ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to kinetochore (GO:0034501)	6.15948841
2	protein localization to chromosome, centromeric region (GO:0071459)	5.52461583
3	kinetochore organization (GO:0051383)	5.28591310
4	meiotic chromosome segregation (GO:0045132)	5.23467112
5	DNA unwinding involved in DNA replication (GO:0006268)	5.17241773
6	attachment of spindle microtubules to kinetochore (GO:0008608)	5.11113252
7	mitotic sister chromatid segregation (GO:0000070)	5.09614539
8	sister chromatid segregation (GO:0000819)	5.08515611
9	mitotic chromosome condensation (GO:0007076)	4.93312416
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.71699443
11	mitotic metaphase plate congression (GO:0007080)	4.60630234
12	CENP-A containing nucleosome assembly (GO:0034080)	4.53252361
13	metaphase plate congression (GO:0051310)	4.50831312
14	DNA strand elongation involved in DNA replication (GO:0006271)	4.47366146
15	mitotic sister chromatid cohesion (GO:0007064)	4.46318815
16	chromatin remodeling at centromere (GO:0031055)	4.45055857
17	kinetochore assembly (GO:0051382)	4.36927709
18	nuclear pore complex assembly (GO:0051292)	4.36138414
19	telomere maintenance via semi-conservative replication (GO:0032201)	4.35636068
20	nuclear pore organization (GO:0006999)	4.35575376
21	DNA replication initiation (GO:0006270)	4.35495630
22	mitotic recombination (GO:0006312)	4.33881297
23	DNA strand elongation (GO:0022616)	4.29625577
24	regulation of centriole replication (GO:0046599)	4.25622649
25	telomere maintenance via recombination (GO:0000722)	4.12389562
26	DNA replication-independent nucleosome organization (GO:0034724)	4.09251671
27	DNA replication-independent nucleosome assembly (GO:0006336)	4.09251671
28	regulation of DNA endoreduplication (GO:0032875)	4.09085679
29	DNA replication checkpoint (GO:0000076)	4.07023868
30	establishment of chromosome localization (GO:0051303)	4.04173885
31	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.97883187
32	protein localization to chromosome (GO:0034502)	3.93561398
33	DNA topological change (GO:0006265)	3.91834631
34	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.90662412
35	histone exchange (GO:0043486)	3.89536994
36	regulation of spindle organization (GO:0090224)	3.85834457
37	mitotic nuclear envelope disassembly (GO:0007077)	3.84420196
38	translesion synthesis (GO:0019985)	3.82980680
39	chromosome segregation (GO:0007059)	3.77533940
40	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.75022511
41	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.74587126
42	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.74587126
43	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.74587126
44	regulation of centrosome cycle (GO:0046605)	3.74459883
45	DNA geometric change (GO:0032392)	3.72621301
46	spindle checkpoint (GO:0031577)	3.70948154
47	DNA duplex unwinding (GO:0032508)	3.70844959
48	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.66317357
49	telomere maintenance via telomere lengthening (GO:0010833)	3.62539342
50	positive regulation of chromosome segregation (GO:0051984)	3.61150388
51	regulation of chromosome segregation (GO:0051983)	3.60184986
52	regulation of mitotic metaphase/anaphase transition (GO:0030071)	3.57831728
53	membrane disassembly (GO:0030397)	3.55962880
54	nuclear envelope disassembly (GO:0051081)	3.55962880
55	spindle assembly checkpoint (GO:0071173)	3.54759426
56	nucleotide-excision repair, DNA gap filling (GO:0006297)	3.51998875
57	chromosome condensation (GO:0030261)	3.50020675
58	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	3.48824448
59	chromatin assembly or disassembly (GO:0006333)	3.48622070
60	regulation of centrosome duplication (GO:0010824)	3.47060088
61	negative regulation of chromosome segregation (GO:0051985)	3.46987726
62	DNA replication-dependent nucleosome organization (GO:0034723)	3.46876837
63	DNA replication-dependent nucleosome assembly (GO:0006335)	3.46876837
64	regulation of sister chromatid cohesion (GO:0007063)	3.45864165
65	DNA conformation change (GO:0071103)	3.44924745
66	DNA synthesis involved in DNA repair (GO:0000731)	3.44166930
67	negative regulation of mitotic sister chromatid separation (GO:2000816)	3.43986538
68	negative regulation of mitotic sister chromatid segregation (GO:0033048)	3.43986538
69	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	3.43986538
70	negative regulation of sister chromatid segregation (GO:0033046)	3.43986538
71	establishment of integrated proviral latency (GO:0075713)	3.42583409
72	pore complex assembly (GO:0046931)	3.41309518
73	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.40626739
74	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.40626739
75	regulation of sister chromatid segregation (GO:0033045)	3.40193492
76	regulation of mitotic sister chromatid separation (GO:0010965)	3.40193492
77	regulation of mitotic sister chromatid segregation (GO:0033047)	3.40193492
78	protein K6-linked ubiquitination (GO:0085020)	3.36442955
79	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.35942378
80	double-strand break repair via nonhomologous end joining (GO:0006303)	3.35470647
81	non-recombinational repair (GO:0000726)	3.35470647
82	regulation of telomere maintenance via telomerase (GO:0032210)	3.35278354
83	DNA packaging (GO:0006323)	3.35197350
84	microtubule depolymerization (GO:0007019)	3.35153006
85	DNA strand renaturation (GO:0000733)	3.34185520
86	mitotic spindle assembly checkpoint (GO:0007094)	3.33311813
87	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	3.32737269
88	purine nucleobase biosynthetic process (GO:0009113)	3.26127950
89	mitotic spindle checkpoint (GO:0071174)	3.25153503
90	telomere maintenance (GO:0000723)	3.24956886
91	ATP-dependent chromatin remodeling (GO:0043044)	3.24072826
92	dosage compensation (GO:0007549)	3.23810060
93	replication fork processing (GO:0031297)	3.22788457
94	mismatch repair (GO:0006298)	3.20605582
95	regulation of mitotic spindle organization (GO:0060236)	3.20438976
96	telomere organization (GO:0032200)	3.20271776
97	regulation of histone H3-K9 methylation (GO:0051570)	3.19276067
98	heterochromatin organization (GO:0070828)	3.18201081
99	nucleobase biosynthetic process (GO:0046112)	3.18012594
100	synapsis (GO:0007129)	3.16475838
101	postreplication repair (GO:0006301)	3.12779297
102	microtubule polymerization or depolymerization (GO:0031109)	3.12715766
103	histone-serine phosphorylation (GO:0035404)	3.10483578
104	nuclear envelope organization (GO:0006998)	3.07342691
105	centriole replication (GO:0007099)	3.06426563
106	DNA ligation (GO:0006266)	3.04853422
107	chromosome organization (GO:0051276)	3.04404177
108	mitotic G2/M transition checkpoint (GO:0044818)	3.03923253
109	folic acid-containing compound biosynthetic process (GO:0009396)	3.00859270
110	DNA double-strand break processing (GO:0000729)	2.98336505
111	regulation of DNA-dependent DNA replication (GO:0090329)	2.94480648
112	intra-S DNA damage checkpoint (GO:0031573)	2.94306985
113	mitotic cell cycle (GO:0000278)	2.93565977
114	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.91925660

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXM1_23109430_ChIP-Seq_U2OS_Human	7.82458965
2	* E2F4_17652178_ChIP-ChIP_JURKAT_Human	5.35283979
3	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	4.57783701
4	AR_21909140_ChIP-Seq_LNCAP_Human	3.05568212
5	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.90453570
6	* E2F1_21310950_ChIP-Seq_MCF-7_Human	2.66827032
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.66029169
8	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.52736563
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41954839
10	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.39326144
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.27164801
12	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.23264251
13	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.19975977
14	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	2.16015369
15	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.02913609
16	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.02363366
17	E2F7_22180533_ChIP-Seq_HELA_Human	12.5995858
18	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.98123030
19	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.94149500
20	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.90054745
21	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.76273713
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.73440650
23	CIITA_25753668_ChIP-Seq_RAJI_Human	1.71338967
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.66865739
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.66487633
26	MYC_22102868_ChIP-Seq_BL_Human	1.61924453
27	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.57728943
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.53258717
29	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.52647597
30	* MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.51403852
31	XRN2_22483619_ChIP-Seq_HELA_Human	1.49931577
32	FOXP3_21729870_ChIP-Seq_TREG_Human	1.49692935
33	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.49544528
34	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.49173542
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48937885
36	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.41889973
37	* ELK1_19687146_ChIP-ChIP_HELA_Human	1.40499355
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.31436786
39	* TTF2_22483619_ChIP-Seq_HELA_Human	1.29292157
40	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.27707166
41	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.25363620
42	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.25348226
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.24987573
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.23397244
45	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.22625381
46	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	1.19566512
47	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.19111505
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19109816
49	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17881496
50	DCP1A_22483619_ChIP-Seq_HELA_Human	1.17475607
51	SCL_19346495_ChIP-Seq_HPC-7_Human	1.16607504
52	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.15495631
53	* NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.14027346
54	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.13811321
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.13649670
56	VDR_21846776_ChIP-Seq_THP-1_Human	1.11226512
57	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.10738703
58	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09500348
59	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.08934947
60	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.08024879
61	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.07323001
62	* KDM5A_27292631_Chip-Seq_BREAST_Human	1.06986198
63	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05181617
64	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.05005880
65	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.04149254
66	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.03177499
67	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.02227163
68	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.00398991
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.00082879
70	GABP_19822575_ChIP-Seq_HepG2_Human	0.99744899
71	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	0.95744629
72	* ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.95299996
73	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.94153723
74	SPI1_23547873_ChIP-Seq_NB4_Human	0.94148529
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.92976646
76	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.92558799
77	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.92351346
78	* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.92102035
79	* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.92058678
80	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.91504255
81	MYB_26560356_Chip-Seq_TH2_Human	0.90413726
82	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	0.87051552
83	MYB_21317192_ChIP-Seq_ERMYB_Mouse	0.86645744
84	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86572048
85	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.85493326
86	* SOX17_20123909_ChIP-Seq_XEN_Mouse	0.85404020
87	NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	0.84537553
88	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.84525685
89	* MYB_26560356_Chip-Seq_TH1_Human	0.82736346
90	IRF1_19129219_ChIP-ChIP_H3396_Human	0.81576939
91	TFEB_21752829_ChIP-Seq_HELA_Human	0.81070572
92	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.80884374
93	FUS_26573619_Chip-Seq_HEK293_Human	0.80134820
94	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.79714622
95	MYC_18940864_ChIP-ChIP_HL60_Human	0.79701976
96	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.78012275
97	* CHD1_26751641_Chip-Seq_LNCaP_Human	0.77351294
98	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.75078927
99	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.73372958
100	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.73227007
101	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.73015595
102	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.72263725
103	BRD4_27068464_Chip-Seq_AML-cells_Mouse	0.72017415
104	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.71747228
105	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.71639315
106	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.70766029
107	EWS_26573619_Chip-Seq_HEK293_Human	0.70270751
108	MAF_26560356_Chip-Seq_TH1_Human	0.70240158
109	* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.70231038
110	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.69630700
111	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.69079402
112	ZNF274_21170338_ChIP-Seq_K562_Hela	0.68447175
113	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.68426333
114	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.68248809
115	UTX_26944678_Chip-Seq_JUKART_Human	0.68203978
116	VDR_22108803_ChIP-Seq_LS180_Human	0.68140255
117	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.67587483
118	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.66723578
119	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.66255853
120	NANOG_21062744_ChIP-ChIP_HESCs_Human	0.65837857
121	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.62837547
122	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.62707711
123	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.60404388
124	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.60068292

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0010094_abnormal_chromosome_stability	4.90263970
2	MP0003693_abnormal_embryo_hatching	4.72380067
3	MP0003111_abnormal_nucleus_morphology	4.38604875
4	MP0008057_abnormal_DNA_replication	4.02239766
5	MP0003077_abnormal_cell_cycle	3.66147758
6	MP0004957_abnormal_blastocyst_morpholog	3.29388834
7	MP0008058_abnormal_DNA_repair	3.06191443
8	MP0008877_abnormal_DNA_methylation	3.02332369
9	MP0002396_abnormal_hematopoietic_system	2.66334990
10	MP0008007_abnormal_cellular_replicative	2.61114933
11	MP0003718_maternal_effect	2.58395972
12	MP0008932_abnormal_embryonic_tissue	2.37953083
13	MP0000566_synostosis	2.29503529
14	MP0010307_abnormal_tumor_latency	2.09434079
15	MP0004808_abnormal_hematopoietic_stem	2.07217319
16	MP0003787_abnormal_imprinting	1.99717823
17	MP0000350_abnormal_cell_proliferation	1.97285591
18	MP0002102_abnormal_ear_morphology	1.92494786
19	MP0003121_genomic_imprinting	1.88135149
20	MP0000569_abnormal_digit_pigmentation	1.76787058
21	MP0000490_abnormal_crypts_of	1.75524783
22	MP0001730_embryonic_growth_arrest	1.66976246
23	MP0010352_gastrointestinal_tract_polyps	1.56996048
24	MP0005076_abnormal_cell_differentiation	1.55542379
25	* MP0005380_embryogenesis_phenotype	1.47049748
26	* MP0001672_abnormal_embryogenesis/_devel	1.47049748
27	MP0003786_premature_aging	1.45098491
28	MP0009278_abnormal_bone_marrow	1.41404330
29	MP0001545_abnormal_hematopoietic_system	1.40767214
30	MP0005397_hematopoietic_system_phenotyp	1.40767214
31	MP0001697_abnormal_embryo_size	1.38302869
32	MP0003123_paternal_imprinting	1.36628962
33	MP0002210_abnormal_sex_determination	1.34903091
34	* MP0000313_abnormal_cell_death	1.33847046
35	MP0010030_abnormal_orbit_morphology	1.33226933
36	MP0004197_abnormal_fetal_growth/weight/	1.30164926
37	* MP0003984_embryonic_growth_retardation	1.29520432
38	MP0000703_abnormal_thymus_morphology	1.27886876
39	MP0002398_abnormal_bone_marrow	1.27300686
40	* MP0002085_abnormal_embryonic_tissue	1.26478271
41	MP0002019_abnormal_tumor_incidence	1.26025765
42	* MP0002088_abnormal_embryonic_growth/wei	1.25951721
43	MP0008995_early_reproductive_senescence	1.25438103
44	* MP0002080_prenatal_lethality	1.18968560
45	MP0001293_anophthalmia	1.18829786
46	MP0002086_abnormal_extraembryonic_tissu	1.17437335
47	* MP0002084_abnormal_developmental_patter	1.14095441
48	MP0000537_abnormal_urethra_morphology	1.13674136
49	MP0003763_abnormal_thymus_physiology	1.11258631
50	MP0006035_abnormal_mitochondrial_morpho	1.06737487
51	MP0002877_abnormal_melanocyte_morpholog	1.06010875
52	MP0001929_abnormal_gametogenesis	1.05509506
53	MP0000015_abnormal_ear_pigmentation	1.05149336
54	MP0002722_abnormal_immune_system	1.04501069
55	MP0000689_abnormal_spleen_morphology	1.04089365
56	MP0000358_abnormal_cell_content/	1.03504269
57	MP0003315_abnormal_perineum_morphology	1.03114764
58	MP0001145_abnormal_male_reproductive	1.02382251
59	MP0002009_preneoplasia	1.02036979
60	MP0003119_abnormal_digestive_system	0.97214429
61	MP0003890_abnormal_embryonic-extraembry	0.96086959
62	MP0009333_abnormal_splenocyte_physiolog	0.94978350
63	MP0001119_abnormal_female_reproductive	0.94807553
64	MP0004147_increased_porphyrin_level	0.94336814
65	MP0003937_abnormal_limbs/digits/tail_de	0.92547386
66	MP0000653_abnormal_sex_gland	0.91939490
67	MP0000733_abnormal_muscle_development	0.91330453
68	MP0002938_white_spotting	0.89016665
69	MP0009697_abnormal_copulation	0.88700165
70	MP0002429_abnormal_blood_cell	0.88607225
71	MP0000049_abnormal_middle_ear	0.87942181
72	MP0001800_abnormal_humoral_immune	0.87901862
73	MP0002095_abnormal_skin_pigmentation	0.86999499
74	MP0008789_abnormal_olfactory_epithelium	0.86942956
75	MP0001529_abnormal_vocalization	0.86498856
76	MP0001835_abnormal_antigen_presentation	0.86436809
77	MP0003567_abnormal_fetal_cardiomyocyte	0.84436626
78	MP0005187_abnormal_penis_morphology	0.83032319
79	MP0005174_abnormal_tail_pigmentation	0.82683463
80	MP0004233_abnormal_muscle_weight	0.81869119
81	MP0002452_abnormal_antigen_presenting	0.81667581
82	MP0000716_abnormal_immune_system	0.81656816
83	MP0003699_abnormal_female_reproductive	0.81532003
84	MP0003943_abnormal_hepatobiliary_system	0.80928656
85	MP0006054_spinal_hemorrhage	0.80655794
86	MP0002233_abnormal_nose_morphology	0.80052764
87	MP0003221_abnormal_cardiomyocyte_apopto	0.79706280
88	MP0001661_extended_life_span	0.79571090
89	MP0009703_decreased_birth_body	0.79189621
90	MP0002006_tumorigenesis	0.77512290
91	MP0002161_abnormal_fertility/fecundity	0.77230706
92	MP0005395_other_phenotype	0.75929561
93	MP0006292_abnormal_olfactory_placode	0.75160681
94	MP0009672_abnormal_birth_weight	0.74270392
95	MP0002111_abnormal_tail_morphology	0.74066383
96	MP0003950_abnormal_plasma_membrane	0.73671426
97	MP0002420_abnormal_adaptive_immunity	0.73443792
98	* MP0003861_abnormal_nervous_system	0.73374008
99	MP0001819_abnormal_immune_cell	0.73317000
100	MP0002697_abnormal_eye_size	0.72177674
101	MP0001286_abnormal_eye_development	0.71990415
102	MP0001727_abnormal_embryo_implantation	0.71954847
103	MP0005389_reproductive_system_phenotype	0.71459193
104	MP0006072_abnormal_retinal_apoptosis	0.71454605
105	MP0000432_abnormal_head_morphology	0.70922314
106	MP0000647_abnormal_sebaceous_gland	0.70676622
107	MP0004185_abnormal_adipocyte_glucose	0.70265864
108	MP0009053_abnormal_anal_canal	0.70215760
109	MP0000383_abnormal_hair_follicle	0.70112419
110	MP0002234_abnormal_pharynx_morphology	0.69723344
111	MP0002163_abnormal_gland_morphology	0.69391399
112	MP0005621_abnormal_cell_physiology	0.69288191
113	MP0003656_abnormal_erythrocyte_physiolo	0.68997565
114	MP0002092_abnormal_eye_morphology	0.68859057
115	MP0002166_altered_tumor_susceptibility	0.68474647
116	MP0003935_abnormal_craniofacial_develop	0.68161671
117	MP0005409_darkened_coat_color	0.68065909
118	MP0000428_abnormal_craniofacial_morphol	0.67955867
119	MP0002405_respiratory_system_inflammati	0.67924579
120	MP0003941_abnormal_skin_development	0.66265302
121	MP0005384_cellular_phenotype	0.65646441
122	MP0000427_abnormal_hair_cycle	0.65194776
123	MP0003755_abnormal_palate_morphology	0.65012235
124	MP0002075_abnormal_coat/hair_pigmentati	0.64814761
125	MP0003698_abnormal_male_reproductive	0.64303243
126	MP0003385_abnormal_body_wall	0.63490497
127	MP0002160_abnormal_reproductive_system	0.62568361
128	MP0002932_abnormal_joint_morphology	0.62197767
129	MP0003115_abnormal_respiratory_system	0.61877465
130	MP0001853_heart_inflammation	0.61780813
131	MP0005501_abnormal_skin_physiology	0.60429145
132	MP0002723_abnormal_immune_serum	0.59962275
133	MP0001346_abnormal_lacrimal_gland	0.59785601
134	MP0001919_abnormal_reproductive_system	0.57326213
135	MP0008770_decreased_survivor_rate	0.54400477
136	MP0003942_abnormal_urinary_system	0.54244322

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chromsome breakage (HP:0040012)	5.20950011
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	5.15747538
3	Abnormality of chromosome stability (HP:0003220)	3.73259583
4	Ectopic kidney (HP:0000086)	3.54710966
5	Birth length less than 3rd percentile (HP:0003561)	3.38231931
6	Increased nuchal translucency (HP:0010880)	3.33320538
7	Impulsivity (HP:0100710)	3.20607406
8	Abnormality of the preputium (HP:0100587)	3.18457587
9	Meckel diverticulum (HP:0002245)	3.17677828
10	Selective tooth agenesis (HP:0001592)	3.17597798
11	Volvulus (HP:0002580)	3.14089768
12	Cortical dysplasia (HP:0002539)	3.02931909
13	Abnormality of the ileum (HP:0001549)	3.02412011
14	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.00047031
15	Abnormal number of incisors (HP:0011064)	2.86064023
16	Short 4th metacarpal (HP:0010044)	2.84257104
17	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.84257104
18	Small intestinal stenosis (HP:0012848)	2.74676657
19	Duodenal stenosis (HP:0100867)	2.74676657
20	Patellar aplasia (HP:0006443)	2.71321921
21	Myelodysplasia (HP:0002863)	2.70497502
22	Abnormality of the carotid arteries (HP:0005344)	2.68358305
23	Abnormal lung lobation (HP:0002101)	2.65597483
24	High pitched voice (HP:0001620)	2.61291620
25	Nephroblastoma (Wilms tumor) (HP:0002667)	2.60769316
26	Reticulocytopenia (HP:0001896)	2.54773732
27	Aplasia/Hypoplasia of the patella (HP:0006498)	2.50198151
28	Embryonal renal neoplasm (HP:0011794)	2.49518232
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.43455569
30	Sloping forehead (HP:0000340)	2.42115444
31	Abnormality of the fingertips (HP:0001211)	2.38801713
32	Abnormality of chromosome segregation (HP:0002916)	2.35245730
33	Ependymoma (HP:0002888)	2.29177167
34	Duplicated collecting system (HP:0000081)	2.28388418
35	Prominent nose (HP:0000448)	2.26516420
36	Deep philtrum (HP:0002002)	2.25358168
37	Choanal atresia (HP:0000453)	2.23891658
38	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.23768284
39	Clubbing of toes (HP:0100760)	2.21739363
40	Abnormality of the anterior horn cell (HP:0006802)	2.21302921
41	Degeneration of anterior horn cells (HP:0002398)	2.21302921
42	Arteriovenous malformation (HP:0100026)	2.18440256
43	Bone marrow hypocellularity (HP:0005528)	2.16957382
44	Proximal placement of thumb (HP:0009623)	2.16593548
45	Panhypogammaglobulinemia (HP:0003139)	2.15801644
46	Medulloblastoma (HP:0002885)	2.15744420
47	Absent radius (HP:0003974)	2.15415588
48	Abnormality of the duodenum (HP:0002246)	2.15076397
49	Recurrent viral infections (HP:0004429)	2.14513818
50	Abnormality of cochlea (HP:0000375)	2.14489240
51	Oral leukoplakia (HP:0002745)	2.13835197
52	Glioma (HP:0009733)	2.13385789
53	Deviation of the thumb (HP:0009603)	2.13346918
54	Acute myeloid leukemia (HP:0004808)	2.12325029
55	Abnormality of the renal collecting system (HP:0004742)	2.09293224
56	Abnormality of the labia minora (HP:0012880)	2.09055548
57	Hypoplastic pelvis (HP:0008839)	2.05435106
58	Atresia of the external auditory canal (HP:0000413)	2.05331992
59	Hypoplasia of the pons (HP:0012110)	2.03970599
60	Abnormality of DNA repair (HP:0003254)	2.02254579
61	Tracheoesophageal fistula (HP:0002575)	2.01893379
62	Renal duplication (HP:0000075)	2.01758933
63	Squamous cell carcinoma (HP:0002860)	2.00342563
64	Neoplasm of the colon (HP:0100273)	1.99155688
65	Abnormality of the pons (HP:0007361)	1.98754484
66	Rhabdomyosarcoma (HP:0002859)	1.98205497
67	Breast hypoplasia (HP:0003187)	1.97168476
68	Aplasia involving forearm bones (HP:0009822)	1.96973085
69	Absent forearm bone (HP:0003953)	1.96973085
70	Pelvic girdle muscle weakness (HP:0003749)	1.96500744
71	Mesomelia (HP:0003027)	1.94544943
72	Abnormality of the incisor (HP:0000676)	1.93555699
73	Cafe-au-lait spot (HP:0000957)	1.92921219
74	Trigonocephaly (HP:0000243)	1.91589203
75	Embryonal neoplasm (HP:0002898)	1.90289409
76	Renovascular hypertension (HP:0100817)	1.90060413
77	Short thumb (HP:0009778)	1.89598904
78	Hyperacusis (HP:0010780)	1.87885543
79	Overlapping toe (HP:0001845)	1.87633928
80	Astrocytoma (HP:0009592)	1.87526707
81	Abnormality of the astrocytes (HP:0100707)	1.87526707
82	Poikiloderma (HP:0001029)	1.86869778
83	Syringomyelia (HP:0003396)	1.86141423
84	Spinal cord lesions (HP:0100561)	1.86141423
85	Absent thumb (HP:0009777)	1.84894332
86	Abnormality of the 4th metacarpal (HP:0010012)	1.84322359
87	Lymphoma (HP:0002665)	1.84249233
88	Long eyelashes (HP:0000527)	1.81704823
89	Elfin facies (HP:0004428)	1.80375678
90	Overriding aorta (HP:0002623)	1.77974696
91	IgM deficiency (HP:0002850)	1.77949035
92	Abnormality of homocysteine metabolism (HP:0010919)	1.76751725
93	Homocystinuria (HP:0002156)	1.76751725
94	Abnormal umbilical cord blood vessels (HP:0011403)	1.76361271
95	Single umbilical artery (HP:0001195)	1.76361271
96	Abnormality of the fetal cardiovascular system (HP:0010948)	1.76361271
97	Triphalangeal thumb (HP:0001199)	1.76349860
98	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.76123738
99	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.76010415
100	Duplication of thumb phalanx (HP:0009942)	1.75720771
101	Ureteral duplication (HP:0000073)	1.75681804
102	Small hand (HP:0200055)	1.74731588
103	Premature graying of hair (HP:0002216)	1.73927615
104	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.72382661
105	Short middle phalanx of the 5th finger (HP:0004220)	1.72182459
106	Sandal gap (HP:0001852)	1.71625754
107	Abnormality of T cell physiology (HP:0011840)	1.71602434
108	Agnosia (HP:0010524)	1.70945020
109	Abnormality of the musculature of the pelvis (HP:0001469)	1.70397740
110	Abnormality of the hip-girdle musculature (HP:0001445)	1.70397740
111	Ovarian neoplasm (HP:0100615)	1.69917841
112	Recurrent fungal infections (HP:0002841)	1.65953043
113	Heterotopia (HP:0002282)	1.65437094
114	11 pairs of ribs (HP:0000878)	1.65258408
115	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.64977090
116	Missing ribs (HP:0000921)	1.64678681
117	Obsessive-compulsive behavior (HP:0000722)	1.64633307
118	Horseshoe kidney (HP:0000085)	1.62402585
119	Multiple enchondromatosis (HP:0005701)	1.62338602
120	Colon cancer (HP:0003003)	1.62260491
121	Irregular epiphyses (HP:0010582)	1.59777372
122	Microtia (HP:0008551)	1.59368241
123	Abnormality of the columella (HP:0009929)	1.59129110
124	Carpal bone hypoplasia (HP:0001498)	1.59114270
125	Neoplasm of striated muscle (HP:0009728)	1.58278511
126	Broad palm (HP:0001169)	1.58260489
127	Flared metaphyses (HP:0003015)	1.57948436
128	Aplasia/Hypoplasia of the thymus (HP:0010515)	1.57383469
129	Facial hemangioma (HP:0000329)	1.57367595
130	Cleft eyelid (HP:0000625)	1.57343669
131	Neoplasm of the pancreas (HP:0002894)	1.56718406
132	Abnormality of methionine metabolism (HP:0010901)	1.55557032
133	Morphological abnormality of the inner ear (HP:0011390)	1.52696927
134	High anterior hairline (HP:0009890)	1.51288109
135	Megaloblastic anemia (HP:0001889)	1.49036312
136	Oligohydramnios (HP:0001562)	1.49008597
137	Renal agenesis (HP:0000104)	1.44800346
138	Abnormality of the umbilical cord (HP:0010881)	1.44737969
139	Facial cleft (HP:0002006)	1.44502942

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	5.01743248
2	NEK2	3.77450782
3	BUB1	3.62539065
4	WEE1	3.47758246
5	TTK	3.04847201
6	ACVR1B	3.04497610
7	PBK	2.73952160
8	CDK12	2.70612516
9	PLK4	2.53451337
10	SRPK1	2.45195820
11	STK4	2.28335558
12	BRSK2	2.26607531
13	ATR	2.16831337
14	PLK1	2.10151788
15	MKNK1	1.99583161
16	RPS6KA4	1.97994048
17	AURKB	1.97864830
18	CCNB1	1.74244315
19	CHEK2	1.73283433
20	BRD4	1.70284022
21	ERBB3	1.68345761
22	EIF2AK1	1.65034662
23	PLK3	1.58716073
24	ZAK	1.58224032
25	BRSK1	1.52815953
26	MKNK2	1.51512278
27	CDK4	1.51080082
28	TLK1	1.48002473
29	CDK7	1.47749127
30	NEK1	1.44893315
31	CHEK1	1.42833398
32	PNCK	1.38762545
33	STK10	1.35869245
34	DYRK3	1.27116983
35	CDK6	1.26727181
36	NEK9	1.26392535
37	ATM	1.25515053
38	NUAK1	1.23970662
39	VRK1	1.22083666
40	PASK	1.21189232
41	MELK	1.21160355
42	MAP3K10	1.20635610
43	PIM1	1.19717853
44	EEF2K	1.19544229
45	STK3	1.18470587
46	EIF2AK2	1.15617431
47	TAF1	1.10728875
48	LATS1	1.09062569
49	CLK1	1.08606558
50	MAP3K8	1.06745915
51	TGFBR1	1.06739582
52	IRAK4	0.96838727
53	TRIM28	0.95450725
54	BRAF	0.93166856
55	VRK2	0.90832444
56	MAP4K1	0.88676011
57	SCYL2	0.88430864
58	CDK2	0.87554558
59	YES1	0.86050687
60	CDK1	0.85298595
61	RPS6KB2	0.85215968
62	AURKA	0.83594538
63	BMPR1B	0.76604910
64	ERBB4	0.74640714
65	MST1R	0.74101131
66	CDK9	0.70409983
67	RPS6KA5	0.67461270
68	JAK3	0.66683131
69	TXK	0.65050293
70	IRAK3	0.64639536
71	NME1	0.63461529
72	PLK2	0.63358080
73	TNIK	0.62346316
74	MET	0.61483190
75	STK38L	0.59872133
76	TESK2	0.59737929
77	CHUK	0.58127350
78	BTK	0.55263770
79	EIF2AK3	0.50543962
80	PAK4	0.50464045
81	KIT	0.49945657
82	TSSK6	0.49718699
83	SIK2	0.46898791
84	SMG1	0.45581867
85	CAMK1G	0.45372859
86	NME2	0.44927420
87	MST4	0.44697547
88	WNK4	0.44678160
89	AKT1	0.44404251
90	MAPK14	0.43507561
91	ALK	0.42111223
92	CSNK2A1	0.41332114
93	BMPR2	0.40968415
94	CAMK1D	0.40494884
95	CDK8	0.39161384
96	ICK	0.39033358
97	BCR	0.38776801
98	TEC	0.36603896
99	RAF1	0.36365807
100	PRKDC	0.36112427
101	CSNK2A2	0.36054643
102	MAP3K4	0.35847140
103	IKBKE	0.35707754
104	CSF1R	0.35306331
105	TRPM7	0.35132396
106	STK16	0.35071387
107	PRKCI	0.33997332
108	TESK1	0.33953388
109	TAOK2	0.33683842
110	CSNK1E	0.33182695
111	CSNK1D	0.30875333
112	MAP3K14	0.30255227
113	MTOR	0.30103603
114	AKT2	0.29987588
115	RPS6KA6	0.29673550
116	FLT3	0.29087662
117	FGFR3	0.27560252
118	MARK3	0.27149147
119	GSK3B	0.26198252
120	CDK3	0.26189038
121	IKBKB	0.25742061
122	MAPK1	0.25339769
123	FGFR1	0.25132323
124	TTN	0.24843993
125	PAK1	0.24681750
126	PDK2	0.23911046
127	DYRK1B	0.23774873
128	RPS6KB1	0.23200874
129	CDK18	0.22814280
130	STK39	0.22131281
131	LATS2	0.21696119
132	CDK15	0.20861040

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	DNA replication_Homo sapiens_hsa03030	5.07094759
2	Mismatch repair_Homo sapiens_hsa03430	4.08883147
3	Homologous recombination_Homo sapiens_hsa03440	3.68037437
4	Base excision repair_Homo sapiens_hsa03410	3.51337510
5	Cell cycle_Homo sapiens_hsa04110	3.39937051
6	Fanconi anemia pathway_Homo sapiens_hsa03460	3.19769374
7	Spliceosome_Homo sapiens_hsa03040	2.65335371
8	Nucleotide excision repair_Homo sapiens_hsa03420	2.61736832
9	One carbon pool by folate_Homo sapiens_hsa00670	2.47927760
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.44450560
11	RNA transport_Homo sapiens_hsa03013	2.43306945
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.39785759
13	p53 signaling pathway_Homo sapiens_hsa04115	2.01251958
14	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.89761099
15	mRNA surveillance pathway_Homo sapiens_hsa03015	1.88588558
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.70301845
17	Basal transcription factors_Homo sapiens_hsa03022	1.64979609
18	RNA degradation_Homo sapiens_hsa03018	1.60127555
19	Herpes simplex infection_Homo sapiens_hsa05168	1.52210340
20	RNA polymerase_Homo sapiens_hsa03020	1.47862786
21	Viral carcinogenesis_Homo sapiens_hsa05203	1.46341202
22	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.45640343
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.39807751
24	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.35456895
25	Primary immunodeficiency_Homo sapiens_hsa05340	1.30777142
26	Small cell lung cancer_Homo sapiens_hsa05222	1.27099575
27	MicroRNAs in cancer_Homo sapiens_hsa05206	1.21703222
28	Epstein-Barr virus infection_Homo sapiens_hsa05169	1.19778471
29	HTLV-I infection_Homo sapiens_hsa05166	1.19213151
30	Protein export_Homo sapiens_hsa03060	1.14723812
31	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.13351392
32	Steroid biosynthesis_Homo sapiens_hsa00100	1.11419964
33	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.11410763
34	Oocyte meiosis_Homo sapiens_hsa04114	1.11152756
35	Ribosome_Homo sapiens_hsa03010	1.08723133
36	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.08604120
37	Proteasome_Homo sapiens_hsa03050	1.08298330
38	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.08210035
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.06552659
40	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	1.05019282
41	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.03113812
42	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.02767155
43	Antigen processing and presentation_Homo sapiens_hsa04612	1.00565923
44	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99081732
45	Measles_Homo sapiens_hsa05162	0.95161557
46	Hepatitis B_Homo sapiens_hsa05161	0.94205590
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.90280802
48	Apoptosis_Homo sapiens_hsa04210	0.88964068
49	Purine metabolism_Homo sapiens_hsa00230	0.88635164
50	Propanoate metabolism_Homo sapiens_hsa00640	0.85782378
51	Alcoholism_Homo sapiens_hsa05034	0.85615215
52	Folate biosynthesis_Homo sapiens_hsa00790	0.82959466
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.77303881
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.77271629
55	Pancreatic cancer_Homo sapiens_hsa05212	0.76560543
56	Notch signaling pathway_Homo sapiens_hsa04330	0.76082495
57	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.75200875
58	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.75065425
59	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.75038775
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75034344
61	Prostate cancer_Homo sapiens_hsa05215	0.74324633
62	Carbon metabolism_Homo sapiens_hsa01200	0.73073671
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70850104
64	Viral myocarditis_Homo sapiens_hsa05416	0.70697089
65	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.70686765
66	Leishmaniasis_Homo sapiens_hsa05140	0.70321766
67	Legionellosis_Homo sapiens_hsa05134	0.68489846
68	Lysine degradation_Homo sapiens_hsa00310	0.67060355
69	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.67018121
70	Colorectal cancer_Homo sapiens_hsa05210	0.65783748
71	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.65170290
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63574286
73	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62258741
74	Shigellosis_Homo sapiens_hsa05131	0.61742415
75	Influenza A_Homo sapiens_hsa05164	0.61500995
76	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61343986
77	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60746614
78	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60714143
79	Non-small cell lung cancer_Homo sapiens_hsa05223	0.58223416
80	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.54602583
81	Selenocompound metabolism_Homo sapiens_hsa00450	0.50806826
82	Huntingtons disease_Homo sapiens_hsa05016	0.50422382
83	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.50162122
84	Pathways in cancer_Homo sapiens_hsa05200	0.50048838
85	FoxO signaling pathway_Homo sapiens_hsa04068	0.49359377
86	Glutathione metabolism_Homo sapiens_hsa00480	0.48498537
87	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.48367500
88	Bladder cancer_Homo sapiens_hsa05219	0.48257051
89	Toxoplasmosis_Homo sapiens_hsa05145	0.47797635
90	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.47711489
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.47330839
92	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.46033944
93	Adherens junction_Homo sapiens_hsa04520	0.45334131
94	Fatty acid elongation_Homo sapiens_hsa00062	0.45265876
95	Basal cell carcinoma_Homo sapiens_hsa05217	0.44974912
96	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44745210
97	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43999780
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43939011
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.43201291
100	Thyroid cancer_Homo sapiens_hsa05216	0.42543053
101	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.39651615
102	TNF signaling pathway_Homo sapiens_hsa04668	0.38879501
103	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.38352343
104	Hippo signaling pathway_Homo sapiens_hsa04390	0.37716139
105	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.37559310
106	Tuberculosis_Homo sapiens_hsa05152	0.36629132
107	Acute myeloid leukemia_Homo sapiens_hsa05221	0.35535725
108	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.35495103
109	Melanoma_Homo sapiens_hsa05218	0.35224700
110	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.35073595
111	Metabolic pathways_Homo sapiens_hsa01100	0.34458661
112	Osteoclast differentiation_Homo sapiens_hsa04380	0.33471608
113	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33221885
114	Pentose phosphate pathway_Homo sapiens_hsa00030	0.32984125
115	Proteoglycans in cancer_Homo sapiens_hsa05205	0.32297847
116	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.32091229
117	Malaria_Homo sapiens_hsa05144	0.31942414
118	Fatty acid metabolism_Homo sapiens_hsa01212	0.30850766
119	Butanoate metabolism_Homo sapiens_hsa00650	0.30330693
120	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.30159166
121	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.30148427
122	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.29141620
123	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.28099855
124	Endometrial cancer_Homo sapiens_hsa05213	0.27683207
125	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27131951
126	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.26634661
127	Parkinsons disease_Homo sapiens_hsa05012	0.26012229
128	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.25126186
129	Allograft rejection_Homo sapiens_hsa05330	0.24857571
130	Platelet activation_Homo sapiens_hsa04611	0.24696125
131	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.24624011
132	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.24101435
133	Wnt signaling pathway_Homo sapiens_hsa04310	0.23960831
134	Chemokine signaling pathway_Homo sapiens_hsa04062	0.23859272
135	Glioma_Homo sapiens_hsa05214	0.23166875
136	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.22881648
137	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.22400058
138	Olfactory transduction_Homo sapiens_hsa04740	0.21809081
139	Sulfur relay system_Homo sapiens_hsa04122	0.17910344
140	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.14390040
141	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.14131498
142	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.13699908
143	Nitrogen metabolism_Homo sapiens_hsa00910	0.11146076
144	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.09016772

STIL

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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