STK17A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.91333774
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.91333774
3positive regulation of gamma-delta T cell activation (GO:0046645)4.87755228
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.65340146
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.53644328
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45574582
7positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28363856
8antigen processing and presentation of endogenous antigen (GO:0019883)4.25895067
9regulation of B cell receptor signaling pathway (GO:0050855)4.23597437
10negative T cell selection (GO:0043383)4.16258817
11negative thymic T cell selection (GO:0045060)4.12276511
12response to interleukin-15 (GO:0070672)3.80121389
13cellular response to interleukin-15 (GO:0071350)3.62571005
14T cell migration (GO:0072678)3.58651112
15leukocyte aggregation (GO:0070486)3.44679062
16regulation of gamma-delta T cell activation (GO:0046643)3.44522809
17tolerance induction (GO:0002507)3.41187078
18type I interferon signaling pathway (GO:0060337)3.40911841
19cellular response to type I interferon (GO:0071357)3.40911841
20response to type I interferon (GO:0034340)3.38262081
21regulation of alpha-beta T cell proliferation (GO:0046640)3.36601746
22NIK/NF-kappaB signaling (GO:0038061)3.36159809
23regulation of gamma-delta T cell differentiation (GO:0045586)3.34636133
24response to muramyl dipeptide (GO:0032495)3.31712595
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.29391269
26positive T cell selection (GO:0043368)3.28405193
27modulation by symbiont of host immune response (GO:0052553)3.28067742
28positive regulation by symbiont of host defense response (GO:0052509)3.28067742
29modulation by symbiont of host defense response (GO:0052031)3.28067742
30modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.28067742
31modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.28067742
32positive regulation by organism of defense response of other organism involved in symbiotic interact3.28067742
33B cell receptor signaling pathway (GO:0050853)3.26809411
34positive thymic T cell selection (GO:0045059)3.25657426
35thymic T cell selection (GO:0045061)3.24126833
36T cell selection (GO:0045058)3.24028444
37negative regulation of T cell mediated immunity (GO:0002710)3.18084335
38myeloid dendritic cell differentiation (GO:0043011)3.17906999
39regulation of T cell tolerance induction (GO:0002664)3.13891653
40hypotonic response (GO:0006971)3.00991100
41negative regulation of interleukin-12 production (GO:0032695)2.98248409
42regulation of interleukin-12 biosynthetic process (GO:0045075)2.94055265
43hemidesmosome assembly (GO:0031581)2.92462734
44detection of other organism (GO:0098543)2.92380797
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91245959
46myeloid dendritic cell activation (GO:0001773)2.90383846
47positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89824943
48positive regulation of macrophage differentiation (GO:0045651)2.89403231
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85500202
50regulation of T-helper 1 cell differentiation (GO:0045625)2.84051555
51regulation of interferon-beta biosynthetic process (GO:0045357)2.84010641
52interferon-gamma production (GO:0032609)2.83462432
53regulation of necroptotic process (GO:0060544)2.82948320
54germinal center formation (GO:0002467)2.82662803
55negative regulation of lymphocyte mediated immunity (GO:0002707)2.81113507
56regulation of T cell mediated cytotoxicity (GO:0001914)2.80282973
57neutrophil activation involved in immune response (GO:0002283)2.79094712
58regulation of type I interferon-mediated signaling pathway (GO:0060338)2.78576612
59regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77443377
60regulation of natural killer cell mediated immunity (GO:0002715)2.77443377
61macrophage activation involved in immune response (GO:0002281)2.77164997
62hepatocyte apoptotic process (GO:0097284)2.76254110
63detection of bacterium (GO:0016045)2.74052498
64cellular extravasation (GO:0045123)2.73538929
65regulation of B cell differentiation (GO:0045577)2.73093355
66positive regulation of tolerance induction (GO:0002645)2.72534644
67* regulation of fibroblast apoptotic process (GO:2000269)2.72515494
68regulation of tolerance induction (GO:0002643)2.72341799
69lipopolysaccharide-mediated signaling pathway (GO:0031663)2.72312942
70interferon-gamma-mediated signaling pathway (GO:0060333)2.72241065
71B cell homeostasis (GO:0001782)2.71414379
72positive regulation of B cell differentiation (GO:0045579)2.68262107
73T cell receptor signaling pathway (GO:0050852)2.68018054
74positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67839344
75positive regulation of granulocyte differentiation (GO:0030854)2.67500826
76antigen receptor-mediated signaling pathway (GO:0050851)2.67240340
77regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.66497179
78regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65472557
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.65180857
80detection of molecule of bacterial origin (GO:0032490)2.61921857
81positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.61573678
82positive regulation of interleukin-2 production (GO:0032743)2.61562902
83positive regulation of isotype switching (GO:0045830)2.60297062
84regulation of regulatory T cell differentiation (GO:0045589)2.59571992
85detection of external biotic stimulus (GO:0098581)2.58607435
86antigen processing and presentation via MHC class Ib (GO:0002475)2.58015292
87regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.57563499
88B cell proliferation (GO:0042100)2.57237131
89response to laminar fluid shear stress (GO:0034616)2.57089105
90response to peptidoglycan (GO:0032494)2.56104575
91defense response to protozoan (GO:0042832)2.55991468
92membrane raft organization (GO:0031579)2.55495203
93T cell costimulation (GO:0031295)2.55050763
94negative regulation of B cell proliferation (GO:0030889)2.54767507
95negative regulation of leukocyte mediated immunity (GO:0002704)2.53405996
96cellular response to virus (GO:0098586)2.52692259
97negative regulation of T-helper cell differentiation (GO:0045623)2.51700703
98negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.51700703
99regulation of leukocyte mediated cytotoxicity (GO:0001910)2.51335031
100lymphocyte costimulation (GO:0031294)2.50246816

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.09848961
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.58696850
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.58275202
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.04488108
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.34464498
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33063706
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.07885845
8MYB_21317192_ChIP-Seq_ERMYB_Mouse3.03326269
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96344033
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.94032901
11RUNX_20019798_ChIP-Seq_JUKART_Human2.85545051
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81892872
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79351861
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.78870540
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.75031428
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.64267514
17* MYB_26560356_Chip-Seq_TH2_Human2.55187693
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.54615286
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48345365
20RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.43044008
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.42548069
22MAF_26560356_Chip-Seq_TH1_Human2.33570534
23MYC_22102868_ChIP-Seq_BL_Human2.27928421
24SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20877163
25MYB_26560356_Chip-Seq_TH1_Human2.20556789
26BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08578074
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95837233
28SPI1_23547873_ChIP-Seq_NB4_Human1.89772093
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86978934
30RUNX1_22412390_ChIP-Seq_EML_Mouse1.80031658
31UTX_26944678_Chip-Seq_JUKART_Human1.77999422
32TCF7_22412390_ChIP-Seq_EML_Mouse1.74971006
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73448465
34VDR_24763502_ChIP-Seq_THP-1_Human1.71477343
35VDR_21846776_ChIP-Seq_THP-1_Human1.69363565
36* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.65654507
37* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.65654507
38STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65627863
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.64849337
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62041946
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.61210204
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58193374
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.57127116
44GATA3_27048872_Chip-Seq_THYMUS_Human1.55173631
45MAF_26560356_Chip-Seq_TH2_Human1.54764610
46NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53900233
47* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52563886
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51753977
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51632092
50KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48453385
51SPI1_23127762_ChIP-Seq_K562_Human1.48151915
52SCL_19346495_ChIP-Seq_HPC-7_Human1.47644597
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46947304
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45964148
55* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39643590
56PU_27001747_Chip-Seq_BMDM_Mouse1.38283990
57GATA1_22025678_ChIP-Seq_K562_Human1.35394705
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32098073
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.32029736
60VDR_24787735_ChIP-Seq_THP-1_Human1.31976485
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29413122
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29172438
63JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25875458
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.25806152
65KDM2B_26808549_Chip-Seq_DND41_Human1.25739047
66GATA1_19941826_ChIP-Seq_K562_Human1.25359307
67* GATA3_26560356_Chip-Seq_TH2_Human1.21565977
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19851406
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18622444
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14487668
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.14051257
72RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13307375
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.13298352
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.10531327
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09584358
76PPAR_26484153_Chip-Seq_NCI-H1993_Human1.09499632
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07610291
78* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06705555
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05829794
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04628523
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04129593
82ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03990992
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.01600152
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01410287
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00980898
86UBF1/2_26484160_Chip-Seq_HMECs_Human0.98050776
87* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97159410
88GATA2_19941826_ChIP-Seq_K562_Human0.96559035
89ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95846240
90ATF3_27146783_Chip-Seq_COLON_Human0.95217713
91* BRD4_25478319_ChIP-Seq_HGPS_Human0.94210868
92TFEB_21752829_ChIP-Seq_HELA_Human0.93914516
93GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90312385
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90108230
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89283667
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88480585
97P300_27058665_Chip-Seq_ZR-75-30cells_Human0.88360741
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86266708
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86259860
100PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85116199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.47456584
2MP0003763_abnormal_thymus_physiology3.31939110
3MP0001835_abnormal_antigen_presentation3.07516083
4MP0000685_abnormal_immune_system2.91085758
5MP0005671_abnormal_response_to2.87804679
6MP0003303_peritoneal_inflammation2.83797922
7MP0003300_gastrointestinal_ulcer2.79273631
8MP0003724_increased_susceptibility_to2.77252625
9MP0005000_abnormal_immune_tolerance2.71361341
10MP0001800_abnormal_humoral_immune2.65997084
11MP0005387_immune_system_phenotype2.52843112
12MP0001790_abnormal_immune_system2.52843112
13MP0002723_abnormal_immune_serum2.30920189
14MP0009785_altered_susceptibility_to2.30213429
15MP0002452_abnormal_antigen_presenting2.26460544
16MP0002420_abnormal_adaptive_immunity2.18254539
17MP0004947_skin_inflammation2.18009079
18MP0001819_abnormal_immune_cell2.14837809
19MP0002419_abnormal_innate_immunity2.12817677
20MP0005025_abnormal_response_to2.09872765
21MP0002148_abnormal_hypersensitivity_rea2.03539636
22MP0009333_abnormal_splenocyte_physiolog2.00996991
23MP0002405_respiratory_system_inflammati1.98674974
24MP0002398_abnormal_bone_marrow1.95040104
25MP0005451_abnormal_body_composition1.88837894
26MP0003656_abnormal_erythrocyte_physiolo1.85979392
27MP0010155_abnormal_intestine_physiology1.84814591
28MP0008260_abnormal_autophagy1.84617296
29MP0003191_abnormal_cellular_cholesterol1.84225852
30MP0000716_abnormal_immune_system1.78687800
31MP0002166_altered_tumor_susceptibility1.77338990
32MP0001533_abnormal_skeleton_physiology1.73155181
33MP0000858_altered_metastatic_potential1.70952840
34MP0003091_abnormal_cell_migration1.69925450
35MP0003566_abnormal_cell_adhesion1.69356463
36MP0002877_abnormal_melanocyte_morpholog1.68413657
37MP0005464_abnormal_platelet_physiology1.66532170
38MP0006082_CNS_inflammation1.65928474
39MP0002722_abnormal_immune_system1.58358706
40MP0000703_abnormal_thymus_morphology1.55769690
41MP0003828_pulmonary_edema1.54596683
42MP0001853_heart_inflammation1.54134424
43MP0003705_abnormal_hypodermis_morpholog1.53402522
44MP0000689_abnormal_spleen_morphology1.52548058
45MP0004510_myositis1.49514209
46MP0001845_abnormal_inflammatory_respons1.47583964
47MP0002429_abnormal_blood_cell1.47163435
48MP0008438_abnormal_cutaneous_collagen1.43941953
49MP0002006_tumorigenesis1.41279359
50MP0005310_abnormal_salivary_gland1.38143637
51MP0003453_abnormal_keratinocyte_physiol1.37348106
52MP0001851_eye_inflammation1.35338247
53MP0005023_abnormal_wound_healing1.33428562
54MP0009764_decreased_sensitivity_to1.33049130
55MP0002998_abnormal_bone_remodeling1.29327708
56MP0003448_altered_tumor_morphology1.27860168
57MP0002933_joint_inflammation1.25771992
58MP0005164_abnormal_response_to1.25757234
59MP0002396_abnormal_hematopoietic_system1.18350200
60MP0009840_abnormal_foam_cell1.17861503
61MP0000465_gastrointestinal_hemorrhage1.15850205
62MP0001873_stomach_inflammation1.13908798
63MP0002009_preneoplasia1.13785323
64MP0010352_gastrointestinal_tract_polyps1.12744781
65MP0004808_abnormal_hematopoietic_stem1.12460716
66MP0008469_abnormal_protein_level1.11674870
67MP0004883_abnormal_blood_vessel1.11008798
68MP0003045_fibrosis1.08386428
69MP0004381_abnormal_hair_follicle1.04919192
70MP0003866_abnormal_defecation1.02409808
71MP0001958_emphysema1.01197787
72MP0001216_abnormal_epidermal_layer0.98660295
73MP0002060_abnormal_skin_morphology0.98557518
74MP0003950_abnormal_plasma_membrane0.98340332
75MP0001348_abnormal_lacrimal_gland0.95942698
76MP0006054_spinal_hemorrhage0.90938459
77MP0005076_abnormal_cell_differentiation0.88860685
78MP0005621_abnormal_cell_physiology0.85401748
79MP0005390_skeleton_phenotype0.84841367
80MP0009763_increased_sensitivity_to0.84671154
81MP0000569_abnormal_digit_pigmentation0.84272646
82MP0000249_abnormal_blood_vessel0.84228947
83MP0008057_abnormal_DNA_replication0.82845011
84MP0003279_aneurysm0.82138252
85MP0000343_altered_response_to0.81304031
86MP0000490_abnormal_crypts_of0.80892904
87MP0003795_abnormal_bone_structure0.79510955
88MP0001545_abnormal_hematopoietic_system0.78636572
89MP0005397_hematopoietic_system_phenotyp0.78636572
90MP0002019_abnormal_tumor_incidence0.76810114
91MP0001849_ear_inflammation0.75510093
92MP0005275_abnormal_skin_tensile0.75224785
93MP0002138_abnormal_hepatobiliary_system0.74569135
94MP0003183_abnormal_peptide_metabolism0.74350341
95MP0002332_abnormal_exercise_endurance0.73105752
96MP0004185_abnormal_adipocyte_glucose0.72952002
97MP0000767_abnormal_smooth_muscle0.72362859
98MP0005058_abnormal_lysosome_morphology0.72053419
99MP0009278_abnormal_bone_marrow0.71688962
100MP0001542_abnormal_bone_strength0.70014632

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.27551549
2Abnormality of T cell number (HP:0011839)4.01838328
3Eczematoid dermatitis (HP:0000976)4.01357555
4Pustule (HP:0200039)3.51594317
5Recurrent bacterial skin infections (HP:0005406)3.51507033
6Elevated erythrocyte sedimentation rate (HP:0003565)3.40606415
7Myositis (HP:0100614)3.28804679
8Recurrent viral infections (HP:0004429)3.25188203
9Recurrent abscess formation (HP:0002722)3.18511256
10Abnormality of T cells (HP:0002843)3.15250826
11Abnormal delayed hypersensitivity skin test (HP:0002963)3.12610159
12Orchitis (HP:0100796)3.08147576
13Milia (HP:0001056)3.04340916
14Recurrent fungal infections (HP:0002841)3.04283008
15Vasculitis (HP:0002633)3.03108102
16Mediastinal lymphadenopathy (HP:0100721)2.99185941
17Gastrointestinal infarctions (HP:0005244)2.96557108
18Abnormality of macrophages (HP:0004311)2.93146559
19Autoimmune hemolytic anemia (HP:0001890)2.92883809
20Optic neuritis (HP:0100653)2.84530211
21Retrobulbar optic neuritis (HP:0100654)2.84530211
22Stomatitis (HP:0010280)2.79864557
23Gastrointestinal stroma tumor (HP:0100723)2.77691997
24Recurrent bronchitis (HP:0002837)2.75415365
25Subacute progressive viral hepatitis (HP:0006572)2.73821057
26Chronic mucocutaneous candidiasis (HP:0002728)2.72062282
27Recurrent cutaneous fungal infections (HP:0011370)2.72062282
28Lymphopenia (HP:0001888)2.68185896
29Pulmonary infiltrates (HP:0002113)2.67921336
30Thick nail (HP:0001805)2.66838004
31Meningitis (HP:0001287)2.65173913
32Cellulitis (HP:0100658)2.61789417
33Abnormality of cells of the lymphoid lineage (HP:0012140)2.58889086
34Recurrent skin infections (HP:0001581)2.57366913
35IgA deficiency (HP:0002720)2.55808825
36Inflammation of the large intestine (HP:0002037)2.52628272
37Spontaneous hematomas (HP:0007420)2.50884266
38Spondylolisthesis (HP:0003302)2.47021044
39Abnormality of T cell physiology (HP:0011840)2.46391472
40Increased IgM level (HP:0003496)2.42622356
41Gastrointestinal inflammation (HP:0004386)2.41366161
42Viral hepatitis (HP:0006562)2.40675448
43Keratoconjunctivitis sicca (HP:0001097)2.37291173
44Chronic diarrhea (HP:0002028)2.35925923
45Leukocytosis (HP:0001974)2.35623553
46Agammaglobulinemia (HP:0004432)2.35539675
47Encephalitis (HP:0002383)2.34552790
48Gingivitis (HP:0000230)2.33917952
49IgG deficiency (HP:0004315)2.32868886
50Granulocytopenia (HP:0001913)2.30883623
51Verrucae (HP:0200043)2.30178683
52Papilloma (HP:0012740)2.30178683
53Atrophic scars (HP:0001075)2.28865476
54Onycholysis (HP:0001806)2.26661752
55Fatigue (HP:0012378)2.26114327
56Interstitial pulmonary disease (HP:0006530)2.24873572
57Eosinophilia (HP:0001880)2.24583822
58Urticaria (HP:0001025)2.23670282
59Colitis (HP:0002583)2.22709669
60Panhypogammaglobulinemia (HP:0003139)2.22562162
61Emphysema (HP:0002097)2.19634969
62Autoimmune thrombocytopenia (HP:0001973)2.18436727
63Increased IgE level (HP:0003212)2.16206835
64Chest pain (HP:0100749)2.16048085
65Severe combined immunodeficiency (HP:0004430)2.15694120
66Glomerulopathy (HP:0100820)2.14617922
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14298620
68Abnormality of eosinophils (HP:0001879)2.13456616
69Keratoconjunctivitis (HP:0001096)2.12375042
70Obstructive lung disease (HP:0006536)2.11811098
71Chronic obstructive pulmonary disease (HP:0006510)2.11811098
72Osteolytic defects of the hand bones (HP:0009699)2.11261758
73Osteolytic defects of the phalanges of the hand (HP:0009771)2.11261758
74Epistaxis (HP:0000421)2.10220963
75Gingival bleeding (HP:0000225)2.06337740
76Spinal cord lesions (HP:0100561)2.05890666
77Syringomyelia (HP:0003396)2.05890666
78Peritonitis (HP:0002586)2.04803208
79Skin ulcer (HP:0200042)2.03087530
80Osteomyelitis (HP:0002754)2.02972009
81Arterial tortuosity (HP:0005116)1.97758063
82Prolonged bleeding time (HP:0003010)1.91366981
83Hypergammaglobulinemia (HP:0010702)1.90675245
84Vertebral compression fractures (HP:0002953)1.90603773
85Dilatation of the ascending aorta (HP:0005111)1.90399285
86IgM deficiency (HP:0002850)1.88127950
87Hemoptysis (HP:0002105)1.88040036
88Lymphoma (HP:0002665)1.87418979
89Abnormality of nail color (HP:0100643)1.86850887
90Abnormal platelet volume (HP:0011876)1.86766027
91Premature loss of primary teeth (HP:0006323)1.86630491
92Combined immunodeficiency (HP:0005387)1.86490110
93Vascular tortuosity (HP:0004948)1.84462771
94Restrictive lung disease (HP:0002091)1.83019901
95Ridged nail (HP:0001807)1.82721640
96Slow saccadic eye movements (HP:0000514)1.81720362
97Recurrent gram-negative bacterial infections (HP:0005420)1.80467040
98Persistence of primary teeth (HP:0006335)1.79862155
99Abnormal blistering of the skin (HP:0008066)1.79741518
100Periodontitis (HP:0000704)1.79584277

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.28995924
2MAP4K13.24545236
3MAP3K143.17412482
4TXK2.90977720
5ERN12.49814839
6IKBKE2.21714385
7RIPK42.12514916
8IRAK42.10378527
9JAK32.09019274
10TYK22.02571378
11CSK2.00609609
12MAP2K32.00270824
13ZAP701.99697560
14JAK11.99687915
15IRAK31.86383212
16MAP3K31.82662129
17BLK1.73208932
18TBK11.70806601
19MAP3K131.70515471
20BTK1.70052113
21TGFBR21.61651285
22IKBKB1.55776733
23GRK61.52891380
24NEK91.49180923
25STK101.48643208
26EPHB11.48155331
27SYK1.45272571
28TAOK21.42932253
29SIK31.42776350
30IRAK11.34624992
31CDK121.34610995
32BMPR21.34588128
33ITK1.33629483
34FES1.27179602
35HCK1.23236474
36FGFR41.18536838
37LCK1.17003438
38MAP3K101.16311671
39FGFR31.10495216
40IRAK21.07399685
41TAOK11.06579484
42MOS1.06077803
43TEC1.03314876
44CSF1R1.01806792
45PDGFRA1.01277521
46MST1R0.98608555
47LATS10.95205607
48PIM10.95053996
49LYN0.93276054
50PDGFRB0.91116391
51CAMKK20.90988672
52TESK20.90599892
53SIK20.89424735
54TTN0.89253752
55MAP3K10.88993599
56TRPM70.88738519
57CDC42BPA0.88187574
58MARK30.88039679
59MELK0.87562601
60FGR0.86821066
61MAPK110.83344947
62CLK10.82908082
63SCYL20.82261794
64GRK70.82170356
65RIPK10.82070207
66CDK60.81257338
67NME20.80616413
68SIK10.80403263
69CHUK0.76887496
70TRIB30.76574363
71JAK20.76516152
72HIPK20.76440559
73WNK10.75217581
74TAOK30.74683398
75CDK40.72194251
76SMG10.66067935
77KSR20.64252266
78PIK3CG0.63724685
79PRKD20.62558086
80LMTK20.60798024
81PTK2B0.56171855
82MAP3K20.54723655
83PRKCQ0.54408669
84STK40.53269560
85PAK40.52211112
86MAPKAPK20.51501793
87PDK10.50025052
88NLK0.49883891
89YES10.48149142
90STK380.46094330
91BMX0.46013463
92MAP3K80.45549308
93MAP3K50.44756892
94MAP3K110.44711736
95MAPK70.44629361
96KIT0.42991470
97SGK30.40325821
98BRD40.40276466
99PTK60.40192301
100EPHA20.40110487

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.70734139
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.40402196
3Osteoclast differentiation_Homo sapiens_hsa043802.25163074
4B cell receptor signaling pathway_Homo sapiens_hsa046622.16253227
5Leishmaniasis_Homo sapiens_hsa051402.14516787
6T cell receptor signaling pathway_Homo sapiens_hsa046602.09910907
7Allograft rejection_Homo sapiens_hsa053302.08894091
8Measles_Homo sapiens_hsa051622.06609779
9Graft-versus-host disease_Homo sapiens_hsa053322.05842498
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.02266595
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.95106585
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94482297
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.94436250
14TNF signaling pathway_Homo sapiens_hsa046681.85762032
15Autoimmune thyroid disease_Homo sapiens_hsa053201.83513526
16Malaria_Homo sapiens_hsa051441.82797028
17Toxoplasmosis_Homo sapiens_hsa051451.81454512
18Hematopoietic cell lineage_Homo sapiens_hsa046401.67272776
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65124810
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.63422378
21Influenza A_Homo sapiens_hsa051641.61481556
22Pancreatic cancer_Homo sapiens_hsa052121.57621132
23Antigen processing and presentation_Homo sapiens_hsa046121.57542963
24Acute myeloid leukemia_Homo sapiens_hsa052211.55537676
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52623660
26Herpes simplex infection_Homo sapiens_hsa051681.52419094
27Chronic myeloid leukemia_Homo sapiens_hsa052201.51595202
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.51585779
29Hepatitis B_Homo sapiens_hsa051611.50190058
30Viral myocarditis_Homo sapiens_hsa054161.50129497
31Non-small cell lung cancer_Homo sapiens_hsa052231.46837542
32Tuberculosis_Homo sapiens_hsa051521.40849295
33Small cell lung cancer_Homo sapiens_hsa052221.39990486
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39939858
35Apoptosis_Homo sapiens_hsa042101.39071875
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32627931
37Shigellosis_Homo sapiens_hsa051311.31882202
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26477295
39Hepatitis C_Homo sapiens_hsa051601.22334008
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.20765504
41Viral carcinogenesis_Homo sapiens_hsa052031.17336958
42Type I diabetes mellitus_Homo sapiens_hsa049401.15530038
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.15015219
44Renal cell carcinoma_Homo sapiens_hsa052111.14446770
45Chemokine signaling pathway_Homo sapiens_hsa040621.13671614
46Staphylococcus aureus infection_Homo sapiens_hsa051501.13051289
47Legionellosis_Homo sapiens_hsa051341.11106623
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.11027666
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06428000
50African trypanosomiasis_Homo sapiens_hsa051431.03356430
51VEGF signaling pathway_Homo sapiens_hsa043701.01448199
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01359650
53HTLV-I infection_Homo sapiens_hsa051660.99564657
54Asthma_Homo sapiens_hsa053100.99107819
55Epstein-Barr virus infection_Homo sapiens_hsa051690.97770043
56Rheumatoid arthritis_Homo sapiens_hsa053230.91106049
57Other glycan degradation_Homo sapiens_hsa005110.90920717
58Prolactin signaling pathway_Homo sapiens_hsa049170.90912085
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.90537703
60Pertussis_Homo sapiens_hsa051330.90322540
61Platelet activation_Homo sapiens_hsa046110.87984642
62FoxO signaling pathway_Homo sapiens_hsa040680.87236294
63Prostate cancer_Homo sapiens_hsa052150.83892236
64Bladder cancer_Homo sapiens_hsa052190.83691795
65Focal adhesion_Homo sapiens_hsa045100.83340747
66Endometrial cancer_Homo sapiens_hsa052130.81613695
67Amoebiasis_Homo sapiens_hsa051460.81196371
68Salmonella infection_Homo sapiens_hsa051320.80975726
69Colorectal cancer_Homo sapiens_hsa052100.80239588
70Proteoglycans in cancer_Homo sapiens_hsa052050.77609158
71Endocytosis_Homo sapiens_hsa041440.75415191
72MicroRNAs in cancer_Homo sapiens_hsa052060.74057667
73p53 signaling pathway_Homo sapiens_hsa041150.73477603
74Dorso-ventral axis formation_Homo sapiens_hsa043200.68275245
75Phagosome_Homo sapiens_hsa041450.66276142
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66264991
77ErbB signaling pathway_Homo sapiens_hsa040120.65560401
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65448279
79Systemic lupus erythematosus_Homo sapiens_hsa053220.64343705
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63663465
81Glioma_Homo sapiens_hsa052140.63516446
82mTOR signaling pathway_Homo sapiens_hsa041500.62573276
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.60540113
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59529728
85Inositol phosphate metabolism_Homo sapiens_hsa005620.58550725
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.57548106
87MAPK signaling pathway_Homo sapiens_hsa040100.53873120
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53288407
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53055743
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52769923
91HIF-1 signaling pathway_Homo sapiens_hsa040660.51936050
92ECM-receptor interaction_Homo sapiens_hsa045120.49668811
93Pathways in cancer_Homo sapiens_hsa052000.49536369
94Lysosome_Homo sapiens_hsa041420.47836040
95Insulin resistance_Homo sapiens_hsa049310.47254023
96Thyroid cancer_Homo sapiens_hsa052160.47068379
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.45886311
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.44558117
99Choline metabolism in cancer_Homo sapiens_hsa052310.44002092
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42269713

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