STK32C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.92832280
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.56216146
3locomotory exploration behavior (GO:0035641)6.37085889
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.18887133
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.69637166
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.54311316
7vocalization behavior (GO:0071625)5.52799637
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.38690009
9synaptic vesicle exocytosis (GO:0016079)5.37874397
10regulation of synapse structural plasticity (GO:0051823)5.29688483
11regulation of synaptic vesicle exocytosis (GO:2000300)5.25450324
12glutamate secretion (GO:0014047)5.24646773
13regulation of glutamate receptor signaling pathway (GO:1900449)5.18984770
14regulation of neuronal synaptic plasticity (GO:0048168)5.05485639
15regulation of long-term neuronal synaptic plasticity (GO:0048169)5.04681749
16fusion of sperm to egg plasma membrane (GO:0007342)4.99085166
17sperm motility (GO:0030317)4.74729930
18regulation of synaptic vesicle transport (GO:1902803)4.68997393
19exploration behavior (GO:0035640)4.65439737
20neurotransmitter secretion (GO:0007269)4.63247715
21layer formation in cerebral cortex (GO:0021819)4.60686461
22acrosome reaction (GO:0007340)4.57994907
23protein localization to synapse (GO:0035418)4.56002081
24dendritic spine morphogenesis (GO:0060997)4.53038312
25sperm capacitation (GO:0048240)4.45519680
26neuronal action potential propagation (GO:0019227)4.40657857
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.39322408
28neurotransmitter-gated ion channel clustering (GO:0072578)4.39003295
29calcium ion-dependent exocytosis (GO:0017156)4.37073025
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.27945604
31chromosome condensation (GO:0030261)4.19407302
32prepulse inhibition (GO:0060134)4.18782657
33regulation of dendritic spine morphogenesis (GO:0061001)4.12899228
34neuromuscular process controlling balance (GO:0050885)4.09182481
35positive regulation of membrane potential (GO:0045838)4.08885293
36long-term memory (GO:0007616)4.05049098
37response to acidic pH (GO:0010447)4.00922288
38synaptic transmission, glutamatergic (GO:0035249)4.00663284
39positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.99222769
40gamma-aminobutyric acid transport (GO:0015812)3.98912090
41activation of protein kinase A activity (GO:0034199)3.95545180
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.95140535
43auditory behavior (GO:0031223)3.94171222
44plasma membrane fusion (GO:0045026)3.92073102
45positive regulation of synaptic transmission, GABAergic (GO:0032230)3.92019863
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.91493034
47positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.91064102
48proline transport (GO:0015824)3.88745720
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.86156199
50positive regulation of neurotransmitter transport (GO:0051590)3.82792650
51neuron-neuron synaptic transmission (GO:0007270)3.82410017
52regulation of synaptic plasticity (GO:0048167)3.82346538
53cellular potassium ion homeostasis (GO:0030007)3.74578792
54cell-cell junction maintenance (GO:0045217)3.72719811
55neuron cell-cell adhesion (GO:0007158)3.72136637
56DNA packaging (GO:0006323)3.70562127
57sodium ion export (GO:0071436)3.69692915
58glycine transport (GO:0015816)3.69403422
59positive regulation of neurotransmitter secretion (GO:0001956)3.68553754
60response to auditory stimulus (GO:0010996)3.66348531
61glutamate receptor signaling pathway (GO:0007215)3.65160104
62regulation of postsynaptic membrane potential (GO:0060078)3.64817022
63neurotransmitter transport (GO:0006836)3.59139320
64neuronal ion channel clustering (GO:0045161)3.53645759
65regulation of T-helper 2 cell differentiation (GO:0045628)3.51186853
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.47299663
67regulation of neurotransmitter secretion (GO:0046928)3.45569538
68negative regulation of inclusion body assembly (GO:0090084)3.45340561
69transmission of nerve impulse (GO:0019226)3.45105687
70regulation of neurotransmitter levels (GO:0001505)3.42336675
71regulation of ARF GTPase activity (GO:0032312)3.41991401
72cerebral cortex neuron differentiation (GO:0021895)3.41949517
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.40751510
74regulation of female receptivity (GO:0045924)3.37577268
75regulation of dendritic spine development (GO:0060998)3.34131546
76adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.33491185
77regulation of ARF protein signal transduction (GO:0032012)3.33278688
78long-term synaptic potentiation (GO:0060291)3.33054070
79sexual reproduction (GO:0019953)3.32223286
80regulation of neurotransmitter transport (GO:0051588)3.31297514
81negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31072457
82dendritic spine organization (GO:0097061)3.29867216
83neuromuscular process controlling posture (GO:0050884)3.29507137
84dopamine receptor signaling pathway (GO:0007212)3.28488188
85striatum development (GO:0021756)3.28092618
86synaptic transmission, dopaminergic (GO:0001963)3.27150270
87adenosine receptor signaling pathway (GO:0001973)3.25037914
88vesicle transport along microtubule (GO:0047496)3.23088876
89regulation of vesicle fusion (GO:0031338)3.18370275
90positive regulation of synapse maturation (GO:0090129)3.18034686
91membrane hyperpolarization (GO:0060081)3.17810247
92positive regulation of synaptic transmission (GO:0050806)3.15976350
93positive regulation of dendritic spine development (GO:0060999)3.15659444
94neuromuscular process (GO:0050905)3.14309466
95amino acid import (GO:0043090)3.14218266
96single strand break repair (GO:0000012)3.12586121
97cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12323780
98membrane depolarization (GO:0051899)3.12067254
99synaptic vesicle endocytosis (GO:0048488)3.11393639
100regulation of voltage-gated calcium channel activity (GO:1901385)3.11344477
101behavioral response to cocaine (GO:0048148)3.11293019
102learning (GO:0007612)3.09098631
103response to pheromone (GO:0019236)3.06262037
104dendrite morphogenesis (GO:0048813)3.05668125
105visual learning (GO:0008542)3.05449847
106membrane depolarization during action potential (GO:0086010)3.04985677
107behavioral defense response (GO:0002209)3.04084808
108behavioral fear response (GO:0001662)3.04084808
109cell communication by electrical coupling (GO:0010644)3.04068484
110response to amphetamine (GO:0001975)3.03892087
111regulation of inclusion body assembly (GO:0090083)3.03690819
112L-amino acid import (GO:0043092)3.02972330
113regulation of synaptic transmission (GO:0050804)3.02208038
114regulation of glutamate secretion (GO:0014048)2.98144302
115social behavior (GO:0035176)2.96660968
116intraspecies interaction between organisms (GO:0051703)2.96660968
117neuron recognition (GO:0008038)2.96597958
118acidic amino acid transport (GO:0015800)2.94162073
119regulation of synaptic transmission, GABAergic (GO:0032228)2.93590507
120mating behavior (GO:0007617)2.92782180
121spermatid development (GO:0007286)2.92530759
122establishment of mitochondrion localization (GO:0051654)2.88745822
123cranial nerve morphogenesis (GO:0021602)2.87135401
124negative regulation of erythrocyte differentiation (GO:0045647)2.86852623
125L-glutamate transport (GO:0015813)2.81552042
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80651580
127spermatid nucleus differentiation (GO:0007289)2.78816489
128microtubule depolymerization (GO:0007019)2.78561876
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.77534481
130microtubule polymerization or depolymerization (GO:0031109)2.76466976
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.75876893
132mitochondrion transport along microtubule (GO:0047497)2.75876893
133regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.75070004
134protein retention in ER lumen (GO:0006621)2.74908709
135cytoskeletal anchoring at plasma membrane (GO:0007016)2.73031621
136protein polyglutamylation (GO:0018095)2.72177513
137regulation of regulated secretory pathway (GO:1903305)2.69937664
138microtubule severing (GO:0051013)2.68830838
139cellular component maintenance (GO:0043954)2.67428659
140phosphatidylethanolamine biosynthetic process (GO:0006646)2.67267776
141negative regulation of granulocyte differentiation (GO:0030853)2.66762036
142cerebellar granule cell differentiation (GO:0021707)2.66615290
143positive regulation of mast cell degranulation (GO:0043306)2.62909164
144positive regulation of mast cell activation involved in immune response (GO:0033008)2.62909164
145dicarboxylic acid transport (GO:0006835)2.60017581
146regulation of synapse maturation (GO:0090128)2.59496272
147regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57676657
148positive regulation of type 2 immune response (GO:0002830)2.57408210
149rRNA methylation (GO:0031167)2.57389954
150regulation of early endosome to late endosome transport (GO:2000641)2.57179489
151cellular response to pH (GO:0071467)2.55477137
152axonemal dynein complex assembly (GO:0070286)2.54725537
153cell junction maintenance (GO:0034331)2.54483264
154peptidyl-arginine omega-N-methylation (GO:0035247)2.54278812
155regulation of defense response to virus by virus (GO:0050690)2.53905562
156regulation of leukocyte degranulation (GO:0043300)2.53887559
157RNA destabilization (GO:0050779)2.53711376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60977505
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.97152671
3RARB_27405468_Chip-Seq_BRAIN_Mouse3.49064504
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08803632
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03434027
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03323089
7DROSHA_22980978_ChIP-Seq_HELA_Human2.88828632
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.82793811
9* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78796866
10* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78796866
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.72993146
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.70005008
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.64896593
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61931661
15GBX2_23144817_ChIP-Seq_PC3_Human2.61784425
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56235281
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53832850
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42990299
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.42031824
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41320032
21VDR_21846776_ChIP-Seq_THP-1_Human2.40370270
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.40271182
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.36133929
24* P68_20966046_ChIP-Seq_HELA_Human2.34666254
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33978918
26EZH2_27294783_Chip-Seq_ESCs_Mouse2.31620992
27* ELF1_20517297_ChIP-Seq_JURKAT_Human2.28452534
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.24820424
29TET1_21451524_ChIP-Seq_MESCs_Mouse2.12412335
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.00675056
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97450398
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.96096269
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.92788880
34BCL6_27268052_Chip-Seq_Bcells_Human1.92492984
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91102522
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85191399
37AR_21572438_ChIP-Seq_LNCaP_Human1.85162074
38* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84698929
39* SA1_27219007_Chip-Seq_ERYTHROID_Human1.80070784
40BCOR_27268052_Chip-Seq_Bcells_Human1.79618950
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.77551193
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77515352
43TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73146934
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.67042967
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.64405248
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.62370620
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60938578
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55312583
49* KDM2B_26808549_Chip-Seq_K562_Human1.53998311
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.53628670
51* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.52681858
52SA1_27219007_Chip-Seq_Bcells_Human1.51865723
53E2F1_20622854_ChIP-Seq_HELA_Human1.50905651
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50486842
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.50366004
56* RACK7_27058665_Chip-Seq_MCF-7_Human1.49143016
57PHF8_20622854_ChIP-Seq_HELA_Human1.49140590
58* CTCF_20526341_ChIP-Seq_ESCs_Human1.49015514
59* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.47036334
60TCF7_22412390_ChIP-Seq_EML_Mouse1.45428394
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44832814
62MYC_22102868_ChIP-Seq_BL_Human1.44468609
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40679234
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40677209
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40372091
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.40135156
67VDR_24763502_ChIP-Seq_THP-1_Human1.38333912
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.36613245
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36300077
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33450134
71YY1_22570637_ChIP-Seq_MALME-3M_Human1.32852135
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32777468
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32582404
74* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31513388
75CREB1_26743006_Chip-Seq_LNCaP_Human1.31496095
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30858715
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.29224460
78E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28747542
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28590184
80SMAD4_21799915_ChIP-Seq_A2780_Human1.28137683
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26780928
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.25520822
83TP63_22573176_ChIP-Seq_HFKS_Human1.24932947
84* MAF_26560356_Chip-Seq_TH2_Human1.23442710
85PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22208730
86* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21352775
87AR_19668381_ChIP-Seq_PC3_Human1.19274928
88ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18779278
89SMAD_19615063_ChIP-ChIP_OVARY_Human1.17522243
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15590353
91P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15444070
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.14952210
93* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14442618
94NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14094545
95CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13003721
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.12829253
97CTCF_26484167_Chip-Seq_Bcells_Mouse1.11643153
98GATA1_19941827_ChIP-Seq_MEL_Mouse1.11318659
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10327410
100KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10196420
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09405041
102EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.08372567
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08116108
104* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.07762216
105JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.07680076
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07628609
107KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07202264
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07013716
109RARA_24833708_ChIP-Seq_LIVER_Mouse1.06949458
110CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06941796
111VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05904617
112ETS1_21867929_ChIP-Seq_TH2_Mouse1.05823956
113TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05306661
114CTCF_21964334_Chip-Seq_Bcells_Human1.05144314
115* CTCF_27219007_Chip-Seq_Bcells_Human1.04611677
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04072051
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03487930
118SPI1_20517297_ChIP-Seq_HL60_Human1.03435958
119KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02855875
120CTCF_21964334_ChIP-Seq_BJAB-B_Human1.02515981
121SMAD3_21741376_ChIP-Seq_EPCs_Human1.02333107
122FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02259160
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.02196973
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02123476
125PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01635847
126STAT3_23295773_ChIP-Seq_U87_Human1.00905223
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.99149241
128TAF15_26573619_Chip-Seq_HEK293_Human0.98858125
129ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98678206
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97854086
131DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96270761
132AR_25329375_ChIP-Seq_VCAP_Human0.95196357
133* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94981703
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93313173
135RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93280853
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93023447
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92800004
138YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91919852
139ZNF274_21170338_ChIP-Seq_K562_Hela0.91734260
140RXR_22108803_ChIP-Seq_LS180_Human0.91337115
141* KLF4_19829295_ChIP-Seq_ESCs_Human0.90999403
142SMAD4_21741376_ChIP-Seq_HESCs_Human0.89853167
143* SMAD3_21741376_ChIP-Seq_ESCs_Human0.89050591
144PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87932392
145KDM2B_26808549_Chip-Seq_JURKAT_Human0.87261802
146TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86656015
147* SMC4_20622854_ChIP-Seq_HELA_Human0.86416566
148LXR_22292898_ChIP-Seq_THP-1_Human0.86286077
149SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.86070533
150TCF4_23295773_ChIP-Seq_U87_Human0.85977004
151AHR_22903824_ChIP-Seq_MCF-7_Human0.85043676
152KDM2B_26808549_Chip-Seq_DND41_Human0.82710276
153ARNT_22903824_ChIP-Seq_MCF-7_Human0.81959615
154OCT4_19829295_ChIP-Seq_ESCs_Human0.81626518
155GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81369343
156P300_19829295_ChIP-Seq_ESCs_Human0.81069068
157ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80499978
158CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79429501
159TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78255346
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77486250
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77346605
162PRDM14_20953172_ChIP-Seq_ESCs_Human0.77028558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.52311395
2MP0002822_catalepsy5.21956476
3MP0005410_abnormal_fertilization4.52883681
4MP0003880_abnormal_central_pattern4.42782951
5MP0003635_abnormal_synaptic_transmissio4.42355450
6MP0004270_analgesia3.88540292
7MP0009745_abnormal_behavioral_response3.64410687
8MP0002063_abnormal_learning/memory/cond3.58501636
9MP0002064_seizures3.24730391
10MP0009046_muscle_twitch2.92957844
11MP0005423_abnormal_somatic_nervous2.86860261
12MP0001968_abnormal_touch/_nociception2.81963698
13MP0002572_abnormal_emotion/affect_behav2.80123788
14MP0005058_abnormal_lysosome_morphology2.77021328
15MP0001486_abnormal_startle_reflex2.72365357
16MP0002272_abnormal_nervous_system2.54153567
17MP0002734_abnormal_mechanical_nocicepti2.53072278
18MP0001501_abnormal_sleep_pattern2.25973268
19MP0009780_abnormal_chondrocyte_physiolo2.12025703
20MP0002909_abnormal_adrenal_gland2.10449554
21MP0002736_abnormal_nociception_after1.97477227
22MP0008569_lethality_at_weaning1.97014195
23MP0002733_abnormal_thermal_nociception1.96175992
24MP0001970_abnormal_pain_threshold1.95984046
25MP0004811_abnormal_neuron_physiology1.93668894
26MP0005670_abnormal_white_adipose1.92031601
27MP0004858_abnormal_nervous_system1.91420391
28MP0001348_abnormal_lacrimal_gland1.87480193
29MP0003123_paternal_imprinting1.87423799
30MP0003329_amyloid_beta_deposits1.87012689
31MP0000678_abnormal_parathyroid_gland1.82526861
32MP0001440_abnormal_grooming_behavior1.80422956
33MP0005646_abnormal_pituitary_gland1.79607897
34MP0002735_abnormal_chemical_nociception1.76831148
35MP0004924_abnormal_behavior1.74747417
36MP0005386_behavior/neurological_phenoty1.74747417
37MP0002249_abnormal_larynx_morphology1.74650075
38MP0000681_abnormal_thyroid_gland1.73249926
39MP0002557_abnormal_social/conspecific_i1.69105992
40MP0003879_abnormal_hair_cell1.65966975
41MP0009278_abnormal_bone_marrow1.64077490
42MP0002067_abnormal_sensory_capabilities1.63097633
43MP0004885_abnormal_endolymph1.52093167
44MP0003075_altered_response_to1.50476052
45MP0003698_abnormal_male_reproductive1.49056935
46MP0000955_abnormal_spinal_cord1.48559468
47MP0002184_abnormal_innervation1.48422832
48MP0003633_abnormal_nervous_system1.46218273
49MP0001529_abnormal_vocalization1.44556367
50MP0005310_abnormal_salivary_gland1.40465426
51MP0002066_abnormal_motor_capabilities/c1.39507345
52MP0005451_abnormal_body_composition1.38129027
53MP0000778_abnormal_nervous_system1.37206416
54MP0003436_decreased_susceptibility_to1.35115414
55MP0002882_abnormal_neuron_morphology1.31874402
56MP0001984_abnormal_olfaction1.28347131
57MP0003787_abnormal_imprinting1.24409716
58MP0008961_abnormal_basal_metabolism1.23520047
59MP0005167_abnormal_blood-brain_barrier1.20705378
60MP0002132_abnormal_respiratory_system1.20644148
61MP0008872_abnormal_physiological_respon1.18112744
62MP0003631_nervous_system_phenotype1.17605722
63MP0003183_abnormal_peptide_metabolism1.17594839
64MP0008874_decreased_physiological_sensi1.17369337
65MP0001177_atelectasis1.15131383
66MP0003283_abnormal_digestive_organ1.14211603
67MP0000569_abnormal_digit_pigmentation1.11993013
68MP0005377_hearing/vestibular/ear_phenot1.11820432
69MP0003878_abnormal_ear_physiology1.11820432
70MP0001502_abnormal_circadian_rhythm1.11267975
71MP0002653_abnormal_ependyma_morphology1.10048340
72MP0001905_abnormal_dopamine_level1.08916922
73MP0003690_abnormal_glial_cell1.08361459
74MP0010234_abnormal_vibrissa_follicle1.04353140
75MP0000013_abnormal_adipose_tissue1.03562114
76MP0005645_abnormal_hypothalamus_physiol1.03083100
77MP0001929_abnormal_gametogenesis1.02076912
78MP0002152_abnormal_brain_morphology1.01816825
79MP0002419_abnormal_innate_immunity1.01085932
80MP0002148_abnormal_hypersensitivity_rea0.99279818
81MP0000751_myopathy0.98867258
82MP0002069_abnormal_eating/drinking_beha0.97767208
83MP0002161_abnormal_fertility/fecundity0.95932255
84MP0000343_altered_response_to0.92794383
85MP0004142_abnormal_muscle_tone0.92583905
86MP0006276_abnormal_autonomic_nervous0.91740483
87MP0000920_abnormal_myelination0.91644476
88MP0000604_amyloidosis0.90248245
89MP0005379_endocrine/exocrine_gland_phen0.89927331
90MP0005535_abnormal_body_temperature0.89034747
91MP0005666_abnormal_adipose_tissue0.88200512
92MP0009840_abnormal_foam_cell0.87918585
93MP0003191_abnormal_cellular_cholesterol0.87527302
94MP0004085_abnormal_heartbeat0.87209153
95MP0008260_abnormal_autophagy0.85819420
96MP0005409_darkened_coat_color0.85085934
97MP0002090_abnormal_vision0.84079085
98MP0001849_ear_inflammation0.83840616
99MP0002229_neurodegeneration0.82949454
100MP0005025_abnormal_response_to0.82818775
101MP0003634_abnormal_glial_cell0.80512338
102MP0005464_abnormal_platelet_physiology0.79536182
103MP0005000_abnormal_immune_tolerance0.75782236
104MP0009053_abnormal_anal_canal0.75168520
105MP0004185_abnormal_adipocyte_glucose0.74231138
106MP0005397_hematopoietic_system_phenotyp0.73353021
107MP0001545_abnormal_hematopoietic_system0.73353021
108MP0006082_CNS_inflammation0.73057691
109MP0003632_abnormal_nervous_system0.73006256
110MP0003705_abnormal_hypodermis_morpholog0.72890620
111MP0001188_hyperpigmentation0.72108554
112MP0005499_abnormal_olfactory_system0.70696945
113MP0005394_taste/olfaction_phenotype0.70696945
114MP0003172_abnormal_lysosome_physiology0.70620880
115MP0006292_abnormal_olfactory_placode0.70518445
116MP0004510_myositis0.69972726
117MP0003011_delayed_dark_adaptation0.69220526
118MP0001853_heart_inflammation0.69015386
119MP0005623_abnormal_meninges_morphology0.67372655
120MP0004947_skin_inflammation0.66583251
121MP0003122_maternal_imprinting0.66568009
122MP0005166_decreased_susceptibility_to0.66520220
123MP0005248_abnormal_Harderian_gland0.63938681
124MP0003137_abnormal_impulse_conducting0.61512628
125MP0001664_abnormal_digestion0.58449033
126MP0000631_abnormal_neuroendocrine_gland0.57006422
127MP0010386_abnormal_urinary_bladder0.56637978
128MP0001963_abnormal_hearing_physiology0.55649976
129MP0005551_abnormal_eye_electrophysiolog0.54943911
130MP0004130_abnormal_muscle_cell0.54324252
131MP0004742_abnormal_vestibular_system0.52673497
132MP0004043_abnormal_pH_regulation0.52627614
133MP0001485_abnormal_pinna_reflex0.51380572
134MP0002752_abnormal_somatic_nervous0.51163143
135MP0001943_abnormal_respiration0.50141530
136MP0004145_abnormal_muscle_electrophysio0.49313765
137MP0003956_abnormal_body_size0.48603236
138MP0004233_abnormal_muscle_weight0.48019087
139MP0010769_abnormal_survival0.47921666
140MP0003303_peritoneal_inflammation0.46841513
141MP0001299_abnormal_eye_distance/0.44600362
142MP0004484_altered_response_of0.44160859
143MP0010768_mortality/aging0.44159599

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.55709865
2Focal motor seizures (HP:0011153)7.38096317
3Focal seizures (HP:0007359)5.67435890
4Visual hallucinations (HP:0002367)5.17447809
5Action tremor (HP:0002345)4.34317030
6Abnormality of liposaccharide metabolism (HP:0010968)4.23020549
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.23020549
8Abnormality of glycolipid metabolism (HP:0010969)4.23020549
9Ankle clonus (HP:0011448)4.22285305
10Epileptic encephalopathy (HP:0200134)4.11420331
11Papilledema (HP:0001085)3.89592971
12Febrile seizures (HP:0002373)3.83829616
13Poor eye contact (HP:0000817)3.83155244
14Atonic seizures (HP:0010819)3.81570523
15Impaired vibration sensation in the lower limbs (HP:0002166)3.80235424
16Depression (HP:0000716)3.72429689
17Generalized tonic-clonic seizures (HP:0002069)3.71959779
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.67025917
19Severe visual impairment (HP:0001141)3.65468948
20Absence seizures (HP:0002121)3.65372113
21Supranuclear gaze palsy (HP:0000605)3.60443459
22Torticollis (HP:0000473)3.58407420
23Abnormal social behavior (HP:0012433)3.50062069
24Impaired social interactions (HP:0000735)3.50062069
25Urinary bladder sphincter dysfunction (HP:0002839)3.49828827
26Annular pancreas (HP:0001734)3.44768349
27Progressive cerebellar ataxia (HP:0002073)3.43321090
28Anxiety (HP:0000739)3.41609088
29Postural instability (HP:0002172)3.33691436
30Increased cerebral lipofuscin (HP:0011813)3.32773895
31Dialeptic seizures (HP:0011146)3.31587378
32Delusions (HP:0000746)3.27292449
33Broad-based gait (HP:0002136)3.27061426
34Dysdiadochokinesis (HP:0002075)3.25355173
35Upper motor neuron abnormality (HP:0002127)3.24081827
36Urinary urgency (HP:0000012)3.23918268
37Focal dystonia (HP:0004373)3.20991579
38Diminished motivation (HP:0000745)3.20380862
39Mutism (HP:0002300)3.18030323
40Axonal loss (HP:0003447)3.11096338
41Resting tremor (HP:0002322)3.10313181
42Abnormality of the lower motor neuron (HP:0002366)3.08406467
43Dysmetria (HP:0001310)3.07384641
44Gaze-evoked nystagmus (HP:0000640)3.03890451
45Abnormal eating behavior (HP:0100738)2.99696471
46Ventricular fibrillation (HP:0001663)2.97737418
47Craniofacial dystonia (HP:0012179)2.97519149
48Dysostosis multiplex (HP:0000943)2.97282805
49Hyperthyroidism (HP:0000836)2.93712869
50Personality changes (HP:0000751)2.88866725
51Spastic gait (HP:0002064)2.81594043
52Pointed chin (HP:0000307)2.80913459
53Intention tremor (HP:0002080)2.79979103
54Asymmetric septal hypertrophy (HP:0001670)2.76776899
55Megalencephaly (HP:0001355)2.74884541
56Nuclear cataract (HP:0100018)2.73755539
57Truncal ataxia (HP:0002078)2.73077639
58Stereotypic behavior (HP:0000733)2.73037106
59Hemiplegia (HP:0002301)2.70718603
60Bradykinesia (HP:0002067)2.69732571
61Increased neuronal autofluorescent lipopigment (HP:0002074)2.67354777
62Disinhibition (HP:0000734)2.67144888
63Amblyopia (HP:0000646)2.66482574
64Peripheral hypomyelination (HP:0007182)2.61889010
65Ankyloglossia (HP:0010296)2.61594129
66Aplasia/Hypoplasia of the sacrum (HP:0008517)2.60261373
67Bundle branch block (HP:0011710)2.59125925
68Impaired vibratory sensation (HP:0002495)2.58952212
69Impaired smooth pursuit (HP:0007772)2.58305466
70Obstructive lung disease (HP:0006536)2.53316682
71Chronic obstructive pulmonary disease (HP:0006510)2.53316682
72Dementia (HP:0000726)2.49396202
73Progressive inability to walk (HP:0002505)2.49253052
74Insomnia (HP:0100785)2.49050030
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.47741327
76Vacuolated lymphocytes (HP:0001922)2.43338566
77Genetic anticipation (HP:0003743)2.42132873
78Loss of speech (HP:0002371)2.41356989
79Neurofibrillary tangles (HP:0002185)2.40960253
80Scanning speech (HP:0002168)2.40388473
81Lower limb amyotrophy (HP:0007210)2.39533832
82Dysmetric saccades (HP:0000641)2.39431600
83Lower limb muscle weakness (HP:0007340)2.34040352
84Clonus (HP:0002169)2.33517503
85Obstructive sleep apnea (HP:0002870)2.31716915
86Hemiparesis (HP:0001269)2.31588420
87Abnormality of ocular smooth pursuit (HP:0000617)2.30145331
88Prolonged neonatal jaundice (HP:0006579)2.28487841
89Cerebral inclusion bodies (HP:0100314)2.27944724
90Male infertility (HP:0003251)2.24432008
91Termporal pattern (HP:0011008)2.22281280
92Insidious onset (HP:0003587)2.22281280
93Polyphagia (HP:0002591)2.21629215
94Abnormality of macrophages (HP:0004311)2.20446359
95Status epilepticus (HP:0002133)2.19661440
96Hand muscle atrophy (HP:0009130)2.17858577
97Hypertensive crisis (HP:0100735)2.16964399
98Nasal polyposis (HP:0100582)2.16015702
99Abnormal EKG (HP:0003115)2.14446814
100Abnormality of binocular vision (HP:0011514)2.13989524
101Diplopia (HP:0000651)2.13989524
102Broad distal phalanx of finger (HP:0009836)2.13746741
103Amyloidosis (HP:0011034)2.12436604
104Athetosis (HP:0002305)2.10727734
105Spastic tetraparesis (HP:0001285)2.09786789
106Incomplete penetrance (HP:0003829)2.09452481
107Recurrent abscess formation (HP:0002722)2.09129705
108Abnormality of the nasal mucosa (HP:0000433)2.08868681
109Cerebral hypomyelination (HP:0006808)2.07642741
110Fetal akinesia sequence (HP:0001989)2.06620834
111Excessive salivation (HP:0003781)2.05332525
112Drooling (HP:0002307)2.05332525
113Limb dystonia (HP:0002451)2.05209446
114Achilles tendon contracture (HP:0001771)2.04273867
115Hyperventilation (HP:0002883)2.02756952
116Neuronal loss in central nervous system (HP:0002529)2.01922177
117Abnormal large intestine physiology (HP:0012700)2.01570800
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00975877
119Apathy (HP:0000741)2.00838498
120Abnormality of the periventricular white matter (HP:0002518)1.98828889
121Hyperacusis (HP:0010780)1.98769130
122Bowel incontinence (HP:0002607)1.96298799
123Epileptiform EEG discharges (HP:0011182)1.95925905
124Lower limb asymmetry (HP:0100559)1.95922142
125EEG with generalized epileptiform discharges (HP:0011198)1.95764737
126Urinary incontinence (HP:0000020)1.94344570
127Hypsarrhythmia (HP:0002521)1.93605684
128Generalized myoclonic seizures (HP:0002123)1.93565436
129Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92739026
130Abnormality of polysaccharide metabolism (HP:0011012)1.92739026
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92739026
132Prolonged QT interval (HP:0001657)1.91894737
133Rigidity (HP:0002063)1.91820545
134Slow saccadic eye movements (HP:0000514)1.91529102
135Abnormality of oral frenula (HP:0000190)1.91294825
136Retinal atrophy (HP:0001105)1.91006572
137Absent/shortened dynein arms (HP:0200106)1.90170887
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.90170887
139Recurrent bacterial skin infections (HP:0005406)1.89831107
140Turricephaly (HP:0000262)1.88925919
141Abnormality of saccadic eye movements (HP:0000570)1.87275665
142Polygenic inheritance (HP:0010982)1.87133056
143Rapidly progressive (HP:0003678)1.87044645
144Abnormality of the corticospinal tract (HP:0002492)1.85901779
145Heart block (HP:0012722)1.85737040
146Hepatosplenomegaly (HP:0001433)1.85574702
147Gait ataxia (HP:0002066)1.84506010
148Spinal canal stenosis (HP:0003416)1.84215891
149Pheochromocytoma (HP:0002666)1.83819868
150Hypoplasia of the thymus (HP:0000778)1.82744847
151Tetraplegia (HP:0002445)1.82109605
152Truncus arteriosus (HP:0001660)1.82044009
153Ragged-red muscle fibers (HP:0003200)1.81660521
154Memory impairment (HP:0002354)1.80676944
155Inappropriate behavior (HP:0000719)1.80593364
156Neoplasm of the peripheral nervous system (HP:0100007)1.80541316
157Atelectasis (HP:0100750)1.79747474
158Neoplasm of the heart (HP:0100544)1.78616874
159Upper limb amyotrophy (HP:0009129)1.78297822
160Distal upper limb amyotrophy (HP:0007149)1.78297822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.69142166
2TESK14.23734086
3MAP3K94.21391007
4NTRK34.09663131
5DAPK23.19755685
6PRKD33.03579196
7KSR22.80587220
8MINK12.58232913
9NME22.57125212
10MAP3K112.55640900
11MARK12.51896251
12PAK62.44605818
13MAP3K42.42031021
14CAMKK12.35005503
15NTRK12.12093765
16TESK22.10047034
17NTRK21.96087644
18RIPK41.93833583
19IRAK31.82795338
20MAP2K71.79030007
21TAOK11.67776042
22DAPK11.66405255
23CDK51.65371559
24KSR11.62867197
25BRAF1.62448784
26TYRO31.57955153
27MAP3K131.56161647
28ARAF1.54838101
29STK381.53408592
30MAP3K21.53143446
31MAP2K41.50180206
32PLK41.48784637
33FES1.45309965
34SIK21.34005021
35PRPF4B1.25078076
36TAOK21.21922440
37CAMK1D1.17900974
38MAP3K121.17042900
39LIMK11.15040557
40ICK1.14556422
41GRK51.13412174
42ALK1.11638298
43PRKCH1.11500830
44PIM21.10130178
45UHMK11.07098281
46TNIK1.06056684
47ERN11.04545208
48PRKCG1.03826212
49RAF11.03420283
50PINK11.01508475
51CDK191.00556965
52STK110.99535055
53ABL20.98637420
54NEK10.96400822
55RET0.95485174
56CAMK10.94286198
57CAMKK20.92360056
58PLK20.92298098
59LATS20.91472990
60CDK150.90864738
61BRSK10.90555932
62CDK180.89852490
63LMTK20.87858597
64SGK4940.87058174
65SGK2230.87058174
66MAPK130.85903080
67CDK140.85097438
68RIPK10.83705646
69MAPK120.82391431
70PDK10.80300681
71CDK11A0.79386839
72SGK30.77915480
73TBK10.77227581
74PHKG10.77073506
75PHKG20.77073506
76PDPK10.76380714
77MAP3K10.76066148
78MAP2K30.75702008
79MARK20.73226943
80TNK20.72400567
81IRAK20.71740235
82CAMK2A0.70912798
83PTK2B0.70367579
84SGK10.67314392
85SGK20.67221266
86SCYL20.66567385
87AURKA0.64608586
88DAPK30.61645388
89BMPR20.60012171
90PAK30.59728001
91TRIB30.59249953
92SIK10.59152993
93STK160.57003071
94DYRK1B0.55448726
95RPS6KC10.55147234
96RPS6KL10.55147234
97MAP3K80.55141874
98PRKG20.53293295
99RPS6KA30.53076567
100MAP3K70.52818071
101PRKCZ0.51337681
102PKN10.50849694
103MAP2K10.50627248
104MAP2K20.50182463
105SMG10.49859363
106PAK10.49600048
107CAMK2B0.49236510
108MAP4K20.48832261
109CAMK40.48542034
110FYN0.47815284
111EEF2K0.47517896
112DMPK0.46779279
113NEK60.46381199
114CDC42BPA0.46227676
115PNCK0.44619128
116DYRK1A0.44236314
117MAPK100.44151639
118INSRR0.43387818
119CSNK1G20.42670790
120BLK0.38705202
121OXSR10.38515514
122RPS6KA60.38409240
123MAP2K60.37402282
124CDK70.37115917
125PRKD20.36790493
126RPS6KA20.35492173
127GRK60.33373881
128BMX0.32066338
129MOS0.32055631
130DDR20.30998731
131PDGFRA0.30194543
132PRKCB0.29867289
133CAMK2G0.29727520
134CAMK1G0.26705922
135PRKCE0.26271865
136WNK10.25582720
137MAPK80.24770212
138CASK0.24248256

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.26755272
2Synaptic vesicle cycle_Homo sapiens_hsa047213.20090600
3Nicotine addiction_Homo sapiens_hsa050332.94675536
4Circadian entrainment_Homo sapiens_hsa047132.64376709
5GABAergic synapse_Homo sapiens_hsa047272.60370901
6Long-term potentiation_Homo sapiens_hsa047202.54971290
7Morphine addiction_Homo sapiens_hsa050322.50361370
8Glutamatergic synapse_Homo sapiens_hsa047242.45709505
9Amphetamine addiction_Homo sapiens_hsa050312.43334587
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33101540
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20923304
12Dopaminergic synapse_Homo sapiens_hsa047282.16361814
13Salivary secretion_Homo sapiens_hsa049702.09648816
14Other glycan degradation_Homo sapiens_hsa005112.05159025
15Cholinergic synapse_Homo sapiens_hsa047252.04747498
16Nitrogen metabolism_Homo sapiens_hsa009102.03733040
17Gastric acid secretion_Homo sapiens_hsa049711.95982017
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.95455968
19Insulin secretion_Homo sapiens_hsa049111.94564632
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90425744
21Lysosome_Homo sapiens_hsa041421.89733988
22Cocaine addiction_Homo sapiens_hsa050301.88349550
23Vitamin B6 metabolism_Homo sapiens_hsa007501.83797076
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77301306
25Oxytocin signaling pathway_Homo sapiens_hsa049211.72627153
26Renin secretion_Homo sapiens_hsa049241.67952519
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.62868163
28GnRH signaling pathway_Homo sapiens_hsa049121.56509563
29Calcium signaling pathway_Homo sapiens_hsa040201.51441384
30Long-term depression_Homo sapiens_hsa047301.47300504
31Gap junction_Homo sapiens_hsa045401.44845125
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44798390
33Fatty acid biosynthesis_Homo sapiens_hsa000611.42112602
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.42085848
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41036625
36Serotonergic synapse_Homo sapiens_hsa047261.37372067
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35282947
38Glioma_Homo sapiens_hsa052141.32498777
39Taste transduction_Homo sapiens_hsa047421.32187235
40cAMP signaling pathway_Homo sapiens_hsa040241.28631382
41Sulfur relay system_Homo sapiens_hsa041221.22757574
42Type II diabetes mellitus_Homo sapiens_hsa049301.20809579
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18964607
44Osteoclast differentiation_Homo sapiens_hsa043801.18160952
45Estrogen signaling pathway_Homo sapiens_hsa049151.17221794
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12655350
47Tuberculosis_Homo sapiens_hsa051521.10258626
48ErbB signaling pathway_Homo sapiens_hsa040121.05149456
49Salmonella infection_Homo sapiens_hsa051321.02813993
50Melanogenesis_Homo sapiens_hsa049161.01469135
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01385855
52Pentose phosphate pathway_Homo sapiens_hsa000300.99130913
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.98014078
54B cell receptor signaling pathway_Homo sapiens_hsa046620.96094572
55Oocyte meiosis_Homo sapiens_hsa041140.95704050
56Dorso-ventral axis formation_Homo sapiens_hsa043200.95307917
57Collecting duct acid secretion_Homo sapiens_hsa049660.94347311
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93843959
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.93393759
60Axon guidance_Homo sapiens_hsa043600.93135826
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93110026
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91674519
63Phagosome_Homo sapiens_hsa041450.89278449
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84796474
65Allograft rejection_Homo sapiens_hsa053300.83096140
66VEGF signaling pathway_Homo sapiens_hsa043700.80858487
67Leishmaniasis_Homo sapiens_hsa051400.79883407
68Acute myeloid leukemia_Homo sapiens_hsa052210.79744140
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.79139591
70Rheumatoid arthritis_Homo sapiens_hsa053230.78002680
71Thyroid hormone synthesis_Homo sapiens_hsa049180.77204303
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76802948
73Antigen processing and presentation_Homo sapiens_hsa046120.75337681
74Pancreatic secretion_Homo sapiens_hsa049720.75333996
75Dilated cardiomyopathy_Homo sapiens_hsa054140.74683958
76Choline metabolism in cancer_Homo sapiens_hsa052310.72440223
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72367602
78MAPK signaling pathway_Homo sapiens_hsa040100.71743104
79Non-small cell lung cancer_Homo sapiens_hsa052230.71250374
80Cardiac muscle contraction_Homo sapiens_hsa042600.69639962
81Notch signaling pathway_Homo sapiens_hsa043300.69578009
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68935519
83mTOR signaling pathway_Homo sapiens_hsa041500.68619381
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68499991
85Rap1 signaling pathway_Homo sapiens_hsa040150.67571669
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67265367
87Biosynthesis of amino acids_Homo sapiens_hsa012300.66507137
88Type I diabetes mellitus_Homo sapiens_hsa049400.65898970
89Endocytosis_Homo sapiens_hsa041440.65455724
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62131933
91Bile secretion_Homo sapiens_hsa049760.61961382
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61190888
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.61108602
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.59978587
95Phototransduction_Homo sapiens_hsa047440.59706867
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.59143429
97Alcoholism_Homo sapiens_hsa050340.58926018
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58289286
99Autoimmune thyroid disease_Homo sapiens_hsa053200.58027629
100Ras signaling pathway_Homo sapiens_hsa040140.57501663
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.57252161
102Vibrio cholerae infection_Homo sapiens_hsa051100.57027691
103Endometrial cancer_Homo sapiens_hsa052130.56628180
104Shigellosis_Homo sapiens_hsa051310.56281646
105Glucagon signaling pathway_Homo sapiens_hsa049220.56033213
106Bladder cancer_Homo sapiens_hsa052190.55713884
107Graft-versus-host disease_Homo sapiens_hsa053320.53822770
108Chemokine signaling pathway_Homo sapiens_hsa040620.53545790
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52810328
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.52143112
111Prion diseases_Homo sapiens_hsa050200.50965562
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50618871
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50485601
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49233311
115Galactose metabolism_Homo sapiens_hsa000520.48336242
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47678877
117Insulin signaling pathway_Homo sapiens_hsa049100.47364553
118Inositol phosphate metabolism_Homo sapiens_hsa005620.47308854
119Pertussis_Homo sapiens_hsa051330.46964801
120Renal cell carcinoma_Homo sapiens_hsa052110.46847649
121Carbon metabolism_Homo sapiens_hsa012000.46748924
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45714912
123Viral myocarditis_Homo sapiens_hsa054160.45539135
124Legionellosis_Homo sapiens_hsa051340.44184278
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43012228
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40935921
127Ovarian steroidogenesis_Homo sapiens_hsa049130.40139407
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40006649
129Arginine biosynthesis_Homo sapiens_hsa002200.39383958
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38855858
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37595813
132Platelet activation_Homo sapiens_hsa046110.37395027
133Circadian rhythm_Homo sapiens_hsa047100.34649644
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33503867
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31754787
136Prolactin signaling pathway_Homo sapiens_hsa049170.31684194
137Wnt signaling pathway_Homo sapiens_hsa043100.29404007
138African trypanosomiasis_Homo sapiens_hsa051430.29311435

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