STEAP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)6.26361927
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.19660886
3L-phenylalanine catabolic process (GO:0006559)6.19660886
4L-phenylalanine metabolic process (GO:0006558)5.93985694
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.93985694
6positive regulation by symbiont of host defense response (GO:0052509)5.93399148
7modulation by symbiont of host defense response (GO:0052031)5.93399148
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.93399148
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.93399148
10positive regulation by organism of defense response of other organism involved in symbiotic interact5.93399148
11modulation by symbiont of host immune response (GO:0052553)5.93399148
12complement activation, alternative pathway (GO:0006957)5.91141377
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.71031682
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.57485140
15regulation of protein activation cascade (GO:2000257)5.51565792
16aromatic amino acid family catabolic process (GO:0009074)5.42342403
17alpha-linolenic acid metabolic process (GO:0036109)5.40243482
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.34031021
19negative regulation of cell killing (GO:0031342)5.34031021
20regulation of complement activation (GO:0030449)5.18607712
21positive regulation of gamma-delta T cell activation (GO:0046645)5.11121406
22detection of external biotic stimulus (GO:0098581)5.03296945
23macrophage activation involved in immune response (GO:0002281)5.01722567
24urea metabolic process (GO:0019627)4.98832605
25urea cycle (GO:0000050)4.98832605
26positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.97117503
27peptidyl-glutamic acid carboxylation (GO:0017187)4.86385784
28protein carboxylation (GO:0018214)4.86385784
29negative regulation of fibrinolysis (GO:0051918)4.85298221
30sulfur amino acid catabolic process (GO:0000098)4.84316176
31bile acid biosynthetic process (GO:0006699)4.83051480
32regulation of triglyceride catabolic process (GO:0010896)4.82457251
33detection of other organism (GO:0098543)4.80047301
34indole-containing compound catabolic process (GO:0042436)4.77242587
35indolalkylamine catabolic process (GO:0046218)4.77242587
36tryptophan catabolic process (GO:0006569)4.77242587
37glyoxylate metabolic process (GO:0046487)4.74835405
38kynurenine metabolic process (GO:0070189)4.73198038
39regulation of fibrinolysis (GO:0051917)4.69763544
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.69522446
41microglial cell activation (GO:0001774)4.62555103
42nitrogen cycle metabolic process (GO:0071941)4.58102780
43cysteine metabolic process (GO:0006534)4.53613495
44cellular extravasation (GO:0045123)4.52972320
45plasma lipoprotein particle clearance (GO:0034381)4.52263722
46triglyceride homeostasis (GO:0070328)4.51860195
47acylglycerol homeostasis (GO:0055090)4.51860195
48tryptophan metabolic process (GO:0006568)4.48922586
49positive regulation of fatty acid beta-oxidation (GO:0032000)4.47349372
50low-density lipoprotein particle clearance (GO:0034383)4.45274703
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45254049
52regulation of interferon-beta biosynthetic process (GO:0045357)4.42486787
53high-density lipoprotein particle remodeling (GO:0034375)4.38648505
54regulation of B cell receptor signaling pathway (GO:0050855)4.31387052
55detection of biotic stimulus (GO:0009595)4.30017870
56valine metabolic process (GO:0006573)4.24259434
57negative regulation of lymphocyte mediated immunity (GO:0002707)4.21958866
58antigen processing and presentation of endogenous antigen (GO:0019883)4.21925729
59detection of bacterium (GO:0016045)4.20454205
60bile acid metabolic process (GO:0008206)4.19405315
61lysine catabolic process (GO:0006554)4.17604162
62lysine metabolic process (GO:0006553)4.17604162
63macrophage activation (GO:0042116)4.17255821
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.15788036
65response to host immune response (GO:0052572)4.15788036
66neutrophil activation involved in immune response (GO:0002283)4.14036434
67serine family amino acid catabolic process (GO:0009071)4.11406964
68positive regulation of lipid catabolic process (GO:0050996)4.11175456
69homocysteine metabolic process (GO:0050667)4.10683505
70negative regulation of complement activation (GO:0045916)4.10117877
71reverse cholesterol transport (GO:0043691)4.07389697
72amino-acid betaine metabolic process (GO:0006577)4.05630931
73regulation of gamma-delta T cell activation (GO:0046643)4.05212596
74tyrosine metabolic process (GO:0006570)4.01990771
75plasma lipoprotein particle remodeling (GO:0034369)4.00821209
76protein-lipid complex remodeling (GO:0034368)4.00821209
77macromolecular complex remodeling (GO:0034367)4.00821209
78response to peptidoglycan (GO:0032494)3.98444706
79regulation of sequestering of triglyceride (GO:0010889)3.97477535
80positive regulation of fatty acid oxidation (GO:0046321)3.96200983
81negative regulation of humoral immune response (GO:0002921)3.95206658
82negative regulation of protein activation cascade (GO:2000258)3.92409289
83triglyceride catabolic process (GO:0019433)3.92125547
84positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.91830739
85negative regulation of B cell mediated immunity (GO:0002713)3.90768055
86negative regulation of immunoglobulin mediated immune response (GO:0002890)3.90768055
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.90490559
88antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90096392
89fatty acid beta-oxidation (GO:0006635)3.88364340
90aromatic amino acid family metabolic process (GO:0009072)3.86993710
91acetyl-CoA metabolic process (GO:0006084)3.86808302
92neutrophil mediated immunity (GO:0002446)3.86665177
93leukocyte migration involved in inflammatory response (GO:0002523)3.85048961
94response to host (GO:0075136)3.84998295
95response to host defenses (GO:0052200)3.84998295
96response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.84998295
97alpha-amino acid catabolic process (GO:1901606)3.84759240
98complement activation (GO:0006956)3.84503457
99acute-phase response (GO:0006953)3.82872043
100regulation of cholesterol esterification (GO:0010872)3.82699194
101ethanol oxidation (GO:0006069)3.82192136
102phospholipid efflux (GO:0033700)3.81514487
103acylglycerol catabolic process (GO:0046464)3.81426152
104neutral lipid catabolic process (GO:0046461)3.81426152
105fatty acid oxidation (GO:0019395)3.81410239
106regulation of gamma-delta T cell differentiation (GO:0045586)3.78670220
107production of molecular mediator involved in inflammatory response (GO:0002532)3.75247273
108negative regulation of interleukin-12 production (GO:0032695)3.74101583
109lipid oxidation (GO:0034440)3.74054470
110complement activation, classical pathway (GO:0006958)3.73323056
111fatty acid transmembrane transport (GO:1902001)3.73228289
112response to interleukin-15 (GO:0070672)3.72788800
113cytolysis (GO:0019835)3.72747316
114phospholipid homeostasis (GO:0055091)3.69301720
115fibrinolysis (GO:0042730)3.67411801
116coenzyme catabolic process (GO:0009109)3.66701036
1172-oxoglutarate metabolic process (GO:0006103)3.63749612
118fatty acid catabolic process (GO:0009062)3.62874326
119negative regulation of lipase activity (GO:0060192)3.62597450
120regulation of fatty acid beta-oxidation (GO:0031998)3.60682877
121opsonization (GO:0008228)3.59676353
122cellular amino acid catabolic process (GO:0009063)3.59602676
123biotin metabolic process (GO:0006768)3.59282965
124protein activation cascade (GO:0072376)3.58762264
125neutrophil activation (GO:0042119)3.58735517
126cellular ketone body metabolic process (GO:0046950)3.55194147
127negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.50782124
128negative regulation of leukocyte mediated immunity (GO:0002704)3.48889557
129bile acid and bile salt transport (GO:0015721)3.48137728
130monocarboxylic acid catabolic process (GO:0072329)3.47776930
131regulation of cholesterol homeostasis (GO:2000188)3.47712961
132cholesterol efflux (GO:0033344)3.41629457
133negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.41416997
134leukocyte aggregation (GO:0070486)3.41100496
135regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.40725965
136positive regulation of fatty acid metabolic process (GO:0045923)3.40508632
137positive regulation of lipoprotein lipase activity (GO:0051006)3.39965998
138positive regulation of triglyceride lipase activity (GO:0061365)3.39965998
139short-chain fatty acid metabolic process (GO:0046459)3.39528460
140respiratory burst (GO:0045730)3.38620205
141negative regulation of sterol transport (GO:0032372)3.38156899
142negative regulation of cholesterol transport (GO:0032375)3.38156899
143cellular response to interleukin-15 (GO:0071350)3.37654721
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37559478
145carboxylic acid catabolic process (GO:0046395)3.37081134
146organic acid catabolic process (GO:0016054)3.37081134
147cholesterol homeostasis (GO:0042632)3.34590222
148positive regulation of triglyceride metabolic process (GO:0090208)3.34088217
149arginine metabolic process (GO:0006525)3.33896898
150regulation of plasminogen activation (GO:0010755)3.32089228
151cellular glucuronidation (GO:0052695)3.31679699
152regulation of triglyceride metabolic process (GO:0090207)3.31354971
153myeloid leukocyte mediated immunity (GO:0002444)3.30378648
154sterol homeostasis (GO:0055092)3.29681224
155positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.28996891
156plasma lipoprotein particle assembly (GO:0034377)3.28888846
157positive regulation of cellular amide metabolic process (GO:0034250)3.27143149
158negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.23016467
159dendritic cell migration (GO:0036336)3.18430411
160negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.18181321
161negative regulation of T-helper cell differentiation (GO:0045623)3.18181321
162myeloid cell activation involved in immune response (GO:0002275)3.16227707
163negative regulation of T cell mediated immunity (GO:0002710)3.14502381
164granulocyte activation (GO:0036230)3.13265188
165germinal center formation (GO:0002467)3.03799734
166positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00288236
167immunoglobulin mediated immune response (GO:0016064)2.99958015
168negative regulation of adaptive immune response (GO:0002820)2.98906544
169regulation of T-helper 2 cell differentiation (GO:0045628)2.97648103
170antigen processing and presentation via MHC class Ib (GO:0002475)2.96476194
171B cell receptor signaling pathway (GO:0050853)2.91483321
172negative regulation of type 2 immune response (GO:0002829)2.90067209
173response to type I interferon (GO:0034340)2.88433532
174regulation of tolerance induction (GO:0002643)2.87673780
175cellular response to type I interferon (GO:0071357)2.86567151
176type I interferon signaling pathway (GO:0060337)2.86567151
177T-helper 1 type immune response (GO:0042088)2.82650938
178dendritic cell chemotaxis (GO:0002407)2.81359561
179regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.81292822
180positive regulation of interferon-alpha production (GO:0032727)2.78321601
181regulation of interleukin-6 biosynthetic process (GO:0045408)2.76176913
182positive regulation of tolerance induction (GO:0002645)2.75779954
183cellular response to epinephrine stimulus (GO:0071872)2.75372042
184regulation of mast cell degranulation (GO:0043304)2.74753728
185regulation of regulatory T cell differentiation (GO:0045589)2.73075070
186neutrophil chemotaxis (GO:0030593)2.71636969
187defense response to protozoan (GO:0042832)2.70596937
188positive regulation of toll-like receptor signaling pathway (GO:0034123)2.70298955
189regulation of macrophage cytokine production (GO:0010935)2.67701709
190negative regulation of glycoprotein biosynthetic process (GO:0010561)2.67410137
191positive regulation of T cell mediated cytotoxicity (GO:0001916)2.64416365
192neutrophil migration (GO:1990266)2.64317029
193regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63862256
194regulation of necroptotic process (GO:0060544)2.63494999
195regulation of mast cell activation involved in immune response (GO:0033006)2.61508867
196regulation of T cell mediated cytotoxicity (GO:0001914)2.60497561
197regulation of mast cell activation (GO:0033003)2.60064429
198negative regulation of interleukin-6 production (GO:0032715)2.59333947
199I-kappaB phosphorylation (GO:0007252)2.58893990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.96736654
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.72116571
3RXR_22158963_ChIP-Seq_LIVER_Mouse7.03299939
4PPARA_22158963_ChIP-Seq_LIVER_Mouse6.04543134
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.65285227
6EGR1_23403033_ChIP-Seq_LIVER_Mouse5.38630499
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.47854006
8BP1_19119308_ChIP-ChIP_Hs578T_Human4.00402428
9* CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.94569666
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.90560006
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79457775
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65942854
13IRF8_21731497_ChIP-ChIP_J774_Mouse3.30032707
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.28997124
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.99634168
16CLOCK_20551151_ChIP-Seq_293T_Human2.88835429
17* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.82272976
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.71643790
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64374496
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.62433815
21RUNX_20019798_ChIP-Seq_JUKART_Human2.57584799
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38803781
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.25829662
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19625501
25NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18646053
26SPI1_23127762_ChIP-Seq_K562_Human2.01523809
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99991952
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86216619
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85794875
30SCL_19346495_ChIP-Seq_HPC-7_Human1.84393246
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.82211112
32TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.79756367
33GATA1_22025678_ChIP-Seq_K562_Human1.76657643
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73130099
35MYB_26560356_Chip-Seq_TH2_Human1.65506870
36SPI1_23547873_ChIP-Seq_NB4_Human1.62356475
37VDR_24763502_ChIP-Seq_THP-1_Human1.59586144
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.57649342
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.57072947
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55459622
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50681197
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46574515
43* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44969264
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44513063
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41474599
46GATA3_27048872_Chip-Seq_THYMUS_Human1.39143859
47* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36026317
48MYB_26560356_Chip-Seq_TH1_Human1.33820569
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32802064
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.31756234
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30763969
52E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29482342
53TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27666171
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.25834917
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24920701
56MAF_26560356_Chip-Seq_TH1_Human1.24196674
57TP63_17297297_ChIP-ChIP_HaCaT_Human1.24099219
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.23872808
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23468005
60* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20919923
61GATA3_26560356_Chip-Seq_TH2_Human1.20693730
62HNF4A_19822575_ChIP-Seq_HepG2_Human1.17512609
63IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16691067
64PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.14148545
65ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12063012
66PU_27001747_Chip-Seq_BMDM_Mouse1.11775275
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09267279
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.08782902
69TCF7_22412390_ChIP-Seq_EML_Mouse1.08519966
70AHR_22903824_ChIP-Seq_MCF-7_Human1.08350495
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.06225084
72CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05711035
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05710674
74TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04128590
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03976631
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.03883222
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03353478
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03051790
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02951948
80LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01536594
81UTX_26944678_Chip-Seq_JUKART_Human1.00890519
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00427871
83FOXO3_23340844_ChIP-Seq_DLD1_Human1.00061688
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.99687354
85SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98160720
86PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.98123593
87RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97507782
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97111228
89NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97111228
90HTT_18923047_ChIP-ChIP_STHdh_Human0.97074579
91SMRT_27268052_Chip-Seq_Bcells_Human0.95008768
92NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94401230
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94040764
94ZNF263_19887448_ChIP-Seq_K562_Human0.92687186
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91946297
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91677686
97CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91042720
98SALL4_18804426_ChIP-ChIP_XEN_Mouse0.90377820
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.89586399
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88146688
101VDR_21846776_ChIP-Seq_THP-1_Human0.87647482
102EGR1_19374776_ChIP-ChIP_THP-1_Human0.87164340
103DROSHA_22980978_ChIP-Seq_HELA_Human0.86826315
104VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86593313
105ESR1_20079471_ChIP-ChIP_T-47D_Human0.85866537
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83512291
107GATA4_25053715_ChIP-Seq_YYC3_Human0.82948246
108RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82183106
109GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82056338
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81893820
111* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81282358
112TBX20_22328084_ChIP-Seq_HEART_Mouse0.80092653
113TBX20_22080862_ChIP-Seq_HEART_Mouse0.80092653
114GATA2_21666600_ChIP-Seq_HMVEC_Human0.80092475
115KDM2B_26808549_Chip-Seq_DND41_Human0.78791507
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.78022296
117AUTS2_25519132_ChIP-Seq_293T-REX_Human0.77881700
118TP53_16413492_ChIP-PET_HCT116_Human0.76610679
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75726816
120ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73520891
121CJUN_26792858_Chip-Seq_BT549_Human0.72913571
122* SOX2_20726797_ChIP-Seq_SW620_Human0.71849870
123* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71608391
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.68245076
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.66377353
126* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.65577529
127LXR_22292898_ChIP-Seq_THP-1_Human0.63816900
128SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62696009
129PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.61663466
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.61107138
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60756518
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.59670095
133BCAT_22108803_ChIP-Seq_LS180_Human0.58641473
134EGR1_19032775_ChIP-ChIP_M12_Human0.58598546
135FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58279573
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.58011685
137CEBPB_22108803_ChIP-Seq_LS180_Human0.57592252
138GATA1_19941826_ChIP-Seq_K562_Human0.57509641
139RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56793693
140GATA2_19941826_ChIP-Seq_K562_Human0.56792837
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.56172381
142* FOXA1_25552417_ChIP-Seq_VCAP_Human0.55777294
143CDX2_19796622_ChIP-Seq_MESCs_Mouse0.55201458
144GATA3_24758297_ChIP-Seq_MCF-7_Human0.54791322
145* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.54107186
146ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.53679801
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52623498
148ZNF217_24962896_ChIP-Seq_MCF-7_Human0.51814749
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51694172
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.51664363
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.51185189
152RACK7_27058665_Chip-Seq_MCF-7_Human0.50783262
153TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.49463187
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.49443094
155VDR_24787735_ChIP-Seq_THP-1_Human0.49146852
156BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.48614045
157PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.48488824
158PIAS1_25552417_ChIP-Seq_VCAP_Human0.47621798
159TP63_23658742_ChIP-Seq_EP156T_Human0.45954374
160RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.45285907
161CSB_26484114_Chip-Seq_FIBROBLAST_Human0.45266597
162AR_20517297_ChIP-Seq_VCAP_Human0.44775395

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.51588395
2MP0005360_urolithiasis6.10282493
3MP0005365_abnormal_bile_salt5.10743465
4MP0005085_abnormal_gallbladder_physiolo5.00128069
5MP0008875_abnormal_xenobiotic_pharmacok3.89747691
6MP0010329_abnormal_lipoprotein_level3.73597725
7MP0005670_abnormal_white_adipose3.26401444
8MP0003303_peritoneal_inflammation3.09376901
9MP0003252_abnormal_bile_duct3.07371361
10MP0003191_abnormal_cellular_cholesterol3.06342678
11MP0001835_abnormal_antigen_presentation3.03714263
12MP0003806_abnormal_nucleotide_metabolis3.03252015
13MP0002419_abnormal_innate_immunity2.77828932
14MP0009785_altered_susceptibility_to2.54420825
15MP0003828_pulmonary_edema2.51334552
16MP0009840_abnormal_foam_cell2.50605198
17MP0005025_abnormal_response_to2.38797422
18MP0000685_abnormal_immune_system2.37792107
19MP0001800_abnormal_humoral_immune2.36796286
20MP0005332_abnormal_amino_acid2.32286833
21MP0005387_immune_system_phenotype2.31618414
22MP0001790_abnormal_immune_system2.31618414
23MP0004130_abnormal_muscle_cell2.31111994
24MP0002118_abnormal_lipid_homeostasis2.25926793
25MP0005083_abnormal_biliary_tract2.25713806
26MP0003705_abnormal_hypodermis_morpholog2.21174997
27MP0005666_abnormal_adipose_tissue2.19768009
28MP0000609_abnormal_liver_physiology2.17300893
29MP0005000_abnormal_immune_tolerance2.13228564
30MP0003195_calcinosis2.10898148
31MP0002723_abnormal_immune_serum2.08765751
32MP0002132_abnormal_respiratory_system2.03666614
33MP0001666_abnormal_nutrient_absorption1.99511726
34MP0002452_abnormal_antigen_presenting1.99229940
35MP0008438_abnormal_cutaneous_collagen1.96164431
36MP0004381_abnormal_hair_follicle1.95110534
37MP0002420_abnormal_adaptive_immunity1.95010553
38MP0008260_abnormal_autophagy1.94860614
39MP0002254_reproductive_system_inflammat1.92776637
40MP0001819_abnormal_immune_cell1.92696768
41MP0000569_abnormal_digit_pigmentation1.90449600
42MP0006082_CNS_inflammation1.90039058
43MP0005671_abnormal_response_to1.87031454
44MP0004185_abnormal_adipocyte_glucose1.86515754
45MP0002405_respiratory_system_inflammati1.86142776
46MP0002277_abnormal_respiratory_mucosa1.77822773
47MP0005319_abnormal_enzyme/_coenzyme1.75111949
48MP0008004_abnormal_stomach_pH1.73234239
49MP0002148_abnormal_hypersensitivity_rea1.70945172
50MP0004019_abnormal_vitamin_homeostasis1.67082133
51MP0000465_gastrointestinal_hemorrhage1.66291554
52MP0002971_abnormal_brown_adipose1.63765985
53MP0001958_emphysema1.61571211
54MP0002837_dystrophic_cardiac_calcinosis1.61564106
55MP0003763_abnormal_thymus_physiology1.57448982
56MP0002876_abnormal_thyroid_physiology1.55063477
57MP0004947_skin_inflammation1.53807541
58MP0005375_adipose_tissue_phenotype1.52512514
59MP0001845_abnormal_inflammatory_respons1.48999872
60MP0005275_abnormal_skin_tensile1.47183764
61MP0001851_eye_inflammation1.46521132
62MP0005584_abnormal_enzyme/coenzyme_acti1.46399489
63MP0003186_abnormal_redox_activity1.42792752
64MP0002998_abnormal_bone_remodeling1.41178871
65MP0004484_altered_response_of1.40377625
66MP0001661_extended_life_span1.38974753
67MP0000716_abnormal_immune_system1.38837763
68MP0001764_abnormal_homeostasis1.38799109
69MP0010155_abnormal_intestine_physiology1.36000287
70MP0002138_abnormal_hepatobiliary_system1.35948304
71MP0005464_abnormal_platelet_physiology1.35326159
72MP0005334_abnormal_fat_pad1.34421865
73MP0003724_increased_susceptibility_to1.32745809
74MP0003866_abnormal_defecation1.30789145
75MP0003045_fibrosis1.30634750
76MP0002398_abnormal_bone_marrow1.27768261
77MP0010368_abnormal_lymphatic_system1.23666413
78MP0009643_abnormal_urine_homeostasis1.21422139
79MP0009115_abnormal_fat_cell1.21400990
80MP0005397_hematopoietic_system_phenotyp1.19521701
81MP0001545_abnormal_hematopoietic_system1.19521701
82MP0003868_abnormal_feces_composition1.18572836
83MP0000858_altered_metastatic_potential1.15729858
84MP0009763_increased_sensitivity_to1.14665767
85MP0009278_abnormal_bone_marrow1.13264089
86MP0009764_decreased_sensitivity_to1.12549878
87MP0002722_abnormal_immune_system1.11783890
88MP0005388_respiratory_system_phenotype1.11237203
89MP0002133_abnormal_respiratory_system1.11237203
90MP0000689_abnormal_spleen_morphology1.10556201
91MP0000598_abnormal_liver_morphology1.09262053
92MP0003011_delayed_dark_adaptation1.08316936
93MP0003183_abnormal_peptide_metabolism1.08103683
94MP0003172_abnormal_lysosome_physiology1.05922083
95MP0005647_abnormal_sex_gland1.05082987
96MP0005310_abnormal_salivary_gland1.04396417
97MP0003690_abnormal_glial_cell1.04390298
98MP0004272_abnormal_basement_membrane1.01504038
99MP0002332_abnormal_exercise_endurance1.01461977
100MP0000604_amyloidosis1.01285258
101MP0005535_abnormal_body_temperature1.01256312
102MP0002429_abnormal_blood_cell1.00664894
103MP0000013_abnormal_adipose_tissue1.00029073
104MP0005166_decreased_susceptibility_to0.99175852
105MP0002060_abnormal_skin_morphology0.96314370
106MP0002078_abnormal_glucose_homeostasis0.95533585
107MP0009697_abnormal_copulation0.94126238
108MP0000703_abnormal_thymus_morphology0.93374764
109MP0000003_abnormal_adipose_tissue0.93050803
110MP0002006_tumorigenesis0.92100565
111MP0002970_abnormal_white_adipose0.91900613
112MP0002396_abnormal_hematopoietic_system0.89669754
113MP0001881_abnormal_mammary_gland0.88750780
114MP0003656_abnormal_erythrocyte_physiolo0.88019442
115MP0005448_abnormal_energy_balance0.87528390
116MP0005390_skeleton_phenotype0.87329062
117MP0008469_abnormal_protein_level0.86287426
118MP0002796_impaired_skin_barrier0.86138147
119MP0003448_altered_tumor_morphology0.83407949
120MP0003091_abnormal_cell_migration0.81241150
121MP0005164_abnormal_response_to0.80753805
122MP0005023_abnormal_wound_healing0.80718803
123MP0009642_abnormal_blood_homeostasis0.76561459
124MP0005376_homeostasis/metabolism_phenot0.76211754
125MP0001756_abnormal_urination0.76192625
126MP0005451_abnormal_body_composition0.75000539
127MP0003959_abnormal_lean_body0.74682510
128MP0005167_abnormal_blood-brain_barrier0.74076688
129MP0006036_abnormal_mitochondrial_physio0.74020381
130MP0003221_abnormal_cardiomyocyte_apopto0.73426659
131MP0004510_myositis0.71318710
132MP0003795_abnormal_bone_structure0.69484538
133MP0009765_abnormal_xenobiotic_induced0.68663750
134MP0002909_abnormal_adrenal_gland0.67861306
135MP0009333_abnormal_splenocyte_physiolog0.66544266
136MP0003075_altered_response_to0.65680702
137MP0004808_abnormal_hematopoietic_stem0.63799951
138MP0000015_abnormal_ear_pigmentation0.63591274
139MP0009384_cardiac_valve_regurgitation0.62546414
140MP0002933_joint_inflammation0.62430302
141MP0005636_abnormal_mineral_homeostasis0.62037140
142MP0003279_aneurysm0.61969197
143MP0005174_abnormal_tail_pigmentation0.61709237
144MP0002168_other_aberrant_phenotype0.61577246
145MP0002009_preneoplasia0.61092996
146MP0002295_abnormal_pulmonary_circulatio0.59545772
147MP0010234_abnormal_vibrissa_follicle0.58620696
148MP0000343_altered_response_to0.58361356
149MP0000249_abnormal_blood_vessel0.57893101
150MP0003436_decreased_susceptibility_to0.57502477
151MP0003566_abnormal_cell_adhesion0.56112937
152MP0000427_abnormal_hair_cycle0.55894948
153MP0005266_abnormal_metabolism0.53085925
154MP0004883_abnormal_blood_vessel0.52720008
155MP0005595_abnormal_vascular_smooth0.52571811
156MP0005220_abnormal_exocrine_pancreas0.52154668
157MP0003300_gastrointestinal_ulcer0.52051168
158MP0006138_congestive_heart_failure0.51406440
159MP0000579_abnormal_nail_morphology0.51252612
160MP0002136_abnormal_kidney_physiology0.51093584
161MP0001853_heart_inflammation0.50064265
162MP0005452_abnormal_adipose_tissue0.50063011
163MP0000230_abnormal_systemic_arterial0.49888278
164MP0008775_abnormal_heart_ventricle0.49739594
165MP0001533_abnormal_skeleton_physiology0.48336792
166MP0002166_altered_tumor_susceptibility0.48268012
167MP0001243_abnormal_dermal_layer0.46824733
168MP0004782_abnormal_surfactant_physiolog0.46785929
169MP0003453_abnormal_keratinocyte_physiol0.45751891
170MP0003953_abnormal_hormone_level0.45381900

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.50752928
2Eczematoid dermatitis (HP:0000976)6.45699025
3Complement deficiency (HP:0004431)6.41737772
4Intrahepatic cholestasis (HP:0001406)5.80281264
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.79500990
6Xanthomatosis (HP:0000991)5.75492154
7Orchitis (HP:0100796)5.72012523
8Myositis (HP:0100614)5.69699530
9Retrobulbar optic neuritis (HP:0100654)5.42079678
10Optic neuritis (HP:0100653)5.42079678
11Hyperlipoproteinemia (HP:0010980)5.36102791
12Prolonged partial thromboplastin time (HP:0003645)5.34305134
13Recurrent bacterial skin infections (HP:0005406)5.28067978
14Recurrent abscess formation (HP:0002722)5.25274799
15Abnormality of monocarboxylic acid metabolism (HP:0010996)5.19312500
16Hypobetalipoproteinemia (HP:0003563)4.82499739
17Abnormality of complement system (HP:0005339)4.70372550
18Hypoalphalipoproteinemia (HP:0003233)4.58862623
19Abnormality of the common coagulation pathway (HP:0010990)4.58851275
20Epidermoid cyst (HP:0200040)4.48317320
21Keratoconjunctivitis sicca (HP:0001097)4.41709821
22Hypolipoproteinemia (HP:0010981)4.40209009
23Hyperammonemia (HP:0001987)4.30953850
24Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.26455417
25Hyperglycinuria (HP:0003108)4.24020455
26Gastrointestinal infarctions (HP:0005244)4.10883218
27Ketosis (HP:0001946)4.10437933
28Keratoconjunctivitis (HP:0001096)4.09639875
29Hypoglycemic coma (HP:0001325)4.06799170
30Hyperglycinemia (HP:0002154)4.04418386
31Elevated erythrocyte sedimentation rate (HP:0003565)4.04163220
32Abnormality of glycine metabolism (HP:0010895)4.02033279
33Abnormality of serine family amino acid metabolism (HP:0010894)4.02033279
34Joint hemorrhage (HP:0005261)3.98924128
35Abnormality of macrophages (HP:0004311)3.98413978
36Stomatitis (HP:0010280)3.89627355
37Abnormality of glutamine family amino acid metabolism (HP:0010902)3.85719547
38Spontaneous hematomas (HP:0007420)3.80550505
39Gingivitis (HP:0000230)3.72864529
40Recurrent fungal infections (HP:0002841)3.63990533
41Increased IgE level (HP:0003212)3.55383693
42Abnormality of fatty-acid metabolism (HP:0004359)3.54677002
43Spontaneous abortion (HP:0005268)3.53339518
44Myocardial infarction (HP:0001658)3.52058247
45Recurrent skin infections (HP:0001581)3.49354144
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42775986
47Interstitial pulmonary disease (HP:0006530)3.39768099
48Abnormality of the intrinsic pathway (HP:0010989)3.39515624
49Systemic lupus erythematosus (HP:0002725)3.37725024
50Hypercholesterolemia (HP:0003124)3.36627910
51Mediastinal lymphadenopathy (HP:0100721)3.34314555
52Abnormality of aspartate family amino acid metabolism (HP:0010899)3.27396291
53Abnormality of sulfur amino acid metabolism (HP:0004339)3.27315730
54Fat malabsorption (HP:0002630)3.26514328
55Abnormal delayed hypersensitivity skin test (HP:0002963)3.26199575
56Ketoacidosis (HP:0001993)3.19676418
57Abnormality of methionine metabolism (HP:0010901)3.16400600
58Arterial thrombosis (HP:0004420)3.15275048
59Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.11852049
60Hemoptysis (HP:0002105)3.08223861
61Meningitis (HP:0001287)3.07781912
62Encephalitis (HP:0002383)3.05869579
63Recurrent cutaneous fungal infections (HP:0011370)3.02315280
64Chronic mucocutaneous candidiasis (HP:0002728)3.02315280
65Skin nodule (HP:0200036)3.02095327
66Abnormality of T cell number (HP:0011839)3.01161009
67T lymphocytopenia (HP:0005403)3.00823531
68Urticaria (HP:0001025)2.99772176
69Amyloidosis (HP:0011034)2.99428667
70Vasculitis (HP:0002633)2.98632084
71Hypertriglyceridemia (HP:0002155)2.93189649
72Chest pain (HP:0100749)2.92790582
73Obstructive lung disease (HP:0006536)2.92375058
74Chronic obstructive pulmonary disease (HP:0006510)2.92375058
75Pulmonary embolism (HP:0002204)2.74380774
76Episodic fever (HP:0001954)2.74246784
77Oligomenorrhea (HP:0000876)2.73579927
78Pulmonary infiltrates (HP:0002113)2.72645691
79Prolonged bleeding time (HP:0003010)2.68768364
80Abnormality of serum amino acid levels (HP:0003112)2.67328652
81Gangrene (HP:0100758)2.66471546
82Hemorrhage of the eye (HP:0011885)2.65577289
83Conjugated hyperbilirubinemia (HP:0002908)2.60988565
84Abnormality of purine metabolism (HP:0004352)2.60184139
85Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58838484
86Dicarboxylic aciduria (HP:0003215)2.58838484
87Abnormality of proline metabolism (HP:0010907)2.58187229
88Hydroxyprolinuria (HP:0003080)2.58187229
89Abnormality of nucleobase metabolism (HP:0010932)2.57933786
90Leukocytosis (HP:0001974)2.57533615
91Hepatocellular carcinoma (HP:0001402)2.56954726
92Anorexia (HP:0002039)2.56869416
93Recurrent gram-negative bacterial infections (HP:0005420)2.54950855
94Abnormality of pyrimidine metabolism (HP:0004353)2.53433078
95Delayed CNS myelination (HP:0002188)2.49265947
96Hypochromic anemia (HP:0001931)2.47500489
97Acanthosis nigricans (HP:0000956)2.47003072
98Hyperbilirubinemia (HP:0002904)2.46737427
99Steatorrhea (HP:0002570)2.44247995
100Neoplasm of the tracheobronchial system (HP:0100552)2.42822440
101Cellulitis (HP:0100658)2.41988737
102Gingival bleeding (HP:0000225)2.38694698
103Glomerulonephritis (HP:0000099)2.36229838
104Muscle fiber splitting (HP:0003555)2.35904134
105Mitral stenosis (HP:0001718)2.35898421
106Abnormality of the peritoneum (HP:0002585)2.35693388
107Epistaxis (HP:0000421)2.34937196
108Metabolic acidosis (HP:0001942)2.34207475
109Subacute progressive viral hepatitis (HP:0006572)2.31521963
110Papilledema (HP:0001085)2.30965066
111Esophageal varix (HP:0002040)2.30543102
112Abnormality of the endocardium (HP:0004306)2.29940134
113Pancreatitis (HP:0001733)2.28982060
114Lethargy (HP:0001254)2.28667306
115Hypoglycemic seizures (HP:0002173)2.28095058
116Abnormal cartilage morphology (HP:0002763)2.27552170
117Recurrent bronchitis (HP:0002837)2.27503670
118Difficulty running (HP:0009046)2.27354209
119Alveolar cell carcinoma (HP:0006519)2.25884225
120Abnormality of the pleura (HP:0002103)2.24270933
121Osteomyelitis (HP:0002754)2.22523038
122Spastic diplegia (HP:0001264)2.22090257
123Metaphyseal cupping (HP:0003021)2.18044476
124Eosinophilia (HP:0001880)2.17443322
125Hyperglycemia (HP:0003074)2.17172944
126Abnormality of T cells (HP:0002843)2.16447504
127Granulocytopenia (HP:0001913)2.13979912
128Cholelithiasis (HP:0001081)2.12634386
129Abnormal gallbladder morphology (HP:0012437)2.11706367
130Myoglobinuria (HP:0002913)2.09429516
131Facial diplegia (HP:0001349)2.09126594
132Vascular calcification (HP:0004934)2.08763399
133Microcytic anemia (HP:0001935)2.08623149
134Cardiovascular calcification (HP:0011915)2.08545307
135Inflammation of the large intestine (HP:0002037)2.08252751
136Thrombophlebitis (HP:0004418)2.07209886
137Keratitis (HP:0000491)2.06190074
138Absent/shortened dynein arms (HP:0200106)2.05852335
139Dynein arm defect of respiratory motile cilia (HP:0012255)2.05852335
140Nephritis (HP:0000123)2.05774454
141Nausea (HP:0002018)2.05300246
142Vertigo (HP:0002321)2.05201611
143Cerebral edema (HP:0002181)2.04884987
144Abnormality of the fingertips (HP:0001211)2.04168808
145Acne (HP:0001061)2.04165175
146Hypochromic microcytic anemia (HP:0004840)2.02458717
147Pigmentary retinal degeneration (HP:0001146)2.01530913
148Right ventricular cardiomyopathy (HP:0011663)2.01475238
149Pustule (HP:0200039)1.99454756
150Hypergammaglobulinemia (HP:0010702)1.99237051
151Neonatal onset (HP:0003623)1.98910313
152Ventricular fibrillation (HP:0001663)1.97653471
153Generalized aminoaciduria (HP:0002909)1.96236306
154Vomiting (HP:0002013)1.95806417
155Brushfield spots (HP:0001088)1.95567410
156Acute hepatic failure (HP:0006554)1.93693748
157Segmental peripheral demyelination/remyelination (HP:0003481)1.91319569
158Slow saccadic eye movements (HP:0000514)1.91011381
159Peritonitis (HP:0002586)1.90241483
160Decreased circulating renin level (HP:0003351)1.89946354
161Nasal polyposis (HP:0100582)1.89354170
162Abnormality of the pericardium (HP:0001697)1.89043219
163Hyporeflexia of lower limbs (HP:0002600)1.87878455
164Gastrointestinal inflammation (HP:0004386)1.86638041
165Late onset (HP:0003584)1.85185724
166Toxemia of pregnancy (HP:0100603)1.83633557
167Irritability (HP:0000737)1.83096549
168Insulin resistance (HP:0000855)1.82360810
169Cheilitis (HP:0100825)1.82237781
170Recurrent viral infections (HP:0004429)1.81938410
171Gout (HP:0001997)1.81789169
172Hyperinsulinemic hypoglycemia (HP:0000825)1.80871276
173Sensorimotor neuropathy (HP:0007141)1.79142184
174Sepsis (HP:0100806)1.78630864
175Stomach cancer (HP:0012126)1.78199768
176Abnormality of iron homeostasis (HP:0011031)1.78164127
177Chronic otitis media (HP:0000389)1.77963723
178Ectopia lentis (HP:0001083)1.76520795
179Glomerulopathy (HP:0100820)1.76053077
180Abnormality of the nasal mucosa (HP:0000433)1.75781645
181Skin ulcer (HP:0200042)1.74855246
182Abnormality of eosinophils (HP:0001879)1.74143277
183Abnormal gallbladder physiology (HP:0012438)1.73904630
184Cholecystitis (HP:0001082)1.73904630
185Bronchitis (HP:0012387)1.73719595
186Aortic aneurysm (HP:0004942)1.73560145
187Hematochezia (HP:0002573)1.73457337
188Stroke (HP:0001297)1.73253367
189Abnormality of transition element cation homeostasis (HP:0011030)1.73005719
190Acanthocytosis (HP:0001927)1.72435392
191Elevated hepatic transaminases (HP:0002910)1.68461101
192Polycythemia (HP:0001901)1.68446456
193Malnutrition (HP:0004395)1.67926265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.17510425
2ERN14.90231240
3SIK14.30806666
4RIPK43.95709972
5FGFR43.77609791
6TRIB33.40689708
7BLK3.15689874
8CAMK1D2.90454959
9IRAK42.81100802
10MST1R2.36678226
11INSRR2.31384662
12FRK1.98463303
13FES1.97159841
14EPHA31.94578297
15ERBB41.92511030
16CAMK1G1.92239671
17MAP4K11.89948647
18LATS11.89687947
19ZAP701.85289718
20RIPK11.78420652
21EPHB11.74914046
22PDGFRA1.63788456
23FGFR21.59011561
24FGFR31.57038516
25YES11.54188430
26TXK1.52565428
27TNK21.51648396
28NEK91.50321611
29PKN21.50216105
30HCK1.48410965
31TYK21.46189619
32AKT31.44799020
33PRKAA21.42550419
34MYLK1.38863816
35MAPK111.37545898
36PTK61.36555423
37BTK1.35679697
38JAK11.35312162
39TIE11.33906019
40TAOK31.30249513
41PIK3CG1.29196965
42TAOK11.28431108
43FGR1.27778996
44TGFBR21.27377722
45FLT31.24704918
46JAK21.23424548
47PDK31.20575957
48PDK41.20575957
49MET1.20106898
50SYK1.19726995
51KSR21.19187394
52MAP2K41.18573175
53EPHB21.15617923
54ABL21.10678012
55MARK21.10222344
56TTN1.08854019
57LYN1.06859379
58MAP3K31.06618720
59FER1.04758233
60MAP3K131.04520407
61KDR1.04146480
62SGK21.03056337
63PTK2B1.02324390
64MATK0.98251836
65IRAK20.97378502
66DAPK20.97325994
67DDR20.97228255
68WNK10.96833842
69CDK60.95817339
70LRRK20.95618688
71PIK3CA0.92985885
72BMPR20.91954167
73MAP2K30.91456931
74STK380.85954833
75KIT0.85068269
76MAP2K10.83763680
77PRPF4B0.82903312
78LCK0.82785427
79MAP3K70.81654132
80OXSR10.80667480
81TEC0.79115812
82PDK20.78734348
83ITK0.78579559
84LMTK20.77003966
85MARK30.76127206
86STK100.74174152
87STK110.73575693
88MAP3K110.73458052
89MAP3K50.73214272
90TBK10.71819753
91ACVR1B0.70652672
92GSK3A0.68848602
93PRKAA10.68814855
94SGK4940.64247544
95SGK2230.64247544
96CDC42BPA0.63829945
97RET0.63232505
98ERBB20.62419846
99MAPK40.62172640
100MAPK120.62016673
101IRAK10.61338724
102CAMKK20.60996706
103MAP2K60.60463729
104PRKACG0.60373231
105CSK0.60347726
106RAF10.60048495
107HIPK20.60004063
108TRPM70.59425757
109NLK0.57505363
110CDK90.55287782
111MAP3K100.55067013
112PDPK10.53770612
113PDGFRB0.53740064
114IGF1R0.53661173
115MAP3K140.52953485
116PINK10.52736904
117MTOR0.52052354
118PRKD20.51244555
119STK38L0.50933000
120PTK20.50667560
121JAK30.49712317
122FYN0.49178779
123LATS20.49166563
124ADRBK10.47532515
125NEK60.47490248
126IKBKB0.47169984
127MAP3K60.45367458
128PAK30.45194995
129MELK0.43401582
130IRAK30.42739200
131PAK20.41608821
132CAMK2G0.40578346
133PRKCZ0.40015228
134IKBKE0.39513130
135PRKD10.39023291
136OBSCN0.38879352
137SGK30.36323190
138STK30.35665311
139FGFR10.34230244
140BMX0.33752863
141PRKCH0.32299625
142MAP3K10.32204052
143GRK60.31275219
144DYRK1B0.31023321
145CSF1R0.30836164
146MAPK70.30374056
147MAP3K20.29609423
148ABL10.28481036
149INSR0.28329637
150PHKG20.27307543
151PHKG10.27307543
152CDK40.26936159
153PDK10.25555666

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.05980418
2Nitrogen metabolism_Homo sapiens_hsa009103.53688464
3Complement and coagulation cascades_Homo sapiens_hsa046102.94403209
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.93253005
5Arginine biosynthesis_Homo sapiens_hsa002202.90843657
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.77523922
7Fatty acid degradation_Homo sapiens_hsa000712.77093366
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74923062
9Leishmaniasis_Homo sapiens_hsa051402.71102172
10Osteoclast differentiation_Homo sapiens_hsa043802.65623330
11PPAR signaling pathway_Homo sapiens_hsa033202.60546673
12Propanoate metabolism_Homo sapiens_hsa006402.58986592
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55721512
14Tryptophan metabolism_Homo sapiens_hsa003802.47051053
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37300475
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23816188
17Fatty acid metabolism_Homo sapiens_hsa012122.23665700
18Caffeine metabolism_Homo sapiens_hsa002322.14763894
19Staphylococcus aureus infection_Homo sapiens_hsa051502.09262820
20Peroxisome_Homo sapiens_hsa041462.06619400
21Tuberculosis_Homo sapiens_hsa051521.97352913
22Butanoate metabolism_Homo sapiens_hsa006501.96812692
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90274071
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89504164
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88091064
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84699593
27beta-Alanine metabolism_Homo sapiens_hsa004101.83703147
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.79670463
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.79630305
30B cell receptor signaling pathway_Homo sapiens_hsa046621.77736860
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76366720
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72575949
33Chemical carcinogenesis_Homo sapiens_hsa052041.70345062
34Phenylalanine metabolism_Homo sapiens_hsa003601.67811963
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.67579898
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.64903409
37Graft-versus-host disease_Homo sapiens_hsa053321.61381134
38Pyruvate metabolism_Homo sapiens_hsa006201.59131278
39Histidine metabolism_Homo sapiens_hsa003401.57919150
40Measles_Homo sapiens_hsa051621.57502873
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53899566
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.53323788
43Tyrosine metabolism_Homo sapiens_hsa003501.51295034
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50756780
45Chemokine signaling pathway_Homo sapiens_hsa040621.48024089
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.44992459
47Allograft rejection_Homo sapiens_hsa053301.44488031
48Acute myeloid leukemia_Homo sapiens_hsa052211.43566600
49Toxoplasmosis_Homo sapiens_hsa051451.42774776
50Hematopoietic cell lineage_Homo sapiens_hsa046401.41894789
51Retinol metabolism_Homo sapiens_hsa008301.39461980
52Autoimmune thyroid disease_Homo sapiens_hsa053201.39300207
53Fatty acid biosynthesis_Homo sapiens_hsa000611.37821422
54Legionellosis_Homo sapiens_hsa051341.37371912
55Fat digestion and absorption_Homo sapiens_hsa049751.36780522
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.35881632
57Phagosome_Homo sapiens_hsa041451.33970683
58Dorso-ventral axis formation_Homo sapiens_hsa043201.31909479
59Influenza A_Homo sapiens_hsa051641.31000331
60Carbon metabolism_Homo sapiens_hsa012001.29683802
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28972026
62TNF signaling pathway_Homo sapiens_hsa046681.28917357
63NF-kappa B signaling pathway_Homo sapiens_hsa040641.28536892
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28506822
65Platelet activation_Homo sapiens_hsa046111.28434248
66Bile secretion_Homo sapiens_hsa049761.26555737
67Leukocyte transendothelial migration_Homo sapiens_hsa046701.25544562
68T cell receptor signaling pathway_Homo sapiens_hsa046601.25497848
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25115004
70Starch and sucrose metabolism_Homo sapiens_hsa005001.22560588
71Sulfur metabolism_Homo sapiens_hsa009201.22483879
72Fatty acid elongation_Homo sapiens_hsa000621.21817960
73Selenocompound metabolism_Homo sapiens_hsa004501.19921342
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19864003
75ABC transporters_Homo sapiens_hsa020101.19643395
76Glycerolipid metabolism_Homo sapiens_hsa005611.16351471
77Non-small cell lung cancer_Homo sapiens_hsa052231.09958630
78Biosynthesis of amino acids_Homo sapiens_hsa012301.08227349
79Prolactin signaling pathway_Homo sapiens_hsa049171.07658916
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06825815
81Viral myocarditis_Homo sapiens_hsa054161.03999752
82FoxO signaling pathway_Homo sapiens_hsa040681.03464917
83Cysteine and methionine metabolism_Homo sapiens_hsa002701.01473606
84Primary immunodeficiency_Homo sapiens_hsa053401.00428501
85Pancreatic cancer_Homo sapiens_hsa052120.99431019
86Type I diabetes mellitus_Homo sapiens_hsa049400.99295068
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99253092
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98416366
89Renal cell carcinoma_Homo sapiens_hsa052110.97188770
90Hepatitis B_Homo sapiens_hsa051610.96567093
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94916547
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93871428
93Antigen processing and presentation_Homo sapiens_hsa046120.90282113
94Folate biosynthesis_Homo sapiens_hsa007900.89235712
95Vitamin B6 metabolism_Homo sapiens_hsa007500.88409433
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88287477
97Herpes simplex infection_Homo sapiens_hsa051680.87957224
98VEGF signaling pathway_Homo sapiens_hsa043700.85543833
99Apoptosis_Homo sapiens_hsa042100.81898094
100Chronic myeloid leukemia_Homo sapiens_hsa052200.79793060
101Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79209616
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.79031557
103Lysine degradation_Homo sapiens_hsa003100.76339159
104Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75375775
105Sulfur relay system_Homo sapiens_hsa041220.74644946
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74578356
107Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74380374
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.74010308
109Arginine and proline metabolism_Homo sapiens_hsa003300.72996869
110Choline metabolism in cancer_Homo sapiens_hsa052310.72921662
111GnRH signaling pathway_Homo sapiens_hsa049120.71553091
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70018269
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.68400111
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.67812052
115Vitamin digestion and absorption_Homo sapiens_hsa049770.67676735
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.66030694
117Endometrial cancer_Homo sapiens_hsa052130.65874612
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65114740
119Notch signaling pathway_Homo sapiens_hsa043300.65101551
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.64765806
121Steroid biosynthesis_Homo sapiens_hsa001000.64252735
122mTOR signaling pathway_Homo sapiens_hsa041500.63876455
123Pentose phosphate pathway_Homo sapiens_hsa000300.63862395
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62487608
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.62071850
126Insulin resistance_Homo sapiens_hsa049310.62029968
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61633057
128Endocytosis_Homo sapiens_hsa041440.61298558
129Salmonella infection_Homo sapiens_hsa051320.61024619
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60943891
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60553892
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.59875565
133Prostate cancer_Homo sapiens_hsa052150.58400365
134Glutathione metabolism_Homo sapiens_hsa004800.55810905
135Inositol phosphate metabolism_Homo sapiens_hsa005620.55057381
136MAPK signaling pathway_Homo sapiens_hsa040100.52375256
137HIF-1 signaling pathway_Homo sapiens_hsa040660.49916829
138Rheumatoid arthritis_Homo sapiens_hsa053230.49696077
139Lysosome_Homo sapiens_hsa041420.49466795
140AMPK signaling pathway_Homo sapiens_hsa041520.48964959
141Prion diseases_Homo sapiens_hsa050200.48384210
142Asthma_Homo sapiens_hsa053100.48264615
143Rap1 signaling pathway_Homo sapiens_hsa040150.47982397
144Regulation of autophagy_Homo sapiens_hsa041400.46641356
145Estrogen signaling pathway_Homo sapiens_hsa049150.45486309
146ErbB signaling pathway_Homo sapiens_hsa040120.40954652
147SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40000008
148Metabolic pathways_Homo sapiens_hsa011000.35402382
149alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32516276
150Glucagon signaling pathway_Homo sapiens_hsa049220.31335882
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.24536701
152One carbon pool by folate_Homo sapiens_hsa006700.21755051
153Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21662078
154Insulin signaling pathway_Homo sapiens_hsa049100.21283993
155Fructose and mannose metabolism_Homo sapiens_hsa000510.20282439
156Linoleic acid metabolism_Homo sapiens_hsa005910.19656399
157Galactose metabolism_Homo sapiens_hsa000520.18245596
158Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14325044
159ECM-receptor interaction_Homo sapiens_hsa045120.14285136
160Amoebiasis_Homo sapiens_hsa051460.11303109
161Central carbon metabolism in cancer_Homo sapiens_hsa052300.08261436
162Protein digestion and absorption_Homo sapiens_hsa049740.08195051
163Longevity regulating pathway - mammal_Homo sapiens_hsa042110.01359351
164Renin-angiotensin system_Homo sapiens_hsa04614-0.1415335
165Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1253887
166Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1146012
167Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1139577
168Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0967051
169Type II diabetes mellitus_Homo sapiens_hsa04930-0.0861480
170African trypanosomiasis_Homo sapiens_hsa05143-0.0805795
171Focal adhesion_Homo sapiens_hsa04510-0.0706354
172Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0636278
173Malaria_Homo sapiens_hsa05144-0.0631736
174Pertussis_Homo sapiens_hsa05133-0.0552668
175Hepatitis C_Homo sapiens_hsa05160-0.0335560
176Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0329341
177Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0304714

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