STK24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.78237105
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.68758876
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.68758876
4positive regulation of gamma-delta T cell activation (GO:0046645)4.30719956
5antigen processing and presentation of endogenous antigen (GO:0019883)4.22559815
6hemidesmosome assembly (GO:0031581)3.91418302
7positive regulation of Cdc42 GTPase activity (GO:0043089)3.71250151
8regulation of water loss via skin (GO:0033561)3.70227320
9regulation of gamma-delta T cell differentiation (GO:0045586)3.67285536
10hypotonic response (GO:0006971)3.63322185
11regulation of early endosome to late endosome transport (GO:2000641)3.55989718
12establishment of skin barrier (GO:0061436)3.52055162
13positive thymic T cell selection (GO:0045059)3.49457225
14regulation of gamma-delta T cell activation (GO:0046643)3.36891045
15Arp2/3 complex-mediated actin nucleation (GO:0034314)3.31452667
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.30059123
17regulation of interleukin-12 biosynthetic process (GO:0045075)3.28860866
18protein localization to endosome (GO:0036010)3.26357709
19positive regulation of B cell differentiation (GO:0045579)3.21484078
20hepatocyte apoptotic process (GO:0097284)3.21267513
21negative thymic T cell selection (GO:0045060)3.19340040
22cell-substrate junction assembly (GO:0007044)3.15341181
23negative regulation of phagocytosis (GO:0050765)3.14779282
24embryonic process involved in female pregnancy (GO:0060136)3.12714609
25antigen processing and presentation via MHC class Ib (GO:0002475)3.10322821
26negative T cell selection (GO:0043383)3.09998229
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.08415197
28thymic T cell selection (GO:0045061)3.08135359
29gap junction assembly (GO:0016264)3.06060806
30bundle of His cell to Purkinje myocyte communication (GO:0086069)3.05207058
31NIK/NF-kappaB signaling (GO:0038061)3.00799894
32regulation of B cell differentiation (GO:0045577)2.99693394
33epithelial cell differentiation involved in prostate gland development (GO:0060742)2.98290698
34histone H3-K36 demethylation (GO:0070544)2.96404256
35regulation of B cell receptor signaling pathway (GO:0050855)2.92014482
36leukocyte aggregation (GO:0070486)2.91944860
373-UTR-mediated mRNA stabilization (GO:0070935)2.88661183
38ribosomal small subunit assembly (GO:0000028)2.88072248
39response to laminar fluid shear stress (GO:0034616)2.86938699
40regulation of cholesterol homeostasis (GO:2000188)2.85575572
41viral transcription (GO:0019083)2.82907602
42tolerance induction (GO:0002507)2.82689870
43negative regulation of cell killing (GO:0031342)2.80789402
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80789402
45epithelial cell-cell adhesion (GO:0090136)2.80160945
46natural killer cell differentiation (GO:0001779)2.78699829
47keratinocyte proliferation (GO:0043616)2.78226695
48positive regulation of histone deacetylation (GO:0031065)2.78122512
49nuclear pore complex assembly (GO:0051292)2.78087615
50DNA unwinding involved in DNA replication (GO:0006268)2.76178835
51protein localization to kinetochore (GO:0034501)2.75945448
52cell-substrate adherens junction assembly (GO:0007045)2.75024564
53focal adhesion assembly (GO:0048041)2.75024564
54definitive hemopoiesis (GO:0060216)2.73287191
55megakaryocyte development (GO:0035855)2.73270301
56mitotic nuclear envelope disassembly (GO:0007077)2.71532122
57adherens junction assembly (GO:0034333)2.70961865
58translational termination (GO:0006415)2.70307205
59pinocytosis (GO:0006907)2.70084598
60B cell receptor signaling pathway (GO:0050853)2.68920007
61activation of Rac GTPase activity (GO:0032863)2.68296364
62cellular response to virus (GO:0098586)2.67123310
63positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65860411
64planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65851716
65modulation by symbiont of host cellular process (GO:0044068)2.65034960
66T cell selection (GO:0045058)2.63991903
67positive regulation of lamellipodium assembly (GO:0010592)2.63636527
68regulation of NFAT protein import into nucleus (GO:0051532)2.63627575
69T cell apoptotic process (GO:0070231)2.63446867
70nuclear pore organization (GO:0006999)2.61725237
71immunoglobulin mediated immune response (GO:0016064)2.60342607
72cellular extravasation (GO:0045123)2.60328744
73skin morphogenesis (GO:0043589)2.59949464
74mitotic sister chromatid cohesion (GO:0007064)2.59228583
75interferon-gamma production (GO:0032609)2.58941409
76nuclear envelope disassembly (GO:0051081)2.57650829
77membrane disassembly (GO:0030397)2.57650829
78trophectodermal cell differentiation (GO:0001829)2.53544741
79protein localization to chromosome, centromeric region (GO:0071459)2.53354592
80keratinocyte differentiation (GO:0030216)2.53066591
81regulation of type I interferon-mediated signaling pathway (GO:0060338)2.51104483
82regulation of tight junction assembly (GO:2000810)2.50890212
83T cell migration (GO:0072678)2.49700196
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.49289394
85myeloid dendritic cell activation (GO:0001773)2.49125010
86stress fiber assembly (GO:0043149)2.48889746
87mRNA stabilization (GO:0048255)2.48215345
88RNA stabilization (GO:0043489)2.48215345
89modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46991000
90positive regulation by organism of defense response of other organism involved in symbiotic interact2.46991000
91modulation by symbiont of host immune response (GO:0052553)2.46991000
92positive regulation by symbiont of host defense response (GO:0052509)2.46991000
93modulation by symbiont of host defense response (GO:0052031)2.46991000
94modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46991000
95detection of other organism (GO:0098543)2.46691253
96positive T cell selection (GO:0043368)2.45389533
97JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.44822534
98regulation of transforming growth factor beta1 production (GO:0032908)2.44548480
99germ cell migration (GO:0008354)2.44247925
100response to interleukin-15 (GO:0070672)2.44101559
101chronic inflammatory response (GO:0002544)2.43981062
102positive regulation of protein deacetylation (GO:0090312)2.43519357
103negative regulation of erythrocyte differentiation (GO:0045647)2.42553661
104detection of bacterium (GO:0016045)2.42391253
105receptor catabolic process (GO:0032801)2.41682571
106regulation of response to interferon-gamma (GO:0060330)2.41614215
107actin nucleation (GO:0045010)2.41310104
108negative regulation of histone methylation (GO:0031061)2.40979186
109regulation of necroptotic process (GO:0060544)2.40584853
110regulation of RNA export from nucleus (GO:0046831)2.40519421
111keratinization (GO:0031424)2.39337038
112nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.37800780
113positive regulation of isotype switching (GO:0045830)2.37247055
114regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.37193288
115regulation of nucleobase-containing compound transport (GO:0032239)2.37114716
116leukocyte cell-cell adhesion (GO:0007159)2.36493623
117translational elongation (GO:0006414)2.35691669
118glucocorticoid receptor signaling pathway (GO:0042921)2.34736227
119positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.34485401
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.34385752
121mitotic chromosome condensation (GO:0007076)2.34053064
122negative regulation of interleukin-12 production (GO:0032695)2.33882364
123T cell costimulation (GO:0031295)2.33699344
124T cell homeostasis (GO:0043029)2.33195001
125lymphocyte apoptotic process (GO:0070227)2.33125603
126response to muramyl dipeptide (GO:0032495)2.32399852
127negative regulation of stress fiber assembly (GO:0051497)2.31748236
128regulation of erythrocyte differentiation (GO:0045646)2.31571916
129pore complex assembly (GO:0046931)2.30577636
130heterochromatin organization (GO:0070828)2.29854590
131endocytic recycling (GO:0032456)2.29697027
132positive regulation of lamellipodium organization (GO:1902745)2.29273159
133barbed-end actin filament capping (GO:0051016)2.29174329
134lymphocyte costimulation (GO:0031294)2.29124217
135B cell mediated immunity (GO:0019724)2.28966532
136multicellular organismal water homeostasis (GO:0050891)2.28052387
137regulation of integrin activation (GO:0033623)2.27954104
138cellular protein complex localization (GO:0034629)2.27400370
139regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.27169018
140nuclear envelope organization (GO:0006998)2.25511112
141folic acid-containing compound biosynthetic process (GO:0009396)2.24448360
142histone mRNA catabolic process (GO:0071044)2.23919615
143angiogenesis involved in wound healing (GO:0060055)2.23747652
144myeloid dendritic cell differentiation (GO:0043011)2.23704878
145regulation of protein heterodimerization activity (GO:0043497)2.23674631
146regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.23411005
147translational initiation (GO:0006413)2.22806584
148embryonic hemopoiesis (GO:0035162)2.22647056
149maternal placenta development (GO:0001893)2.22409777
150peptide catabolic process (GO:0043171)2.21961799
151signal complex assembly (GO:0007172)2.21325434
152surfactant homeostasis (GO:0043129)2.20366888
153negative regulation of toll-like receptor signaling pathway (GO:0034122)2.19292225
154negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.18642451
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.18387832
156negative regulation of protein localization to plasma membrane (GO:1903077)2.17379428
157regulation of vitamin metabolic process (GO:0030656)2.15769077
158apoptotic process involved in morphogenesis (GO:0060561)2.14243190
159regulation of glucose import in response to insulin stimulus (GO:2001273)2.12898463
160histone H3-K9 demethylation (GO:0033169)2.12695201
161regulation of podosome assembly (GO:0071801)2.12335039
162negative regulation of anoikis (GO:2000811)2.11858902
163epidermal cell differentiation (GO:0009913)2.11588276
164cellular response to epidermal growth factor stimulus (GO:0071364)2.11521243
165mammary gland epithelial cell proliferation (GO:0033598)2.11221129
166branching involved in mammary gland duct morphogenesis (GO:0060444)2.09497235
167negative regulation of homotypic cell-cell adhesion (GO:0034111)2.08110458
168negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.07373103
169negative regulation of keratinocyte proliferation (GO:0010839)2.07225586
170protein localization to microtubule (GO:0035372)2.06214748
171regulation of vitamin D biosynthetic process (GO:0060556)2.05706273
172regulation of keratinocyte differentiation (GO:0045616)2.05398123
173mesodermal cell differentiation (GO:0048333)2.04667311
174lipopolysaccharide-mediated signaling pathway (GO:0031663)2.04081402

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.46557839
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.03320244
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.44131526
4MYC_22102868_ChIP-Seq_BL_Human3.34315263
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19806339
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.94580255
7* FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72791991
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70626358
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.66061740
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.61478482
11VDR_21846776_ChIP-Seq_THP-1_Human2.49688605
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40937294
13* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.35210925
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.23239786
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.20589927
16MAF_26560356_Chip-Seq_TH1_Human2.15022078
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.13884278
18SCL_19346495_ChIP-Seq_HPC-7_Human2.13173217
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.12581094
20MYB_26560356_Chip-Seq_TH2_Human2.12500551
21* TCF7_22412390_ChIP-Seq_EML_Mouse2.08680649
22ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.06118559
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04924400
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03045973
25* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96318541
26* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.94378652
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.93357796
28* UTX_26944678_Chip-Seq_JUKART_Human1.92374499
29MYB_26560356_Chip-Seq_TH1_Human1.90837640
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.89591490
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86211654
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84103732
33* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81951873
34SPI1_23547873_ChIP-Seq_NB4_Human1.80364828
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77222382
36* CLOCK_20551151_ChIP-Seq_293T_Human1.76687242
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.74852559
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73229674
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.72975789
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.72865931
41VDR_24763502_ChIP-Seq_THP-1_Human1.72444619
42* IRF8_27001747_Chip-Seq_BMDM_Mouse1.70638911
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69261334
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67161630
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66734098
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.66531895
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.65573194
48KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65229041
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58840409
50SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.58226265
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.57378430
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57346596
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57346596
54* RUNX_20019798_ChIP-Seq_JUKART_Human1.57233380
55KDM2B_26808549_Chip-Seq_DND41_Human1.53551422
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.53436906
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.52856900
58CIITA_25753668_ChIP-Seq_RAJI_Human1.52118724
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.51689552
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.51201172
61P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48104067
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48036944
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.45695636
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45667002
65LXR_22292898_ChIP-Seq_THP-1_Human1.42648846
66KDM2B_26808549_Chip-Seq_K562_Human1.41917420
67* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41859217
68* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39444027
69CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.35976038
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.35340626
71MAF_26560356_Chip-Seq_TH2_Human1.34963171
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.33588613
73ZNF263_19887448_ChIP-Seq_K562_Human1.33064421
74* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32294830
75Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30591387
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29843031
77SPI1_23127762_ChIP-Seq_K562_Human1.29484564
78AR_21909140_ChIP-Seq_LNCAP_Human1.28940805
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28760267
80KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.28019774
81KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.28019774
82KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.28019774
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26934641
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26755625
85* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26629282
86* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26254373
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26183255
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25867889
89* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25009586
90TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23090299
91ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22802417
92GATA1_22025678_ChIP-Seq_K562_Human1.22485852
93GATA6_25053715_ChIP-Seq_YYC3_Human1.21072956
94NCOR1_26117541_ChIP-Seq_K562_Human1.19401218
95UBF1/2_26484160_Chip-Seq_HMECs_Human1.18616348
96GATA3_27048872_Chip-Seq_THYMUS_Human1.18526544
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18474097
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.17700203
99* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17249778
100BP1_19119308_ChIP-ChIP_Hs578T_Human1.17141467
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17025039
102TP63_17297297_ChIP-ChIP_HaCaT_Human1.14759911
103ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.14459056
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13766680
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13113960
106TFEB_21752829_ChIP-Seq_HELA_Human1.11498354
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11245700
108ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09469482
109KDM5A_27292631_Chip-Seq_BREAST_Human1.08413337
110VDR_23849224_ChIP-Seq_CD4+_Human1.07703349
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07113164
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06960986
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06684141
114RUNX1_27514584_Chip-Seq_MCF-7_Human1.06493642
115XRN2_22483619_ChIP-Seq_HELA_Human1.05777053
116ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04339325
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04189164
118MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04185106
119* PU_27001747_Chip-Seq_BMDM_Mouse1.03989245
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03970348
121NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02411371
122DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.01837409
123TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01042163
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01011844
125SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00650457
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00319018
127ATF3_27146783_Chip-Seq_COLON_Human0.98955183
128* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97714856
129GATA1_19941826_ChIP-Seq_K562_Human0.97706057
130EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97398305
131SOX2_20726797_ChIP-Seq_SW620_Human0.97229156
132* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95525663
133TP63_19390658_ChIP-ChIP_HaCaT_Human0.94085882
134HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93643609
135DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.93573406
136KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93529581
137FOXP3_21729870_ChIP-Seq_TREG_Human0.93110010
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.92401768
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88872390
140LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87523131
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87043211
142MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83689932
143FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.83609140
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83308267
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82810272
146CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82554552
147CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81345439
148CHD1_26751641_Chip-Seq_LNCaP_Human0.80973964
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80828901
150RACK7_27058665_Chip-Seq_MCF-7_Human0.80559606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier3.63272614
2MP0002396_abnormal_hematopoietic_system2.88375150
3MP0001835_abnormal_antigen_presentation2.69629037
4MP0003300_gastrointestinal_ulcer2.68493209
5MP0000685_abnormal_immune_system2.55979732
6MP0003303_peritoneal_inflammation2.48985552
7MP0010352_gastrointestinal_tract_polyps2.48193408
8MP0005501_abnormal_skin_physiology2.36593776
9MP0003763_abnormal_thymus_physiology2.34376617
10MP0004185_abnormal_adipocyte_glucose2.32073207
11MP0004808_abnormal_hematopoietic_stem2.31441034
12MP0001800_abnormal_humoral_immune2.29857596
13MP0003693_abnormal_embryo_hatching2.20733989
14MP0005671_abnormal_response_to2.19552451
15MP0005409_darkened_coat_color2.17006114
16MP0002398_abnormal_bone_marrow2.14935204
17MP0003436_decreased_susceptibility_to2.13015929
18MP0009278_abnormal_bone_marrow2.11802704
19MP0005387_immune_system_phenotype2.11354817
20MP0001790_abnormal_immune_system2.11354817
21MP0002166_altered_tumor_susceptibility2.08768767
22MP0002452_abnormal_antigen_presenting2.07199947
23MP0001545_abnormal_hematopoietic_system2.05880610
24MP0005397_hematopoietic_system_phenotyp2.05880610
25MP0009379_abnormal_foot_pigmentation2.02088011
26MP0002420_abnormal_adaptive_immunity1.97548706
27MP0001819_abnormal_immune_cell1.96388376
28MP0009333_abnormal_splenocyte_physiolog1.93046867
29MP0005000_abnormal_immune_tolerance1.92336492
30MP0005076_abnormal_cell_differentiation1.89214856
31MP0002723_abnormal_immune_serum1.88110863
32MP0009785_altered_susceptibility_to1.82190959
33MP0000490_abnormal_crypts_of1.80474904
34MP0002722_abnormal_immune_system1.79213689
35MP0005025_abnormal_response_to1.78690187
36MP0000716_abnormal_immune_system1.78402999
37MP0002405_respiratory_system_inflammati1.76913435
38MP0001873_stomach_inflammation1.76762789
39MP0005451_abnormal_body_composition1.76514917
40MP0000689_abnormal_spleen_morphology1.76297280
41MP0005464_abnormal_platelet_physiology1.76294907
42MP0010155_abnormal_intestine_physiology1.75494428
43MP0002877_abnormal_melanocyte_morpholog1.74774038
44MP0001849_ear_inflammation1.73582457
45MP0003111_abnormal_nucleus_morphology1.73140410
46MP0002006_tumorigenesis1.70085875
47MP0010307_abnormal_tumor_latency1.69640369
48MP0003077_abnormal_cell_cycle1.69248416
49MP0010094_abnormal_chromosome_stability1.66815408
50MP0004947_skin_inflammation1.65303513
51MP0000703_abnormal_thymus_morphology1.64135612
52MP0003941_abnormal_skin_development1.63130561
53MP0002419_abnormal_innate_immunity1.61509981
54MP0002429_abnormal_blood_cell1.61351440
55MP0004957_abnormal_blastocyst_morpholog1.59194098
56MP0006054_spinal_hemorrhage1.56410551
57MP0003705_abnormal_hypodermis_morpholog1.53886407
58MP0010678_abnormal_skin_adnexa1.45217334
59MP0008057_abnormal_DNA_replication1.43965154
60MP0003566_abnormal_cell_adhesion1.42831164
61MP0008004_abnormal_stomach_pH1.40630010
62MP0005275_abnormal_skin_tensile1.39359729
63MP0001853_heart_inflammation1.37604630
64MP0004510_myositis1.35843610
65MP0002148_abnormal_hypersensitivity_rea1.35820282
66MP0000465_gastrointestinal_hemorrhage1.34719597
67MP0005666_abnormal_adipose_tissue1.34647925
68MP0000858_altered_metastatic_potential1.34348663
69MP0002060_abnormal_skin_morphology1.33320527
70MP0002019_abnormal_tumor_incidence1.32923508
71MP0001845_abnormal_inflammatory_respons1.31083854
72MP0003866_abnormal_defecation1.26702187
73MP0003448_altered_tumor_morphology1.22829067
74MP0008260_abnormal_autophagy1.22159806
75MP0002998_abnormal_bone_remodeling1.21140666
76MP0000579_abnormal_nail_morphology1.21046960
77MP0005310_abnormal_salivary_gland1.18551520
78MP0003191_abnormal_cellular_cholesterol1.18362297
79MP0005257_abnormal_intraocular_pressure1.17145266
80MP0000350_abnormal_cell_proliferation1.17117875
81MP0000566_synostosis1.15363005
82MP0010234_abnormal_vibrissa_follicle1.15200917
83MP0005023_abnormal_wound_healing1.14821971
84MP0002089_abnormal_postnatal_growth/wei1.14321740
85MP0002098_abnormal_vibrissa_morphology1.13325480
86MP0008007_abnormal_cellular_replicative1.13091221
87MP0004381_abnormal_hair_follicle1.11533164
88MP0000377_abnormal_hair_follicle1.09917912
89MP0003183_abnormal_peptide_metabolism1.05791726
90MP0006082_CNS_inflammation1.04505729
91MP0001533_abnormal_skeleton_physiology1.04023354
92MP0001730_embryonic_growth_arrest1.03854076
93MP0005174_abnormal_tail_pigmentation1.03142069
94MP0000537_abnormal_urethra_morphology1.02684079
95MP0002138_abnormal_hepatobiliary_system1.00256926
96MP0009931_abnormal_skin_appearance0.97612465
97MP0009053_abnormal_anal_canal0.97034418
98MP0002086_abnormal_extraembryonic_tissu0.95948674
99MP0003724_increased_susceptibility_to0.95855859
100MP0010771_integument_phenotype0.95722407
101MP0003984_embryonic_growth_retardation0.92651331
102MP0001915_intracranial_hemorrhage0.92462821
103MP0000313_abnormal_cell_death0.91530789
104MP0002933_joint_inflammation0.91123505
105MP0002088_abnormal_embryonic_growth/wei0.91072417
106MP0003453_abnormal_keratinocyte_physiol0.90930384
107MP0000678_abnormal_parathyroid_gland0.89373589
108MP0003567_abnormal_fetal_cardiomyocyte0.87258366
109MP0001672_abnormal_embryogenesis/_devel0.86922870
110MP0005380_embryogenesis_phenotype0.86922870
111MP0003656_abnormal_erythrocyte_physiolo0.86082702
112MP0002009_preneoplasia0.86030918
113MP0009840_abnormal_foam_cell0.85777913
114MP0000762_abnormal_tongue_morphology0.85117671
115MP0005375_adipose_tissue_phenotype0.84680714
116MP0000343_altered_response_to0.84506461
117MP0000477_abnormal_intestine_morphology0.82908511
118MP0003828_pulmonary_edema0.81508275
119MP0000733_abnormal_muscle_development0.81176083
120MP0001851_eye_inflammation0.80744176
121MP0003091_abnormal_cell_migration0.80590296
122MP0001697_abnormal_embryo_size0.79351734
123MP0004264_abnormal_extraembryonic_tissu0.79053698
124MP0000428_abnormal_craniofacial_morphol0.77953900
125MP0002080_prenatal_lethality0.76807449
126MP0008469_abnormal_protein_level0.75737441
127MP0000627_abnormal_mammary_gland0.74706926
128MP0005621_abnormal_cell_physiology0.74223579
129MP0001348_abnormal_lacrimal_gland0.72590447
130MP0001216_abnormal_epidermal_layer0.70477973
131MP0008961_abnormal_basal_metabolism0.70101262
132MP0000383_abnormal_hair_follicle0.69538348
133MP0003123_paternal_imprinting0.67299065
134MP0005058_abnormal_lysosome_morphology0.67062601

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)3.93403070
2Eczematoid dermatitis (HP:0000976)3.56497026
3Recurrent viral infections (HP:0004429)3.46337359
4Abnormality of the fingertips (HP:0001211)3.35950865
5Myositis (HP:0100614)3.33412742
6Cellulitis (HP:0100658)3.32558595
7Recurrent fungal infections (HP:0002841)3.31597585
8Recurrent abscess formation (HP:0002722)3.29218709
9Thrombocytosis (HP:0001894)3.15802768
10Chronic otitis media (HP:0000389)3.13938098
11Abnormality of nail color (HP:0100643)3.00232638
12Selective tooth agenesis (HP:0001592)2.97643463
13Ankyloglossia (HP:0010296)2.97250195
14Recurrent bacterial skin infections (HP:0005406)2.96570513
15Flat acetabular roof (HP:0003180)2.93766852
16Thick nail (HP:0001805)2.93657993
17Pustule (HP:0200039)2.87751248
18Milia (HP:0001056)2.86374705
19Recurrent bronchitis (HP:0002837)2.79672383
20Fragile nails (HP:0001808)2.79134180
21T lymphocytopenia (HP:0005403)2.76907653
22Right ventricular cardiomyopathy (HP:0011663)2.74715178
23Increased density of long bones (HP:0006392)2.67011641
24Abnormality of T cells (HP:0002843)2.66156619
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.63640724
26Orchitis (HP:0100796)2.62756655
27Abnormality of T cell number (HP:0011839)2.61995901
28Nasal polyposis (HP:0100582)2.61367236
29Meningitis (HP:0001287)2.59736724
30Mediastinal lymphadenopathy (HP:0100721)2.58505870
31Spontaneous hematomas (HP:0007420)2.55436844
32Malnutrition (HP:0004395)2.55083923
33Gastrointestinal inflammation (HP:0004386)2.52516150
34Plantar hyperkeratosis (HP:0007556)2.51469834
35Inflammation of the large intestine (HP:0002037)2.51009077
36Papilloma (HP:0012740)2.50927441
37Verrucae (HP:0200043)2.50927441
38Petechiae (HP:0000967)2.49349112
39Abnormality of the salivary glands (HP:0010286)2.48147723
40Periodontitis (HP:0000704)2.45903529
41Prolonged bleeding time (HP:0003010)2.42824137
42Increased IgE level (HP:0003212)2.41986548
43Abnormality of T cell physiology (HP:0011840)2.41489482
44Arterial thrombosis (HP:0004420)2.40759116
45Panhypogammaglobulinemia (HP:0003139)2.39051729
46Chronic obstructive pulmonary disease (HP:0006510)2.38848182
47Obstructive lung disease (HP:0006536)2.38848182
48Abnormality of oral frenula (HP:0000190)2.37612617
49Agammaglobulinemia (HP:0004432)2.36623778
50Abnormality of the nasal mucosa (HP:0000433)2.35554604
51Optic neuritis (HP:0100653)2.35135655
52Retrobulbar optic neuritis (HP:0100654)2.35135655
53Onycholysis (HP:0001806)2.34637176
54Autoimmune thrombocytopenia (HP:0001973)2.33947573
55Premature loss of primary teeth (HP:0006323)2.33707975
56Acute myeloid leukemia (HP:0004808)2.32981760
57Hematochezia (HP:0002573)2.31453940
58Tetraparesis (HP:0002273)2.31190087
59Abnormal platelet function (HP:0011869)2.31188852
60Impaired platelet aggregation (HP:0003540)2.31188852
61Osteolytic defects of the phalanges of the hand (HP:0009771)2.23994777
62Osteolytic defects of the hand bones (HP:0009699)2.23994777
63Elevated erythrocyte sedimentation rate (HP:0003565)2.22440619
64Abnormality of the distal phalanx of the thumb (HP:0009617)2.22239246
65Lip pit (HP:0100267)2.22056827
66Chest pain (HP:0100749)2.20802572
67Basal cell carcinoma (HP:0002671)2.19097947
68Vasculitis (HP:0002633)2.18677627
69Ridged nail (HP:0001807)2.18201952
70Pulmonary infiltrates (HP:0002113)2.18083897
71Volvulus (HP:0002580)2.16912593
72IgA deficiency (HP:0002720)2.16823908
73Palmoplantar hyperkeratosis (HP:0000972)2.15954160
74B lymphocytopenia (HP:0010976)2.15456119
75Abnormality of B cell number (HP:0010975)2.15456119
76Lymphopenia (HP:0001888)2.14582528
77Interstitial pulmonary disease (HP:0006530)2.13319903
78Osteomyelitis (HP:0002754)2.12374662
79Colitis (HP:0002583)2.10390115
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.09871030
81Alopecia of scalp (HP:0002293)2.08224384
82Fatigue (HP:0012378)2.08081071
83Abnormal platelet volume (HP:0011876)2.07728767
84Atrophic scars (HP:0001075)2.06347584
85Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.06333295
86Aortic aneurysm (HP:0004942)2.05955569
87Entropion (HP:0000621)2.04008194
88Prominent nose (HP:0000448)2.03775105
89Curly hair (HP:0002212)2.03613822
90Palmar hyperkeratosis (HP:0010765)2.02224726
91Abnormality of macrophages (HP:0004311)2.01990333
92Recurrent skin infections (HP:0001581)2.01614177
93Protrusio acetabuli (HP:0003179)2.01059678
94Leukocytosis (HP:0001974)2.00832707
95Hyperacusis (HP:0010780)2.00628070
96Leiomyosarcoma (HP:0100243)1.99769463
97Uterine leiomyosarcoma (HP:0002891)1.99769463
98Epistaxis (HP:0000421)1.98567735
99Subacute progressive viral hepatitis (HP:0006572)1.97028513
100Hypoplasia of dental enamel (HP:0006297)1.96953974
101Viral hepatitis (HP:0006562)1.95334726
102Hypotrichosis (HP:0001006)1.95283715
103Abnormal blistering of the skin (HP:0008066)1.95086609
104Syringomyelia (HP:0003396)1.94600868
105Spinal cord lesions (HP:0100561)1.94600868
106Cerebral aneurysm (HP:0004944)1.94387079
107Lymphoma (HP:0002665)1.94293024
108Sparse scalp hair (HP:0002209)1.92944971
109Emphysema (HP:0002097)1.92685569
110Recurrent cutaneous fungal infections (HP:0011370)1.92524653
111Chronic mucocutaneous candidiasis (HP:0002728)1.92524653
112Rectal prolapse (HP:0002035)1.92030442
113Encephalitis (HP:0002383)1.91223286
114Thyroiditis (HP:0100646)1.90638961
115IgG deficiency (HP:0004315)1.89513828
116Amaurosis fugax (HP:0100576)1.89288770
117Poikiloderma (HP:0001029)1.88519117
118Skin ulcer (HP:0200042)1.88331151
119Segmental peripheral demyelination/remyelination (HP:0003481)1.88072494
120Blepharitis (HP:0000498)1.87989436
121Thin bony cortex (HP:0002753)1.87728149
122Vertebral arch anomaly (HP:0008438)1.87500204
123Aplasia involving bones of the upper limbs (HP:0009823)1.86531916
124Aplasia of the phalanges of the hand (HP:0009802)1.86531916
125Aplasia involving bones of the extremities (HP:0009825)1.86531916
126Malignant gastrointestinal tract tumors (HP:0006749)1.86368329
127Gastrointestinal carcinoma (HP:0002672)1.86368329
128Eosinophilia (HP:0001880)1.85936094
129Deviation of the thumb (HP:0009603)1.84132746
130Cutaneous melanoma (HP:0012056)1.83079055
131Vertebral compression fractures (HP:0002953)1.82735104
132Fragile skin (HP:0001030)1.82222585
133High pitched voice (HP:0001620)1.82149606
134Abnormality of cells of the erythroid lineage (HP:0012130)1.81985674
135Short middle phalanx of the 5th finger (HP:0004220)1.81831902
136Gastrointestinal stroma tumor (HP:0100723)1.80792227
137Long eyelashes (HP:0000527)1.80718644
138Abnormality of eosinophils (HP:0001879)1.80253846
139Combined immunodeficiency (HP:0005387)1.80207654
140Transitional cell carcinoma of the bladder (HP:0006740)1.80048746
141Hemoptysis (HP:0002105)1.78992956
142Bicuspid aortic valve (HP:0001647)1.78975272
143Nail dystrophy (HP:0008404)1.78845598
144Reticulocytopenia (HP:0001896)1.77464699
145Persistence of primary teeth (HP:0006335)1.77218773
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.72479017
147Broad face (HP:0000283)1.69563202
148Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69499930
149Increased mean platelet volume (HP:0011877)1.69487277
150Polygenic inheritance (HP:0010982)1.69471179
151Abnormality of the dental root (HP:0006486)1.69057394
152Taurodontia (HP:0000679)1.69057394
153Abnormality of permanent molar morphology (HP:0011071)1.69057394
154Natal tooth (HP:0000695)1.68913213
155Bladder carcinoma (HP:0002862)1.68700847
156Bladder neoplasm (HP:0009725)1.68700847
157Gingivitis (HP:0000230)1.64713651
158Nasolacrimal duct obstruction (HP:0000579)1.64510747
159Renal cell carcinoma (HP:0005584)1.63978231
160Achilles tendon contracture (HP:0001771)1.63573790
161Erythema (HP:0010783)1.62711884
162Abnormality of the gastric mucosa (HP:0004295)1.62102887
163Abnormality of the distal phalanges of the toes (HP:0010182)1.61869329
164Pili torti (HP:0003777)1.61709213
165Bone pain (HP:0002653)1.60283384
166Distal lower limb amyotrophy (HP:0008944)1.60158000
167Long palpebral fissure (HP:0000637)1.60001630
168Papillary thyroid carcinoma (HP:0002895)1.58113817
169Abnormality of molar morphology (HP:0011070)1.56797105
170Abnormality of molar (HP:0011077)1.56797105
171Hyperparathyroidism (HP:0000843)1.56565430
172Disproportionate tall stature (HP:0001519)1.56243558
173Abnormality of the Achilles tendon (HP:0005109)1.53809544
174Abnormality of the thoracic spine (HP:0100711)1.52090629
175Dry hair (HP:0011359)1.51994035
176Purpura (HP:0000979)1.51302801
177Advanced eruption of teeth (HP:0006288)1.51071373
178Arterial tortuosity (HP:0005116)1.50751337
179Absent eyelashes (HP:0000561)1.47330745
180Hemorrhage of the eye (HP:0011885)1.46901240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.87277829
2PRPF4B3.63964433
3EEF2K3.25304524
4PKN23.17463183
5TRIB33.06669416
6MAP3K102.64879419
7STK102.64222872
8SMG12.48077634
9MST1R2.40850022
10CDK122.31187108
11EPHA22.19883547
12MAP3K92.14699848
13LRRK22.09092648
14TXK1.94195726
15JAK31.90292778
16ICK1.89096918
17ZAP701.86798448
18ERN11.70394795
19NEK21.69671685
20BTK1.68718235
21GRK61.64308069
22LATS21.63558418
23SIK11.62483363
24TYK21.62388717
25PDGFRA1.60434806
26KSR21.59232960
27KIT1.58441791
28RIPK41.56975935
29CDK41.51192428
30TBK11.50652268
31MET1.50518297
32FLT31.50234305
33RPS6KA41.49187260
34PIM11.48208676
35TAOK31.43114411
36CDC71.39867607
37PTK61.39849386
38CDK61.36764044
39* STK31.35182515
40ARAF1.34894778
41MAP2K31.34876006
42BLK1.30848373
43RPS6KB21.27039380
44ITK1.22884824
45TAOK21.21668602
46CSF1R1.20778664
47TEC1.20732295
48PIM21.17289451
49MAP3K81.15479190
50MAP3K11.14260624
51MAP3K21.14194391
52JAK11.13385574
53TAOK11.13203736
54NME21.11757391
55SYK1.11564408
56RIPK11.10366382
57STK41.10343834
58FGFR31.09220154
59ALK1.08331996
60IKBKB1.06731830
61IKBKE1.04518157
62MOS1.03865454
63BRD41.03191271
64LMTK21.02380659
65HCK1.01279391
66BRAF1.01137283
67SCYL20.98501652
68MAP3K140.97146555
69PTK20.96364612
70EPHB10.94177321
71WEE10.94086014
72CDC42BPA0.93447657
73CHUK0.92320799
74MAP3K60.91793026
75TTN0.91603749
76CSK0.91332706
77LCK0.90051608
78FGR0.88566835
79EPHB20.88479319
80TYRO30.88338641
81DMPK0.85846546
82TGFBR20.85402819
83IRAK40.84503914
84MAPK70.84281843
85PAK40.83373430
86PDGFRB0.82999101
87NEK90.82779700
88FGFR40.81766440
89NLK0.78192538
90KSR10.77778728
91MARK20.77088236
92SGK30.76560535
93CDK90.75291089
94TGFBR10.75105755
95MATK0.74817299
96JAK20.73015107
97MAP3K130.72072967
98TTK0.71794625
99CDK70.71755082
100IRAK20.71734952
101ACVR1B0.66838569
102DDR20.64930412
103PDPK10.63813228
104MTOR0.63332603
105LATS10.62816619
106MELK0.60176746
107YES10.59819025
108LYN0.59340931
109ATR0.59328055
110RET0.57659434
111BMX0.57517335
112AURKB0.57040958
113TRPM70.54784415
114EIF2AK10.54609069
115BRSK20.54384743
116NTRK10.53948758
117CLK10.52837192
118RAF10.52808420
119MAP3K30.52583439
120KDR0.52224435
121MAP3K110.52107019
122IRAK10.51394793
123MAPKAPK30.51046871
124TSSK60.50791542
125MARK30.50745510
126WNK10.49894625
127MAPK110.48970911
128CHEK10.48844223
129CAMK1G0.48229694
130MAPKAPK20.48065813
131CAMK1D0.46290673
132RPS6KC10.46016433
133RPS6KL10.46016433
134TESK20.45501844
135MAPK120.45049957
136MAP3K70.44740086
137HIPK20.44600310
138PDK10.44005672
139FGFR10.42008003
140PRKG20.41444562
141RPS6KA20.41124867
142IRAK30.40852649
143FES0.38770105
144MAP3K50.38369988
145ABL10.38190732
146MST40.37929786

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.63630176
2Primary immunodeficiency_Homo sapiens_hsa053402.36076477
3Leishmaniasis_Homo sapiens_hsa051402.11532178
4B cell receptor signaling pathway_Homo sapiens_hsa046622.06951863
5Antigen processing and presentation_Homo sapiens_hsa046121.98289516
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.93375286
7DNA replication_Homo sapiens_hsa030301.89709205
8Osteoclast differentiation_Homo sapiens_hsa043801.81706900
9Measles_Homo sapiens_hsa051621.77634518
10Intestinal immune network for IgA production_Homo sapiens_hsa046721.69869984
11Chronic myeloid leukemia_Homo sapiens_hsa052201.69618323
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68483481
13Bladder cancer_Homo sapiens_hsa052191.66345047
14Acute myeloid leukemia_Homo sapiens_hsa052211.63982529
15Toxoplasmosis_Homo sapiens_hsa051451.62637924
16Cell cycle_Homo sapiens_hsa041101.62074902
17Herpes simplex infection_Homo sapiens_hsa051681.59277805
18Hematopoietic cell lineage_Homo sapiens_hsa046401.55615062
19T cell receptor signaling pathway_Homo sapiens_hsa046601.53383392
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53034394
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51671147
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50615662
23Small cell lung cancer_Homo sapiens_hsa052221.43901775
24Jak-STAT signaling pathway_Homo sapiens_hsa046301.39334279
25Hepatitis B_Homo sapiens_hsa051611.38605410
26Apoptosis_Homo sapiens_hsa042101.37950824
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.34938978
28Shigellosis_Homo sapiens_hsa051311.33473987
29Pancreatic cancer_Homo sapiens_hsa052121.33309213
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31716482
31Mismatch repair_Homo sapiens_hsa034301.31515141
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28367325
33Ribosome_Homo sapiens_hsa030101.27572040
34p53 signaling pathway_Homo sapiens_hsa041151.26796976
35Viral carcinogenesis_Homo sapiens_hsa052031.25453249
36Viral myocarditis_Homo sapiens_hsa054161.24757422
37Base excision repair_Homo sapiens_hsa034101.24729982
38Legionellosis_Homo sapiens_hsa051341.24046590
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23741169
40Influenza A_Homo sapiens_hsa051641.22627445
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.22462457
42TNF signaling pathway_Homo sapiens_hsa046681.19309261
43RNA transport_Homo sapiens_hsa030131.16619919
44Colorectal cancer_Homo sapiens_hsa052101.15036197
45Epstein-Barr virus infection_Homo sapiens_hsa051691.14632979
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14371291
47Platelet activation_Homo sapiens_hsa046111.13157361
48HTLV-I infection_Homo sapiens_hsa051661.13115801
49Non-small cell lung cancer_Homo sapiens_hsa052231.12854326
50ErbB signaling pathway_Homo sapiens_hsa040121.12187628
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09245548
52Dorso-ventral axis formation_Homo sapiens_hsa043201.06366171
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06059295
54Spliceosome_Homo sapiens_hsa030401.04647734
55Tuberculosis_Homo sapiens_hsa051521.02603929
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.01652258
57MicroRNAs in cancer_Homo sapiens_hsa052060.98756027
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.96601734
59Chemokine signaling pathway_Homo sapiens_hsa040620.96064978
60mTOR signaling pathway_Homo sapiens_hsa041500.94592336
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94036290
62Thyroid cancer_Homo sapiens_hsa052160.93365623
63Allograft rejection_Homo sapiens_hsa053300.93229777
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.92434756
65VEGF signaling pathway_Homo sapiens_hsa043700.92357024
66Choline metabolism in cancer_Homo sapiens_hsa052310.92330214
67Inositol phosphate metabolism_Homo sapiens_hsa005620.90942272
68Homologous recombination_Homo sapiens_hsa034400.90578530
69Glioma_Homo sapiens_hsa052140.90564115
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.90197303
71One carbon pool by folate_Homo sapiens_hsa006700.89764594
72Insulin signaling pathway_Homo sapiens_hsa049100.89381030
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89269479
74Prolactin signaling pathway_Homo sapiens_hsa049170.88253544
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.88092376
76GnRH signaling pathway_Homo sapiens_hsa049120.88059904
77Malaria_Homo sapiens_hsa051440.85926336
78Non-homologous end-joining_Homo sapiens_hsa034500.85589872
79Pertussis_Homo sapiens_hsa051330.84694453
80Endometrial cancer_Homo sapiens_hsa052130.80367368
81ECM-receptor interaction_Homo sapiens_hsa045120.79333715
82Proteoglycans in cancer_Homo sapiens_hsa052050.78926274
83Prion diseases_Homo sapiens_hsa050200.78400577
84Endocytosis_Homo sapiens_hsa041440.77217398
85Hepatitis C_Homo sapiens_hsa051600.74987106
86FoxO signaling pathway_Homo sapiens_hsa040680.74630927
87RNA degradation_Homo sapiens_hsa030180.74421014
88Sphingolipid metabolism_Homo sapiens_hsa006000.74141197
89Salmonella infection_Homo sapiens_hsa051320.73051065
90Adherens junction_Homo sapiens_hsa045200.72492037
91HIF-1 signaling pathway_Homo sapiens_hsa040660.71663516
92mRNA surveillance pathway_Homo sapiens_hsa030150.70024995
93Galactose metabolism_Homo sapiens_hsa000520.68017619
94Renin-angiotensin system_Homo sapiens_hsa046140.67970427
95Prostate cancer_Homo sapiens_hsa052150.67294200
96Amoebiasis_Homo sapiens_hsa051460.66825241
97Notch signaling pathway_Homo sapiens_hsa043300.66630186
98Pentose phosphate pathway_Homo sapiens_hsa000300.66480522
99Asthma_Homo sapiens_hsa053100.66426103
100Rap1 signaling pathway_Homo sapiens_hsa040150.64060543
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63815351
102Focal adhesion_Homo sapiens_hsa045100.62749794
103Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62277744
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.62104696
105Tight junction_Homo sapiens_hsa045300.61805853
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61085274
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61079357
108Nucleotide excision repair_Homo sapiens_hsa034200.60731461
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60656272
110Other glycan degradation_Homo sapiens_hsa005110.60475014
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58916690
112Graft-versus-host disease_Homo sapiens_hsa053320.58481689
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57561286
114Staphylococcus aureus infection_Homo sapiens_hsa051500.57378405
115Pathways in cancer_Homo sapiens_hsa052000.57124298
116Insulin resistance_Homo sapiens_hsa049310.56980043
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.56767492
118Fructose and mannose metabolism_Homo sapiens_hsa000510.55765227
119Glycosaminoglycan degradation_Homo sapiens_hsa005310.53370429
120Gap junction_Homo sapiens_hsa045400.52814711
121Lysine degradation_Homo sapiens_hsa003100.52416804
122Fanconi anemia pathway_Homo sapiens_hsa034600.51794967
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51681357
124Renal cell carcinoma_Homo sapiens_hsa052110.51311227
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50813544
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50061089
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48876906
128Hippo signaling pathway_Homo sapiens_hsa043900.48414132
129African trypanosomiasis_Homo sapiens_hsa051430.48373199

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »