ion (GO:0010288) | 2.22740268 |
180 | carnitine shuttle (GO:0006853) | 2.22638614 |
181 | purine-containing compound salvage (GO:0043101) | 2.22602590 |
182 | organ regeneration (GO:0031100) | 2.22139646 |
183 | response to arsenic-containing substance (GO:0046685) | 2.21673838 |
184 | DNA replication checkpoint (GO:0000076) | 2.21231406 |
185 | DNA unwinding involved in DNA replication (GO:0006268) | 2.20983270 |
Rank | Gene Set | Z-score |
---|---|---|
1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.08015415 |
2 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 4.48163782 |
3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.25836994 |
4 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 3.84805504 |
5 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.65360420 |
6 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.51932377 |
7 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.46379452 |
8 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 2.38335384 |
9 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.36223569 |
10 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 2.33303832 |
11 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 2.25075055 |
12 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.22276340 |
13 | GATA1_22025678_ChIP-Seq_K562_Human | 1.96202334 |
14 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.93584958 |
15 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.89836574 |
16 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.89518317 |
17 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.84139188 |
18 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.83011719 |
19 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.80225394 |
20 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.75610539 |
21 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.71996379 |
22 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.70796037 |
23 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.69800952 |
24 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.66810601 |
25 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.60566649 |
26 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.60541280 |
27 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.59727288 |
28 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.58720495 |
29 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 1.58431642 |
30 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.58076940 |
31 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.57960237 |
32 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.56968206 |
33 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.56800357 |
34 | * TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse | 1.56477923 |
35 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.56405523 |
36 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.56255918 |
37 | MYC_22102868_ChIP-Seq_BL_Human | 1.55615645 |
38 | * NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.55314367 |
39 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 1.55032648 |
40 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.54947283 |
41 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.52838002 |
42 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.51930160 |
43 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.51930160 |
44 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.49213354 |
45 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 1.48540278 |
46 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.47772328 |
47 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.45332090 |
48 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.44542195 |
49 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 1.44488671 |
50 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.44100093 |
51 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.44050201 |
52 | SCL_19346495_ChIP-Seq_HPC-7_Human | 1.43430835 |
53 | * GATA1_19941827_ChIP-Seq_MEL_Mouse | 1.42685471 |
54 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.42179484 |
55 | GATA1_19941826_ChIP-Seq_K562_Human | 1.41077766 |
56 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.39128514 |
57 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.37229312 |
58 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 1.36936704 |
59 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.36773090 |
60 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.36122019 |
61 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.35116587 |
62 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.31944532 |
63 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 1.31780794 |
64 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.31078952 |
65 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.30987767 |
66 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.30800795 |
67 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.30174052 |
68 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.29611132 |
69 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.29162889 |
70 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.29022596 |
71 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.28211408 |
72 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.26122460 |
73 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.26066362 |
74 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.25514739 |
75 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.25044637 |
76 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.24414833 |
77 | * ATF3_27146783_Chip-Seq_COLON_Human | 1.23525792 |
78 | * NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.22079603 |
79 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.21167774 |
80 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.21076483 |
81 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.21003192 |
82 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.20785155 |
83 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.20382359 |
84 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.18361494 |
85 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.18345606 |
86 | * BRD4_27068464_Chip-Seq_AML-cells_Mouse | 1.18288529 |
87 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.18058216 |
88 | * TP53_22127205_ChIP-Seq_IMR90_Human | 1.16048278 |
89 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 1.15191441 |
90 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 1.14072682 |
91 | * NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.13397075 |
92 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.12759539 |
93 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.11576841 |
94 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.11546495 |
95 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.10993883 |
96 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.10939100 |
97 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.09368542 |
98 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.09368542 |
99 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.09316167 |
100 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 1.07545416 |
101 | MECOM_23826213_ChIP-Seq_KASUMI_Mouse | 1.06799818 |
102 | SOX2_20726797_ChIP-Seq_SW620_Human | 1.05287344 |
103 | * ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.05016114 |
104 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.04590249 |
105 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.03422522 |
106 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.03294724 |
107 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.02972603 |
108 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.02739941 |
109 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.02718538 |
110 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02178721 |
111 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.01461625 |
112 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.00265962 |
113 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 0.99744592 |
114 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.99509279 |
115 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.99478210 |
116 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.99373106 |
117 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.98674151 |
118 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.98245385 |
119 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 0.98174352 |
120 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.97968293 |
121 | * SMC4_20622854_ChIP-Seq_HELA_Human | 0.97380828 |
122 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.97343857 |
123 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.96849235 |
124 | NCOR1_26117541_ChIP-Seq_K562_Human | 0.96830675 |
125 | VDR_23849224_ChIP-Seq_CD4+_Human | 0.96749131 |
126 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.96327545 |
127 | KDM2B_26808549_Chip-Seq_K562_Human | 0.96092650 |
128 | PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse | 0.96034182 |
129 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 0.95859848 |
130 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 0.95574219 |
131 | * GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.94937500 |
132 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.94118704 |
133 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.94118489 |
134 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.93773438 |
135 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.93769007 |
136 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.93705308 |
137 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.93415002 |
138 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 0.93318560 |
139 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.91956243 |
140 | VDR_24763502_ChIP-Seq_THP-1_Human | 0.91905107 |
141 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.91456136 |
142 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.91226418 |
143 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.90868627 |
144 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.90846737 |
145 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.90771100 |
146 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.90168102 |
147 | MAF_26560356_Chip-Seq_TH1_Human | 0.90167129 |
148 | GATA2_22383799_ChIP-Seq_G1ME_Mouse | 0.90095224 |
149 | FOXP3_21729870_ChIP-Seq_TREG_Human | 0.89497945 |
150 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.88982116 |
151 | P68_20966046_ChIP-Seq_HELA_Human | 0.88961200 |
152 | * TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.88572334 |
153 | GATA2_19941826_ChIP-Seq_K562_Human | 0.88068779 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0008438_abnormal_cutaneous_collagen | 5.89373326 |
2 | * MP0003656_abnormal_erythrocyte_physiolo | 3.74882164 |
3 | MP0005275_abnormal_skin_tensile | 3.65631024 |
4 | MP0005503_abnormal_tendon_morphology | 3.25331210 |
5 | MP0004147_increased_porphyrin_level | 3.18845911 |
6 | MP0003705_abnormal_hypodermis_morpholog | 2.98493955 |
7 | MP0008875_abnormal_xenobiotic_pharmacok | 2.95766459 |
8 | MP0009840_abnormal_foam_cell | 2.68203360 |
9 | MP0006054_spinal_hemorrhage | 2.52571664 |
10 | MP0005451_abnormal_body_composition | 2.34569008 |
11 | MP0003950_abnormal_plasma_membrane | 2.26066214 |
12 | MP0003806_abnormal_nucleotide_metabolis | 2.23903975 |
13 | MP0003279_aneurysm | 2.16031025 |
14 | MP0005397_hematopoietic_system_phenotyp | 1.96607645 |
15 | MP0001545_abnormal_hematopoietic_system | 1.96607645 |
16 | MP0002877_abnormal_melanocyte_morpholog | 1.93249016 |
17 | MP0000751_myopathy | 1.92860204 |
18 | MP0001958_emphysema | 1.90872148 |
19 | MP0001849_ear_inflammation | 1.84041435 |
20 | MP0002139_abnormal_hepatobiliary_system | 1.78624304 |
21 | MP0002837_dystrophic_cardiac_calcinosis | 1.73374922 |
22 | MP0000749_muscle_degeneration | 1.72174565 |
23 | MP0000678_abnormal_parathyroid_gland | 1.71320069 |
24 | MP0005360_urolithiasis | 1.70491880 |
25 | MP0003453_abnormal_keratinocyte_physiol | 1.68088529 |
26 | MP0005623_abnormal_meninges_morphology | 1.65066229 |
27 | MP0003091_abnormal_cell_migration | 1.61891363 |
28 | MP0003566_abnormal_cell_adhesion | 1.60274169 |
29 | MP0002396_abnormal_hematopoietic_system | 1.60193854 |
30 | MP0003191_abnormal_cellular_cholesterol | 1.60104117 |
31 | MP0005670_abnormal_white_adipose | 1.59840593 |
32 | MP0000750_abnormal_muscle_regeneration | 1.51097248 |
33 | MP0003111_abnormal_nucleus_morphology | 1.50897746 |
34 | MP0009780_abnormal_chondrocyte_physiolo | 1.45552747 |
35 | MP0003195_calcinosis | 1.43110737 |
36 | MP0005058_abnormal_lysosome_morphology | 1.42999562 |
37 | MP0003186_abnormal_redox_activity | 1.42593940 |
38 | MP0003646_muscle_fatigue | 1.42502312 |
39 | MP0004130_abnormal_muscle_cell | 1.41725989 |
40 | MP0004233_abnormal_muscle_weight | 1.41629220 |
41 | MP0008775_abnormal_heart_ventricle | 1.40658031 |
42 | MP0003075_altered_response_to | 1.40564409 |
43 | MP0002060_abnormal_skin_morphology | 1.39843533 |
44 | MP0004215_abnormal_myocardial_fiber | 1.39768735 |
45 | MP0004510_myositis | 1.38506233 |
46 | MP0002896_abnormal_bone_mineralization | 1.37922881 |
47 | MP0005330_cardiomyopathy | 1.35007269 |
48 | MP0004084_abnormal_cardiac_muscle | 1.32818903 |
49 | MP0005023_abnormal_wound_healing | 1.32720958 |
50 | MP0005257_abnormal_intraocular_pressure | 1.29729605 |
51 | MP0005076_abnormal_cell_differentiation | 1.29687416 |
52 | MP0005165_increased_susceptibility_to | 1.29558193 |
53 | MP0010329_abnormal_lipoprotein_level | 1.29331588 |
54 | MP0001243_abnormal_dermal_layer | 1.29053041 |
55 | MP0005083_abnormal_biliary_tract | 1.25856282 |
56 | MP0003941_abnormal_skin_development | 1.23303610 |
57 | MP0010307_abnormal_tumor_latency | 1.21003264 |
58 | MP0003868_abnormal_feces_composition | 1.20621359 |
59 | MP0002108_abnormal_muscle_morphology | 1.19487032 |
60 | MP0001542_abnormal_bone_strength | 1.18079308 |
61 | MP0002269_muscular_atrophy | 1.17698947 |
62 | MP0000343_altered_response_to | 1.17536970 |
63 | MP0005164_abnormal_response_to | 1.17112120 |
64 | MP0005365_abnormal_bile_salt | 1.13867562 |
65 | MP0003693_abnormal_embryo_hatching | 1.13287367 |
66 | MP0005319_abnormal_enzyme/_coenzyme | 1.12764198 |
67 | MP0003436_decreased_susceptibility_to | 1.12400871 |
68 | MP0009053_abnormal_anal_canal | 1.12355573 |
69 | MP0006036_abnormal_mitochondrial_physio | 1.11126250 |
70 | MP0010234_abnormal_vibrissa_follicle | 1.09799186 |
71 | MP0002168_other_aberrant_phenotype | 1.08896066 |
72 | MP0000747_muscle_weakness | 1.08156873 |
73 | MP0005666_abnormal_adipose_tissue | 1.07624692 |
74 | MP0010352_gastrointestinal_tract_polyps | 1.07187645 |
75 | MP0004087_abnormal_muscle_fiber | 1.07159661 |
76 | MP0001666_abnormal_nutrient_absorption | 1.06884058 |
77 | * MP0000609_abnormal_liver_physiology | 1.05799859 |
78 | MP0000604_amyloidosis | 1.05293891 |
79 | MP0008260_abnormal_autophagy | 1.05125838 |
80 | MP0002332_abnormal_exercise_endurance | 1.03949713 |
81 | MP0005085_abnormal_gallbladder_physiolo | 1.03926814 |
82 | MP0003172_abnormal_lysosome_physiology | 1.03881767 |
83 | MP0010030_abnormal_orbit_morphology | 1.03330768 |
84 | MP0003300_gastrointestinal_ulcer | 0.97654275 |
85 | MP0002998_abnormal_bone_remodeling | 0.97093495 |
86 | MP0005508_abnormal_skeleton_morphology | 0.96209895 |
87 | MP0004272_abnormal_basement_membrane | 0.95567065 |
88 | MP0001661_extended_life_span | 0.93664416 |
89 | MP0002132_abnormal_respiratory_system | 0.93456260 |
90 | MP0002796_impaired_skin_barrier | 0.92780651 |
91 | MP0005332_abnormal_amino_acid | 0.90774561 |
92 | MP0001544_abnormal_cardiovascular_syste | 0.90596483 |
93 | MP0005385_cardiovascular_system_phenoty | 0.90596483 |
94 | MP0010368_abnormal_lymphatic_system | 0.90520962 |
95 | MP0000598_abnormal_liver_morphology | 0.90255627 |
96 | MP0003252_abnormal_bile_duct | 0.88473030 |
97 | MP0009278_abnormal_bone_marrow | 0.88263409 |
98 | MP0000759_abnormal_skeletal_muscle | 0.88077988 |
99 | MP0010630_abnormal_cardiac_muscle | 0.88016992 |
100 | MP0002933_joint_inflammation | 0.87812653 |
101 | MP0004858_abnormal_nervous_system | 0.87696191 |
102 | MP0000467_abnormal_esophagus_morphology | 0.87269696 |
103 | MP0001853_heart_inflammation | 0.87084214 |
104 | MP0005375_adipose_tissue_phenotype | 0.85578582 |
105 | MP0009115_abnormal_fat_cell | 0.84357609 |
106 | MP0003448_altered_tumor_morphology | 0.84335376 |
107 | MP0003303_peritoneal_inflammation | 0.83512653 |
108 | MP0009697_abnormal_copulation | 0.83387134 |
109 | MP0006082_CNS_inflammation | 0.83347297 |
110 | MP0000490_abnormal_crypts_of | 0.82585519 |
111 | MP0000767_abnormal_smooth_muscle | 0.82476066 |
112 | MP0000733_abnormal_muscle_development | 0.81612394 |
113 | MP0001216_abnormal_epidermal_layer | 0.81321278 |
114 | MP0001533_abnormal_skeleton_physiology | 0.80465462 |
115 | MP0003329_amyloid_beta_deposits | 0.80379751 |
116 | MP0004185_abnormal_adipocyte_glucose | 0.79215128 |
117 | MP0005501_abnormal_skin_physiology | 0.78491285 |
118 | MP0003077_abnormal_cell_cycle | 0.78313833 |
119 | MP0009763_increased_sensitivity_to | 0.78207687 |
120 | MP0005166_decreased_susceptibility_to | 0.77930420 |
121 | MP0002970_abnormal_white_adipose | 0.77687231 |
122 | MP0004957_abnormal_blastocyst_morpholog | 0.77683685 |
123 | MP0004808_abnormal_hematopoietic_stem | 0.77335480 |
124 | MP0005369_muscle_phenotype | 0.77274563 |
125 | MP0000762_abnormal_tongue_morphology | 0.77139952 |
126 | MP0001915_intracranial_hemorrhage | 0.76517158 |
127 | MP0004782_abnormal_surfactant_physiolog | 0.75792697 |
128 | MP0004036_abnormal_muscle_relaxation | 0.75657338 |
129 | MP0005390_skeleton_phenotype | 0.75287423 |
130 | MP0003567_abnormal_fetal_cardiomyocyte | 0.74919701 |
131 | MP0002118_abnormal_lipid_homeostasis | 0.74154281 |
132 | MP0003221_abnormal_cardiomyocyte_apopto | 0.73608998 |
133 | MP0000003_abnormal_adipose_tissue | 0.73318388 |
134 | MP0002128_abnormal_blood_circulation | 0.72415023 |
135 | MP0009931_abnormal_skin_appearance | 0.72374415 |
136 | MP0005197_abnormal_uvea_morphology | 0.72109545 |
137 | MP0009643_abnormal_urine_homeostasis | 0.71499776 |
138 | MP0002106_abnormal_muscle_physiology | 0.70456688 |
139 | MP0005409_darkened_coat_color | 0.70449613 |
140 | MP0005464_abnormal_platelet_physiology | 0.69217928 |
141 | MP0003724_increased_susceptibility_to | 0.68815297 |
142 | MP0010094_abnormal_chromosome_stability | 0.67411040 |
143 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.66800298 |
144 | MP0002089_abnormal_postnatal_growth/wei | 0.65103843 |
145 | MP0000358_abnormal_cell_content/ | 0.64755481 |
146 | MP0009384_cardiac_valve_regurgitation | 0.64263143 |
147 | MP0000858_altered_metastatic_potential | 0.63980017 |
148 | MP0008469_abnormal_protein_level | 0.61258401 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Protrusio acetabuli (HP:0003179) | 6.00898142 |
2 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 5.63376772 |
3 | Ankle contracture (HP:0006466) | 5.25173312 |
4 | Premature rupture of membranes (HP:0001788) | 5.22716242 |
5 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 5.00580784 |
6 | Increased connective tissue (HP:0009025) | 4.06442026 |
7 | Reticulocytosis (HP:0001923) | 3.69173340 |
8 | Type 1 muscle fiber predominance (HP:0003803) | 3.59861766 |
9 | Poikilocytosis (HP:0004447) | 3.50532477 |
10 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 3.47080330 |
11 | Vertebral compression fractures (HP:0002953) | 3.44216855 |
12 | Slender build (HP:0001533) | 3.42297508 |
13 | Cervical subluxation (HP:0003308) | 3.33725127 |
14 | Nonimmune hydrops fetalis (HP:0001790) | 3.23701904 |
15 | Conjugated hyperbilirubinemia (HP:0002908) | 3.21040709 |
16 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 3.20153342 |
17 | Broad metatarsal (HP:0001783) | 3.18596286 |
18 | Short nail (HP:0001799) | 3.02630708 |
19 | Glomerulonephritis (HP:0000099) | 2.96209152 |
20 | Soft skin (HP:0000977) | 2.89705284 |
21 | Distal lower limb muscle weakness (HP:0009053) | 2.89651312 |
22 | Cardiovascular calcification (HP:0011915) | 2.86819910 |
23 | Biconcave vertebral bodies (HP:0004586) | 2.85708471 |
24 | Nausea (HP:0002018) | 2.83727890 |
25 | Polycythemia (HP:0001901) | 2.83589664 |
26 | Abnormal number of erythroid precursors (HP:0012131) | 2.82298341 |
27 | Abnormality of glycolipid metabolism (HP:0010969) | 2.81653115 |
28 | Abnormality of liposaccharide metabolism (HP:0010968) | 2.81653115 |
29 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 2.81653115 |
30 | Follicular hyperkeratosis (HP:0007502) | 2.81012062 |
31 | Nasal polyposis (HP:0100582) | 2.80898875 |
32 | Spinal rigidity (HP:0003306) | 2.80718913 |
33 | Vascular calcification (HP:0004934) | 2.80318974 |
34 | Abnormality of the nasal mucosa (HP:0000433) | 2.79665100 |
35 | Myocardial infarction (HP:0001658) | 2.78246982 |
36 | Diaphragmatic weakness (HP:0009113) | 2.77070348 |
37 | Prolonged partial thromboplastin time (HP:0003645) | 2.76926581 |
38 | Cholelithiasis (HP:0001081) | 2.72403120 |
39 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.71901021 |
40 | Mitral stenosis (HP:0001718) | 2.71534572 |
41 | Acanthocytosis (HP:0001927) | 2.66699111 |
42 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.65861270 |
43 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.65861270 |
44 | Cerebral aneurysm (HP:0004944) | 2.63795947 |
45 | Generalized amyotrophy (HP:0003700) | 2.62204706 |
46 | Nuclear cataract (HP:0100018) | 2.59900623 |
47 | Abnormality of reticulocytes (HP:0004312) | 2.59337524 |
48 | Rhinitis (HP:0012384) | 2.58366372 |
49 | Aortic dissection (HP:0002647) | 2.55314529 |
50 | Intrahepatic cholestasis (HP:0001406) | 2.54854794 |
51 | Xanthomatosis (HP:0000991) | 2.53862637 |
52 | Hyperbilirubinemia (HP:0002904) | 2.52789018 |
53 | Shallow orbits (HP:0000586) | 2.51972430 |
54 | Fragile skin (HP:0001030) | 2.51291185 |
55 | Abnormal ciliary motility (HP:0012262) | 2.51196906 |
56 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.50385860 |
57 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.50288745 |
58 | Muscle fiber splitting (HP:0003555) | 2.49909666 |
59 | Distal upper limb amyotrophy (HP:0007149) | 2.49019382 |
60 | Upper limb amyotrophy (HP:0009129) | 2.49019382 |
61 | Peritonitis (HP:0002586) | 2.38977201 |
62 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.37255899 |
63 | Absent/shortened dynein arms (HP:0200106) | 2.37255899 |
64 | Joint hemorrhage (HP:0005261) | 2.35970221 |
65 | Abnormality of the acetabulum (HP:0003170) | 2.34807542 |
66 | Nephritis (HP:0000123) | 2.34200039 |
67 | Hypoalphalipoproteinemia (HP:0003233) | 2.34049885 |
68 | Abnormal gallbladder morphology (HP:0012437) | 2.32334211 |
69 | Exercise-induced muscle cramps (HP:0003710) | 2.29843779 |
70 | Deep venous thrombosis (HP:0002625) | 2.29195712 |
71 | Lipoatrophy (HP:0100578) | 2.28422713 |
72 | Asymmetric septal hypertrophy (HP:0001670) | 2.26284587 |
73 | Ileus (HP:0002595) | 2.25716825 |
74 | Arterial tortuosity (HP:0005116) | 2.25604069 |
75 | Rhabdomyolysis (HP:0003201) | 2.25220227 |
76 | Increased variability in muscle fiber diameter (HP:0003557) | 2.23056381 |
77 | Difficulty climbing stairs (HP:0003551) | 2.21835678 |
78 | Mucopolysacchariduria (HP:0008155) | 2.20355264 |
79 | Urinary glycosaminoglycan excretion (HP:0003541) | 2.20355264 |
80 | Wrist flexion contracture (HP:0001239) | 2.19761186 |
81 | Complement deficiency (HP:0004431) | 2.19443007 |
82 | Abnormality of the intrinsic pathway (HP:0010989) | 2.19293454 |
83 | * Increased serum ferritin (HP:0003281) | 2.19093888 |
84 | Vascular tortuosity (HP:0004948) | 2.16058379 |
85 | Genu recurvatum (HP:0002816) | 2.15960618 |
86 | Abnormality of the common coagulation pathway (HP:0010990) | 2.14760137 |
87 | Mildly elevated creatine phosphokinase (HP:0008180) | 2.13040474 |
88 | Hypobetalipoproteinemia (HP:0003563) | 2.12688038 |
89 | Dysostosis multiplex (HP:0000943) | 2.12005299 |
90 | Hyperlipoproteinemia (HP:0010980) | 2.11951532 |
91 | Abnormal delivery (HP:0001787) | 2.11935824 |
92 | Petechiae (HP:0000967) | 2.11680909 |
93 | Distal lower limb amyotrophy (HP:0008944) | 2.10943085 |
94 | Abnormality of polysaccharide metabolism (HP:0011012) | 2.10888672 |
95 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 2.10888672 |
96 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 2.10888672 |
97 | Flat acetabular roof (HP:0003180) | 2.10336623 |
98 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.08794014 |
99 | Hand muscle atrophy (HP:0009130) | 2.07104698 |
100 | Amyloidosis (HP:0011034) | 2.07101401 |
101 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.06578358 |
102 | Osteolytic defects of the hand bones (HP:0009699) | 2.06578358 |
103 | Abnormality of the Achilles tendon (HP:0005109) | 2.05891182 |
104 | Achilles tendon contracture (HP:0001771) | 2.04870128 |
105 | Back pain (HP:0003418) | 2.04634547 |
106 | Blue sclerae (HP:0000592) | 2.04265954 |
107 | Hyperammonemia (HP:0001987) | 2.03851413 |
108 | Chronic bronchitis (HP:0004469) | 2.03800153 |
109 | Abnormality of fatty-acid metabolism (HP:0004359) | 2.03496649 |
110 | Mesangial abnormality (HP:0001966) | 2.03222466 |
111 | Abnormal cartilage morphology (HP:0002763) | 2.03013519 |
112 | Myoglobinuria (HP:0002913) | 2.02150221 |
113 | Bladder diverticulum (HP:0000015) | 2.01965503 |
114 | Natal tooth (HP:0000695) | 2.01495520 |
115 | Dilatation of the ascending aorta (HP:0005111) | 2.01367873 |
116 | Ulnar bowing (HP:0003031) | 2.00676195 |
117 | Abnormality of complement system (HP:0005339) | 1.99316823 |
118 | Slender long bone (HP:0003100) | 1.99292094 |
119 | Hyperacusis (HP:0010780) | 1.97992654 |
120 | Ventricular tachycardia (HP:0004756) | 1.97431881 |
121 | Hemorrhage of the eye (HP:0011885) | 1.97046083 |
122 | Elbow flexion contracture (HP:0002987) | 1.96181334 |
123 | Multiple enchondromatosis (HP:0005701) | 1.95571904 |
124 | * Abnormality of iron homeostasis (HP:0011031) | 1.93432946 |
125 | Abnormality of dentin (HP:0010299) | 1.92921493 |
126 | Breech presentation (HP:0001623) | 1.92779947 |
127 | Wormian bones (HP:0002645) | 1.91867539 |
128 | Hypertriglyceridemia (HP:0002155) | 1.91737442 |
129 | J-shaped sella turcica (HP:0002680) | 1.91219981 |
130 | Global brain atrophy (HP:0002283) | 1.90355673 |
131 | Aortic aneurysm (HP:0004942) | 1.90293344 |
132 | Increased cerebral lipofuscin (HP:0011813) | 1.89868605 |
133 | Recurrent gram-negative bacterial infections (HP:0005420) | 1.87828411 |
134 | Abnormality of carpal bone ossification (HP:0006257) | 1.87757748 |
135 | Abnormal gallbladder physiology (HP:0012438) | 1.87742528 |
136 | Cholecystitis (HP:0001082) | 1.87742528 |
137 | Neoplasm of head and neck (HP:0012288) | 1.84883645 |
138 | Esophageal neoplasm (HP:0100751) | 1.84883645 |
139 | Hypercholesterolemia (HP:0003124) | 1.83350631 |
140 | Systemic lupus erythematosus (HP:0002725) | 1.83132253 |
141 | Hepatocellular carcinoma (HP:0001402) | 1.82569442 |
142 | Hyperglycinuria (HP:0003108) | 1.82473600 |
143 | Absent frontal sinuses (HP:0002688) | 1.82361453 |
144 | Interstitial pulmonary disease (HP:0006530) | 1.81132565 |
145 | * Abnormality of transition element cation homeostasis (HP:0011030) | 1.80242224 |
146 | Neurofibrillary tangles (HP:0002185) | 1.80220915 |
147 | Joint stiffness (HP:0001387) | 1.79983104 |
148 | Beaking of vertebral bodies (HP:0004568) | 1.79676924 |
149 | Atrophic scars (HP:0001075) | 1.78802189 |
150 | Hypoglycemic coma (HP:0001325) | 1.78458613 |
151 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.77836883 |
152 | Male infertility (HP:0003251) | 1.77311690 |
153 | Axonal loss (HP:0003447) | 1.75341927 |
154 | Purpura (HP:0000979) | 1.74634389 |
155 | Mitral valve prolapse (HP:0001634) | 1.74595572 |
156 | Prolonged bleeding time (HP:0003010) | 1.73655665 |
157 | Neonatal short-limb short stature (HP:0008921) | 1.73389173 |
158 | Hypolipoproteinemia (HP:0010981) | 1.71377317 |
159 | Alopecia of scalp (HP:0002293) | 1.69789022 |
160 | Selective tooth agenesis (HP:0001592) | 1.69258411 |
161 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.68509283 |
162 | Dicarboxylic aciduria (HP:0003215) | 1.68509283 |
163 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 1.66919143 |
164 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 1.64989695 |
165 | Skin nodule (HP:0200036) | 1.64947750 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TRIB3 | 4.29509295 |
2 | NME2 | 3.73602251 |
3 | PKN2 | 3.12414049 |
4 | TTN | 3.10924083 |
5 | ERN1 | 2.69516224 |
6 | EIF2AK1 | 2.63316793 |
7 | EEF2K | 2.54582939 |
8 | SMG1 | 2.44239077 |
9 | SIK1 | 2.40769032 |
10 | BCKDK | 2.40233442 |
11 | BUB1 | 2.35904702 |
12 | TESK1 | 2.29902958 |
13 | ICK | 2.29766117 |
14 | NEK1 | 2.02893594 |
15 | PIM2 | 1.99736689 |
16 | SCYL2 | 1.76869238 |
17 | MAPK15 | 1.74197988 |
18 | WEE1 | 1.71293525 |
19 | LIMK1 | 1.71198916 |
20 | KDR | 1.68818867 |
21 | PTK2 | 1.68307624 |
22 | PRPF4B | 1.66770000 |
23 | ARAF | 1.65090555 |
24 | DDR2 | 1.62730485 |
25 | MET | 1.60538485 |
26 | NEK2 | 1.54181735 |
27 | MOS | 1.50443084 |
28 | TGFBR2 | 1.49429090 |
29 | MAP3K10 | 1.42711321 |
30 | FLT3 | 1.42428170 |
31 | LRRK2 | 1.40261228 |
32 | MAP2K3 | 1.38382751 |
33 | TRPM7 | 1.32408492 |
34 | KIT | 1.32063913 |
35 | STK3 | 1.24801524 |
36 | PDGFRA | 1.23878970 |
37 | ERBB4 | 1.23009605 |
38 | MAPKAPK3 | 1.19818294 |
39 | RPS6KA4 | 1.19694125 |
40 | CAMK1D | 1.15267206 |
41 | ABL2 | 1.14887724 |
42 | STK4 | 1.13262832 |
43 | NEK9 | 1.11572179 |
44 | STK24 | 1.11527557 |
45 | NTRK1 | 1.08735556 |
46 | ZAK | 1.08157877 |
47 | PAK4 | 1.06844664 |
48 | MAPK11 | 1.06356471 |
49 | PDK3 | 1.06207150 |
50 | PDK4 | 1.06207150 |
51 | CDC7 | 1.06115599 |
52 | LMTK2 | 1.05277657 |
53 | TTK | 0.98495412 |
54 | CDK4 | 0.97553773 |
55 | DYRK3 | 0.96872828 |
56 | PAK2 | 0.96239836 |
57 | CDC42BPA | 0.94794097 |
58 | MAP3K11 | 0.94195525 |
59 | BMX | 0.93853973 |
60 | STK10 | 0.93342069 |
61 | MYLK | 0.93224883 |
62 | MAP3K13 | 0.92777302 |
63 | TYK2 | 0.92047618 |
64 | TBK1 | 0.91670789 |
65 | MAP3K8 | 0.90657744 |
66 | IRAK3 | 0.90003806 |
67 | PIM1 | 0.87545817 |
68 | PBK | 0.86760384 |
69 | BRSK2 | 0.86285746 |
70 | MAP3K3 | 0.85092136 |
71 | PTK6 | 0.83986033 |
72 | LATS2 | 0.83563888 |
73 | EPHB2 | 0.82924212 |
74 | CDK12 | 0.81846982 |
75 | CDK7 | 0.80117692 |
76 | RIPK1 | 0.78597048 |
77 | ILK | 0.77402169 |
78 | ZAP70 | 0.75448870 |
79 | BRSK1 | 0.72039868 |
80 | MAP3K6 | 0.71967409 |
81 | AURKB | 0.71307854 |
82 | MAP3K2 | 0.70278615 |
83 | RPS6KB2 | 0.70046011 |
84 | JAK2 | 0.68634241 |
85 | RPS6KA2 | 0.68508810 |
86 | PDPK1 | 0.66747732 |
87 | STK38 | 0.65849285 |
88 | MTOR | 0.65612081 |
89 | PLK1 | 0.64475294 |
90 | MAP3K14 | 0.63899793 |
91 | PRKD2 | 0.63483760 |
92 | MST1R | 0.61993898 |
93 | OBSCN | 0.61524590 |
94 | MAPK12 | 0.58431480 |
95 | CDK6 | 0.57025809 |
96 | MAP3K1 | 0.56913401 |
97 | PAK1 | 0.56627524 |
98 | BRAF | 0.56615072 |
99 | TLK1 | 0.54466984 |
100 | KSR2 | 0.52891586 |
101 | JAK3 | 0.52579017 |
102 | CAMK2G | 0.52302724 |
103 | PDK2 | 0.51338904 |
104 | PDGFRB | 0.51078167 |
105 | JAK1 | 0.51000339 |
106 | LATS1 | 0.50119327 |
107 | ROCK2 | 0.49934557 |
108 | FGFR4 | 0.49930588 |
109 | DAPK3 | 0.49025568 |
110 | MAPKAPK2 | 0.48618392 |
111 | AURKA | 0.48442651 |
112 | ATR | 0.47695643 |
113 | PRKG2 | 0.47367496 |
114 | PIK3CG | 0.46974422 |
115 | EIF2AK3 | 0.46960901 |
116 | TESK2 | 0.46297834 |
117 | STK16 | 0.45986127 |
118 | GSK3A | 0.45865810 |
119 | IKBKB | 0.44387035 |
120 | BLK | 0.44286035 |
121 | CSF1R | 0.43919064 |
122 | PHKG1 | 0.42414971 |
123 | PHKG2 | 0.42414971 |
124 | PRKAA2 | 0.41310937 |
125 | AKT2 | 0.41193989 |
126 | TIE1 | 0.40662977 |
127 | MAP4K1 | 0.40577960 |
128 | RPS6KA6 | 0.40047661 |
129 | GRK7 | 0.40006647 |
130 | EPHA2 | 0.39842788 |
131 | EPHB1 | 0.39378051 |
132 | MST4 | 0.39044800 |
133 | TAOK2 | 0.38600029 |
134 | RPS6KL1 | 0.37961032 |
135 | RPS6KC1 | 0.37961032 |
136 | ROCK1 | 0.36943965 |
137 | DMPK | 0.34324888 |
138 | MAP3K12 | 0.32600983 |
139 | CDK8 | 0.30771741 |
140 | CLK1 | 0.29889781 |
141 | TAOK1 | 0.29472268 |
142 | HIPK2 | 0.27507069 |
143 | MELK | 0.24848668 |
144 | NME1 | 0.23910694 |
Rank | Gene Set | Z-score |
---|---|---|
1 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.94745420 |
2 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 2.90090409 |
3 | Caffeine metabolism_Homo sapiens_hsa00232 | 2.79009281 |
4 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.78127764 |
5 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 2.52718758 |
6 | DNA replication_Homo sapiens_hsa03030 | 2.48462445 |
7 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.25191389 |
8 | Tyrosine metabolism_Homo sapiens_hsa00350 | 2.18359190 |
9 | Retinol metabolism_Homo sapiens_hsa00830 | 2.05689486 |
10 | Prion diseases_Homo sapiens_hsa05020 | 1.95671549 |
11 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.94818082 |
12 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.90129917 |
13 | Carbon metabolism_Homo sapiens_hsa01200 | 1.90063447 |
14 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.80203277 |
15 | Histidine metabolism_Homo sapiens_hsa00340 | 1.77928532 |
16 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.76879629 |
17 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.73660367 |
18 | PPAR signaling pathway_Homo sapiens_hsa03320 | 1.72169827 |
19 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.70637212 |
20 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.69161741 |
21 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.68133196 |
22 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.61623403 |
23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.61263486 |
24 | Sulfur relay system_Homo sapiens_hsa04122 | 1.59140685 |
25 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.55178351 |
26 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 1.54850602 |
27 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.50375358 |
28 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.45644159 |
29 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.40715402 |
30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.37956751 |
31 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.36658196 |
32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.35555949 |
33 | ECM-receptor interaction_Homo sapiens_hsa04512 | 1.34020557 |
34 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.31645535 |
35 | Ribosome_Homo sapiens_hsa03010 | 1.30886349 |
36 | Proteasome_Homo sapiens_hsa03050 | 1.29942964 |
37 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.29821020 |
38 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.28340274 |
39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.25869944 |
40 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 1.23244848 |
41 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.22049767 |
42 | Arginine biosynthesis_Homo sapiens_hsa00220 | 1.21558073 |
43 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 1.21058213 |
44 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.18159490 |
45 | Galactose metabolism_Homo sapiens_hsa00052 | 1.15822588 |
46 | Mismatch repair_Homo sapiens_hsa03430 | 1.15142749 |
47 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.14960257 |
48 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.12581205 |
49 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 1.10087347 |
50 | Peroxisome_Homo sapiens_hsa04146 | 1.09926449 |
51 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.07918108 |
52 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.07651001 |
53 | Base excision repair_Homo sapiens_hsa03410 | 1.06323233 |
54 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.04798753 |
55 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.03393577 |
56 | Malaria_Homo sapiens_hsa05144 | 1.01731313 |
57 | Lysosome_Homo sapiens_hsa04142 | 1.01692963 |
58 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.00917621 |
59 | Cell cycle_Homo sapiens_hsa04110 | 0.99289872 |
60 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.96547970 |
61 | Pertussis_Homo sapiens_hsa05133 | 0.95635118 |
62 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.88891018 |
63 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.86868256 |
64 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.84048805 |
65 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.82873765 |
66 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.79548636 |
67 | Other glycan degradation_Homo sapiens_hsa00511 | 0.78938205 |
68 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.78868267 |
69 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.76504505 |
70 | Bladder cancer_Homo sapiens_hsa05219 | 0.76364994 |
71 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.74912495 |
72 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.73766885 |
73 | ABC transporters_Homo sapiens_hsa02010 | 0.73506591 |
74 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.73099709 |
75 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.72796289 |
76 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.71059754 |
77 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.69692293 |
78 | RNA transport_Homo sapiens_hsa03013 | 0.68599609 |
79 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.66989983 |
80 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.65607887 |
81 | * p53 signaling pathway_Homo sapiens_hsa04115 | 0.65168790 |
82 | Amoebiasis_Homo sapiens_hsa05146 | 0.65017630 |
83 | Lysine degradation_Homo sapiens_hsa00310 | 0.64487802 |
84 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.62981688 |
85 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.62522557 |
86 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.61652251 |
87 | RNA polymerase_Homo sapiens_hsa03020 | 0.60927195 |
88 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.60690194 |
89 | Focal adhesion_Homo sapiens_hsa04510 | 0.59155551 |
90 | Mineral absorption_Homo sapiens_hsa04978 | 0.57894068 |
91 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.55748889 |
92 | Insulin resistance_Homo sapiens_hsa04931 | 0.55433520 |
93 | Homologous recombination_Homo sapiens_hsa03440 | 0.54678511 |
94 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.54540980 |
95 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.54180240 |
96 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.53939620 |
97 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.53417106 |
98 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.52714083 |
99 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.52456858 |
100 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.51152245 |
101 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.50887669 |
102 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.50214455 |
103 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.49712814 |
104 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.48484783 |
105 | Apoptosis_Homo sapiens_hsa04210 | 0.48325345 |
106 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.48031888 |
107 | Legionellosis_Homo sapiens_hsa05134 | 0.47921145 |
108 | Spliceosome_Homo sapiens_hsa03040 | 0.47622057 |
109 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.47241505 |
110 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47218412 |
111 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.46976345 |
112 | Salmonella infection_Homo sapiens_hsa05132 | 0.46668936 |
113 | Adherens junction_Homo sapiens_hsa04520 | 0.44845096 |
114 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.44646553 |
115 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.44145046 |
116 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.43972922 |
117 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.41397895 |
118 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.40924072 |
119 | Hepatitis C_Homo sapiens_hsa05160 | 0.40420769 |
120 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.39367194 |
121 | Bile secretion_Homo sapiens_hsa04976 | 0.38175806 |
122 | Purine metabolism_Homo sapiens_hsa00230 | 0.37467885 |
123 | Thyroid cancer_Homo sapiens_hsa05216 | 0.36010306 |
124 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.35821272 |
125 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.35506886 |
126 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.35271500 |
127 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.33873008 |
128 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.32127010 |
129 | Phagosome_Homo sapiens_hsa04145 | 0.31339161 |
130 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.30536876 |
131 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.30443919 |
132 | Shigellosis_Homo sapiens_hsa05131 | 0.29036239 |
133 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.26846161 |
134 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.25803960 |