STK10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.93055448
2negative regulation of cell killing (GO:0031342)5.89795103
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.89795103
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.69255736
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.69255736
6positive thymic T cell selection (GO:0045059)5.68637785
7regulation of gamma-delta T cell differentiation (GO:0045586)5.59037667
8negative T cell selection (GO:0043383)5.44521811
9negative thymic T cell selection (GO:0045060)5.42599869
10antigen processing and presentation of endogenous antigen (GO:0019883)5.34786238
11regulation of gamma-delta T cell activation (GO:0046643)5.24582369
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.15525541
13regulation of B cell receptor signaling pathway (GO:0050855)5.12431011
14thymic T cell selection (GO:0045061)4.87688090
15positive T cell selection (GO:0043368)4.82530063
16response to interleukin-15 (GO:0070672)4.69001532
17T cell selection (GO:0045058)4.53547580
18tolerance induction (GO:0002507)4.49389161
19macrophage activation involved in immune response (GO:0002281)4.42733984
20interferon-gamma production (GO:0032609)4.38587560
21T cell migration (GO:0072678)4.36982214
22neutrophil activation involved in immune response (GO:0002283)4.34551646
23detection of other organism (GO:0098543)4.31939154
24cellular response to interleukin-15 (GO:0071350)4.28481093
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.22593499
26detection of bacterium (GO:0016045)4.16810852
27B cell receptor signaling pathway (GO:0050853)4.16127131
28response to peptidoglycan (GO:0032494)4.10137906
29regulation of B cell differentiation (GO:0045577)4.01718636
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99762184
31regulation of T cell tolerance induction (GO:0002664)3.99437120
32regulation of interleukin-12 biosynthetic process (GO:0045075)3.88853683
33cellular extravasation (GO:0045123)3.70158999
34* leukocyte aggregation (GO:0070486)3.66850075
35positive regulation of B cell differentiation (GO:0045579)3.65541557
36antigen receptor-mediated signaling pathway (GO:0050851)3.64049966
37regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.63654150
38T cell receptor signaling pathway (GO:0050852)3.63642899
39detection of external biotic stimulus (GO:0098581)3.62610808
40regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.58380711
41positive regulation of tolerance induction (GO:0002645)3.57191078
42activated T cell proliferation (GO:0050798)3.57150194
43negative regulation of leukocyte mediated immunity (GO:0002704)3.56387753
44T cell costimulation (GO:0031295)3.54525473
45lymphocyte costimulation (GO:0031294)3.47325929
46regulation of alpha-beta T cell proliferation (GO:0046640)3.44299321
47negative regulation of erythrocyte differentiation (GO:0045647)3.42747564
48type I interferon signaling pathway (GO:0060337)3.41595936
49cellular response to type I interferon (GO:0071357)3.41595936
50myeloid cell activation involved in immune response (GO:0002275)3.40983134
51detection of molecule of bacterial origin (GO:0032490)3.40501525
52negative regulation of interleukin-12 production (GO:0032695)3.36997473
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.36716771
54regulation of isotype switching to IgG isotypes (GO:0048302)3.35206915
55response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33139746
56response to host immune response (GO:0052572)3.33139746
57microglial cell activation (GO:0001774)3.32836572
58granulocyte activation (GO:0036230)3.30314787
59positive regulation of interleukin-2 production (GO:0032743)3.29813214
60regulation of mast cell degranulation (GO:0043304)3.27835799
61* leukocyte cell-cell adhesion (GO:0007159)3.25751819
62regulation of interleukin-2 biosynthetic process (GO:0045076)3.25094524
63regulation of tolerance induction (GO:0002643)3.20790007
64detection of biotic stimulus (GO:0009595)3.19695410
65modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.18631029
66positive regulation by organism of defense response of other organism involved in symbiotic interact3.18631029
67modulation by symbiont of host immune response (GO:0052553)3.18631029
68positive regulation by symbiont of host defense response (GO:0052509)3.18631029
69modulation by symbiont of host defense response (GO:0052031)3.18631029
70modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.18631029
71macrophage activation (GO:0042116)3.18162184
72defense response to protozoan (GO:0042832)3.14973291
73response to host (GO:0075136)3.14100829
74response to host defenses (GO:0052200)3.14100829
75response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.14100829
76positive regulation of isotype switching (GO:0045830)3.11374489
77regulation of T cell receptor signaling pathway (GO:0050856)3.07919849
78JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07295191
79NIK/NF-kappaB signaling (GO:0038061)3.06420383
80Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05839174
81regulation of interferon-beta biosynthetic process (GO:0045357)3.05107175
82T cell homeostasis (GO:0043029)3.03442431
83lymphocyte homeostasis (GO:0002260)3.01840717
84regulation of T cell mediated cytotoxicity (GO:0001914)3.01686599
85mast cell activation (GO:0045576)3.00613428
86positive regulation of alpha-beta T cell proliferation (GO:0046641)3.00048281
87regulation of mast cell activation involved in immune response (GO:0033006)2.99820331
88positive regulation of mast cell activation (GO:0033005)2.98641031
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98493934
90positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.97197289
91regulation of type I interferon-mediated signaling pathway (GO:0060338)2.97011798
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96763111
93response to protozoan (GO:0001562)2.96556439
94neutrophil mediated immunity (GO:0002446)2.95933548
95regulation of response to interferon-gamma (GO:0060330)2.94789028
96regulation of leukocyte degranulation (GO:0043300)2.94449386
97regulation of dendritic cell antigen processing and presentation (GO:0002604)2.94224731
98negative regulation of phagocytosis (GO:0050765)2.94151967
99regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.91157712
100immune response-activating cell surface receptor signaling pathway (GO:0002429)2.90814447
101leukocyte degranulation (GO:0043299)2.90349558
102negative regulation of innate immune response (GO:0045824)2.90121388
103negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.89741673
104regulation of mast cell activation (GO:0033003)2.88855423
105lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88782784
106natural killer cell differentiation (GO:0001779)2.88582946
107B cell homeostasis (GO:0001782)2.87554812
108response to muramyl dipeptide (GO:0032495)2.87529007
109positive regulation of T cell mediated cytotoxicity (GO:0001916)2.86656680
110positive regulation of histone deacetylation (GO:0031065)2.86640036
111T cell proliferation (GO:0042098)2.86149937
112natural killer cell activation (GO:0030101)2.85652537
113B cell mediated immunity (GO:0019724)2.85156944
114mature B cell differentiation (GO:0002335)2.84295748
115myeloid dendritic cell activation (GO:0001773)2.83956176
116negative regulation of interleukin-6 production (GO:0032715)2.83730325
117regulation of antigen processing and presentation (GO:0002577)2.82494313
118regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.79518020
119regulation of natural killer cell mediated immunity (GO:0002715)2.79518020
120interferon-gamma-mediated signaling pathway (GO:0060333)2.78816894
121negative regulation of T cell mediated immunity (GO:0002710)2.76585626
122immunoglobulin mediated immune response (GO:0016064)2.75247459
123hepatocyte apoptotic process (GO:0097284)2.71040819
124regulation of isotype switching (GO:0045191)2.69346099
125positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.69074817
126positive regulation of granulocyte differentiation (GO:0030854)2.68878219
127regulation of regulatory T cell differentiation (GO:0045589)2.68228729
128positive regulation of humoral immune response (GO:0002922)2.67483082
129germinal center formation (GO:0002467)2.65426065
130heterotypic cell-cell adhesion (GO:0034113)2.65346295
131antigen processing and presentation via MHC class Ib (GO:0002475)2.63348639
132regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.62921623
133positive regulation of immunoglobulin mediated immune response (GO:0002891)2.62836792
134positive regulation of B cell mediated immunity (GO:0002714)2.62836792
135response to type I interferon (GO:0034340)2.62308897
136negative regulation of lymphocyte mediated immunity (GO:0002707)2.61609629
137respiratory burst (GO:0045730)2.61010824
138regulation of interleukin-2 production (GO:0032663)2.60607919
139B cell proliferation (GO:0042100)2.59995142
140regulation of B cell proliferation (GO:0030888)2.59642395
141response to laminar fluid shear stress (GO:0034616)2.59072656
142neutrophil activation (GO:0042119)2.58429272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.68435875
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.91404862
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.15136418
4E2F7_22180533_ChIP-Seq_HELA_Human3.78785478
5MYC_22102868_ChIP-Seq_BL_Human3.68522970
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.34026863
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.33864777
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33666693
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.28386713
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.14403855
11RUNX_20019798_ChIP-Seq_JUKART_Human3.08720472
12* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.04325130
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.95722423
14MYB_26560356_Chip-Seq_TH2_Human2.85306067
15VDR_21846776_ChIP-Seq_THP-1_Human2.84802698
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79714864
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.74314529
18MAF_26560356_Chip-Seq_TH1_Human2.71086205
19SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68492664
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.61527734
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.56348700
22MYB_26560356_Chip-Seq_TH1_Human2.55571158
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.51820191
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51350992
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49702736
26UTX_26944678_Chip-Seq_JUKART_Human2.47727252
27SCL_19346495_ChIP-Seq_HPC-7_Human2.35437747
28TCF7_22412390_ChIP-Seq_EML_Mouse2.27217086
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.23437738
30* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18969447
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13311679
32SPI1_23547873_ChIP-Seq_NB4_Human2.11400849
33VDR_24763502_ChIP-Seq_THP-1_Human2.11248369
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.08763528
35RUNX1_22412390_ChIP-Seq_EML_Mouse2.07943261
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.03758645
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03359044
38ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.99953712
39SPI1_23127762_ChIP-Seq_K562_Human1.84491617
40KDM2B_26808549_Chip-Seq_DND41_Human1.84151537
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82574685
42MAF_26560356_Chip-Seq_TH2_Human1.80624875
43GATA3_27048872_Chip-Seq_THYMUS_Human1.75249183
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73390771
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.69309098
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68132258
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64267734
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.56858374
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50077956
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49080538
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45628428
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.44305720
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43811520
54* PU_27001747_Chip-Seq_BMDM_Mouse1.39177689
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38024358
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37177647
57GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35691519
58* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33299064
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28561192
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28082838
61CIITA_25753668_ChIP-Seq_RAJI_Human1.22879786
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22155685
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21467434
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19022551
65* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17166297
66* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15230824
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12770349
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12312174
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11808645
70* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09941956
71* KDM2B_26808549_Chip-Seq_JURKAT_Human1.09794178
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08965177
73NCOR1_26117541_ChIP-Seq_K562_Human1.07879790
74GATA2_21666600_ChIP-Seq_HMVEC_Human1.06923945
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06405159
76* GATA3_26560356_Chip-Seq_TH2_Human1.05459226
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.02719606
78RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00982325
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.99788486
80ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98917595
81BCL6_27268052_Chip-Seq_Bcells_Human0.97145870
82E2F4_17652178_ChIP-ChIP_JURKAT_Human0.96933628
83IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95625296
84VDR_24787735_ChIP-Seq_THP-1_Human0.95224609
85BCOR_27268052_Chip-Seq_Bcells_Human0.91443827
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91106143
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89385537
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88819240
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88058200
90* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87822031
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87406608
92GATA1_19941826_ChIP-Seq_K562_Human0.87324070
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86370821
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85519594
95* GATA2_19941826_ChIP-Seq_K562_Human0.83367590
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82915885
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82615247
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79686591
99* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79440111
100* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78941065
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.77301690
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.76138948
103SMAD_19615063_ChIP-ChIP_OVARY_Human0.75089194
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74917752
105* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74869114
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74825280
107GATA1_22025678_ChIP-Seq_K562_Human0.73809278
108LXR_22292898_ChIP-Seq_THP-1_Human0.73638757
109* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73194419
110HOXB4_20404135_ChIP-ChIP_EML_Mouse0.70278066
111* SPI1_20517297_ChIP-Seq_HL60_Human0.70249802
112RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.66532751

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology3.65824459
2MP0001835_abnormal_antigen_presentation3.54073519
3MP0000685_abnormal_immune_system3.29988548
4MP0001800_abnormal_humoral_immune3.28683410
5MP0005671_abnormal_response_to3.26439653
6MP0005387_immune_system_phenotype3.15885819
7MP0001790_abnormal_immune_system3.15885819
8MP0003303_peritoneal_inflammation2.99606550
9MP0005000_abnormal_immune_tolerance2.83609179
10MP0002452_abnormal_antigen_presenting2.82260324
11MP0003436_decreased_susceptibility_to2.79035313
12* MP0002420_abnormal_adaptive_immunity2.70235223
13MP0002723_abnormal_immune_serum2.69834608
14* MP0001819_abnormal_immune_cell2.66824631
15MP0002398_abnormal_bone_marrow2.57599342
16MP0002396_abnormal_hematopoietic_system2.56282091
17MP0003300_gastrointestinal_ulcer2.45644412
18MP0005025_abnormal_response_to2.36201677
19MP0009785_altered_susceptibility_to2.33681709
20MP0001873_stomach_inflammation2.33651621
21MP0002419_abnormal_innate_immunity2.31478611
22MP0002405_respiratory_system_inflammati2.30371089
23MP0000716_abnormal_immune_system2.29609805
24MP0002166_altered_tumor_susceptibility2.22668878
25MP0009333_abnormal_splenocyte_physiolog2.15054298
26MP0000689_abnormal_spleen_morphology2.14476841
27MP0002722_abnormal_immune_system2.10356430
28MP0006082_CNS_inflammation2.07731822
29MP0004947_skin_inflammation2.06257927
30MP0005464_abnormal_platelet_physiology2.03034446
31MP0000703_abnormal_thymus_morphology2.01724509
32MP0010155_abnormal_intestine_physiology1.95970045
33MP0002148_abnormal_hypersensitivity_rea1.95465420
34MP0004808_abnormal_hematopoietic_stem1.94049933
35MP0002429_abnormal_blood_cell1.91212815
36MP0009278_abnormal_bone_marrow1.86789754
37MP0004510_myositis1.84402444
38MP0002006_tumorigenesis1.80763368
39MP0003724_increased_susceptibility_to1.76181816
40MP0008260_abnormal_autophagy1.74981766
41MP0001845_abnormal_inflammatory_respons1.73598753
42MP0003866_abnormal_defecation1.70043718
43MP0005451_abnormal_body_composition1.69097402
44MP0000465_gastrointestinal_hemorrhage1.63033357
45MP0001853_heart_inflammation1.62651461
46MP0010352_gastrointestinal_tract_polyps1.59508150
47MP0002933_joint_inflammation1.53379336
48MP0001545_abnormal_hematopoietic_system1.49469537
49MP0005397_hematopoietic_system_phenotyp1.49469537
50MP0004381_abnormal_hair_follicle1.45619584
51MP0005076_abnormal_cell_differentiation1.43119202
52MP0001533_abnormal_skeleton_physiology1.35869108
53MP0000490_abnormal_crypts_of1.31648901
54MP0000858_altered_metastatic_potential1.29983477
55MP0003448_altered_tumor_morphology1.28560382
56MP0005310_abnormal_salivary_gland1.22677742
57MP0004883_abnormal_blood_vessel1.16352248
58MP0008469_abnormal_protein_level1.13297195
59MP0008961_abnormal_basal_metabolism1.12438023
60MP0001851_eye_inflammation1.09235364
61MP0003566_abnormal_cell_adhesion1.08511795
62MP0005023_abnormal_wound_healing1.06312019
63MP0003183_abnormal_peptide_metabolism1.02180574
64MP0002019_abnormal_tumor_incidence1.01800149
65MP0005164_abnormal_response_to1.00636633
66MP0003045_fibrosis1.00288298
67MP0003191_abnormal_cellular_cholesterol0.99324684
68MP0000569_abnormal_digit_pigmentation0.97668295
69MP0003075_altered_response_to0.95694319
70MP0010307_abnormal_tumor_latency0.95573401
71MP0005174_abnormal_tail_pigmentation0.95373990
72MP0003091_abnormal_cell_migration0.95233763
73MP0005058_abnormal_lysosome_morphology0.94499930
74MP0002277_abnormal_respiratory_mucosa0.94413886
75MP0003690_abnormal_glial_cell0.93699447
76MP0003077_abnormal_cell_cycle0.92315835
77MP0002998_abnormal_bone_remodeling0.92228842
78MP0000604_amyloidosis0.91718903
79MP0008057_abnormal_DNA_replication0.89805157
80MP0003656_abnormal_erythrocyte_physiolo0.87263233
81MP0003828_pulmonary_edema0.86402657
82MP0003172_abnormal_lysosome_physiology0.85589591
83MP0000015_abnormal_ear_pigmentation0.80099695
84MP0003453_abnormal_keratinocyte_physiol0.76441082
85MP0003279_aneurysm0.75009044
86MP0004130_abnormal_muscle_cell0.74905018
87MP0008004_abnormal_stomach_pH0.74035886
88MP0000343_altered_response_to0.73164868
89MP0004185_abnormal_adipocyte_glucose0.72516011
90MP0010094_abnormal_chromosome_stability0.72346637
91MP0009840_abnormal_foam_cell0.72336355
92MP0002009_preneoplasia0.70092966
93MP0009765_abnormal_xenobiotic_induced0.69305865
94MP0002132_abnormal_respiratory_system0.69223434
95MP0009763_increased_sensitivity_to0.69170263
96MP0003221_abnormal_cardiomyocyte_apopto0.67185840
97MP0001663_abnormal_digestive_system0.65783922
98MP0000249_abnormal_blood_vessel0.65609312
99MP0005166_decreased_susceptibility_to0.65207869
100MP0002332_abnormal_exercise_endurance0.65048733
101MP0009764_decreased_sensitivity_to0.64977818
102MP0003111_abnormal_nucleus_morphology0.64586905
103MP0005075_abnormal_melanosome_morpholog0.64542756
104MP0005670_abnormal_white_adipose0.64314899
105MP0003705_abnormal_hypodermis_morpholog0.64205009
106MP0008874_decreased_physiological_sensi0.64145257
107MP0008007_abnormal_cellular_replicative0.63293327
108MP0002138_abnormal_hepatobiliary_system0.58486239
109MP0002136_abnormal_kidney_physiology0.58426927
110MP0003795_abnormal_bone_structure0.57741261
111MP0005390_skeleton_phenotype0.57347103
112MP0000350_abnormal_cell_proliferation0.56613766
113MP0005621_abnormal_cell_physiology0.55709379
114MP0000477_abnormal_intestine_morphology0.55521581
115MP0000313_abnormal_cell_death0.54750261
116MP0001986_abnormal_taste_sensitivity0.54474974
117MP0000609_abnormal_liver_physiology0.53049728
118MP0000733_abnormal_muscle_development0.52676406
119MP0003693_abnormal_embryo_hatching0.52164648
120MP0000371_diluted_coat_color0.49494768
121MP0006054_spinal_hemorrhage0.48186021
122MP0005381_digestive/alimentary_phenotyp0.44993522

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.67329982
2Eczematoid dermatitis (HP:0000976)4.52917324
3Recurrent abscess formation (HP:0002722)4.50682510
4Abnormality of T cell number (HP:0011839)4.45434959
5Recurrent fungal infections (HP:0002841)4.40676985
6Recurrent viral infections (HP:0004429)4.38612826
7Recurrent bronchitis (HP:0002837)4.35488328
8IgM deficiency (HP:0002850)4.33731121
9Chronic otitis media (HP:0000389)3.99564262
10Nasal polyposis (HP:0100582)3.92895629
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.84205788
12Recurrent bacterial skin infections (HP:0005406)3.82881292
13Elevated erythrocyte sedimentation rate (HP:0003565)3.78770328
14Pustule (HP:0200039)3.78482883
15Myositis (HP:0100614)3.77969780
16Abnormality of T cells (HP:0002843)3.67239426
17Panhypogammaglobulinemia (HP:0003139)3.62264365
18Agammaglobulinemia (HP:0004432)3.60141535
19Chronic mucocutaneous candidiasis (HP:0002728)3.59022533
20Recurrent cutaneous fungal infections (HP:0011370)3.59022533
21Inflammation of the large intestine (HP:0002037)3.50585373
22Cellulitis (HP:0100658)3.47716787
23Abnormality of the fingertips (HP:0001211)3.46393645
24Abnormality of the nasal mucosa (HP:0000433)3.45162403
25Stomatitis (HP:0010280)3.43534207
26Meningitis (HP:0001287)3.41589886
27Gastrointestinal inflammation (HP:0004386)3.39737072
28Autoimmune thrombocytopenia (HP:0001973)3.38622841
29Spontaneous hematomas (HP:0007420)3.30212855
30Mediastinal lymphadenopathy (HP:0100721)3.30125804
31Colitis (HP:0002583)3.29568632
32Lymphopenia (HP:0001888)3.18420637
33Increased IgM level (HP:0003496)3.11041582
34Recurrent skin infections (HP:0001581)3.09782591
35Abnormality of cells of the lymphoid lineage (HP:0012140)3.07137676
36Vasculitis (HP:0002633)3.05927413
37Keratoconjunctivitis (HP:0001096)3.02214373
38Verrucae (HP:0200043)3.00323510
39Papilloma (HP:0012740)3.00323510
40Obstructive lung disease (HP:0006536)2.94094662
41Chronic obstructive pulmonary disease (HP:0006510)2.94094662
42Urticaria (HP:0001025)2.93785420
43Combined immunodeficiency (HP:0005387)2.87828543
44Recurrent gram-negative bacterial infections (HP:0005420)2.85915221
45Thyroiditis (HP:0100646)2.85791791
46Recurrent sinusitis (HP:0011108)2.84665660
47Severe combined immunodeficiency (HP:0004430)2.81492342
48Optic neuritis (HP:0100653)2.80868488
49Retrobulbar optic neuritis (HP:0100654)2.80868488
50Orchitis (HP:0100796)2.77555470
51Eosinophilia (HP:0001880)2.76989864
52Leukocytosis (HP:0001974)2.75086499
53Abnormality of T cell physiology (HP:0011840)2.74898626
54Increased IgE level (HP:0003212)2.65885828
55Prolonged bleeding time (HP:0003010)2.64936153
56B lymphocytopenia (HP:0010976)2.64914317
57Abnormality of B cell number (HP:0010975)2.64914317
58Chronic diarrhea (HP:0002028)2.63703428
59IgG deficiency (HP:0004315)2.62029462
60Gastrointestinal stroma tumor (HP:0100723)2.60946896
61Abnormality of eosinophils (HP:0001879)2.58592565
62Slow saccadic eye movements (HP:0000514)2.54348931
63Increased density of long bones (HP:0006392)2.49409968
64IgA deficiency (HP:0002720)2.48894632
65Bronchitis (HP:0012387)2.48669735
66Pulmonary infiltrates (HP:0002113)2.45380393
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.44801143
68Hemoptysis (HP:0002105)2.44156993
69Granulocytopenia (HP:0001913)2.43713308
70Hypochromic anemia (HP:0001931)2.43222504
71Chronic sinusitis (HP:0011109)2.42136995
72Emphysema (HP:0002097)2.41592522
73Arterial thrombosis (HP:0004420)2.40703668
74Gingivitis (HP:0000230)2.40384065
75Abnormality of glycolipid metabolism (HP:0010969)2.39384052
76Abnormality of liposaccharide metabolism (HP:0010968)2.39384052
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.39384052
78Periodontitis (HP:0000704)2.38824593
79Encephalitis (HP:0002383)2.37977941
80Abnormality of macrophages (HP:0004311)2.37798663
81Hypergammaglobulinemia (HP:0010702)2.37509704
82Hematochezia (HP:0002573)2.36765969
83Increased cerebral lipofuscin (HP:0011813)2.35735534
84Anorexia (HP:0002039)2.34896613
85Abnormal platelet volume (HP:0011876)2.34416547
86Peritonitis (HP:0002586)2.28504236
87Osteomyelitis (HP:0002754)2.27351304
88Episodic fever (HP:0001954)2.27020994
89Thrombocytosis (HP:0001894)2.22937069
90Chest pain (HP:0100749)2.22703385
91Cerebral aneurysm (HP:0004944)2.22616289
92Lymphoma (HP:0002665)2.21953330
93Epistaxis (HP:0000421)2.19941964
94Hypochromic microcytic anemia (HP:0004840)2.19517046
95Keratitis (HP:0000491)2.14336014
96Gangrene (HP:0100758)2.12531120
97Interstitial pulmonary disease (HP:0006530)2.11175707
98Abnormality of the pleura (HP:0002103)2.10185194
99Petechiae (HP:0000967)2.07796834
100Restrictive lung disease (HP:0002091)2.07603113
101Amyloidosis (HP:0011034)2.07184416
102Skin ulcer (HP:0200042)2.05548603
103Recurrent otitis media (HP:0000403)2.04370881
104Papilledema (HP:0001085)2.03888690
105Microcytic anemia (HP:0001935)2.03429414
106Basal cell carcinoma (HP:0002671)2.02380239
107Autoimmune hemolytic anemia (HP:0001890)2.01961431
108Viral hepatitis (HP:0006562)2.01919105
109Increased serum ferritin (HP:0003281)1.99501954
110Glomerulopathy (HP:0100820)1.98483048
111Increased neuronal autofluorescent lipopigment (HP:0002074)1.98343539
112Keratoconjunctivitis sicca (HP:0001097)1.97967123
113Abnormality of the peritoneum (HP:0002585)1.97821013
114Loss of speech (HP:0002371)1.96976888
115Dysostosis multiplex (HP:0000943)1.96218476
116Joint swelling (HP:0001386)1.93848829
117Sepsis (HP:0100806)1.93182358
118Cheilitis (HP:0100825)1.92992056
119Gingival bleeding (HP:0000225)1.90147237
120Gastrointestinal infarctions (HP:0005244)1.90033721
121Purpura (HP:0000979)1.88096994
122Retinal atrophy (HP:0001105)1.87222906
123Fatigue (HP:0012378)1.86463408
124Pulmonary embolism (HP:0002204)1.86279578
125Aortic aneurysm (HP:0004942)1.85495743
126Impaired platelet aggregation (HP:0003540)1.84776283
127Abnormal platelet function (HP:0011869)1.84776283
128Acute hepatic failure (HP:0006554)1.84624622
129Recurrent pneumonia (HP:0006532)1.84599213
130Increased mean platelet volume (HP:0011877)1.81791680
131Recurrent lower respiratory tract infections (HP:0002783)1.81298541

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.77648544
2TXK3.79616251
3PRPF4B2.96490273
4TYK22.68751116
5JAK32.60279134
6GRK62.49921618
7ZAP702.46007771
8MAP3K102.43186865
9ITK2.41593583
10EEF2K2.24775420
11CDK122.19082986
12JAK11.98262824
13* STK101.97643487
14MAP3K141.90516277
15IKBKE1.88548451
16BLK1.87587819
17FGFR41.83203561
18BTK1.81876361
19CSK1.76372450
20TGFBR21.74558784
21TBK11.65180604
22CSF1R1.63523969
23LCK1.62817364
24HCK1.60132342
25MAP3K31.58951035
26PKN21.55921259
27IRAK41.54527246
28SYK1.54527124
29LRRK21.53127185
30TEC1.47343557
31FGFR31.46776182
32KIT1.45759645
33SIK21.45459507
34TRIB31.43257978
35NLK1.42556929
36MAP3K131.39220088
37MAP3K111.38859863
38ERN11.37927844
39EPHB11.32147734
40CLK11.27293022
41MAP2K31.26903150
42TTN1.22252151
43IKBKB1.21103466
44FES1.18150106
45RIPK41.16794927
46MAP3K11.13227601
47TAOK21.12208851
48RPS6KA41.11819042
49IRAK31.05545271
50MST41.02306193
51PRKCH1.02297438
52BMPR20.93689328
53CDK40.92459870
54MATK0.92400170
55CHUK0.90652028
56NEK20.90643897
57LYN0.90550392
58PTK2B0.89835106
59PRKCQ0.87966994
60JAK20.86665486
61YES10.85033854
62CDC42BPA0.82817300
63PTK60.82287786
64STK40.81893331
65IRAK10.80643075
66BRD40.80144428
67KSR20.79714817
68CAMK1D0.78348478
69SMG10.75776959
70* PIM10.75404085
71TAOK30.74757075
72CAMKK20.69543322
73TRPM70.67674758
74PDPK10.67081901
75CDK90.66544018
76TNK20.66275679
77GRK70.66043515
78MELK0.65563346
79ALK0.65498910
80SIK30.65440685
81CDK60.64263787
82KDR0.64164490
83MAP3K70.64066266
84RIPK10.62684792
85CAMK1G0.62516144
86FLT30.60516043
87IRAK20.60486559
88PIK3CG0.59888723
89CAMKK10.58645964
90PDK10.58472979
91MAP3K80.56629395
92PRKD20.55814595
93DMPK0.54432347
94TESK20.54079827
95PDGFRB0.52428562
96MAP2K20.48629358
97FGR0.46658400
98TAOK10.42687787
99RPS6KA60.42083198
100MAPK40.41426052
101MARK20.40903071
102HIPK20.39857237
103MAP3K60.39661823
104MAP3K50.39081965
105MAPKAPK20.38753363
106MAPK70.38526976
107MOS0.38272726
108SIK10.38205248
109STK240.38102326
110EPHA30.37979565
111CDK190.37170090
112DYRK1B0.36944358
113RET0.36825464
114ABL10.36768165
115RPS6KB20.36767640
116STK380.35676816
117MAPK120.35354331
118NME20.35339791
119EGFR0.35301883
120MAPK110.34375972
121INSR0.34192693
122FYN0.33223404
123* MARK30.33145293
124MAP2K60.32829381
125RPS6KL10.32075695
126RPS6KC10.32075695
127STK30.31299809
128SGK30.28309964
129PAK40.25955939

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.01489087
2B cell receptor signaling pathway_Homo sapiens_hsa046622.74673092
3T cell receptor signaling pathway_Homo sapiens_hsa046602.62306519
4Leishmaniasis_Homo sapiens_hsa051402.55004138
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.46527181
6Osteoclast differentiation_Homo sapiens_hsa043802.45552703
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.45024923
8Measles_Homo sapiens_hsa051622.32864849
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.28425802
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.22038869
11Hematopoietic cell lineage_Homo sapiens_hsa046402.16451536
12Antigen processing and presentation_Homo sapiens_hsa046122.11418201
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90283656
14Type I diabetes mellitus_Homo sapiens_hsa049401.80558728
15Staphylococcus aureus infection_Homo sapiens_hsa051501.73138683
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.62903705
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.62454052
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59483793
19Toxoplasmosis_Homo sapiens_hsa051451.58996022
20Herpes simplex infection_Homo sapiens_hsa051681.58176257
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54019937
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51848320
23Viral myocarditis_Homo sapiens_hsa054161.48336249
24Acute myeloid leukemia_Homo sapiens_hsa052211.48213617
25Chemokine signaling pathway_Homo sapiens_hsa040621.46702692
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44792913
27Graft-versus-host disease_Homo sapiens_hsa053321.44487970
28Hepatitis B_Homo sapiens_hsa051611.39491532
29Chronic myeloid leukemia_Homo sapiens_hsa052201.38868212
30Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38447005
31Shigellosis_Homo sapiens_hsa051311.36798971
32Influenza A_Homo sapiens_hsa051641.36362151
33Tuberculosis_Homo sapiens_hsa051521.34132463
34Allograft rejection_Homo sapiens_hsa053301.32959516
35TNF signaling pathway_Homo sapiens_hsa046681.26339974
36Pancreatic cancer_Homo sapiens_hsa052121.24231944
37Apoptosis_Homo sapiens_hsa042101.23717051
38Platelet activation_Homo sapiens_hsa046111.22780565
39Legionellosis_Homo sapiens_hsa051341.22156303
40Malaria_Homo sapiens_hsa051441.22056354
41Pertussis_Homo sapiens_hsa051331.16504723
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14925180
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13025157
44Phagosome_Homo sapiens_hsa041451.12468548
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11644333
46Epstein-Barr virus infection_Homo sapiens_hsa051691.05069082
47HTLV-I infection_Homo sapiens_hsa051661.04468653
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02103941
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98672200
50Salmonella infection_Homo sapiens_hsa051320.97681763
51Viral carcinogenesis_Homo sapiens_hsa052030.97547996
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94801963
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93708766
54Colorectal cancer_Homo sapiens_hsa052100.93036048
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.92824958
56Small cell lung cancer_Homo sapiens_hsa052220.88255660
57Other glycan degradation_Homo sapiens_hsa005110.87785905
58Hepatitis C_Homo sapiens_hsa051600.87544854
59VEGF signaling pathway_Homo sapiens_hsa043700.87481844
60Non-small cell lung cancer_Homo sapiens_hsa052230.86528719
61Notch signaling pathway_Homo sapiens_hsa043300.80603895
62Autoimmune thyroid disease_Homo sapiens_hsa053200.78928295
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77536382
64Non-homologous end-joining_Homo sapiens_hsa034500.76490594
65Prolactin signaling pathway_Homo sapiens_hsa049170.76107278
66Asthma_Homo sapiens_hsa053100.73614901
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72716627
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72149932
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71881095
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.70388769
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70169938
72p53 signaling pathway_Homo sapiens_hsa041150.64197964
73FoxO signaling pathway_Homo sapiens_hsa040680.63212101
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61376844
75Lysine degradation_Homo sapiens_hsa003100.61223479
76Inositol phosphate metabolism_Homo sapiens_hsa005620.60139144
77Endocytosis_Homo sapiens_hsa041440.60087152
78MicroRNAs in cancer_Homo sapiens_hsa052060.57517873
79Renal cell carcinoma_Homo sapiens_hsa052110.57496084
80mTOR signaling pathway_Homo sapiens_hsa041500.57483848
81Insulin resistance_Homo sapiens_hsa049310.55804783
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.54489187
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54269074
84Choline metabolism in cancer_Homo sapiens_hsa052310.54129939
85HIF-1 signaling pathway_Homo sapiens_hsa040660.53809788
86Prostate cancer_Homo sapiens_hsa052150.52944413
87Proteoglycans in cancer_Homo sapiens_hsa052050.52941333
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52780800
89Adherens junction_Homo sapiens_hsa045200.52379544
90GnRH signaling pathway_Homo sapiens_hsa049120.51720991
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50526740
92MAPK signaling pathway_Homo sapiens_hsa040100.48175866
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47860852
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46370056
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46074542
96African trypanosomiasis_Homo sapiens_hsa051430.45617510
97Lysosome_Homo sapiens_hsa041420.44808724
98Base excision repair_Homo sapiens_hsa034100.44188628
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.43927733
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42967674
101Type II diabetes mellitus_Homo sapiens_hsa049300.42729288
102Endometrial cancer_Homo sapiens_hsa052130.42480741
103Rap1 signaling pathway_Homo sapiens_hsa040150.41873568
104Rheumatoid arthritis_Homo sapiens_hsa053230.41569055
105ErbB signaling pathway_Homo sapiens_hsa040120.41004141
106Dorso-ventral axis formation_Homo sapiens_hsa043200.40939964
107Pathways in cancer_Homo sapiens_hsa052000.40076789
108Amoebiasis_Homo sapiens_hsa051460.39408983
109Focal adhesion_Homo sapiens_hsa045100.38532462
110Cell cycle_Homo sapiens_hsa041100.38114231
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.37923370
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.35472790
113Spliceosome_Homo sapiens_hsa030400.35216224
114Glioma_Homo sapiens_hsa052140.33898539
115Bladder cancer_Homo sapiens_hsa052190.31995399

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