STIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.64965908
2antigen processing and presentation of endogenous antigen (GO:0019883)4.20280632
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.09257120
4creatine metabolic process (GO:0006600)3.60471278
5negative thymic T cell selection (GO:0045060)3.54383479
6negative regulation of inclusion body assembly (GO:0090084)3.46944883
7central nervous system myelination (GO:0022010)3.41703786
8axon ensheathment in central nervous system (GO:0032291)3.41703786
9regulation of B cell receptor signaling pathway (GO:0050855)3.41274259
10negative T cell selection (GO:0043383)3.40323262
11germinal center formation (GO:0002467)3.33856874
12detection of bacterium (GO:0016045)3.32604142
13detection of other organism (GO:0098543)3.30879522
14B cell receptor signaling pathway (GO:0050853)3.29874794
15response to muramyl dipeptide (GO:0032495)3.24199427
16neutrophil activation involved in immune response (GO:0002283)3.18568036
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.15103683
18sarcoplasmic reticulum calcium ion transport (GO:0070296)3.11253237
19positive regulation of B cell differentiation (GO:0045579)3.09289900
20neuronal action potential propagation (GO:0019227)3.05036077
21leukocyte aggregation (GO:0070486)2.98423388
22positive regulation by symbiont of host defense response (GO:0052509)2.97908875
23modulation by symbiont of host defense response (GO:0052031)2.97908875
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97908875
25modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97908875
26positive regulation by organism of defense response of other organism involved in symbiotic interact2.97908875
27modulation by symbiont of host immune response (GO:0052553)2.97908875
28skeletal muscle contraction (GO:0003009)2.95245802
29response to peptidoglycan (GO:0032494)2.87237055
30peptidyl-tyrosine autophosphorylation (GO:0038083)2.86895249
31macrophage activation involved in immune response (GO:0002281)2.86174483
32cellular extravasation (GO:0045123)2.84805822
33negative regulation of lymphocyte mediated immunity (GO:0002707)2.83451993
34negative regulation of cell killing (GO:0031342)2.81587048
35negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81587048
36mannose metabolic process (GO:0006013)2.76939001
37ensheathment of neurons (GO:0007272)2.76583389
38axon ensheathment (GO:0008366)2.76583389
39myelination (GO:0042552)2.75687717
40fatty acid elongation (GO:0030497)2.74633841
41potassium ion import (GO:0010107)2.74192114
42detection of external biotic stimulus (GO:0098581)2.74015976
43positive regulation of granulocyte differentiation (GO:0030854)2.73790790
44negative regulation of leukocyte mediated immunity (GO:0002704)2.69688771
45positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68563863
46regulation of necroptotic process (GO:0060544)2.65565308
47regulation of ARF protein signal transduction (GO:0032012)2.63865601
48negative regulation of T cell mediated immunity (GO:0002710)2.62905129
49T cell migration (GO:0072678)2.61274958
50activated T cell proliferation (GO:0050798)2.60251350
51regulation of skeletal muscle contraction (GO:0014819)2.59956160
52protein targeting to Golgi (GO:0000042)2.59770822
53signal complex assembly (GO:0007172)2.59288260
54regulation of leukocyte degranulation (GO:0043300)2.59269138
55regulation of B cell differentiation (GO:0045577)2.58241364
56establishment of protein localization to Golgi (GO:0072600)2.55688147
57cellular potassium ion homeostasis (GO:0030007)2.55439232
58Peyers patch development (GO:0048541)2.54894299
59mucosal-associated lymphoid tissue development (GO:0048537)2.54894299
60regulation of mast cell degranulation (GO:0043304)2.53712806
61response to methylmercury (GO:0051597)2.52482008
62regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50664391
63skeletal muscle adaptation (GO:0043501)2.47563381
64Golgi to endosome transport (GO:0006895)2.45185474
65myelin maintenance (GO:0043217)2.44615950
66angiogenesis involved in wound healing (GO:0060055)2.44275116
67regulation of T-helper 2 cell differentiation (GO:0045628)2.41796888
68negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.40142267
69response to laminar fluid shear stress (GO:0034616)2.39824400
70nerve growth factor signaling pathway (GO:0038180)2.38794858
71regulation of platelet aggregation (GO:0090330)2.37992561
72tolerance induction (GO:0002507)2.37813578
73positive regulation of gamma-delta T cell activation (GO:0046645)2.37695970
74JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36401573
75type I interferon signaling pathway (GO:0060337)2.36125217
76cellular response to type I interferon (GO:0071357)2.36125217
77response to type I interferon (GO:0034340)2.35756039
78lipid translocation (GO:0034204)2.35359607
79phospholipid translocation (GO:0045332)2.35359607
80skeletal muscle fiber development (GO:0048741)2.35214384
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.35115449
82detection of biotic stimulus (GO:0009595)2.35034762
83response to lipoprotein particle (GO:0055094)2.34626557
84muscle filament sliding (GO:0030049)2.34479607
85actin-myosin filament sliding (GO:0033275)2.34479607
86sodium ion export (GO:0071436)2.34234281
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.34042977
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.34042977
89B cell homeostasis (GO:0001782)2.33924912
90retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31790001
91negative regulation of necroptotic process (GO:0060546)2.31116208
92positive regulation of receptor recycling (GO:0001921)2.30823453
93megakaryocyte development (GO:0035855)2.30227536
94detection of molecule of bacterial origin (GO:0032490)2.29218228
95desmosome organization (GO:0002934)2.28770026
96regulation of gamma-delta T cell differentiation (GO:0045586)2.28005072
97myeloid cell activation involved in immune response (GO:0002275)2.27210882
98immunoglobulin mediated immune response (GO:0016064)2.27033669
99antigen processing and presentation via MHC class Ib (GO:0002475)2.26475650
100regulation of beta-amyloid formation (GO:1902003)2.26256845
101positive T cell selection (GO:0043368)2.25838990
102negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.25652781
103negative regulation of T-helper cell differentiation (GO:0045623)2.25652781
104negative regulation of innate immune response (GO:0045824)2.25559358
105regulation of mast cell activation involved in immune response (GO:0033006)2.25250278
106response to host (GO:0075136)2.25222286
107response to host defenses (GO:0052200)2.25222286
108response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25222286
109regulation of extracellular matrix disassembly (GO:0010715)2.24573068
110stress fiber assembly (GO:0043149)2.24322015
111protein localization to endosome (GO:0036010)2.22807355
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.22740985
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.22239583
114regulation of granulocyte differentiation (GO:0030852)2.22129599
115pinocytosis (GO:0006907)2.20664133
116positive thymic T cell selection (GO:0045059)2.20604953
117negative regulation of glycoprotein biosynthetic process (GO:0010561)2.20243736
118response to host immune response (GO:0052572)2.20211833
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.20211833
120cellular response to interleukin-15 (GO:0071350)2.18741685
121carnitine transmembrane transport (GO:1902603)2.18501931
122hypotonic response (GO:0006971)2.18248940
123NIK/NF-kappaB signaling (GO:0038061)2.18060970
124endoplasmic reticulum organization (GO:0007029)2.18025792
125regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.17902492
126glycine transport (GO:0015816)2.17753513
127negative regulation of toll-like receptor signaling pathway (GO:0034122)2.16592744
128regulation of collateral sprouting (GO:0048670)2.16581157
129synaptic vesicle maturation (GO:0016188)2.15954186
130regulation of T cell tolerance induction (GO:0002664)2.15749765
131negative regulation of acute inflammatory response (GO:0002674)2.15697224
132regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.15499512
133regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.14954787
134regulation of natural killer cell mediated immunity (GO:0002715)2.14954787
135long-chain fatty acid biosynthetic process (GO:0042759)2.14849542
136positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.14600286
137lymphocyte homeostasis (GO:0002260)2.14447888
138neutrophil activation (GO:0042119)2.14195384
139activation of protein kinase A activity (GO:0034199)2.13765700
140regulation of skeletal muscle cell differentiation (GO:2001014)2.12166174
141locomotory exploration behavior (GO:0035641)2.11934982
142positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.11887947
143import into cell (GO:0098657)2.10972540
144positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.10457841
145negative regulation of neurotransmitter secretion (GO:0046929)2.09468394
146long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.08550993
147thymic T cell selection (GO:0045061)2.08402479
148cilium or flagellum-dependent cell motility (GO:0001539)2.08296016
149regulation of ARF GTPase activity (GO:0032312)2.06058779
150carnitine shuttle (GO:0006853)2.05967386
151gamma-aminobutyric acid transport (GO:0015812)2.05132654
152neuromuscular junction development (GO:0007528)2.04889854
153mating behavior (GO:0007617)2.02462261
154potassium ion homeostasis (GO:0055075)2.02010668
155fusion of sperm to egg plasma membrane (GO:0007342)2.01945164
156T cell selection (GO:0045058)2.01139277
157negative regulation of neurotransmitter transport (GO:0051589)2.00307754
158plasma membrane repair (GO:0001778)2.00282915
159regulation of amyloid precursor protein catabolic process (GO:1902991)2.00128421
160myotube cell development (GO:0014904)1.99600207
161negative regulation of macroautophagy (GO:0016242)1.99262769
162membrane tubulation (GO:0097320)1.98162721
163L-amino acid import (GO:0043092)1.97101395
164regulation of cytokine production involved in inflammatory response (GO:1900015)1.96408799
165regulation of gamma-delta T cell activation (GO:0046643)1.95759865
166amyloid precursor protein metabolic process (GO:0042982)1.95758292
167regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.95293394
168amino-acid betaine transport (GO:0015838)1.93942145
169carnitine transport (GO:0015879)1.93942145
170long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)1.93852766
171fatty-acyl-CoA metabolic process (GO:0035337)1.92713504
172response to interleukin-15 (GO:0070672)1.92661476
173vesicle targeting (GO:0006903)1.92239596
174regulation of short-term neuronal synaptic plasticity (GO:0048172)1.90675720
175positive regulation of calcium ion-dependent exocytosis (GO:0045956)1.90341036
176cellular response to epinephrine stimulus (GO:0071872)1.89589693
177calcium ion import (GO:0070509)1.88451023
178actin-mediated cell contraction (GO:0070252)1.87240251
179regulation of lipoprotein metabolic process (GO:0050746)1.86807514
180membrane depolarization during cardiac muscle cell action potential (GO:0086012)1.86337339
181response to epinephrine (GO:0071871)1.85494517
182positive regulation of Rap GTPase activity (GO:0032854)1.84842850
183membrane depolarization during action potential (GO:0086010)1.83662289
184regulation of cell communication by electrical coupling (GO:0010649)1.82853728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.52482384
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.55042621
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49892738
4MYC_22102868_ChIP-Seq_BL_Human2.49657621
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.43967787
6VDR_21846776_ChIP-Seq_THP-1_Human2.41273340
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23696283
8* TCF7_22412390_ChIP-Seq_EML_Mouse2.21584340
9EZH2_22144423_ChIP-Seq_EOC_Human2.20528281
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16110743
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12960866
12VDR_24763502_ChIP-Seq_THP-1_Human2.08664367
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08346427
14SCL_19346495_ChIP-Seq_HPC-7_Human2.06728285
15DROSHA_22980978_ChIP-Seq_HELA_Human2.06617140
16LXR_22292898_ChIP-Seq_THP-1_Human2.04226796
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03601528
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.02834553
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01487167
20E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01185725
21* MAF_26560356_Chip-Seq_TH1_Human2.00404752
22* ELK3_25401928_ChIP-Seq_HUVEC_Human1.99680119
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97790981
24SPI1_23127762_ChIP-Seq_K562_Human1.96135066
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.90458789
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88422363
27* RUNX1_22412390_ChIP-Seq_EML_Mouse1.82850451
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80644422
29GATA1_19941827_ChIP-Seq_MEL_Mouse1.80544935
30IRF8_27001747_Chip-Seq_BMDM_Mouse1.79196588
31UTX_26944678_Chip-Seq_JUKART_Human1.76032271
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.74307757
33SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70872418
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.70708046
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.67921504
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.65448917
37RUNX_20019798_ChIP-Seq_JUKART_Human1.64401882
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63298956
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.56875446
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.54215745
41MYB_26560356_Chip-Seq_TH2_Human1.53871469
42RARB_27405468_Chip-Seq_BRAIN_Mouse1.51134948
43MAF_26560356_Chip-Seq_TH2_Human1.49593902
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49501455
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47799573
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.46998654
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.46895126
48* RXR_22158963_ChIP-Seq_LIVER_Mouse1.46300607
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45917019
50TP63_17297297_ChIP-ChIP_HaCaT_Human1.45884324
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44440656
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.44419809
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.44419809
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.43231278
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.43015250
56MYB_26560356_Chip-Seq_TH1_Human1.42782409
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.42528917
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41091160
59LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40843628
60* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.40808375
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40666089
62ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40061100
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39851843
64RACK7_27058665_Chip-Seq_MCF-7_Human1.36446356
65AR_21572438_ChIP-Seq_LNCaP_Human1.35303809
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35099278
67* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.34401487
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33610266
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33598530
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.33013140
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.29416730
72* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27210676
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.24930985
74* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24119095
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.23664457
76SPI1_23547873_ChIP-Seq_NB4_Human1.23327990
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22609319
78GATA1_22025678_ChIP-Seq_K562_Human1.20725915
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20470366
80GBX2_23144817_ChIP-Seq_PC3_Human1.17462535
81GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16633829
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15845324
83* NCOR1_26117541_ChIP-Seq_K562_Human1.15732490
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15672246
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14942983
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.14908776
87TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14475317
88ESR1_20079471_ChIP-ChIP_T-47D_Human1.14438666
89* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13530784
90KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12505743
91RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12169083
92* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.12006609
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11522768
94* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10398230
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.09912752
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09537339
97* GATA1_19941826_ChIP-Seq_K562_Human1.09426807
98BP1_19119308_ChIP-ChIP_Hs578T_Human1.08122090
99* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07874889
100NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07391478
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06996602
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06717907
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06586962
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06340420
105ELF1_20517297_ChIP-Seq_JURKAT_Human1.05945368
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05275576
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.05124647
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.05106316
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04852740
110EZH2_27304074_Chip-Seq_ESCs_Mouse1.03517864
111* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02927364
112AHR_22903824_ChIP-Seq_MCF-7_Human1.02917680
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02462334
114RXR_22108803_ChIP-Seq_LS180_Human1.01568162
115REST_21632747_ChIP-Seq_MESCs_Mouse1.01030624
116STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00329448
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00039929
118MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99230987
119KDM2B_26808549_Chip-Seq_K562_Human0.98113587
120TP53_16413492_ChIP-PET_HCT116_Human0.97322165
121* GATA2_21666600_ChIP-Seq_HMVEC_Human0.95923382
122IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94885988
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94548270
124* GATA2_19941826_ChIP-Seq_K562_Human0.93833326
125EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92489017
126NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90399338
127STAT3_23295773_ChIP-Seq_U87_Human0.90159557
128BCAT_22108803_ChIP-Seq_LS180_Human0.89562943
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89287967
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.89165166
131SMAD4_21799915_ChIP-Seq_A2780_Human0.88782185
132* KDM2B_26808549_Chip-Seq_DND41_Human0.88435002
133EED_16625203_ChIP-ChIP_MESCs_Mouse0.88319102
134TAF15_26573619_Chip-Seq_HEK293_Human0.88069135
135CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87336753
136CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86747571
137* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86510475
138* FOXA2_19822575_ChIP-Seq_HepG2_Human0.85279106
139* TBX20_22328084_ChIP-Seq_HEART_Mouse0.83793313
140* TBX20_22080862_ChIP-Seq_HEART_Mouse0.83793313
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83350171
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.83302696
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83283154
144THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.82491737
145P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82344124
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.81661291
147* KDM2B_26808549_Chip-Seq_JURKAT_Human0.81515264
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81087896
149CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80976811
150PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80577362
151* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79949346
152OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77909773
153EP300_21415370_ChIP-Seq_HL-1_Mouse0.77808297
154Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77703340
155GATA3_27048872_Chip-Seq_THYMUS_Human0.77417291
156RUNX1_27514584_Chip-Seq_MCF-7_Human0.76498610
157SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75914954
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.75777568
159* CTCF_27219007_Chip-Seq_Bcells_Human0.75706397
160TCF4_23295773_ChIP-Seq_U87_Human0.75641630
161SMAD3_21741376_ChIP-Seq_EPCs_Human0.75595300
162SMAD3_21741376_ChIP-Seq_HESCs_Human0.75554244
163VDR_24787735_ChIP-Seq_THP-1_Human0.75526721
164CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.74766469
165LXR_22158963_ChIP-Seq_LIVER_Mouse0.74580710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004145_abnormal_muscle_electrophysio3.60262632
2MP0003436_decreased_susceptibility_to3.21524080
3MP0005451_abnormal_body_composition3.10395865
4MP0003303_peritoneal_inflammation2.83258629
5* MP0005464_abnormal_platelet_physiology2.60525443
6MP0004859_abnormal_synaptic_plasticity2.57261491
7MP0000920_abnormal_myelination2.55659521
8MP0000013_abnormal_adipose_tissue2.50103629
9MP0001835_abnormal_antigen_presentation2.46656335
10MP0004270_analgesia2.40236408
11MP0000747_muscle_weakness2.35330386
12MP0002822_catalepsy2.34294219
13MP0004130_abnormal_muscle_cell2.23145433
14MP0003172_abnormal_lysosome_physiology2.20971379
15MP0010234_abnormal_vibrissa_follicle2.18411529
16MP0004185_abnormal_adipocyte_glucose2.17962671
17MP0005410_abnormal_fertilization2.15524465
18MP0003329_amyloid_beta_deposits2.14144600
19MP0005000_abnormal_immune_tolerance2.11075979
20MP0003690_abnormal_glial_cell2.08944475
21* MP0000685_abnormal_immune_system2.05019541
22MP0000751_myopathy2.02634104
23MP0002419_abnormal_innate_immunity2.02077788
24* MP0001800_abnormal_humoral_immune2.00652163
25MP0009780_abnormal_chondrocyte_physiolo1.97232862
26MP0005025_abnormal_response_to1.92580168
27MP0004036_abnormal_muscle_relaxation1.91689985
28MP0002796_impaired_skin_barrier1.91149799
29MP0000749_muscle_degeneration1.89338713
30MP0003635_abnormal_synaptic_transmissio1.83980117
31MP0008569_lethality_at_weaning1.83293740
32MP0010678_abnormal_skin_adnexa1.83257104
33MP0005671_abnormal_response_to1.81585447
34MP0001501_abnormal_sleep_pattern1.80471576
35MP0003300_gastrointestinal_ulcer1.80174683
36MP0008260_abnormal_autophagy1.78989338
37* MP0002420_abnormal_adaptive_immunity1.76946812
38MP0008961_abnormal_basal_metabolism1.76202251
39* MP0002723_abnormal_immune_serum1.75448626
40* MP0001819_abnormal_immune_cell1.73238622
41MP0000383_abnormal_hair_follicle1.72003510
42* MP0002452_abnormal_antigen_presenting1.71118638
43MP0005670_abnormal_white_adipose1.65753138
44MP0003566_abnormal_cell_adhesion1.61462011
45MP0000003_abnormal_adipose_tissue1.61461159
46MP0001533_abnormal_skeleton_physiology1.61342514
47MP0009840_abnormal_foam_cell1.59958989
48MP0009785_altered_susceptibility_to1.57664097
49MP0009278_abnormal_bone_marrow1.56838659
50MP0004510_myositis1.56779571
51MP0003705_abnormal_hypodermis_morpholog1.56329231
52MP0002064_seizures1.54863937
53MP0009745_abnormal_behavioral_response1.54301982
54* MP0002398_abnormal_bone_marrow1.53700229
55MP0009333_abnormal_splenocyte_physiolog1.52185989
56MP0002272_abnormal_nervous_system1.48968023
57MP0003880_abnormal_central_pattern1.48807918
58MP0005375_adipose_tissue_phenotype1.48573992
59MP0001486_abnormal_startle_reflex1.44511822
60MP0003828_pulmonary_edema1.42278503
61MP0005666_abnormal_adipose_tissue1.42221473
62MP0000465_gastrointestinal_hemorrhage1.41861754
63MP0002837_dystrophic_cardiac_calcinosis1.41072652
64MP0003091_abnormal_cell_migration1.40940735
65* MP0000716_abnormal_immune_system1.39903737
66MP0010155_abnormal_intestine_physiology1.39570830
67MP0002405_respiratory_system_inflammati1.37580636
68MP0000759_abnormal_skeletal_muscle1.35454409
69MP0002396_abnormal_hematopoietic_system1.34956152
70MP0006082_CNS_inflammation1.34532692
71MP0000604_amyloidosis1.33539529
72MP0002106_abnormal_muscle_physiology1.33027246
73MP0004381_abnormal_hair_follicle1.31032164
74* MP0001851_eye_inflammation1.30654295
75MP0009046_muscle_twitch1.30529042
76MP0000858_altered_metastatic_potential1.29833077
77MP0005397_hematopoietic_system_phenotyp1.28713849
78MP0001545_abnormal_hematopoietic_system1.28713849
79* MP0002148_abnormal_hypersensitivity_rea1.25588578
80MP0002998_abnormal_bone_remodeling1.25436532
81MP0003633_abnormal_nervous_system1.23803528
82MP0002971_abnormal_brown_adipose1.23304366
83* MP0000689_abnormal_spleen_morphology1.20399799
84* MP0002722_abnormal_immune_system1.19051056
85MP0003866_abnormal_defecation1.18978848
86MP0004885_abnormal_endolymph1.17992282
87MP0001845_abnormal_inflammatory_respons1.17279781
88MP0002234_abnormal_pharynx_morphology1.16864886
89* MP0003045_fibrosis1.16015682
90MP0003656_abnormal_erythrocyte_physiolo1.15707716
91MP0000703_abnormal_thymus_morphology1.15290981
92MP0004087_abnormal_muscle_fiber1.14645530
93* MP0002429_abnormal_blood_cell1.13335308
94MP0005369_muscle_phenotype1.13179672
95MP0005166_decreased_susceptibility_to1.11869905
96MP0002132_abnormal_respiratory_system1.11436682
97MP0002063_abnormal_learning/memory/cond1.11436320
98MP0001440_abnormal_grooming_behavior1.10914530
99MP0002909_abnormal_adrenal_gland1.10225551
100MP0004742_abnormal_vestibular_system1.09119891
101MP0002933_joint_inflammation1.05728780
102MP0008438_abnormal_cutaneous_collagen1.05491245
103MP0003279_aneurysm1.05399504
104MP0002572_abnormal_emotion/affect_behav1.05049561
105* MP0004947_skin_inflammation1.04580979
106MP0005409_darkened_coat_color1.04272698
107MP0005310_abnormal_salivary_gland1.03885387
108MP0003763_abnormal_thymus_physiology1.02253572
109MP0002166_altered_tumor_susceptibility1.02148517
110MP0001958_emphysema1.02099107
111MP0005620_abnormal_muscle_contractility1.00722147
112MP0001661_extended_life_span1.00442987
113MP0008469_abnormal_protein_level1.00254404
114MP0002138_abnormal_hepatobiliary_system0.98203029
115MP0004883_abnormal_blood_vessel0.97176724
116MP0002009_preneoplasia0.97003349
117MP0002332_abnormal_exercise_endurance0.96377331
118MP0005023_abnormal_wound_healing0.96029461
119MP0005535_abnormal_body_temperature0.95267976
120MP0002269_muscular_atrophy0.95255404
121MP0005058_abnormal_lysosome_morphology0.94674058
122MP0004808_abnormal_hematopoietic_stem0.93771345
123MP0003191_abnormal_cellular_cholesterol0.93249571
124MP0000249_abnormal_blood_vessel0.92962199
125MP0002118_abnormal_lipid_homeostasis0.92154466
126MP0003634_abnormal_glial_cell0.92092942
127MP0002060_abnormal_skin_morphology0.91713173
128* MP0001765_abnormal_ion_homeostasis0.91569513
129MP0008874_decreased_physiological_sensi0.90090001
130MP0005423_abnormal_somatic_nervous0.89049897
131MP0005167_abnormal_blood-brain_barrier0.88019192
132MP0002254_reproductive_system_inflammat0.87656608
133MP0003075_altered_response_to0.87061421
134MP0001666_abnormal_nutrient_absorption0.86874772
135MP0003950_abnormal_plasma_membrane0.86275301
136MP0002139_abnormal_hepatobiliary_system0.86108474
137MP0003724_increased_susceptibility_to0.85636233
138MP0003631_nervous_system_phenotype0.85531151
139MP0005164_abnormal_response_to0.85235874
140MP0005275_abnormal_skin_tensile0.84401308
141MP0004043_abnormal_pH_regulation0.84034169
142MP0005076_abnormal_cell_differentiation0.83633899
143MP0002877_abnormal_melanocyte_morpholog0.82976857
144MP0000647_abnormal_sebaceous_gland0.82584076
145MP0002734_abnormal_mechanical_nocicepti0.81000791
146MP0001502_abnormal_circadian_rhythm0.80937264
147MP0002108_abnormal_muscle_morphology0.80869684
148MP0010771_integument_phenotype0.80227103
149MP0001216_abnormal_epidermal_layer0.79487784
150MP0001849_ear_inflammation0.79170464
151MP0003195_calcinosis0.78977633
152MP0005334_abnormal_fat_pad0.78577381
153MP0003453_abnormal_keratinocyte_physiol0.76923875
154* MP0001790_abnormal_immune_system0.74551819
155* MP0005387_immune_system_phenotype0.74551819
156MP0002229_neurodegeneration0.74489168
157MP0002006_tumorigenesis0.74070665
158MP0004233_abnormal_muscle_weight0.72695255
159MP0001970_abnormal_pain_threshold0.72558751
160MP0000427_abnormal_hair_cycle0.72470454
161MP0003646_muscle_fatigue0.71258939
162MP0003183_abnormal_peptide_metabolism0.70330307
163MP0000579_abnormal_nail_morphology0.69233674
164MP0002067_abnormal_sensory_capabilities0.68574799

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.90357703
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.53546859
3Nemaline bodies (HP:0003798)5.45696226
4* Exercise-induced myalgia (HP:0003738)4.58843663
5Type 1 muscle fiber predominance (HP:0003803)4.45977012
6Muscle hypertrophy of the lower extremities (HP:0008968)4.11842463
7Neurofibrillary tangles (HP:0002185)4.02319646
8Myopathic facies (HP:0002058)4.02094085
9Difficulty running (HP:0009046)3.95973113
10Eczematoid dermatitis (HP:0000976)3.95755192
11Round ear (HP:0100830)3.92392985
12Distal arthrogryposis (HP:0005684)3.83062264
13Calf muscle hypertrophy (HP:0008981)3.60261436
14* Hyporeflexia of lower limbs (HP:0002600)3.59699134
15Prolonged bleeding time (HP:0003010)3.58300378
16Ulnar deviation of the wrist (HP:0003049)3.29985830
17Cerebral inclusion bodies (HP:0100314)3.29176895
18Exercise-induced muscle cramps (HP:0003710)3.10357646
19Increased IgE level (HP:0003212)3.06609977
20Muscle fiber splitting (HP:0003555)3.00967182
21Nasal polyposis (HP:0100582)3.00959875
22Hyperkalemia (HP:0002153)3.00885104
23Abnormality of macrophages (HP:0004311)3.00398590
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.98805841
25Ankle clonus (HP:0011448)2.87980230
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.87681797
27Gingival bleeding (HP:0000225)2.86391550
28Absent/shortened dynein arms (HP:0200106)2.84700242
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.84700242
30Myositis (HP:0100614)2.82234031
31Recurrent abscess formation (HP:0002722)2.81927312
32Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.78631607
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.78631607
34Purpura (HP:0000979)2.76687911
35Supranuclear gaze palsy (HP:0000605)2.72435891
36Spontaneous hematomas (HP:0007420)2.70128117
37* Epistaxis (HP:0000421)2.70087825
38Abnormal respiratory motile cilium physiology (HP:0012261)2.69011905
39Recurrent bacterial skin infections (HP:0005406)2.68775358
40Neck muscle weakness (HP:0000467)2.67156961
41Abnormality of the nasal mucosa (HP:0000433)2.66631984
42Cellulitis (HP:0100658)2.60270412
43Frequent falls (HP:0002359)2.58861580
44Petechiae (HP:0000967)2.56803869
45Elevated erythrocyte sedimentation rate (HP:0003565)2.56528255
46Abnormal platelet volume (HP:0011876)2.54683466
47Bulbar palsy (HP:0001283)2.54443725
48Dysostosis multiplex (HP:0000943)2.53586583
49Facial diplegia (HP:0001349)2.52392318
50Menorrhagia (HP:0000132)2.44918400
51EMG: myopathic abnormalities (HP:0003458)2.43000876
52Orchitis (HP:0100796)2.42763626
53Abnormal ciliary motility (HP:0012262)2.42667807
54Recurrent gram-negative bacterial infections (HP:0005420)2.41959181
55Intention tremor (HP:0002080)2.41644886
56* Abnormality of skeletal muscle fiber size (HP:0012084)2.41310494
57Recurrent fungal infections (HP:0002841)2.39445329
58Abnormality of the neuromuscular junction (HP:0003398)2.39400590
59Fatigable weakness (HP:0003473)2.39400590
60Meningitis (HP:0001287)2.38315761
61Gastrointestinal infarctions (HP:0005244)2.36736505
62Gastrointestinal inflammation (HP:0004386)2.35348167
63Absent phalangeal crease (HP:0006109)2.34644789
64Myoglobinuria (HP:0002913)2.32665133
65Deep venous thrombosis (HP:0002625)2.32577407
66Chronic otitis media (HP:0000389)2.30958290
67Obstructive sleep apnea (HP:0002870)2.29599303
68Papilledema (HP:0001085)2.29412996
69Colitis (HP:0002583)2.27679380
70Male infertility (HP:0003251)2.26319401
71Rhinitis (HP:0012384)2.26215275
72Inflammation of the large intestine (HP:0002037)2.25709898
73* Increased variability in muscle fiber diameter (HP:0003557)2.25699397
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.24796361
75* Muscle stiffness (HP:0003552)2.23243103
76Gowers sign (HP:0003391)2.21558381
77Asymmetric septal hypertrophy (HP:0001670)2.20249080
78Spastic gait (HP:0002064)2.19793884
79Focal motor seizures (HP:0011153)2.19079808
80Increased mean platelet volume (HP:0011877)2.16057007
81Obstructive lung disease (HP:0006536)2.15655358
82Chronic obstructive pulmonary disease (HP:0006510)2.15655358
83Abnormality of the corticospinal tract (HP:0002492)2.15497392
84Polycythemia (HP:0001901)2.15471890
85Calcaneovalgus deformity (HP:0001848)2.15189945
86Onion bulb formation (HP:0003383)2.14117148
87Cerebral aneurysm (HP:0004944)2.13990649
88Stridor (HP:0010307)2.13448758
89Abnormal finger flexion creases (HP:0006143)2.12418274
90Distal lower limb muscle weakness (HP:0009053)2.11457712
91Recurrent viral infections (HP:0004429)2.11098503
92Pustule (HP:0200039)2.11013656
93Hemorrhage of the eye (HP:0011885)2.10400141
94Stomatitis (HP:0010280)2.10310086
95Mediastinal lymphadenopathy (HP:0100721)2.10293333
96Urinary glycosaminoglycan excretion (HP:0003541)2.09243164
97Mucopolysacchariduria (HP:0008155)2.09243164
98Rhabdomyolysis (HP:0003201)2.08324162
99Distal lower limb amyotrophy (HP:0008944)2.07757672
100Chest pain (HP:0100749)2.07576028
101Gingivitis (HP:0000230)2.06993072
102Neuronal loss in central nervous system (HP:0002529)2.06798133
103Agammaglobulinemia (HP:0004432)2.06008451
104Abnormality of the calf musculature (HP:0001430)2.05049818
105Fatigue (HP:0012378)2.03585662
106Clumsiness (HP:0002312)2.03427496
107Vasculitis (HP:0002633)2.02886827
108Abnormality of mucopolysaccharide metabolism (HP:0011020)2.02478190
109Abnormality of polysaccharide metabolism (HP:0011012)2.02478190
110Abnormality of glycosaminoglycan metabolism (HP:0004371)2.02478190
111Panhypogammaglobulinemia (HP:0003139)2.01697872
112Optic neuritis (HP:0100653)2.01591226
113Retrobulbar optic neuritis (HP:0100654)2.01591226
114Dysmetria (HP:0001310)2.01293577
115Abnormal respiratory motile cilium morphology (HP:0005938)1.99140384
116Abnormal respiratory epithelium morphology (HP:0012253)1.99140384
117Amyloidosis (HP:0011034)1.97183561
118Rapidly progressive (HP:0003678)1.96858762
119Hyperlipoproteinemia (HP:0010980)1.95648797
120Deformed tarsal bones (HP:0008119)1.93270695
121Urinary urgency (HP:0000012)1.93207864
122Nonprogressive disorder (HP:0003680)1.92738012
123Abnormality of the common coagulation pathway (HP:0010990)1.92233926
124Systemic lupus erythematosus (HP:0002725)1.92168366
125Peritonitis (HP:0002586)1.91711167
126Joint hemorrhage (HP:0005261)1.91650694
127Papilloma (HP:0012740)1.91166773
128Verrucae (HP:0200043)1.91166773
129Recurrent skin infections (HP:0001581)1.91047367
130Visual hallucinations (HP:0002367)1.90477268
131Increased connective tissue (HP:0009025)1.90093169
132Milia (HP:0001056)1.90058277
133Gastrointestinal stroma tumor (HP:0100723)1.89899469
134Difficulty climbing stairs (HP:0003551)1.88868522
135Granulocytopenia (HP:0001913)1.88612814
136Lower limb muscle weakness (HP:0007340)1.87092337
137Insidious onset (HP:0003587)1.86893770
138Termporal pattern (HP:0011008)1.86893770
139Rimmed vacuoles (HP:0003805)1.85657788
140Infertility (HP:0000789)1.85303915
141Impaired platelet aggregation (HP:0003540)1.83598473
142Abnormal platelet function (HP:0011869)1.83598473
143Hypertriglyceridemia (HP:0002155)1.82949838
144Chronic bronchitis (HP:0004469)1.82664802
145Broad face (HP:0000283)1.82226309
146Interstitial pulmonary disease (HP:0006530)1.82020154
147Arterial thrombosis (HP:0004420)1.81890086
148Malignant hyperthermia (HP:0002047)1.81516713
149Bundle branch block (HP:0011710)1.81137833
150Proximal amyotrophy (HP:0007126)1.80684723
151Urticaria (HP:0001025)1.79975376
152Atonic seizures (HP:0010819)1.78139738
153Dilatation of the ascending aorta (HP:0005111)1.77768036
154Bruising susceptibility (HP:0000978)1.77645977
155Generalized tonic-clonic seizures (HP:0002069)1.74647986
156Achilles tendon contracture (HP:0001771)1.74559241
157Scapular winging (HP:0003691)1.74247906
158Slender build (HP:0001533)1.74134811
159Myotonia (HP:0002486)1.73897932
160Lower limb amyotrophy (HP:0007210)1.73870350
161Keratoconjunctivitis sicca (HP:0001097)1.73636931
162Loss of speech (HP:0002371)1.73399662
163Bronchiectasis (HP:0002110)1.72885599
164EMG: neuropathic changes (HP:0003445)1.72598360
165Slow saccadic eye movements (HP:0000514)1.72495734
166Urinary bladder sphincter dysfunction (HP:0002839)1.71949011
167Increased cerebral lipofuscin (HP:0011813)1.71599658
168Recurrent cutaneous fungal infections (HP:0011370)1.71362556
169Chronic mucocutaneous candidiasis (HP:0002728)1.71362556
170Increased serum ferritin (HP:0003281)1.71203851
171Encephalitis (HP:0002383)1.70728895
172Abnormality of glycosphingolipid metabolism (HP:0004343)1.70447737
173Clonus (HP:0002169)1.69118187
174Weak cry (HP:0001612)1.68639380
175Hemiplegia (HP:0002301)1.67246134
176Spastic tetraparesis (HP:0001285)1.67018878
177Parakeratosis (HP:0001036)1.66195133
178Acanthosis nigricans (HP:0000956)1.65202830
179Lip pit (HP:0100267)1.64883819
180Focal seizures (HP:0007359)1.64288321
181Action tremor (HP:0002345)1.61795801
182T lymphocytopenia (HP:0005403)1.59972375

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN2.88133018
2EPHB12.60837202
3STK392.05833095
4CAMK1G1.87992384
5TTN1.87209600
6PIK3CG1.86779999
7MAPKAPK51.77501215
8RIPK11.71587742
9MAP4K11.69274127
10DMPK1.61057066
11FGFR21.59821889
12TNIK1.59603027
13PHKG21.57160934
14PHKG11.57160934
15ICK1.54689127
16NTRK31.53762869
17MAP3K21.53290271
18MAP3K31.52571589
19MAPK151.51566638
20TAOK31.51416395
21TYRO31.50248094
22CDK121.48485504
23ITK1.47297050
24PNCK1.43690224
25EPHA41.43292186
26TNK21.42578974
27BLK1.40142482
28TRIB31.40077769
29TBK11.39193568
30MAP3K131.37200293
31GRK61.35751282
32BMPR21.34484503
33MAP3K71.33835427
34BTK1.33809587
35MAP3K91.33505980
36MAP3K141.33071590
37SMG11.30429740
38IRAK41.30338563
39WNK11.29552957
40KSR21.28093391
41RIPK41.21636415
42JAK31.21239229
43PRKCH1.19320539
44OXSR11.18230385
45MARK21.17400057
46TXK1.15271364
47FES1.14487468
48MAP3K11.13725572
49NTRK11.11088446
50PDK11.07034036
51PRKD31.05110244
52IRAK31.03261958
53TAOK21.02979698
54PDK41.02216336
55PDK31.02216336
56NEK60.98848779
57JAK10.98379860
58INSRR0.97567531
59PRKCQ0.96363528
60RET0.95374730
61SIK30.94242908
62MAP2K40.93766434
63PDPK10.91754332
64PTK60.91154682
65STK110.91110389
66TAOK10.88805497
67MAPK120.88537921
68CSF1R0.87553730
69MAP3K110.87280612
70HIPK20.87156904
71MAPK110.84744500
72PAK60.84382432
73CDC42BPA0.84304878
74CAMK1D0.83690219
75SIK20.83010306
76SIK10.81315868
77STK380.81215653
78PTK2B0.80709388
79ERN10.79417992
80ARAF0.79186097
81MAP3K60.78386796
82NEK90.76760222
83MET0.76268461
84PDK20.75660001
85FGFR40.74134817
86KIT0.73976707
87PIK3CA0.72286057
88PKN10.72163219
89SGK30.72139700
90NTRK20.72081817
91IKBKE0.71634849
92MAP2K30.69691994
93CDK50.69413948
94MAP3K40.69250569
95DAPK20.67896174
96PRKD20.67643700
97MAP3K100.67355976
98PRPF4B0.67290895
99HCK0.66920176
100CSK0.66497312
101JAK20.66059346
102PRKD10.66039637
103MOS0.65438224
104TGFBR20.65053921
105MAPK70.63868107
106EPHA30.63244589
107LYN0.63063831
108MUSK0.61887626
109PDGFRB0.61735382
110CAMKK10.60442423
111MARK30.59572486
112BMX0.59138382
113TRPM70.57155236
114MST1R0.57093963
115PKN20.57073506
116IRAK10.57005392
117EEF2K0.56871722
118FYN0.56291156
119TYK20.56191561
120WNK40.53529088
121STK100.53525925
122TEC0.53291096
123FGFR30.53054685
124MAP2K20.52860211
125TESK20.51728044
126IKBKB0.51036838
127PINK10.50531393
128SYK0.50242381
129CDK190.49689731
130LCK0.49477934
131LRRK20.48944422
132SGK10.48687241
133CAMK2G0.48458871
134PAK30.48264391
135LMTK20.48056174
136ZAP700.47475813
137RAF10.46967913
138NME10.46356096
139IRAK20.46179756
140FGR0.45781684
141MAPK40.44882813
142NLK0.42693935
143MTOR0.41467479
144RPS6KA20.40762175
145RPS6KC10.39004611

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.12991689
2Acute myeloid leukemia_Homo sapiens_hsa052211.92509257
3Leishmaniasis_Homo sapiens_hsa051401.74126021
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.70565116
5Renin secretion_Homo sapiens_hsa049241.69157845
6Staphylococcus aureus infection_Homo sapiens_hsa051501.63876149
7Non-small cell lung cancer_Homo sapiens_hsa052231.61978943
8Salivary secretion_Homo sapiens_hsa049701.60877663
9Gastric acid secretion_Homo sapiens_hsa049711.58254636
10Dorso-ventral axis formation_Homo sapiens_hsa043201.50598247
11Chronic myeloid leukemia_Homo sapiens_hsa052201.41560559
12Oxytocin signaling pathway_Homo sapiens_hsa049211.40135372
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.39833912
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.38460320
15Long-term potentiation_Homo sapiens_hsa047201.38302326
16Circadian entrainment_Homo sapiens_hsa047131.38057510
17Amphetamine addiction_Homo sapiens_hsa050311.34713688
18Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33106774
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.32991532
20Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32681481
21Olfactory transduction_Homo sapiens_hsa047401.31992630
22GABAergic synapse_Homo sapiens_hsa047271.31682353
23Insulin secretion_Homo sapiens_hsa049111.30968261
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30779953
25T cell receptor signaling pathway_Homo sapiens_hsa046601.29823890
26Morphine addiction_Homo sapiens_hsa050321.29585334
27Pancreatic cancer_Homo sapiens_hsa052121.29585185
28Tuberculosis_Homo sapiens_hsa051521.29220224
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27617085
30Toxoplasmosis_Homo sapiens_hsa051451.26073895
31Allograft rejection_Homo sapiens_hsa053301.25809142
32Glutamatergic synapse_Homo sapiens_hsa047241.25778684
33Graft-versus-host disease_Homo sapiens_hsa053321.25311219
34Pancreatic secretion_Homo sapiens_hsa049721.24339799
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.21955686
36Autoimmune thyroid disease_Homo sapiens_hsa053201.21080366
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.18735223
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18330338
39* Calcium signaling pathway_Homo sapiens_hsa040201.18233411
40Fatty acid elongation_Homo sapiens_hsa000621.18178470
41Type II diabetes mellitus_Homo sapiens_hsa049301.15248703
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.13200614
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12643916
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11981908
45Cholinergic synapse_Homo sapiens_hsa047251.11889692
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.11199155
47Measles_Homo sapiens_hsa051621.10782770
48Fatty acid biosynthesis_Homo sapiens_hsa000611.10725465
49Hematopoietic cell lineage_Homo sapiens_hsa046401.10486288
50Viral myocarditis_Homo sapiens_hsa054161.10216487
51Cocaine addiction_Homo sapiens_hsa050301.09366464
52GnRH signaling pathway_Homo sapiens_hsa049121.07029436
53cAMP signaling pathway_Homo sapiens_hsa040241.05975960
54Dopaminergic synapse_Homo sapiens_hsa047281.04480710
55Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04274731
56Malaria_Homo sapiens_hsa051441.03693425
57TNF signaling pathway_Homo sapiens_hsa046681.03469209
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99942539
59ABC transporters_Homo sapiens_hsa020100.99912282
60Long-term depression_Homo sapiens_hsa047300.99497938
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.98193746
62Influenza A_Homo sapiens_hsa051640.97545913
63Insulin resistance_Homo sapiens_hsa049310.97513444
64mTOR signaling pathway_Homo sapiens_hsa041500.96455265
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96148545
66Endometrial cancer_Homo sapiens_hsa052130.95084886
67VEGF signaling pathway_Homo sapiens_hsa043700.94593493
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94552888
69Complement and coagulation cascades_Homo sapiens_hsa046100.94333373
70Hepatitis B_Homo sapiens_hsa051610.94035542
71Nitrogen metabolism_Homo sapiens_hsa009100.92074229
72Hepatitis C_Homo sapiens_hsa051600.90756811
73B cell receptor signaling pathway_Homo sapiens_hsa046620.90719333
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90618029
75Sphingolipid metabolism_Homo sapiens_hsa006000.90465500
76Estrogen signaling pathway_Homo sapiens_hsa049150.90326546
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89253127
78Taste transduction_Homo sapiens_hsa047420.87320345
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87173641
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.87037041
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.85647764
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85315245
83Glucagon signaling pathway_Homo sapiens_hsa049220.84536674
84Ovarian steroidogenesis_Homo sapiens_hsa049130.84235234
85Dilated cardiomyopathy_Homo sapiens_hsa054140.84010021
86Serotonergic synapse_Homo sapiens_hsa047260.83385560
87Circadian rhythm_Homo sapiens_hsa047100.83093090
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.82946798
89Inositol phosphate metabolism_Homo sapiens_hsa005620.82584826
90Pertussis_Homo sapiens_hsa051330.82480110
91Type I diabetes mellitus_Homo sapiens_hsa049400.81304281
92Osteoclast differentiation_Homo sapiens_hsa043800.80553786
93Choline metabolism in cancer_Homo sapiens_hsa052310.78818682
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78617451
95Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76295340
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75675761
97Glycerolipid metabolism_Homo sapiens_hsa005610.75507092
98Nicotine addiction_Homo sapiens_hsa050330.74879366
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.74154825
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73740418
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.73403056
102Apoptosis_Homo sapiens_hsa042100.73374063
103* Platelet activation_Homo sapiens_hsa046110.73016849
104Pentose phosphate pathway_Homo sapiens_hsa000300.72453172
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72050384
106Notch signaling pathway_Homo sapiens_hsa043300.71402050
107Bile secretion_Homo sapiens_hsa049760.71116928
108FoxO signaling pathway_Homo sapiens_hsa040680.71092623
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69917436
110Antigen processing and presentation_Homo sapiens_hsa046120.69036904
111Endocytosis_Homo sapiens_hsa041440.69000016
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68663571
113MAPK signaling pathway_Homo sapiens_hsa040100.68416124
114ErbB signaling pathway_Homo sapiens_hsa040120.67783492
115AMPK signaling pathway_Homo sapiens_hsa041520.67410462
116Ether lipid metabolism_Homo sapiens_hsa005650.66900766
117Prion diseases_Homo sapiens_hsa050200.66641952
118HIF-1 signaling pathway_Homo sapiens_hsa040660.64828763
119Axon guidance_Homo sapiens_hsa043600.64485073
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.64330822
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63912124
122Sulfur metabolism_Homo sapiens_hsa009200.63851384
123Primary immunodeficiency_Homo sapiens_hsa053400.62999853
124Thyroid hormone synthesis_Homo sapiens_hsa049180.62149927
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61937977
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61755390
127Herpes simplex infection_Homo sapiens_hsa051680.61455038
128Fatty acid metabolism_Homo sapiens_hsa012120.61148415
129Shigellosis_Homo sapiens_hsa051310.60839432
130Insulin signaling pathway_Homo sapiens_hsa049100.60546831
131Chemokine signaling pathway_Homo sapiens_hsa040620.60504450
132Renal cell carcinoma_Homo sapiens_hsa052110.60245519
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60104687
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.59942586
135Synaptic vesicle cycle_Homo sapiens_hsa047210.59633804
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58688590
137Phagosome_Homo sapiens_hsa041450.57538168
138PPAR signaling pathway_Homo sapiens_hsa033200.57407841
139Small cell lung cancer_Homo sapiens_hsa052220.57116373
140Amoebiasis_Homo sapiens_hsa051460.57058965
141Prostate cancer_Homo sapiens_hsa052150.56606632
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54680311
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.54347525
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52657600
145Melanogenesis_Homo sapiens_hsa049160.52615229
146Lysosome_Homo sapiens_hsa041420.52504416
147Thyroid cancer_Homo sapiens_hsa052160.51969983
148Prolactin signaling pathway_Homo sapiens_hsa049170.50025392
149Focal adhesion_Homo sapiens_hsa045100.48252542
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.48205539
151Gap junction_Homo sapiens_hsa045400.47420846
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46056946
153Glioma_Homo sapiens_hsa052140.44755927

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