STK11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1oxygen transport (GO:0015671)4.16785062
2positive regulation of histone deacetylation (GO:0031065)4.04509987
3maternal placenta development (GO:0001893)3.89224973
4protoporphyrinogen IX metabolic process (GO:0046501)3.82589335
5positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.81925173
6lysine metabolic process (GO:0006553)3.80368425
7lysine catabolic process (GO:0006554)3.80368425
8gas transport (GO:0015669)3.75403737
9modulation by virus of host process (GO:0019054)3.71859074
10positive regulation of triglyceride biosynthetic process (GO:0010867)3.68168560
11regulation of cholesterol homeostasis (GO:2000188)3.67385937
12cysteine metabolic process (GO:0006534)3.63173823
13modulation by symbiont of host cellular process (GO:0044068)3.62292101
142-oxoglutarate metabolic process (GO:0006103)3.61334112
15regulation of fatty acid beta-oxidation (GO:0031998)3.59661572
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.56018210
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56018210
18cellular response to virus (GO:0098586)3.53517015
19negative regulation of cell size (GO:0045792)3.49062132
20positive regulation of fatty acid beta-oxidation (GO:0032000)3.40054839
21negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38278500
22apoptotic process involved in morphogenesis (GO:0060561)3.36209929
23valine metabolic process (GO:0006573)3.33182051
24L-phenylalanine metabolic process (GO:0006558)3.28873582
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.28873582
264-hydroxyproline metabolic process (GO:0019471)3.28812909
27intracellular estrogen receptor signaling pathway (GO:0030520)3.23687286
28antigen processing and presentation of endogenous antigen (GO:0019883)3.19578508
29positive regulation of triglyceride metabolic process (GO:0090208)3.18282056
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.17153346
31urea cycle (GO:0000050)3.17060771
32urea metabolic process (GO:0019627)3.17060771
33glycine metabolic process (GO:0006544)3.16994717
34protein localization to endosome (GO:0036010)3.16375978
35negative regulation of cell killing (GO:0031342)3.16030657
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.16030657
37regulation of response to osmotic stress (GO:0047484)3.15595978
38low-density lipoprotein particle clearance (GO:0034383)3.13263430
39viral transcription (GO:0019083)3.11278685
40erythrocyte maturation (GO:0043249)3.11205582
41kynurenine metabolic process (GO:0070189)3.09264448
42fatty acid transmembrane transport (GO:1902001)3.08639278
43serine family amino acid catabolic process (GO:0009071)3.08582417
44peptidyl-lysine dimethylation (GO:0018027)3.07677629
45L-phenylalanine catabolic process (GO:0006559)3.06720246
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.06720246
47carnitine shuttle (GO:0006853)3.01731072
48negative regulation of myotube differentiation (GO:0010832)3.01428318
49regulation of chromatin binding (GO:0035561)3.01121063
50regulation of gamma-delta T cell differentiation (GO:0045586)3.00061264
51regulation of cholesterol storage (GO:0010885)2.99215560
52modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.97859420
53positive regulation by organism of defense response of other organism involved in symbiotic interact2.97859420
54modulation by symbiont of host immune response (GO:0052553)2.97859420
55positive regulation by symbiont of host defense response (GO:0052509)2.97859420
56modulation by symbiont of host defense response (GO:0052031)2.97859420
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.97859420
58regulation of triglyceride biosynthetic process (GO:0010866)2.97782698
59response to muramyl dipeptide (GO:0032495)2.96207933
60protoporphyrinogen IX biosynthetic process (GO:0006782)2.95465440
61regulation of early endosome to late endosome transport (GO:2000641)2.95022048
62oxaloacetate metabolic process (GO:0006107)2.94788000
63alpha-linolenic acid metabolic process (GO:0036109)2.92873837
64regulation of mammary gland epithelial cell proliferation (GO:0033599)2.91806663
65sulfur amino acid catabolic process (GO:0000098)2.91251798
66positive regulation of Cdc42 GTPase activity (GO:0043089)2.91182515
67translational termination (GO:0006415)2.90249958
68fat-soluble vitamin biosynthetic process (GO:0042362)2.89007769
69positive regulation of lipid storage (GO:0010884)2.88960224
70amino-acid betaine metabolic process (GO:0006577)2.88372691
71peptidyl-glutamic acid carboxylation (GO:0017187)2.88041057
72protein carboxylation (GO:0018214)2.88041057
73adherens junction assembly (GO:0034333)2.87692027
74positive regulation of gamma-delta T cell activation (GO:0046645)2.87266317
75nitrogen cycle metabolic process (GO:0071941)2.86854366
76positive regulation of protein deacetylation (GO:0090312)2.85329910
77positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.85219592
78negative regulation of fibrinolysis (GO:0051918)2.84281246
79regulation of fatty acid oxidation (GO:0046320)2.84202468
80fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.83962159
81response to peptidoglycan (GO:0032494)2.82421639
82glyoxylate metabolic process (GO:0046487)2.81998144
83phospholipid efflux (GO:0033700)2.81946257
84pentose-phosphate shunt (GO:0006098)2.81031295
85focal adhesion assembly (GO:0048041)2.78495025
86cell-substrate adherens junction assembly (GO:0007045)2.78495025
87regulation of ARF GTPase activity (GO:0032312)2.78171909
88negative regulation of cholesterol transport (GO:0032375)2.78048035
89negative regulation of sterol transport (GO:0032372)2.78048035
90detection of bacterium (GO:0016045)2.78037116
91negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.76873419
92negative regulation of erythrocyte differentiation (GO:0045647)2.76726409
93regulation of triglyceride catabolic process (GO:0010896)2.76017454
94erythrocyte development (GO:0048821)2.75245228
95cytoskeletal anchoring at plasma membrane (GO:0007016)2.74070273
96proline biosynthetic process (GO:0006561)2.73539737
97aspartate family amino acid catabolic process (GO:0009068)2.71930733
98activation of MAPKKK activity (GO:0000185)2.71827972
99activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.69843471
100plasma lipoprotein particle assembly (GO:0034377)2.69826391
101regulation of type I interferon-mediated signaling pathway (GO:0060338)2.69234658
102protein-lipid complex assembly (GO:0065005)2.69221671
103positive regulation of nuclease activity (GO:0032075)2.67820079
104aromatic amino acid family catabolic process (GO:0009074)2.67420827
105RNA stabilization (GO:0043489)2.67296460
106mRNA stabilization (GO:0048255)2.67296460
107homocysteine metabolic process (GO:0050667)2.66640027
108detection of other organism (GO:0098543)2.66554696
109tricarboxylic acid metabolic process (GO:0072350)2.66459049
110heterochromatin organization (GO:0070828)2.66418096
111negative regulation of viral release from host cell (GO:1902187)2.66240630
112regulation of gamma-delta T cell activation (GO:0046643)2.66034389
113hemoglobin metabolic process (GO:0020027)2.65080256
114plasma lipoprotein particle clearance (GO:0034381)2.64687227
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.64027596
116regulation of glucose import in response to insulin stimulus (GO:2001273)2.63522960
117GDP-mannose metabolic process (GO:0019673)2.62900037
118negative regulation of fatty acid transport (GO:2000192)2.62148149
119mannose metabolic process (GO:0006013)2.61384564
1203-UTR-mediated mRNA stabilization (GO:0070935)2.60395020
121regulation of sequestering of triglyceride (GO:0010889)2.60278747
122translational elongation (GO:0006414)2.59735679
123fatty acid beta-oxidation (GO:0006635)2.58818173
124serine family amino acid metabolic process (GO:0009069)2.58733995
125regulation of necroptotic process (GO:0060544)2.58456243
126acetyl-CoA metabolic process (GO:0006084)2.56900612
127protein targeting to plasma membrane (GO:0072661)2.56891144
128embryonic process involved in female pregnancy (GO:0060136)2.56381601
129regulation of triglyceride metabolic process (GO:0090207)2.55999262
130regulation of leukocyte degranulation (GO:0043300)2.55845164
131planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55573146
132positive regulation of myotube differentiation (GO:0010831)2.54824956
133response to laminar fluid shear stress (GO:0034616)2.54164464
134carnitine transmembrane transport (GO:1902603)2.53886973
135regulation of hippo signaling (GO:0035330)2.53724636
136* thymic T cell selection (GO:0045061)2.53645099
137fatty acid oxidation (GO:0019395)2.53320638
138positive regulation of lipid catabolic process (GO:0050996)2.53036594
139activation of JUN kinase activity (GO:0007257)2.51473741
140negative regulation of nucleotide catabolic process (GO:0030812)2.51376157
141complement activation, alternative pathway (GO:0006957)2.51173732
142positive regulation of fatty acid oxidation (GO:0046321)2.50661067
143antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49786418
144amino-acid betaine transport (GO:0015838)2.49348266
145carnitine transport (GO:0015879)2.49348266
146ethanol oxidation (GO:0006069)2.48974288
147megakaryocyte development (GO:0035855)2.48764878
148negative regulation of fatty acid metabolic process (GO:0045922)2.48720980
149positive regulation of Rap GTPase activity (GO:0032854)2.48184564
150protein hydroxylation (GO:0018126)2.46950778
151high-density lipoprotein particle remodeling (GO:0034375)2.46834012
152protein retention in ER lumen (GO:0006621)2.46693483
153barbed-end actin filament capping (GO:0051016)2.46507729
154cellular modified amino acid catabolic process (GO:0042219)2.46455976
155negative regulation of lipid transport (GO:0032369)2.46436226
156negative regulation of heart growth (GO:0061117)2.46072095
157negative regulation of cardiac muscle tissue growth (GO:0055022)2.46072095
158modulation by virus of host morphology or physiology (GO:0019048)2.45960881
159lipid oxidation (GO:0034440)2.45713205
160negative regulation of necroptotic process (GO:0060546)2.45702079
161negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.45231977
162negative regulation of toll-like receptor signaling pathway (GO:0034122)2.45114918
163negative regulation of fatty acid biosynthetic process (GO:0045717)2.44889055
164ribosomal small subunit assembly (GO:0000028)2.44662099
165activation of Rac GTPase activity (GO:0032863)2.44592753
166indolalkylamine catabolic process (GO:0046218)2.44563116
167tryptophan catabolic process (GO:0006569)2.44563116
168epithelial cell differentiation involved in prostate gland development (GO:0060742)2.43965651
169regulation of necrotic cell death (GO:0010939)2.43366811
170adenosine receptor signaling pathway (GO:0001973)2.42846899
171semaphorin-plexin signaling pathway (GO:0071526)2.42283811
172porphyrin-containing compound biosynthetic process (GO:0006779)2.42133122
173histone H4 deacetylation (GO:0070933)2.41609445
174negative regulation of striated muscle cell differentiation (GO:0051154)2.40230293
175negative regulation of glial cell proliferation (GO:0060253)2.38900739
176stress fiber assembly (GO:0043149)2.38432927
177regulation of myeloid leukocyte mediated immunity (GO:0002886)2.37876863
178NIK/NF-kappaB signaling (GO:0038061)2.35158626
179positive regulation of receptor recycling (GO:0001921)2.33254062
180macrophage activation involved in immune response (GO:0002281)2.32374315
181regulation of mast cell degranulation (GO:0043304)2.31527535
182regulation of extracellular matrix disassembly (GO:0010715)2.30139946
183germinal center formation (GO:0002467)2.29665763
184negative regulation of granulocyte differentiation (GO:0030853)2.29609290
185negative regulation of skeletal muscle tissue development (GO:0048642)2.29139467
186UV protection (GO:0009650)2.28477239
187positive regulation of protein dephosphorylation (GO:0035307)2.28335426

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.19627177
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.42610349
3MYC_22102868_ChIP-Seq_BL_Human3.35288770
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.06739345
5E2F7_22180533_ChIP-Seq_HELA_Human3.00995145
6* RXR_22158963_ChIP-Seq_LIVER_Mouse2.97191228
7* FOXM1_23109430_ChIP-Seq_U2OS_Human2.77320138
8* VDR_21846776_ChIP-Seq_THP-1_Human2.73940482
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58877403
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.48919646
11ZNF263_19887448_ChIP-Seq_K562_Human2.47896495
12STAT6_21828071_ChIP-Seq_BEAS2B_Human2.36176545
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.32203900
14* TCF7_22412390_ChIP-Seq_EML_Mouse2.26891823
15* LXR_22158963_ChIP-Seq_LIVER_Mouse2.23918352
16* KDM2B_26808549_Chip-Seq_DND41_Human2.22304758
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.20472951
18EGR1_19374776_ChIP-ChIP_THP-1_Human2.18788750
19* ELK3_25401928_ChIP-Seq_HUVEC_Human2.06552041
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01285986
21LXR_22292898_ChIP-Seq_THP-1_Human1.96735928
22* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93991767
23MAF_26560356_Chip-Seq_TH1_Human1.85862420
24* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85159171
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81905248
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78249182
27RACK7_27058665_Chip-Seq_MCF-7_Human1.67693445
28UTX_26944678_Chip-Seq_JUKART_Human1.67130494
29* VDR_24763502_ChIP-Seq_THP-1_Human1.66839255
30CLOCK_20551151_ChIP-Seq_293T_Human1.61911361
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.61595755
32FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58764910
33* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58493459
34* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54453829
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52476560
36* ERG_21242973_ChIP-ChIP_JURKAT_Human1.48390160
37ATF3_27146783_Chip-Seq_COLON_Human1.48312379
38* SMC4_20622854_ChIP-Seq_HELA_Human1.47574270
39MAF_26560356_Chip-Seq_TH2_Human1.47179783
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.46603958
41E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42916565
42STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42574487
43TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42436497
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40509255
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38457956
46* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.37272521
47* KDM2B_26808549_Chip-Seq_JURKAT_Human1.34523436
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.33306887
49* GATA1_19941827_ChIP-Seq_MEL_Mouse1.31071749
50* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29948862
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29442137
52DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29420183
53* P68_20966046_ChIP-Seq_HELA_Human1.29072171
54* CTCF_27219007_Chip-Seq_Bcells_Human1.28677592
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.27992568
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27936151
57NCOR1_26117541_ChIP-Seq_K562_Human1.27784470
58SCL_19346495_ChIP-Seq_HPC-7_Human1.27761816
59CIITA_25753668_ChIP-Seq_RAJI_Human1.27587516
60DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25820692
61* GATA1_19941826_ChIP-Seq_K562_Human1.25102808
62* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24744588
63* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22924647
64THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22755768
65* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.22484680
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.21858824
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20002334
68* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19558277
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19105568
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18926653
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18894289
72* BCOR_27268052_Chip-Seq_Bcells_Human1.18544759
73* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17838457
74* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17591524
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.16686346
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16368113
77CREB1_26743006_Chip-Seq_LNCaP_Human1.15968890
78CTCF_21964334_Chip-Seq_Bcells_Human1.15637802
79TP53_22127205_ChIP-Seq_IMR90_Human1.15574196
80KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14347918
81CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14026652
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13730805
83GATA1_22025678_ChIP-Seq_K562_Human1.13253872
84* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12796922
85* ELF1_20517297_ChIP-Seq_JURKAT_Human1.12760111
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.12079443
87MYB_21317192_ChIP-Seq_ERMYB_Mouse1.10896088
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09894189
89TBX20_22328084_ChIP-Seq_HEART_Mouse1.09693446
90TBX20_22080862_ChIP-Seq_HEART_Mouse1.09693446
91SA1_27219007_Chip-Seq_Bcells_Human1.09162290
92CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.08752615
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08641096
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07838405
95* MYB_26560356_Chip-Seq_TH1_Human1.07354165
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07095757
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06855173
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06844796
99* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06255537
100E2F1_20622854_ChIP-Seq_HELA_Human1.05129221
101* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04779658
102* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04196264
103* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03593735
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03564333
105* BCL6_27268052_Chip-Seq_Bcells_Human1.03451261
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03324197
107MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02467562
108* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02434797
109* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.02185815
110BP1_19119308_ChIP-ChIP_Hs578T_Human1.00925433
111MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00900095
112* RARA_24833708_ChIP-Seq_LIVER_Mouse1.00578715
113SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00264237
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99888672
115* KDM2B_26808549_Chip-Seq_K562_Human0.99457646
116SPI1_23127762_ChIP-Seq_K562_Human0.99394008
117STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.97791184
118* RUNX1_27514584_Chip-Seq_MCF-7_Human0.97528091
119CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96393790
120* GATA6_25053715_ChIP-Seq_YYC3_Human0.96295802
121* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96285971
122* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95337721
123* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95145416
124ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94251377
125EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93806232
126ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93751074
127* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93030910
128ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92905419
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.92524172
130* KDM5A_27292631_Chip-Seq_BREAST_Human0.90508235
131MYC_19079543_ChIP-ChIP_MESCs_Mouse0.90411841
132XRN2_22483619_ChIP-Seq_HELA_Human0.89689233
133* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89276862
134PHF8_20622854_ChIP-Seq_HELA_Human0.89243941
135MYB_26560356_Chip-Seq_TH2_Human0.89157885
136TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88071829

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.54833749
2MP0003646_muscle_fatigue3.34532379
3MP0005360_urolithiasis3.28776992
4MP0003705_abnormal_hypodermis_morpholog3.14898763
5MP0005058_abnormal_lysosome_morphology2.73534252
6MP0009840_abnormal_foam_cell2.70754533
7MP0005365_abnormal_bile_salt2.69468358
8MP0005083_abnormal_biliary_tract2.61961937
9MP0003172_abnormal_lysosome_physiology2.49641266
10MP0005085_abnormal_gallbladder_physiolo2.36695271
11MP0004858_abnormal_nervous_system2.28364851
12MP0008260_abnormal_autophagy2.22502166
13MP0010329_abnormal_lipoprotein_level2.13607780
14MP0003191_abnormal_cellular_cholesterol2.09458451
15MP0004185_abnormal_adipocyte_glucose2.06948066
16MP0010234_abnormal_vibrissa_follicle1.93522731
17MP0008961_abnormal_basal_metabolism1.91667609
18MP0000678_abnormal_parathyroid_gland1.87493974
19MP0002837_dystrophic_cardiac_calcinosis1.84908450
20MP0003252_abnormal_bile_duct1.84546859
21MP0003300_gastrointestinal_ulcer1.80880159
22* MP0005076_abnormal_cell_differentiation1.76588642
23MP0005409_darkened_coat_color1.76558923
24MP0005666_abnormal_adipose_tissue1.71717542
25MP0003763_abnormal_thymus_physiology1.71671179
26MP0000609_abnormal_liver_physiology1.70026164
27MP0003656_abnormal_erythrocyte_physiolo1.69209335
28MP0004147_increased_porphyrin_level1.69044112
29MP0009333_abnormal_splenocyte_physiolog1.64299580
30MP0002249_abnormal_larynx_morphology1.61131552
31MP0000751_myopathy1.56365289
32MP0003566_abnormal_cell_adhesion1.54805404
33* MP0003303_peritoneal_inflammation1.51223392
34MP0004087_abnormal_muscle_fiber1.50709334
35MP0001873_stomach_inflammation1.50706569
36MP0002138_abnormal_hepatobiliary_system1.49330096
37MP0005330_cardiomyopathy1.45503997
38* MP0004130_abnormal_muscle_cell1.42554928
39* MP0005025_abnormal_response_to1.41761454
40MP0002877_abnormal_melanocyte_morpholog1.41335008
41MP0000750_abnormal_muscle_regeneration1.40543776
42MP0002396_abnormal_hematopoietic_system1.40533316
43MP0000685_abnormal_immune_system1.40369434
44MP0001666_abnormal_nutrient_absorption1.38541577
45MP0004036_abnormal_muscle_relaxation1.36754848
46MP0008875_abnormal_xenobiotic_pharmacok1.35029550
47MP0003329_amyloid_beta_deposits1.33446774
48MP0010630_abnormal_cardiac_muscle1.32669749
49MP0002419_abnormal_innate_immunity1.31468049
50MP0000749_muscle_degeneration1.30454886
51MP0010352_gastrointestinal_tract_polyps1.28540225
52MP0003091_abnormal_cell_migration1.24566624
53MP0002269_muscular_atrophy1.23493666
54MP0003806_abnormal_nucleotide_metabolis1.23115042
55MP0005375_adipose_tissue_phenotype1.21900358
56MP0005000_abnormal_immune_tolerance1.20091245
57MP0004510_myositis1.19862420
58MP0010155_abnormal_intestine_physiology1.19123033
59MP0004084_abnormal_cardiac_muscle1.18342359
60MP0004233_abnormal_muscle_weight1.17331708
61MP0005319_abnormal_enzyme/_coenzyme1.17082214
62MP0003279_aneurysm1.16678872
63MP0002118_abnormal_lipid_homeostasis1.15678038
64MP0002420_abnormal_adaptive_immunity1.13725734
65MP0003436_decreased_susceptibility_to1.13384482
66MP0001819_abnormal_immune_cell1.13181622
67MP0004381_abnormal_hair_follicle1.08960019
68MP0000490_abnormal_crypts_of1.08911087
69MP0005332_abnormal_amino_acid1.08054204
70* MP0000858_altered_metastatic_potential1.07585651
71MP0005670_abnormal_white_adipose1.07393247
72MP0001348_abnormal_lacrimal_gland1.06691903
73MP0010307_abnormal_tumor_latency1.05893312
74MP0001849_ear_inflammation1.05806395
75MP0000733_abnormal_muscle_development1.05220197
76MP0003828_pulmonary_edema1.04680792
77MP0002106_abnormal_muscle_physiology1.04656269
78MP0005464_abnormal_platelet_physiology1.04634608
79* MP0002429_abnormal_blood_cell1.03982516
80MP0002723_abnormal_immune_serum1.03623403
81MP0002796_impaired_skin_barrier1.02695114
82MP0002998_abnormal_bone_remodeling1.02607435
83* MP0001545_abnormal_hematopoietic_system1.02585162
84* MP0005397_hematopoietic_system_phenotyp1.02585162
85MP0001533_abnormal_skeleton_physiology1.01862508
86MP0000747_muscle_weakness1.01662302
87* MP0009931_abnormal_skin_appearance1.00784378
88* MP0005220_abnormal_exocrine_pancreas1.00624785
89* MP0009278_abnormal_bone_marrow0.99543849
90* MP0000598_abnormal_liver_morphology0.99126218
91* MP0000716_abnormal_immune_system0.98755784
92MP0003693_abnormal_embryo_hatching0.98246843
93MP0002452_abnormal_antigen_presenting0.98183665
94MP0005451_abnormal_body_composition0.95953327
95MP0003866_abnormal_defecation0.95839731
96MP0002089_abnormal_postnatal_growth/wei0.95687897
97MP0002971_abnormal_brown_adipose0.95229694
98MP0001835_abnormal_antigen_presentation0.95136647
99MP0008995_early_reproductive_senescence0.94715294
100MP0003221_abnormal_cardiomyocyte_apopto0.93233647
101* MP0006036_abnormal_mitochondrial_physio0.93205401
102MP0000537_abnormal_urethra_morphology0.93047778
103MP0009643_abnormal_urine_homeostasis0.91283193
104MP0000759_abnormal_skeletal_muscle0.90543690
105MP0005501_abnormal_skin_physiology0.90482872
106MP0002970_abnormal_white_adipose0.88489057
107MP0001730_embryonic_growth_arrest0.87381455
108MP0008775_abnormal_heart_ventricle0.87173287
109MP0002132_abnormal_respiratory_system0.86883554
110MP0002933_joint_inflammation0.86468821
111MP0000015_abnormal_ear_pigmentation0.86337982
112MP0000681_abnormal_thyroid_gland0.86168897
113MP0009115_abnormal_fat_cell0.85179456
114MP0003879_abnormal_hair_cell0.85120687
115MP0005387_immune_system_phenotype0.83829675
116MP0001790_abnormal_immune_system0.83829675
117MP0001800_abnormal_humoral_immune0.82928249
118MP0001958_emphysema0.81644666
119MP0004947_skin_inflammation0.80628064
120MP0002166_altered_tumor_susceptibility0.80412264
121MP0009672_abnormal_birth_weight0.80406995
122MP0000604_amyloidosis0.79414380
123* MP0003111_abnormal_nucleus_morphology0.78900738
124MP0000465_gastrointestinal_hemorrhage0.78536985
125MP0002332_abnormal_exercise_endurance0.77973991
126* MP0002722_abnormal_immune_system0.77478132
127* MP0002088_abnormal_embryonic_growth/wei0.77455299
128MP0001544_abnormal_cardiovascular_syste0.76954440
129MP0005385_cardiovascular_system_phenoty0.76954440
130* MP0003984_embryonic_growth_retardation0.76827527
131MP0005334_abnormal_fat_pad0.75362491
132MP0003567_abnormal_fetal_cardiomyocyte0.74885286
133MP0001727_abnormal_embryo_implantation0.74738240
134* MP0004808_abnormal_hematopoietic_stem0.73935967
135MP0008438_abnormal_cutaneous_collagen0.73916426
136MP0003453_abnormal_keratinocyte_physiol0.73584864
137MP0002405_respiratory_system_inflammati0.72810633
138* MP0002398_abnormal_bone_marrow0.72077840
139MP0003045_fibrosis0.71071050
140MP0005377_hearing/vestibular/ear_phenot0.71064815
141MP0003878_abnormal_ear_physiology0.71064815
142* MP0000689_abnormal_spleen_morphology0.70052340
143* MP0002019_abnormal_tumor_incidence0.69469445
144* MP0002078_abnormal_glucose_homeostasis0.68793379
145* MP0002086_abnormal_extraembryonic_tissu0.68675850
146MP0004197_abnormal_fetal_growth/weight/0.68410195
147* MP0000703_abnormal_thymus_morphology0.68357276
148MP0000003_abnormal_adipose_tissue0.68338643
149MP0008469_abnormal_protein_level0.68287111
150MP0008874_decreased_physiological_sensi0.67768698
151MP0001661_extended_life_span0.67548061
152MP0004264_abnormal_extraembryonic_tissu0.67185223

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.82686393
2Abnormality of the heme biosynthetic pathway (HP:0010472)3.52831117
3Increased connective tissue (HP:0009025)3.30795356
4Polycythemia (HP:0001901)3.30508731
5Ulnar bowing (HP:0003031)3.26504727
6Eczematoid dermatitis (HP:0000976)3.09829986
7Xanthomatosis (HP:0000991)3.01027141
8Ventricular tachycardia (HP:0004756)2.92834591
9Myoglobinuria (HP:0002913)2.88421109
10Difficulty climbing stairs (HP:0003551)2.85490097
11Reticulocytosis (HP:0001923)2.85313444
12Obstructive sleep apnea (HP:0002870)2.82547980
13Sudden death (HP:0001699)2.80346111
14Muscle fiber splitting (HP:0003555)2.78921937
15Hyperacusis (HP:0010780)2.76197127
16Hyporeflexia of lower limbs (HP:0002600)2.74016744
17Thin bony cortex (HP:0002753)2.72336599
18Hemorrhage of the eye (HP:0011885)2.70653842
19Right ventricular cardiomyopathy (HP:0011663)2.64845048
20Abnormality of monocarboxylic acid metabolism (HP:0010996)2.63705404
21Ketosis (HP:0001946)2.60494534
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.60241145
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.60045816
24Myocardial infarction (HP:0001658)2.59808681
25Exercise-induced myalgia (HP:0003738)2.55046248
26Poikilocytosis (HP:0004447)2.54930734
27Stridor (HP:0010307)2.54363098
28Distal lower limb muscle weakness (HP:0009053)2.52793698
29Distal lower limb amyotrophy (HP:0008944)2.49967322
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.47313180
31Difficulty running (HP:0009046)2.45219481
32Hyperglycinuria (HP:0003108)2.43390326
33Cerebral aneurysm (HP:0004944)2.41695620
34Complement deficiency (HP:0004431)2.39399815
35Lymphangioma (HP:0100764)2.38744690
36Insomnia (HP:0100785)2.38676662
37Abnormality of the Achilles tendon (HP:0005109)2.37155869
38Abnormality of reticulocytes (HP:0004312)2.36845417
39Diaphragmatic weakness (HP:0009113)2.33163159
40Hyperammonemia (HP:0001987)2.31446132
41Rhabdomyolysis (HP:0003201)2.31273489
42Abnormality of complement system (HP:0005339)2.30209203
43Turricephaly (HP:0000262)2.29823067
44Abnormality of skeletal muscle fiber size (HP:0012084)2.29467996
45Impaired platelet aggregation (HP:0003540)2.29082288
46Abnormal platelet function (HP:0011869)2.29082288
47Cholelithiasis (HP:0001081)2.28189475
48Asymmetric septal hypertrophy (HP:0001670)2.28132107
49Exercise-induced muscle cramps (HP:0003710)2.28075415
50Spastic diplegia (HP:0001264)2.27727994
51Broad face (HP:0000283)2.27052923
52Hypertensive crisis (HP:0100735)2.24208840
53* Abnormality of the nasal mucosa (HP:0000433)2.22440598
54Mitral valve prolapse (HP:0001634)2.20123153
55Easy fatigability (HP:0003388)2.19611689
56Intrahepatic cholestasis (HP:0001406)2.19369754
57Multiple enchondromatosis (HP:0005701)2.17432211
58Late onset (HP:0003584)2.16925140
59Hypoalphalipoproteinemia (HP:0003233)2.16009960
60Achilles tendon contracture (HP:0001771)2.15896402
61Abnormality of the left ventricular outflow tract (HP:0011103)2.14690252
62Subaortic stenosis (HP:0001682)2.14690252
63Microcytic anemia (HP:0001935)2.13796828
64Recurrent abscess formation (HP:0002722)2.12881599
65Type 1 muscle fiber predominance (HP:0003803)2.12766051
66Hyperglycinemia (HP:0002154)2.11376705
67Gout (HP:0001997)2.09900564
68Disproportionate tall stature (HP:0001519)2.09656546
69Abnormality of glycine metabolism (HP:0010895)2.09369564
70Abnormality of serine family amino acid metabolism (HP:0010894)2.09369564
71Ketoacidosis (HP:0001993)2.09034660
72Chronic obstructive pulmonary disease (HP:0006510)2.08944230
73Obstructive lung disease (HP:0006536)2.08944230
74Atrioventricular block (HP:0001678)2.08638720
75Increased IgE level (HP:0003212)2.06979096
76Joint hemorrhage (HP:0005261)2.06414666
77Conjunctival hamartoma (HP:0100780)2.05716274
78Papilloma (HP:0012740)2.04410098
79Verrucae (HP:0200043)2.04410098
80Recurrent bacterial skin infections (HP:0005406)2.03665654
81Annular pancreas (HP:0001734)2.02687125
82* Nasal polyposis (HP:0100582)2.02406492
83Thrombocytosis (HP:0001894)2.02231707
84Hypoglycemic coma (HP:0001325)2.01768727
85Thin ribs (HP:0000883)2.01761448
86Emphysema (HP:0002097)2.00145599
87Abnormal platelet volume (HP:0011876)1.99125190
88Abnormal gallbladder morphology (HP:0012437)1.98663920
89Hyperlipoproteinemia (HP:0010980)1.98550633
90Increased mean platelet volume (HP:0011877)1.97444492
91Hepatocellular carcinoma (HP:0001402)1.97037768
92Abnormal gallbladder physiology (HP:0012438)1.96841398
93Cholecystitis (HP:0001082)1.96841398
94Menorrhagia (HP:0000132)1.96725635
95Broad distal phalanx of finger (HP:0009836)1.96191319
96Aneurysm (HP:0002617)1.95842771
97Pseudobulbar signs (HP:0002200)1.93346646
98Bulbar palsy (HP:0001283)1.93033222
99Gastrointestinal inflammation (HP:0004386)1.93006660
100Vertebral compression fractures (HP:0002953)1.92489646
101Abnormal hemoglobin (HP:0011902)1.91777180
102Hypertriglyceridemia (HP:0002155)1.91385242
103Testicular atrophy (HP:0000029)1.90747485
104Abnormality of glutamine family amino acid metabolism (HP:0010902)1.90616488
105Polygenic inheritance (HP:0010982)1.90462374
106Calf muscle hypertrophy (HP:0008981)1.89565999
107Increased density of long bones (HP:0006392)1.89562602
108Gingivitis (HP:0000230)1.88613031
109Mildly elevated creatine phosphokinase (HP:0008180)1.88124924
110Genu recurvatum (HP:0002816)1.88114964
111Long palpebral fissure (HP:0000637)1.87685819
112Abnormality of fatty-acid metabolism (HP:0004359)1.87505418
113Hypochromic microcytic anemia (HP:0004840)1.87468318
114Angiofibromas (HP:0010615)1.87329143
115Adenoma sebaceum (HP:0009720)1.87329143
116Long toe (HP:0010511)1.87013297
117Segmental peripheral demyelination/remyelination (HP:0003481)1.86695770
118Metaphyseal cupping (HP:0003021)1.86054143
119Abnormality of the gallbladder (HP:0005264)1.85829549
120Hypercholesterolemia (HP:0003124)1.85136708
121Abnormal cartilage morphology (HP:0002763)1.85117342
122Abnormality of iron homeostasis (HP:0011031)1.84479933
123Abnormality of macrophages (HP:0004311)1.83102893
124Abnormality of cells of the erythroid lineage (HP:0012130)1.83100691
125Lipoatrophy (HP:0100578)1.83074679
126Increased serum ferritin (HP:0003281)1.83069208
127Colitis (HP:0002583)1.82528978
128Progressive muscle weakness (HP:0003323)1.82131313
129Round ear (HP:0100830)1.82100343
130Increased cerebral lipofuscin (HP:0011813)1.81232635
131Truncus arteriosus (HP:0001660)1.81088784
132Spontaneous hematomas (HP:0007420)1.81025220
133Cerebral inclusion bodies (HP:0100314)1.79937723
134Abnormality of sulfur amino acid metabolism (HP:0004339)1.79483259
135Back pain (HP:0003418)1.78961401
136Abnormality of the thoracic spine (HP:0100711)1.78107868
137Ulnar deviation of the wrist (HP:0003049)1.78042247
138Gastrointestinal dysmotility (HP:0002579)1.77735467
139Muscle hypertrophy of the lower extremities (HP:0008968)1.77685435
140Hypolipoproteinemia (HP:0010981)1.77443508
141Bowing of the arm (HP:0006488)1.76187968
142Bowed forearm bones (HP:0003956)1.76187968
143Prolonged partial thromboplastin time (HP:0003645)1.76055741
144Ileus (HP:0002595)1.75083468
145Malnutrition (HP:0004395)1.74087328
146Bowel incontinence (HP:0002607)1.73484045
147Myopathic facies (HP:0002058)1.73349042
148Thoracic kyphosis (HP:0002942)1.72755087
149Abnormality of purine metabolism (HP:0004352)1.71706575
150Increased variability in muscle fiber diameter (HP:0003557)1.71087963
151Acanthocytosis (HP:0001927)1.70363803
152Inflammation of the large intestine (HP:0002037)1.69708656
153Abnormality of transition element cation homeostasis (HP:0011030)1.69554032
154Pustule (HP:0200039)1.69457756
155Dysostosis multiplex (HP:0000943)1.69303220
156Mitral regurgitation (HP:0001653)1.69247059
157Shallow orbits (HP:0000586)1.69137553
158Hyperbilirubinemia (HP:0002904)1.68433264
159Cellulitis (HP:0100658)1.68176379
160Cervical subluxation (HP:0003308)1.68137536
161Protrusio acetabuli (HP:0003179)1.68074661
162EMG: myopathic abnormalities (HP:0003458)1.67302848
163Supernumerary nipples (HP:0002558)1.67158263
164Ragged-red muscle fibers (HP:0003200)1.66423165
165Hypercortisolism (HP:0001578)1.66006214
166Deep palmar crease (HP:0006191)1.65159179
167Lower limb amyotrophy (HP:0007210)1.64434058
168Dysmetric saccades (HP:0000641)1.64124687
169Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.62474315
170Distal upper limb amyotrophy (HP:0007149)1.62145056
171Upper limb amyotrophy (HP:0009129)1.62145056
172Nonimmune hydrops fetalis (HP:0001790)1.62001049
173Abnormality of the distal phalanx of the thumb (HP:0009617)1.61724293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.76947960
2EEF2K4.39411025
3MAP3K103.81537529
4PRPF4B3.70551500
5PKN23.42538134
6SMG13.29328375
7ERN12.98026359
8TTN2.83667420
9BCKDK2.55721880
10SIK12.33972025
11PTK62.27215801
12IRAK31.99450742
13NEK21.93434651
14MAP4K11.91669686
15CDK121.91187246
16NME21.78836484
17TAOK31.72547540
18LRRK21.68671516
19RIPK41.68651845
20ICK1.54160991
21MAP3K131.50143015
22FGFR41.39386880
23RIPK11.38209028
24STK101.30933549
25RPS6KA41.30841209
26SIK21.26704943
27PAK41.26325092
28MAPKAPK31.24175459
29CDK41.20835494
30IRAK41.18117980
31MAP3K11.16700819
32TYK21.14707743
33KSR21.13245110
34EPHB11.11295151
35NEK11.09379156
36STK31.07748190
37MTOR1.07011519
38BLK1.06481428
39MAP2K31.05775970
40RPS6KB21.04467938
41GRK61.00156359
42CDK60.99503619
43TNK20.99015159
44PDGFRA0.98918945
45LATS10.95357346
46MAP3K80.94536868
47CAMK1D0.93024138
48CDC42BPA0.92403879
49BMX0.91443257
50MAPK110.89228389
51IRAK20.88820405
52MAP3K110.85899787
53DYRK1B0.84754198
54FGFR30.84680182
55BTK0.84118463
56HIPK20.84111166
57FES0.83091963
58CAMK1G0.82956200
59PDK30.82078819
60PDK40.82078819
61PAK20.81982206
62STK40.81550913
63PIM10.80298485
64TBK10.78856432
65PRKD30.77371346
66JAK20.76886431
67MAP2K20.76820674
68MAP3K70.75717100
69ZAP700.74398396
70PDK10.74031295
71DMPK0.72663267
72CHUK0.72163330
73BRAF0.72162944
74ALK0.71920951
75ILK0.69693778
76TGFBR20.69395032
77MAP3K140.68233601
78TAOK10.68154178
79MAP3K60.67321321
80* RPS6KL10.67099782
81* RPS6KC10.67099782
82DYRK30.66316714
83* RPS6KA10.64780284
84HCK0.64657867
85CAMKK10.63141933
86ARAF0.62260690
87SGK30.60237543
88TYRO30.59938747
89IKBKE0.58856662
90EPHA20.58566197
91TLK10.58420963
92PRKAA10.57693544
93RET0.56245482
94PRKAA20.56121363
95CSK0.55945286
96MARK30.54899053
97JAK10.53823602
98GSK3A0.52993300
99OBSCN0.51470043
100FLT30.51110745
101* RPS6KA60.50335204
102SIK30.50008305
103PRKD10.48830735
104DAPK30.48565379
105TAOK20.47897153
106PIK3CG0.47379295
107TTK0.46512341
108AKT20.46019519
109CDK90.44533480
110PRKG20.44250649
111TESK20.43977761
112MAP3K30.43809948
113MAPK150.42878897
114AURKB0.42572796
115SYK0.41958668
116MAP2K60.41395988
117MAPKAPK20.40278450
118PHKG20.38293583
119PHKG10.38293583
120PRKD20.38243539
121FGR0.37766887
122TRPM70.37732754
123IKBKB0.37210151
124MAPK40.35763408
125MAPK70.35531286
126STK380.34770503
127PIM20.33604744
128PTK20.33388746
129LMTK20.33024747
130STK240.32529628
131MAPK120.32445763
132JAK30.32222397
133KDR0.32131406
134MAP2K40.32114265
135MARK20.30755667
136CAMK40.30746287
137ITK0.30271822
138PDPK10.29917366
139BRD40.29861258
140* RPS6KA20.29433071
141PDGFRB0.29038222

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58799451
2Fatty acid degradation_Homo sapiens_hsa000712.55567408
3Other glycan degradation_Homo sapiens_hsa005112.54788335
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.34720326
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.32965479
6Sulfur relay system_Homo sapiens_hsa041222.29733450
7PPAR signaling pathway_Homo sapiens_hsa033202.20421915
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.20131469
9Arginine biosynthesis_Homo sapiens_hsa002202.18516061
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.18314197
11Tryptophan metabolism_Homo sapiens_hsa003802.11097777
12Lysine degradation_Homo sapiens_hsa003101.97243225
13Nitrogen metabolism_Homo sapiens_hsa009101.91938748
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91120041
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.81523389
16Propanoate metabolism_Homo sapiens_hsa006401.64986517
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64510801
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.60859004
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.58638991
20Insulin resistance_Homo sapiens_hsa049311.58421795
21Complement and coagulation cascades_Homo sapiens_hsa046101.57989271
22Fat digestion and absorption_Homo sapiens_hsa049751.56319132
23Carbon metabolism_Homo sapiens_hsa012001.53066386
24Pancreatic cancer_Homo sapiens_hsa052121.51676948
25Fructose and mannose metabolism_Homo sapiens_hsa000511.51439440
26Fatty acid metabolism_Homo sapiens_hsa012121.49525459
27Staphylococcus aureus infection_Homo sapiens_hsa051501.42042328
28Caffeine metabolism_Homo sapiens_hsa002321.40758005
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.40632615
30* Adipocytokine signaling pathway_Homo sapiens_hsa049201.38159164
31Selenocompound metabolism_Homo sapiens_hsa004501.37396314
32Chronic myeloid leukemia_Homo sapiens_hsa052201.33333488
33Biosynthesis of amino acids_Homo sapiens_hsa012301.33058980
34Leishmaniasis_Homo sapiens_hsa051401.32333664
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26751479
36ABC transporters_Homo sapiens_hsa020101.23104090
37beta-Alanine metabolism_Homo sapiens_hsa004101.19938907
38Pyruvate metabolism_Homo sapiens_hsa006201.19799159
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.19615755
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.15172212
41Prion diseases_Homo sapiens_hsa050201.14854242
42Glioma_Homo sapiens_hsa052141.12577528
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.12023579
44Small cell lung cancer_Homo sapiens_hsa052221.10891090
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09677216
46Malaria_Homo sapiens_hsa051441.09041952
47Bile secretion_Homo sapiens_hsa049761.08501504
48Acute myeloid leukemia_Homo sapiens_hsa052211.08298920
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.07857814
50GnRH signaling pathway_Homo sapiens_hsa049121.07516962
51T cell receptor signaling pathway_Homo sapiens_hsa046601.06134861
52Hepatitis C_Homo sapiens_hsa051601.05942790
53Ribosome_Homo sapiens_hsa030101.05928718
54Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05634939
55Notch signaling pathway_Homo sapiens_hsa043301.02981418
56One carbon pool by folate_Homo sapiens_hsa006701.01556811
57Butanoate metabolism_Homo sapiens_hsa006501.01148657
58Pentose phosphate pathway_Homo sapiens_hsa000301.01067365
59Hepatitis B_Homo sapiens_hsa051611.00543087
60ErbB signaling pathway_Homo sapiens_hsa040121.00033560
61Non-small cell lung cancer_Homo sapiens_hsa052230.99758728
62* AMPK signaling pathway_Homo sapiens_hsa041520.98427002
63TNF signaling pathway_Homo sapiens_hsa046680.98426537
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.98359221
65Influenza A_Homo sapiens_hsa051640.97232818
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96693301
67Inositol phosphate metabolism_Homo sapiens_hsa005620.93791879
68Tuberculosis_Homo sapiens_hsa051520.92652409
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92490675
70Choline metabolism in cancer_Homo sapiens_hsa052310.92375432
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.92033200
72Bladder cancer_Homo sapiens_hsa052190.90842397
73Insulin signaling pathway_Homo sapiens_hsa049100.89641486
74B cell receptor signaling pathway_Homo sapiens_hsa046620.89580323
75Glucagon signaling pathway_Homo sapiens_hsa049220.88337484
76Starch and sucrose metabolism_Homo sapiens_hsa005000.87920924
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87498128
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87213641
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.85699591
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85077605
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84835658
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84829342
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84606720
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83864763
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.83459939
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.83348778
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.82800973
88HTLV-I infection_Homo sapiens_hsa051660.81863368
89Glycerolipid metabolism_Homo sapiens_hsa005610.81289821
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80931024
91Histidine metabolism_Homo sapiens_hsa003400.80722160
92Prostate cancer_Homo sapiens_hsa052150.80362784
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78618165
94Endocytosis_Homo sapiens_hsa041440.76832509
95* mTOR signaling pathway_Homo sapiens_hsa041500.76760690
96Herpes simplex infection_Homo sapiens_hsa051680.76250974
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76229616
98Lysosome_Homo sapiens_hsa041420.75383472
99Peroxisome_Homo sapiens_hsa041460.75170539
100Chemokine signaling pathway_Homo sapiens_hsa040620.74765496
101Phenylalanine metabolism_Homo sapiens_hsa003600.73408175
102Estrogen signaling pathway_Homo sapiens_hsa049150.73172760
103Measles_Homo sapiens_hsa051620.70972494
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69734624
105Osteoclast differentiation_Homo sapiens_hsa043800.68421540
106* FoxO signaling pathway_Homo sapiens_hsa040680.68176375
107Colorectal cancer_Homo sapiens_hsa052100.67850611
108Long-term potentiation_Homo sapiens_hsa047200.65627438
109Antigen processing and presentation_Homo sapiens_hsa046120.64702794
110MAPK signaling pathway_Homo sapiens_hsa040100.64367410
111* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64170362
112Apoptosis_Homo sapiens_hsa042100.63868972
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63065592
114Viral myocarditis_Homo sapiens_hsa054160.62362309
115Type II diabetes mellitus_Homo sapiens_hsa049300.61606859
116Toxoplasmosis_Homo sapiens_hsa051450.61174610
117Arginine and proline metabolism_Homo sapiens_hsa003300.60820224
118Thyroid cancer_Homo sapiens_hsa052160.59904702
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59575037
120Proteoglycans in cancer_Homo sapiens_hsa052050.58932791
121Folate biosynthesis_Homo sapiens_hsa007900.56652008
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56508199
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.56248747
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55249170
125Fatty acid biosynthesis_Homo sapiens_hsa000610.55124495
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53261334
127Amoebiasis_Homo sapiens_hsa051460.52528137
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52320831
129African trypanosomiasis_Homo sapiens_hsa051430.51105309
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50134781
131Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49680079
132VEGF signaling pathway_Homo sapiens_hsa043700.48552353
133Salmonella infection_Homo sapiens_hsa051320.48433062
134Shigellosis_Homo sapiens_hsa051310.46946470
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46930330
136MicroRNAs in cancer_Homo sapiens_hsa052060.46023356
137Focal adhesion_Homo sapiens_hsa045100.45439307
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.45166322
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44622732
140Prolactin signaling pathway_Homo sapiens_hsa049170.43750849
141Platelet activation_Homo sapiens_hsa046110.43681222
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43007217
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42750645
144Epstein-Barr virus infection_Homo sapiens_hsa051690.42474849
145Renal cell carcinoma_Homo sapiens_hsa052110.42419574
146Dilated cardiomyopathy_Homo sapiens_hsa054140.42291776
147Endometrial cancer_Homo sapiens_hsa052130.42133528
148Rap1 signaling pathway_Homo sapiens_hsa040150.41845329
149Systemic lupus erythematosus_Homo sapiens_hsa053220.41191246
150Galactose metabolism_Homo sapiens_hsa000520.40609670
151HIF-1 signaling pathway_Homo sapiens_hsa040660.40022263
152Viral carcinogenesis_Homo sapiens_hsa052030.38978479
153Retinol metabolism_Homo sapiens_hsa008300.37772126
154Leukocyte transendothelial migration_Homo sapiens_hsa046700.36299121
155Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36238938
156Chemical carcinogenesis_Homo sapiens_hsa052040.36215289

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