STK17B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.14818818
2negative T cell selection (GO:0043383)5.92359461
3negative thymic T cell selection (GO:0045060)5.85307885
4negative regulation of cell killing (GO:0031342)5.54716303
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.54716303
6regulation of B cell receptor signaling pathway (GO:0050855)5.49606990
7positive thymic T cell selection (GO:0045059)5.47388614
8antigen processing and presentation of endogenous antigen (GO:0019883)5.41677916
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.41286344
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.41286344
11leukocyte aggregation (GO:0070486)5.26576051
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.23786971
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.23290087
14tolerance induction (GO:0002507)5.13717056
15regulation of gamma-delta T cell differentiation (GO:0045586)5.10523138
16cellular response to interleukin-15 (GO:0071350)5.00924268
17response to interleukin-15 (GO:0070672)4.99895646
18thymic T cell selection (GO:0045061)4.94346109
19interferon-gamma production (GO:0032609)4.92956457
20positive T cell selection (GO:0043368)4.76063710
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.68765003
22regulation of gamma-delta T cell activation (GO:0046643)4.68457729
23T cell selection (GO:0045058)4.63391761
24regulation of T cell tolerance induction (GO:0002664)4.44711038
25T cell migration (GO:0072678)4.41389993
26regulation of interleukin-12 biosynthetic process (GO:0045075)4.37626618
27regulation of B cell differentiation (GO:0045577)4.35809679
28negative regulation of T cell mediated immunity (GO:0002710)4.25898748
29B cell receptor signaling pathway (GO:0050853)4.21315330
30regulation of isotype switching to IgG isotypes (GO:0048302)4.20571288
31cytidine metabolic process (GO:0046087)4.09163995
32cytidine catabolic process (GO:0006216)4.09163995
33cytidine deamination (GO:0009972)4.09163995
34T cell costimulation (GO:0031295)3.99030436
35lymphocyte costimulation (GO:0031294)3.97737797
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.97408056
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.95346903
38regulation of alpha-beta T cell proliferation (GO:0046640)3.92915711
39antigen receptor-mediated signaling pathway (GO:0050851)3.86458649
40T cell receptor signaling pathway (GO:0050852)3.84410475
41positive regulation of B cell differentiation (GO:0045579)3.84177516
42negative regulation of B cell proliferation (GO:0030889)3.77689033
43NIK/NF-kappaB signaling (GO:0038061)3.72955525
44positive regulation of interleukin-2 production (GO:0032743)3.72412173
45negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.64454106
46negative regulation of lymphocyte mediated immunity (GO:0002707)3.63878967
47positive regulation of isotype switching (GO:0045830)3.60728204
48positive regulation of alpha-beta T cell proliferation (GO:0046641)3.58213066
49regulation of T cell mediated cytotoxicity (GO:0001914)3.54879886
50regulation of T cell receptor signaling pathway (GO:0050856)3.54751833
51positive regulation of granulocyte differentiation (GO:0030854)3.50624648
52Arp2/3 complex-mediated actin nucleation (GO:0034314)3.48603610
53positive regulation of T cell mediated cytotoxicity (GO:0001916)3.45209234
54regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.44775029
55regulation of regulatory T cell differentiation (GO:0045589)3.44692395
56mature B cell differentiation (GO:0002335)3.42621336
57positive regulation of tolerance induction (GO:0002645)3.42071685
58regulation of tolerance induction (GO:0002643)3.41222362
59dendritic cell migration (GO:0036336)3.40349203
60dendritic cell chemotaxis (GO:0002407)3.39083100
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.38903486
62regulation of natural killer cell mediated immunity (GO:0002715)3.38903486
63DNA deamination (GO:0045006)3.37477956
64leukocyte cell-cell adhesion (GO:0007159)3.35754246
65regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.35692559
66regulation of isotype switching (GO:0045191)3.34981461
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.34823267
68regulation of leukocyte mediated cytotoxicity (GO:0001910)3.33965746
69regulation of interleukin-2 biosynthetic process (GO:0045076)3.32388232
70regulation of B cell proliferation (GO:0030888)3.30871064
71negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.30271087
72positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.29950893
73negative regulation of leukocyte mediated immunity (GO:0002704)3.24397879
74positive regulation by organism of defense response of other organism involved in symbiotic interact3.24103032
75modulation by symbiont of host immune response (GO:0052553)3.24103032
76positive regulation by symbiont of host defense response (GO:0052509)3.24103032
77modulation by symbiont of host defense response (GO:0052031)3.24103032
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.24103032
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.24103032
80activated T cell proliferation (GO:0050798)3.20321440
81neutrophil activation involved in immune response (GO:0002283)3.19629038
82antigen processing and presentation via MHC class Ib (GO:0002475)3.19109125
83myeloid dendritic cell activation (GO:0001773)3.17030842
84granulocyte activation (GO:0036230)3.16063933
85regulation of chronic inflammatory response (GO:0002676)3.15776062
86positive regulation of natural killer cell mediated immunity (GO:0002717)3.11471616
87regulation of cell killing (GO:0031341)3.10911779
88positive regulation of DNA recombination (GO:0045911)3.10345121
89JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07705259
90myeloid cell activation involved in immune response (GO:0002275)3.07432468
91T-helper cell differentiation (GO:0042093)3.07331163
92CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.07331163
93B cell proliferation (GO:0042100)3.07288450
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.07042817
95negative regulation of adaptive immune response (GO:0002820)3.07008048
96cellular extravasation (GO:0045123)3.03686749
97regulation of B cell activation (GO:0050864)3.03398441
98immune response-activating cell surface receptor signaling pathway (GO:0002429)3.03339392
99positive regulation of cell killing (GO:0031343)3.03303632
100hepatocyte apoptotic process (GO:0097284)3.02957338
101negative regulation of interleukin-12 production (GO:0032695)3.02853517
102alpha-beta T cell activation (GO:0046631)3.02467613
103cellular response to zinc ion (GO:0071294)3.01326312
104leukocyte degranulation (GO:0043299)3.00772071
105mast cell activation (GO:0045576)3.00701266
106lymphocyte chemotaxis (GO:0048247)3.00649806
107T cell homeostasis (GO:0043029)2.98229818
108lymphocyte homeostasis (GO:0002260)2.97180816
109regulation of B cell mediated immunity (GO:0002712)2.95398696
110detection of other organism (GO:0098543)2.94830076
111regulation of immunoglobulin mediated immune response (GO:0002889)2.94027899
112myeloid dendritic cell differentiation (GO:0043011)2.93887971
113interferon-gamma-mediated signaling pathway (GO:0060333)2.93032340
114regulation of response to interferon-gamma (GO:0060330)2.92708525
115regulation of alpha-beta T cell activation (GO:0046634)2.92105869
116positive regulation of B cell activation (GO:0050871)2.91671669
117regulation of immunoglobulin production (GO:0002637)2.91500164
118positive regulation of immunoglobulin mediated immune response (GO:0002891)2.91201360
119positive regulation of B cell mediated immunity (GO:0002714)2.91201360
120positive regulation of B cell proliferation (GO:0030890)2.88402975
121regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.87518498
122immunoglobulin mediated immune response (GO:0016064)2.86823826
123alpha-beta T cell differentiation (GO:0046632)2.86654465
124macrophage activation involved in immune response (GO:0002281)2.86622796
125T cell proliferation (GO:0042098)2.85989592
126negative regulation of T cell apoptotic process (GO:0070233)2.84768235
127positive regulation of immunoglobulin production (GO:0002639)2.84671509
128lymphocyte migration (GO:0072676)2.84582837
129response to muramyl dipeptide (GO:0032495)2.83226284
130negative regulation of T cell receptor signaling pathway (GO:0050860)2.83190004
131negative regulation of B cell activation (GO:0050869)2.81941813
132CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.81240411
133mature B cell differentiation involved in immune response (GO:0002313)2.80804648
134neutrophil activation (GO:0042119)2.80670938
135T cell differentiation (GO:0030217)2.79998067
136B cell homeostasis (GO:0001782)2.78954506
137natural killer cell activation (GO:0030101)2.78855170
138T cell differentiation involved in immune response (GO:0002292)2.78810066
139alpha-beta T cell differentiation involved in immune response (GO:0002293)2.78810066
140alpha-beta T cell activation involved in immune response (GO:0002287)2.78810066
141defense response to protozoan (GO:0042832)2.78774243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.48837753
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.47157967
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.75029430
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.89781811
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.73962231
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.44287537
7* RUNX_20019798_ChIP-Seq_JUKART_Human3.34027018
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.29213822
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.26936824
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.17703759
11MYC_22102868_ChIP-Seq_BL_Human3.14716602
12E2F7_22180533_ChIP-Seq_HELA_Human3.14318707
13* MYB_26560356_Chip-Seq_TH2_Human3.09112167
14STAT4_19710469_ChIP-ChIP_TH1__Mouse3.06174879
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.05434954
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.90765585
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77703995
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.76375426
19MAF_26560356_Chip-Seq_TH1_Human2.74982771
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70889018
21MYB_26560356_Chip-Seq_TH1_Human2.63665215
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.55518217
23* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.43443040
24VDR_21846776_ChIP-Seq_THP-1_Human2.31297046
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.28330665
26SCL_19346495_ChIP-Seq_HPC-7_Human2.25491718
27* UTX_26944678_Chip-Seq_JUKART_Human2.25141114
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.17082070
29SPI1_23547873_ChIP-Seq_NB4_Human2.15798639
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.13535695
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12022359
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.03169188
33* ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.02264731
34* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95243339
35TCF7_22412390_ChIP-Seq_EML_Mouse1.91412275
36VDR_24763502_ChIP-Seq_THP-1_Human1.89155140
37* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87886698
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.87564879
39* GATA3_27048872_Chip-Seq_THYMUS_Human1.86175322
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71292993
41* MAF_26560356_Chip-Seq_TH2_Human1.66128286
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59525314
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.58823280
44* PU_27001747_Chip-Seq_BMDM_Mouse1.53866626
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53338889
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.52958493
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.52772490
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.47938113
49SPI1_23127762_ChIP-Seq_K562_Human1.47686271
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.43934613
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42007500
52TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41902328
53KDM2B_26808549_Chip-Seq_DND41_Human1.39787884
54* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35404295
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33276491
56* FOXM1_23109430_ChIP-Seq_U2OS_Human1.31356021
57* GATA3_26560356_Chip-Seq_TH2_Human1.27614935
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25035939
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23010243
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22644104
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.22365986
62STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22009266
63* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21947529
64* FLI1_27457419_Chip-Seq_LIVER_Mouse1.20860478
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16606292
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15125214
67GATA1_22025678_ChIP-Seq_K562_Human1.14582464
68PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14438622
69CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09408240
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08756300
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08183276
72ELK3_25401928_ChIP-Seq_HUVEC_Human1.07167890
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06514642
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04542732
75CIITA_25753668_ChIP-Seq_RAJI_Human1.04291942
76GATA2_21666600_ChIP-Seq_HMVEC_Human1.03343733
77VDR_24787735_ChIP-Seq_THP-1_Human0.98892962
78GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98394767
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97504415
80GATA3_26560356_Chip-Seq_TH1_Human0.96916208
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95479074
82VDR_23849224_ChIP-Seq_CD4+_Human0.94353519
83E2F4_17652178_ChIP-ChIP_JURKAT_Human0.93544138
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93045034
85GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92204133
86TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90532498
87* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89231154
88STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88515864
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87711200
90CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86549163
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86542494
92* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85746582
93* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85660287
94NCOR1_26117541_ChIP-Seq_K562_Human0.84108994
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82594221
96VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82568647
97* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82007258
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.81268440
99ELK1_19687146_ChIP-ChIP_HELA_Human0.80449175
100* NFE2_27457419_Chip-Seq_LIVER_Mouse0.79894764
101SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78404565
102* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78374277
103* EZH2_27294783_Chip-Seq_NPCs_Mouse0.77347580
104* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77233934
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.77037282
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.77008533
107* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76599348
108FOXP3_21729870_ChIP-Seq_TREG_Human0.76023858
109* GATA2_19941826_ChIP-Seq_K562_Human0.75929770
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75747698
111VDR_22108803_ChIP-Seq_LS180_Human0.75215355
112PRDM14_20953172_ChIP-Seq_ESCs_Human0.74024363
113GATA1_19941826_ChIP-Seq_K562_Human0.73984247
114FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70022780
115* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69216120
116* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.68143984
117GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.67384682
118TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.66899681
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.66877368
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.66008119
121SMRT_27268052_Chip-Seq_Bcells_Human0.65507292
122EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.65098431
123* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.64537982

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.07889377
2MP0003763_abnormal_thymus_physiology3.91823222
3MP0005671_abnormal_response_to3.91420880
4MP0000685_abnormal_immune_system3.42655750
5MP0001800_abnormal_humoral_immune3.41950402
6MP0001790_abnormal_immune_system3.33027312
7MP0005387_immune_system_phenotype3.33027312
8* MP0005000_abnormal_immune_tolerance2.98111975
9MP0002452_abnormal_antigen_presenting2.87291959
10MP0003436_decreased_susceptibility_to2.79862501
11MP0003303_peritoneal_inflammation2.79651118
12* MP0002723_abnormal_immune_serum2.77249029
13* MP0002420_abnormal_adaptive_immunity2.73628941
14MP0001873_stomach_inflammation2.72740754
15MP0002166_altered_tumor_susceptibility2.72150989
16* MP0001819_abnormal_immune_cell2.70794341
17MP0003300_gastrointestinal_ulcer2.63981544
18MP0009785_altered_susceptibility_to2.60307815
19* MP0002398_abnormal_bone_marrow2.51803680
20MP0001853_heart_inflammation2.46842858
21MP0005025_abnormal_response_to2.43130467
22MP0002405_respiratory_system_inflammati2.36459672
23* MP0000716_abnormal_immune_system2.29333846
24MP0002148_abnormal_hypersensitivity_rea2.29015848
25MP0002006_tumorigenesis2.20040324
26MP0002419_abnormal_innate_immunity2.19096483
27MP0004947_skin_inflammation2.14916902
28MP0009333_abnormal_splenocyte_physiolog2.10951999
29MP0000689_abnormal_spleen_morphology2.07309892
30MP0002396_abnormal_hematopoietic_system2.05330852
31MP0002722_abnormal_immune_system2.04016633
32MP0010155_abnormal_intestine_physiology2.02324061
33MP0004510_myositis1.99516864
34MP0000703_abnormal_thymus_morphology1.97745838
35MP0006082_CNS_inflammation1.96095297
36MP0003724_increased_susceptibility_to1.95437556
37* MP0002429_abnormal_blood_cell1.86294653
38MP0002933_joint_inflammation1.79172803
39MP0001845_abnormal_inflammatory_respons1.73500721
40MP0005464_abnormal_platelet_physiology1.69368536
41MP0003866_abnormal_defecation1.67347533
42MP0002009_preneoplasia1.66435496
43MP0004808_abnormal_hematopoietic_stem1.61812839
44MP0005310_abnormal_salivary_gland1.60587978
45MP0000465_gastrointestinal_hemorrhage1.57974729
46MP0010352_gastrointestinal_tract_polyps1.55723717
47MP0001533_abnormal_skeleton_physiology1.42248716
48MP0000858_altered_metastatic_potential1.39274840
49MP0003448_altered_tumor_morphology1.34686238
50MP0008057_abnormal_DNA_replication1.33001455
51MP0005397_hematopoietic_system_phenotyp1.29365803
52MP0001545_abnormal_hematopoietic_system1.29365803
53MP0002138_abnormal_hepatobiliary_system1.26514630
54MP0000490_abnormal_crypts_of1.26188334
55MP0009278_abnormal_bone_marrow1.23534084
56MP0008469_abnormal_protein_level1.11376605
57MP0000015_abnormal_ear_pigmentation1.07312214
58MP0003172_abnormal_lysosome_physiology1.06899084
59MP0002998_abnormal_bone_remodeling1.01536380
60MP0005076_abnormal_cell_differentiation1.00088983
61MP0001851_eye_inflammation0.99458626
62MP0002019_abnormal_tumor_incidence0.94425087
63MP0005023_abnormal_wound_healing0.93322743
64MP0004883_abnormal_blood_vessel0.91739359
65MP0003453_abnormal_keratinocyte_physiol0.91510042
66MP0003656_abnormal_erythrocyte_physiolo0.89485089
67MP0009764_decreased_sensitivity_to0.86680637
68MP0000343_altered_response_to0.83019444
69MP0003045_fibrosis0.82617097
70MP0005174_abnormal_tail_pigmentation0.81693227
71MP0008260_abnormal_autophagy0.79023812
72MP0003828_pulmonary_edema0.78536756
73MP0003252_abnormal_bile_duct0.76153419
74MP0003183_abnormal_peptide_metabolism0.76103233
75MP0002277_abnormal_respiratory_mucosa0.75808603
76MP0001919_abnormal_reproductive_system0.73371229
77MP0001663_abnormal_digestive_system0.72723233
78MP0002163_abnormal_gland_morphology0.70401041
79MP0003795_abnormal_bone_structure0.69487683
80MP0002132_abnormal_respiratory_system0.69470201
81MP0003091_abnormal_cell_migration0.67444907
82MP0001243_abnormal_dermal_layer0.67404629
83MP0009763_increased_sensitivity_to0.66333741
84MP0008007_abnormal_cellular_replicative0.66195311
85MP0003566_abnormal_cell_adhesion0.65874539
86MP0005164_abnormal_response_to0.65647255
87MP0003077_abnormal_cell_cycle0.65417182
88MP0000249_abnormal_blood_vessel0.65047204
89MP0005075_abnormal_melanosome_morpholog0.64626406
90MP0010307_abnormal_tumor_latency0.64580987
91MP0001348_abnormal_lacrimal_gland0.64507382
92MP0005390_skeleton_phenotype0.64489855
93MP0003075_altered_response_to0.62912961
94MP0001216_abnormal_epidermal_layer0.60935218
95MP0008877_abnormal_DNA_methylation0.60527647
96MP0004381_abnormal_hair_follicle0.60440562
97MP0002876_abnormal_thyroid_physiology0.60292558
98MP0001191_abnormal_skin_condition0.59855801
99MP0002136_abnormal_kidney_physiology0.59038660
100MP0005451_abnormal_body_composition0.59001829
101MP0006054_spinal_hemorrhage0.58970769
102MP0010234_abnormal_vibrissa_follicle0.58598528
103MP0003279_aneurysm0.57043759
104MP0000477_abnormal_intestine_morphology0.57011528
105MP0005166_decreased_susceptibility_to0.56641544
106MP0002877_abnormal_melanocyte_morpholog0.55413796
107MP0003786_premature_aging0.54790249
108MP0000569_abnormal_digit_pigmentation0.53619021
109MP0004484_altered_response_of0.53198854
110MP0001765_abnormal_ion_homeostasis0.52652534
111MP0004130_abnormal_muscle_cell0.52007555
112MP0005058_abnormal_lysosome_morphology0.48778225
113MP0008873_increased_physiological_sensi0.48417697
114MP0001986_abnormal_taste_sensitivity0.48235476
115MP0001501_abnormal_sleep_pattern0.47345762
116MP0003191_abnormal_cellular_cholesterol0.46914886
117MP0002693_abnormal_pancreas_physiology0.46894819
118MP0000367_abnormal_coat/_hair0.45387815
119MP0002254_reproductive_system_inflammat0.45353767
120MP0000609_abnormal_liver_physiology0.44730310
121MP0000372_irregular_coat_pigmentation0.44615155
122MP0009765_abnormal_xenobiotic_induced0.44587768
123MP0000604_amyloidosis0.44468139

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.99182384
2T lymphocytopenia (HP:0005403)4.89427460
3Abnormality of T cell number (HP:0011839)4.79412282
4IgM deficiency (HP:0002850)4.64488072
5Optic neuritis (HP:0100653)4.59408794
6Retrobulbar optic neuritis (HP:0100654)4.59408794
7Eczematoid dermatitis (HP:0000976)4.54018835
8Stomatitis (HP:0010280)4.50831958
9Recurrent bronchitis (HP:0002837)4.48979392
10Elevated erythrocyte sedimentation rate (HP:0003565)4.31238216
11Orchitis (HP:0100796)4.29576811
12Recurrent fungal infections (HP:0002841)4.17570869
13Recurrent abscess formation (HP:0002722)4.11864870
14Recurrent viral infections (HP:0004429)4.08696353
15Abnormality of T cells (HP:0002843)4.07579410
16Agammaglobulinemia (HP:0004432)3.94417291
17Vasculitis (HP:0002633)3.85254336
18Meningitis (HP:0001287)3.79919889
19Chronic otitis media (HP:0000389)3.73604835
20IgG deficiency (HP:0004315)3.71171655
21Panhypogammaglobulinemia (HP:0003139)3.69206155
22Recurrent bacterial skin infections (HP:0005406)3.63000154
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.59909159
24Severe combined immunodeficiency (HP:0004430)3.55224423
25Pulmonary infiltrates (HP:0002113)3.53616896
26Chronic obstructive pulmonary disease (HP:0006510)3.49819892
27Obstructive lung disease (HP:0006536)3.49819892
28Mediastinal lymphadenopathy (HP:0100721)3.47176333
29Chronic mucocutaneous candidiasis (HP:0002728)3.41059891
30Recurrent cutaneous fungal infections (HP:0011370)3.41059891
31Combined immunodeficiency (HP:0005387)3.39826617
32Lymphopenia (HP:0001888)3.38192809
33Abnormality of B cell number (HP:0010975)3.36333699
34B lymphocytopenia (HP:0010976)3.36333699
35Thyroiditis (HP:0100646)3.30436918
36Abnormality of T cell physiology (HP:0011840)3.30069792
37Inflammation of the large intestine (HP:0002037)3.28971085
38Recurrent sinusitis (HP:0011108)3.26979408
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.26908837
40Arterial thrombosis (HP:0004420)3.22964928
41Nasal polyposis (HP:0100582)3.22340371
42Gastrointestinal stroma tumor (HP:0100723)3.20631587
43Keratoconjunctivitis sicca (HP:0001097)3.18829553
44Hemoptysis (HP:0002105)3.18273886
45Spontaneous hematomas (HP:0007420)3.17074489
46IgA deficiency (HP:0002720)3.14097331
47Gastrointestinal inflammation (HP:0004386)3.13500353
48Encephalitis (HP:0002383)3.10390222
49Pustule (HP:0200039)3.08757288
50Autoimmune thrombocytopenia (HP:0001973)3.04730520
51Chronic diarrhea (HP:0002028)3.02054585
52Abnormality of the fingertips (HP:0001211)3.01361040
53Colitis (HP:0002583)2.99828755
54Cellulitis (HP:0100658)2.98572028
55Recurrent skin infections (HP:0001581)2.95415342
56Abnormality of the prostate (HP:0008775)2.94495178
57Keratoconjunctivitis (HP:0001096)2.87632697
58Abnormality of eosinophils (HP:0001879)2.84215250
59Abnormality of the nasal mucosa (HP:0000433)2.83987921
60Increased IgE level (HP:0003212)2.82392020
61Chest pain (HP:0100749)2.78837839
62Leukocytosis (HP:0001974)2.75670075
63Gastrointestinal infarctions (HP:0005244)2.71304360
64Eosinophilia (HP:0001880)2.70705815
65Papilloma (HP:0012740)2.70397756
66Verrucae (HP:0200043)2.70397756
67Autoimmune hemolytic anemia (HP:0001890)2.69218721
68Thrombocytosis (HP:0001894)2.64468887
69Stomach cancer (HP:0012126)2.63927492
70Pulmonary embolism (HP:0002204)2.63312038
71Increased IgM level (HP:0003496)2.61701803
72Anorexia (HP:0002039)2.61668492
73Lymphoma (HP:0002665)2.59047634
74Bronchitis (HP:0012387)2.53390063
75Emphysema (HP:0002097)2.51781228
76Hypoplasia of the thymus (HP:0000778)2.47275373
77Urticaria (HP:0001025)2.40935542
78Gangrene (HP:0100758)2.40606210
79Granulocytopenia (HP:0001913)2.36187335
80Alveolar cell carcinoma (HP:0006519)2.34425041
81Gingivitis (HP:0000230)2.33612345
82Neoplasm of the tracheobronchial system (HP:0100552)2.30186697
83Hematochezia (HP:0002573)2.27670245
84Restrictive lung disease (HP:0002091)2.26413623
85Epistaxis (HP:0000421)2.26357580
86Pulmonary fibrosis (HP:0002206)2.25469083
87Hypergammaglobulinemia (HP:0010702)2.23529592
88Keratitis (HP:0000491)2.23357006
89Abnormality of macrophages (HP:0004311)2.20689333
90Recurrent gram-negative bacterial infections (HP:0005420)2.18646817
91Hypoproteinemia (HP:0003075)2.18213935
92Osteomyelitis (HP:0002754)2.17856868
93Chronic sinusitis (HP:0011109)2.17742903
94Ureteral stenosis (HP:0000071)2.16648523
95Fatigue (HP:0012378)2.15191016
96Glomerulopathy (HP:0100820)2.14225973
97Periodontitis (HP:0000704)2.13798861
98Polyneuropathy (HP:0001271)2.12658998
99Petechiae (HP:0000967)2.12562310
100Amaurosis fugax (HP:0100576)2.11568348
101Prolonged bleeding time (HP:0003010)2.11209279
102Hypochromic anemia (HP:0001931)2.11020565
103Joint swelling (HP:0001386)2.10801679
104Skin rash (HP:0000988)2.10591487
105Skin ulcer (HP:0200042)2.08152097
106Gingival bleeding (HP:0000225)2.07935069
107Increased density of long bones (HP:0006392)2.07254495
108Ureteral obstruction (HP:0006000)2.05485323
109Abnormality of the pleura (HP:0002103)2.03657385
110Recurrent pneumonia (HP:0006532)2.03235655
111Papilledema (HP:0001085)2.02250717
112Interstitial pulmonary disease (HP:0006530)2.02040279
113Abnormal platelet volume (HP:0011876)2.00645368
114Thrombophlebitis (HP:0004418)1.96598272
115Vertigo (HP:0002321)1.91057813
116Acute hepatic failure (HP:0006554)1.90720863
117Arthralgia (HP:0002829)1.90362938
118Abnormality of the pericardium (HP:0001697)1.88577480
119Prostate neoplasm (HP:0100787)1.86373624
120Abnormality of the endocardium (HP:0004306)1.85224688
121Episodic fever (HP:0001954)1.82803975

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.08675595
2MAP4K15.35624349
3STK102.90902420
4ITK2.87722093
5JAK32.67287561
6MAP3K142.59606030
7TYK22.48135711
8ZAP702.43923822
9GRK62.24885503
10IKBKE2.16671017
11TEC2.12984901
12JAK12.09981046
13BTK1.98655785
14BLK1.98335377
15MST41.86171719
16BMPR21.83843600
17TBK11.81437251
18FGFR41.80659956
19IRAK41.78129632
20IKBKB1.77144032
21MAP3K101.74884102
22MAP3K131.74743963
23FGFR31.70898487
24LCK1.66719112
25SYK1.63332617
26CSK1.62952852
27LRRK21.54192412
28CAMKK21.51779864
29TGFBR21.49468051
30HCK1.47489844
31NLK1.43599119
32KIT1.40997928
33PIM11.32974545
34CSF1R1.29905192
35IRAK31.27103973
36CHUK1.25261811
37RPS6KA41.22927058
38FRK1.20111017
39MARK31.16575219
40EPHB11.14795341
41EEF2K1.13496128
42PRKCQ1.02052377
43CDK121.01914087
44ERN10.98331598
45LYN0.98140405
46MAP2K30.94390729
47RIPK40.93884886
48PRPF4B0.92081508
49JAK20.90001508
50EPHA30.87404359
51GRK70.84735865
52TESK20.82743563
53MAP2K20.81805037
54CLK10.81764650
55ACVR1B0.76030795
56KDR0.73784414
57FGR0.73514527
58FES0.72112232
59SIK30.71392235
60MATK0.70848436
61FLT30.66820568
62TAOK30.65132195
63CDK90.64945457
64IRAK20.62664332
65SIK20.60199972
66CDK60.60086931
67PIK3CA0.59791992
68MAP3K10.59354497
69ERBB30.59079617
70CDK40.58461230
71CAMKK10.57105656
72MELK0.57032685
73PRKCH0.55262229
74STK40.54676117
75TNK20.53699216
76GRK50.51621953
77NEK90.49718729
78PDK10.49473267
79TLK10.49027235
80STK240.48846683
81NEK60.46974595
82TRPM70.44331004
83IRAK10.44075318
84ADRBK20.43802082
85PDGFRB0.43618278
86MAP3K20.43191952
87HIPK20.43006211
88NME20.42449600
89EIF2AK30.42325091
90TTN0.42043852
91RPS6KA50.41185260
92MAPKAPK20.40626852
93PTK60.40577780
94NEK20.40511778
95MAP3K120.40467793
96SGK20.40356371
97PKN20.38039320
98FYN0.36508800
99MAP3K80.36388576
100INSR0.35724557
101BRD40.34815968
102PTK2B0.34807766
103NUAK10.34200812
104MAP3K70.34156963
105ABL10.33168082
106MAPK70.33076365
107SGK30.32008185
108MAPK110.31633046
109IGF1R0.31270350
110ALK0.31202134
111MAP2K60.30924946
112MAPK120.30904735
113MAP3K110.30457826
114DMPK0.30076240
115PIK3CG0.29725519
116MAPKAPK30.29043238
117YES10.28973528
118MAPK30.26885113
119TRIB30.25967330
120MAPK40.24749993
121EGFR0.23669874
122PIM20.23599111
123PRKCD0.23230772
124PRKD20.22618050
125MAP3K30.22255189
126RPS6KB20.21782225

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.42016571
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.18216424
3Allograft rejection_Homo sapiens_hsa053302.99898056
4T cell receptor signaling pathway_Homo sapiens_hsa046602.94677173
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.84312882
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.65560969
7B cell receptor signaling pathway_Homo sapiens_hsa046622.61032814
8Leishmaniasis_Homo sapiens_hsa051402.51986528
9Autoimmune thyroid disease_Homo sapiens_hsa053202.50733679
10Measles_Homo sapiens_hsa051622.40275951
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.35553824
12Graft-versus-host disease_Homo sapiens_hsa053322.34326677
13Antigen processing and presentation_Homo sapiens_hsa046122.31874229
14Osteoclast differentiation_Homo sapiens_hsa043802.26762893
15Hematopoietic cell lineage_Homo sapiens_hsa046402.12609529
16Asthma_Homo sapiens_hsa053101.92723797
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.68958531
18NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61157561
19Viral myocarditis_Homo sapiens_hsa054161.60279322
20Toxoplasmosis_Homo sapiens_hsa051451.60215136
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53537420
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53110158
23Herpes simplex infection_Homo sapiens_hsa051681.52159955
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.47813279
25Chemokine signaling pathway_Homo sapiens_hsa040621.45541056
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.41196918
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38234498
28TNF signaling pathway_Homo sapiens_hsa046681.33819819
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32959970
30Hepatitis B_Homo sapiens_hsa051611.32826248
31Shigellosis_Homo sapiens_hsa051311.31720677
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25469949
33Acute myeloid leukemia_Homo sapiens_hsa052211.25330451
34Apoptosis_Homo sapiens_hsa042101.25028899
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24889201
36Influenza A_Homo sapiens_hsa051641.24453194
37Malaria_Homo sapiens_hsa051441.22253616
38Staphylococcus aureus infection_Homo sapiens_hsa051501.17487131
39Tuberculosis_Homo sapiens_hsa051521.16184597
40Legionellosis_Homo sapiens_hsa051341.11258035
41Pancreatic cancer_Homo sapiens_hsa052121.07694618
42Epstein-Barr virus infection_Homo sapiens_hsa051691.06114058
43Platelet activation_Homo sapiens_hsa046111.02820975
44Chronic myeloid leukemia_Homo sapiens_hsa052201.02786328
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99507878
46Pertussis_Homo sapiens_hsa051330.97944917
47HTLV-I infection_Homo sapiens_hsa051660.95094114
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93550440
49Viral carcinogenesis_Homo sapiens_hsa052030.88793289
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87468660
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82162508
52Salmonella infection_Homo sapiens_hsa051320.81621534
53Hepatitis C_Homo sapiens_hsa051600.80154860
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76534481
55Small cell lung cancer_Homo sapiens_hsa052220.76406166
56p53 signaling pathway_Homo sapiens_hsa041150.75001397
57Colorectal cancer_Homo sapiens_hsa052100.73441922
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.72539951
59Prolactin signaling pathway_Homo sapiens_hsa049170.71261278
60Type I diabetes mellitus_Homo sapiens_hsa049400.71167233
61VEGF signaling pathway_Homo sapiens_hsa043700.70581230
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68643136
63Non-small cell lung cancer_Homo sapiens_hsa052230.63815249
64Dorso-ventral axis formation_Homo sapiens_hsa043200.63712204
65African trypanosomiasis_Homo sapiens_hsa051430.61961740
66FoxO signaling pathway_Homo sapiens_hsa040680.61634436
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59858089
68Rheumatoid arthritis_Homo sapiens_hsa053230.59343915
69Ribosome_Homo sapiens_hsa030100.55299919
70Non-homologous end-joining_Homo sapiens_hsa034500.55122411
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53040645
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52062390
73Phagosome_Homo sapiens_hsa041450.51876758
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51145268
75Endocytosis_Homo sapiens_hsa041440.49545513
76Inositol phosphate metabolism_Homo sapiens_hsa005620.49247681
77MicroRNAs in cancer_Homo sapiens_hsa052060.48699485
78Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48058306
79Base excision repair_Homo sapiens_hsa034100.47919491
80MAPK signaling pathway_Homo sapiens_hsa040100.44021882
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40191395
82Prostate cancer_Homo sapiens_hsa052150.40139901
83Spliceosome_Homo sapiens_hsa030400.40122023
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.39193437
85Regulation of autophagy_Homo sapiens_hsa041400.38628093
86Proteoglycans in cancer_Homo sapiens_hsa052050.38157749
87Insulin resistance_Homo sapiens_hsa049310.37836750
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37782969
89Other glycan degradation_Homo sapiens_hsa005110.37761173
90Notch signaling pathway_Homo sapiens_hsa043300.37319263
91Renal cell carcinoma_Homo sapiens_hsa052110.36789635
92DNA replication_Homo sapiens_hsa030300.33973667
93Pathways in cancer_Homo sapiens_hsa052000.33500836
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.33148028
95Adherens junction_Homo sapiens_hsa045200.32476236
96mTOR signaling pathway_Homo sapiens_hsa041500.31817195
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31792131
98HIF-1 signaling pathway_Homo sapiens_hsa040660.31487924
99Mismatch repair_Homo sapiens_hsa034300.31024669
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29300674
101RNA degradation_Homo sapiens_hsa030180.27142066
102Systemic lupus erythematosus_Homo sapiens_hsa053220.26976821
103Caffeine metabolism_Homo sapiens_hsa002320.26697289
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26256044
105Nitrogen metabolism_Homo sapiens_hsa009100.26106325
106Linoleic acid metabolism_Homo sapiens_hsa005910.25811880
107Circadian rhythm_Homo sapiens_hsa047100.24718886
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23919496
109Focal adhesion_Homo sapiens_hsa045100.23457756
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.22354542
111Rap1 signaling pathway_Homo sapiens_hsa040150.22215942
112Amoebiasis_Homo sapiens_hsa051460.21851202
113Cell cycle_Homo sapiens_hsa041100.21507770
114Choline metabolism in cancer_Homo sapiens_hsa052310.21491067
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.21145120
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.16715036
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16541068
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.15032527
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14374236
120Ras signaling pathway_Homo sapiens_hsa040140.11975249
121Lysosome_Homo sapiens_hsa041420.11839540
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11403878

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