STK16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.97884877
2DNA deamination (GO:0045006)5.67034528
3viral transcription (GO:0019083)5.11583292
4ribosomal small subunit biogenesis (GO:0042274)4.94914839
5translational termination (GO:0006415)4.87288951
6GDP-mannose metabolic process (GO:0019673)4.84590853
7left/right pattern formation (GO:0060972)4.61811820
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.60367067
9mannose metabolic process (GO:0006013)4.58944544
10cotranslational protein targeting to membrane (GO:0006613)4.55730293
11protein targeting to ER (GO:0045047)4.49310672
12maturation of SSU-rRNA (GO:0030490)4.33495219
13protein localization to endoplasmic reticulum (GO:0070972)4.31153198
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.25321710
15translational elongation (GO:0006414)4.21920523
16negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.14171083
17negative regulation of erythrocyte differentiation (GO:0045647)4.08904698
18telomere maintenance via semi-conservative replication (GO:0032201)3.77641154
19protein insertion into membrane (GO:0051205)3.76104328
20protein carboxylation (GO:0018214)3.74699202
21peptidyl-glutamic acid carboxylation (GO:0017187)3.74699202
22viral life cycle (GO:0019058)3.68062487
23receptor recycling (GO:0001881)3.66406158
24UTP biosynthetic process (GO:0006228)3.66011991
25cellular protein complex disassembly (GO:0043624)3.65248090
26GTP biosynthetic process (GO:0006183)3.61151163
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.60877293
28UV protection (GO:0009650)3.60669892
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59567499
30L-phenylalanine metabolic process (GO:0006558)3.55589226
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.55589226
32deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55084205
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.54844723
34NADH dehydrogenase complex assembly (GO:0010257)3.54844723
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.54844723
36L-phenylalanine catabolic process (GO:0006559)3.52824844
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.52824844
38regulation of early endosome to late endosome transport (GO:2000641)3.52375730
39L-serine metabolic process (GO:0006563)3.49962057
40serine family amino acid biosynthetic process (GO:0009070)3.46852546
41proteasome assembly (GO:0043248)3.46330427
42cellular response to virus (GO:0098586)3.45937068
43disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.45230863
44killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.45230863
45translational initiation (GO:0006413)3.42938389
46DNA strand elongation involved in DNA replication (GO:0006271)3.41900201
47protein maturation by protein folding (GO:0022417)3.39608916
48DNA strand elongation (GO:0022616)3.34181810
49UTP metabolic process (GO:0046051)3.31778876
50glyoxylate metabolic process (GO:0046487)3.30443664
51protein retention in ER lumen (GO:0006621)3.28985941
52blood coagulation, intrinsic pathway (GO:0007597)3.28243998
53metallo-sulfur cluster assembly (GO:0031163)3.27895368
54iron-sulfur cluster assembly (GO:0016226)3.27895368
55aromatic amino acid family catabolic process (GO:0009074)3.24570381
56translation (GO:0006412)3.19772491
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.18775836
58glycine metabolic process (GO:0006544)3.17133054
59respiratory chain complex IV assembly (GO:0008535)3.12265909
60protein complex disassembly (GO:0043241)3.12194985
61lipopolysaccharide biosynthetic process (GO:0009103)3.11214139
62protein complex biogenesis (GO:0070271)3.10086898
63body morphogenesis (GO:0010171)3.09759687
64pseudouridine synthesis (GO:0001522)3.08769130
65ribosomal large subunit biogenesis (GO:0042273)3.07062420
66protein localization to endosome (GO:0036010)3.06687636
67mitochondrial respiratory chain complex assembly (GO:0033108)3.05139427
68disruption of cells of other organism (GO:0044364)3.04514350
69killing of cells of other organism (GO:0031640)3.04514350
70modulation by symbiont of host cellular process (GO:0044068)3.02951883
71telomere maintenance via recombination (GO:0000722)3.02107663
72indole-containing compound catabolic process (GO:0042436)2.95659760
73indolalkylamine catabolic process (GO:0046218)2.95659760
74tryptophan catabolic process (GO:0006569)2.95659760
75macromolecular complex disassembly (GO:0032984)2.95621202
76proline biosynthetic process (GO:0006561)2.95554831
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93476010
78modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93476010
79positive regulation by organism of defense response of other organism involved in symbiotic interact2.93476010
80modulation by symbiont of host immune response (GO:0052553)2.93476010
81positive regulation by symbiont of host defense response (GO:0052509)2.93476010
82modulation by symbiont of host defense response (GO:0052031)2.93476010
83urea cycle (GO:0000050)2.93127252
84heme biosynthetic process (GO:0006783)2.92748696
85modulation by virus of host process (GO:0019054)2.92099223
86cysteine metabolic process (GO:0006534)2.91073570
87L-methionine salvage (GO:0071267)2.89796365
88L-methionine biosynthetic process (GO:0071265)2.89796365
89amino acid salvage (GO:0043102)2.89796365
90serine family amino acid metabolic process (GO:0009069)2.89723407
91DNA replication initiation (GO:0006270)2.87741432
92positive regulation of cellular amine metabolic process (GO:0033240)2.86580374
93positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.86359627
94guanosine-containing compound biosynthetic process (GO:1901070)2.86358929
95pentose metabolic process (GO:0019321)2.85226628
96maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.83534006
97positive regulation of cellular amide metabolic process (GO:0034250)2.81577844
98ribonucleoprotein complex biogenesis (GO:0022613)2.81193719
99regulation of mitochondrial translation (GO:0070129)2.80859751
100Golgi transport vesicle coating (GO:0048200)2.80798982
101COPI coating of Golgi vesicle (GO:0048205)2.80798982
102telomere maintenance via telomere lengthening (GO:0010833)2.80321913
103protein targeting to membrane (GO:0006612)2.80221496
104platelet dense granule organization (GO:0060155)2.77083519
105termination of RNA polymerase III transcription (GO:0006386)2.76733949
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.76733949
107nuclear-transcribed mRNA catabolic process (GO:0000956)2.75495821
108regulation of chromatin binding (GO:0035561)2.74774242
109cellular component biogenesis (GO:0044085)2.73356081
110urea metabolic process (GO:0019627)2.72491197
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72204082
112motile cilium assembly (GO:0044458)2.70331209
113amyloid precursor protein catabolic process (GO:0042987)2.69936230
114mitochondrial fusion (GO:0008053)2.68830408
115nitrogen cycle metabolic process (GO:0071941)2.68639273
116tryptophan metabolic process (GO:0006568)2.68284478
117regulation of interferon-beta biosynthetic process (GO:0045357)2.66822354
118inner mitochondrial membrane organization (GO:0007007)2.66134035
119amino-acid betaine metabolic process (GO:0006577)2.66045832
120snRNA metabolic process (GO:0016073)2.65655553
121drug transport (GO:0015893)2.65510707
122cellular biogenic amine catabolic process (GO:0042402)2.65508560
123amine catabolic process (GO:0009310)2.65508560
124lipopolysaccharide metabolic process (GO:0008653)2.64974799
125negative regulation of toll-like receptor signaling pathway (GO:0034122)2.64679470
126drug transmembrane transport (GO:0006855)2.64575815
127deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.63179944
128lymphoid progenitor cell differentiation (GO:0002320)2.62747155
129positive regulation of histone deacetylation (GO:0031065)2.62723200
130adenosine receptor signaling pathway (GO:0001973)2.62680236
131pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.62662615
132mRNA catabolic process (GO:0006402)2.62661886
133pteridine-containing compound biosynthetic process (GO:0042559)2.61517746
134negative regulation of cell killing (GO:0031342)2.61131833
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61131833
136pinocytosis (GO:0006907)2.59978237
137rRNA processing (GO:0006364)2.59926951
138quinone biosynthetic process (GO:1901663)2.58717114
139ubiquinone biosynthetic process (GO:0006744)2.58717114
140pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.58045317
141regulation of defense response to virus by virus (GO:0050690)2.57721013
142mitotic recombination (GO:0006312)2.57183063
143regulation of superoxide anion generation (GO:0032928)2.57173139
144response to peptidoglycan (GO:0032494)2.56917619
145response to laminar fluid shear stress (GO:0034616)2.56656357
146regulation of extracellular matrix disassembly (GO:0010715)2.56191557
147exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.56084603
148tRNA methylation (GO:0030488)2.55043109
149positive regulation of Cdc42 GTPase activity (GO:0043089)2.54974271
150CTP metabolic process (GO:0046036)2.53152067
151CTP biosynthetic process (GO:0006241)2.53152067
152rRNA metabolic process (GO:0016072)2.53034679
153stress fiber assembly (GO:0043149)2.52694953
154apoptotic process involved in morphogenesis (GO:0060561)2.51222312
155heme metabolic process (GO:0042168)2.50920671
156bile acid biosynthetic process (GO:0006699)2.50150232
157antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49861471
158proline metabolic process (GO:0006560)2.47080575
159establishment of protein localization to membrane (GO:0090150)2.47028489
160RNA catabolic process (GO:0006401)2.46998148
161negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.46746808
162serine family amino acid catabolic process (GO:0009071)2.46722599
163antigen processing and presentation via MHC class Ib (GO:0002475)2.46640406
164low-density lipoprotein particle clearance (GO:0034383)2.46254142
165mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.46233986
166pyrimidine nucleoside biosynthetic process (GO:0046134)2.45588183
167pteridine-containing compound metabolic process (GO:0042558)2.45027634
168positive regulation of protein deacetylation (GO:0090312)2.44470878
169embryonic body morphogenesis (GO:0010172)2.44037855
170pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.42877655
171regulation of mammary gland epithelial cell proliferation (GO:0033599)2.41868296
172pentose-phosphate shunt (GO:0006098)2.40789392
173antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.40655669
174negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.39317712
175regulation of histone deacetylation (GO:0031063)2.35779599
176activation of MAPKKK activity (GO:0000185)2.35775284
177intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.34883963
178detection of other organism (GO:0098543)2.32208529
179retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.32182085
180heterochromatin organization (GO:0070828)2.31294726
181response to parathyroid hormone (GO:0071107)2.29938078
182negative regulation of fibrinolysis (GO:0051918)2.27395555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00512962
2E2F7_22180533_ChIP-Seq_HELA_Human3.91315324
3* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85571081
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.65533079
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.62601247
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.60880256
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.34658198
8* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.28242920
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.25003148
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.24708037
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.19603025
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.07451315
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03676808
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.98507381
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.94252590
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.86121800
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76218081
18LXR_22292898_ChIP-Seq_THP-1_Human2.68252643
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.68133330
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.59499980
21CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.58523920
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.50827312
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.43931767
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43271463
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.40955858
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.34629376
27TP63_17297297_ChIP-ChIP_HaCaT_Human2.33644026
28MYC_22102868_ChIP-Seq_BL_Human2.30000884
29FOXP3_21729870_ChIP-Seq_TREG_Human2.22316424
30RACK7_27058665_Chip-Seq_MCF-7_Human2.21435452
31* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.20365846
32RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18173691
33VDR_23849224_ChIP-Seq_CD4+_Human2.16357887
34ELK3_25401928_ChIP-Seq_HUVEC_Human2.15932710
35* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10318868
36SRF_21415370_ChIP-Seq_HL-1_Mouse2.10063179
37KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09718513
38MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09190115
39MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04793288
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04774938
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.95907044
42* RXR_22158963_ChIP-Seq_LIVER_Mouse1.95799519
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.95126418
44SCL_19346495_ChIP-Seq_HPC-7_Human1.94889795
45XRN2_22483619_ChIP-Seq_HELA_Human1.94702928
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92529442
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89374888
48* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.87687241
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.86754068
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86215211
51* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84072993
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82599988
53IRF1_19129219_ChIP-ChIP_H3396_Human1.82451876
54KDM2B_26808549_Chip-Seq_DND41_Human1.82016069
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.81546979
56* MAF_26560356_Chip-Seq_TH1_Human1.80616695
57TCF7_22412390_ChIP-Seq_EML_Mouse1.79728435
58DCP1A_22483619_ChIP-Seq_HELA_Human1.77869901
59* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.77474360
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76918710
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.76511693
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75410861
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72631520
64* GABP_19822575_ChIP-Seq_HepG2_Human1.72346642
65MAF_26560356_Chip-Seq_TH2_Human1.68668063
66P68_20966046_ChIP-Seq_HELA_Human1.68426598
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66573230
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63237436
69SA1_27219007_Chip-Seq_ERYTHROID_Human1.63097708
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58929627
71TTF2_22483619_ChIP-Seq_HELA_Human1.58727858
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57510557
73* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.53116426
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52425653
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.51891308
76VDR_21846776_ChIP-Seq_THP-1_Human1.49654709
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49323340
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.48299585
79EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47496638
80UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47374037
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.46000517
82CREB1_26743006_Chip-Seq_LNCaP_Human1.45903893
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45519227
84* UTX_26944678_Chip-Seq_JUKART_Human1.45130186
85CIITA_25753668_ChIP-Seq_RAJI_Human1.43986249
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.43263222
87KDM2B_26808549_Chip-Seq_K562_Human1.41027270
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38768977
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37013917
90ZNF263_19887448_ChIP-Seq_K562_Human1.36494070
91MYC_18940864_ChIP-ChIP_HL60_Human1.35726612
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.35237696
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33431726
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32893307
95NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32698502
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32691336
97SMC4_20622854_ChIP-Seq_HELA_Human1.32143139
98* KDM2B_26808549_Chip-Seq_JURKAT_Human1.31814805
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30657836
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.30413141
101GATA1_22025678_ChIP-Seq_K562_Human1.30156244
102* SPI1_23547873_ChIP-Seq_NB4_Human1.29705760
103IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29594194
104ATF3_27146783_Chip-Seq_COLON_Human1.28408554
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.28027425
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26469698
107BCOR_27268052_Chip-Seq_Bcells_Human1.25575775
108KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25326821
109ELK1_19687146_ChIP-ChIP_HELA_Human1.23704337
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23657508
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23062364
112BCL6_27268052_Chip-Seq_Bcells_Human1.22855633
113* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.22650836
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22615576
115* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22383550
116KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22144691
117MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21542413
118NCOR1_26117541_ChIP-Seq_K562_Human1.21033640
119* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20884635
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20850187
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19669869
122IRF8_22096565_ChIP-ChIP_GC-B_Human1.19002830
123* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18935742
124CTCF_21964334_Chip-Seq_Bcells_Human1.18917178
125PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18710267
126CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.18023956
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17987107
128KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16584229
129E2F1_21310950_ChIP-Seq_MCF-7_Human1.16478532
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16472757
131HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15717659
132MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15544812
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15518934
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15408121
135EGR1_19374776_ChIP-ChIP_THP-1_Human1.15000378
136TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14798897
137GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13525019
138TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10636416
139HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09887919
140PHF8_20622854_ChIP-Seq_HELA_Human1.08513312
141* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08391010
142* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07032157
143MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06883019
144RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06237162
145* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06114240
146CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04692611
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03602988
148TP53_22127205_ChIP-Seq_IMR90_Human1.03213015
149SA1_27219007_Chip-Seq_Bcells_Human1.02682744
150CTCF_27219007_Chip-Seq_Bcells_Human1.01853070
151MYB_21317192_ChIP-Seq_ERMYB_Mouse1.00778946
152* RARA_24833708_ChIP-Seq_LIVER_Mouse1.00306438
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99866065
154PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99102149
155E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94797052
156YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94632448
157CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91934157
158YY1_22570637_ChIP-Seq_MALME-3M_Human0.89039775
159CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.88890155
160LXR_22158963_ChIP-Seq_LIVER_Mouse0.87949365
161VDR_24763502_ChIP-Seq_THP-1_Human0.84832480
162* RUNX1_22412390_ChIP-Seq_EML_Mouse0.81851018
163STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81454419
164GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81134185
165EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80717531
166* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80320256
167STAT1_20625510_ChIP-Seq_HELA_Human0.80244742
168CTCF_26484167_Chip-Seq_Bcells_Mouse0.78340561
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.77949679
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76454771
171FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75695500
172NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.75509319
173POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.74280675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.90570551
2MP0005360_urolithiasis4.10309691
3MP0003123_paternal_imprinting3.68227034
4MP0005365_abnormal_bile_salt3.55146638
5MP0003705_abnormal_hypodermis_morpholog3.36513376
6MP0005085_abnormal_gallbladder_physiolo3.33121032
7MP0005058_abnormal_lysosome_morphology3.17862939
8MP0009379_abnormal_foot_pigmentation3.14035362
9MP0008875_abnormal_xenobiotic_pharmacok2.86189236
10MP0003693_abnormal_embryo_hatching2.66818616
11MP0003303_peritoneal_inflammation2.59073075
12MP0002877_abnormal_melanocyte_morpholog2.56890763
13MP0002396_abnormal_hematopoietic_system2.47437925
14MP0003806_abnormal_nucleotide_metabolis2.39725499
15MP0008057_abnormal_DNA_replication2.34009064
16MP0004147_increased_porphyrin_level2.21753121
17MP0003656_abnormal_erythrocyte_physiolo2.14579858
18MP0002132_abnormal_respiratory_system2.11275013
19MP0001764_abnormal_homeostasis2.10887308
20MP0005075_abnormal_melanosome_morpholog2.07676398
21MP0009840_abnormal_foam_cell2.06453453
22MP0006292_abnormal_olfactory_placode2.06286791
23MP0003172_abnormal_lysosome_physiology2.03824653
24MP0002102_abnormal_ear_morphology2.02366785
25MP0008260_abnormal_autophagy2.01987948
26MP0003186_abnormal_redox_activity1.95607046
27MP0003724_increased_susceptibility_to1.94392963
28MP0005332_abnormal_amino_acid1.90207072
29MP0003453_abnormal_keratinocyte_physiol1.89796225
30MP0001666_abnormal_nutrient_absorption1.85243107
31MP0005174_abnormal_tail_pigmentation1.85092188
32MP0006036_abnormal_mitochondrial_physio1.81198200
33MP0008058_abnormal_DNA_repair1.80169619
34MP0002822_catalepsy1.79638026
35MP0003252_abnormal_bile_duct1.76486685
36MP0000685_abnormal_immune_system1.76293740
37MP0003868_abnormal_feces_composition1.73676923
38MP0005084_abnormal_gallbladder_morpholo1.72070797
39MP0005083_abnormal_biliary_tract1.70784023
40MP0003195_calcinosis1.66586468
41MP0003136_yellow_coat_color1.64528079
42MP0010094_abnormal_chromosome_stability1.64108670
43MP0005220_abnormal_exocrine_pancreas1.63226496
44MP0003879_abnormal_hair_cell1.62303172
45MP0000858_altered_metastatic_potential1.61183226
46MP0003111_abnormal_nucleus_morphology1.58015346
47MP0002089_abnormal_postnatal_growth/wei1.56518075
48MP0004019_abnormal_vitamin_homeostasis1.55007942
49MP0003300_gastrointestinal_ulcer1.53906314
50MP0000490_abnormal_crypts_of1.50892546
51MP0010329_abnormal_lipoprotein_level1.50783470
52MP0001986_abnormal_taste_sensitivity1.48260582
53MP0005076_abnormal_cell_differentiation1.46518963
54MP0005636_abnormal_mineral_homeostasis1.40185256
55MP0005409_darkened_coat_color1.39530940
56MP0004947_skin_inflammation1.37400901
57MP0002653_abnormal_ependyma_morphology1.36623992
58MP0001849_ear_inflammation1.35413515
59MP0000465_gastrointestinal_hemorrhage1.32697488
60MP0000678_abnormal_parathyroid_gland1.32393423
61MP0004858_abnormal_nervous_system1.32079410
62MP0005451_abnormal_body_composition1.31602987
63MP0005397_hematopoietic_system_phenotyp1.28968926
64MP0001545_abnormal_hematopoietic_system1.28968926
65MP0004957_abnormal_blastocyst_morpholog1.28709383
66MP0001348_abnormal_lacrimal_gland1.28076228
67MP0005666_abnormal_adipose_tissue1.26354368
68MP0009785_altered_susceptibility_to1.25201863
69MP0001790_abnormal_immune_system1.25184680
70MP0005387_immune_system_phenotype1.25184680
71MP0004381_abnormal_hair_follicle1.24760267
72MP0004185_abnormal_adipocyte_glucose1.23931874
73MP0005319_abnormal_enzyme/_coenzyme1.22959947
74MP0005464_abnormal_platelet_physiology1.22513612
75MP0010234_abnormal_vibrissa_follicle1.22343482
76MP0006035_abnormal_mitochondrial_morpho1.20413831
77MP0008469_abnormal_protein_level1.20267468
78MP0009333_abnormal_splenocyte_physiolog1.19397143
79MP0002138_abnormal_hepatobiliary_system1.18793761
80MP0004510_myositis1.16969030
81MP0005375_adipose_tissue_phenotype1.16131806
82MP0005501_abnormal_skin_physiology1.14439211
83MP0005025_abnormal_response_to1.14149595
84MP0001533_abnormal_skeleton_physiology1.13533525
85MP0008007_abnormal_cellular_replicative1.13234059
86MP0009643_abnormal_urine_homeostasis1.13029819
87MP0001188_hyperpigmentation1.11312378
88MP0004233_abnormal_muscle_weight1.10820459
89MP0000604_amyloidosis1.10271802
90MP0003077_abnormal_cell_cycle1.10011563
91MP0005584_abnormal_enzyme/coenzyme_acti1.09725888
92MP0003183_abnormal_peptide_metabolism1.09234349
93MP0000003_abnormal_adipose_tissue1.09162893
94MP0003566_abnormal_cell_adhesion1.08028707
95MP0003329_amyloid_beta_deposits1.07741293
96MP0005257_abnormal_intraocular_pressure1.06337824
97MP0002095_abnormal_skin_pigmentation1.05525433
98MP0001835_abnormal_antigen_presentation1.05453069
99MP0003763_abnormal_thymus_physiology1.05251324
100MP0002452_abnormal_antigen_presenting1.04389606
101MP0000609_abnormal_liver_physiology1.02883420
102MP0002938_white_spotting1.01864725
103MP0000689_abnormal_spleen_morphology1.00722189
104MP0004264_abnormal_extraembryonic_tissu1.00578417
105MP0005000_abnormal_immune_tolerance0.99031005
106MP0001800_abnormal_humoral_immune0.98928366
107MP0003191_abnormal_cellular_cholesterol0.98838490
108MP0005670_abnormal_white_adipose0.98479721
109MP0009765_abnormal_xenobiotic_induced0.97368506
110MP0005671_abnormal_response_to0.96495742
111MP0009053_abnormal_anal_canal0.95888588
112MP0002722_abnormal_immune_system0.93305935
113MP0010155_abnormal_intestine_physiology0.93105731
114MP0000750_abnormal_muscle_regeneration0.92846238
115MP0002118_abnormal_lipid_homeostasis0.92325923
116MP0002398_abnormal_bone_marrow0.92170218
117MP0002796_impaired_skin_barrier0.90986070
118MP0010030_abnormal_orbit_morphology0.90919561
119MP0002429_abnormal_blood_cell0.90681649
120MP0009763_increased_sensitivity_to0.90579663
121MP0003436_decreased_susceptibility_to0.90081608
122MP0001845_abnormal_inflammatory_respons0.87942596
123MP0001663_abnormal_digestive_system0.87594620
124MP0000716_abnormal_immune_system0.86535545
125MP0003718_maternal_effect0.86291578
126MP0003866_abnormal_defecation0.86173202
127MP0002876_abnormal_thyroid_physiology0.85509788
128MP0002419_abnormal_innate_immunity0.84991649
129MP0003075_altered_response_to0.84730472
130MP0001853_heart_inflammation0.84720077
131MP0000015_abnormal_ear_pigmentation0.83978814
132MP0003091_abnormal_cell_migration0.82579557
133MP0003011_delayed_dark_adaptation0.82540879
134MP0003315_abnormal_perineum_morphology0.81515769
135MP0004808_abnormal_hematopoietic_stem0.81365220
136MP0001873_stomach_inflammation0.78057279
137MP0002998_abnormal_bone_remodeling0.77959750
138MP0003786_premature_aging0.77721240
139MP0009642_abnormal_blood_homeostasis0.77071816
140MP0005381_digestive/alimentary_phenotyp0.76983602
141MP0002723_abnormal_immune_serum0.76587938
142MP0000598_abnormal_liver_morphology0.76156877
143MP0004142_abnormal_muscle_tone0.76143835
144MP0009931_abnormal_skin_appearance0.76092728
145MP0001485_abnormal_pinna_reflex0.75965951
146MP0002420_abnormal_adaptive_immunity0.75893247
147MP0005379_endocrine/exocrine_gland_phen0.75478687
148MP0008877_abnormal_DNA_methylation0.74431918
149MP0008932_abnormal_embryonic_tissue0.74146238
150MP0001756_abnormal_urination0.74111631
151MP0009764_decreased_sensitivity_to0.73890324
152MP0008874_decreased_physiological_sensi0.73655674
153MP0001819_abnormal_immune_cell0.73631770
154MP0000343_altered_response_to0.73377373
155MP0002019_abnormal_tumor_incidence0.73282441
156MP0000703_abnormal_thymus_morphology0.71679959
157MP0009697_abnormal_copulation0.70534894
158MP0003959_abnormal_lean_body0.69389384
159MP0002136_abnormal_kidney_physiology0.68659311
160MP0001216_abnormal_epidermal_layer0.68145683

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.83506887
2Abnormality of cells of the erythroid lineage (HP:0012130)4.76770803
3Reticulocytopenia (HP:0001896)4.52653469
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.12845327
5Reduced antithrombin III activity (HP:0001976)4.02941718
6Aplastic anemia (HP:0001915)3.98110897
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.87025026
8Hyperparathyroidism (HP:0000843)3.64135008
9Macrocytic anemia (HP:0001972)3.47052106
10Prolonged partial thromboplastin time (HP:0003645)3.42454232
11Type I transferrin isoform profile (HP:0003642)3.32360891
12Vertebral compression fractures (HP:0002953)3.28054986
13Purpura (HP:0000979)3.24253483
14Pallor (HP:0000980)3.22436832
15Abnormality of macrophages (HP:0004311)3.10028836
16Intrahepatic cholestasis (HP:0001406)3.09246621
17Hemorrhage of the eye (HP:0011885)3.05941336
18Poikiloderma (HP:0001029)3.04543942
19Entropion (HP:0000621)3.02672154
20Hepatic necrosis (HP:0002605)3.02610584
21Nasal polyposis (HP:0100582)3.01952524
22Thin bony cortex (HP:0002753)2.99134844
23Mitochondrial inheritance (HP:0001427)2.95135045
24Abnormality of pyrimidine metabolism (HP:0004353)2.93020973
25Acute encephalopathy (HP:0006846)2.92190472
26Eczematoid dermatitis (HP:0000976)2.88709236
27Acute necrotizing encephalopathy (HP:0006965)2.87412954
28Dicarboxylic aciduria (HP:0003215)2.87156405
29Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87156405
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.86391016
31Hepatocellular necrosis (HP:0001404)2.86302166
32Conjugated hyperbilirubinemia (HP:0002908)2.85048113
33Abnormal protein glycosylation (HP:0012346)2.84541774
34Abnormal glycosylation (HP:0012345)2.84541774
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.84541774
36Abnormal protein N-linked glycosylation (HP:0012347)2.84541774
37Recurrent bacterial skin infections (HP:0005406)2.84039617
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.77060127
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.77060127
40Abnormal mitochondria in muscle tissue (HP:0008316)2.76900107
41Pancytopenia (HP:0001876)2.75156955
42Deep palmar crease (HP:0006191)2.74014973
43Delayed CNS myelination (HP:0002188)2.68266732
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.67681703
45Petechiae (HP:0000967)2.67280225
46Multiple lipomas (HP:0001012)2.66960358
47Increased CSF lactate (HP:0002490)2.66148441
48Recurrent abscess formation (HP:0002722)2.66075246
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.65815352
50Hyperbilirubinemia (HP:0002904)2.64223124
51Opisthotonus (HP:0002179)2.62645647
52Cerebral edema (HP:0002181)2.60478278
53Increased serum lactate (HP:0002151)2.60277710
54Abnormality of the nasal mucosa (HP:0000433)2.59106322
55Generalized aminoaciduria (HP:0002909)2.57354181
56Thrombocytosis (HP:0001894)2.54875226
57Oral leukoplakia (HP:0002745)2.54204361
583-Methylglutaconic aciduria (HP:0003535)2.53860023
59Lipid accumulation in hepatocytes (HP:0006561)2.49764750
60Hypobetalipoproteinemia (HP:0003563)2.48759794
61Renal Fanconi syndrome (HP:0001994)2.48512474
62Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46824024
63Abnormality of the Achilles tendon (HP:0005109)2.45482338
64Joint hemorrhage (HP:0005261)2.44571790
65Lactic acidosis (HP:0003128)2.43768038
66Recurrent gram-negative bacterial infections (HP:0005420)2.43228747
67Increased hepatocellular lipid droplets (HP:0006565)2.41708381
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.41272589
69Lethargy (HP:0001254)2.39232741
70Hyperthyroidism (HP:0000836)2.38722678
71Abnormality of fatty-acid metabolism (HP:0004359)2.37588517
72Abnormality of methionine metabolism (HP:0010901)2.36872211
73Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.36754225
74Microvesicular hepatic steatosis (HP:0001414)2.36637806
75Long palpebral fissure (HP:0000637)2.32973430
76Achilles tendon contracture (HP:0001771)2.30662508
77Increased intramyocellular lipid droplets (HP:0012240)2.29940683
78Cellulitis (HP:0100658)2.29295589
79Abnormality of aspartate family amino acid metabolism (HP:0010899)2.28810049
80Abnormality of serum amino acid levels (HP:0003112)2.27646732
81Chronic otitis media (HP:0000389)2.27218949
82Dysostosis multiplex (HP:0000943)2.27190538
83Hyperglycinemia (HP:0002154)2.25122997
84Neonatal hypoglycemia (HP:0001998)2.24343949
85Increased muscle lipid content (HP:0009058)2.23825186
86Protrusio acetabuli (HP:0003179)2.23504742
87Hyperammonemia (HP:0001987)2.22962046
88Epistaxis (HP:0000421)2.22173768
89Prolonged bleeding time (HP:0003010)2.21886816
90Hypercortisolism (HP:0001578)2.20947148
91Microcytic anemia (HP:0001935)2.19090893
92Megaloblastic anemia (HP:0001889)2.18307115
93Abnormality of glycine metabolism (HP:0010895)2.17888609
94Abnormality of serine family amino acid metabolism (HP:0010894)2.17888609
95Progressive macrocephaly (HP:0004481)2.17296344
96Ketosis (HP:0001946)2.16891466
97Increased cerebral lipofuscin (HP:0011813)2.16817265
98IgM deficiency (HP:0002850)2.16533773
99Hyperglycinuria (HP:0003108)2.14001177
100Chronic obstructive pulmonary disease (HP:0006510)2.13077152
101Obstructive lung disease (HP:0006536)2.13077152
102Abnormality of urine glucose concentration (HP:0011016)2.11567124
103Glycosuria (HP:0003076)2.11567124
104Hypoglycemic coma (HP:0001325)2.10337137
105Xanthomatosis (HP:0000991)2.10108555
106Atelectasis (HP:0100750)2.08951546
107Vacuolated lymphocytes (HP:0001922)2.08222543
108Abnormality of reticulocytes (HP:0004312)2.07641111
109Methylmalonic aciduria (HP:0012120)2.06457103
110Hypercalcemia (HP:0003072)2.06353021
111Flat acetabular roof (HP:0003180)2.05253670
112Abnormality of the thoracic spine (HP:0100711)2.04365291
113Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03731394
114Short nail (HP:0001799)2.03150181
115Hypertensive crisis (HP:0100735)2.02385031
116Thyroid-stimulating hormone excess (HP:0002925)2.01892931
117Hypophosphatemia (HP:0002148)1.99974002
118Prolonged neonatal jaundice (HP:0006579)1.99463293
119Neutropenia (HP:0001875)1.99431007
120Hypoplasia of the thymus (HP:0000778)1.98261051
121Pathologic fracture (HP:0002756)1.97744036
122Polygenic inheritance (HP:0010982)1.94822244
123Increased neuronal autofluorescent lipopigment (HP:0002074)1.94005476
124Brushfield spots (HP:0001088)1.93395490
125Deep venous thrombosis (HP:0002625)1.93280580
126Metabolic acidosis (HP:0001942)1.92540984
127Acute lymphatic leukemia (HP:0006721)1.92057534
128Renal cortical cysts (HP:0000803)1.91524883
129Abnormality of the common coagulation pathway (HP:0010990)1.91420517
130Ulnar bowing (HP:0003031)1.90929020
131Generalized hyperpigmentation (HP:0007440)1.89924990
132Gastrointestinal stroma tumor (HP:0100723)1.89879538
133Mucopolysacchariduria (HP:0008155)1.88881336
134Urinary glycosaminoglycan excretion (HP:0003541)1.88881336
135Abnormality of renal resorption (HP:0011038)1.88327428
136Severe visual impairment (HP:0001141)1.88039000
137Squamous cell carcinoma (HP:0002860)1.86776832
138Exertional dyspnea (HP:0002875)1.84557846
139Abnormality of alanine metabolism (HP:0010916)1.84407313
140Hyperalaninemia (HP:0003348)1.84407313
141Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84407313
142Hyperacusis (HP:0010780)1.84315553
143Abnormality of sulfur amino acid metabolism (HP:0004339)1.83255283
144Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.82216243
145Hypophosphatemic rickets (HP:0004912)1.82206444
146Abnormal trabecular bone morphology (HP:0100671)1.82047776
147Abnormality of DNA repair (HP:0003254)1.82009546
148Emphysema (HP:0002097)1.81982577
149Elevated erythrocyte sedimentation rate (HP:0003565)1.81280763
150Exercise intolerance (HP:0003546)1.81238872
151Short femoral neck (HP:0100864)1.80504141
152Acanthocytosis (HP:0001927)1.80468472
153Gingivitis (HP:0000230)1.79667007
154Elevated hepatic transaminases (HP:0002910)1.79297114
155Asplenia (HP:0001746)1.78782145
156Vascular calcification (HP:0004934)1.77486881
157Systemic lupus erythematosus (HP:0002725)1.77005765
158Gastrointestinal infarctions (HP:0005244)1.76132143
159Increased serum ferritin (HP:0003281)1.76121501
160Rickets (HP:0002748)1.75225000
161Male infertility (HP:0003251)1.75119394
162Abnormality of mucopolysaccharide metabolism (HP:0011020)1.74141840
163Abnormality of polysaccharide metabolism (HP:0011012)1.74141840
164Abnormality of glycosaminoglycan metabolism (HP:0004371)1.74141840
165Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.73704659
166Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72648408
167Obstructive sleep apnea (HP:0002870)1.72381420
168Bone pain (HP:0002653)1.71545349
169Thoracic kyphosis (HP:0002942)1.70382221
170Anomalous pulmonary venous return (HP:0010772)1.69903083
171Hypertriglyceridemia (HP:0002155)1.68968932
172Asymmetry of the thorax (HP:0001555)1.68161773
173Abnormality of the distal phalanges of the toes (HP:0010182)1.68104947
174Turricephaly (HP:0000262)1.67210847
175Neurofibrillary tangles (HP:0002185)1.66169953
176Menorrhagia (HP:0000132)1.65745852
177Progressive muscle weakness (HP:0003323)1.65653199
178Abnormality of the intrinsic pathway (HP:0010989)1.64088446
179Abnormality of the pulmonary veins (HP:0011718)1.62718251
180Cervical subluxation (HP:0003308)1.62487568
181Hypochromic anemia (HP:0001931)1.62361316
182Testicular neoplasm (HP:0010788)1.61465651
183Rough bone trabeculation (HP:0100670)1.61211245
184Gastrointestinal dysmotility (HP:0002579)1.61164630
185Menstrual irregularities (HP:0000858)1.60570234

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.73967227
2TRIB34.64355706
3* STK164.29688441
4TNIK3.47421369
5PRPF4B3.07208718
6TLK12.87770602
7BUB12.85087001
8ICK2.82175082
9BCKDK2.80430624
10EIF2AK12.68459769
11WEE12.67389006
12RIPK42.63924199
13SMG12.58819357
14PIM22.44198928
15SIK12.37198974
16VRK12.26134132
17KIT2.11218397
18TEC2.03639767
19MAP4K12.00362654
20EEF2K1.96677169
21CDK191.93667421
22BLK1.85295842
23DYRK31.83954399
24FLT31.80243822
25EIF2AK31.73829013
26TAOK31.68225374
27MKNK21.65739142
28IRAK41.62269913
29PKN21.59672662
30BTK1.59288237
31EPHA21.54612583
32ARAF1.52806140
33SRPK11.52426755
34MKNK11.52018033
35FGFR41.50113509
36CDK121.49620380
37KDR1.49565556
38TAOK21.47362683
39PTK61.40134006
40FES1.39140701
41PDPK11.37801470
42MAP3K11.36548577
43MAP3K111.35898071
44LRRK21.27392343
45MARK21.27107234
46MUSK1.20121432
47CSK1.19307712
48PRKD21.15838226
49EIF2AK21.14282914
50KSR21.12623688
51BRSK21.10693283
52CDK71.09812335
53TESK21.03232233
54EPHB11.02171520
55RIPK11.01935059
56TXK0.99561581
57MAPKAPK50.99146371
58TNK20.97789379
59DMPK0.97787085
60TAOK10.95513045
61RAF10.93696278
62MAPK150.93237047
63LYN0.92961225
64MAP3K30.90839838
65ACVR1B0.89883896
66IRAK30.89125842
67HIPK20.88627655
68MAP3K100.88406552
69ILK0.88007734
70CCNB10.87831517
71PDK10.86435474
72MAPK120.86355476
73TESK10.86145150
74NLK0.86127645
75MAPK40.85587422
76NUAK10.85093878
77MTOR0.84059060
78PASK0.83402347
79SYK0.82007281
80PIK3CG0.80614758
81BMX0.79193531
82CLK10.77439325
83PDK20.77283416
84MAP2K30.76727492
85MAP3K80.76507121
86AURKB0.75965209
87SIK20.75614704
88AURKA0.75522636
89RPS6KA40.74735518
90ADRBK20.74181385
91CDC42BPA0.72367764
92IRAK10.71788735
93MAP3K20.70983366
94RPS6KB20.70888913
95CDC70.70625650
96CSF1R0.70208488
97ZAP700.69619255
98YES10.68875702
99IRAK20.68578747
100IKBKE0.68262061
101ATR0.67512075
102RPS6KA20.67254044
103RPS6KL10.67110889
104RPS6KC10.67110889
105MAP3K90.66091529
106DDR20.65342444
107DAPK30.63735008
108PLK10.62737580
109ABL20.62250140
110TYK20.58663009
111MAPKAPK30.58081906
112CAMKK20.57973556
113TIE10.57959403
114CSNK2A10.56850238
115PAK40.56728973
116TGFBR10.56068192
117ERN10.55732050
118CSNK2A20.55682632
119TBK10.55073254
120INSRR0.54741801
121CSNK1G30.54385773
122MAPK110.54162420
123CDK40.53249237
124MAP2K70.52724102
125SCYL20.52576484
126BRAF0.52526951
127NEK20.52246239
128RPS6KA60.52200544
129NME10.52175654
130MAP2K60.50112729
131RPS6KA50.49952103
132TYRO30.49666000
133MAPK130.49500198
134LCK0.49103561
135PDGFRA0.48139222
136RET0.48112477
137WNK30.47422365
138CAMKK10.45814121
139JAK20.43492157
140MAP3K120.43439585
141OXSR10.43414764
142ZAK0.41675443
143CAMK10.41127295
144PINK10.41103478
145MAP2K20.40938644
146IKBKB0.40869655
147GRK10.40852045
148DYRK20.40610965
149DYRK1B0.40548933
150PAK10.39980612
151MAPK70.39886930
152NEK90.38863748
153CSNK1G10.37679356
154FGFR30.36867703
155MST1R0.35119400
156MATK0.34986416
157STK240.34041705
158MAP3K140.33960125
159CDK30.33848616
160GRK60.33427315
161PLK40.32452668
162PTK20.32194635
163RPS6KA10.32135335
164AKT20.32032649
165STK40.31793314
166CAMK1D0.31787992

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.02250234
2DNA replication_Homo sapiens_hsa030303.19860185
3Protein export_Homo sapiens_hsa030602.62631217
4Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.49611581
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.46542864
6B cell receptor signaling pathway_Homo sapiens_hsa046622.27153784
7VEGF signaling pathway_Homo sapiens_hsa043702.20965144
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.15927217
9Non-small cell lung cancer_Homo sapiens_hsa052232.15632533
10Pyrimidine metabolism_Homo sapiens_hsa002402.14899765
11Acute myeloid leukemia_Homo sapiens_hsa052212.13189848
12Mismatch repair_Homo sapiens_hsa034302.10485309
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.10301386
14Homologous recombination_Homo sapiens_hsa034402.06740972
15Folate biosynthesis_Homo sapiens_hsa007902.05831170
16RNA polymerase_Homo sapiens_hsa030202.03979932
17Chronic myeloid leukemia_Homo sapiens_hsa052201.95988908
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.95331330
19Notch signaling pathway_Homo sapiens_hsa043301.91656835
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.90814128
21Sulfur relay system_Homo sapiens_hsa041221.89002248
22Proteasome_Homo sapiens_hsa030501.87300558
23Bladder cancer_Homo sapiens_hsa052191.84353302
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.78049562
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76804018
26Peroxisome_Homo sapiens_hsa041461.71086989
27One carbon pool by folate_Homo sapiens_hsa006701.68646463
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.67359884
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.64898678
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64713253
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.62701226
32Base excision repair_Homo sapiens_hsa034101.61611612
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59091737
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58797544
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56984287
36Nucleotide excision repair_Homo sapiens_hsa034201.56717325
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.56275754
38Endometrial cancer_Homo sapiens_hsa052131.53438576
39Spliceosome_Homo sapiens_hsa030401.52598687
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.51402392
41Tryptophan metabolism_Homo sapiens_hsa003801.49214535
42Pancreatic cancer_Homo sapiens_hsa052121.49167005
43Selenocompound metabolism_Homo sapiens_hsa004501.48228469
44Osteoclast differentiation_Homo sapiens_hsa043801.48152031
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.45300538
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.44676221
47Fatty acid degradation_Homo sapiens_hsa000711.44057418
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43714466
49Histidine metabolism_Homo sapiens_hsa003401.35484232
50Renal cell carcinoma_Homo sapiens_hsa052111.34143746
51Pentose phosphate pathway_Homo sapiens_hsa000301.31433638
52Oxidative phosphorylation_Homo sapiens_hsa001901.29857627
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28146589
54Fatty acid elongation_Homo sapiens_hsa000621.27820452
55Alcoholism_Homo sapiens_hsa050341.27436096
56Fanconi anemia pathway_Homo sapiens_hsa034601.26656015
57Butanoate metabolism_Homo sapiens_hsa006501.26354713
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.26151045
59beta-Alanine metabolism_Homo sapiens_hsa004101.25280349
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24228605
61Hepatitis C_Homo sapiens_hsa051601.23182438
62Parkinsons disease_Homo sapiens_hsa050121.23050813
63Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20966055
64Steroid hormone biosynthesis_Homo sapiens_hsa001401.20696985
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20671460
66Insulin signaling pathway_Homo sapiens_hsa049101.20623471
67Prion diseases_Homo sapiens_hsa050201.19268753
68Thyroid cancer_Homo sapiens_hsa052161.18607591
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18561768
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17418888
71Lysosome_Homo sapiens_hsa041421.15365436
72Vitamin digestion and absorption_Homo sapiens_hsa049771.14915153
73Propanoate metabolism_Homo sapiens_hsa006401.14866756
74Central carbon metabolism in cancer_Homo sapiens_hsa052301.13459352
75Retinol metabolism_Homo sapiens_hsa008301.12365951
76Glutathione metabolism_Homo sapiens_hsa004801.11579608
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09333853
78Purine metabolism_Homo sapiens_hsa002301.06936549
79Sulfur metabolism_Homo sapiens_hsa009201.04078136
80Non-homologous end-joining_Homo sapiens_hsa034501.03442679
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03178997
82Arginine and proline metabolism_Homo sapiens_hsa003301.02471255
83Adipocytokine signaling pathway_Homo sapiens_hsa049201.02079798
84Prolactin signaling pathway_Homo sapiens_hsa049171.00556392
85Viral carcinogenesis_Homo sapiens_hsa052031.00516558
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00109026
87Chemical carcinogenesis_Homo sapiens_hsa052040.99411671
88Apoptosis_Homo sapiens_hsa042100.99006902
89Vitamin B6 metabolism_Homo sapiens_hsa007500.97448738
90Vibrio cholerae infection_Homo sapiens_hsa051100.97288522
91ABC transporters_Homo sapiens_hsa020100.95245591
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94226601
93Metabolic pathways_Homo sapiens_hsa011000.91772909
94ErbB signaling pathway_Homo sapiens_hsa040120.91128112
95Insulin resistance_Homo sapiens_hsa049310.90789303
96mTOR signaling pathway_Homo sapiens_hsa041500.89150973
97Complement and coagulation cascades_Homo sapiens_hsa046100.87072186
98Arginine biosynthesis_Homo sapiens_hsa002200.86856258
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86848682
100Pyruvate metabolism_Homo sapiens_hsa006200.86354000
101Caffeine metabolism_Homo sapiens_hsa002320.86070610
102Biosynthesis of amino acids_Homo sapiens_hsa012300.84976246
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84946524
104Leishmaniasis_Homo sapiens_hsa051400.84918799
105Hepatitis B_Homo sapiens_hsa051610.84808398
106N-Glycan biosynthesis_Homo sapiens_hsa005100.84072459
107Glioma_Homo sapiens_hsa052140.83628852
108GnRH signaling pathway_Homo sapiens_hsa049120.83258663
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82733927
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82589365
111Huntingtons disease_Homo sapiens_hsa050160.78345629
112Chemokine signaling pathway_Homo sapiens_hsa040620.78266679
113Other glycan degradation_Homo sapiens_hsa005110.77967402
114Carbon metabolism_Homo sapiens_hsa012000.75686750
115Staphylococcus aureus infection_Homo sapiens_hsa051500.75457437
116Endocytosis_Homo sapiens_hsa041440.73013626
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.72653449
118Fatty acid metabolism_Homo sapiens_hsa012120.72402501
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72114130
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.70820481
121Primary immunodeficiency_Homo sapiens_hsa053400.70132481
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69413776
123Starch and sucrose metabolism_Homo sapiens_hsa005000.69143547
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68202033
125RNA transport_Homo sapiens_hsa030130.67830552
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67417754
127Basal transcription factors_Homo sapiens_hsa030220.66994726
128Fat digestion and absorption_Homo sapiens_hsa049750.65189973
129FoxO signaling pathway_Homo sapiens_hsa040680.64591482
130Alzheimers disease_Homo sapiens_hsa050100.64508592
131Systemic lupus erythematosus_Homo sapiens_hsa053220.63993417
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63366740
133Collecting duct acid secretion_Homo sapiens_hsa049660.63167685
134RNA degradation_Homo sapiens_hsa030180.62590375
135NF-kappa B signaling pathway_Homo sapiens_hsa040640.62205180
136T cell receptor signaling pathway_Homo sapiens_hsa046600.61796793
137Toxoplasmosis_Homo sapiens_hsa051450.59874591
138Influenza A_Homo sapiens_hsa051640.59338511
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58199382
140Tyrosine metabolism_Homo sapiens_hsa003500.58182770
141Inositol phosphate metabolism_Homo sapiens_hsa005620.57833289
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57537587
143Estrogen signaling pathway_Homo sapiens_hsa049150.56777670
144Tuberculosis_Homo sapiens_hsa051520.56325039
145Prostate cancer_Homo sapiens_hsa052150.55895477
146TNF signaling pathway_Homo sapiens_hsa046680.55511350
147Leukocyte transendothelial migration_Homo sapiens_hsa046700.53879764
148Cell cycle_Homo sapiens_hsa041100.53395355
149MAPK signaling pathway_Homo sapiens_hsa040100.53177983
150Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52554680
151PPAR signaling pathway_Homo sapiens_hsa033200.50918164
152Choline metabolism in cancer_Homo sapiens_hsa052310.50893187
153Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50176077
154Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49786994
155Arachidonic acid metabolism_Homo sapiens_hsa005900.48255393
156Colorectal cancer_Homo sapiens_hsa052100.48113752
157Phenylalanine metabolism_Homo sapiens_hsa003600.48068409
158Proteoglycans in cancer_Homo sapiens_hsa052050.47612204
159Galactose metabolism_Homo sapiens_hsa000520.46940989
160AMPK signaling pathway_Homo sapiens_hsa041520.45058249
161Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44288329
162Linoleic acid metabolism_Homo sapiens_hsa005910.44154131
163Steroid biosynthesis_Homo sapiens_hsa001000.43927722
164Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42781057
165Shigellosis_Homo sapiens_hsa051310.42179782
166Regulation of autophagy_Homo sapiens_hsa041400.41755637
167Lysine degradation_Homo sapiens_hsa003100.41697780
168Sphingolipid metabolism_Homo sapiens_hsa006000.41280889
169Synaptic vesicle cycle_Homo sapiens_hsa047210.41099665
170HIF-1 signaling pathway_Homo sapiens_hsa040660.40735395
171Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39836241
172Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39260261
173Small cell lung cancer_Homo sapiens_hsa052220.38377884
174HTLV-I infection_Homo sapiens_hsa051660.36282414
1752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36058051
176Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35723434
177RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35033000
178Fructose and mannose metabolism_Homo sapiens_hsa000510.34851731
179Hematopoietic cell lineage_Homo sapiens_hsa046400.34768521

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