STIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.36194101
2purine nucleobase biosynthetic process (GO:0009113)5.31509333
3COPI coating of Golgi vesicle (GO:0048205)5.00176627
4Golgi transport vesicle coating (GO:0048200)5.00176627
5ribosome assembly (GO:0042255)4.94315423
6establishment of integrated proviral latency (GO:0075713)4.79972716
7mitotic metaphase plate congression (GO:0007080)4.77269313
8formation of translation preinitiation complex (GO:0001731)4.72923866
9protein localization to kinetochore (GO:0034501)4.67785328
10regulation of translational fidelity (GO:0006450)4.45440035
11ribosome biogenesis (GO:0042254)4.42880789
12DNA replication checkpoint (GO:0000076)4.36361732
13DNA unwinding involved in DNA replication (GO:0006268)4.33712528
14DNA replication initiation (GO:0006270)4.32793487
15mitotic nuclear envelope disassembly (GO:0007077)4.31511610
16nuclear pore organization (GO:0006999)4.29765523
17DNA strand elongation involved in DNA replication (GO:0006271)4.27213031
18IMP biosynthetic process (GO:0006188)4.19463269
19spliceosomal tri-snRNP complex assembly (GO:0000244)4.09539403
20regulation of spindle organization (GO:0090224)4.09501883
21nuclear envelope disassembly (GO:0051081)4.04812304
22membrane disassembly (GO:0030397)4.04812304
23DNA strand elongation (GO:0022616)4.03678178
24regulation of translational termination (GO:0006449)4.03280251
25DNA replication-dependent nucleosome assembly (GO:0006335)4.01407966
26DNA replication-dependent nucleosome organization (GO:0034723)4.01407966
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.97558208
28metaphase plate congression (GO:0051310)3.95463295
29protein complex localization (GO:0031503)3.94136995
30establishment of viral latency (GO:0019043)3.89023299
31maturation of SSU-rRNA (GO:0030490)3.88835414
32protein localization to chromosome, centromeric region (GO:0071459)3.88156882
33mitotic sister chromatid segregation (GO:0000070)3.87094347
34nuclear pore complex assembly (GO:0051292)3.87067647
35folic acid-containing compound biosynthetic process (GO:0009396)3.82942793
36proline biosynthetic process (GO:0006561)3.80623105
37folic acid metabolic process (GO:0046655)3.77946383
38regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77861220
39telomere maintenance via semi-conservative replication (GO:0032201)3.69307603
40positive regulation of chromosome segregation (GO:0051984)3.65985806
41nucleobase-containing small molecule interconversion (GO:0015949)3.61889782
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.58178898
43negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.56634562
44IMP metabolic process (GO:0046040)3.56258027
45ribonucleoprotein complex biogenesis (GO:0022613)3.56048196
46spliceosomal snRNP assembly (GO:0000387)3.49057852
47DNA topological change (GO:0006265)3.46095414
48sister chromatid segregation (GO:0000819)3.44426310
49negative regulation of chromosome segregation (GO:0051985)3.43352425
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42810799
51chromosome condensation (GO:0030261)3.42296828
52establishment of chromosome localization (GO:0051303)3.42161167
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41761889
54spindle checkpoint (GO:0031577)3.40556806
55regulation of mitotic spindle organization (GO:0060236)3.38745695
56negative regulation of mitotic sister chromatid separation (GO:2000816)3.38592520
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.38592520
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.38592520
59negative regulation of sister chromatid segregation (GO:0033046)3.38592520
60regulation of chromosome segregation (GO:0051983)3.38027956
61regulation of centrosome cycle (GO:0046605)3.37251552
62mitotic spindle assembly checkpoint (GO:0007094)3.37028956
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.34474384
64mitotic spindle checkpoint (GO:0071174)3.34452477
65cellular protein complex localization (GO:0034629)3.34001762
66rRNA processing (GO:0006364)3.33761913
67spindle assembly checkpoint (GO:0071173)3.33664603
68nuclear envelope organization (GO:0006998)3.33156603
69telomere maintenance via recombination (GO:0000722)3.32644614
70rRNA modification (GO:0000154)3.32301936
71CENP-A containing nucleosome assembly (GO:0034080)3.29618930
72peptidyl-arginine methylation (GO:0018216)3.28999948
73peptidyl-arginine N-methylation (GO:0035246)3.28999948
74heterochromatin organization (GO:0070828)3.28689816
75attachment of spindle microtubules to kinetochore (GO:0008608)3.28570442
76negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.27344388
77proteasome assembly (GO:0043248)3.26891761
78mitotic sister chromatid cohesion (GO:0007064)3.26727515
79chromatin remodeling at centromere (GO:0031055)3.26516661
80mitotic recombination (GO:0006312)3.25566023
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25175003
82mitotic chromosome condensation (GO:0007076)3.24275061
83rRNA metabolic process (GO:0016072)3.23909383
84DNA replication-independent nucleosome organization (GO:0034724)3.21175706
85DNA replication-independent nucleosome assembly (GO:0006336)3.21175706
86nuclear envelope reassembly (GO:0031468)3.20182104
87mitotic nuclear envelope reassembly (GO:0007084)3.20182104
88maturation of 5.8S rRNA (GO:0000460)3.17000805
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.16788208
90peptidyl-arginine omega-N-methylation (GO:0035247)3.16785409
91telomere maintenance via telomere lengthening (GO:0010833)3.15848986
92tRNA aminoacylation for protein translation (GO:0006418)3.15765283
93pore complex assembly (GO:0046931)3.13489304
94ribosomal large subunit biogenesis (GO:0042273)3.13240452
95DNA duplex unwinding (GO:0032508)3.12817452
96retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.12773388
97non-recombinational repair (GO:0000726)3.11829730
98double-strand break repair via nonhomologous end joining (GO:0006303)3.11829730
99DNA geometric change (GO:0032392)3.11652655
100positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.11576964
101G1/S transition of mitotic cell cycle (GO:0000082)3.10515441
102cell cycle G1/S phase transition (GO:0044843)3.10515441
103DNA conformation change (GO:0071103)3.09983005
104protein maturation by protein folding (GO:0022417)3.09334692
105protein export from nucleus (GO:0006611)3.07117281
106regulation of mitotic sister chromatid separation (GO:0010965)3.07054883
107regulation of mitotic sister chromatid segregation (GO:0033047)3.07054883
108regulation of sister chromatid segregation (GO:0033045)3.07054883
109maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.06707341
110histone arginine methylation (GO:0034969)3.05059253
111regulation of translation in response to stress (GO:0043555)3.03831099
112kinetochore organization (GO:0051383)3.03631414
113negative regulation of ligase activity (GO:0051352)3.03538151
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.03538151
115somatic hypermutation of immunoglobulin genes (GO:0016446)3.03006013
116somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03006013
117tRNA aminoacylation (GO:0043039)3.02600676
118amino acid activation (GO:0043038)3.02600676
119negative regulation of mRNA processing (GO:0050686)3.02493572
120DNA deamination (GO:0045006)3.01876421
121regulation of mammary gland epithelial cell proliferation (GO:0033599)3.01822661
122histone-serine phosphorylation (GO:0035404)2.99587127
123histone exchange (GO:0043486)2.99203460
124protein localization to chromosome (GO:0034502)2.98212770
125pentose-phosphate shunt (GO:0006098)2.97967389
126regulation of double-strand break repair via homologous recombination (GO:0010569)2.97556008
127termination of RNA polymerase I transcription (GO:0006363)2.97423902
128regulation of sister chromatid cohesion (GO:0007063)2.97288744
129pseudouridine synthesis (GO:0001522)2.96301826
130chaperone-mediated protein complex assembly (GO:0051131)2.95201026
131transcription elongation from RNA polymerase I promoter (GO:0006362)2.94886246
132DNA packaging (GO:0006323)2.94575575
133transcription-coupled nucleotide-excision repair (GO:0006283)2.93759617
134nucleotide-excision repair, DNA gap filling (GO:0006297)2.93634195
135protein retention in ER lumen (GO:0006621)2.92134202
136nucleosome disassembly (GO:0006337)2.84816604
137protein-DNA complex disassembly (GO:0032986)2.84816604
138negative regulation of mRNA metabolic process (GO:1903312)2.84320740
139regulation of RNA export from nucleus (GO:0046831)2.82861583
140NADPH regeneration (GO:0006740)2.82098880
141DNA ligation (GO:0006266)2.79295342
142viral mRNA export from host cell nucleus (GO:0046784)2.76414568
143regulation of translational elongation (GO:0006448)2.74714264
144chromosome segregation (GO:0007059)2.72380986
145L-serine metabolic process (GO:0006563)2.72294639
146de novo protein folding (GO:0006458)2.70351666
147rRNA transcription (GO:0009303)2.68191613
148positive regulation of DNA-dependent DNA replication (GO:2000105)2.65979848
149de novo posttranslational protein folding (GO:0051084)2.65128757
150negative regulation of RNA splicing (GO:0033119)2.58517544
151mitochondrial fusion (GO:0008053)2.57434082
152mRNA splicing, via spliceosome (GO:0000398)2.56530393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.04743969
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.29701532
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.12164382
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.67210007
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.46798740
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20680816
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.97019944
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95427898
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.92373935
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.90462233
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.86296452
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85866135
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83900482
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.80045695
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.62126525
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.52347011
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42121439
18AR_21909140_ChIP-Seq_LNCAP_Human2.34732084
19* XRN2_22483619_ChIP-Seq_HELA_Human2.34204228
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21934566
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18284114
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17256522
23VDR_23849224_ChIP-Seq_CD4+_Human2.11470472
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.07265757
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.07258294
26* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04045352
27MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02490536
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02378677
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.98995300
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98026481
31GABP_19822575_ChIP-Seq_HepG2_Human1.94013875
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91341990
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88507268
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.87272025
35DCP1A_22483619_ChIP-Seq_HELA_Human1.84273531
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.82151272
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77611692
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76378637
39TTF2_22483619_ChIP-Seq_HELA_Human1.74467412
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71914161
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71763098
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.70867963
43CIITA_25753668_ChIP-Seq_RAJI_Human1.67972875
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63775163
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61101681
46* KDM5A_27292631_Chip-Seq_BREAST_Human1.61082288
47* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.57783830
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.51144442
49* MYC_22102868_ChIP-Seq_BL_Human1.50744657
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46834948
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.43529094
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41323206
53* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40905966
54* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39306030
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39001463
56CLOCK_20551151_ChIP-Seq_293T_Human1.38577080
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36105872
58* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35996041
59ELK1_19687146_ChIP-ChIP_HELA_Human1.32470951
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31572382
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31147083
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24261313
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23086645
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22420133
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21329443
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20790245
67* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20017543
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18615765
69TFEB_21752829_ChIP-Seq_HELA_Human1.17155608
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.16846086
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15086033
72TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15052273
73* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14298894
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.14251356
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.14007663
76PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13961920
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.13015371
78* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12015733
79HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11859954
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11429148
81RACK7_27058665_Chip-Seq_MCF-7_Human1.10783662
82SALL1_21062744_ChIP-ChIP_HESCs_Human1.10716077
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10347201
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.10222541
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10106841
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10079675
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09970269
88SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09375156
89TCF3_18692474_ChIP-Seq_MEFs_Mouse1.07333626
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.06954245
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05964693
92* CHD1_26751641_Chip-Seq_LNCaP_Human1.05900131
93* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05099206
94* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04260474
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03904564
96ATF3_27146783_Chip-Seq_COLON_Human1.02054698
97VDR_21846776_ChIP-Seq_THP-1_Human1.01157466
98ZNF263_19887448_ChIP-Seq_K562_Human1.00178210
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99715891
100TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99482628
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98896793
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98625438
103SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98499094
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98068265
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97274653
106* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95516107
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95338770
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.94559336
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93985090
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93917598
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.93558573
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.93558573
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.93558573
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93289412
115SOX17_20123909_ChIP-Seq_XEN_Mouse0.92802844
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92170976
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91855324
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.91652866
119* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90421074
120TET1_21451524_ChIP-Seq_MESCs_Mouse0.88136513
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.86139233
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.83564968
123POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.81743565
124* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80359139

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.98006182
2MP0003111_abnormal_nucleus_morphology5.16307140
3MP0004957_abnormal_blastocyst_morpholog4.83778214
4MP0010094_abnormal_chromosome_stability4.71316149
5MP0003077_abnormal_cell_cycle4.21012232
6MP0008057_abnormal_DNA_replication3.51679610
7MP0008058_abnormal_DNA_repair3.27568631
8MP0003123_paternal_imprinting3.26740163
9MP0002877_abnormal_melanocyte_morpholog3.05407967
10MP0001730_embryonic_growth_arrest2.94390467
11MP0008932_abnormal_embryonic_tissue2.88801663
12MP0008007_abnormal_cellular_replicative2.87740493
13MP0010234_abnormal_vibrissa_follicle2.67359728
14MP0010352_gastrointestinal_tract_polyps2.51346797
15MP0000350_abnormal_cell_proliferation2.49414750
16MP0008877_abnormal_DNA_methylation2.39478533
17MP0003718_maternal_effect2.36970318
18MP0005380_embryogenesis_phenotype2.21601086
19MP0001672_abnormal_embryogenesis/_devel2.21601086
20MP0003786_premature_aging2.18054305
21MP0005451_abnormal_body_composition2.13467996
22MP0010307_abnormal_tumor_latency2.07741831
23MP0001697_abnormal_embryo_size2.03936962
24MP0003984_embryonic_growth_retardation2.00450978
25MP0002088_abnormal_embryonic_growth/wei1.96431484
26MP0002080_prenatal_lethality1.93809840
27MP0004185_abnormal_adipocyte_glucose1.86004056
28MP0002085_abnormal_embryonic_tissue1.83194816
29MP0002084_abnormal_developmental_patter1.78412573
30MP0002396_abnormal_hematopoietic_system1.70861375
31MP0002086_abnormal_extraembryonic_tissu1.63586842
32MP0004197_abnormal_fetal_growth/weight/1.63146156
33MP0002653_abnormal_ependyma_morphology1.54580861
34MP0003567_abnormal_fetal_cardiomyocyte1.54476667
35MP0010030_abnormal_orbit_morphology1.54036359
36MP0008260_abnormal_autophagy1.51811087
37MP0000537_abnormal_urethra_morphology1.45863331
38MP0000313_abnormal_cell_death1.45334567
39MP0005623_abnormal_meninges_morphology1.44934383
40MP0003121_genomic_imprinting1.43142823
41MP0005501_abnormal_skin_physiology1.42737625
42MP0003806_abnormal_nucleotide_metabolis1.42346847
43MP0005076_abnormal_cell_differentiation1.40738697
44MP0002796_impaired_skin_barrier1.38272820
45MP0003315_abnormal_perineum_morphology1.35636735
46MP0003119_abnormal_digestive_system1.26178249
47MP0009672_abnormal_birth_weight1.25122154
48MP0003221_abnormal_cardiomyocyte_apopto1.25101720
49MP0002019_abnormal_tumor_incidence1.22446520
50MP0009053_abnormal_anal_canal1.21561534
51MP0000358_abnormal_cell_content/1.21518450
52MP0003705_abnormal_hypodermis_morpholog1.21178699
53MP0002210_abnormal_sex_determination1.21063698
54MP0001661_extended_life_span1.19902650
55MP0001293_anophthalmia1.19757615
56MP0002160_abnormal_reproductive_system1.17340756
57MP0004858_abnormal_nervous_system1.16592432
58MP0004272_abnormal_basement_membrane1.16544895
59MP0000490_abnormal_crypts_of1.16066423
60MP0009697_abnormal_copulation1.14286232
61MP0005257_abnormal_intraocular_pressure1.12975419
62MP0003890_abnormal_embryonic-extraembry1.09892879
63MP0001145_abnormal_male_reproductive1.09338060
64MP0004808_abnormal_hematopoietic_stem1.08107937
65MP0000678_abnormal_parathyroid_gland1.03656143
66MP0001346_abnormal_lacrimal_gland1.02723268
67MP0001348_abnormal_lacrimal_gland1.02139926
68MP0008438_abnormal_cutaneous_collagen1.02086803
69MP0005384_cellular_phenotype1.01970718
70MP0000428_abnormal_craniofacial_morphol1.01680167
71MP0004233_abnormal_muscle_weight1.00365012
72MP0000750_abnormal_muscle_regeneration1.00160788
73MP0002697_abnormal_eye_size1.00118449
74MP0002060_abnormal_skin_morphology0.99748577
75MP0009333_abnormal_splenocyte_physiolog0.98744391
76MP0005621_abnormal_cell_physiology0.97635743
77MP0009703_decreased_birth_body0.96836902
78MP0002269_muscular_atrophy0.93571503
79MP0003453_abnormal_keratinocyte_physiol0.93529442
80MP0001929_abnormal_gametogenesis0.93424436
81MP0002111_abnormal_tail_morphology0.90313788
82MP0000653_abnormal_sex_gland0.90174444
83MP0001216_abnormal_epidermal_layer0.90042328
84MP0004084_abnormal_cardiac_muscle0.89983799
85MP0001545_abnormal_hematopoietic_system0.87814830
86MP0005397_hematopoietic_system_phenotyp0.87814830
87MP0001849_ear_inflammation0.87137159
88MP0000579_abnormal_nail_morphology0.87006350
89MP0003385_abnormal_body_wall0.86449441
90MP0009840_abnormal_foam_cell0.86155907
91MP0003937_abnormal_limbs/digits/tail_de0.84847321
92MP0005389_reproductive_system_phenotype0.83198592
93MP0003566_abnormal_cell_adhesion0.80929406
94MP0006035_abnormal_mitochondrial_morpho0.80819415
95MP0003878_abnormal_ear_physiology0.80358739
96MP0005377_hearing/vestibular/ear_phenot0.80358739
97MP0002089_abnormal_postnatal_growth/wei0.79190785
98MP0000751_myopathy0.78712578
99MP0003941_abnormal_skin_development0.77894932
100MP0000762_abnormal_tongue_morphology0.77845267
101MP0005395_other_phenotype0.76625709
102MP0002098_abnormal_vibrissa_morphology0.76605403
103MP0005058_abnormal_lysosome_morphology0.76390094
104MP0005023_abnormal_wound_healing0.75085275
105MP0001881_abnormal_mammary_gland0.74634687
106MP0000003_abnormal_adipose_tissue0.74056327
107MP0000566_synostosis0.73872140
108MP0000377_abnormal_hair_follicle0.72795997
109MP0002092_abnormal_eye_morphology0.69443950
110MP0000703_abnormal_thymus_morphology0.69114047
111MP0000467_abnormal_esophagus_morphology0.68811584
112MP0010630_abnormal_cardiac_muscle0.67846486
113MP0003942_abnormal_urinary_system0.65465898
114MP0001119_abnormal_female_reproductive0.64942426
115MP0004264_abnormal_extraembryonic_tissu0.64832237
116MP0004782_abnormal_surfactant_physiolog0.64624975
117MP0004133_heterotaxia0.64085532
118MP0004087_abnormal_muscle_fiber0.63457933
119MP0000733_abnormal_muscle_development0.62790805
120MP0008770_decreased_survivor_rate0.62784139
121MP0000759_abnormal_skeletal_muscle0.62189105
122MP0000747_muscle_weakness0.57747474
123MP0001915_intracranial_hemorrhage0.57620799
124MP0003861_abnormal_nervous_system0.57565884
125MP0001727_abnormal_embryo_implantation0.55054305
126MP0000627_abnormal_mammary_gland0.55020715
127MP0003699_abnormal_female_reproductive0.54996655
128MP0009278_abnormal_bone_marrow0.54852037
129MP0002161_abnormal_fertility/fecundity0.54711420
130MP0001542_abnormal_bone_strength0.52681163
131MP0005266_abnormal_metabolism0.52310966
132MP0002722_abnormal_immune_system0.52167482
133MP0003115_abnormal_respiratory_system0.50965524
134MP0001286_abnormal_eye_development0.50176381
135MP0003936_abnormal_reproductive_system0.48376247
136MP0003935_abnormal_craniofacial_develop0.48354593
137MP0000477_abnormal_intestine_morphology0.48342238

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.13239722
2Breast hypoplasia (HP:0003187)4.33303841
3Cerebral hypomyelination (HP:0006808)4.15464119
4Ependymoma (HP:0002888)3.98258136
5Carpal bone hypoplasia (HP:0001498)3.90855914
6Abnormality of the anterior horn cell (HP:0006802)3.84793979
7Degeneration of anterior horn cells (HP:0002398)3.84793979
8Abnormality of the labia minora (HP:0012880)3.79905197
9Impulsivity (HP:0100710)3.75684205
10Hyperacusis (HP:0010780)3.72002910
11Selective tooth agenesis (HP:0001592)3.63114033
12Patellar aplasia (HP:0006443)3.60842655
13Rough bone trabeculation (HP:0100670)3.54711897
14Aplasia/Hypoplasia of the patella (HP:0006498)3.52388744
15Abnormal gallbladder physiology (HP:0012438)3.35981807
16Cholecystitis (HP:0001082)3.35981807
17Oral leukoplakia (HP:0002745)3.22411310
18Insomnia (HP:0100785)3.14420381
19Colon cancer (HP:0003003)3.10251455
20Abnormality of glycolysis (HP:0004366)3.05149964
21Medulloblastoma (HP:0002885)2.96242913
22Absent radius (HP:0003974)2.94928048
23Multiple enchondromatosis (HP:0005701)2.91799791
24Chromsome breakage (HP:0040012)2.80040331
25Glioma (HP:0009733)2.77512285
26Aplasia involving forearm bones (HP:0009822)2.74713608
27Absent forearm bone (HP:0003953)2.74713608
28Meckel diverticulum (HP:0002245)2.74671015
29Trismus (HP:0000211)2.74567353
30Chromosomal breakage induced by crosslinking agents (HP:0003221)2.74403102
31Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.73575865
32Abnormality of the umbilical cord (HP:0010881)2.73400951
33Premature ovarian failure (HP:0008209)2.72607965
34Astrocytoma (HP:0009592)2.72415763
35Abnormality of the astrocytes (HP:0100707)2.72415763
36Termporal pattern (HP:0011008)2.70908604
37Insidious onset (HP:0003587)2.70908604
38Microvesicular hepatic steatosis (HP:0001414)2.68078261
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.65759894
40Ureteral duplication (HP:0000073)2.65754934
41Agnosia (HP:0010524)2.64360513
42Cortical dysplasia (HP:0002539)2.60454899
43Rhabdomyosarcoma (HP:0002859)2.59459836
44Abnormality of the ileum (HP:0001549)2.58646325
45Neoplasm of the pancreas (HP:0002894)2.58228160
46Premature rupture of membranes (HP:0001788)2.57474260
47Abnormality of chromosome stability (HP:0003220)2.52535062
48Pelvic girdle muscle weakness (HP:0003749)2.50038266
49Hypoplasia of the capital femoral epiphysis (HP:0003090)2.49827005
50Spastic diplegia (HP:0001264)2.49822055
51Abnormality of the preputium (HP:0100587)2.49360058
52Abnormal trabecular bone morphology (HP:0100671)2.48403990
53CNS hypomyelination (HP:0003429)2.44720056
54Shoulder girdle muscle weakness (HP:0003547)2.41052842
55Increased serum pyruvate (HP:0003542)2.40714783
56Spinal muscular atrophy (HP:0007269)2.39551431
57Progressive muscle weakness (HP:0003323)2.37526894
58Secondary amenorrhea (HP:0000869)2.35183108
59Achilles tendon contracture (HP:0001771)2.34674812
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.32956445
61Proximal placement of thumb (HP:0009623)2.32293301
62Microretrognathia (HP:0000308)2.31928759
63Overriding aorta (HP:0002623)2.31336682
64Absent thumb (HP:0009777)2.31068242
65Ragged-red muscle fibers (HP:0003200)2.28426178
66Progressive external ophthalmoplegia (HP:0000590)2.28233924
67Small intestinal stenosis (HP:0012848)2.24093361
68Duodenal stenosis (HP:0100867)2.24093361
69Horseshoe kidney (HP:0000085)2.23336509
70Deviation of the thumb (HP:0009603)2.22719949
71Megaloblastic anemia (HP:0001889)2.22627053
72Hyperglycinemia (HP:0002154)2.22601796
73Abnormality of the distal phalanges of the toes (HP:0010182)2.21741915
74Orthostatic hypotension (HP:0001278)2.20923666
75Reticulocytopenia (HP:0001896)2.19507615
76Upper limb muscle weakness (HP:0003484)2.19480272
77Premature graying of hair (HP:0002216)2.19260347
78Abnormality of oral frenula (HP:0000190)2.15640295
79Distal lower limb amyotrophy (HP:0008944)2.14248017
80Ankyloglossia (HP:0010296)2.14014643
81Aplasia/hypoplasia of the humerus (HP:0006507)2.13556273
82Atresia of the external auditory canal (HP:0000413)2.13028757
83Abnormality of the lower motor neuron (HP:0002366)2.12827731
84Bone marrow hypocellularity (HP:0005528)2.11598889
85Tongue fasciculations (HP:0001308)2.10930081
86Increased nuchal translucency (HP:0010880)2.10280547
87Short nail (HP:0001799)2.06805342
88Elfin facies (HP:0004428)2.06723808
89Abnormal number of incisors (HP:0011064)2.06226758
90Postnatal microcephaly (HP:0005484)2.05632820
91Muscle fibrillation (HP:0010546)2.05179193
92High anterior hairline (HP:0009890)2.04317118
93Entropion (HP:0000621)2.04294345
94Sloping forehead (HP:0000340)2.03685484
95Back pain (HP:0003418)2.03541357
96Cafe-au-lait spot (HP:0000957)2.03327511
97Ulnar bowing (HP:0003031)2.02416888
98Myelodysplasia (HP:0002863)2.01892684
99Personality changes (HP:0000751)2.01496768
100Long palpebral fissure (HP:0000637)2.01390416
101Abnormality of the hip-girdle musculature (HP:0001445)2.00611643
102Abnormality of the musculature of the pelvis (HP:0001469)2.00611643
103Basal cell carcinoma (HP:0002671)1.99385103
104Broad distal phalanx of finger (HP:0009836)1.98171892
105Prominent nose (HP:0000448)1.98145120
106Tracheoesophageal fistula (HP:0002575)1.96735213
107Abnormality of the Achilles tendon (HP:0005109)1.96330761
108Slender long bone (HP:0003100)1.95866670
109Cellular immunodeficiency (HP:0005374)1.95361729
110Upper limb amyotrophy (HP:0009129)1.94588488
111Distal upper limb amyotrophy (HP:0007149)1.94588488
112Breast aplasia (HP:0100783)1.93076042
113Asymmetry of the thorax (HP:0001555)1.92544411
114Abnormality of the calcaneus (HP:0008364)1.91290449
115Vertebral compression fractures (HP:0002953)1.90791844
116Increased connective tissue (HP:0009025)1.90212485
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.89970227
118Glossoptosis (HP:0000162)1.88742327
119Neoplasm of striated muscle (HP:0009728)1.88523202
120Abnormal neuron morphology (HP:0012757)1.88501677
121Abnormality of the motor neurons (HP:0002450)1.88501677
122Abnormality of cells of the erythroid lineage (HP:0012130)1.88492241
123Reticulocytosis (HP:0001923)1.88296443
124Renal duplication (HP:0000075)1.88229112
125Facial hemangioma (HP:0000329)1.87528219
126Lower limb amyotrophy (HP:0007210)1.85416841
127Aplastic anemia (HP:0001915)1.83412582
128Squamous cell carcinoma (HP:0002860)1.83141834
129Abnormal number of erythroid precursors (HP:0012131)1.82185312
130Unilateral renal agenesis (HP:0000122)1.81329156
131Abnormalities of placenta or umbilical cord (HP:0001194)1.81087579
132Supernumerary spleens (HP:0009799)1.80853296
133Patellar dislocation (HP:0002999)1.80357026
134Septate vagina (HP:0001153)1.80325122
135Sparse lateral eyebrow (HP:0005338)1.80008805
136Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79313566
137Abnormality of the duodenum (HP:0002246)1.79240043
138Aplasia/Hypoplasia of the sternum (HP:0006714)1.78262430
139Angiofibromas (HP:0010615)1.77324482
140Adenoma sebaceum (HP:0009720)1.77324482
141Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77317607
142Absent epiphyses (HP:0010577)1.77317607
143Progressive hearing impairment (HP:0001730)1.76560411
144Aplasia/Hypoplasia of the breasts (HP:0010311)1.76116115
145Deep philtrum (HP:0002002)1.75750561
146Cholelithiasis (HP:0001081)1.75649221
147Overlapping toe (HP:0001845)1.75559337
148Cleft eyelid (HP:0000625)1.75379192
149Abnormal umbilical cord blood vessels (HP:0011403)1.74905405
150Single umbilical artery (HP:0001195)1.74905405
151Abnormality of the fetal cardiovascular system (HP:0010948)1.74905405
152Hand muscle atrophy (HP:0009130)1.74446618
153Impaired pain sensation (HP:0007328)1.73580326
154Abnormality of pain sensation (HP:0010832)1.73580326
155Nephroblastoma (Wilms tumor) (HP:0002667)1.73199645
156Osteolytic defects of the hand bones (HP:0009699)1.73019582
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.73019582
158Missing ribs (HP:0000921)1.71528963
159Microglossia (HP:0000171)1.69669957
160Dysmetric saccades (HP:0000641)1.67887728
161Pointed chin (HP:0000307)1.67296721
162Abnormality of reticulocytes (HP:0004312)1.66125501
163Spinal rigidity (HP:0003306)1.65496579
164Facial cleft (HP:0002006)1.63035775
165Poikiloderma (HP:0001029)1.61930586
166Hypokinesia (HP:0002375)1.61537053
167Broad face (HP:0000283)1.60368876
168Urethral obstruction (HP:0000796)1.59698456
169Fasciculations (HP:0002380)1.58476974
170Testicular atrophy (HP:0000029)1.57984791
171Embryonal renal neoplasm (HP:0011794)1.57228423
172Choanal atresia (HP:0000453)1.56355466
173Natal tooth (HP:0000695)1.56223458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.38686586
2WEE14.85677716
3TSSK64.53973706
4SMG13.32684530
5CDC73.27351402
6NEK13.19187954
7EIF2AK13.01696450
8NEK22.76265192
9TTK2.53547473
10EPHA22.46079459
11PBK2.45285088
12PLK42.39981989
13IRAK32.23350464
14PNCK2.17436133
15ICK2.15718565
16PLK12.06671202
17SRPK12.03859538
18VRK21.99696962
19BRSK21.98794772
20PLK31.96908708
21TESK21.80337745
22ACVR1B1.77471098
23MST1R1.74698411
24BRSK11.66104534
25STK161.63265914
26EEF2K1.55206455
27EIF2AK31.54451321
28CDK121.48832835
29MKNK11.47542598
30AKT31.47325376
31AURKB1.47021163
32PDK31.40602324
33PDK41.40602324
34ALK1.40045494
35CCNB11.39290912
36ATR1.39025779
37CDK71.34387502
38PASK1.31163986
39RPS6KB21.30670735
40AURKA1.29310525
41CHEK21.29220669
42MAP3K81.27416740
43MKNK21.27383282
44CHEK11.24601336
45ZAK1.24481246
46CDK41.18442319
47LATS21.15847985
48DYRK31.14830372
49NME21.13489898
50PAK41.09005133
51SCYL21.07655162
52SIK10.98842906
53CLK10.94667710
54ERBB40.91149380
55CDK20.88721487
56RPS6KA40.87833210
57PDGFRA0.87184193
58PRPF4B0.86519437
59MET0.86337590
60BRAF0.86145683
61KSR20.85765247
62STK100.85430184
63MAP3K90.84588503
64TLK10.81769035
65VRK10.80183964
66PRKCI0.79745969
67STK38L0.79098707
68PAK10.77805432
69TAF10.77439555
70PDK20.76334681
71PTK20.75307886
72FGFR40.74943307
73PKN20.73817378
74STK30.70945031
75CAMK1D0.70308621
76ATM0.69693065
77PIM20.68743264
78BRD40.65756113
79MTOR0.64843780
80CSNK2A20.63432209
81CSNK1E0.63024896
82CDK180.62696333
83* CDK10.61289164
84TGFBR10.58963847
85CDK90.58423696
86PIM10.56798015
87TESK10.56234582
88KSR10.54726543
89TRIB30.53230507
90MST40.52093214
91LMTK20.51679668
92NTRK10.51484649
93STK40.50649432
94* CSNK2A10.49526044
95MAP3K110.49332533
96PRKD30.48160718
97MAPKAPK30.46436612
98MELK0.46309202
99ARAF0.42938165
100MAPKAPK50.42799921
101SIK30.42692765
102AKT20.42600146
103LRRK20.40562764
104MAPK110.39678359
105BMX0.39365037
106MAP3K100.38829750
107TAOK20.37551383
108FGFR10.37129499
109CAMK1G0.36849292
110CDK60.36748875
111CSNK1A1L0.36276514
112PTK60.34985962
113PRKDC0.31090320
114EIF2AK20.30624784
115NME10.29270498
116DAPK10.26574358
117FLT30.26492451
118TAOK10.25951293
119PAK20.25728448
120LIMK10.22576048
121RAF10.20986100
122TTN0.20560277
123MAPK140.20033663
124KDR0.19593072
125CDK80.19274961
126CDK11A0.17761493
127MAP3K30.17572173
128CDK140.17446576
129CDK150.16869984
130GSK3B0.16821408
131ILK0.16095139
132MAP3K50.16062292

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44456901
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.34184760
3Mismatch repair_Homo sapiens_hsa034303.88095689
4Proteasome_Homo sapiens_hsa030503.79999277
5RNA transport_Homo sapiens_hsa030133.72184338
6RNA polymerase_Homo sapiens_hsa030203.51303878
7Spliceosome_Homo sapiens_hsa030403.34777568
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.95672585
9Cell cycle_Homo sapiens_hsa041102.88881298
10Base excision repair_Homo sapiens_hsa034102.73682672
11Vitamin B6 metabolism_Homo sapiens_hsa007502.73054504
12Nucleotide excision repair_Homo sapiens_hsa034202.67869486
13One carbon pool by folate_Homo sapiens_hsa006702.62159610
14Homologous recombination_Homo sapiens_hsa034402.52778359
15Pyrimidine metabolism_Homo sapiens_hsa002402.36220682
16Ribosome_Homo sapiens_hsa030102.14298438
17Fanconi anemia pathway_Homo sapiens_hsa034601.81944064
18mRNA surveillance pathway_Homo sapiens_hsa030151.78793486
19Basal transcription factors_Homo sapiens_hsa030221.75895058
20p53 signaling pathway_Homo sapiens_hsa041151.68726765
21RNA degradation_Homo sapiens_hsa030181.65436308
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.55732307
23Biosynthesis of amino acids_Homo sapiens_hsa012301.50861452
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.45646844
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40665379
26Oocyte meiosis_Homo sapiens_hsa041141.39103267
27Epstein-Barr virus infection_Homo sapiens_hsa051691.38718589
28Non-homologous end-joining_Homo sapiens_hsa034501.38551062
29Pentose phosphate pathway_Homo sapiens_hsa000301.34562584
30Purine metabolism_Homo sapiens_hsa002301.34477996
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31887511
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22072229
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22028418
34Folate biosynthesis_Homo sapiens_hsa007901.08127834
35Steroid biosynthesis_Homo sapiens_hsa001001.07912006
36Carbon metabolism_Homo sapiens_hsa012001.03903293
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03507570
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97314708
39Viral carcinogenesis_Homo sapiens_hsa052030.92597235
40Antigen processing and presentation_Homo sapiens_hsa046120.92099403
41Fructose and mannose metabolism_Homo sapiens_hsa000510.91885967
42Regulation of autophagy_Homo sapiens_hsa041400.91652156
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91524462
44Selenocompound metabolism_Homo sapiens_hsa004500.89051780
45Vibrio cholerae infection_Homo sapiens_hsa051100.87862580
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.82703968
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.82591947
48Lysine degradation_Homo sapiens_hsa003100.80198722
49Non-small cell lung cancer_Homo sapiens_hsa052230.80100723
50Pancreatic cancer_Homo sapiens_hsa052120.78130644
51Fatty acid elongation_Homo sapiens_hsa000620.76175175
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74883150
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73132665
54Systemic lupus erythematosus_Homo sapiens_hsa053220.70246787
55mTOR signaling pathway_Homo sapiens_hsa041500.63934281
56HTLV-I infection_Homo sapiens_hsa051660.63553747
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62403663
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60494910
59Hippo signaling pathway_Homo sapiens_hsa043900.57460798
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56683018
61Proteoglycans in cancer_Homo sapiens_hsa052050.54180946
62Thyroid cancer_Homo sapiens_hsa052160.53956502
63Herpes simplex infection_Homo sapiens_hsa051680.52760624
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51853901
65Glioma_Homo sapiens_hsa052140.51314687
66Fatty acid biosynthesis_Homo sapiens_hsa000610.49885031
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49593729
68MicroRNAs in cancer_Homo sapiens_hsa052060.48188427
69Legionellosis_Homo sapiens_hsa051340.47836582
70Sulfur relay system_Homo sapiens_hsa041220.46408058
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46290333
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.43132620
73Small cell lung cancer_Homo sapiens_hsa052220.42684454
74ErbB signaling pathway_Homo sapiens_hsa040120.42583826
75Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42544568
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.41811642
77Fatty acid metabolism_Homo sapiens_hsa012120.41304876
78HIF-1 signaling pathway_Homo sapiens_hsa040660.40639916
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39513936
80Arginine biosynthesis_Homo sapiens_hsa002200.39189056
81Renal cell carcinoma_Homo sapiens_hsa052110.35010217
82Galactose metabolism_Homo sapiens_hsa000520.34125492
83Glutathione metabolism_Homo sapiens_hsa004800.33742290
84Colorectal cancer_Homo sapiens_hsa052100.33154963
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.32630987
86VEGF signaling pathway_Homo sapiens_hsa043700.29084262
87Bladder cancer_Homo sapiens_hsa052190.27976261
88Apoptosis_Homo sapiens_hsa042100.27757196
89Tight junction_Homo sapiens_hsa045300.26068516
90Hedgehog signaling pathway_Homo sapiens_hsa043400.25193778
91Wnt signaling pathway_Homo sapiens_hsa043100.24152814
92TGF-beta signaling pathway_Homo sapiens_hsa043500.20214097
93Basal cell carcinoma_Homo sapiens_hsa052170.19962763
94Vitamin digestion and absorption_Homo sapiens_hsa049770.19785236
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18161184
96Metabolic pathways_Homo sapiens_hsa011000.16589017
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16234743
98Alcoholism_Homo sapiens_hsa050340.16136629
99Notch signaling pathway_Homo sapiens_hsa043300.15930672
100Renin-angiotensin system_Homo sapiens_hsa046140.15598752
101Arginine and proline metabolism_Homo sapiens_hsa003300.15574790
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15393142
103Adherens junction_Homo sapiens_hsa045200.15133565
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14495403
105FoxO signaling pathway_Homo sapiens_hsa040680.14490068
106Chronic myeloid leukemia_Homo sapiens_hsa052200.13207772
107Huntingtons disease_Homo sapiens_hsa050160.12760813
108Shigellosis_Homo sapiens_hsa051310.12197876
109Pathways in cancer_Homo sapiens_hsa052000.11703733
110Pyruvate metabolism_Homo sapiens_hsa006200.10055987
111Prostate cancer_Homo sapiens_hsa052150.09779252
112AMPK signaling pathway_Homo sapiens_hsa041520.08942487
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.08384465
114Hepatitis B_Homo sapiens_hsa051610.07360215
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.07156901
116N-Glycan biosynthesis_Homo sapiens_hsa005100.05838201
117Acute myeloid leukemia_Homo sapiens_hsa052210.05369486
118Endometrial cancer_Homo sapiens_hsa052130.03964153
119Insulin signaling pathway_Homo sapiens_hsa049100.03077026

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