STK24P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.91366429
2B cell mediated immunity (GO:0019724)5.03581648
3cytidine deamination (GO:0009972)4.62312216
4cytidine metabolic process (GO:0046087)4.62312216
5cytidine catabolic process (GO:0006216)4.62312216
6proteasome assembly (GO:0043248)4.38371024
7immunoglobulin mediated immune response (GO:0016064)4.35088428
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.01602503
9interferon-gamma production (GO:0032609)3.98074936
10pyrimidine ribonucleoside catabolic process (GO:0046133)3.84042135
11signal peptide processing (GO:0006465)3.61389008
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.52937654
13rRNA methylation (GO:0031167)3.47548642
14rRNA modification (GO:0000154)3.46635908
15interferon-gamma-mediated signaling pathway (GO:0060333)3.38256530
16T cell costimulation (GO:0031295)3.32932236
17lymphocyte costimulation (GO:0031294)3.28383050
18regulation of mitochondrial translation (GO:0070129)3.18607226
19negative regulation of cell killing (GO:0031342)3.18510353
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18510353
21negative regulation of B cell activation (GO:0050869)3.17146644
22regulation of isotype switching to IgG isotypes (GO:0048302)3.12903334
23positive regulation of T-helper 1 type immune response (GO:0002827)3.12789766
24regulation of B cell receptor signaling pathway (GO:0050855)3.10264240
25positive regulation of monocyte chemotaxis (GO:0090026)3.08032766
26positive regulation of T cell mediated cytotoxicity (GO:0001916)3.05809028
27rRNA catabolic process (GO:0016075)3.03661944
28N-acetylneuraminate metabolic process (GO:0006054)3.01485952
29regulation of T cell tolerance induction (GO:0002664)3.00046762
30regulation of alpha-beta T cell proliferation (GO:0046640)2.98280293
31positive regulation of defense response to virus by host (GO:0002230)2.96706487
32regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94544800
33exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93588554
34somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.92858266
35isotype switching (GO:0045190)2.92858266
36somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.92858266
37chaperone mediated protein folding requiring cofactor (GO:0051085)2.90826256
38regulation of T cell mediated cytotoxicity (GO:0001914)2.88952481
39nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84712517
40chaperone-mediated protein transport (GO:0072321)2.83943975
41positive thymic T cell selection (GO:0045059)2.82562533
42cellular response to interferon-gamma (GO:0071346)2.80835803
43positive T cell selection (GO:0043368)2.79899226
44RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.79718380
45positive regulation of protein homooligomerization (GO:0032464)2.78014103
46maturation of 5.8S rRNA (GO:0000460)2.78001299
47antigen processing and presentation via MHC class Ib (GO:0002475)2.77414906
48positive regulation of T cell mediated immunity (GO:0002711)2.75052997
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.73865961
50positive regulation of heat generation (GO:0031652)2.73239756
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.72421530
52antigen receptor-mediated signaling pathway (GO:0050851)2.71011166
53negative T cell selection (GO:0043383)2.70099504
54positive regulation of interleukin-8 secretion (GO:2000484)2.68306190
55regulation of tolerance induction (GO:0002643)2.67910494
56T cell receptor signaling pathway (GO:0050852)2.66889488
57antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.65708998
58negative thymic T cell selection (GO:0045060)2.65484164
59ribosome assembly (GO:0042255)2.63154155
60response to interferon-gamma (GO:0034341)2.61079006
61positive regulation of interferon-gamma production (GO:0032729)2.59831513
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.59736042
63positive regulation of tolerance induction (GO:0002645)2.57995371
64antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.56988045
65activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.55395446
66protein K6-linked ubiquitination (GO:0085020)2.54709615
67protein neddylation (GO:0045116)2.51918197
68positive regulation of mast cell activation (GO:0033005)2.51341389
69negative regulation by host of viral transcription (GO:0043922)2.50904051
70intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.48164900
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.47753084
72negative regulation of viral entry into host cell (GO:0046597)2.47152305
73regulation of defense response to virus by host (GO:0050691)2.46012066
74regulation of heat generation (GO:0031650)2.45551250
75antigen processing and presentation of endogenous antigen (GO:0019883)2.45221151
76histone H2A ubiquitination (GO:0033522)2.43066561
77cellular response to interleukin-15 (GO:0071350)2.42412451
78positive regulation of adaptive immune response based on somatic recombination of immune receptors b2.42062037
79histamine secretion (GO:0001821)2.40078166
80positive regulation of natural killer cell differentiation (GO:0032825)2.39636021
81positive regulation of granulocyte differentiation (GO:0030854)2.39388157
82N-acetylglucosamine metabolic process (GO:0006044)2.38645738
83regulation of meiosis I (GO:0060631)2.38645607
84positive regulation of protein homodimerization activity (GO:0090073)2.38266041
85negative regulation of B cell proliferation (GO:0030889)2.37282459
86positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.37171547
87positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.37063082
88regulation of T-helper 1 type immune response (GO:0002825)2.37045063
89neutrophil activation involved in immune response (GO:0002283)2.36468010
90mannosylation (GO:0097502)2.35341985
91regulation of fever generation (GO:0031620)2.35263194
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.35198718
93mitochondrial calcium ion transport (GO:0006851)2.35187608
94regulation of T cell receptor signaling pathway (GO:0050856)2.34879781
95regulation of cellular amino acid metabolic process (GO:0006521)2.34878837
96DNA catabolic process, exonucleolytic (GO:0000738)2.34551841
97negative regulation of type 2 immune response (GO:0002829)2.34116533
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.33612914
99positive regulation of adaptive immune response (GO:0002821)2.32069166
100pyrimidine nucleoside catabolic process (GO:0046135)2.31783496

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.44270119
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.69732187
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.66692717
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.62125357
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.34682929
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29184877
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03995327
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.75100672
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.69149544
10ELK1_19687146_ChIP-ChIP_HELA_Human2.63192667
11VDR_23849224_ChIP-Seq_CD4+_Human2.57502789
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.53685960
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46313384
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45127950
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33177634
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.32019339
17MYB_26560356_Chip-Seq_TH2_Human2.12178781
18HOXB4_20404135_ChIP-ChIP_EML_Mouse2.09394402
19CIITA_25753668_ChIP-Seq_RAJI_Human2.02329786
20FOXP3_21729870_ChIP-Seq_TREG_Human1.99597400
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.98899731
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.97043402
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95222894
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94163229
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94161529
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.90742665
27FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.88782905
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87485793
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85255415
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.83504354
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83283028
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82175262
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81619430
34SPI1_23547873_ChIP-Seq_NB4_Human1.79354250
35GATA3_26560356_Chip-Seq_TH2_Human1.66614754
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.63257622
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61702960
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.56990044
39GATA3_27048872_Chip-Seq_THYMUS_Human1.51617097
40IRF8_27001747_Chip-Seq_BMDM_Mouse1.49070722
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48006561
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46728658
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36136831
44AR_20517297_ChIP-Seq_VCAP_Human1.35109657
45IRF1_19129219_ChIP-ChIP_H3396_Human1.33866834
46MYC_18940864_ChIP-ChIP_HL60_Human1.32734244
47SRF_21415370_ChIP-Seq_HL-1_Mouse1.32457597
48E2F7_22180533_ChIP-Seq_HELA_Human1.30232405
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30021579
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27637356
51ZNF274_21170338_ChIP-Seq_K562_Hela1.27346492
52DCP1A_22483619_ChIP-Seq_HELA_Human1.26045513
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22730740
54HTT_18923047_ChIP-ChIP_STHdh_Human1.22224838
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21417107
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18431547
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17915885
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17433741
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.16786552
60TFEB_21752829_ChIP-Seq_HELA_Human1.15586961
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15233405
62MYB_26560356_Chip-Seq_TH1_Human1.14173495
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13906107
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.13811509
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.13508112
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13386922
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12521832
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.09601558
69MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08903162
70VDR_22108803_ChIP-Seq_LS180_Human1.08157227
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08073089
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07543923
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07313635
74PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06317073
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04857482
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04598276
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04006637
78TTF2_22483619_ChIP-Seq_HELA_Human1.03854036
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03272387
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.01202449
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98681601
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.97811261
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97028944
84MYC_18358816_ChIP-ChIP_MESCs_Mouse0.96962441
85GATA3_26560356_Chip-Seq_TH1_Human0.96172568
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95669556
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.95017447
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94097119
89TP53_22573176_ChIP-Seq_HFKS_Human0.93868392
90SALL4_22934838_ChIP-ChIP_CD34+_Human0.93425546
91NANOG_19829295_ChIP-Seq_ESCs_Human0.93381695
92SOX2_19829295_ChIP-Seq_ESCs_Human0.93381695
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93159201
94FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92829376
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91876275
96GATA3_21878914_ChIP-Seq_MCF-7_Human0.91572664
97EWS_26573619_Chip-Seq_HEK293_Human0.91386416
98RUNX_20019798_ChIP-Seq_JUKART_Human0.91370189
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90959925
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.90352744

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.23086703
2MP0005671_abnormal_response_to3.99618094
3MP0000685_abnormal_immune_system3.58177452
4MP0003763_abnormal_thymus_physiology2.91788463
5MP0003724_increased_susceptibility_to2.80243389
6MP0001790_abnormal_immune_system2.50501382
7MP0005387_immune_system_phenotype2.50501382
8MP0005075_abnormal_melanosome_morpholog2.49937391
9MP0009785_altered_susceptibility_to2.49579702
10MP0002166_altered_tumor_susceptibility2.49067648
11MP0005000_abnormal_immune_tolerance2.47093755
12MP0009333_abnormal_splenocyte_physiolog2.41022145
13MP0002138_abnormal_hepatobiliary_system2.37759681
14MP0003786_premature_aging2.37561216
15MP0006072_abnormal_retinal_apoptosis2.33090080
16MP0001800_abnormal_humoral_immune2.25348332
17MP0002006_tumorigenesis2.20125057
18MP0002148_abnormal_hypersensitivity_rea2.06887725
19MP0006082_CNS_inflammation2.06566530
20MP0002723_abnormal_immune_serum2.03637618
21MP0001819_abnormal_immune_cell2.01192756
22MP0005084_abnormal_gallbladder_morpholo2.00856623
23MP0006054_spinal_hemorrhage2.00414228
24MP0002452_abnormal_antigen_presenting1.96759788
25MP0002420_abnormal_adaptive_immunity1.93344667
26MP0005464_abnormal_platelet_physiology1.86632999
27MP0002398_abnormal_bone_marrow1.77250108
28MP0002405_respiratory_system_inflammati1.75876833
29MP0001873_stomach_inflammation1.71498933
30MP0008007_abnormal_cellular_replicative1.70604320
31MP0003195_calcinosis1.69684335
32MP0004147_increased_porphyrin_level1.68348151
33MP0004947_skin_inflammation1.67321781
34MP0001188_hyperpigmentation1.63529682
35MP0009764_decreased_sensitivity_to1.60528842
36MP0002254_reproductive_system_inflammat1.58931749
37MP0000716_abnormal_immune_system1.56948592
38MP0000689_abnormal_spleen_morphology1.56884858
39MP0005025_abnormal_response_to1.52964690
40MP0010155_abnormal_intestine_physiology1.51359130
41MP0000703_abnormal_thymus_morphology1.49452335
42MP0002722_abnormal_immune_system1.47589171
43MP0003172_abnormal_lysosome_physiology1.45575387
44MP0001845_abnormal_inflammatory_respons1.44587155
45MP0002163_abnormal_gland_morphology1.42853633
46MP0008058_abnormal_DNA_repair1.42246183
47MP0002837_dystrophic_cardiac_calcinosis1.37061807
48MP0002429_abnormal_blood_cell1.36407842
49MP0002419_abnormal_innate_immunity1.36251317
50MP0004957_abnormal_blastocyst_morpholog1.32701140
51MP0003111_abnormal_nucleus_morphology1.29800728
52MP0010094_abnormal_chromosome_stability1.29323896
53MP0008004_abnormal_stomach_pH1.29266077
54MP0000465_gastrointestinal_hemorrhage1.25046677
55MP0002102_abnormal_ear_morphology1.24206310
56MP0003866_abnormal_defecation1.24031331
57MP0005623_abnormal_meninges_morphology1.23166284
58MP0005379_endocrine/exocrine_gland_phen1.22400366
59MP0002396_abnormal_hematopoietic_system1.21075354
60MP0003436_decreased_susceptibility_to1.20561021
61MP0005645_abnormal_hypothalamus_physiol1.13427517
62MP0010234_abnormal_vibrissa_follicle1.11430392
63MP0005310_abnormal_salivary_gland1.08660910
64MP0008875_abnormal_xenobiotic_pharmacok1.08385779
65MP0009697_abnormal_copulation1.06944192
66MP0008995_early_reproductive_senescence1.03127650
67MP0001542_abnormal_bone_strength1.01511427
68MP0006036_abnormal_mitochondrial_physio1.00676245
69MP0001853_heart_inflammation0.99753658
70MP0001529_abnormal_vocalization0.99121311
71MP0008057_abnormal_DNA_replication0.98760678
72MP0003693_abnormal_embryo_hatching0.98598229
73MP0003806_abnormal_nucleotide_metabolis0.96601451
74MP0002693_abnormal_pancreas_physiology0.94141939
75MP0001533_abnormal_skeleton_physiology0.93751427
76MP0001765_abnormal_ion_homeostasis0.92314236
77MP0002019_abnormal_tumor_incidence0.92019937
78MP0004808_abnormal_hematopoietic_stem0.91727098
79MP0004084_abnormal_cardiac_muscle0.91073461
80MP0000372_irregular_coat_pigmentation0.90488711
81MP0001191_abnormal_skin_condition0.88508668
82MP0005253_abnormal_eye_physiology0.86366885
83MP0004381_abnormal_hair_follicle0.82750302
84MP0008469_abnormal_protein_level0.82208539
85MP0002277_abnormal_respiratory_mucosa0.80052612
86MP0000613_abnormal_salivary_gland0.77511311
87MP0000490_abnormal_crypts_of0.74747648
88MP0005332_abnormal_amino_acid0.74038807
89MP0005410_abnormal_fertilization0.72467657
90MP0008872_abnormal_physiological_respon0.70870310
91MP0010352_gastrointestinal_tract_polyps0.70801632
92MP0006292_abnormal_olfactory_placode0.70691892
93MP0009763_increased_sensitivity_to0.70309976
94MP0008873_increased_physiological_sensi0.66725327
95MP0005636_abnormal_mineral_homeostasis0.65837254
96MP0000313_abnormal_cell_death0.64925520
97MP0001919_abnormal_reproductive_system0.63623722
98MP0003448_altered_tumor_morphology0.61621307
99MP0001346_abnormal_lacrimal_gland0.60338998
100MP0005167_abnormal_blood-brain_barrier0.59839171

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)5.33971611
2Increased IgM level (HP:0003496)4.23941251
3Elevated erythrocyte sedimentation rate (HP:0003565)4.09723636
4Hemoptysis (HP:0002105)3.66961296
5Increased hepatocellular lipid droplets (HP:0006565)3.52668543
6Eosinophilia (HP:0001880)3.50022419
7Abnormality of the prostate (HP:0008775)3.47712910
8Hypoproteinemia (HP:0003075)3.33740266
9Obstructive lung disease (HP:0006536)3.31700567
10Chronic obstructive pulmonary disease (HP:0006510)3.31700567
11Abnormality of eosinophils (HP:0001879)3.17384312
12Meningitis (HP:0001287)3.11520318
13Lipid accumulation in hepatocytes (HP:0006561)3.07356216
14Vasculitis (HP:0002633)3.03493403
15Abnormality of the pleura (HP:0002103)2.96799383
16Methylmalonic acidemia (HP:0002912)2.94762488
17Abnormality of T cell number (HP:0011839)2.92102665
18Exertional dyspnea (HP:0002875)2.87061813
19Encephalitis (HP:0002383)2.83477233
20Cerebral palsy (HP:0100021)2.81307756
21Granulocytopenia (HP:0001913)2.77576502
22Type II lissencephaly (HP:0007260)2.75894299
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.66272106
24Increased intramyocellular lipid droplets (HP:0012240)2.64565053
25Congenital, generalized hypertrichosis (HP:0004540)2.63632979
26Skin rash (HP:0000988)2.62248987
27Optic neuritis (HP:0100653)2.61128279
28Retrobulbar optic neuritis (HP:0100654)2.61128279
29IgG deficiency (HP:0004315)2.58152607
30Myositis (HP:0100614)2.57435515
31Pulmonary infiltrates (HP:0002113)2.55217393
32Glomerulopathy (HP:0100820)2.54057212
33Fatigue (HP:0012378)2.53000726
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.51026463
35Chest pain (HP:0100749)2.47258041
36Autoimmune hemolytic anemia (HP:0001890)2.43080848
37Constricted visual fields (HP:0001133)2.42295664
38Leukocytosis (HP:0001974)2.40295135
39Decreased activity of mitochondrial respiratory chain (HP:0008972)2.39640982
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.39640982
41Cerebellar dysplasia (HP:0007033)2.39343664
42Renal cortical cysts (HP:0000803)2.36797324
43Carpal bone hypoplasia (HP:0001498)2.36244460
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.35735926
45Absent/shortened dynein arms (HP:0200106)2.35735926
46Alveolar cell carcinoma (HP:0006519)2.35441973
47Renal Fanconi syndrome (HP:0001994)2.35030393
48Amyotrophic lateral sclerosis (HP:0007354)2.32164037
49Increased CSF lactate (HP:0002490)2.31698034
50Orchitis (HP:0100796)2.23840447
51Severe combined immunodeficiency (HP:0004430)2.22555970
52Lymphoma (HP:0002665)2.21596073
53Aplastic anemia (HP:0001915)2.19767547
54Gastrointestinal infarctions (HP:0005244)2.19504835
55Adactyly (HP:0009776)2.18616634
56Abnormality of T cells (HP:0002843)2.17384055
57T lymphocytopenia (HP:0005403)2.16429836
58Neoplasm of the tracheobronchial system (HP:0100552)2.14596074
59Increased serum lactate (HP:0002151)2.13628818
60Fibular aplasia (HP:0002990)2.13518266
61Anorexia (HP:0002039)2.11694456
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10668608
63Hypergammaglobulinemia (HP:0010702)2.10122988
64Keratoconjunctivitis (HP:0001096)2.08713808
65Abnormality of male internal genitalia (HP:0000022)2.08435005
66Mitochondrial inheritance (HP:0001427)2.07782084
67Abnormality of the pericardium (HP:0001697)2.07349232
68Recurrent fungal infections (HP:0002841)2.06471459
69Gangrene (HP:0100758)2.06183161
70Petechiae (HP:0000967)2.05502192
71Increased muscle lipid content (HP:0009058)2.04493520
72Microretrognathia (HP:0000308)2.03951636
73Microvesicular hepatic steatosis (HP:0001414)2.01527190
74Methylmalonic aciduria (HP:0012120)1.98722837
75Hyperalaninemia (HP:0003348)1.97766000
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97766000
77Abnormality of alanine metabolism (HP:0010916)1.97766000
78Hypoalbuminemia (HP:0003073)1.97164472
79Abnormal albumin level (HP:0012116)1.97164472
80Autoimmune thrombocytopenia (HP:0001973)1.97006037
81Hepatocellular necrosis (HP:0001404)1.96122313
82Chronic otitis media (HP:0000389)1.95898806
83Lactic acidosis (HP:0003128)1.95342619
84Cerebral hemorrhage (HP:0001342)1.95260726
85Pulmonary fibrosis (HP:0002206)1.94933604
86Abnormal rod and cone electroretinograms (HP:0008323)1.94537113
87Combined immunodeficiency (HP:0005387)1.94351301
88Abnormality of vitamin B metabolism (HP:0004340)1.93959223
89Bile duct proliferation (HP:0001408)1.93719263
90Abnormal biliary tract physiology (HP:0012439)1.93719263
91Panhypogammaglobulinemia (HP:0003139)1.92265398
92Ureteral obstruction (HP:0006000)1.91838236
93Aplasia/hypoplasia of the uterus (HP:0008684)1.89410314
94Pancytopenia (HP:0001876)1.89264636
95Pancreatic cysts (HP:0001737)1.86678856
96Tongue fasciculations (HP:0001308)1.86265942
97Pustule (HP:0200039)1.85359069
98Ureteral stenosis (HP:0000071)1.84568349
99Anhidrosis (HP:0000970)1.84306935
100Abnormality of the vitamin B12 metabolism (HP:0004341)1.84020320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK245.02852501
2TXK4.26289344
3STK163.81084426
4EIF2AK33.44212157
5NUAK13.18898580
6SRPK13.07635362
7MAP3K142.75645281
8MST42.62611645
9ZAK2.40641722
10EIF2AK12.26023282
11TLK12.23900122
12SCYL22.05169254
13KDR1.98188717
14BMPR21.97915096
15MAP3K121.94030949
16IKBKB1.90959840
17MAP4K11.69231849
18ITK1.57534563
19STK31.56942277
20TRIM281.52187576
21MAP3K131.46015488
22CDK191.45699981
23BCR1.42652016
24WNK41.36117983
25MAPKAPK31.32709788
26VRK21.31390672
27AKT31.25032655
28BUB11.24444495
29EIF2AK21.24310690
30MAP2K61.23618998
31SIK21.23154526
32TEC1.13679489
33BCKDK1.11232989
34ACVR1B1.08067601
35BMPR1B1.06642153
36WNK31.06382712
37PRKG21.05902969
38MATK1.05757395
39PLK41.05233571
40IKBKE1.02449129
41ERBB31.01922148
42VRK10.99041470
43CSF1R0.98890599
44TBK10.95449369
45ADRBK20.94915200
46MYLK0.92043961
47KIT0.87141445
48GRK60.86387218
49ILK0.82416603
50CSNK1G30.82388846
51PLK30.81478253
52BRD40.76746968
53PRKCQ0.75063272
54JAK30.74744522
55PAK40.73270043
56FRK0.70787441
57PASK0.70184600
58BTK0.69274356
59NLK0.67794626
60SIK30.66668385
61CHUK0.66666594
62LCK0.64422228
63DAPK10.63679963
64ALK0.62905661
65CSNK1G10.62263899
66NEK20.62059356
67SYK0.61997828
68CSNK1A1L0.61935908
69TAOK30.60855827
70RPS6KA40.57490492
71GRK70.55229607
72RPS6KA50.51935366
73MKNK20.48949602
74CSK0.45633924
75HCK0.41783694
76CSNK1G20.40476186
77MAPK130.40049478
78LYN0.39536732
79CHEK20.38883933
80PLK10.38531733
81TSSK60.38301642
82EGFR0.38055897
83ABL10.35683108
84AURKB0.35157307
85MKNK10.34572360
86CSNK2A10.34386841
87CDK30.33922369
88BRAF0.33570730
89IGF1R0.33193907
90IRAK10.32908813
91STK38L0.32613931
92TESK20.32141982
93CDC70.31311963
94MAP2K20.30862044
95STK100.26334426
96PAK10.26203933
97PLK20.26051565
98GRK10.25798511
99FLT30.24864850
100OXSR10.23437548

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053324.99590349
2Allograft rejection_Homo sapiens_hsa053304.79623441
3Autoimmune thyroid disease_Homo sapiens_hsa053204.50705380
4Asthma_Homo sapiens_hsa053104.24052781
5Type I diabetes mellitus_Homo sapiens_hsa049404.05920393
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.30236304
7Antigen processing and presentation_Homo sapiens_hsa046123.04015913
8Protein export_Homo sapiens_hsa030602.59623789
9Proteasome_Homo sapiens_hsa030502.48662260
10Viral myocarditis_Homo sapiens_hsa054162.43645005
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.30727640
12Rheumatoid arthritis_Homo sapiens_hsa053232.13192348
13Primary immunodeficiency_Homo sapiens_hsa053402.13172146
14Sulfur metabolism_Homo sapiens_hsa009201.95717929
15Leishmaniasis_Homo sapiens_hsa051401.89560742
16Staphylococcus aureus infection_Homo sapiens_hsa051501.83120523
17Systemic lupus erythematosus_Homo sapiens_hsa053221.80213867
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65499223
19Basal transcription factors_Homo sapiens_hsa030221.64898140
20Herpes simplex infection_Homo sapiens_hsa051681.47229950
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35485829
22Non-homologous end-joining_Homo sapiens_hsa034501.28450921
23Hematopoietic cell lineage_Homo sapiens_hsa046401.26753238
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25212205
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12986280
26Legionellosis_Homo sapiens_hsa051341.12039659
27Propanoate metabolism_Homo sapiens_hsa006401.09199183
28Nitrogen metabolism_Homo sapiens_hsa009101.07588010
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.07477057
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.07445022
31Toxoplasmosis_Homo sapiens_hsa051450.97853658
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97423743
33NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96714395
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95913445
35Shigellosis_Homo sapiens_hsa051310.94516430
36Oxidative phosphorylation_Homo sapiens_hsa001900.87481624
37Tuberculosis_Homo sapiens_hsa051520.86438130
38Epstein-Barr virus infection_Homo sapiens_hsa051690.85184945
39RNA transport_Homo sapiens_hsa030130.83314896
40Measles_Homo sapiens_hsa051620.82283826
41Selenocompound metabolism_Homo sapiens_hsa004500.81149782
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80245816
43RNA degradation_Homo sapiens_hsa030180.78793190
44African trypanosomiasis_Homo sapiens_hsa051430.77113782
45T cell receptor signaling pathway_Homo sapiens_hsa046600.76306955
46Influenza A_Homo sapiens_hsa051640.76104246
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74886102
48Mismatch repair_Homo sapiens_hsa034300.69933983
49Parkinsons disease_Homo sapiens_hsa050120.69380662
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68550005
51Phagosome_Homo sapiens_hsa041450.67656996
52RNA polymerase_Homo sapiens_hsa030200.67309193
53p53 signaling pathway_Homo sapiens_hsa041150.67205365
54Viral carcinogenesis_Homo sapiens_hsa052030.67133344
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62563262
56Spliceosome_Homo sapiens_hsa030400.61692553
57DNA replication_Homo sapiens_hsa030300.57714245
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57446654
59Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57269032
60Regulation of autophagy_Homo sapiens_hsa041400.54102993
61Collecting duct acid secretion_Homo sapiens_hsa049660.52042685
62Homologous recombination_Homo sapiens_hsa034400.51098008
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50356409
64Pyrimidine metabolism_Homo sapiens_hsa002400.47337100
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44802893
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44465665
67Alcoholism_Homo sapiens_hsa050340.42774022
68Salmonella infection_Homo sapiens_hsa051320.41352212
69Fatty acid elongation_Homo sapiens_hsa000620.39619518
70TNF signaling pathway_Homo sapiens_hsa046680.38281607
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37512932
72HTLV-I infection_Homo sapiens_hsa051660.36801998
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36679614
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36677411
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.36002977
76Malaria_Homo sapiens_hsa051440.35837705
77One carbon pool by folate_Homo sapiens_hsa006700.34704847
78Platelet activation_Homo sapiens_hsa046110.34236249
79Nucleotide excision repair_Homo sapiens_hsa034200.33132000
80Huntingtons disease_Homo sapiens_hsa050160.31192725
81Apoptosis_Homo sapiens_hsa042100.30748516
82Oocyte meiosis_Homo sapiens_hsa041140.29293573
83Alzheimers disease_Homo sapiens_hsa050100.27976029
84Osteoclast differentiation_Homo sapiens_hsa043800.26043373
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25679968
86Purine metabolism_Homo sapiens_hsa002300.24360708
87Chemokine signaling pathway_Homo sapiens_hsa040620.23870987
88Phototransduction_Homo sapiens_hsa047440.22841737
89Peroxisome_Homo sapiens_hsa041460.21347241
90B cell receptor signaling pathway_Homo sapiens_hsa046620.20464665
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19673233
92mRNA surveillance pathway_Homo sapiens_hsa030150.18738646
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.18301639
94Olfactory transduction_Homo sapiens_hsa047400.17964958
95Fanconi anemia pathway_Homo sapiens_hsa034600.17754666
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17712694
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17613772
98Butanoate metabolism_Homo sapiens_hsa006500.17084996
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.15794810
100Steroid biosynthesis_Homo sapiens_hsa001000.14401259

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