STK25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.87481821
2synaptic vesicle maturation (GO:0016188)5.87326363
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.24896740
4synaptic vesicle exocytosis (GO:0016079)5.20568122
5locomotory exploration behavior (GO:0035641)5.13773149
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.09751598
7glutamate secretion (GO:0014047)4.80246609
8regulation of synaptic vesicle exocytosis (GO:2000300)4.77164461
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72582240
10vocalization behavior (GO:0071625)4.60294171
11sodium ion export (GO:0071436)4.43697617
12layer formation in cerebral cortex (GO:0021819)4.43212737
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34145874
14regulation of synaptic vesicle transport (GO:1902803)4.22419415
15cellular potassium ion homeostasis (GO:0030007)4.16790564
16protein localization to synapse (GO:0035418)4.09041170
17regulation of glutamate receptor signaling pathway (GO:1900449)4.08313697
18regulation of synapse structural plasticity (GO:0051823)4.07685640
19exploration behavior (GO:0035640)4.07620656
20cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.05594002
21muscle filament sliding (GO:0030049)3.98325880
22actin-myosin filament sliding (GO:0033275)3.98325880
23neurotransmitter secretion (GO:0007269)3.95339684
24cell communication by electrical coupling (GO:0010644)3.90617027
25positive regulation of synapse maturation (GO:0090129)3.90099297
26adherens junction assembly (GO:0034333)3.88993235
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.81381739
28cell-substrate adherens junction assembly (GO:0007045)3.78733145
29focal adhesion assembly (GO:0048041)3.78733145
30regulation of neuronal synaptic plasticity (GO:0048168)3.73454147
31activation of protein kinase A activity (GO:0034199)3.72684786
32protein retention in ER lumen (GO:0006621)3.67208653
33regulation of ARF protein signal transduction (GO:0032012)3.62161513
34proline biosynthetic process (GO:0006561)3.60918891
35negative regulation of cell size (GO:0045792)3.54704457
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.53224495
37semaphorin-plexin signaling pathway (GO:0071526)3.49103351
38regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.45693497
39sarcoplasmic reticulum calcium ion transport (GO:0070296)3.40779875
40basement membrane organization (GO:0071711)3.37382596
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.35619124
42neurotransmitter-gated ion channel clustering (GO:0072578)3.35261060
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.35135246
44COPI coating of Golgi vesicle (GO:0048205)3.30717864
45Golgi transport vesicle coating (GO:0048200)3.30717864
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.30664527
47synaptic transmission, glutamatergic (GO:0035249)3.29541925
48proline transport (GO:0015824)3.29108569
49actin-mediated cell contraction (GO:0070252)3.27142741
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25198964
51membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.22294219
52innervation (GO:0060384)3.21596087
53cell-substrate junction assembly (GO:0007044)3.20800893
54cerebellar Purkinje cell layer development (GO:0021680)3.18004477
55potassium ion homeostasis (GO:0055075)3.15566581
56NADH metabolic process (GO:0006734)3.15430628
57neuron cell-cell adhesion (GO:0007158)3.15327303
58regulation of mammary gland epithelial cell proliferation (GO:0033599)3.13996182
59cellular sodium ion homeostasis (GO:0006883)3.13281977
60skeletal muscle contraction (GO:0003009)3.13142262
61neuronal action potential propagation (GO:0019227)3.12792710
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11302025
63dendritic spine morphogenesis (GO:0060997)3.09082181
64positive regulation of membrane potential (GO:0045838)3.07915119
65neuromuscular process controlling balance (GO:0050885)3.06660038
66neurotransmitter transport (GO:0006836)3.05617262
67glutamate receptor signaling pathway (GO:0007215)3.05481476
68cell communication involved in cardiac conduction (GO:0086065)3.05283398
69negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.05262322
70dendrite morphogenesis (GO:0048813)3.04173235
71response to pheromone (GO:0019236)3.03945030
72neuron-neuron synaptic transmission (GO:0007270)3.02382918
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02102088
74long-term memory (GO:0007616)3.00457432
75positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00153447
76creatine metabolic process (GO:0006600)2.99769179
77membrane depolarization during action potential (GO:0086010)2.98970372
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97016433
79G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96572038
80regulation of neurotransmitter secretion (GO:0046928)2.95886207
81regulation of synaptic plasticity (GO:0048167)2.92243398
82convergent extension (GO:0060026)2.91541201
83membrane repolarization (GO:0086009)2.91233217
84positive regulation of potassium ion transmembrane transport (GO:1901381)2.90717433
85vesicle transport along microtubule (GO:0047496)2.90651258
86peptidyl-arginine omega-N-methylation (GO:0035247)2.90559232
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.89802030
88regulation of dendritic spine morphogenesis (GO:0061001)2.89379301
89positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88027209
90synaptic vesicle endocytosis (GO:0048488)2.88000097
91regulation of postsynaptic membrane potential (GO:0060078)2.85675906
92regulation of NFAT protein import into nucleus (GO:0051532)2.84041046
93cell migration in hindbrain (GO:0021535)2.83783850
94cochlea morphogenesis (GO:0090103)2.83620706
95cardiac myofibril assembly (GO:0055003)2.79901957
96positive regulation of myotube differentiation (GO:0010831)2.79779588
97regulation of early endosome to late endosome transport (GO:2000641)2.79680648
98membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.79509584
99apoptotic process involved in morphogenesis (GO:0060561)2.79461681
100postsynaptic membrane organization (GO:0001941)2.79122344
101regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.78114659
102neuromuscular process controlling posture (GO:0050884)2.77977069
103regulation of synapse maturation (GO:0090128)2.77955242
104cerebellar Purkinje cell differentiation (GO:0021702)2.77482499
105potassium ion import (GO:0010107)2.77391923
106response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.77294321
107mannose metabolic process (GO:0006013)2.77132486
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.76674305
109regulation of neurotransmitter levels (GO:0001505)2.76668127
110membrane hyperpolarization (GO:0060081)2.76663659
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76569466
112mitochondrion transport along microtubule (GO:0047497)2.76569466
113prepulse inhibition (GO:0060134)2.76416782
114actin filament-based movement (GO:0030048)2.76301322
115regulation of vesicle fusion (GO:0031338)2.75340512
116negative regulation of microtubule polymerization (GO:0031115)2.73442985
117skeletal muscle fiber development (GO:0048741)2.73244196
118dopamine receptor signaling pathway (GO:0007212)2.73118105
119positive regulation of neurotransmitter secretion (GO:0001956)2.72326871
120maternal placenta development (GO:0001893)2.72218714
121proline metabolic process (GO:0006560)2.71903931
122negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.71825621
123negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71065417
124cell-cell junction maintenance (GO:0045217)2.70590876
125long-term synaptic potentiation (GO:0060291)2.70346128
126mating behavior (GO:0007617)2.70168451
127regulation of synaptic transmission, glutamatergic (GO:0051966)2.69327418
128myofibril assembly (GO:0030239)2.69086973
129positive regulation of neurotransmitter transport (GO:0051590)2.68886516
130regulation of neurotransmitter transport (GO:0051588)2.68043936
131protein targeting to plasma membrane (GO:0072661)2.67041643
132establishment of mitochondrion localization (GO:0051654)2.64991560
133establishment of nucleus localization (GO:0040023)2.63306368
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.63088560
135neuron recognition (GO:0008038)2.62927036
136striated muscle contraction (GO:0006941)2.61877609
137muscle cell fate commitment (GO:0042693)2.61874101
138gluconeogenesis (GO:0006094)2.61152803
139regulation of calcium ion-dependent exocytosis (GO:0017158)2.59616515
140G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59387365
141axon cargo transport (GO:0008088)2.58337463
142axonal fasciculation (GO:0007413)2.57665907
143cAMP biosynthetic process (GO:0006171)2.57561421
144gamma-aminobutyric acid transport (GO:0015812)2.57270930
145membrane depolarization (GO:0051899)2.57129553
146dendritic spine organization (GO:0097061)2.55839433
147regulation of clathrin-mediated endocytosis (GO:2000369)2.55796180
148sarcomere organization (GO:0045214)2.55613382
149protein localization to endosome (GO:0036010)2.55458197
150plasma membrane repair (GO:0001778)2.55331024
151epithelial cell-cell adhesion (GO:0090136)2.54234198
152respiratory system process (GO:0003016)2.53971126
153vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.52758254
154paraxial mesoderm development (GO:0048339)2.52385831
155cardiac muscle contraction (GO:0060048)2.47127722
156barbed-end actin filament capping (GO:0051016)2.45604872
157insulin-like growth factor receptor signaling pathway (GO:0048009)2.43242137
158Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.43089955
1594-hydroxyproline metabolic process (GO:0019471)2.42881645
160regulation of glucose import in response to insulin stimulus (GO:2001273)2.42316743
161response to muscle activity (GO:0014850)2.41874349
162negative regulation of fatty acid transport (GO:2000192)2.41749652
163regulation of cholesterol biosynthetic process (GO:0045540)2.40359014
164hexose biosynthetic process (GO:0019319)2.40345600
165regulation of cholesterol homeostasis (GO:2000188)2.40162643
166negative regulation of erythrocyte differentiation (GO:0045647)2.40099355
167stress fiber assembly (GO:0043149)2.39843904
168positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38090525
169establishment of apical/basal cell polarity (GO:0035089)2.38031239
170intracellular estrogen receptor signaling pathway (GO:0030520)2.37783503
171regulation of skeletal muscle contraction (GO:0014819)2.37746477
172histone arginine methylation (GO:0034969)2.36698395
173activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.32544560
174actomyosin structure organization (GO:0031032)2.32429110
175peptidyl-arginine N-methylation (GO:0035246)2.30151328
176peptidyl-arginine methylation (GO:0018216)2.30151328
177adherens junction organization (GO:0034332)2.29946601
1782-oxoglutarate metabolic process (GO:0006103)2.29788057
179activation of Rac GTPase activity (GO:0032863)2.29734627
180myoblast fusion (GO:0007520)2.28815530
181regulation of establishment of planar polarity (GO:0090175)2.27379364
182actin filament depolymerization (GO:0030042)2.27244226
183positive regulation of receptor recycling (GO:0001921)2.26688686
184monosaccharide biosynthetic process (GO:0046364)2.26161065
185cell volume homeostasis (GO:0006884)2.25291629
186negative regulation of catenin import into nucleus (GO:0035414)2.24817620
187neural tube development (GO:0021915)2.21556349
188endothelial cell chemotaxis (GO:0035767)2.21195873
189protein heterotrimerization (GO:0070208)2.20822002
190positive regulation of nuclease activity (GO:0032075)2.20760167
191syncytium formation by plasma membrane fusion (GO:0000768)2.20581552
192vascular endothelial growth factor signaling pathway (GO:0038084)2.20444819
193glycogen catabolic process (GO:0005980)2.18602485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.01545311
2RARG_19884340_ChIP-ChIP_MEFs_Mouse2.96389093
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80198948
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.65200068
5* RARB_27405468_Chip-Seq_BRAIN_Mouse2.64000876
6DROSHA_22980978_ChIP-Seq_HELA_Human2.62617823
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.61871669
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56245717
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.53633347
10REST_21632747_ChIP-Seq_MESCs_Mouse2.43779149
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.42914903
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41261609
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38809598
14* ELK3_25401928_ChIP-Seq_HUVEC_Human2.38091698
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37823115
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.35993803
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.35993803
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.33947996
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.25908886
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24949143
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21079534
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.17016697
23RACK7_27058665_Chip-Seq_MCF-7_Human2.15747932
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14350983
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12203300
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11515218
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.09678585
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06214722
29KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02086111
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97026117
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94775824
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.92003483
33VDR_21846776_ChIP-Seq_THP-1_Human1.91365248
34GBX2_23144817_ChIP-Seq_PC3_Human1.90057836
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.89806961
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87708450
37MYC_22102868_ChIP-Seq_BL_Human1.86514762
38TET1_21451524_ChIP-Seq_MESCs_Mouse1.81819962
39CLOCK_20551151_ChIP-Seq_293T_Human1.80071336
40NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76195912
41P68_20966046_ChIP-Seq_HELA_Human1.71293625
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.68907343
43KDM2B_26808549_Chip-Seq_K562_Human1.68182787
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.67420877
45TCF7_22412390_ChIP-Seq_EML_Mouse1.66887527
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.63401104
47* ERG_21242973_ChIP-ChIP_JURKAT_Human1.62983287
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.59317916
49RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.57882228
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57719590
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57157770
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56790977
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52516611
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.51209552
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.50740692
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49630528
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46432663
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45728410
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45544984
60* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44692634
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.43942312
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43011867
63ZNF274_21170338_ChIP-Seq_K562_Hela1.42790920
64ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42382518
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42281944
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.41493306
67* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38862997
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.38520432
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37161286
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37005565
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36347884
72* TP53_22127205_ChIP-Seq_IMR90_Human1.32497763
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31439436
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30600166
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29830303
76WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29517390
77* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29325433
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27341780
79* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25988809
80SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.25569292
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24963136
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23771842
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23583727
84TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22644426
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22208975
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21384713
87NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21090651
88STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20801402
89LXR_22292898_ChIP-Seq_THP-1_Human1.20259390
90CTCF_27219007_Chip-Seq_Bcells_Human1.20021475
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.18226300
92AR_19668381_ChIP-Seq_PC3_Human1.17855412
93* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.17676721
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17233355
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16568821
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16036076
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.15752715
98ELF1_20517297_ChIP-Seq_JURKAT_Human1.14426181
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.12382654
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11618605
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11267143
102ZNF263_19887448_ChIP-Seq_K562_Human1.10913329
103SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10715789
104KDM2B_26808549_Chip-Seq_DND41_Human1.10682015
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10474923
106* TET1_21490601_ChIP-Seq_MESCs_Mouse1.10359115
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.10210419
108SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08688753
109* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.07506804
110SMAD4_21799915_ChIP-Seq_A2780_Human1.07343727
111STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06894838
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05667909
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05586705
114TBX20_22328084_ChIP-Seq_HEART_Mouse1.05085726
115TBX20_22080862_ChIP-Seq_HEART_Mouse1.05085726
116* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.04408654
117THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04393085
118RARA_24833708_ChIP-Seq_LIVER_Mouse1.04188571
119GATA1_22025678_ChIP-Seq_K562_Human1.03153801
120ATF3_27146783_Chip-Seq_COLON_Human1.02908201
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.02865460
122AR_21572438_ChIP-Seq_LNCaP_Human1.02545922
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02402165
124TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02095291
125ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01829209
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.01173637
127RING1B_27294783_Chip-Seq_NPCs_Mouse1.00884225
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.99891701
129* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99844455
130* SMC4_20622854_ChIP-Seq_HELA_Human0.99828862
131KDM2B_26808549_Chip-Seq_JURKAT_Human0.99024517
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97786430
133CREB1_26743006_Chip-Seq_LNCaP_Human0.97765947
134TP63_22573176_ChIP-Seq_HFKS_Human0.97567540
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97510237
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97474679
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96958808
138MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96781959
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95486176
140* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94908388
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.92925265
142KLF4_19829295_ChIP-Seq_ESCs_Human0.92625762
143EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91763850
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91389469
145RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89820682
146SMAD4_21741376_ChIP-Seq_HESCs_Human0.89703863
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87877432
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87299598
149ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86627634
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86480641
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86224984
152ELK4_26923725_Chip-Seq_MESODERM_Mouse0.84931924
153PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84507509
154AR_25329375_ChIP-Seq_VCAP_Human0.84326225
155P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82620204
156EP300_21415370_ChIP-Seq_HL-1_Mouse0.81690304
157ARNT_22903824_ChIP-Seq_MCF-7_Human0.81524423
158AHR_22903824_ChIP-Seq_MCF-7_Human0.81019011
159STAT3_23295773_ChIP-Seq_U87_Human0.79567995
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79520058
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.79515089
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79474811
163SMAD4_21741376_ChIP-Seq_ESCs_Human0.79060943
164CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77297299
165TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.76845375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.43028652
2MP0003635_abnormal_synaptic_transmissio3.79924839
3MP0004270_analgesia3.71729075
4MP0003880_abnormal_central_pattern3.37223995
5MP0002063_abnormal_learning/memory/cond2.94303340
6MP0008438_abnormal_cutaneous_collagen2.92954933
7MP0000749_muscle_degeneration2.76974594
8MP0009745_abnormal_behavioral_response2.76117957
9MP0002909_abnormal_adrenal_gland2.67532407
10MP0002822_catalepsy2.52947234
11MP0009780_abnormal_chondrocyte_physiolo2.50598213
12MP0002064_seizures2.49026637
13MP0010030_abnormal_orbit_morphology2.44195203
14MP0005451_abnormal_body_composition2.37163370
15MP0004272_abnormal_basement_membrane2.31037928
16MP0001849_ear_inflammation2.30770981
17MP0009046_muscle_twitch2.27957908
18MP0000759_abnormal_skeletal_muscle2.27348515
19MP0002734_abnormal_mechanical_nocicepti2.25002190
20MP0001968_abnormal_touch/_nociception2.24423560
21MP0002572_abnormal_emotion/affect_behav2.22959989
22MP0004087_abnormal_muscle_fiber2.19562769
23MP0000733_abnormal_muscle_development2.06926740
24MP0000751_myopathy2.01193791
25MP0005423_abnormal_somatic_nervous1.98355382
26MP0004858_abnormal_nervous_system1.97894596
27MP0002249_abnormal_larynx_morphology1.95458005
28MP0002272_abnormal_nervous_system1.91408081
29MP0003566_abnormal_cell_adhesion1.86148967
30MP0008569_lethality_at_weaning1.81188724
31MP0002733_abnormal_thermal_nociception1.79098282
32MP0003329_amyloid_beta_deposits1.78229994
33MP0010234_abnormal_vibrissa_follicle1.78018645
34MP0001486_abnormal_startle_reflex1.77134441
35MP0002106_abnormal_muscle_physiology1.76729032
36MP0004811_abnormal_neuron_physiology1.73894502
37MP0000750_abnormal_muscle_regeneration1.72989580
38MP0005058_abnormal_lysosome_morphology1.72173533
39MP0001501_abnormal_sleep_pattern1.71923126
40MP0003787_abnormal_imprinting1.70546646
41MP0002184_abnormal_innervation1.69421735
42MP0000537_abnormal_urethra_morphology1.66500330
43MP0000013_abnormal_adipose_tissue1.63956506
44MP0001440_abnormal_grooming_behavior1.63715859
45MP0003283_abnormal_digestive_organ1.63702117
46MP0005369_muscle_phenotype1.63418711
47MP0003879_abnormal_hair_cell1.62987338
48MP0005409_darkened_coat_color1.62204729
49MP0003122_maternal_imprinting1.60524852
50MP0001970_abnormal_pain_threshold1.59637136
51MP0008961_abnormal_basal_metabolism1.59589618
52MP0003279_aneurysm1.57030426
53MP0002067_abnormal_sensory_capabilities1.55773515
54MP0002269_muscular_atrophy1.55352287
55MP0004233_abnormal_muscle_weight1.53831265
56MP0002735_abnormal_chemical_nociception1.53787792
57MP0002736_abnormal_nociception_after1.53515241
58MP0002557_abnormal_social/conspecific_i1.53168580
59MP0010368_abnormal_lymphatic_system1.52657531
60MP0009384_cardiac_valve_regurgitation1.51550941
61MP0000955_abnormal_spinal_cord1.51158135
62MP0005257_abnormal_intraocular_pressure1.50926545
63MP0004185_abnormal_adipocyte_glucose1.50091574
64MP0008260_abnormal_autophagy1.48931087
65MP0002108_abnormal_muscle_morphology1.47274729
66MP0006138_congestive_heart_failure1.46631018
67MP0010630_abnormal_cardiac_muscle1.43294687
68MP0000678_abnormal_parathyroid_gland1.43028932
69MP0005330_cardiomyopathy1.40962563
70MP0000566_synostosis1.36195964
71MP0000778_abnormal_nervous_system1.35271446
72MP0005375_adipose_tissue_phenotype1.35078064
73MP0010386_abnormal_urinary_bladder1.34267026
74MP0001502_abnormal_circadian_rhythm1.32680865
75MP0005076_abnormal_cell_differentiation1.32614638
76MP0000767_abnormal_smooth_muscle1.30891030
77MP0009672_abnormal_birth_weight1.29868854
78MP0004924_abnormal_behavior1.27314655
79MP0005386_behavior/neurological_phenoty1.27314655
80MP0003646_muscle_fatigue1.27093116
81MP0002882_abnormal_neuron_morphology1.26226072
82MP0004885_abnormal_endolymph1.25789489
83MP0002234_abnormal_pharynx_morphology1.23241773
84MP0002090_abnormal_vision1.22146413
85MP0005666_abnormal_adipose_tissue1.20276898
86MP0005645_abnormal_hypothalamus_physiol1.15975717
87MP0005551_abnormal_eye_electrophysiolog1.15907616
88MP0003633_abnormal_nervous_system1.15649465
89MP0002066_abnormal_motor_capabilities/c1.15616188
90MP0001958_emphysema1.15199279
91MP0003942_abnormal_urinary_system1.13437880
92MP0001984_abnormal_olfaction1.13119744
93MP0002837_dystrophic_cardiac_calcinosis1.13092375
94MP0005167_abnormal_blood-brain_barrier1.10905423
95MP0001664_abnormal_digestion1.08499062
96MP0001661_extended_life_span1.05365700
97MP0003385_abnormal_body_wall1.04844813
98MP0004130_abnormal_muscle_cell1.03596828
99MP0000762_abnormal_tongue_morphology1.03047430
100MP0002069_abnormal_eating/drinking_beha1.02510114
101MP0005187_abnormal_penis_morphology1.01769032
102MP0006276_abnormal_autonomic_nervous1.01370605
103MP0004215_abnormal_myocardial_fiber1.01366287
104MP0002152_abnormal_brain_morphology1.00091255
105MP0004085_abnormal_heartbeat0.99191403
106MP0002653_abnormal_ependyma_morphology0.98364312
107MP0004145_abnormal_muscle_electrophysio0.97599431
108MP0004043_abnormal_pH_regulation0.97113950
109MP0001348_abnormal_lacrimal_gland0.97065457
110MP0005623_abnormal_meninges_morphology0.95635401
111MP0005646_abnormal_pituitary_gland0.95585420
112MP0002896_abnormal_bone_mineralization0.94556968
113MP0001915_intracranial_hemorrhage0.92441714
114MP0002932_abnormal_joint_morphology0.92308602
115MP0003091_abnormal_cell_migration0.92051037
116MP0004036_abnormal_muscle_relaxation0.89527252
117MP0002332_abnormal_exercise_endurance0.89515047
118MP0004084_abnormal_cardiac_muscle0.88741737
119MP0001765_abnormal_ion_homeostasis0.88731804
120MP0002114_abnormal_axial_skeleton0.87833054
121MP0004484_altered_response_of0.86662540
122MP0006072_abnormal_retinal_apoptosis0.86659440
123MP0003631_nervous_system_phenotype0.86021533
124MP0005670_abnormal_white_adipose0.85528807
125MP0000747_muscle_weakness0.85274672
126MP0005410_abnormal_fertilization0.84062867
127MP0001730_embryonic_growth_arrest0.82966755
128MP0002972_abnormal_cardiac_muscle0.82075002
129MP0002877_abnormal_melanocyte_morpholog0.81981854
130MP0000569_abnormal_digit_pigmentation0.81459146
131MP0003115_abnormal_respiratory_system0.80495454
132MP0002229_neurodegeneration0.80077885
133MP0005503_abnormal_tendon_morphology0.80006908
134MP0003172_abnormal_lysosome_physiology0.79284840
135MP0002127_abnormal_cardiovascular_syste0.78766766
136MP0000462_abnormal_digestive_system0.78741453
137MP0005508_abnormal_skeleton_morphology0.78006824
138MP0000049_abnormal_middle_ear0.77805473
139MP0001346_abnormal_lacrimal_gland0.77512605
140MP0002116_abnormal_craniofacial_bone0.76802809
141MP0000631_abnormal_neuroendocrine_gland0.76316979
142MP0009250_abnormal_appendicular_skeleto0.75981394
143MP0005535_abnormal_body_temperature0.75722727
144MP0003634_abnormal_glial_cell0.75492960
145MP0000003_abnormal_adipose_tissue0.75336278
146MP0008872_abnormal_physiological_respon0.75196095
147MP0002925_abnormal_cardiovascular_devel0.74529821
148MP0008874_decreased_physiological_sensi0.74110157
149MP0009840_abnormal_foam_cell0.73826718
150MP0002089_abnormal_postnatal_growth/wei0.73404393
151MP0001299_abnormal_eye_distance/0.72986638
152MP0000266_abnormal_heart_morphology0.71614205
153MP0004510_myositis0.70878982
154MP0001614_abnormal_blood_vessel0.70195451
155MP0000467_abnormal_esophagus_morphology0.69957376
156MP0000428_abnormal_craniofacial_morphol0.68095628
157MP0003705_abnormal_hypodermis_morpholog0.67581873
158MP0009278_abnormal_bone_marrow0.66824399
159MP0005620_abnormal_muscle_contractility0.66728542
160MP0002697_abnormal_eye_size0.66648897
161MP0001944_abnormal_pancreas_morphology0.65724124
162MP0003075_altered_response_to0.65685573
163MP0000534_abnormal_ureter_morphology0.65299397
164MP0005394_taste/olfaction_phenotype0.63643854
165MP0005499_abnormal_olfactory_system0.63643854
166MP0003453_abnormal_keratinocyte_physiol0.63390887
167MP0002128_abnormal_blood_circulation0.63091088
168MP0003137_abnormal_impulse_conducting0.62481923
169MP0000604_amyloidosis0.61068363
170MP0003045_fibrosis0.60612002
171MP0005448_abnormal_energy_balance0.59788011
172MP0003123_paternal_imprinting0.59406734
173MP0003953_abnormal_hormone_level0.58215779

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.12649824
2Type 1 muscle fiber predominance (HP:0003803)4.72789975
3Focal motor seizures (HP:0011153)4.67462244
4Muscle fiber inclusion bodies (HP:0100299)4.58113318
5Visual hallucinations (HP:0002367)4.56399665
6Nemaline bodies (HP:0003798)4.53286436
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.51931598
8Focal seizures (HP:0007359)4.44274110
9Myopathic facies (HP:0002058)4.03316991
10Epileptic encephalopathy (HP:0200134)3.98781635
11Protrusio acetabuli (HP:0003179)3.95523393
12Round ear (HP:0100830)3.66427466
13Centrally nucleated skeletal muscle fibers (HP:0003687)3.58148841
14Progressive cerebellar ataxia (HP:0002073)3.48517992
15Abnormality of the lower motor neuron (HP:0002366)3.42945734
16Depression (HP:0000716)3.40921305
17Premature rupture of membranes (HP:0001788)3.39812781
18Ankle clonus (HP:0011448)3.35947338
19Hypercortisolism (HP:0001578)3.35118607
20Abnormality of skeletal muscle fiber size (HP:0012084)3.32429479
21Increased connective tissue (HP:0009025)3.31710872
22Supranuclear gaze palsy (HP:0000605)3.17677644
23Distal lower limb amyotrophy (HP:0008944)3.11315527
24Spinal rigidity (HP:0003306)3.10299129
25Febrile seizures (HP:0002373)3.07138171
26Action tremor (HP:0002345)3.06105115
27Mildly elevated creatine phosphokinase (HP:0008180)3.03659901
28Atonic seizures (HP:0010819)3.01495060
29Ventricular fibrillation (HP:0001663)2.99753265
30Absence seizures (HP:0002121)2.91930472
31Ulnar deviation of the wrist (HP:0003049)2.90724643
32Cerebral aneurysm (HP:0004944)2.89785901
33Exercise-induced muscle cramps (HP:0003710)2.86636029
34Generalized tonic-clonic seizures (HP:0002069)2.86064116
35Distal arthrogryposis (HP:0005684)2.84107643
36Distal lower limb muscle weakness (HP:0009053)2.82651519
37Abnormal social behavior (HP:0012433)2.80931026
38Impaired social interactions (HP:0000735)2.80931026
39Poor eye contact (HP:0000817)2.77312467
40Difficulty climbing stairs (HP:0003551)2.76713583
41Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.70271962
42Shallow orbits (HP:0000586)2.69393575
43Calcaneovalgus deformity (HP:0001848)2.68884918
44Urinary urgency (HP:0000012)2.67729068
45Postural instability (HP:0002172)2.66799769
46Abnormality of the calcaneus (HP:0008364)2.64401904
47Dialeptic seizures (HP:0011146)2.60018280
48Genetic anticipation (HP:0003743)2.58620699
49Impaired vibration sensation in the lower limbs (HP:0002166)2.57121655
50Dysdiadochokinesis (HP:0002075)2.52897156
51Hemiparesis (HP:0001269)2.49159148
52Ulnar bowing (HP:0003031)2.49065464
53Insomnia (HP:0100785)2.49052381
54Torticollis (HP:0000473)2.48560093
55Bundle branch block (HP:0011710)2.48558484
56Mutism (HP:0002300)2.46885238
57Anxiety (HP:0000739)2.46398825
58Stridor (HP:0010307)2.43384870
59Urinary bladder sphincter dysfunction (HP:0002839)2.43130167
60Deformed tarsal bones (HP:0008119)2.42386332
61Muscle fiber splitting (HP:0003555)2.41935727
62Obstructive sleep apnea (HP:0002870)2.41048712
63Achilles tendon contracture (HP:0001771)2.40229651
64Thin ribs (HP:0000883)2.38202154
65Turricephaly (HP:0000262)2.34758066
66EMG: myopathic abnormalities (HP:0003458)2.34281297
67Muscle stiffness (HP:0003552)2.33964872
68Truncal ataxia (HP:0002078)2.33670545
69Prolonged QT interval (HP:0001657)2.32996286
70Pointed chin (HP:0000307)2.27219376
71Broad face (HP:0000283)2.27149415
72Abnormal eating behavior (HP:0100738)2.26392524
73Central scotoma (HP:0000603)2.25475197
74Neoplasm of the heart (HP:0100544)2.23936192
75Dysmetric saccades (HP:0000641)2.21898158
76Epileptiform EEG discharges (HP:0011182)2.21734027
77Bradykinesia (HP:0002067)2.20183921
78Amblyopia (HP:0000646)2.19406051
79EEG with generalized epileptiform discharges (HP:0011198)2.19206550
80Asymmetric septal hypertrophy (HP:0001670)2.19199790
81Impaired smooth pursuit (HP:0007772)2.18915920
82Back pain (HP:0003418)2.18523745
83Hyporeflexia of lower limbs (HP:0002600)2.17534853
84Neck muscle weakness (HP:0000467)2.16834483
85Focal dystonia (HP:0004373)2.15914979
86Biconcave vertebral bodies (HP:0004586)2.15857327
87Abnormality of the Achilles tendon (HP:0005109)2.15375343
88Rhabdomyolysis (HP:0003201)2.14767051
89Dysmetria (HP:0001310)2.14581978
90Fragile skin (HP:0001030)2.14567377
91Hand muscle atrophy (HP:0009130)2.11472521
92Hemiplegia (HP:0002301)2.11276601
93Distal upper limb amyotrophy (HP:0007149)2.11184738
94Upper limb amyotrophy (HP:0009129)2.11184738
95Cervical subluxation (HP:0003308)2.10474303
96Scanning speech (HP:0002168)2.10269422
97Myoglobinuria (HP:0002913)2.09545818
98Shoulder girdle muscle weakness (HP:0003547)2.08935271
99Malignant hyperthermia (HP:0002047)2.08804683
100Agitation (HP:0000713)2.07773554
101Flat acetabular roof (HP:0003180)2.07392109
102Bulbar palsy (HP:0001283)2.06281899
103Abnormal EKG (HP:0003115)2.05920933
104Hypsarrhythmia (HP:0002521)2.05757934
105Exercise-induced myalgia (HP:0003738)2.05062166
106Slender build (HP:0001533)2.04921029
107Abnormality of ocular smooth pursuit (HP:0000617)2.04303576
108Enlarged penis (HP:0000040)2.03740680
109Status epilepticus (HP:0002133)2.03388510
110Hypoventilation (HP:0002791)2.02580050
111Lymphangioma (HP:0100764)2.02403030
112Difficulty running (HP:0009046)2.02386699
113Limb-girdle muscle atrophy (HP:0003797)2.02146982
114Disproportionate tall stature (HP:0001519)2.01783981
115Adrenal overactivity (HP:0002717)2.01257499
116Bladder diverticulum (HP:0000015)2.00705550
117Craniofacial dystonia (HP:0012179)1.99402247
118Annular pancreas (HP:0001734)1.99400066
119Hyperacusis (HP:0010780)1.97247440
120Cerebral inclusion bodies (HP:0100314)1.96262027
121Clonus (HP:0002169)1.95937974
122Drooling (HP:0002307)1.94926050
123Excessive salivation (HP:0003781)1.94926050
124Amyotrophic lateral sclerosis (HP:0007354)1.94433625
125Gaze-evoked nystagmus (HP:0000640)1.94398533
126Spastic gait (HP:0002064)1.94181039
127Deep venous thrombosis (HP:0002625)1.93980082
128Abnormality of the calf musculature (HP:0001430)1.92659319
129Scapular winging (HP:0003691)1.92594005
130Broad-based gait (HP:0002136)1.92394837
131Vertebral compression fractures (HP:0002953)1.91258781
132Stereotypic behavior (HP:0000733)1.89492288
133Lower limb muscle weakness (HP:0007340)1.89451723
134Long toe (HP:0010511)1.89296279
135Termporal pattern (HP:0011008)1.89087479
136Insidious onset (HP:0003587)1.89087479
137Elfin facies (HP:0004428)1.88343769
138Congenital hip dislocation (HP:0001374)1.87947740
139Rapidly progressive (HP:0003678)1.87876551
140Megalencephaly (HP:0001355)1.87334639
141Atrophic scars (HP:0001075)1.85307820
142Macroorchidism (HP:0000053)1.83920069
143Generalized amyotrophy (HP:0003700)1.83123934
144Resting tremor (HP:0002322)1.82412095
145Papilledema (HP:0001085)1.82307906
146Muscle hypertrophy of the lower extremities (HP:0008968)1.82249006
147Foot dorsiflexor weakness (HP:0009027)1.82105264
148Myotonia (HP:0002486)1.80366519
149Metatarsus adductus (HP:0001840)1.77616005
150Progressive inability to walk (HP:0002505)1.77330541
151Mitral regurgitation (HP:0001653)1.76860767
152Pelvic girdle muscle weakness (HP:0003749)1.76809050
153Abnormality of dentin (HP:0010299)1.75591437
154Abnormality of the musculature of the pelvis (HP:0001469)1.75343297
155Abnormality of the hip-girdle musculature (HP:0001445)1.75343297
156Abnormality of the foot musculature (HP:0001436)1.74059254
157Pheochromocytoma (HP:0002666)1.73920325
158Broad metatarsal (HP:0001783)1.73593167
159Growth hormone excess (HP:0000845)1.72233207
160EMG: neuropathic changes (HP:0003445)1.71747156
161Neurofibrillary tangles (HP:0002185)1.71256037
162Lower limb amyotrophy (HP:0007210)1.70320692
163Neuronal loss in central nervous system (HP:0002529)1.70209181
164Intention tremor (HP:0002080)1.69406106
165Increased variability in muscle fiber diameter (HP:0003557)1.69070235
166Arterial tortuosity (HP:0005116)1.68275313
167Hemorrhage of the eye (HP:0011885)1.67992806
168Pterygium (HP:0001059)1.67940223
169Breech presentation (HP:0001623)1.67813478
170Ankyloglossia (HP:0010296)1.67619622
171Apathy (HP:0000741)1.66740988
172Bronchomalacia (HP:0002780)1.66729023
173Blue sclerae (HP:0000592)1.66433742
174Easy fatigability (HP:0003388)1.65408226
175Hammertoe (HP:0001765)1.63824724
176Vascular tortuosity (HP:0004948)1.62884072
177Wormian bones (HP:0002645)1.60977472
178Rimmed vacuoles (HP:0003805)1.60761390
179Progressive muscle weakness (HP:0003323)1.60082824
180Lumbar hyperlordosis (HP:0002938)1.58747870
181Ventricular tachycardia (HP:0004756)1.58131179
182Adducted thumb (HP:0001181)1.57748885
183Calf muscle hypertrophy (HP:0008981)1.57101776
184Asymmetry of the thorax (HP:0001555)1.55826493
185Renal duplication (HP:0000075)1.54388997
186Limb-girdle muscle weakness (HP:0003325)1.53233405
187Subaortic stenosis (HP:0001682)1.52793000

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.69408231
2TTN3.57393046
3NTRK33.43942767
4EPHA43.17142313
5MARK12.83523886
6PRKD32.74369525
7KSR22.68259092
8SMG12.53668236
9DAPK22.44861032
10MINK12.44114460
11MAP3K42.44022929
12SIK12.38866772
13PAK62.25510689
14OBSCN2.21468020
15FGFR42.11839372
16LMTK22.04668624
17TRIB32.02849215
18KSR12.01952204
19CAMKK11.90692532
20MAP3K21.76017786
21MAP3K101.67573614
22RIPK11.65507800
23NTRK11.62046759
24MAP2K41.56528360
25PKN21.55498784
26ERN11.54936971
27NTRK21.51511505
28STK381.51387656
29MAP2K31.49775502
30TAOK11.43214950
31NEK11.42962943
32INSRR1.42220019
33PHKG11.42091608
34PHKG21.42091608
35MAP2K71.40929968
36DAPK11.35932971
37IRAK31.35806634
38EPHA21.35474269
39CDK121.34223579
40CDK51.33933681
41MAP3K111.33645408
42PDK41.27043095
43PDK31.27043095
44MAP3K121.26680720
45RET1.23692227
46MTOR1.13255236
47TYRO31.12436497
48PRKD21.11956853
49LATS21.10696508
50SCYL21.10096466
51MAP3K71.09036627
52NME21.05737786
53MARK21.04223831
54PAK41.00389947
55MAPK120.99302510
56PDK10.97244486
57PTK2B0.96331975
58BCKDK0.95900060
59SIK20.95002340
60CAMK10.95000399
61MAP3K10.94862876
62FER0.94044091
63EPHB20.93827809
64MET0.92763251
65MAP3K130.92272026
66PDPK10.91380872
67PDGFRA0.90778278
68UHMK10.89881355
69TIE10.89717703
70ARAF0.88494868
71PAK30.85529887
72PRKCH0.81615505
73MAP2K10.81364055
74STK110.81305958
75CDK190.80612278
76RAF10.79636821
77PRKCG0.79359271
78CAMKK20.78852820
79FES0.78326624
80MAP3K60.77690111
81MOS0.76458116
82LIMK10.75855577
83TESK10.73691527
84RPS6KA20.72963396
85CDK140.72482583
86CDK150.72315876
87EEF2K0.71927886
88CDK180.71528917
89MUSK0.71446259
90RIPK40.70319161
91CAMK1D0.69346053
92PTK20.68414041
93SGK2230.67232366
94SGK4940.67232366
95MAPK130.66681271
96DDR20.65867759
97RPS6KC10.64447332
98RPS6KL10.64447332
99AKT20.64274759
100PAK20.63872638
101PINK10.62640227
102BRAF0.62492351
103EPHB10.61877097
104SGK30.61732235
105CDK11A0.61256783
106CAMK2A0.59209184
107PRKCZ0.59041219
108CAMK2G0.58968006
109TAOK20.58572765
110CDC42BPA0.58566522
111GRK50.58392819
112BMX0.58071157
113DYRK1A0.57018071
114MST1R0.56892302
115ILK0.56794420
116PLK20.56721611
117PTK60.56619956
118NME10.55890138
119TNIK0.55823153
120ALK0.54719964
121KDR0.53888444
122CSNK1G20.52068386
123PRPF4B0.51452563
124CAMK40.50447271
125MAPK110.50023652
126WNK30.49752994
127PIM20.49465938
128DAPK30.48339432
129MAP2K60.48287649
130SGK10.48100036
131CAMK1G0.46584650
132ICK0.46473549
133MAPK100.45317779
134DYRK1B0.45292855
135PRKG20.45044438
136MAPKAPK30.44275641
137SGK20.44164403
138CAMK2B0.43229721
139RPS6KA30.42794520
140DMPK0.42127761
141MAP2K20.41951972
142RPS6KA60.40783324
143PDK20.40697712
144PRKAA10.39145446
145ROCK10.37089576
146TESK20.36482007

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.96646360
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.59509770
3Nicotine addiction_Homo sapiens_hsa050332.42506408
4Circadian entrainment_Homo sapiens_hsa047132.29712440
5Long-term potentiation_Homo sapiens_hsa047202.24239175
6Olfactory transduction_Homo sapiens_hsa047402.17109086
7Insulin secretion_Homo sapiens_hsa049112.15075057
8GABAergic synapse_Homo sapiens_hsa047272.14433508
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.04462940
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.03848258
11Amphetamine addiction_Homo sapiens_hsa050311.94762570
12Salivary secretion_Homo sapiens_hsa049701.94697580
13Glutamatergic synapse_Homo sapiens_hsa047241.92620194
14Morphine addiction_Homo sapiens_hsa050321.90653854
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.87693488
16Dopaminergic synapse_Homo sapiens_hsa047281.84376570
17Gastric acid secretion_Homo sapiens_hsa049711.82458603
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.82194617
19Fructose and mannose metabolism_Homo sapiens_hsa000511.76031214
20Biosynthesis of amino acids_Homo sapiens_hsa012301.75460582
21Cholinergic synapse_Homo sapiens_hsa047251.71683901
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.71654561
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66222583
24Renin secretion_Homo sapiens_hsa049241.65653729
25Sulfur relay system_Homo sapiens_hsa041221.60411814
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.58734941
27Oxytocin signaling pathway_Homo sapiens_hsa049211.56821063
28Notch signaling pathway_Homo sapiens_hsa043301.54392170
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50956678
30Other glycan degradation_Homo sapiens_hsa005111.50862803
31Focal adhesion_Homo sapiens_hsa045101.48008008
32Pentose phosphate pathway_Homo sapiens_hsa000301.40771933
33Cocaine addiction_Homo sapiens_hsa050301.39373287
34Arginine biosynthesis_Homo sapiens_hsa002201.39270773
35Gap junction_Homo sapiens_hsa045401.37567620
36ECM-receptor interaction_Homo sapiens_hsa045121.36691389
37Type II diabetes mellitus_Homo sapiens_hsa049301.36270041
38GnRH signaling pathway_Homo sapiens_hsa049121.35750489
39Long-term depression_Homo sapiens_hsa047301.33216513
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.32282285
41Taste transduction_Homo sapiens_hsa047421.31597039
42Calcium signaling pathway_Homo sapiens_hsa040201.29698692
43Prion diseases_Homo sapiens_hsa050201.28937745
44Arginine and proline metabolism_Homo sapiens_hsa003301.28627141
45Carbon metabolism_Homo sapiens_hsa012001.26470848
46Bladder cancer_Homo sapiens_hsa052191.25337141
47Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.24708611
48Chronic myeloid leukemia_Homo sapiens_hsa052201.24060915
49Pancreatic secretion_Homo sapiens_hsa049721.23258662
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22491429
51Estrogen signaling pathway_Homo sapiens_hsa049151.22216228
52Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15960257
53Glioma_Homo sapiens_hsa052141.15247693
54cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14280623
55Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11047373
56Serotonergic synapse_Homo sapiens_hsa047261.09757655
57Galactose metabolism_Homo sapiens_hsa000521.09551774
58cAMP signaling pathway_Homo sapiens_hsa040241.08321305
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07859014
60Vibrio cholerae infection_Homo sapiens_hsa051101.06953459
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04930199
62ErbB signaling pathway_Homo sapiens_hsa040121.03113842
63Thyroid hormone synthesis_Homo sapiens_hsa049181.02818273
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01230687
65Collecting duct acid secretion_Homo sapiens_hsa049660.97943124
66Melanogenesis_Homo sapiens_hsa049160.97468988
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96940914
68Proteoglycans in cancer_Homo sapiens_hsa052050.94895157
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.94765484
70Thyroid cancer_Homo sapiens_hsa052160.93567449
71mTOR signaling pathway_Homo sapiens_hsa041500.93454373
72Glucagon signaling pathway_Homo sapiens_hsa049220.93009760
73Dilated cardiomyopathy_Homo sapiens_hsa054140.92476355
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91990905
75Adherens junction_Homo sapiens_hsa045200.91423985
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89344278
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89084373
78Axon guidance_Homo sapiens_hsa043600.88193118
79Hippo signaling pathway_Homo sapiens_hsa043900.86981937
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.85454569
81VEGF signaling pathway_Homo sapiens_hsa043700.85092188
82Lysine degradation_Homo sapiens_hsa003100.84315387
83Dorso-ventral axis formation_Homo sapiens_hsa043200.84268943
84Endometrial cancer_Homo sapiens_hsa052130.83449192
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80216531
86Nitrogen metabolism_Homo sapiens_hsa009100.79962916
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.79655134
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.78950800
89Oocyte meiosis_Homo sapiens_hsa041140.78520758
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.75837540
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75282804
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.75095215
93Cardiac muscle contraction_Homo sapiens_hsa042600.73994854
94Bile secretion_Homo sapiens_hsa049760.73690323
95Basal cell carcinoma_Homo sapiens_hsa052170.73530506
96Insulin signaling pathway_Homo sapiens_hsa049100.73471733
97Amoebiasis_Homo sapiens_hsa051460.72343184
98Circadian rhythm_Homo sapiens_hsa047100.71913962
99Acute myeloid leukemia_Homo sapiens_hsa052210.70844789
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70226502
101Non-small cell lung cancer_Homo sapiens_hsa052230.69322426
102Small cell lung cancer_Homo sapiens_hsa052220.68184119
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68174948
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65647190
105Choline metabolism in cancer_Homo sapiens_hsa052310.63306556
106Pancreatic cancer_Homo sapiens_hsa052120.63128731
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62800060
108Endocytosis_Homo sapiens_hsa041440.62158016
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.60492138
110Vitamin B6 metabolism_Homo sapiens_hsa007500.60389334
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59591355
112MicroRNAs in cancer_Homo sapiens_hsa052060.58332997
113Rap1 signaling pathway_Homo sapiens_hsa040150.58049052
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57503115
115Phenylalanine metabolism_Homo sapiens_hsa003600.55825049
116Protein digestion and absorption_Homo sapiens_hsa049740.55774236
117Inositol phosphate metabolism_Homo sapiens_hsa005620.54188838
118MAPK signaling pathway_Homo sapiens_hsa040100.54063742
119Prolactin signaling pathway_Homo sapiens_hsa049170.51540725
120AMPK signaling pathway_Homo sapiens_hsa041520.50830893
121Fatty acid metabolism_Homo sapiens_hsa012120.49965206
122Renal cell carcinoma_Homo sapiens_hsa052110.49391945
123Colorectal cancer_Homo sapiens_hsa052100.49149148
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48919080
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48395767
126Phototransduction_Homo sapiens_hsa047440.46553684
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46535714
128Ras signaling pathway_Homo sapiens_hsa040140.43873983
129Insulin resistance_Homo sapiens_hsa049310.43645312
130Wnt signaling pathway_Homo sapiens_hsa043100.41775140
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.40653063
132Mineral absorption_Homo sapiens_hsa049780.40539345
133Tight junction_Homo sapiens_hsa045300.40181887
1342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40021075
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40010185
136Platelet activation_Homo sapiens_hsa046110.39461504
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.39450374
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39299568
139HIF-1 signaling pathway_Homo sapiens_hsa040660.39280119
140Alcoholism_Homo sapiens_hsa050340.38753849

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