STIP1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.89834088
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.10417701
3protein-cofactor linkage (GO:0018065)4.82217203
4tolerance induction (GO:0002507)4.76458781
5establishment of protein localization to mitochondrial membrane (GO:0090151)4.73916878
6cellular response to interleukin-15 (GO:0071350)4.72845002
7cytidine metabolic process (GO:0046087)4.66985293
8cytidine catabolic process (GO:0006216)4.66985293
9cytidine deamination (GO:0009972)4.66985293
10positive regulation of mitochondrial fission (GO:0090141)4.66241591
11ATP synthesis coupled proton transport (GO:0015986)4.54500404
12energy coupled proton transport, down electrochemical gradient (GO:0015985)4.54500404
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.52282198
14chaperone-mediated protein transport (GO:0072321)4.50559496
15peptidyl-arginine omega-N-methylation (GO:0035247)4.42998265
16rRNA methylation (GO:0031167)4.34972292
17protein neddylation (GO:0045116)4.34119322
18rRNA modification (GO:0000154)4.30483277
19cellular response to exogenous dsRNA (GO:0071360)4.04442442
20negative regulation of telomere maintenance (GO:0032205)4.04320923
21negative regulation of synaptic transmission, GABAergic (GO:0032229)4.01095876
22pyrimidine ribonucleoside catabolic process (GO:0046133)3.99490182
23proteasome assembly (GO:0043248)3.93769558
24nucleotide-excision repair, DNA damage removal (GO:0000718)3.88917274
25DNA excision (GO:0044349)3.88917274
26negative regulation by host of viral transcription (GO:0043922)3.84371380
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72465066
28peptidyl-arginine methylation (GO:0018216)3.65428343
29peptidyl-arginine N-methylation (GO:0035246)3.65428343
30exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58841556
31response to interleukin-15 (GO:0070672)3.53803350
32regulation of mitochondrial translation (GO:0070129)3.52740992
33somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.47243254
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.47243254
35isotype switching (GO:0045190)3.47243254
36mannosylation (GO:0097502)3.42256524
37protein complex biogenesis (GO:0070271)3.41258452
38iron-sulfur cluster assembly (GO:0016226)3.30604939
39metallo-sulfur cluster assembly (GO:0031163)3.30604939
40regulation of mitochondrial fission (GO:0090140)3.27893529
41histone arginine methylation (GO:0034969)3.26993472
42negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25035662
43pseudouridine synthesis (GO:0001522)3.22748444
44regulation of T cell receptor signaling pathway (GO:0050856)3.21463966
45inner mitochondrial membrane organization (GO:0007007)3.16768586
46negative regulation of heart rate (GO:0010459)3.16301877
47protein deneddylation (GO:0000338)3.14250277
48positive regulation of uterine smooth muscle contraction (GO:0070474)3.14170050
49regulation of defense response to virus by host (GO:0050691)3.10734737
50regulation of cellular amino acid metabolic process (GO:0006521)3.10314558
51transcription elongation from RNA polymerase III promoter (GO:0006385)3.06495913
52termination of RNA polymerase III transcription (GO:0006386)3.06495913
53DNA damage response, detection of DNA damage (GO:0042769)3.04515355
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03286109
55positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00644116
56mast cell activation involved in immune response (GO:0002279)2.99697438
57mast cell degranulation (GO:0043303)2.99697438
58signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98824244
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98824244
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98824244
61mitochondrial respiratory chain complex assembly (GO:0033108)2.98031004
62intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96533227
63signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96533227
64RNA destabilization (GO:0050779)2.94761726
65RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90542457
66tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90542457
67ribosomal small subunit assembly (GO:0000028)2.90313648
68respiratory electron transport chain (GO:0022904)2.89881859
69cellular response to dsRNA (GO:0071359)2.89809933
70signal transduction involved in DNA damage checkpoint (GO:0072422)2.89179092
71signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89179092
72positive regulation of prostaglandin secretion (GO:0032308)2.88830661
737-methylguanosine mRNA capping (GO:0006370)2.87975607
74mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87213430
75transcription elongation from RNA polymerase I promoter (GO:0006362)2.86734423
76electron transport chain (GO:0022900)2.86069713
77signal transduction involved in cell cycle checkpoint (GO:0072395)2.85447826
78negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.82430657
79negative regulation of ligase activity (GO:0051352)2.82430657
80regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.82205289
817-methylguanosine RNA capping (GO:0009452)2.80585630
82RNA capping (GO:0036260)2.80585630
83DNA ligation (GO:0006266)2.77467612
84platelet dense granule organization (GO:0060155)2.77461337
85lysosome localization (GO:0032418)2.76811988
86ATP biosynthetic process (GO:0006754)2.73962708
87respiratory chain complex IV assembly (GO:0008535)2.71968934
88ribosomal large subunit biogenesis (GO:0042273)2.71866613
89somatic diversification of immunoglobulins (GO:0016445)2.70907999
90regulation of chronic inflammatory response (GO:0002676)2.70628741
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.70360782
92regulation of gamma-delta T cell differentiation (GO:0045586)2.69922288
93monocyte chemotaxis (GO:0002548)2.69716192
94transcription from RNA polymerase I promoter (GO:0006360)2.69297833
95negative regulation of amino acid transport (GO:0051956)2.67983516
96termination of RNA polymerase I transcription (GO:0006363)2.67032036
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.62294484
98transcription-coupled nucleotide-excision repair (GO:0006283)2.61842323
99purine nucleoside triphosphate biosynthetic process (GO:0009145)2.60441895
100cullin deneddylation (GO:0010388)2.58918830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.92299162
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.83143931
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.79622756
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.93693741
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.75242509
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24755498
7ELK1_19687146_ChIP-ChIP_HELA_Human3.05275911
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99863078
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92549802
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.73218736
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72147319
12VDR_23849224_ChIP-Seq_CD4+_Human2.67235640
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.43588102
14FOXP3_21729870_ChIP-Seq_TREG_Human2.43290759
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37865226
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35483885
17GATA1_22025678_ChIP-Seq_K562_Human2.32996908
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.32915154
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28070655
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.17569980
21VDR_22108803_ChIP-Seq_LS180_Human2.16914946
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.14884417
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10030531
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08601516
25MYC_18940864_ChIP-ChIP_HL60_Human1.99505838
26PADI4_21655091_ChIP-ChIP_MCF-7_Human1.99384801
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.93970910
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.82608107
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76162290
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75255860
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74771178
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73494889
33ZNF274_21170338_ChIP-Seq_K562_Hela1.59930565
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59334977
35DCP1A_22483619_ChIP-Seq_HELA_Human1.57916281
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57077948
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50835553
38IRF1_19129219_ChIP-ChIP_H3396_Human1.50602460
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48532313
40ELK1_22589737_ChIP-Seq_MCF10A_Human1.47380293
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45514826
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42270693
43GABP_19822575_ChIP-Seq_HepG2_Human1.41279133
44KDM5A_27292631_Chip-Seq_BREAST_Human1.40995409
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38640565
46BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.38289844
47CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35292671
48TTF2_22483619_ChIP-Seq_HELA_Human1.34672451
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34469733
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.34314381
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33185328
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31797561
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.31435028
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31175971
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31117791
56XRN2_22483619_ChIP-Seq_HELA_Human1.25608600
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24465485
58TAF15_26573619_Chip-Seq_HEK293_Human1.23467524
59AR_20517297_ChIP-Seq_VCAP_Human1.22340974
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21528562
61CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.18525967
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.15752395
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14780292
64ERG_20517297_ChIP-Seq_VCAP_Human1.13292225
65MYB_26560356_Chip-Seq_TH2_Human1.13287063
66IGF1R_20145208_ChIP-Seq_DFB_Human1.13208687
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12604576
68GATA3_26560356_Chip-Seq_TH2_Human1.11372588
69TP53_22573176_ChIP-Seq_HFKS_Human1.10792500
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10697882
71EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09419123
72MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.08559112
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08524091
74FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07804471
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06704636
76FOXA1_25329375_ChIP-Seq_VCAP_Human1.05028271
77FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05028271
78FUS_26573619_Chip-Seq_HEK293_Human1.03356461
79TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02850955
80EWS_26573619_Chip-Seq_HEK293_Human1.00581122
81NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00351946
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99366698
83STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94868765
84TDRD3_21172665_ChIP-Seq_MCF-7_Human0.94460833
85HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94409496
86TAF2_19829295_ChIP-Seq_ESCs_Human0.92693551
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91251212
88PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91080582
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89993069
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.89220077
91MYC_19079543_ChIP-ChIP_MESCs_Mouse0.88563683
92TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88330773
93SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87648949
94NANOG_19829295_ChIP-Seq_ESCs_Human0.87348772
95SOX2_19829295_ChIP-Seq_ESCs_Human0.87348772
96GATA6_21074721_ChIP-Seq_CACO-2_Human0.87065186
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86988063
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.86195252
99TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86177615
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.84366269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.56328063
2MP0005671_abnormal_response_to3.40979291
3MP0008058_abnormal_DNA_repair3.10006152
4MP0008007_abnormal_cellular_replicative2.81348606
5MP0002254_reproductive_system_inflammat2.63584767
6MP0004133_heterotaxia2.61053287
7MP0008875_abnormal_xenobiotic_pharmacok2.60137413
8MP0002166_altered_tumor_susceptibility2.37645585
9MP0002277_abnormal_respiratory_mucosa2.33395186
10MP0006072_abnormal_retinal_apoptosis2.26810535
11MP0002006_tumorigenesis2.26648957
12MP0002102_abnormal_ear_morphology2.22566450
13MP0003763_abnormal_thymus_physiology2.21781708
14MP0006035_abnormal_mitochondrial_morpho2.10315188
15MP0002138_abnormal_hepatobiliary_system2.08887118
16MP0005646_abnormal_pituitary_gland1.92568392
17MP0006036_abnormal_mitochondrial_physio1.90296813
18MP0005075_abnormal_melanosome_morpholog1.88746014
19MP0004147_increased_porphyrin_level1.88702771
20MP0002148_abnormal_hypersensitivity_rea1.83166297
21MP0001919_abnormal_reproductive_system1.82463613
22MP0005410_abnormal_fertilization1.79546882
23MP0001529_abnormal_vocalization1.73195497
24MP0003786_premature_aging1.72632442
25MP0008789_abnormal_olfactory_epithelium1.71317955
26MP0003111_abnormal_nucleus_morphology1.67454914
27MP0005000_abnormal_immune_tolerance1.66803086
28MP0003136_yellow_coat_color1.63649778
29MP0002653_abnormal_ependyma_morphology1.58994921
30MP0002822_catalepsy1.58558216
31MP0006292_abnormal_olfactory_placode1.57691624
32MP0002009_preneoplasia1.54941335
33MP0005167_abnormal_blood-brain_barrier1.54922597
34MP0010094_abnormal_chromosome_stability1.52511385
35MP0001800_abnormal_humoral_immune1.51170728
36MP0001986_abnormal_taste_sensitivity1.49518634
37MP0008872_abnormal_physiological_respon1.44637614
38MP0005551_abnormal_eye_electrophysiolog1.44522509
39MP0002723_abnormal_immune_serum1.41382497
40MP0003252_abnormal_bile_duct1.36051429
41MP0001835_abnormal_antigen_presentation1.33665129
42MP0001905_abnormal_dopamine_level1.32024908
43MP0009333_abnormal_splenocyte_physiolog1.29912148
44MP0001853_heart_inflammation1.28727895
45MP0005389_reproductive_system_phenotype1.27144688
46MP0003011_delayed_dark_adaptation1.26845318
47MP0004043_abnormal_pH_regulation1.25927075
48MP0004142_abnormal_muscle_tone1.24937155
49MP0001984_abnormal_olfaction1.21461821
50MP0004742_abnormal_vestibular_system1.19558306
51MP0003718_maternal_effect1.14909996
52MP0005394_taste/olfaction_phenotype1.14776269
53MP0005499_abnormal_olfactory_system1.14776269
54MP0001790_abnormal_immune_system1.12815578
55MP0005387_immune_system_phenotype1.12815578
56MP0002928_abnormal_bile_duct1.12677486
57MP0001819_abnormal_immune_cell1.12195823
58MP0002452_abnormal_antigen_presenting1.11019711
59MP0002420_abnormal_adaptive_immunity1.09808922
60MP0002837_dystrophic_cardiac_calcinosis1.05445417
61MP0003866_abnormal_defecation1.05420831
62MP0000569_abnormal_digit_pigmentation1.05199889
63MP0000703_abnormal_thymus_morphology1.03568643
64MP0008932_abnormal_embryonic_tissue1.02565393
65MP0005253_abnormal_eye_physiology1.02125030
66MP0003806_abnormal_nucleotide_metabolis1.01782292
67MP0003724_increased_susceptibility_to1.01422353
68MP0009785_altered_susceptibility_to1.01106875
69MP0005084_abnormal_gallbladder_morpholo1.00463776
70MP0002933_joint_inflammation0.99633275
71MP0001968_abnormal_touch/_nociception0.97284157
72MP0004145_abnormal_muscle_electrophysio0.96727205
73MP0002722_abnormal_immune_system0.96133677
74MP0002938_white_spotting0.94745956
75MP0000685_abnormal_immune_system0.94042837
76MP0000358_abnormal_cell_content/0.93451582
77MP0001485_abnormal_pinna_reflex0.91828144
78MP0000689_abnormal_spleen_morphology0.91276802
79MP0003693_abnormal_embryo_hatching0.91128301
80MP0003880_abnormal_central_pattern0.89364655
81MP0001764_abnormal_homeostasis0.88140314
82MP0001188_hyperpigmentation0.87451186
83MP0006082_CNS_inflammation0.85781988
84MP0009764_decreased_sensitivity_to0.84465696
85MP0000631_abnormal_neuroendocrine_gland0.84239390
86MP0005025_abnormal_response_to0.82125414
87MP0001293_anophthalmia0.81121123
88MP0004957_abnormal_blastocyst_morpholog0.80108899
89MP0000427_abnormal_hair_cycle0.79464664
90MP0002160_abnormal_reproductive_system0.79087301
91MP0002272_abnormal_nervous_system0.76588486
92MP0000716_abnormal_immune_system0.76252012
93MP0005085_abnormal_gallbladder_physiolo0.75463799
94MP0000372_irregular_coat_pigmentation0.75402956
95MP0010155_abnormal_intestine_physiology0.75198739
96MP0002736_abnormal_nociception_after0.74477787
97MP0003567_abnormal_fetal_cardiomyocyte0.74193629
98MP0001929_abnormal_gametogenesis0.73669137
99MP0003638_abnormal_response/metabolism_0.73003344
100MP0002398_abnormal_bone_marrow0.70414873

Predicted human phenotypes

RankGene SetZ-score
1Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.45545962
2Decreased activity of mitochondrial respiratory chain (HP:0008972)4.45545962
3IgG deficiency (HP:0004315)4.08253674
4Increased intramyocellular lipid droplets (HP:0012240)3.96874071
5Abnormal mitochondria in muscle tissue (HP:0008316)3.73111277
6IgM deficiency (HP:0002850)3.42134038
7Bilateral microphthalmos (HP:0007633)3.35561815
8Increased CSF lactate (HP:0002490)3.28353761
9Anterior segment dysgenesis (HP:0007700)3.25827048
10Mitochondrial inheritance (HP:0001427)3.24361895
11Increased muscle lipid content (HP:0009058)3.20357980
12Acute necrotizing encephalopathy (HP:0006965)3.08381734
13Abnormality of B cell number (HP:0010975)3.05660531
14Increased hepatocellular lipid droplets (HP:0006565)3.04845684
15Dyschromatopsia (HP:0007641)3.03582518
16Abnormality of the prostate (HP:0008775)3.02888567
17Oligodactyly (hands) (HP:0001180)3.01829921
18Hepatocellular necrosis (HP:0001404)3.01533398
19Severe combined immunodeficiency (HP:0004430)2.91414570
20Nephronophthisis (HP:0000090)2.91241903
21Abolished electroretinogram (ERG) (HP:0000550)2.85186880
22Retinal dysplasia (HP:0007973)2.79079939
23Stomatitis (HP:0010280)2.78900260
24Type II lissencephaly (HP:0007260)2.77510226
25Acute encephalopathy (HP:0006846)2.75512880
26Tubulointerstitial nephritis (HP:0001970)2.70729198
27Abnormality of the renal medulla (HP:0100957)2.66487285
28Chorioretinal atrophy (HP:0000533)2.62386041
29B lymphocytopenia (HP:0010976)2.60921273
30Medial flaring of the eyebrow (HP:0010747)2.59964349
31Lipid accumulation in hepatocytes (HP:0006561)2.58200893
32Hepatic necrosis (HP:0002605)2.57336925
33Supernumerary spleens (HP:0009799)2.51520084
34Prostate neoplasm (HP:0100787)2.47138304
35Methylmalonic aciduria (HP:0012120)2.45886771
36Increased serum lactate (HP:0002151)2.45316765
37Pancreatic cysts (HP:0001737)2.43252587
38Renal cortical cysts (HP:0000803)2.39590710
39Progressive macrocephaly (HP:0004481)2.39447573
40Optic disc pallor (HP:0000543)2.38552175
413-Methylglutaconic aciduria (HP:0003535)2.37294944
42Lactic acidosis (HP:0003128)2.35442770
43Combined immunodeficiency (HP:0005387)2.31387300
44Increased serum pyruvate (HP:0003542)2.31006524
45Type I transferrin isoform profile (HP:0003642)2.29225261
46Abnormality of the renal cortex (HP:0011035)2.26674010
47Methylmalonic acidemia (HP:0002912)2.21603236
48Cerebellar dysplasia (HP:0007033)2.19875044
49Abnormality of T cells (HP:0002843)2.17568773
50Oral leukoplakia (HP:0002745)2.16655715
51CNS hypomyelination (HP:0003429)2.16418786
52Posterior subcapsular cataract (HP:0007787)2.15748492
53Severe muscular hypotonia (HP:0006829)2.14713205
54Congenital stationary night blindness (HP:0007642)2.12142689
55Brittle hair (HP:0002299)2.11670267
56Cerebral edema (HP:0002181)2.06823675
57Abnormality of T cell physiology (HP:0011840)2.06755844
58Thyroiditis (HP:0100646)2.06683226
59Neuroendocrine neoplasm (HP:0100634)2.06660114
60Oligodactyly (HP:0012165)2.05296593
61Autoimmune thrombocytopenia (HP:0001973)2.02607809
62Aplasia/hypoplasia of the uterus (HP:0008684)2.02385888
63Meckel diverticulum (HP:0002245)2.02295018
64Abnormal number of erythroid precursors (HP:0012131)2.02084213
65Parakeratosis (HP:0001036)2.01909493
66Pendular nystagmus (HP:0012043)2.01795727
67Abnormality of T cell number (HP:0011839)2.01560125
68Inability to walk (HP:0002540)1.97341170
69Abnormality of the ileum (HP:0001549)1.96271945
70Central scotoma (HP:0000603)1.95562868
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.95327973
72Abnormal protein N-linked glycosylation (HP:0012347)1.95327973
73Abnormal protein glycosylation (HP:0012346)1.95327973
74Abnormal glycosylation (HP:0012345)1.95327973
75Exertional dyspnea (HP:0002875)1.94594990
76Nephrogenic diabetes insipidus (HP:0009806)1.92680725
77Fibular aplasia (HP:0002990)1.90545295
78Renal Fanconi syndrome (HP:0001994)1.88358228
79Lethargy (HP:0001254)1.87080675
80Bile duct proliferation (HP:0001408)1.86292347
81Abnormal biliary tract physiology (HP:0012439)1.86292347
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.85512788
83Attenuation of retinal blood vessels (HP:0007843)1.84486714
84Hyperglycinuria (HP:0003108)1.82972720
85Respiratory failure (HP:0002878)1.82334084
86Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82272124
87Abnormality of alanine metabolism (HP:0010916)1.81364843
88Hyperalaninemia (HP:0003348)1.81364843
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81364843
90Exercise intolerance (HP:0003546)1.81310570
91Abnormal spermatogenesis (HP:0008669)1.81282799
92Pulmonary fibrosis (HP:0002206)1.80476998
93True hermaphroditism (HP:0010459)1.80155087
94Abnormality of eosinophils (HP:0001879)1.79472404
95T lymphocytopenia (HP:0005403)1.79077854
96Aplasia/Hypoplasia of the uvula (HP:0010293)1.78275765
97Abnormality of the pons (HP:0007361)1.75092894
98Abnormality of glycolysis (HP:0004366)1.74856153
99Molar tooth sign on MRI (HP:0002419)1.71724370
100Abnormality of midbrain morphology (HP:0002418)1.71724370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.15624379
2TSSK64.61755087
3TLK13.30214567
4VRK22.95358886
5ZAK2.78747105
6BUB12.58551253
7NUAK12.47006322
8VRK12.44862461
9MAPKAPK32.32658301
10BCKDK2.30823179
11MAP2K22.17713378
12TAOK32.17483599
13MAPK152.06624295
14IKBKE2.00278594
15CSNK1G11.59296644
16DAPK11.58017226
17IKBKB1.53408544
18MAP3K131.48813870
19CSNK1G31.46438978
20TBK11.46170051
21WNK31.45554072
22CSNK1A1L1.44831806
23TAF11.40051436
24MKNK11.36131584
25PRKCI1.23495861
26MAP3K141.23192374
27GRK11.18322953
28BCR1.17467112
29ADRBK21.14070542
30CSNK1G21.13822134
31PRKCQ1.10621234
32PLK31.10276306
33MAPKAPK51.09633481
34EIF2AK21.09030599
35PDK21.06684494
36KDR1.03945163
37STK161.01682085
38KIT0.94138808
39EIF2AK10.89535682
40NTRK30.89125593
41MKNK20.88452609
42PINK10.86853426
43CLK10.86528324
44EPHA40.84064237
45BRSK20.82227999
46RPS6KA50.81683727
47DYRK20.80587124
48BMPR20.78145107
49SRPK10.77346407
50SYK0.76144375
51MAP3K90.76080057
52PIM20.76059000
53MAP4K20.75868684
54LCK0.74279787
55WNK40.70925736
56DAPK30.70778191
57PHKG20.69695740
58PHKG10.69695740
59TIE10.69637989
60WEE10.68178241
61AURKB0.66810113
62CDK190.65131747
63NEK10.57866866
64PBK0.57502496
65CCNB10.57008363
66CHEK20.56566901
67PLK40.56315143
68GRK70.56065941
69TESK20.55861967
70TRIM280.55410895
71PIM10.55050880
72ADRBK10.52564205
73MAPK40.50085686
74CAMKK20.46712620
75JAK30.46412928
76TTK0.46040769
77NLK0.44342864
78JAK10.44314951
79IRAK10.44074946
80DYRK1A0.43742522
81MAP3K50.42635688
82PIK3CG0.41816954
83TYRO30.40395412
84CHUK0.39111881
85DAPK20.38817895
86CSNK2A10.37227031
87CSNK1D0.36360332
88MAPKAPK20.35731972
89DYRK1B0.34929837
90MST40.34925797
91ITK0.33614344
92LYN0.32935928
93OXSR10.32489636
94CDK60.31339899
95MAP2K10.30995984
96IGF1R0.30874354
97PLK10.30457643
98RPS6KB20.29996072
99CSNK2A20.28656110
100ABL10.27432175

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.39298511
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.29863471
3Primary immunodeficiency_Homo sapiens_hsa053403.23199994
4Oxidative phosphorylation_Homo sapiens_hsa001902.96430751
5Parkinsons disease_Homo sapiens_hsa050122.78930374
6RNA polymerase_Homo sapiens_hsa030202.78626761
7Homologous recombination_Homo sapiens_hsa034402.58770757
8Ribosome_Homo sapiens_hsa030102.49466856
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.15528069
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.14887615
11Propanoate metabolism_Homo sapiens_hsa006402.07842811
12Non-homologous end-joining_Homo sapiens_hsa034501.99296308
13Spliceosome_Homo sapiens_hsa030401.89534047
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.89038337
15RNA degradation_Homo sapiens_hsa030181.88982996
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85003309
17Fatty acid elongation_Homo sapiens_hsa000621.83333903
18Protein export_Homo sapiens_hsa030601.76766633
19Basal transcription factors_Homo sapiens_hsa030221.72244115
20Nucleotide excision repair_Homo sapiens_hsa034201.67932523
21Mismatch repair_Homo sapiens_hsa034301.66206511
22Huntingtons disease_Homo sapiens_hsa050161.57638913
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57122867
24Alzheimers disease_Homo sapiens_hsa050101.52791560
25One carbon pool by folate_Homo sapiens_hsa006701.50798224
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48467788
27Autoimmune thyroid disease_Homo sapiens_hsa053201.41622222
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38869382
29Allograft rejection_Homo sapiens_hsa053301.37008820
30Linoleic acid metabolism_Homo sapiens_hsa005911.36291534
31Antigen processing and presentation_Homo sapiens_hsa046121.35799000
32Butanoate metabolism_Homo sapiens_hsa006501.34812257
33Pyrimidine metabolism_Homo sapiens_hsa002401.33124278
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.31768575
35Folate biosynthesis_Homo sapiens_hsa007901.31484352
36Graft-versus-host disease_Homo sapiens_hsa053321.27047647
37RNA transport_Homo sapiens_hsa030131.25330183
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23122730
39Fanconi anemia pathway_Homo sapiens_hsa034601.21446930
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18442849
41T cell receptor signaling pathway_Homo sapiens_hsa046601.16467905
42DNA replication_Homo sapiens_hsa030301.11880885
43Purine metabolism_Homo sapiens_hsa002301.11470265
44Type I diabetes mellitus_Homo sapiens_hsa049401.06943833
45Nitrogen metabolism_Homo sapiens_hsa009101.06498927
46Asthma_Homo sapiens_hsa053101.04993002
47Pyruvate metabolism_Homo sapiens_hsa006201.03124544
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02206536
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01299054
50Systemic lupus erythematosus_Homo sapiens_hsa053220.94099214
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93536381
52Rheumatoid arthritis_Homo sapiens_hsa053230.92948202
53Phototransduction_Homo sapiens_hsa047440.91737279
54Peroxisome_Homo sapiens_hsa041460.85426807
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80532677
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77996529
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76038275
58Epstein-Barr virus infection_Homo sapiens_hsa051690.75513887
59Fatty acid biosynthesis_Homo sapiens_hsa000610.71645041
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70831458
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67866506
62Tryptophan metabolism_Homo sapiens_hsa003800.66866703
63Arachidonic acid metabolism_Homo sapiens_hsa005900.65624225
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.65139210
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.64537262
66Vitamin digestion and absorption_Homo sapiens_hsa049770.63553245
67Taste transduction_Homo sapiens_hsa047420.62408127
68Cardiac muscle contraction_Homo sapiens_hsa042600.60489127
69beta-Alanine metabolism_Homo sapiens_hsa004100.59805102
70Fatty acid metabolism_Homo sapiens_hsa012120.58317370
71Metabolic pathways_Homo sapiens_hsa011000.58157178
72Hematopoietic cell lineage_Homo sapiens_hsa046400.58110468
73Legionellosis_Homo sapiens_hsa051340.57999304
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.57906870
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57481650
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56680073
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54658547
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52451663
79Prion diseases_Homo sapiens_hsa050200.52117293
80Measles_Homo sapiens_hsa051620.51334908
81p53 signaling pathway_Homo sapiens_hsa041150.47523321
82Fat digestion and absorption_Homo sapiens_hsa049750.47113804
83Base excision repair_Homo sapiens_hsa034100.43315846
84Sulfur relay system_Homo sapiens_hsa041220.42367578
85N-Glycan biosynthesis_Homo sapiens_hsa005100.40791267
86Ovarian steroidogenesis_Homo sapiens_hsa049130.38456674
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.38447621
88Chemical carcinogenesis_Homo sapiens_hsa052040.37555890
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37427548
90Regulation of autophagy_Homo sapiens_hsa041400.36693872
91Retinol metabolism_Homo sapiens_hsa008300.34039967
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33871793
93Steroid biosynthesis_Homo sapiens_hsa001000.33400563
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28870088
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.27253874
96Caffeine metabolism_Homo sapiens_hsa002320.26934881
97Viral myocarditis_Homo sapiens_hsa054160.26556470
98Ether lipid metabolism_Homo sapiens_hsa005650.24666125
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.23778281
100Arginine and proline metabolism_Homo sapiens_hsa003300.22618577

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