STK31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is similar to a mouse gene that encodes a putative protein kinase with a tudor domain, and shows testis-specific expression. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptonemal complex assembly (GO:0007130)9.33716125
2male meiosis (GO:0007140)9.17223525
3synaptonemal complex organization (GO:0070193)8.97444185
4regulation of meiosis I (GO:0060631)8.04955378
5meiotic nuclear division (GO:0007126)7.15620175
6chromosome organization involved in meiosis (GO:0070192)6.94609083
7male meiosis I (GO:0007141)6.85079231
8meiosis I (GO:0007127)5.90654469
9gene silencing by RNA (GO:0031047)5.79126793
10cilium or flagellum-dependent cell motility (GO:0001539)5.50903709
11DNA methylation (GO:0006306)5.24134969
12DNA alkylation (GO:0006305)5.24134969
13meiotic cell cycle process (GO:1903046)5.15838413
14nuclear pore complex assembly (GO:0051292)4.89780930
15nuclear pore organization (GO:0006999)4.85416844
16fusion of sperm to egg plasma membrane (GO:0007342)4.83678217
17meiotic chromosome segregation (GO:0045132)4.75164721
18oogenesis (GO:0048477)4.57109320
19attachment of spindle microtubules to kinetochore (GO:0008608)4.53417073
20binding of sperm to zona pellucida (GO:0007339)4.44504399
21reciprocal DNA recombination (GO:0035825)4.43396498
22reciprocal meiotic recombination (GO:0007131)4.43396498
23meiotic cell cycle (GO:0051321)4.41078238
24sister chromatid cohesion (GO:0007062)4.36815710
25negative regulation of meiosis (GO:0045835)4.34762276
26sperm-egg recognition (GO:0035036)4.27841105
27spermatid development (GO:0007286)4.23691332
28synapsis (GO:0007129)4.16438967
29gene silencing (GO:0016458)4.13173390
30DNA methylation or demethylation (GO:0044728)4.12630605
31mitotic chromosome condensation (GO:0007076)4.03446988
32regulation of DNA endoreduplication (GO:0032875)3.98514683
33female gamete generation (GO:0007292)3.88724826
34positive regulation of meiosis (GO:0045836)3.85111101
35germ cell development (GO:0007281)3.83856526
36DNA replication-dependent nucleosome organization (GO:0034723)3.82122338
37DNA replication-dependent nucleosome assembly (GO:0006335)3.82122338
38resolution of meiotic recombination intermediates (GO:0000712)3.79152306
39cell-cell recognition (GO:0009988)3.78376037
40protein K6-linked ubiquitination (GO:0085020)3.77366267
41mitotic metaphase plate congression (GO:0007080)3.75476546
42sperm motility (GO:0030317)3.73184996
43histone H3-K9 demethylation (GO:0033169)3.72724835
44kinetochore organization (GO:0051383)3.70963753
45DNA synthesis involved in DNA repair (GO:0000731)3.70425975
46histone exchange (GO:0043486)3.70103965
47positive regulation of meiotic cell cycle (GO:0051446)3.68899383
48heterochromatin organization (GO:0070828)3.68192495
49pore complex assembly (GO:0046931)3.67209982
50axonemal dynein complex assembly (GO:0070286)3.66234720
51metaphase plate congression (GO:0051310)3.63684373
52regulation of centriole replication (GO:0046599)3.63045974
53multicellular organism reproduction (GO:0032504)3.62324084
54regulation of histone H3-K9 methylation (GO:0051570)3.56816684
55DNA replication checkpoint (GO:0000076)3.56292970
56negative regulation of gene silencing (GO:0060969)3.55442086
57plasma membrane fusion (GO:0045026)3.53452030
58regulation of chromosome segregation (GO:0051983)3.51852398
59DNA modification (GO:0006304)3.49713783
60male gamete generation (GO:0048232)3.47721774
61spermatogenesis (GO:0007283)3.47382751
62mitotic sister chromatid cohesion (GO:0007064)3.46355563
63acrosome assembly (GO:0001675)3.46292039
64microtubule depolymerization (GO:0007019)3.44575982
65regulation of meiotic cell cycle (GO:0051445)3.41685878
66oocyte maturation (GO:0001556)3.39854811
67negative regulation of chromosome segregation (GO:0051985)3.39053535
68chromatin remodeling at centromere (GO:0031055)3.37954649
69kinetochore assembly (GO:0051382)3.37532857
70mitotic nuclear envelope disassembly (GO:0007077)3.37475651
71axoneme assembly (GO:0035082)3.34813810
72monoubiquitinated protein deubiquitination (GO:0035520)3.34502095
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.33959886
74negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33959886
75negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33959886
76negative regulation of sister chromatid segregation (GO:0033046)3.33959886
77regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.33002920
78mitotic spindle assembly checkpoint (GO:0007094)3.32654017
79gamete generation (GO:0007276)3.30938624
80regulation of female receptivity (GO:0045924)3.29965619
81spindle assembly checkpoint (GO:0071173)3.29590749
82mitotic spindle checkpoint (GO:0071174)3.28900684
83regulation of meiosis (GO:0040020)3.28714980
84epithelial cilium movement (GO:0003351)3.28393503
85negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.28354806
86chromosome organization (GO:0051276)3.25738630
87regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24890334
88spindle checkpoint (GO:0031577)3.23930772
89protein localization to chromosome, centromeric region (GO:0071459)3.22327734
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.20765261
91mitotic sister chromatid segregation (GO:0000070)3.20740677
92regulation of double-strand break repair via homologous recombination (GO:0010569)3.20709314
93cellular process involved in reproduction in multicellular organism (GO:0022412)3.20201846
94protein localization to kinetochore (GO:0034501)3.19889518
95positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.19746975
96sex differentiation (GO:0007548)3.19228793
97membrane disassembly (GO:0030397)3.19105584
98nuclear envelope disassembly (GO:0051081)3.19105584
99regulation of sister chromatid segregation (GO:0033045)3.18065636
100regulation of mitotic sister chromatid separation (GO:0010965)3.18065636
101regulation of mitotic sister chromatid segregation (GO:0033047)3.18065636
102oocyte development (GO:0048599)3.13555778
103regulation of centrosome cycle (GO:0046605)3.13425725
104fertilization (GO:0009566)3.12898393
105positive regulation of translational initiation (GO:0045948)3.10490919
106histone H3-K36 demethylation (GO:0070544)3.10107517
107regulation of cilium movement (GO:0003352)3.04181919
108photoreceptor cell maintenance (GO:0045494)2.99013949
109histone H4-K12 acetylation (GO:0043983)2.96188593
110behavioral response to nicotine (GO:0035095)2.93560223
111proteasome assembly (GO:0043248)2.92241203
112regulation of microtubule-based movement (GO:0060632)2.87984158
113detection of light stimulus involved in visual perception (GO:0050908)2.87573399
114detection of light stimulus involved in sensory perception (GO:0050962)2.87573399
115protein polyglutamylation (GO:0018095)2.85800270
116interkinetic nuclear migration (GO:0022027)2.82310553
117reproductive system development (GO:0061458)2.81724797
118genitalia morphogenesis (GO:0035112)2.78954670
119protein K11-linked deubiquitination (GO:0035871)2.78757961
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76086188
121female mating behavior (GO:0060180)2.74410189
122centriole replication (GO:0007099)2.72250720
123indolalkylamine metabolic process (GO:0006586)2.71590406
124transmission of nerve impulse (GO:0019226)2.67215042
125indole-containing compound catabolic process (GO:0042436)2.65612715
126indolalkylamine catabolic process (GO:0046218)2.65612715
127tryptophan catabolic process (GO:0006569)2.65612715
128histone H2A acetylation (GO:0043968)2.64275933
129negative regulation of DNA-dependent DNA replication (GO:2000104)2.61499822
130regulation of collateral sprouting (GO:0048670)2.61356084
131acrosome reaction (GO:0007340)2.59343578
132negative regulation of appetite (GO:0032099)2.56521168
133negative regulation of response to food (GO:0032096)2.56521168
134centriole assembly (GO:0098534)2.53552270
135positive regulation of cellular response to oxidative stress (GO:1900409)2.53039170
136positive regulation of response to oxidative stress (GO:1902884)2.53039170
137retinal cone cell development (GO:0046549)2.52493449
138intraciliary transport (GO:0042073)2.50704574
139sulfation (GO:0051923)2.46258063
140epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.44451568
141regulation of transcription from RNA polymerase I promoter (GO:0006356)2.44357094
142negative regulation of inclusion body assembly (GO:0090084)2.41338294
143negative regulation of mast cell activation (GO:0033004)2.34792018
144kynurenine metabolic process (GO:0070189)2.31865632
145response to pheromone (GO:0019236)2.28205016
146DNA biosynthetic process (GO:0071897)2.27976633
147tryptophan metabolic process (GO:0006568)2.27928042
148establishment of protein localization to Golgi (GO:0072600)2.27409401
149protein localization to chromosome (GO:0034502)2.24438907
150adaptation of signaling pathway (GO:0023058)2.22677859
151cilium morphogenesis (GO:0060271)2.22151583
152piRNA metabolic process (GO:0034587)13.5192497
153DNA methylation involved in gamete generation (GO:0043046)10.6569564

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.19980089
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.62294703
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.46290164
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.67139069
5IGF1R_20145208_ChIP-Seq_DFB_Human3.66922958
6ZNF274_21170338_ChIP-Seq_K562_Hela3.45139337
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27531716
8EZH2_22144423_ChIP-Seq_EOC_Human3.06692435
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.99677246
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.98965879
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.87088342
12VDR_22108803_ChIP-Seq_LS180_Human2.81372376
13AR_21909140_ChIP-Seq_LNCAP_Human2.74535267
14GBX2_23144817_ChIP-Seq_PC3_Human2.57532002
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.57418797
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.41370812
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36232314
18FUS_26573619_Chip-Seq_HEK293_Human2.30415737
19* MYCN_18555785_ChIP-Seq_MESCs_Mouse2.28701253
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.27155698
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25684170
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25226593
23* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.24756303
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.23804100
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.23804100
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.23804100
27* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15769275
28MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12269866
29ER_23166858_ChIP-Seq_MCF-7_Human2.10256195
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.09856268
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07226754
32TAF15_26573619_Chip-Seq_HEK293_Human2.04494358
33CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04105067
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03147233
35CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01404113
36NELFA_20434984_ChIP-Seq_ESCs_Mouse2.01178805
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97555260
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96146811
39EWS_26573619_Chip-Seq_HEK293_Human1.95774288
40BCAT_22108803_ChIP-Seq_LS180_Human1.92308712
41P300_19829295_ChIP-Seq_ESCs_Human1.91860044
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.91847072
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90015576
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89519713
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.84689031
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83977908
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82455299
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.81741899
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.79667704
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77406248
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72478901
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.71639999
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71175252
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68017591
55CBP_20019798_ChIP-Seq_JUKART_Human1.68017591
56TP53_22573176_ChIP-Seq_HFKS_Human1.68001135
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66072249
58SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65313170
59STAT3_23295773_ChIP-Seq_U87_Human1.63979962
60TCF4_23295773_ChIP-Seq_U87_Human1.58589997
61AR_25329375_ChIP-Seq_VCAP_Human1.56501137
62VDR_23849224_ChIP-Seq_CD4+_Human1.52422694
63SMAD4_21799915_ChIP-Seq_A2780_Human1.52274902
64XRN2_22483619_ChIP-Seq_HELA_Human1.51994303
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51601656
66* RUNX2_22187159_ChIP-Seq_PCA_Human1.51046940
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.47837244
68KDM5A_27292631_Chip-Seq_BREAST_Human1.46280080
69DCP1A_22483619_ChIP-Seq_HELA_Human1.45967865
70* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45116466
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44167591
72GABP_19822575_ChIP-Seq_HepG2_Human1.43545074
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.43149256
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43100329
75SMAD4_21741376_ChIP-Seq_EPCs_Human1.41632222
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41431085
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38238094
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36512497
79* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35243482
80PRDM14_20953172_ChIP-Seq_ESCs_Human1.33445852
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.32284717
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32284717
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31713529
84* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31249162
85NOTCH1_21737748_ChIP-Seq_TLL_Human1.31144117
86NCOR_22424771_ChIP-Seq_293T_Human1.29011709
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28216850
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27864989
89HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27741739
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.27716771
91FOXP3_21729870_ChIP-Seq_TREG_Human1.26672295
92* GATA1_26923725_Chip-Seq_HPCs_Mouse1.26329140
93HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26056232
94TCF4_22108803_ChIP-Seq_LS180_Human1.25977821
95NANOG_19829295_ChIP-Seq_ESCs_Human1.25520370
96SOX2_19829295_ChIP-Seq_ESCs_Human1.25520370
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24709953
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24662766
99AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24497864
100* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.23477060
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20252126
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.19671210
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17961052
104TTF2_22483619_ChIP-Seq_HELA_Human1.17670689
105YY1_21170310_ChIP-Seq_MESCs_Mouse1.17060569
106AR_20517297_ChIP-Seq_VCAP_Human1.17060066
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.16756443
108* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16436936
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15336140
110TAL1_26923725_Chip-Seq_HPCs_Mouse1.15085269
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14925355
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14451504
113E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13149453
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12797334
115NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12730022
116FLI1_27457419_Chip-Seq_LIVER_Mouse1.12359017
117* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10189429
118TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09852906
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09852906
120* HOXB7_26014856_ChIP-Seq_BT474_Human1.09427570
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.08950516
122SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08637480
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.08176596
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07980060
125FOXH1_21741376_ChIP-Seq_EPCs_Human1.07862657
126TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06795593
127SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06251687
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05633659
129IRF1_19129219_ChIP-ChIP_H3396_Human1.05217648
130FLI1_21867929_ChIP-Seq_TH2_Mouse1.04474715
131CDX2_22108803_ChIP-Seq_LS180_Human1.02771109
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.01235633
133REST_21632747_ChIP-Seq_MESCs_Mouse0.99926157
134MYC_19829295_ChIP-Seq_ESCs_Human0.99620671
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99374265
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99355379
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99135818
138ERA_21632823_ChIP-Seq_H3396_Human0.98498372
139PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97916737
140ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97070682
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.96504472
142PIAS1_25552417_ChIP-Seq_VCAP_Human0.96265187
143SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96066398
144HTT_18923047_ChIP-ChIP_STHdh_Human0.95935527
145STAT3_18555785_Chip-Seq_ESCs_Mouse0.95808114
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95214411
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95034155
148NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.94154732
149CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93001848
150TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90700297
151DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90590828
152HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88154709
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87786692
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87059045
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86951836
156MYC_18940864_ChIP-ChIP_HL60_Human0.86898705
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86796595
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86479814
159NANOG_21062744_ChIP-ChIP_HESCs_Human0.85267463
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85029761
161NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.85023165
162* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.84588010
163* RNF2_27304074_Chip-Seq_NSC_Mouse0.83535447
164ELK4_26923725_Chip-Seq_MESODERM_Mouse0.82141687
165CIITA_25753668_ChIP-Seq_RAJI_Human0.81826562
166TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81029898
167TFEB_21752829_ChIP-Seq_HELA_Human0.79864428
168FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77005235
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76396849
170* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.74921392
171CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.74805245
172STAT6_21828071_ChIP-Seq_BEAS2B_Human0.72207132
173POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68015173
174ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.67044783
175ELK1_19687146_ChIP-ChIP_HELA_Human0.66046307
176GATA3_21867929_ChIP-Seq_TH1_Mouse0.65916972
177* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.65584899
178ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.65186800
179* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.64239345
180POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.63589883
181SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.61482990
182NFE2_27457419_Chip-Seq_LIVER_Mouse0.60942292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation9.30454327
2MP0010094_abnormal_chromosome_stability4.36525004
3MP0002210_abnormal_sex_determination4.27223198
4MP0005410_abnormal_fertilization4.14504631
5MP0001929_abnormal_gametogenesis4.11956481
6MP0008057_abnormal_DNA_replication4.00819153
7MP0008995_early_reproductive_senescence3.97692954
8MP0008058_abnormal_DNA_repair3.54981164
9MP0003693_abnormal_embryo_hatching3.49305393
10MP0001145_abnormal_male_reproductive3.46870147
11MP0003698_abnormal_male_reproductive3.46176092
12MP0003111_abnormal_nucleus_morphology3.45472980
13MP0003786_premature_aging3.29240060
14MP0000653_abnormal_sex_gland3.16072483
15MP0004957_abnormal_blastocyst_morpholog3.03848171
16MP0003077_abnormal_cell_cycle2.90166910
17MP0003123_paternal_imprinting2.45159163
18MP0000383_abnormal_hair_follicle2.21409552
19MP0008007_abnormal_cellular_replicative2.14529819
20MP0002161_abnormal_fertility/fecundity2.14476328
21MP0005646_abnormal_pituitary_gland2.12922846
22MP0001730_embryonic_growth_arrest1.95907256
23MP0002653_abnormal_ependyma_morphology1.95284606
24MP0003718_maternal_effect1.93630109
25MP0002837_dystrophic_cardiac_calcinosis1.93179999
26MP0008932_abnormal_embryonic_tissue1.86838608
27MP0005551_abnormal_eye_electrophysiolog1.81942346
28MP0001968_abnormal_touch/_nociception1.65933269
29MP0001119_abnormal_female_reproductive1.64424644
30MP0000350_abnormal_cell_proliferation1.56856978
31MP0002160_abnormal_reproductive_system1.54945036
32MP0002736_abnormal_nociception_after1.54112856
33MP0010307_abnormal_tumor_latency1.53449092
34MP0010678_abnormal_skin_adnexa1.48473230
35MP0000631_abnormal_neuroendocrine_gland1.42767599
36MP0005174_abnormal_tail_pigmentation1.42526129
37MP0003880_abnormal_central_pattern1.36726847
38MP0003121_genomic_imprinting1.36571679
39MP0003195_calcinosis1.35326639
40MP0001672_abnormal_embryogenesis/_devel1.33995649
41MP0005380_embryogenesis_phenotype1.33995649
42MP0002876_abnormal_thyroid_physiology1.33556307
43MP0001984_abnormal_olfaction1.32950709
44MP0003890_abnormal_embryonic-extraembry1.32732259
45MP0003699_abnormal_female_reproductive1.28930801
46MP0001697_abnormal_embryo_size1.28011272
47MP0002085_abnormal_embryonic_tissue1.27604056
48MP0002084_abnormal_developmental_patter1.27212737
49MP0004885_abnormal_endolymph1.25101666
50MP0000015_abnormal_ear_pigmentation1.23506765
51MP0002138_abnormal_hepatobiliary_system1.23034132
52MP0010352_gastrointestinal_tract_polyps1.20257278
53MP0000372_irregular_coat_pigmentation1.17673520
54MP0006276_abnormal_autonomic_nervous1.17619152
55MP0008789_abnormal_olfactory_epithelium1.15087562
56MP0002095_abnormal_skin_pigmentation1.15055357
57MP0003984_embryonic_growth_retardation1.14875681
58MP0003646_muscle_fatigue1.14468311
59MP0001486_abnormal_startle_reflex1.12401325
60MP0001485_abnormal_pinna_reflex1.12044935
61MP0002272_abnormal_nervous_system1.11872875
62MP0005253_abnormal_eye_physiology1.10302186
63MP0002088_abnormal_embryonic_growth/wei1.09983664
64MP0005389_reproductive_system_phenotype1.09517026
65MP0003315_abnormal_perineum_morphology1.08695792
66MP0000678_abnormal_parathyroid_gland1.08299493
67MP0004197_abnormal_fetal_growth/weight/1.07627727
68MP0009745_abnormal_behavioral_response1.06977072
69MP0003878_abnormal_ear_physiology1.06726081
70MP0005377_hearing/vestibular/ear_phenot1.06726081
71MP0002080_prenatal_lethality1.04696421
72MP0000313_abnormal_cell_death1.02993967
73MP0002735_abnormal_chemical_nociception1.00446493
74MP0003787_abnormal_imprinting0.95821104
75MP0005623_abnormal_meninges_morphology0.95345591
76MP0002086_abnormal_extraembryonic_tissu0.94803094
77MP0001501_abnormal_sleep_pattern0.93069232
78MP0005076_abnormal_cell_differentiation0.91902837
79MP0008872_abnormal_physiological_respon0.91463862
80MP0009046_muscle_twitch0.91331773
81MP0001986_abnormal_taste_sensitivity0.90559543
82MP0004142_abnormal_muscle_tone0.90007108
83MP0005647_abnormal_sex_gland0.88712578
84MP0004145_abnormal_muscle_electrophysio0.86373085
85MP0000049_abnormal_middle_ear0.85208927
86MP0002019_abnormal_tumor_incidence0.84216134
87MP0001293_anophthalmia0.84026073
88MP0004808_abnormal_hematopoietic_stem0.83485019
89MP0003937_abnormal_limbs/digits/tail_de0.82930322
90MP0006035_abnormal_mitochondrial_morpho0.82258289
91MP0003941_abnormal_skin_development0.81283646
92MP0000647_abnormal_sebaceous_gland0.81234539
93MP0003936_abnormal_reproductive_system0.79852347
94MP0001764_abnormal_homeostasis0.79690213
95MP0004742_abnormal_vestibular_system0.78728185
96MP0005395_other_phenotype0.77899471
97MP0009672_abnormal_birth_weight0.76214938
98MP0002928_abnormal_bile_duct0.75515758
99MP0004924_abnormal_behavior0.75129800
100MP0005386_behavior/neurological_phenoty0.75129800
101MP0004133_heterotaxia0.75043492
102MP0001963_abnormal_hearing_physiology0.74743397
103MP0003938_abnormal_ear_development0.74596832
104MP0005645_abnormal_hypothalamus_physiol0.73894115
105MP0003119_abnormal_digestive_system0.70693499
106MP0001188_hyperpigmentation0.69863199
107MP0004215_abnormal_myocardial_fiber0.69533596
108MP0004043_abnormal_pH_regulation0.68460614
109MP0000778_abnormal_nervous_system0.68414254
110MP0004233_abnormal_muscle_weight0.68405514
111MP0003183_abnormal_peptide_metabolism0.67886159
112MP0005075_abnormal_melanosome_morpholog0.67189904
113MP0001970_abnormal_pain_threshold0.66492759
114MP0002067_abnormal_sensory_capabilities0.65450867
115MP0002102_abnormal_ear_morphology0.63805486
116MP0002733_abnormal_thermal_nociception0.63428945
117MP0002184_abnormal_innervation0.62996304
118MP0002638_abnormal_pupillary_reflex0.62941067
119MP0002572_abnormal_emotion/affect_behav0.62787618
120MP0002557_abnormal_social/conspecific_i0.61558574
121MP0009703_decreased_birth_body0.59733898
122MP0000026_abnormal_inner_ear0.59616225
123MP0005360_urolithiasis0.59038904
124MP0002734_abnormal_mechanical_nocicepti0.58890603
125MP0002229_neurodegeneration0.58655145
126MP0003567_abnormal_fetal_cardiomyocyte0.58155250
127MP0001915_intracranial_hemorrhage0.58072479
128MP0003861_abnormal_nervous_system0.57860281
129MP0000358_abnormal_cell_content/0.56940693
130MP0003635_abnormal_synaptic_transmissio0.56767559
131MP0001919_abnormal_reproductive_system0.56164104
132MP0000427_abnormal_hair_cycle0.55914234
133MP0003221_abnormal_cardiomyocyte_apopto0.55615688
134MP0005621_abnormal_cell_physiology0.55117375
135MP0000537_abnormal_urethra_morphology0.54945214
136MP0005384_cellular_phenotype0.54924493
137MP0006292_abnormal_olfactory_placode0.53736715
138MP0001727_abnormal_embryo_implantation0.53338378
139MP0008260_abnormal_autophagy0.52595099
140MP0003136_yellow_coat_color0.51445460
141MP0003115_abnormal_respiratory_system0.51178720
142MP0001661_extended_life_span0.50063276
143MP0005451_abnormal_body_composition0.48780690
144MP0000432_abnormal_head_morphology0.45745901
145MP0002092_abnormal_eye_morphology0.44994560
146MP0001849_ear_inflammation0.43487308
147MP0002269_muscular_atrophy0.39419841
148MP0004264_abnormal_extraembryonic_tissu0.38232249
149MP0000569_abnormal_digit_pigmentation0.35621317
150MP0005397_hematopoietic_system_phenotyp0.34945332
151MP0001545_abnormal_hematopoietic_system0.34945332
152MP0000428_abnormal_craniofacial_morphol0.33753646
153MP0006072_abnormal_retinal_apoptosis0.33001050
154MP0002396_abnormal_hematopoietic_system0.32884196
155MP0002233_abnormal_nose_morphology0.32385512
156MP0003755_abnormal_palate_morphology0.32239967
157MP0002114_abnormal_axial_skeleton0.32228375
158MP0002697_abnormal_eye_size0.31770838
159MP0002111_abnormal_tail_morphology0.31030068
160MP0005391_vision/eye_phenotype0.29848690
161MP0000490_abnormal_crypts_of0.29439305
162MP0003935_abnormal_craniofacial_develop0.29384306
163MP0002282_abnormal_trachea_morphology0.29148156

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.91205447
2Azoospermia (HP:0000027)6.63284942
3Abnormal spermatogenesis (HP:0008669)6.19408990
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.48705863
5Absent/shortened dynein arms (HP:0200106)5.48705863
6Abnormality of the lower motor neuron (HP:0002366)5.10753909
7Gonadotropin excess (HP:0000837)4.71938334
8Chromsome breakage (HP:0040012)4.50123962
9Abnormal respiratory motile cilium physiology (HP:0012261)4.45346711
10Chromosomal breakage induced by crosslinking agents (HP:0003221)4.22452494
11Abnormal respiratory epithelium morphology (HP:0012253)3.96163019
12Abnormal respiratory motile cilium morphology (HP:0005938)3.96163019
13Rhinitis (HP:0012384)3.92728821
14Chronic bronchitis (HP:0004469)3.65780009
15Impulsivity (HP:0100710)3.56589063
16Infertility (HP:0000789)3.56424525
1711 pairs of ribs (HP:0000878)3.44135480
18Abnormal ciliary motility (HP:0012262)3.39141382
19Supernumerary spleens (HP:0009799)3.38626702
20Male infertility (HP:0003251)3.37937629
21Amyotrophic lateral sclerosis (HP:0007354)3.37333615
22Selective tooth agenesis (HP:0001592)3.32918756
23Abnormality of the renal cortex (HP:0011035)3.28175208
24Degeneration of anterior horn cells (HP:0002398)3.24691576
25Abnormality of the anterior horn cell (HP:0006802)3.24691576
26Abnormality of chromosome stability (HP:0003220)3.23854739
27Pancreatic cysts (HP:0001737)3.07053224
28Medial flaring of the eyebrow (HP:0010747)3.06915466
29Abnormality of the labia minora (HP:0012880)3.05750328
30Shoulder girdle muscle weakness (HP:0003547)3.04913198
31Congenital stationary night blindness (HP:0007642)3.00164103
32Meckel diverticulum (HP:0002245)3.00039582
33Ectopic kidney (HP:0000086)2.97042497
34Upper motor neuron abnormality (HP:0002127)2.93468926
35Facial hemangioma (HP:0000329)2.90678031
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.90072062
37Carpal bone hypoplasia (HP:0001498)2.88963485
38Pancreatic fibrosis (HP:0100732)2.87698346
39Degeneration of the lateral corticospinal tracts (HP:0002314)2.84319649
40Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.84319649
41Abnormality of the ileum (HP:0001549)2.80549745
42Abnormality of midbrain morphology (HP:0002418)2.78393286
43Molar tooth sign on MRI (HP:0002419)2.78393286
44Methylmalonic acidemia (HP:0002912)2.76831686
45Fibular hypoplasia (HP:0003038)2.75908441
46Papillary thyroid carcinoma (HP:0002895)2.75202473
47Abnormality of the preputium (HP:0100587)2.75066141
48Nephronophthisis (HP:0000090)2.72026179
49Ependymoma (HP:0002888)2.70553376
50Rimmed vacuoles (HP:0003805)2.70099436
51Birth length less than 3rd percentile (HP:0003561)2.68080891
52Breast hypoplasia (HP:0003187)2.65044389
53Medulloblastoma (HP:0002885)2.62553656
54Horizontal nystagmus (HP:0000666)2.61099802
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.60507701
56Abnormality of alanine metabolism (HP:0010916)2.60507701
57Hyperalaninemia (HP:0003348)2.60507701
58Congenital primary aphakia (HP:0007707)2.59815404
59Gait imbalance (HP:0002141)2.59815400
60True hermaphroditism (HP:0010459)2.59089187
61Abnormality of DNA repair (HP:0003254)2.55482020
62Absent radius (HP:0003974)2.55099663
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51235392
64Abnormal protein N-linked glycosylation (HP:0012347)2.51235392
65Abnormal protein glycosylation (HP:0012346)2.51235392
66Abnormal glycosylation (HP:0012345)2.51235392
67Spontaneous abortion (HP:0005268)2.51045450
68Absent thumb (HP:0009777)2.49507930
69Duodenal stenosis (HP:0100867)2.49233983
70Small intestinal stenosis (HP:0012848)2.49233983
71Attenuation of retinal blood vessels (HP:0007843)2.49029440
72Nephrogenic diabetes insipidus (HP:0009806)2.47452604
73Type I transferrin isoform profile (HP:0003642)2.42517457
74Absent forearm bone (HP:0003953)2.39659350
75Aplasia involving forearm bones (HP:0009822)2.39659350
76Nasal polyposis (HP:0100582)2.39647718
77Type II lissencephaly (HP:0007260)2.39362882
78Aplasia/Hypoplasia of the tibia (HP:0005772)2.36791626
79Methylmalonic aciduria (HP:0012120)2.32127434
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.31551846
81Premature ovarian failure (HP:0008209)2.31533092
82Aplasia/Hypoplasia of the sternum (HP:0006714)2.31048868
83Nephroblastoma (Wilms tumor) (HP:0002667)2.30799019
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30159175
85Sloping forehead (HP:0000340)2.30128445
86Rhabdomyosarcoma (HP:0002859)2.29668783
87Genital tract atresia (HP:0001827)2.28062732
88Congenital, generalized hypertrichosis (HP:0004540)2.27975803
89Duplicated collecting system (HP:0000081)2.27070292
90Abolished electroretinogram (ERG) (HP:0000550)2.25273700
91Scotoma (HP:0000575)2.23326110
92Cystic liver disease (HP:0006706)2.21088774
93Bronchiectasis (HP:0002110)2.20980288
94Missing ribs (HP:0000921)2.20661159
95Patellar aplasia (HP:0006443)2.20097414
96Colon cancer (HP:0003003)2.19828760
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18339601
98Hyperglycinemia (HP:0002154)2.18177318
99Facial cleft (HP:0002006)2.17566253
100Oligodactyly (hands) (HP:0001180)2.15448970
101Shawl scrotum (HP:0000049)2.15105698
102Breast carcinoma (HP:0003002)2.14750757
103Gaze-evoked nystagmus (HP:0000640)2.14251051
104Vaginal atresia (HP:0000148)2.13785528
105Tubular atrophy (HP:0000092)2.13555376
106Short tibia (HP:0005736)2.13166143
107Abnormality of the carotid arteries (HP:0005344)2.12073216
108Oligodactyly (HP:0012165)2.11943831
109Abnormal rod and cone electroretinograms (HP:0008323)2.11729443
110Sandal gap (HP:0001852)2.10928507
111Embryonal renal neoplasm (HP:0011794)2.09896739
112Abnormal lung lobation (HP:0002101)2.06275105
113Abnormality of the astrocytes (HP:0100707)2.05709545
114Astrocytoma (HP:0009592)2.05709545
115Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.03985773
116Volvulus (HP:0002580)2.03401247
117Bony spicule pigmentary retinopathy (HP:0007737)2.03263300
118Aplasia/Hypoplasia of the fibula (HP:0006492)2.02248610
119Short thumb (HP:0009778)2.01720188
120Aplasia/Hypoplasia of the patella (HP:0006498)2.00644241
121Astigmatism (HP:0000483)1.97685345
122Neoplasm of the oral cavity (HP:0100649)1.97656242
123Abnormality of the renal medulla (HP:0100957)1.97471589
124Heterotopia (HP:0002282)1.96553550
125Abnormality of the corticospinal tract (HP:0002492)1.96077635
126Tubulointerstitial nephritis (HP:0001970)1.95617493
127Horseshoe kidney (HP:0000085)1.95055356
128Poor coordination (HP:0002370)1.93975389
129Increased nuchal translucency (HP:0010880)1.92794351
130Tubulointerstitial abnormality (HP:0001969)1.92636703
131Abnormality of the duodenum (HP:0002246)1.92055489
132Biliary tract neoplasm (HP:0100574)1.91703258
133Prominent nose (HP:0000448)1.90481968
134Multicystic kidney dysplasia (HP:0000003)1.90118698
135Aplasia/Hypoplasia of the earlobes (HP:0009906)1.89119878
136Preaxial hand polydactyly (HP:0001177)1.88176132
137Bronchitis (HP:0012387)1.88114100
138Neoplasm of striated muscle (HP:0009728)1.88028168
139Capillary hemangiomas (HP:0005306)1.86836912
140Genetic anticipation (HP:0003743)1.86336739
141Hypoplastic iliac wings (HP:0002866)1.85866922
142Abnormality of the phalanges of the 5th finger (HP:0004213)1.85581925
143Glioma (HP:0009733)1.84963311
144Abnormality of the vitamin B12 metabolism (HP:0004341)1.84511438
145Pendular nystagmus (HP:0012043)1.84237809
146Decreased subcutaneous fat (HP:0001002)1.83513269
147Renal cortical cysts (HP:0000803)1.81660129
148Abnormality of vitamin B metabolism (HP:0004340)1.80961263
149Agnosia (HP:0010524)1.80505284
150Aplasia/Hypoplasia of the tongue (HP:0010295)1.79970189
151Abnormality of the renal collecting system (HP:0004742)1.79272075
152Hypoplasia of the radius (HP:0002984)1.79119309
153Short ribs (HP:0000773)1.78302830
154Secondary amenorrhea (HP:0000869)1.77931506
155Small hand (HP:0200055)1.77756899
156Cutaneous melanoma (HP:0012056)1.77316072
157Congenital hepatic fibrosis (HP:0002612)1.77247972
158Ureteral duplication (HP:0000073)1.77205621
159Lip pit (HP:0100267)1.77046696
160Ankle contracture (HP:0006466)1.76740296
161Abnormality of the nasal mucosa (HP:0000433)1.76212916
162Severe visual impairment (HP:0001141)1.75718369
163Retinitis pigmentosa (HP:0000510)1.74974017
164Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74904070
165Clubbing of toes (HP:0100760)1.74695403
166Cafe-au-lait spot (HP:0000957)1.74602590
167Progressive cerebellar ataxia (HP:0002073)1.73807481
168Aplasia/hypoplasia of the humerus (HP:0006507)1.73695438
169Fair hair (HP:0002286)1.71995909
170Hypoplasia of the uterus (HP:0000013)1.71490264
171Abnormality of glycine metabolism (HP:0010895)1.71378305
172Abnormality of serine family amino acid metabolism (HP:0010894)1.71378305
173Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69733617
174Sclerocornea (HP:0000647)1.69606081

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK45.43362596
2PDK35.43362596
3CDC74.87358017
4FRK4.82225378
5CDK123.92289326
6ACVR1B3.66404183
7WEE13.52377178
8CDK193.47817926
9PDK23.46734085
10NEK23.07296234
11TTK2.85112708
12MAP4K22.56396973
13OXSR12.56220306
14PLK42.46325376
15BUB12.40273004
16PNCK2.29431798
17ADRBK22.17350193
18PLK12.12167780
19MUSK2.11816700
20STK38L2.11334590
21GRK12.08175287
22NUAK11.79023762
23TAOK31.73666951
24MAPK131.66330976
25ATR1.65915064
26ICK1.62213393
27CHEK21.60402482
28STK31.53023369
29BRSK21.52802355
30CHEK11.51150982
31SRPK11.46975862
32TLK11.44784961
33NEK11.41985806
34CAMK1G1.40675480
35CSF1R1.40356832
36PRKD31.39644876
37CASK1.32804517
38BRD41.31628833
39CDK71.26015841
40TESK11.25643949
41ATM1.19793367
42MKNK21.18238597
43EIF2AK11.18132968
44PLK31.14615789
45DYRK31.10195738
46INSRR1.08384709
47MELK1.07726795
48AURKB1.04112339
49TYRO31.03331321
50LATS10.97912560
51LATS20.96848165
52PASK0.92933354
53MKNK10.92641759
54BRSK10.92126825
55BCKDK0.91644362
56CDK40.89443262
57PBK0.87338767
58BRAF0.86208319
59STK160.86135776
60CDK20.84627964
61AURKA0.83867813
62FGR0.83166919
63NTRK30.81688322
64MAP3K60.81042054
65BMX0.77502414
66MAP3K40.76145908
67CSNK1G10.73237765
68CDK10.72856700
69STK240.72035755
70TSSK60.69906065
71CCNB10.68617179
72PTK2B0.68416268
73TXK0.68320533
74MTOR0.67660154
75CSNK1G20.67455113
76NEK90.66525036
77ADRBK10.65590077
78EPHA20.65258729
79MST40.64895448
80STK40.64856877
81MAP2K70.62195293
82KDR0.61323877
83PRKCE0.61168316
84CDK90.59535144
85STK380.58335751
86TAF10.58080149
87WNK30.56026656
88SGK10.55967816
89EEF2K0.53154002
90FGFR20.51031797
91TIE10.49710235
92EIF2AK30.49288177
93MAP3K90.48943163
94IGF1R0.48603431
95CSNK1G30.48533556
96PIK3CG0.48212368
97NLK0.47838233
98MAP3K80.47614689
99PRKCG0.47041743
100GRK70.46928539
101PRKCQ0.45522892
102TRIM280.45456956
103CAMK10.45227659
104CSNK1E0.44874246
105CSNK1D0.44819071
106PRKDC0.44589391
107MAP3K50.44426877
108TEC0.44394376
109STK110.44199425
110PDGFRB0.43990685
111EGFR0.43766739
112CSNK2A20.43270766
113SCYL20.42027382
114RPS6KB20.41347327
115PAK10.39815503
116CDK80.39749726
117EPHA40.39497545
118PINK10.39310053
119TESK20.38683072
120NME10.37936936
121BCR0.37704410
122PLK20.37100175
123WNK40.36346144
124GSK3B0.35932432
125CSNK2A10.35524230
126ITK0.34556181
127DAPK20.34512292
128AKT30.34366453
129MST1R0.34270189
130RPS6KA50.34089311
131VRK10.33691908
132STK100.32875895
133TNK20.32105164
134BMPR1B0.31620504
135CAMK2A0.31512943
136WNK10.31166389
137MAP2K20.30989203
138STK390.29239133
139ERBB40.29145766
140MARK10.28066750
141MAPK140.28045258
142CDK50.27385721
143MET0.26055558
144ALK0.25302341
145MAPKAPK50.25230329
146CSNK1A1L0.25150999
147PRKCI0.24881895
148MAPK100.24620468
149PAK40.23307872
150ZAK0.23303613
151TGFBR10.22660075
152PRKAA10.22325398
153PRKACA0.21795256
154CSNK1A10.21558004
155CDK30.21397695
156MAPK80.20968740
157TAOK10.19748979
158RPS6KA40.17034760
159MAPK10.17019129
160RPS6KB10.16691286
161DYRK1A0.15264187
162AKT10.15091828
163MARK30.14668470

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.68313765
2Basal transcription factors_Homo sapiens_hsa030224.22403588
3Mismatch repair_Homo sapiens_hsa034303.89407026
4DNA replication_Homo sapiens_hsa030303.75666203
5Homologous recombination_Homo sapiens_hsa034403.68554965
6RNA transport_Homo sapiens_hsa030133.58821025
7Fanconi anemia pathway_Homo sapiens_hsa034603.57261861
8Cell cycle_Homo sapiens_hsa041103.27407220
9RNA polymerase_Homo sapiens_hsa030202.86246631
10Nucleotide excision repair_Homo sapiens_hsa034202.86233082
11Phototransduction_Homo sapiens_hsa047442.84379424
12Spliceosome_Homo sapiens_hsa030402.73500131
13mRNA surveillance pathway_Homo sapiens_hsa030152.72319698
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67374894
15Proteasome_Homo sapiens_hsa030502.62539657
16Non-homologous end-joining_Homo sapiens_hsa034502.39814689
17Base excision repair_Homo sapiens_hsa034102.28739086
18Vitamin B6 metabolism_Homo sapiens_hsa007502.28095649
19Oocyte meiosis_Homo sapiens_hsa041142.22485708
20RNA degradation_Homo sapiens_hsa030182.22455258
21Selenocompound metabolism_Homo sapiens_hsa004502.11316915
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.96450489
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.92378338
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89102979
25Nicotine addiction_Homo sapiens_hsa050331.86833484
26One carbon pool by folate_Homo sapiens_hsa006701.81265276
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81199068
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80037126
29Pyrimidine metabolism_Homo sapiens_hsa002401.75843717
30Dorso-ventral axis formation_Homo sapiens_hsa043201.75775617
31Protein export_Homo sapiens_hsa030601.63321814
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.54710991
33Nitrogen metabolism_Homo sapiens_hsa009101.54336057
34p53 signaling pathway_Homo sapiens_hsa041151.50633922
35Tryptophan metabolism_Homo sapiens_hsa003801.49483319
36beta-Alanine metabolism_Homo sapiens_hsa004101.48740705
37Butanoate metabolism_Homo sapiens_hsa006501.47080463
38Taste transduction_Homo sapiens_hsa047421.43353088
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37860586
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36887588
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36792622
42Retinol metabolism_Homo sapiens_hsa008301.33466217
43Olfactory transduction_Homo sapiens_hsa047401.30844303
44Sulfur relay system_Homo sapiens_hsa041221.30283812
45ABC transporters_Homo sapiens_hsa020101.30201606
46Purine metabolism_Homo sapiens_hsa002301.24731585
47Parkinsons disease_Homo sapiens_hsa050121.18725203
48Caffeine metabolism_Homo sapiens_hsa002321.16592842
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14763686
50Oxidative phosphorylation_Homo sapiens_hsa001901.14706839
51Pentose phosphate pathway_Homo sapiens_hsa000301.13705111
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.13285542
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.09845584
54Epstein-Barr virus infection_Homo sapiens_hsa051691.07577587
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05698388
56Peroxisome_Homo sapiens_hsa041461.00790550
57Primary immunodeficiency_Homo sapiens_hsa053400.97985991
58Linoleic acid metabolism_Homo sapiens_hsa005910.96897861
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96805634
60Pyruvate metabolism_Homo sapiens_hsa006200.96314934
61Chemical carcinogenesis_Homo sapiens_hsa052040.95831386
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95779285
63Sulfur metabolism_Homo sapiens_hsa009200.94784762
64Morphine addiction_Homo sapiens_hsa050320.91576207
65Collecting duct acid secretion_Homo sapiens_hsa049660.90976729
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.88332619
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87797266
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.83799575
69Huntingtons disease_Homo sapiens_hsa050160.82295555
70TGF-beta signaling pathway_Homo sapiens_hsa043500.80757416
71Calcium signaling pathway_Homo sapiens_hsa040200.78702509
72Herpes simplex infection_Homo sapiens_hsa051680.78474168
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77896728
74N-Glycan biosynthesis_Homo sapiens_hsa005100.74076362
75Serotonergic synapse_Homo sapiens_hsa047260.70024660
76Glycerolipid metabolism_Homo sapiens_hsa005610.69412554
77Viral carcinogenesis_Homo sapiens_hsa052030.69318053
78HTLV-I infection_Homo sapiens_hsa051660.68526998
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67913031
80Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67084838
81Biosynthesis of amino acids_Homo sapiens_hsa012300.62966360
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.62205626
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61421883
84Lysine degradation_Homo sapiens_hsa003100.60751035
85Circadian entrainment_Homo sapiens_hsa047130.60088388
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59324044
87Glutamatergic synapse_Homo sapiens_hsa047240.58493586
88Antigen processing and presentation_Homo sapiens_hsa046120.58108149
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56914786
90Fatty acid degradation_Homo sapiens_hsa000710.55560844
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54847732
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.54706003
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.53549658
94Hippo signaling pathway_Homo sapiens_hsa043900.51984793
95Hedgehog signaling pathway_Homo sapiens_hsa043400.51775347
96MicroRNAs in cancer_Homo sapiens_hsa052060.50848918
97Thyroid cancer_Homo sapiens_hsa052160.50813683
98Ether lipid metabolism_Homo sapiens_hsa005650.46205642
99GABAergic synapse_Homo sapiens_hsa047270.45731186
100Glucagon signaling pathway_Homo sapiens_hsa049220.44099420
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41637969
102Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40768742
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40755265
104Fatty acid biosynthesis_Homo sapiens_hsa000610.40743420
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39551901
106Tight junction_Homo sapiens_hsa045300.39079241
107Steroid biosynthesis_Homo sapiens_hsa001000.38767460
108Cyanoamino acid metabolism_Homo sapiens_hsa004600.37991506
109Fatty acid elongation_Homo sapiens_hsa000620.37671801
110Systemic lupus erythematosus_Homo sapiens_hsa053220.36955088
111Basal cell carcinoma_Homo sapiens_hsa052170.36604969
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35241536
113Adherens junction_Homo sapiens_hsa045200.34524454
114Asthma_Homo sapiens_hsa053100.33645908
115Salivary secretion_Homo sapiens_hsa049700.33513895
116Carbon metabolism_Homo sapiens_hsa012000.33236151
117Propanoate metabolism_Homo sapiens_hsa006400.32496023
118Drug metabolism - other enzymes_Homo sapiens_hsa009830.32441600
119Insulin secretion_Homo sapiens_hsa049110.30694511
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30277051
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28919245
122Glutathione metabolism_Homo sapiens_hsa004800.28464857
123Colorectal cancer_Homo sapiens_hsa052100.27910516
124Notch signaling pathway_Homo sapiens_hsa043300.27746475
125mTOR signaling pathway_Homo sapiens_hsa041500.27459861
126Ribosome_Homo sapiens_hsa030100.27225269
127Influenza A_Homo sapiens_hsa051640.27098200
128Small cell lung cancer_Homo sapiens_hsa052220.26617594
129Regulation of autophagy_Homo sapiens_hsa041400.23544153
130Wnt signaling pathway_Homo sapiens_hsa043100.22448474
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.22044321
132Circadian rhythm_Homo sapiens_hsa047100.21463338
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18244189
134FoxO signaling pathway_Homo sapiens_hsa040680.15291716
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14624040
136Prostate cancer_Homo sapiens_hsa052150.13167740
137Arachidonic acid metabolism_Homo sapiens_hsa005900.12872490
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.12795700
139Pathways in cancer_Homo sapiens_hsa052000.11574703
140Ovarian steroidogenesis_Homo sapiens_hsa049130.11533858
141Metabolic pathways_Homo sapiens_hsa011000.11188463
142Inositol phosphate metabolism_Homo sapiens_hsa005620.09844111
143AMPK signaling pathway_Homo sapiens_hsa041520.09645159
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07738459
145Renal cell carcinoma_Homo sapiens_hsa052110.06928375
146Pancreatic cancer_Homo sapiens_hsa052120.06118527
147Fructose and mannose metabolism_Homo sapiens_hsa000510.05902509
148HIF-1 signaling pathway_Homo sapiens_hsa040660.05818414
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.05106465
150Vitamin digestion and absorption_Homo sapiens_hsa049770.04900214
151VEGF signaling pathway_Homo sapiens_hsa043700.04543231
152Fat digestion and absorption_Homo sapiens_hsa049750.03612305
153Estrogen signaling pathway_Homo sapiens_hsa049150.03384672
154Alcoholism_Homo sapiens_hsa050340.00687412
155Folate biosynthesis_Homo sapiens_hsa00790-0.0166722
156Choline metabolism in cancer_Homo sapiens_hsa05231-0.0106308

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