

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA deamination (GO:0045006) | 5.89834088 |
| 2 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 5.10417701 |
| 3 | protein-cofactor linkage (GO:0018065) | 4.82217203 |
| 4 | tolerance induction (GO:0002507) | 4.76458781 |
| 5 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.73916878 |
| 6 | cellular response to interleukin-15 (GO:0071350) | 4.72845002 |
| 7 | cytidine metabolic process (GO:0046087) | 4.66985293 |
| 8 | cytidine catabolic process (GO:0006216) | 4.66985293 |
| 9 | cytidine deamination (GO:0009972) | 4.66985293 |
| 10 | positive regulation of mitochondrial fission (GO:0090141) | 4.66241591 |
| 11 | ATP synthesis coupled proton transport (GO:0015986) | 4.54500404 |
| 12 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 4.54500404 |
| 13 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.52282198 |
| 14 | chaperone-mediated protein transport (GO:0072321) | 4.50559496 |
| 15 | peptidyl-arginine omega-N-methylation (GO:0035247) | 4.42998265 |
| 16 | rRNA methylation (GO:0031167) | 4.34972292 |
| 17 | protein neddylation (GO:0045116) | 4.34119322 |
| 18 | rRNA modification (GO:0000154) | 4.30483277 |
| 19 | cellular response to exogenous dsRNA (GO:0071360) | 4.04442442 |
| 20 | negative regulation of telomere maintenance (GO:0032205) | 4.04320923 |
| 21 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.01095876 |
| 22 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 3.99490182 |
| 23 | proteasome assembly (GO:0043248) | 3.93769558 |
| 24 | nucleotide-excision repair, DNA damage removal (GO:0000718) | 3.88917274 |
| 25 | DNA excision (GO:0044349) | 3.88917274 |
| 26 | negative regulation by host of viral transcription (GO:0043922) | 3.84371380 |
| 27 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.72465066 |
| 28 | peptidyl-arginine methylation (GO:0018216) | 3.65428343 |
| 29 | peptidyl-arginine N-methylation (GO:0035246) | 3.65428343 |
| 30 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.58841556 |
| 31 | response to interleukin-15 (GO:0070672) | 3.53803350 |
| 32 | regulation of mitochondrial translation (GO:0070129) | 3.52740992 |
| 33 | somatic recombination of immunoglobulin genes involved in immune response (GO:0002204) | 3.47243254 |
| 34 | somatic diversification of immunoglobulins involved in immune response (GO:0002208) | 3.47243254 |
| 35 | isotype switching (GO:0045190) | 3.47243254 |
| 36 | mannosylation (GO:0097502) | 3.42256524 |
| 37 | protein complex biogenesis (GO:0070271) | 3.41258452 |
| 38 | iron-sulfur cluster assembly (GO:0016226) | 3.30604939 |
| 39 | metallo-sulfur cluster assembly (GO:0031163) | 3.30604939 |
| 40 | regulation of mitochondrial fission (GO:0090140) | 3.27893529 |
| 41 | histone arginine methylation (GO:0034969) | 3.26993472 |
| 42 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.25035662 |
| 43 | pseudouridine synthesis (GO:0001522) | 3.22748444 |
| 44 | regulation of T cell receptor signaling pathway (GO:0050856) | 3.21463966 |
| 45 | inner mitochondrial membrane organization (GO:0007007) | 3.16768586 |
| 46 | negative regulation of heart rate (GO:0010459) | 3.16301877 |
| 47 | protein deneddylation (GO:0000338) | 3.14250277 |
| 48 | positive regulation of uterine smooth muscle contraction (GO:0070474) | 3.14170050 |
| 49 | regulation of defense response to virus by host (GO:0050691) | 3.10734737 |
| 50 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.10314558 |
| 51 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.06495913 |
| 52 | termination of RNA polymerase III transcription (GO:0006386) | 3.06495913 |
| 53 | DNA damage response, detection of DNA damage (GO:0042769) | 3.04515355 |
| 54 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.03286109 |
| 55 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.00644116 |
| 56 | mast cell activation involved in immune response (GO:0002279) | 2.99697438 |
| 57 | mast cell degranulation (GO:0043303) | 2.99697438 |
| 58 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 2.98824244 |
| 59 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 2.98824244 |
| 60 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 2.98824244 |
| 61 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.98031004 |
| 62 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 2.96533227 |
| 63 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 2.96533227 |
| 64 | RNA destabilization (GO:0050779) | 2.94761726 |
| 65 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 2.90542457 |
| 66 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 2.90542457 |
| 67 | ribosomal small subunit assembly (GO:0000028) | 2.90313648 |
| 68 | respiratory electron transport chain (GO:0022904) | 2.89881859 |
| 69 | cellular response to dsRNA (GO:0071359) | 2.89809933 |
| 70 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 2.89179092 |
| 71 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 2.89179092 |
| 72 | positive regulation of prostaglandin secretion (GO:0032308) | 2.88830661 |
| 73 | 7-methylguanosine mRNA capping (GO:0006370) | 2.87975607 |
| 74 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.87213430 |
| 75 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 2.86734423 |
| 76 | electron transport chain (GO:0022900) | 2.86069713 |
| 77 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 2.85447826 |
| 78 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.82430657 |
| 79 | negative regulation of ligase activity (GO:0051352) | 2.82430657 |
| 80 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.82205289 |
| 81 | 7-methylguanosine RNA capping (GO:0009452) | 2.80585630 |
| 82 | RNA capping (GO:0036260) | 2.80585630 |
| 83 | DNA ligation (GO:0006266) | 2.77467612 |
| 84 | platelet dense granule organization (GO:0060155) | 2.77461337 |
| 85 | lysosome localization (GO:0032418) | 2.76811988 |
| 86 | ATP biosynthetic process (GO:0006754) | 2.73962708 |
| 87 | respiratory chain complex IV assembly (GO:0008535) | 2.71968934 |
| 88 | ribosomal large subunit biogenesis (GO:0042273) | 2.71866613 |
| 89 | somatic diversification of immunoglobulins (GO:0016445) | 2.70907999 |
| 90 | regulation of chronic inflammatory response (GO:0002676) | 2.70628741 |
| 91 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.70360782 |
| 92 | regulation of gamma-delta T cell differentiation (GO:0045586) | 2.69922288 |
| 93 | monocyte chemotaxis (GO:0002548) | 2.69716192 |
| 94 | transcription from RNA polymerase I promoter (GO:0006360) | 2.69297833 |
| 95 | negative regulation of amino acid transport (GO:0051956) | 2.67983516 |
| 96 | termination of RNA polymerase I transcription (GO:0006363) | 2.67032036 |
| 97 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.62294484 |
| 98 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.61842323 |
| 99 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.60441895 |
| 100 | cullin deneddylation (GO:0010388) | 2.58918830 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.92299162 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.83143931 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.79622756 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.93693741 |
| 5 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.75242509 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.24755498 |
| 7 | ELK1_19687146_ChIP-ChIP_HELA_Human | 3.05275911 |
| 8 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.99863078 |
| 9 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.92549802 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.73218736 |
| 11 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.72147319 |
| 12 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.67235640 |
| 13 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 2.43588102 |
| 14 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.43290759 |
| 15 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.37865226 |
| 16 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.35483885 |
| 17 | GATA1_22025678_ChIP-Seq_K562_Human | 2.32996908 |
| 18 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 2.32915154 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.28070655 |
| 20 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.17569980 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 2.16914946 |
| 22 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 2.14884417 |
| 23 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.10030531 |
| 24 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.08601516 |
| 25 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.99505838 |
| 26 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.99384801 |
| 27 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.93970910 |
| 28 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.82608107 |
| 29 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.76162290 |
| 30 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.75255860 |
| 31 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.74771178 |
| 32 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.73494889 |
| 33 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.59930565 |
| 34 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.59334977 |
| 35 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.57916281 |
| 36 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 1.57077948 |
| 37 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.50835553 |
| 38 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.50602460 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.48532313 |
| 40 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.47380293 |
| 41 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.45514826 |
| 42 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.42270693 |
| 43 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.41279133 |
| 44 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.40995409 |
| 45 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.38640565 |
| 46 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.38289844 |
| 47 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.35292671 |
| 48 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.34672451 |
| 49 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.34469733 |
| 50 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.34314381 |
| 51 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.33185328 |
| 52 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 1.31797561 |
| 53 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.31435028 |
| 54 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.31175971 |
| 55 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.31117791 |
| 56 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.25608600 |
| 57 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.24465485 |
| 58 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.23467524 |
| 59 | AR_20517297_ChIP-Seq_VCAP_Human | 1.22340974 |
| 60 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.21528562 |
| 61 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.18525967 |
| 62 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.15752395 |
| 63 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.14780292 |
| 64 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.13292225 |
| 65 | MYB_26560356_Chip-Seq_TH2_Human | 1.13287063 |
| 66 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.13208687 |
| 67 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.12604576 |
| 68 | GATA3_26560356_Chip-Seq_TH2_Human | 1.11372588 |
| 69 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.10792500 |
| 70 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10697882 |
| 71 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 1.09419123 |
| 72 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.08559112 |
| 73 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.08524091 |
| 74 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.07804471 |
| 75 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.06704636 |
| 76 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 1.05028271 |
| 77 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 1.05028271 |
| 78 | FUS_26573619_Chip-Seq_HEK293_Human | 1.03356461 |
| 79 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.02850955 |
| 80 | EWS_26573619_Chip-Seq_HEK293_Human | 1.00581122 |
| 81 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.00351946 |
| 82 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.99366698 |
| 83 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 0.94868765 |
| 84 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.94460833 |
| 85 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 0.94409496 |
| 86 | TAF2_19829295_ChIP-Seq_ESCs_Human | 0.92693551 |
| 87 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.91251212 |
| 88 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.91080582 |
| 89 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89993069 |
| 90 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.89220077 |
| 91 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.88563683 |
| 92 | TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.88330773 |
| 93 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 0.87648949 |
| 94 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.87348772 |
| 95 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.87348772 |
| 96 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.87065186 |
| 97 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.86988063 |
| 98 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.86195252 |
| 99 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 0.86177615 |
| 100 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.84366269 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008877_abnormal_DNA_methylation | 3.56328063 |
| 2 | MP0005671_abnormal_response_to | 3.40979291 |
| 3 | MP0008058_abnormal_DNA_repair | 3.10006152 |
| 4 | MP0008007_abnormal_cellular_replicative | 2.81348606 |
| 5 | MP0002254_reproductive_system_inflammat | 2.63584767 |
| 6 | MP0004133_heterotaxia | 2.61053287 |
| 7 | MP0008875_abnormal_xenobiotic_pharmacok | 2.60137413 |
| 8 | MP0002166_altered_tumor_susceptibility | 2.37645585 |
| 9 | MP0002277_abnormal_respiratory_mucosa | 2.33395186 |
| 10 | MP0006072_abnormal_retinal_apoptosis | 2.26810535 |
| 11 | MP0002006_tumorigenesis | 2.26648957 |
| 12 | MP0002102_abnormal_ear_morphology | 2.22566450 |
| 13 | MP0003763_abnormal_thymus_physiology | 2.21781708 |
| 14 | MP0006035_abnormal_mitochondrial_morpho | 2.10315188 |
| 15 | MP0002138_abnormal_hepatobiliary_system | 2.08887118 |
| 16 | MP0005646_abnormal_pituitary_gland | 1.92568392 |
| 17 | MP0006036_abnormal_mitochondrial_physio | 1.90296813 |
| 18 | MP0005075_abnormal_melanosome_morpholog | 1.88746014 |
| 19 | MP0004147_increased_porphyrin_level | 1.88702771 |
| 20 | MP0002148_abnormal_hypersensitivity_rea | 1.83166297 |
| 21 | MP0001919_abnormal_reproductive_system | 1.82463613 |
| 22 | MP0005410_abnormal_fertilization | 1.79546882 |
| 23 | MP0001529_abnormal_vocalization | 1.73195497 |
| 24 | MP0003786_premature_aging | 1.72632442 |
| 25 | MP0008789_abnormal_olfactory_epithelium | 1.71317955 |
| 26 | MP0003111_abnormal_nucleus_morphology | 1.67454914 |
| 27 | MP0005000_abnormal_immune_tolerance | 1.66803086 |
| 28 | MP0003136_yellow_coat_color | 1.63649778 |
| 29 | MP0002653_abnormal_ependyma_morphology | 1.58994921 |
| 30 | MP0002822_catalepsy | 1.58558216 |
| 31 | MP0006292_abnormal_olfactory_placode | 1.57691624 |
| 32 | MP0002009_preneoplasia | 1.54941335 |
| 33 | MP0005167_abnormal_blood-brain_barrier | 1.54922597 |
| 34 | MP0010094_abnormal_chromosome_stability | 1.52511385 |
| 35 | MP0001800_abnormal_humoral_immune | 1.51170728 |
| 36 | MP0001986_abnormal_taste_sensitivity | 1.49518634 |
| 37 | MP0008872_abnormal_physiological_respon | 1.44637614 |
| 38 | MP0005551_abnormal_eye_electrophysiolog | 1.44522509 |
| 39 | MP0002723_abnormal_immune_serum | 1.41382497 |
| 40 | MP0003252_abnormal_bile_duct | 1.36051429 |
| 41 | MP0001835_abnormal_antigen_presentation | 1.33665129 |
| 42 | MP0001905_abnormal_dopamine_level | 1.32024908 |
| 43 | MP0009333_abnormal_splenocyte_physiolog | 1.29912148 |
| 44 | MP0001853_heart_inflammation | 1.28727895 |
| 45 | MP0005389_reproductive_system_phenotype | 1.27144688 |
| 46 | MP0003011_delayed_dark_adaptation | 1.26845318 |
| 47 | MP0004043_abnormal_pH_regulation | 1.25927075 |
| 48 | MP0004142_abnormal_muscle_tone | 1.24937155 |
| 49 | MP0001984_abnormal_olfaction | 1.21461821 |
| 50 | MP0004742_abnormal_vestibular_system | 1.19558306 |
| 51 | MP0003718_maternal_effect | 1.14909996 |
| 52 | MP0005394_taste/olfaction_phenotype | 1.14776269 |
| 53 | MP0005499_abnormal_olfactory_system | 1.14776269 |
| 54 | MP0001790_abnormal_immune_system | 1.12815578 |
| 55 | MP0005387_immune_system_phenotype | 1.12815578 |
| 56 | MP0002928_abnormal_bile_duct | 1.12677486 |
| 57 | MP0001819_abnormal_immune_cell | 1.12195823 |
| 58 | MP0002452_abnormal_antigen_presenting | 1.11019711 |
| 59 | MP0002420_abnormal_adaptive_immunity | 1.09808922 |
| 60 | MP0002837_dystrophic_cardiac_calcinosis | 1.05445417 |
| 61 | MP0003866_abnormal_defecation | 1.05420831 |
| 62 | MP0000569_abnormal_digit_pigmentation | 1.05199889 |
| 63 | MP0000703_abnormal_thymus_morphology | 1.03568643 |
| 64 | MP0008932_abnormal_embryonic_tissue | 1.02565393 |
| 65 | MP0005253_abnormal_eye_physiology | 1.02125030 |
| 66 | MP0003806_abnormal_nucleotide_metabolis | 1.01782292 |
| 67 | MP0003724_increased_susceptibility_to | 1.01422353 |
| 68 | MP0009785_altered_susceptibility_to | 1.01106875 |
| 69 | MP0005084_abnormal_gallbladder_morpholo | 1.00463776 |
| 70 | MP0002933_joint_inflammation | 0.99633275 |
| 71 | MP0001968_abnormal_touch/_nociception | 0.97284157 |
| 72 | MP0004145_abnormal_muscle_electrophysio | 0.96727205 |
| 73 | MP0002722_abnormal_immune_system | 0.96133677 |
| 74 | MP0002938_white_spotting | 0.94745956 |
| 75 | MP0000685_abnormal_immune_system | 0.94042837 |
| 76 | MP0000358_abnormal_cell_content/ | 0.93451582 |
| 77 | MP0001485_abnormal_pinna_reflex | 0.91828144 |
| 78 | MP0000689_abnormal_spleen_morphology | 0.91276802 |
| 79 | MP0003693_abnormal_embryo_hatching | 0.91128301 |
| 80 | MP0003880_abnormal_central_pattern | 0.89364655 |
| 81 | MP0001764_abnormal_homeostasis | 0.88140314 |
| 82 | MP0001188_hyperpigmentation | 0.87451186 |
| 83 | MP0006082_CNS_inflammation | 0.85781988 |
| 84 | MP0009764_decreased_sensitivity_to | 0.84465696 |
| 85 | MP0000631_abnormal_neuroendocrine_gland | 0.84239390 |
| 86 | MP0005025_abnormal_response_to | 0.82125414 |
| 87 | MP0001293_anophthalmia | 0.81121123 |
| 88 | MP0004957_abnormal_blastocyst_morpholog | 0.80108899 |
| 89 | MP0000427_abnormal_hair_cycle | 0.79464664 |
| 90 | MP0002160_abnormal_reproductive_system | 0.79087301 |
| 91 | MP0002272_abnormal_nervous_system | 0.76588486 |
| 92 | MP0000716_abnormal_immune_system | 0.76252012 |
| 93 | MP0005085_abnormal_gallbladder_physiolo | 0.75463799 |
| 94 | MP0000372_irregular_coat_pigmentation | 0.75402956 |
| 95 | MP0010155_abnormal_intestine_physiology | 0.75198739 |
| 96 | MP0002736_abnormal_nociception_after | 0.74477787 |
| 97 | MP0003567_abnormal_fetal_cardiomyocyte | 0.74193629 |
| 98 | MP0001929_abnormal_gametogenesis | 0.73669137 |
| 99 | MP0003638_abnormal_response/metabolism_ | 0.73003344 |
| 100 | MP0002398_abnormal_bone_marrow | 0.70414873 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.45545962 |
| 2 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.45545962 |
| 3 | IgG deficiency (HP:0004315) | 4.08253674 |
| 4 | Increased intramyocellular lipid droplets (HP:0012240) | 3.96874071 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.73111277 |
| 6 | IgM deficiency (HP:0002850) | 3.42134038 |
| 7 | Bilateral microphthalmos (HP:0007633) | 3.35561815 |
| 8 | Increased CSF lactate (HP:0002490) | 3.28353761 |
| 9 | Anterior segment dysgenesis (HP:0007700) | 3.25827048 |
| 10 | Mitochondrial inheritance (HP:0001427) | 3.24361895 |
| 11 | Increased muscle lipid content (HP:0009058) | 3.20357980 |
| 12 | Acute necrotizing encephalopathy (HP:0006965) | 3.08381734 |
| 13 | Abnormality of B cell number (HP:0010975) | 3.05660531 |
| 14 | Increased hepatocellular lipid droplets (HP:0006565) | 3.04845684 |
| 15 | Dyschromatopsia (HP:0007641) | 3.03582518 |
| 16 | Abnormality of the prostate (HP:0008775) | 3.02888567 |
| 17 | Oligodactyly (hands) (HP:0001180) | 3.01829921 |
| 18 | Hepatocellular necrosis (HP:0001404) | 3.01533398 |
| 19 | Severe combined immunodeficiency (HP:0004430) | 2.91414570 |
| 20 | Nephronophthisis (HP:0000090) | 2.91241903 |
| 21 | Abolished electroretinogram (ERG) (HP:0000550) | 2.85186880 |
| 22 | Retinal dysplasia (HP:0007973) | 2.79079939 |
| 23 | Stomatitis (HP:0010280) | 2.78900260 |
| 24 | Type II lissencephaly (HP:0007260) | 2.77510226 |
| 25 | Acute encephalopathy (HP:0006846) | 2.75512880 |
| 26 | Tubulointerstitial nephritis (HP:0001970) | 2.70729198 |
| 27 | Abnormality of the renal medulla (HP:0100957) | 2.66487285 |
| 28 | Chorioretinal atrophy (HP:0000533) | 2.62386041 |
| 29 | B lymphocytopenia (HP:0010976) | 2.60921273 |
| 30 | Medial flaring of the eyebrow (HP:0010747) | 2.59964349 |
| 31 | Lipid accumulation in hepatocytes (HP:0006561) | 2.58200893 |
| 32 | Hepatic necrosis (HP:0002605) | 2.57336925 |
| 33 | Supernumerary spleens (HP:0009799) | 2.51520084 |
| 34 | Prostate neoplasm (HP:0100787) | 2.47138304 |
| 35 | Methylmalonic aciduria (HP:0012120) | 2.45886771 |
| 36 | Increased serum lactate (HP:0002151) | 2.45316765 |
| 37 | Pancreatic cysts (HP:0001737) | 2.43252587 |
| 38 | Renal cortical cysts (HP:0000803) | 2.39590710 |
| 39 | Progressive macrocephaly (HP:0004481) | 2.39447573 |
| 40 | Optic disc pallor (HP:0000543) | 2.38552175 |
| 41 | 3-Methylglutaconic aciduria (HP:0003535) | 2.37294944 |
| 42 | Lactic acidosis (HP:0003128) | 2.35442770 |
| 43 | Combined immunodeficiency (HP:0005387) | 2.31387300 |
| 44 | Increased serum pyruvate (HP:0003542) | 2.31006524 |
| 45 | Type I transferrin isoform profile (HP:0003642) | 2.29225261 |
| 46 | Abnormality of the renal cortex (HP:0011035) | 2.26674010 |
| 47 | Methylmalonic acidemia (HP:0002912) | 2.21603236 |
| 48 | Cerebellar dysplasia (HP:0007033) | 2.19875044 |
| 49 | Abnormality of T cells (HP:0002843) | 2.17568773 |
| 50 | Oral leukoplakia (HP:0002745) | 2.16655715 |
| 51 | CNS hypomyelination (HP:0003429) | 2.16418786 |
| 52 | Posterior subcapsular cataract (HP:0007787) | 2.15748492 |
| 53 | Severe muscular hypotonia (HP:0006829) | 2.14713205 |
| 54 | Congenital stationary night blindness (HP:0007642) | 2.12142689 |
| 55 | Brittle hair (HP:0002299) | 2.11670267 |
| 56 | Cerebral edema (HP:0002181) | 2.06823675 |
| 57 | Abnormality of T cell physiology (HP:0011840) | 2.06755844 |
| 58 | Thyroiditis (HP:0100646) | 2.06683226 |
| 59 | Neuroendocrine neoplasm (HP:0100634) | 2.06660114 |
| 60 | Oligodactyly (HP:0012165) | 2.05296593 |
| 61 | Autoimmune thrombocytopenia (HP:0001973) | 2.02607809 |
| 62 | Aplasia/hypoplasia of the uterus (HP:0008684) | 2.02385888 |
| 63 | Meckel diverticulum (HP:0002245) | 2.02295018 |
| 64 | Abnormal number of erythroid precursors (HP:0012131) | 2.02084213 |
| 65 | Parakeratosis (HP:0001036) | 2.01909493 |
| 66 | Pendular nystagmus (HP:0012043) | 2.01795727 |
| 67 | Abnormality of T cell number (HP:0011839) | 2.01560125 |
| 68 | Inability to walk (HP:0002540) | 1.97341170 |
| 69 | Abnormality of the ileum (HP:0001549) | 1.96271945 |
| 70 | Central scotoma (HP:0000603) | 1.95562868 |
| 71 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.95327973 |
| 72 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.95327973 |
| 73 | Abnormal protein glycosylation (HP:0012346) | 1.95327973 |
| 74 | Abnormal glycosylation (HP:0012345) | 1.95327973 |
| 75 | Exertional dyspnea (HP:0002875) | 1.94594990 |
| 76 | Nephrogenic diabetes insipidus (HP:0009806) | 1.92680725 |
| 77 | Fibular aplasia (HP:0002990) | 1.90545295 |
| 78 | Renal Fanconi syndrome (HP:0001994) | 1.88358228 |
| 79 | Lethargy (HP:0001254) | 1.87080675 |
| 80 | Bile duct proliferation (HP:0001408) | 1.86292347 |
| 81 | Abnormal biliary tract physiology (HP:0012439) | 1.86292347 |
| 82 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 1.85512788 |
| 83 | Attenuation of retinal blood vessels (HP:0007843) | 1.84486714 |
| 84 | Hyperglycinuria (HP:0003108) | 1.82972720 |
| 85 | Respiratory failure (HP:0002878) | 1.82334084 |
| 86 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 1.82272124 |
| 87 | Abnormality of alanine metabolism (HP:0010916) | 1.81364843 |
| 88 | Hyperalaninemia (HP:0003348) | 1.81364843 |
| 89 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.81364843 |
| 90 | Exercise intolerance (HP:0003546) | 1.81310570 |
| 91 | Abnormal spermatogenesis (HP:0008669) | 1.81282799 |
| 92 | Pulmonary fibrosis (HP:0002206) | 1.80476998 |
| 93 | True hermaphroditism (HP:0010459) | 1.80155087 |
| 94 | Abnormality of eosinophils (HP:0001879) | 1.79472404 |
| 95 | T lymphocytopenia (HP:0005403) | 1.79077854 |
| 96 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.78275765 |
| 97 | Abnormality of the pons (HP:0007361) | 1.75092894 |
| 98 | Abnormality of glycolysis (HP:0004366) | 1.74856153 |
| 99 | Molar tooth sign on MRI (HP:0002419) | 1.71724370 |
| 100 | Abnormality of midbrain morphology (HP:0002418) | 1.71724370 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TXK | 5.15624379 |
| 2 | TSSK6 | 4.61755087 |
| 3 | TLK1 | 3.30214567 |
| 4 | VRK2 | 2.95358886 |
| 5 | ZAK | 2.78747105 |
| 6 | BUB1 | 2.58551253 |
| 7 | NUAK1 | 2.47006322 |
| 8 | VRK1 | 2.44862461 |
| 9 | MAPKAPK3 | 2.32658301 |
| 10 | BCKDK | 2.30823179 |
| 11 | MAP2K2 | 2.17713378 |
| 12 | TAOK3 | 2.17483599 |
| 13 | MAPK15 | 2.06624295 |
| 14 | IKBKE | 2.00278594 |
| 15 | CSNK1G1 | 1.59296644 |
| 16 | DAPK1 | 1.58017226 |
| 17 | IKBKB | 1.53408544 |
| 18 | MAP3K13 | 1.48813870 |
| 19 | CSNK1G3 | 1.46438978 |
| 20 | TBK1 | 1.46170051 |
| 21 | WNK3 | 1.45554072 |
| 22 | CSNK1A1L | 1.44831806 |
| 23 | TAF1 | 1.40051436 |
| 24 | MKNK1 | 1.36131584 |
| 25 | PRKCI | 1.23495861 |
| 26 | MAP3K14 | 1.23192374 |
| 27 | GRK1 | 1.18322953 |
| 28 | BCR | 1.17467112 |
| 29 | ADRBK2 | 1.14070542 |
| 30 | CSNK1G2 | 1.13822134 |
| 31 | PRKCQ | 1.10621234 |
| 32 | PLK3 | 1.10276306 |
| 33 | MAPKAPK5 | 1.09633481 |
| 34 | EIF2AK2 | 1.09030599 |
| 35 | PDK2 | 1.06684494 |
| 36 | KDR | 1.03945163 |
| 37 | STK16 | 1.01682085 |
| 38 | KIT | 0.94138808 |
| 39 | EIF2AK1 | 0.89535682 |
| 40 | NTRK3 | 0.89125593 |
| 41 | MKNK2 | 0.88452609 |
| 42 | PINK1 | 0.86853426 |
| 43 | CLK1 | 0.86528324 |
| 44 | EPHA4 | 0.84064237 |
| 45 | BRSK2 | 0.82227999 |
| 46 | RPS6KA5 | 0.81683727 |
| 47 | DYRK2 | 0.80587124 |
| 48 | BMPR2 | 0.78145107 |
| 49 | SRPK1 | 0.77346407 |
| 50 | SYK | 0.76144375 |
| 51 | MAP3K9 | 0.76080057 |
| 52 | PIM2 | 0.76059000 |
| 53 | MAP4K2 | 0.75868684 |
| 54 | LCK | 0.74279787 |
| 55 | WNK4 | 0.70925736 |
| 56 | DAPK3 | 0.70778191 |
| 57 | PHKG2 | 0.69695740 |
| 58 | PHKG1 | 0.69695740 |
| 59 | TIE1 | 0.69637989 |
| 60 | WEE1 | 0.68178241 |
| 61 | AURKB | 0.66810113 |
| 62 | CDK19 | 0.65131747 |
| 63 | NEK1 | 0.57866866 |
| 64 | PBK | 0.57502496 |
| 65 | CCNB1 | 0.57008363 |
| 66 | CHEK2 | 0.56566901 |
| 67 | PLK4 | 0.56315143 |
| 68 | GRK7 | 0.56065941 |
| 69 | TESK2 | 0.55861967 |
| 70 | TRIM28 | 0.55410895 |
| 71 | PIM1 | 0.55050880 |
| 72 | ADRBK1 | 0.52564205 |
| 73 | MAPK4 | 0.50085686 |
| 74 | CAMKK2 | 0.46712620 |
| 75 | JAK3 | 0.46412928 |
| 76 | TTK | 0.46040769 |
| 77 | NLK | 0.44342864 |
| 78 | JAK1 | 0.44314951 |
| 79 | IRAK1 | 0.44074946 |
| 80 | DYRK1A | 0.43742522 |
| 81 | MAP3K5 | 0.42635688 |
| 82 | PIK3CG | 0.41816954 |
| 83 | TYRO3 | 0.40395412 |
| 84 | CHUK | 0.39111881 |
| 85 | DAPK2 | 0.38817895 |
| 86 | CSNK2A1 | 0.37227031 |
| 87 | CSNK1D | 0.36360332 |
| 88 | MAPKAPK2 | 0.35731972 |
| 89 | DYRK1B | 0.34929837 |
| 90 | MST4 | 0.34925797 |
| 91 | ITK | 0.33614344 |
| 92 | LYN | 0.32935928 |
| 93 | OXSR1 | 0.32489636 |
| 94 | CDK6 | 0.31339899 |
| 95 | MAP2K1 | 0.30995984 |
| 96 | IGF1R | 0.30874354 |
| 97 | PLK1 | 0.30457643 |
| 98 | RPS6KB2 | 0.29996072 |
| 99 | CSNK2A2 | 0.28656110 |
| 100 | ABL1 | 0.27432175 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.39298511 |
| 2 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 3.29863471 |
| 3 | Primary immunodeficiency_Homo sapiens_hsa05340 | 3.23199994 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.96430751 |
| 5 | Parkinsons disease_Homo sapiens_hsa05012 | 2.78930374 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.78626761 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.58770757 |
| 8 | Ribosome_Homo sapiens_hsa03010 | 2.49466856 |
| 9 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 2.15528069 |
| 10 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 2.14887615 |
| 11 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.07842811 |
| 12 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.99296308 |
| 13 | Spliceosome_Homo sapiens_hsa03040 | 1.89534047 |
| 14 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 1.89038337 |
| 15 | RNA degradation_Homo sapiens_hsa03018 | 1.88982996 |
| 16 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.85003309 |
| 17 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.83333903 |
| 18 | Protein export_Homo sapiens_hsa03060 | 1.76766633 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.72244115 |
| 20 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.67932523 |
| 21 | Mismatch repair_Homo sapiens_hsa03430 | 1.66206511 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.57638913 |
| 23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.57122867 |
| 24 | Alzheimers disease_Homo sapiens_hsa05010 | 1.52791560 |
| 25 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.50798224 |
| 26 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.48467788 |
| 27 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 1.41622222 |
| 28 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 1.38869382 |
| 29 | Allograft rejection_Homo sapiens_hsa05330 | 1.37008820 |
| 30 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 1.36291534 |
| 31 | Antigen processing and presentation_Homo sapiens_hsa04612 | 1.35799000 |
| 32 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.34812257 |
| 33 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.33124278 |
| 34 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.31768575 |
| 35 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.31484352 |
| 36 | Graft-versus-host disease_Homo sapiens_hsa05332 | 1.27047647 |
| 37 | RNA transport_Homo sapiens_hsa03013 | 1.25330183 |
| 38 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.23122730 |
| 39 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.21446930 |
| 40 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.18442849 |
| 41 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 1.16467905 |
| 42 | DNA replication_Homo sapiens_hsa03030 | 1.11880885 |
| 43 | Purine metabolism_Homo sapiens_hsa00230 | 1.11470265 |
| 44 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 1.06943833 |
| 45 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.06498927 |
| 46 | Asthma_Homo sapiens_hsa05310 | 1.04993002 |
| 47 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.03124544 |
| 48 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.02206536 |
| 49 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 1.01299054 |
| 50 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.94099214 |
| 51 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.93536381 |
| 52 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.92948202 |
| 53 | Phototransduction_Homo sapiens_hsa04744 | 0.91737279 |
| 54 | Peroxisome_Homo sapiens_hsa04146 | 0.85426807 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.80532677 |
| 56 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.77996529 |
| 57 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.76038275 |
| 58 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.75513887 |
| 59 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.71645041 |
| 60 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.70831458 |
| 61 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.67866506 |
| 62 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.66866703 |
| 63 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.65624225 |
| 64 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.65139210 |
| 65 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.64537262 |
| 66 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.63553245 |
| 67 | Taste transduction_Homo sapiens_hsa04742 | 0.62408127 |
| 68 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60489127 |
| 69 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.59805102 |
| 70 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.58317370 |
| 71 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58157178 |
| 72 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.58110468 |
| 73 | Legionellosis_Homo sapiens_hsa05134 | 0.57999304 |
| 74 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.57906870 |
| 75 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.57481650 |
| 76 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.56680073 |
| 77 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.54658547 |
| 78 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.52451663 |
| 79 | Prion diseases_Homo sapiens_hsa05020 | 0.52117293 |
| 80 | Measles_Homo sapiens_hsa05162 | 0.51334908 |
| 81 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.47523321 |
| 82 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.47113804 |
| 83 | Base excision repair_Homo sapiens_hsa03410 | 0.43315846 |
| 84 | Sulfur relay system_Homo sapiens_hsa04122 | 0.42367578 |
| 85 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.40791267 |
| 86 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.38456674 |
| 87 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.38447621 |
| 88 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.37555890 |
| 89 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.37427548 |
| 90 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.36693872 |
| 91 | Retinol metabolism_Homo sapiens_hsa00830 | 0.34039967 |
| 92 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.33871793 |
| 93 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.33400563 |
| 94 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.28870088 |
| 95 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.27253874 |
| 96 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.26934881 |
| 97 | Viral myocarditis_Homo sapiens_hsa05416 | 0.26556470 |
| 98 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.24666125 |
| 99 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.23778281 |
| 100 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.22618577 |

