STK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory C-terminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.67538118
2tryptophan catabolic process (GO:0006569)4.69653723
3indole-containing compound catabolic process (GO:0042436)4.69653723
4indolalkylamine catabolic process (GO:0046218)4.69653723
5kynurenine metabolic process (GO:0070189)4.50516713
6protein K11-linked deubiquitination (GO:0035871)4.38882443
7detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.38086556
8indolalkylamine metabolic process (GO:0006586)4.33450946
9behavioral response to nicotine (GO:0035095)4.32651417
10cilium or flagellum-dependent cell motility (GO:0001539)4.11639848
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.11603285
12tryptophan metabolic process (GO:0006568)4.03317519
13regulation of nuclear cell cycle DNA replication (GO:0033262)3.95093199
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.94741955
15seminiferous tubule development (GO:0072520)3.93453056
16mitotic metaphase plate congression (GO:0007080)3.86160650
17nuclear pore organization (GO:0006999)3.85623634
18kinetochore organization (GO:0051383)3.78644601
19negative regulation of DNA-dependent DNA replication (GO:2000104)3.75536752
20nuclear pore complex assembly (GO:0051292)3.71836365
21mitotic chromosome condensation (GO:0007076)3.69521255
22detection of light stimulus involved in sensory perception (GO:0050962)3.66907767
23detection of light stimulus involved in visual perception (GO:0050908)3.66907767
24negative regulation of cytosolic calcium ion concentration (GO:0051481)3.63313764
25intra-S DNA damage checkpoint (GO:0031573)3.62845997
26mitotic sister chromatid cohesion (GO:0007064)3.61508755
27metaphase plate congression (GO:0051310)3.60282751
28response to pheromone (GO:0019236)3.59361459
29protein localization to kinetochore (GO:0034501)3.58919837
30notochord development (GO:0030903)3.47965962
31positive regulation of mitotic sister chromatid separation (GO:1901970)3.47963569
32positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.47963569
33positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.47963569
34cilium movement (GO:0003341)3.45206410
35L-fucose catabolic process (GO:0042355)3.43890404
36fucose catabolic process (GO:0019317)3.43890404
37L-fucose metabolic process (GO:0042354)3.43890404
38photoreceptor cell maintenance (GO:0045494)3.43833040
39cellular biogenic amine catabolic process (GO:0042402)3.34862072
40amine catabolic process (GO:0009310)3.34862072
41attachment of spindle microtubules to kinetochore (GO:0008608)3.34082127
42establishment of chromosome localization (GO:0051303)3.32275780
43regulation of transforming growth factor beta2 production (GO:0032909)3.24652476
44regulation of sister chromatid cohesion (GO:0007063)3.24026071
45cellular ketone body metabolic process (GO:0046950)3.23601380
46chondrocyte proliferation (GO:0035988)3.23284863
47regulation of spindle organization (GO:0090224)3.21992925
48establishment of protein localization to Golgi (GO:0072600)3.21007149
49sister chromatid segregation (GO:0000819)3.19999898
50detection of chemical stimulus involved in sensory perception (GO:0050907)3.17948875
51epithelial cilium movement (GO:0003351)3.17751808
52left/right axis specification (GO:0070986)3.14560104
53definitive hemopoiesis (GO:0060216)3.14176069
54behavioral response to ethanol (GO:0048149)3.12926366
55reflex (GO:0060004)3.12498987
56kinetochore assembly (GO:0051382)3.11545253
57indole-containing compound metabolic process (GO:0042430)3.07364860
58regulation of cilium movement (GO:0003352)3.07237380
59cilium morphogenesis (GO:0060271)3.06471078
60regulation of mitotic spindle organization (GO:0060236)3.05170384
61DNA methylation involved in gamete generation (GO:0043046)3.03068001
62axonemal dynein complex assembly (GO:0070286)3.02331447
63mitotic nuclear envelope disassembly (GO:0007077)3.02262095
64cilium organization (GO:0044782)3.02092129
65piRNA metabolic process (GO:0034587)3.00055817
66aromatic amino acid family catabolic process (GO:0009074)2.99772995
67meiotic chromosome segregation (GO:0045132)2.99201387
68spindle checkpoint (GO:0031577)2.98503095
69regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98329993
70DNA topological change (GO:0006265)2.97947593
71cilium assembly (GO:0042384)2.97328834
72ketone body metabolic process (GO:1902224)2.97199523
73protein localization to chromosome, centromeric region (GO:0071459)2.96467972
74oxidative demethylation (GO:0070989)2.94691262
75regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94688688
76fibroblast migration (GO:0010761)2.92370474
77pore complex assembly (GO:0046931)2.91885197
78mitotic sister chromatid segregation (GO:0000070)2.91268475
79righting reflex (GO:0060013)2.90875869
80dendritic spine morphogenesis (GO:0060997)2.88314230
81interkinetic nuclear migration (GO:0022027)2.88229572
82spindle assembly checkpoint (GO:0071173)2.87239236
83mitotic G2/M transition checkpoint (GO:0044818)2.86863203
84phosphatidylinositol acyl-chain remodeling (GO:0036149)2.85627074
85paraxial mesoderm development (GO:0048339)2.85276007
86protein polyglutamylation (GO:0018095)2.85083832
87preassembly of GPI anchor in ER membrane (GO:0016254)2.84078990
88parturition (GO:0007567)2.84009477
89collagen fibril organization (GO:0030199)2.83808698
90DNA unwinding involved in DNA replication (GO:0006268)2.83788499
91multicellular organism reproduction (GO:0032504)2.83535193
92nonmotile primary cilium assembly (GO:0035058)2.82920602
93cellular response to ATP (GO:0071318)2.82459791
94membrane disassembly (GO:0030397)2.81990326
95nuclear envelope disassembly (GO:0051081)2.81990326
96retina layer formation (GO:0010842)2.81519812
97maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79214951
98regulation of mesoderm development (GO:2000380)2.79178068
99mitotic spindle checkpoint (GO:0071174)2.79153851
100embryonic process involved in female pregnancy (GO:0060136)2.78851414
101mitotic spindle assembly checkpoint (GO:0007094)2.78206400
102tooth mineralization (GO:0034505)2.78115589
103regulation of mitotic sister chromatid separation (GO:0010965)2.77414622
104regulation of mitotic sister chromatid segregation (GO:0033047)2.77414622
105regulation of sister chromatid segregation (GO:0033045)2.77414622
106negative regulation of chromosome segregation (GO:0051985)2.76831580
107negative regulation of mitotic sister chromatid separation (GO:2000816)2.76717508
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.76717508
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.76717508
110negative regulation of sister chromatid segregation (GO:0033046)2.76717508
111cornea development in camera-type eye (GO:0061303)2.75457267
112protein localization to Golgi apparatus (GO:0034067)2.74821106
113positive regulation of chromosome segregation (GO:0051984)2.74755144
114nephron epithelium morphogenesis (GO:0072088)2.74404824
115nephron tubule morphogenesis (GO:0072078)2.74404824
116intraciliary transport (GO:0042073)2.73307886
117water-soluble vitamin biosynthetic process (GO:0042364)2.72745675
118axoneme assembly (GO:0035082)2.72731325
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72640893
120cell adhesion mediated by integrin (GO:0033627)2.71509450
121* hippo signaling (GO:0035329)2.70581591
122sperm motility (GO:0030317)2.70500747
123chromosome segregation (GO:0007059)2.69548093
124regulation of centrosome cycle (GO:0046605)2.68127194
125benzene-containing compound metabolic process (GO:0042537)2.68042712
126regulation of hippo signaling (GO:0035330)2.65654180
127regulation of chromosome segregation (GO:0051983)2.65176466
128negative regulation of systemic arterial blood pressure (GO:0003085)2.65110443
129monoubiquitinated protein deubiquitination (GO:0035520)2.63887108
130tachykinin receptor signaling pathway (GO:0007217)2.62184075
131detection of mechanical stimulus involved in sensory perception (GO:0050974)2.61281251
132photoreceptor cell development (GO:0042461)2.59871389
133aromatic amino acid family metabolic process (GO:0009072)2.58231029
134regulation of centriole replication (GO:0046599)2.57898824
135reciprocal meiotic recombination (GO:0007131)2.56210634
136reciprocal DNA recombination (GO:0035825)2.56210634
137phosphatidylserine acyl-chain remodeling (GO:0036150)2.55335748
138sex differentiation (GO:0007548)2.54504315
139regulation of cellular senescence (GO:2000772)2.53900599
140synaptic transmission, cholinergic (GO:0007271)2.52643233
141regulation of sarcomere organization (GO:0060297)2.51780039
142CENP-A containing nucleosome assembly (GO:0034080)2.51519978
143mitotic G2 DNA damage checkpoint (GO:0007095)2.51452508
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51046565
145positive regulation of epithelial to mesenchymal transition (GO:0010718)2.50449289
146snRNA transcription (GO:0009301)2.47902438
147protein targeting to Golgi (GO:0000042)2.46514860
148double-strand break repair via homologous recombination (GO:0000724)2.46266819
149regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.45674233
150negative regulation of mast cell activation (GO:0033004)2.45402985
151regulation of establishment of cell polarity (GO:2000114)2.44938608
152recombinational repair (GO:0000725)2.44461931
153cellular component assembly involved in morphogenesis (GO:0010927)2.44198920
154detection of chemical stimulus (GO:0009593)2.44139175
155auditory receptor cell differentiation (GO:0042491)2.43628362
156thyroid hormone metabolic process (GO:0042403)2.42147239
157mitotic recombination (GO:0006312)2.41626391
158regulation of centrosome duplication (GO:0010824)2.41302242
159centriole replication (GO:0007099)2.41107902
160limb development (GO:0060173)2.41104307
161appendage development (GO:0048736)2.41104307
162chromatin remodeling at centromere (GO:0031055)2.40915980
163auditory receptor cell stereocilium organization (GO:0060088)2.40173677
164eye photoreceptor cell development (GO:0042462)2.39042137
165primary amino compound metabolic process (GO:1901160)2.37554759
166negative regulation of multicellular organism growth (GO:0040015)2.37263951
167DNA replication checkpoint (GO:0000076)2.36037287
168mitotic DNA integrity checkpoint (GO:0044774)2.35859301
169germ cell migration (GO:0008354)2.34581389
170metanephric mesenchyme development (GO:0072075)2.30501605
171regulation of SMAD protein import into nucleus (GO:0060390)2.28445663
172glucocorticoid receptor signaling pathway (GO:0042921)2.27983525
173protein localization to chromosome (GO:0034502)2.27387378
174mesodermal cell differentiation (GO:0048333)2.26980495
175dosage compensation (GO:0007549)2.23339879
176negative regulation of mitosis (GO:0045839)2.20964184
177kidney mesenchyme development (GO:0072074)2.20456507
178telomere maintenance via recombination (GO:0000722)2.19287300
179regulation of cell aging (GO:0090342)2.18731335
180corticosteroid receptor signaling pathway (GO:0031958)2.18204655
181DNA replication initiation (GO:0006270)2.17240741
182outer ear morphogenesis (GO:0042473)2.17007195
183DNA replication-independent nucleosome organization (GO:0034724)2.16930095
184DNA replication-independent nucleosome assembly (GO:0006336)2.16930095
185neural crest cell development (GO:0014032)2.15915872
186histone-serine phosphorylation (GO:0035404)2.15805427
187replication fork processing (GO:0031297)2.14858520
188myoblast migration (GO:0051451)2.14068944
189artery development (GO:0060840)2.13352458
190negative regulation of chondrocyte differentiation (GO:0032331)2.12676790
191G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.12300720
192mesenchymal-epithelial cell signaling (GO:0060638)2.12281935
193positive regulation of stem cell differentiation (GO:2000738)2.11259012
194positive regulation of extracellular matrix organization (GO:1903055)2.11257361
195negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.11164500
196nuclear envelope organization (GO:0006998)2.10319783
197endodermal cell differentiation (GO:0035987)2.10092318
198lymph vessel development (GO:0001945)2.09022650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.77104903
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.06106332
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.99933108
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.82740222
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.76910595
6VDR_22108803_ChIP-Seq_LS180_Human3.56935503
7ZNF274_21170338_ChIP-Seq_K562_Hela3.51808171
8AR_21909140_ChIP-Seq_LNCAP_Human3.43106023
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22645028
10GBX2_23144817_ChIP-Seq_PC3_Human3.12266636
11TRIM28_21343339_ChIP-Seq_HEK293_Human3.02219942
12EZH2_22144423_ChIP-Seq_EOC_Human3.02208629
13SALL1_21062744_ChIP-ChIP_HESCs_Human3.00876784
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.72393064
15* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.71256475
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62143678
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.59977059
18IGF1R_20145208_ChIP-Seq_DFB_Human2.59463792
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.52407068
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38952073
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.37262932
22CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.26417144
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21407636
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19894201
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.15124941
26TAF15_26573619_Chip-Seq_HEK293_Human2.14389000
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.12490457
28CTBP1_25329375_ChIP-Seq_LNCAP_Human2.11234888
29P300_19829295_ChIP-Seq_ESCs_Human2.05459700
30ER_23166858_ChIP-Seq_MCF-7_Human1.98574421
31ELK1_19687146_ChIP-ChIP_HELA_Human1.97457333
32CLOCK_20551151_ChIP-Seq_293T_Human1.96622040
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.95597530
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.95109152
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91986352
36BRD4_25478319_ChIP-Seq_HGPS_Human1.91488930
37TP63_19390658_ChIP-ChIP_HaCaT_Human1.91000033
38BCAT_22108803_ChIP-Seq_LS180_Human1.88123041
39* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.86223501
40* STAT3_23295773_ChIP-Seq_U87_Human1.81231375
41UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.80595209
42WT1_19549856_ChIP-ChIP_CCG9911_Human1.79736216
43SMAD4_21799915_ChIP-Seq_A2780_Human1.77339889
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77279993
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76735084
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.76225686
47IRF1_19129219_ChIP-ChIP_H3396_Human1.72998534
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72305542
49TP63_17297297_ChIP-ChIP_HaCaT_Human1.71882768
50CBP_20019798_ChIP-Seq_JUKART_Human1.71461090
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.71461090
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70926991
53PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.69228020
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.67621444
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.66419900
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63474320
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62649539
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62649539
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.61869987
60* AR_25329375_ChIP-Seq_VCAP_Human1.61059514
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58648580
62AR_21572438_ChIP-Seq_LNCaP_Human1.58636160
63TCF4_23295773_ChIP-Seq_U87_Human1.56479730
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.54823605
65* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51330056
66PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50809903
67RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47968007
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46931379
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.45657698
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45170448
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.44418104
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44248312
73* CJUN_26792858_Chip-Seq_BT549_Human1.44026771
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43441255
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42484994
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.41439594
77SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40621276
78SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40621276
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39550336
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39127411
81TP53_16413492_ChIP-PET_HCT116_Human1.37534059
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37294975
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.35238211
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.34550620
85* TCF4_22108803_ChIP-Seq_LS180_Human1.34539312
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.33885408
87EWS_26573619_Chip-Seq_HEK293_Human1.32837682
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30721687
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29817960
90SMAD4_21741376_ChIP-Seq_EPCs_Human1.29162134
91CDX2_22108803_ChIP-Seq_LS180_Human1.27692774
92* RUNX2_22187159_ChIP-Seq_PCA_Human1.27469524
93HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27287806
94SOX2_19829295_ChIP-Seq_ESCs_Human1.26729444
95NANOG_19829295_ChIP-Seq_ESCs_Human1.26729444
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.25912301
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25808028
98TFEB_21752829_ChIP-Seq_HELA_Human1.25703113
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25697449
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25375210
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.25319965
102NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.25085570
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24757294
104IRF8_22096565_ChIP-ChIP_GC-B_Human1.24179639
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24117147
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23845754
107REST_21632747_ChIP-Seq_MESCs_Mouse1.21418483
108* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19815888
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19791685
110TP53_22573176_ChIP-Seq_HFKS_Human1.19764870
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.19365908
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.19345480
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19256285
114ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19142199
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.19119199
116FLI1_21867929_ChIP-Seq_TH2_Mouse1.17172881
117RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16770142
118P53_22387025_ChIP-Seq_ESCs_Mouse1.15930495
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.15665151
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15114008
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.15114008
122EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15020083
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14807438
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13541979
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13416537
126RARG_19884340_ChIP-ChIP_MEFs_Mouse1.11965696
127RNF2_27304074_Chip-Seq_NSC_Mouse1.09597703
128* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08536369
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.08300373
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08237046
131AHR_22903824_ChIP-Seq_MCF-7_Human1.07987929
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07920477
133* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07855822
134KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07827531
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06790168
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06367816
137SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06325033
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.06251603
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05722482
140TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05598851
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05466378
142Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05188636
143TBL1_22424771_ChIP-Seq_293T_Human1.04646634
144FUS_26573619_Chip-Seq_HEK293_Human1.04616545
145* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04328878
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04060219
147* KDM2B_26808549_Chip-Seq_REH_Human1.03100474
148JUN_21703547_ChIP-Seq_K562_Human1.02588558
149GATA4_21415370_ChIP-Seq_HL-1_Mouse1.01971529
150NCOR_22424771_ChIP-Seq_293T_Human1.01510772
151* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01231114
152HOXB7_26014856_ChIP-Seq_BT474_Human1.01013227
153MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00035621
154ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99931849
155NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99733207
156UBF1/2_26484160_Chip-Seq_HMECs_Human0.99494512
157SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95382580
158MYCN_18555785_ChIP-Seq_MESCs_Mouse0.95004092
159* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90372106
160EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90265568
161* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.89174709
162NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89127660
163NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89127660
164* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88717396
165STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88591599
166SOX2_20726797_ChIP-Seq_SW620_Human0.87757517
167PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87028171
168POU5F1_16153702_ChIP-ChIP_HESCs_Human0.85296161
169POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84608348
170TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84413448
171* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84326144
172* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84197738
173ESR1_20079471_ChIP-ChIP_T-47D_Human0.84163085
174TCF4_18268006_ChIP-ChIP_LS174T_Human0.83932945
175SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.82205431
176* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81830739
177* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.81183247
178CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80471559
179IRF8_27001747_Chip-Seq_BMDM_Mouse0.80160528
180STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.79407401
181TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79381605
182RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78873142
183GATA2_21666600_ChIP-Seq_HMVEC_Human0.78839919
184KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78753171
185SOX17_20123909_ChIP-Seq_XEN_Mouse0.78543547
186ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78285933
187FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78264133
188MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.78100895
189ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78024986
190IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.77634099
191NANOG_16153702_ChIP-ChIP_HESCs_Human0.77591590
192DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.76366736
193YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.75309026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.67677458
2MP0002837_dystrophic_cardiac_calcinosis3.12456052
3MP0003136_yellow_coat_color3.10389359
4MP0005084_abnormal_gallbladder_morpholo2.84077331
5MP0000569_abnormal_digit_pigmentation2.78743071
6MP0003705_abnormal_hypodermis_morpholog2.70461290
7MP0003646_muscle_fatigue2.61846442
8MP0005503_abnormal_tendon_morphology2.59984366
9MP0002653_abnormal_ependyma_morphology2.55515172
10MP0005551_abnormal_eye_electrophysiolog2.52866026
11MP0006054_spinal_hemorrhage2.40277450
12MP0003195_calcinosis2.39498826
13MP0002163_abnormal_gland_morphology2.33901770
14MP0006072_abnormal_retinal_apoptosis2.19317843
15MP0008007_abnormal_cellular_replicative2.19134614
16MP0003787_abnormal_imprinting2.18778238
17MP0006292_abnormal_olfactory_placode2.11238018
18MP0005379_endocrine/exocrine_gland_phen2.07635972
19MP0005275_abnormal_skin_tensile2.04620725
20MP0003941_abnormal_skin_development2.02638943
21MP0000427_abnormal_hair_cycle2.00951425
22MP0010352_gastrointestinal_tract_polyps2.00848970
23MP0004272_abnormal_basement_membrane2.00662655
24MP0005646_abnormal_pituitary_gland2.00090179
25MP0002102_abnormal_ear_morphology1.99227158
26MP0001485_abnormal_pinna_reflex1.98792921
27MP0003950_abnormal_plasma_membrane1.94824129
28MP0002282_abnormal_trachea_morphology1.84219906
29MP0005253_abnormal_eye_physiology1.82974512
30MP0009053_abnormal_anal_canal1.80306893
31MP0010030_abnormal_orbit_morphology1.76241526
32MP0003123_paternal_imprinting1.74612103
33MP0001968_abnormal_touch/_nociception1.73295392
34MP0004133_heterotaxia1.72307137
35MP0003077_abnormal_cell_cycle1.72271421
36MP0006276_abnormal_autonomic_nervous1.71881329
37MP0003566_abnormal_cell_adhesion1.71592677
38MP0005174_abnormal_tail_pigmentation1.70498272
39MP0010094_abnormal_chromosome_stability1.67943483
40MP0009780_abnormal_chondrocyte_physiolo1.67194223
41MP0000372_irregular_coat_pigmentation1.64744443
42MP0009697_abnormal_copulation1.63640666
43MP0008961_abnormal_basal_metabolism1.62690377
44MP0003111_abnormal_nucleus_morphology1.61577840
45MP0005623_abnormal_meninges_morphology1.59956120
46MP0004808_abnormal_hematopoietic_stem1.58298964
47MP0003252_abnormal_bile_duct1.56431880
48MP0003121_genomic_imprinting1.54500001
49MP0002876_abnormal_thyroid_physiology1.53968882
50MP0009046_muscle_twitch1.53608270
51MP0002736_abnormal_nociception_after1.52997351
52MP0004957_abnormal_blastocyst_morpholog1.52097601
53MP0004130_abnormal_muscle_cell1.51383988
54MP0005023_abnormal_wound_healing1.50881054
55MP0005508_abnormal_skeleton_morphology1.50779283
56MP0001879_abnormal_lymphatic_vessel1.50634609
57MP0008057_abnormal_DNA_replication1.50423528
58MP0002009_preneoplasia1.49919685
59MP0003011_delayed_dark_adaptation1.49772741
60MP0001986_abnormal_taste_sensitivity1.48350355
61MP0000383_abnormal_hair_follicle1.47406763
62MP0002877_abnormal_melanocyte_morpholog1.47346762
63MP0010307_abnormal_tumor_latency1.43887358
64MP0003091_abnormal_cell_migration1.42676828
65MP0008872_abnormal_physiological_respon1.42351493
66MP0010368_abnormal_lymphatic_system1.41882643
67MP0003937_abnormal_limbs/digits/tail_de1.41647363
68MP0009250_abnormal_appendicular_skeleto1.39613792
69MP0005377_hearing/vestibular/ear_phenot1.38062844
70MP0003878_abnormal_ear_physiology1.38062844
71MP0004043_abnormal_pH_regulation1.36516347
72MP0005410_abnormal_fertilization1.32983080
73MP0004142_abnormal_muscle_tone1.32779683
74MP0009384_cardiac_valve_regurgitation1.32695109
75MP0000767_abnormal_smooth_muscle1.32526836
76MP0003385_abnormal_body_wall1.31346013
77MP0005076_abnormal_cell_differentiation1.31168924
78MP0002638_abnormal_pupillary_reflex1.30445449
79MP0003279_aneurysm1.29743298
80MP0002928_abnormal_bile_duct1.29096112
81MP0005248_abnormal_Harderian_gland1.28143823
82MP0005195_abnormal_posterior_eye1.27708755
83MP0003693_abnormal_embryo_hatching1.27111686
84MP0000631_abnormal_neuroendocrine_gland1.26446157
85MP0003880_abnormal_central_pattern1.25241046
86MP0002095_abnormal_skin_pigmentation1.22795796
87MP0000733_abnormal_muscle_development1.22493454
88MP0003718_maternal_effect1.20941527
89MP0002396_abnormal_hematopoietic_system1.20713200
90MP0002160_abnormal_reproductive_system1.18089146
91MP0003942_abnormal_urinary_system1.15986147
92MP0001915_intracranial_hemorrhage1.15667088
93MP0001958_emphysema1.15604393
94MP0004145_abnormal_muscle_electrophysio1.15178629
95MP0001501_abnormal_sleep_pattern1.14976947
96MP0008932_abnormal_embryonic_tissue1.13607246
97MP0009745_abnormal_behavioral_response1.12870581
98MP0000537_abnormal_urethra_morphology1.12766833
99MP0003567_abnormal_fetal_cardiomyocyte1.12477775
100MP0001293_anophthalmia1.12268666
101MP0009278_abnormal_bone_marrow1.10983159
102MP0000428_abnormal_craniofacial_morphol1.10647976
103MP0000371_diluted_coat_color1.10617168
104MP0002234_abnormal_pharynx_morphology1.09767212
105MP0003943_abnormal_hepatobiliary_system1.08280658
106MP0002272_abnormal_nervous_system1.07867600
107MP0003755_abnormal_palate_morphology1.07354080
108MP0008875_abnormal_xenobiotic_pharmacok1.06985637
109MP0004147_increased_porphyrin_level1.05826539
110* MP0002115_abnormal_skeleton_extremities1.05321452
111MP0001545_abnormal_hematopoietic_system1.05143573
112MP0005397_hematopoietic_system_phenotyp1.05143573
113MP0002557_abnormal_social/conspecific_i1.04914026
114MP0005171_absent_coat_pigmentation1.03911918
115* MP0000350_abnormal_cell_proliferation1.03599728
116MP0001486_abnormal_startle_reflex1.03248736
117MP0002138_abnormal_hepatobiliary_system1.03228765
118* MP0002086_abnormal_extraembryonic_tissu1.02385478
119MP0004924_abnormal_behavior1.02367971
120MP0005386_behavior/neurological_phenoty1.02367971
121MP0002572_abnormal_emotion/affect_behav1.02281666
122* MP0002113_abnormal_skeleton_development1.02223867
123MP0005448_abnormal_energy_balance1.01237555
124* MP0003984_embryonic_growth_retardation1.00961493
125MP0005389_reproductive_system_phenotype1.00533320
126MP0004197_abnormal_fetal_growth/weight/1.00136675
127* MP0005380_embryogenesis_phenotype1.00024392
128* MP0001672_abnormal_embryogenesis/_devel1.00024392
129* MP0005390_skeleton_phenotype0.99919881
130* MP0002088_abnormal_embryonic_growth/wei0.99823803
131MP0003890_abnormal_embryonic-extraembry0.99816294
132MP0003828_pulmonary_edema0.98851459
133MP0002006_tumorigenesis0.98722821
134MP0000230_abnormal_systemic_arterial0.98053327
135MP0005167_abnormal_blood-brain_barrier0.97991641
136MP0002752_abnormal_somatic_nervous0.97504099
137* MP0002109_abnormal_limb_morphology0.96767097
138MP0002938_white_spotting0.96625183
139MP0000432_abnormal_head_morphology0.95879888
140* MP0001697_abnormal_embryo_size0.95594831
141* MP0000163_abnormal_cartilage_morphology0.95420267
142MP0003935_abnormal_craniofacial_develop0.95210807
143* MP0002925_abnormal_cardiovascular_devel0.94374146
144MP0005645_abnormal_hypothalamus_physiol0.94212507
145MP0001324_abnormal_eye_pigmentation0.94151439
146MP0003115_abnormal_respiratory_system0.92509305
147MP0001730_embryonic_growth_arrest0.92250056
148MP0004885_abnormal_endolymph0.92012016
149MP0004215_abnormal_myocardial_fiber0.91997755
150MP0005367_renal/urinary_system_phenotyp0.91863341
151MP0000516_abnormal_urinary_system0.91863341
152MP0002060_abnormal_skin_morphology0.91563381
153MP0008775_abnormal_heart_ventricle0.91396574
154MP0000778_abnormal_nervous_system0.91177412
155* MP0002085_abnormal_embryonic_tissue0.90513731
156MP0000534_abnormal_ureter_morphology0.90151728
157MP0000026_abnormal_inner_ear0.89828708
158MP0003786_premature_aging0.89757664
159MP0001346_abnormal_lacrimal_gland0.88391878
160MP0010386_abnormal_urinary_bladder0.87290734
161MP0000015_abnormal_ear_pigmentation0.87069543
162MP0000490_abnormal_crypts_of0.86891940
163MP0002166_altered_tumor_susceptibility0.86875901
164MP0002733_abnormal_thermal_nociception0.86854395
165MP0005391_vision/eye_phenotype0.86824871
166* MP0001614_abnormal_blood_vessel0.86721698
167MP0002295_abnormal_pulmonary_circulatio0.86082587
168MP0008877_abnormal_DNA_methylation0.85348382
169MP0004742_abnormal_vestibular_system0.85333529
170MP0005220_abnormal_exocrine_pancreas0.85316399
171* MP0002084_abnormal_developmental_patter0.84729395
172MP0002932_abnormal_joint_morphology0.84345268
173MP0002249_abnormal_larynx_morphology0.84340096
174MP0001119_abnormal_female_reproductive0.84274986
175MP0003698_abnormal_male_reproductive0.84088407
176MP0003448_altered_tumor_morphology0.84038508
177MP0002229_neurodegeneration0.83914698
178MP0001175_abnormal_lung_morphology0.83768840
179MP0001970_abnormal_pain_threshold0.83684402
180MP0000049_abnormal_middle_ear0.83601265
181MP0005408_hypopigmentation0.83306913
182MP0002128_abnormal_blood_circulation0.82163633
183MP0001963_abnormal_hearing_physiology0.81641255
184MP0010678_abnormal_skin_adnexa0.81501400
185MP0003183_abnormal_peptide_metabolism0.81291929
186MP0003879_abnormal_hair_cell0.80969351
187MP0008058_abnormal_DNA_repair0.80398887
188MP0002896_abnormal_bone_mineralization0.79185838
189MP0002075_abnormal_coat/hair_pigmentati0.77960438
190MP0002184_abnormal_innervation0.77698768
191MP0000566_synostosis0.75655840

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)4.51381398
2Abnormality of midbrain morphology (HP:0002418)4.49331565
3Molar tooth sign on MRI (HP:0002419)4.49331565
4Pancreatic cysts (HP:0001737)4.43872686
5Nephronophthisis (HP:0000090)4.39097038
6Protrusio acetabuli (HP:0003179)4.12711618
7True hermaphroditism (HP:0010459)4.06889505
8Abnormality of the renal medulla (HP:0100957)3.87461472
9Ankle contracture (HP:0006466)3.57332668
10Chronic hepatic failure (HP:0100626)3.51663273
11Congenital stationary night blindness (HP:0007642)3.42310222
12Medial flaring of the eyebrow (HP:0010747)3.39312283
13Cervical subluxation (HP:0003308)3.34223221
14Genetic anticipation (HP:0003743)3.33890250
15Tubular atrophy (HP:0000092)3.31026624
16Premature rupture of membranes (HP:0001788)3.24129894
17Abnormality of the renal cortex (HP:0011035)3.22335305
18Progressive cerebellar ataxia (HP:0002073)3.16467243
19Syringomyelia (HP:0003396)3.04846794
20Spinal cord lesions (HP:0100561)3.04846794
21Aortic dissection (HP:0002647)3.02602667
22Hyperventilation (HP:0002883)2.97878798
23Cystic liver disease (HP:0006706)2.95096226
24Polyuria (HP:0000103)2.93480067
25Aortic aneurysm (HP:0004942)2.91834170
26Polydipsia (HP:0001959)2.84715494
27Abnormal drinking behavior (HP:0030082)2.84715494
28Attenuation of retinal blood vessels (HP:0007843)2.83099274
29Shallow orbits (HP:0000586)2.77438999
30Gaze-evoked nystagmus (HP:0000640)2.71856958
31Sclerocornea (HP:0000647)2.70807940
32Gait imbalance (HP:0002141)2.70242771
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.66684368
34Vascular tortuosity (HP:0004948)2.65837232
35Spondylolisthesis (HP:0003302)2.64462168
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63906495
37Congenital hepatic fibrosis (HP:0002612)2.62601964
38Volvulus (HP:0002580)2.58763681
39Amelogenesis imperfecta (HP:0000705)2.57135471
40Congenital primary aphakia (HP:0007707)2.57105904
41Cutaneous melanoma (HP:0012056)2.57052506
42Soft skin (HP:0000977)2.53951247
43Arterial tortuosity (HP:0005116)2.49588588
44Type II lissencephaly (HP:0007260)2.48169054
45Oligodactyly (hands) (HP:0001180)2.47243164
46Short 4th metacarpal (HP:0010044)2.47125845
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47125845
48Neonatal short-limb short stature (HP:0008921)2.45064304
49Hypoplastic labia majora (HP:0000059)2.42953469
50Abnormal rod and cone electroretinograms (HP:0008323)2.41841032
51Decreased circulating renin level (HP:0003351)2.41704689
52Abnormal urine output (HP:0012590)2.40603579
53Short middle phalanx of the 5th finger (HP:0004220)2.38372497
54Nephrogenic diabetes insipidus (HP:0009806)2.38297961
55Osteolytic defects of the hand bones (HP:0009699)2.36326378
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.36326378
57Genital tract atresia (HP:0001827)2.32663269
58Cerebellar dysplasia (HP:0007033)2.31595100
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.31531358
60Absent frontal sinuses (HP:0002688)2.31157361
61Aplasia/Hypoplasia of the sternum (HP:0006714)2.30072497
62Anencephaly (HP:0002323)2.29747727
63Mesomelia (HP:0003027)2.28784484
64Poor coordination (HP:0002370)2.27876437
65Abnormality of renal excretion (HP:0011036)2.26910930
66Keratoconus (HP:0000563)2.26756699
67Increased corneal curvature (HP:0100692)2.26756699
68Postaxial foot polydactyly (HP:0001830)2.26336695
69Abnormal respiratory motile cilium physiology (HP:0012261)2.25768187
70Vaginal atresia (HP:0000148)2.25448457
71Subacute progressive viral hepatitis (HP:0006572)2.24365195
72Abnormality of the labia majora (HP:0012881)2.24274618
73Congenital sensorineural hearing impairment (HP:0008527)2.23949626
74Abolished electroretinogram (ERG) (HP:0000550)2.23677913
75Abnormality of dentin (HP:0010299)2.22385277
76Abnormal ciliary motility (HP:0012262)2.17087450
77Furrowed tongue (HP:0000221)2.16060381
78Bony spicule pigmentary retinopathy (HP:0007737)2.15085019
79Pendular nystagmus (HP:0012043)2.11798102
80Male pseudohermaphroditism (HP:0000037)2.08098614
81Rib fusion (HP:0000902)2.07849709
82Wormian bones (HP:0002645)2.07825198
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07553412
84Abnormality of alanine metabolism (HP:0010916)2.07553412
85Hyperalaninemia (HP:0003348)2.07553412
86Dilatation of the ascending aorta (HP:0005111)2.07511371
87Birth length less than 3rd percentile (HP:0003561)2.07005553
88Deep philtrum (HP:0002002)2.05695737
89Capillary hemangiomas (HP:0005306)2.04509633
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.03680502
91Absent/shortened dynein arms (HP:0200106)2.03680502
92Vertebral compression fractures (HP:0002953)2.00913899
93Fair hair (HP:0002286)2.00188159
94Protruding tongue (HP:0010808)1.99671443
95Abnormal biliary tract physiology (HP:0012439)1.99100254
96Bile duct proliferation (HP:0001408)1.99100254
97Optic nerve hypoplasia (HP:0000609)1.98584601
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98051295
99Asymmetry of the thorax (HP:0001555)1.97913299
100Flat capital femoral epiphysis (HP:0003370)1.97855166
101Occipital encephalocele (HP:0002085)1.97481846
102Small hand (HP:0200055)1.97233350
103Biconcave vertebral bodies (HP:0004586)1.95434985
104Hypoplasia of the fovea (HP:0007750)1.95256483
105Aplasia/Hypoplasia of the fovea (HP:0008060)1.95256483
106Mitral valve prolapse (HP:0001634)1.95141573
107Cerebral aneurysm (HP:0004944)1.94628905
108Decreased central vision (HP:0007663)1.93983690
109Long clavicles (HP:0000890)1.93928966
110Blue sclerae (HP:0000592)1.93196946
111Preaxial hand polydactyly (HP:0001177)1.92360841
112Abnormality of the acetabulum (HP:0003170)1.92074025
113Short 5th finger (HP:0009237)1.90651427
114Nephroblastoma (Wilms tumor) (HP:0002667)1.90440646
115Anophthalmia (HP:0000528)1.90048731
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.89890791
117Broad palm (HP:0001169)1.89013118
118Postaxial hand polydactyly (HP:0001162)1.88966406
119Enlarged kidneys (HP:0000105)1.88456584
120Embryonal renal neoplasm (HP:0011794)1.87945224
121Aganglionic megacolon (HP:0002251)1.87728225
122Abnormality of the renal collecting system (HP:0004742)1.87149940
123Ectopic kidney (HP:0000086)1.86767323
124Severe visual impairment (HP:0001141)1.86394934
125Camptodactyly of toe (HP:0001836)1.86148223
126Chorioretinal atrophy (HP:0000533)1.85553573
127Deviation of the thumb (HP:0009603)1.85040623
128Wrist flexion contracture (HP:0001239)1.84912219
129Abnormality of the ischium (HP:0003174)1.84656353
130Abnormal respiratory epithelium morphology (HP:0012253)1.84432199
131Abnormal respiratory motile cilium morphology (HP:0005938)1.84432199
132Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.84142972
133Acute myeloid leukemia (HP:0004808)1.83772621
134Cupped ribs (HP:0000887)1.83121101
135Thyroid-stimulating hormone excess (HP:0002925)1.82794474
136Hypoplastic iliac wings (HP:0002866)1.82635933
137Inability to walk (HP:0002540)1.82616699
138Abnormality of the nasal septum (HP:0000419)1.81727231
139Papillary thyroid carcinoma (HP:0002895)1.81368708
140Decreased skull ossification (HP:0004331)1.80804547
141Astigmatism (HP:0000483)1.80551709
142Highly arched eyebrow (HP:0002553)1.80186732
143Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80173076
144Rhinitis (HP:0012384)1.80026169
145Retinitis pigmentosa (HP:0000510)1.79994591
146Absent speech (HP:0001344)1.79538884
147Broad long bones (HP:0005622)1.79440569
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78608895
149Atrophic scars (HP:0001075)1.78553239
150High pitched voice (HP:0001620)1.77098202
151Intestinal atresia (HP:0011100)1.77014995
152Drooling (HP:0002307)1.76874516
153Abnormality of the aortic arch (HP:0012303)1.76622262
154Tachypnea (HP:0002789)1.76343147
155Congenital, generalized hypertrichosis (HP:0004540)1.76216889
156Abnormality of the pons (HP:0007361)1.75681192
157Microglossia (HP:0000171)1.75469085
158Facial hemangioma (HP:0000329)1.74812893
159Aplasia/Hypoplasia of the uvula (HP:0010293)1.73857275
160Prominent nasal bridge (HP:0000426)1.72945026
161Follicular hyperkeratosis (HP:0007502)1.72679315
162Abnormality of the proximal phalanges of the hand (HP:0009834)1.71786524
163Hematochezia (HP:0002573)1.71638232
164Broad thumb (HP:0011304)1.71633289
165Broad phalanx (HP:0006009)1.71252445
166Selective tooth agenesis (HP:0001592)1.68924175
167Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.68287077
168Abnormality of the calcaneus (HP:0008364)1.67650685
169Elbow flexion contracture (HP:0002987)1.67062195
170Dislocated radial head (HP:0003083)1.66876516
171Patellar aplasia (HP:0006443)1.66212877
172Abnormality of incisor morphology (HP:0011063)1.66030536
173Cortical dysplasia (HP:0002539)1.64671023
174Abnormality of the anterior horn cell (HP:0006802)1.64360875
175Degeneration of anterior horn cells (HP:0002398)1.64360875
176Breast hypoplasia (HP:0003187)1.63968142
177Lip pit (HP:0100267)1.62777456
178Abnormality of the phalanges of the 5th finger (HP:0004213)1.61675373
179Abnormality of skull ossification (HP:0002703)1.60585884
180Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.60156387
181Broad phalanges of the hand (HP:0009768)1.60109786
182Exostoses (HP:0100777)1.58885695
183Prostate neoplasm (HP:0100787)1.58842437
184Increased number of teeth (HP:0011069)1.58450554
185Adrenal hypoplasia (HP:0000835)1.56923011
186Flared metaphyses (HP:0003015)1.56863233
18711 pairs of ribs (HP:0000878)1.55362947
188Abnormality of the radial head (HP:0003995)1.55293647
189Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.54941497
190Vertebral hypoplasia (HP:0008417)1.54941497
191Aortic regurgitation (HP:0001659)1.54924734
192Abnormality of the 4th metacarpal (HP:0010012)1.54799461
193Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.54286965
194Spinal rigidity (HP:0003306)1.53957699
195Slender long bone (HP:0003100)1.53700774
196Proximal placement of thumb (HP:0009623)1.53457123
197Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.53197987
198Short nail (HP:0001799)1.52765677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.16211316
2LATS13.15124024
3ADRBK22.71035055
4NEK92.56545288
5MKNK12.45712832
6EIF2AK12.42891898
7DDR22.42233504
8CASK2.28455224
9WNK42.27218437
10NTRK22.23442267
11RPS6KA42.22424481
12GRK12.22220186
13MAP4K22.20631300
14WNK32.13068839
15TGFBR12.09593994
16NUAK12.03130161
17TNIK2.02801178
18INSRR1.99974627
19STK391.98250808
20STK101.96893910
21OXSR11.92730826
22TTK1.90034993
23ACVR1B1.89357991
24STK38L1.88825252
25BRSK21.85255479
26* STK31.81566814
27PLK31.78875184
28PINK11.72005432
29PLK41.61080613
30TRPM71.60304380
31ERBB31.58576413
32CDK81.57483077
33SRPK11.47511709
34ZAK1.42286060
35FRK1.42160709
36EPHB21.41939400
37MAPK131.40623296
38NEK21.38723356
39TGFBR21.36244616
40TRIM281.32877231
41WEE11.32717517
42EPHA31.29589765
43CDK121.29418273
44PLK11.28895316
45RIPK11.28795961
46AURKB1.27565729
47ADRBK11.26346345
48MELK1.24949449
49LATS21.22466364
50MAP3K41.19601170
51PAK41.19385840
52CHUK1.17416368
53CDK61.16444492
54MAP3K81.15943352
55MKNK21.11586697
56ATR1.11563868
57NEK11.09148278
58PLK21.09076429
59TLK11.08021896
60CHEK21.07557651
61KIT1.06699386
62PDGFRA1.06560386
63EIF2AK21.02405727
64STK41.01678883
65PNCK1.01482269
66PRKCE0.98480916
67AKT30.97839303
68DMPK0.97581750
69CDK70.96931978
70FLT30.93606366
71MUSK0.92726330
72TIE10.92319962
73DYRK30.91164543
74PIK3CA0.90956034
75TTN0.90917999
76JAK30.87638381
77LRRK20.86266032
78NTRK30.85285762
79MAP3K60.85248212
80BUB10.85214314
81FER0.84937017
82PIM10.84623557
83TAOK30.81766545
84DAPK20.81697322
85STK240.81462973
86ATM0.80349989
87EIF2AK30.78265098
88PRKCG0.78042564
89PASK0.77348458
90PTK2B0.76005440
91MST40.75232132
92YES10.73171882
93MAP3K100.72227505
94RPS6KB20.72082351
95GRK70.71653423
96EPHA20.70570862
97ILK0.68570549
98MAP2K70.68326569
99OBSCN0.68154840
100PBK0.67887873
101PDK20.67856361
102CSNK1A10.67164269
103CDK90.66810592
104PRKCQ0.66572706
105CDK40.66427418
106BMPR1B0.65343938
107MOS0.64872902
108BCR0.64824924
109PAK20.64426221
110PHKG10.64081421
111PHKG20.64081421
112TEC0.62185002
113PTK60.61760529
114MAP2K30.59705080
115CHEK10.59328233
116TNK20.58193529
117RPS6KA50.57944209
118TAOK20.57190488
119PTK20.57039655
120MET0.55354358
121BMX0.55247285
122STK110.53141597
123CDK190.52881400
124MAP3K30.51875807
125VRK10.51793585
126DYRK20.51550559
127PKN10.50997569
128PRKAA20.50996038
129CAMK2A0.50358723
130SGK10.50350735
131CAMK1G0.50242626
132FGFR20.50149626
133ERBB40.50007044
134MARK30.49720686
135SGK20.48572725
136PAK30.47941052
137IRAK10.47817589
138KSR10.47680694
139CAMKK20.47512221
140CAMK1D0.47204594
141CAMK10.45386829
142SCYL20.44014703
143MAP3K50.43734637
144MAP3K140.43456460
145FGFR30.43446847
146IKBKB0.42893515
147* PRKACA0.41523857
148PIK3CG0.41426278
149RAF10.41001338
150PRKCI0.40403557
151CCNB10.39730109
152PKN20.38864343
153TXK0.38487445
154PRKAA10.38404700
155MAP3K120.38296232
156EPHA40.37408309
157MAP3K70.36231504
158CSNK1G10.35205472
159CAMK40.33652444
160MYLK0.32226177
161CSNK1A1L0.32144932
162MARK10.31245498
163PRKACB0.30758409
164FGFR10.30676595
165* PRKCA0.30607881
166MAP2K60.30507629
167ERBB20.30331800

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.09116746
2Linoleic acid metabolism_Homo sapiens_hsa005912.75917903
3Olfactory transduction_Homo sapiens_hsa047402.59288592
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.53988080
5Phototransduction_Homo sapiens_hsa047442.50200992
6DNA replication_Homo sapiens_hsa030302.47273463
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36110740
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.32951979
9Mismatch repair_Homo sapiens_hsa034302.26451816
10Tryptophan metabolism_Homo sapiens_hsa003802.15486994
11Butanoate metabolism_Homo sapiens_hsa006502.12811747
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.09114492
13Homologous recombination_Homo sapiens_hsa034401.99030698
14ECM-receptor interaction_Homo sapiens_hsa045121.98090131
15p53 signaling pathway_Homo sapiens_hsa041151.97711278
16TGF-beta signaling pathway_Homo sapiens_hsa043501.96934987
17Base excision repair_Homo sapiens_hsa034101.91418005
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89253895
19Adherens junction_Homo sapiens_hsa045201.88583884
20Nucleotide excision repair_Homo sapiens_hsa034201.85446580
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83955100
22RNA degradation_Homo sapiens_hsa030181.82155279
23RNA transport_Homo sapiens_hsa030131.81285259
24Non-homologous end-joining_Homo sapiens_hsa034501.81024116
25Malaria_Homo sapiens_hsa051441.79828458
26Caffeine metabolism_Homo sapiens_hsa002321.79301097
27Small cell lung cancer_Homo sapiens_hsa052221.77213539
28Nitrogen metabolism_Homo sapiens_hsa009101.76384836
29MicroRNAs in cancer_Homo sapiens_hsa052061.76154844
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.74834947
31Ether lipid metabolism_Homo sapiens_hsa005651.68899041
32Propanoate metabolism_Homo sapiens_hsa006401.68165235
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68134200
34Selenocompound metabolism_Homo sapiens_hsa004501.61576058
35Focal adhesion_Homo sapiens_hsa045101.59532297
36Proteoglycans in cancer_Homo sapiens_hsa052051.55664413
37Morphine addiction_Homo sapiens_hsa050321.54001561
38* Hippo signaling pathway_Homo sapiens_hsa043901.52375150
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52046417
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.51928032
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49116097
42Taste transduction_Homo sapiens_hsa047421.47119012
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.45623994
44Viral carcinogenesis_Homo sapiens_hsa052031.45336044
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.44585171
46ABC transporters_Homo sapiens_hsa020101.43490795
47Pancreatic cancer_Homo sapiens_hsa052121.40723411
48Chemical carcinogenesis_Homo sapiens_hsa052041.40575309
49Retinol metabolism_Homo sapiens_hsa008301.39227011
50HTLV-I infection_Homo sapiens_hsa051661.37695618
51Leishmaniasis_Homo sapiens_hsa051401.33365229
52Insulin secretion_Homo sapiens_hsa049111.33074384
53Spliceosome_Homo sapiens_hsa030401.33036941
54Chronic myeloid leukemia_Homo sapiens_hsa052201.31954975
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30373561
56Herpes simplex infection_Homo sapiens_hsa051681.30336429
57Fanconi anemia pathway_Homo sapiens_hsa034601.29315148
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29064805
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28259675
60Circadian entrainment_Homo sapiens_hsa047131.25622312
61Systemic lupus erythematosus_Homo sapiens_hsa053221.23530064
62Basal cell carcinoma_Homo sapiens_hsa052171.23278527
63Glutamatergic synapse_Homo sapiens_hsa047241.23170817
64Viral myocarditis_Homo sapiens_hsa054161.22535812
65Legionellosis_Homo sapiens_hsa051341.21787250
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21043766
67Prostate cancer_Homo sapiens_hsa052151.20344744
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20018569
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.19474362
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19226068
71Hepatitis B_Homo sapiens_hsa051611.18719571
72Nicotine addiction_Homo sapiens_hsa050331.17486212
73Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15140897
74Serotonergic synapse_Homo sapiens_hsa047261.14914920
75Salivary secretion_Homo sapiens_hsa049701.14368767
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12704220
77Basal transcription factors_Homo sapiens_hsa030221.12216246
78Arachidonic acid metabolism_Homo sapiens_hsa005901.11504013
79Colorectal cancer_Homo sapiens_hsa052101.11210283
80Dorso-ventral axis formation_Homo sapiens_hsa043201.10759441
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10448699
82Oxidative phosphorylation_Homo sapiens_hsa001901.09534131
83GABAergic synapse_Homo sapiens_hsa047271.09467521
84mRNA surveillance pathway_Homo sapiens_hsa030151.08211443
85Sulfur metabolism_Homo sapiens_hsa009201.05831295
86Shigellosis_Homo sapiens_hsa051311.05072679
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02216169
88Toxoplasmosis_Homo sapiens_hsa051451.01674123
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01540641
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00545706
91Thyroid cancer_Homo sapiens_hsa052160.99892378
92Sulfur relay system_Homo sapiens_hsa041220.99598847
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.99416101
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.99327452
95TNF signaling pathway_Homo sapiens_hsa046680.98957079
96Apoptosis_Homo sapiens_hsa042100.96953404
97Measles_Homo sapiens_hsa051620.96320506
98Pathways in cancer_Homo sapiens_hsa052000.96086649
99Protein export_Homo sapiens_hsa030600.93391246
100Glycerolipid metabolism_Homo sapiens_hsa005610.91286116
101Hedgehog signaling pathway_Homo sapiens_hsa043400.90704590
102Bladder cancer_Homo sapiens_hsa052190.89531939
103Notch signaling pathway_Homo sapiens_hsa043300.88439091
104Epstein-Barr virus infection_Homo sapiens_hsa051690.88201306
105Calcium signaling pathway_Homo sapiens_hsa040200.87211437
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86939060
107Antigen processing and presentation_Homo sapiens_hsa046120.86936707
108Melanoma_Homo sapiens_hsa052180.86910616
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.86714593
110Influenza A_Homo sapiens_hsa051640.86694376
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.86063341
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85945438
113Fatty acid biosynthesis_Homo sapiens_hsa000610.85779947
114Peroxisome_Homo sapiens_hsa041460.85751217
115Fatty acid degradation_Homo sapiens_hsa000710.85458209
116One carbon pool by folate_Homo sapiens_hsa006700.84875909
117Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83794059
118Oocyte meiosis_Homo sapiens_hsa041140.83179894
119Fat digestion and absorption_Homo sapiens_hsa049750.82442689
120Amoebiasis_Homo sapiens_hsa051460.81187412
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78156412
122Histidine metabolism_Homo sapiens_hsa003400.77526670
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77352024
124Gastric acid secretion_Homo sapiens_hsa049710.77039297
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76297984
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.75915049
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75829378
128Collecting duct acid secretion_Homo sapiens_hsa049660.75234398
129HIF-1 signaling pathway_Homo sapiens_hsa040660.71436735
130Platelet activation_Homo sapiens_hsa046110.70695473
131Huntingtons disease_Homo sapiens_hsa050160.69599922
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68748623
133Parkinsons disease_Homo sapiens_hsa050120.68410678
134Pancreatic secretion_Homo sapiens_hsa049720.68094115
135Endometrial cancer_Homo sapiens_hsa052130.67111122
136Circadian rhythm_Homo sapiens_hsa047100.66534552
137Purine metabolism_Homo sapiens_hsa002300.66187295
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64928964
139RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64454979
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63763505
141beta-Alanine metabolism_Homo sapiens_hsa004100.63721160
142Oxytocin signaling pathway_Homo sapiens_hsa049210.63521242
143Ovarian steroidogenesis_Homo sapiens_hsa049130.62832865
144FoxO signaling pathway_Homo sapiens_hsa040680.62567161
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.62387220
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62322572
147Wnt signaling pathway_Homo sapiens_hsa043100.62037487
148Protein digestion and absorption_Homo sapiens_hsa049740.61482362
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.60285994
150NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59865527
151Steroid biosynthesis_Homo sapiens_hsa001000.59710778
152Renal cell carcinoma_Homo sapiens_hsa052110.59150714
153Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58956508
154Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.58836348
155Bile secretion_Homo sapiens_hsa049760.58638739
156Osteoclast differentiation_Homo sapiens_hsa043800.57805124
157Cholinergic synapse_Homo sapiens_hsa047250.57765159
158Salmonella infection_Homo sapiens_hsa051320.57722888
159Lysine degradation_Homo sapiens_hsa003100.56966849
160Cardiac muscle contraction_Homo sapiens_hsa042600.56332505
161Pyrimidine metabolism_Homo sapiens_hsa002400.55829028
162Sphingolipid metabolism_Homo sapiens_hsa006000.55355532
163Glycerophospholipid metabolism_Homo sapiens_hsa005640.55111122
164Hematopoietic cell lineage_Homo sapiens_hsa046400.54775388
165Tight junction_Homo sapiens_hsa045300.54552029
166RNA polymerase_Homo sapiens_hsa030200.54415204
167Metabolic pathways_Homo sapiens_hsa011000.54137682
168Intestinal immune network for IgA production_Homo sapiens_hsa046720.53092598
169Regulation of autophagy_Homo sapiens_hsa041400.52198495
170Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50987826
171Dilated cardiomyopathy_Homo sapiens_hsa054140.50769575
172Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49900575
173Allograft rejection_Homo sapiens_hsa053300.49457881
174Prolactin signaling pathway_Homo sapiens_hsa049170.49109349
175Dopaminergic synapse_Homo sapiens_hsa047280.47413299
176Phagosome_Homo sapiens_hsa041450.46433248
177Central carbon metabolism in cancer_Homo sapiens_hsa052300.46159817
178Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45191518
179Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44315688
180Aldosterone synthesis and secretion_Homo sapiens_hsa049250.43449307
181Long-term depression_Homo sapiens_hsa047300.43422566
182cAMP signaling pathway_Homo sapiens_hsa040240.42246492
183Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40461994
184Cocaine addiction_Homo sapiens_hsa050300.39664721
185Thyroid hormone synthesis_Homo sapiens_hsa049180.39224868
186Alzheimers disease_Homo sapiens_hsa050100.37719350
187Fatty acid metabolism_Homo sapiens_hsa012120.37588910

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