STK33P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)8.90386990
2establishment of protein localization to mitochondrial membrane (GO:0090151)6.78522549
3gamma-aminobutyric acid transport (GO:0015812)5.60550870
4cell proliferation in forebrain (GO:0021846)5.31864032
5cellular anion homeostasis (GO:0030002)4.99731885
6water-soluble vitamin biosynthetic process (GO:0042364)4.93718446
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.84652384
8tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.84652384
9tooth mineralization (GO:0034505)4.76931372
10epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.70305878
11cellular response to ATP (GO:0071318)4.65201744
12positive regulation of fatty acid oxidation (GO:0046321)4.62645196
13regulation of sequestering of triglyceride (GO:0010889)4.59987641
14negative regulation of response to food (GO:0032096)4.53243346
15negative regulation of appetite (GO:0032099)4.53243346
16homocysteine metabolic process (GO:0050667)4.47242460
17primary amino compound metabolic process (GO:1901160)4.40030618
18positive regulation of fatty acid beta-oxidation (GO:0032000)4.36057091
19negative regulation of transcription regulatory region DNA binding (GO:2000678)4.34338164
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.32309124
21otic vesicle formation (GO:0030916)4.20853090
22sulfation (GO:0051923)4.16516940
23regulation of glomerulus development (GO:0090192)4.07813632
24postsynaptic membrane organization (GO:0001941)4.01763923
25regulation of DNA endoreduplication (GO:0032875)3.93834637
26phosphate ion homeostasis (GO:0055062)3.89634378
27trivalent inorganic anion homeostasis (GO:0072506)3.89634378
28negative regulation of systemic arterial blood pressure (GO:0003085)3.74270998
29regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.74253990
30kynurenine metabolic process (GO:0070189)3.74066174
31white fat cell differentiation (GO:0050872)3.53705383
32transmission of nerve impulse (GO:0019226)3.53178174
33tryptophan catabolic process (GO:0006569)3.51365722
34indole-containing compound catabolic process (GO:0042436)3.51365722
35indolalkylamine catabolic process (GO:0046218)3.51365722
36inner ear receptor cell development (GO:0060119)3.42531581
37behavioral fear response (GO:0001662)3.42325769
38behavioral defense response (GO:0002209)3.42325769
39mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.35423220
40fear response (GO:0042596)3.34889952
41regulation of response to food (GO:0032095)3.33842167
42serotonin metabolic process (GO:0042428)3.33655825
43negative regulation of response to extracellular stimulus (GO:0032105)3.26773719
44negative regulation of response to nutrient levels (GO:0032108)3.26773719
45indole-containing compound metabolic process (GO:0042430)3.25690624
46indolalkylamine metabolic process (GO:0006586)3.16550389
47regulation of cell proliferation involved in kidney development (GO:1901722)3.12994380
48regulation of appetite (GO:0032098)3.12374419
49gonadal mesoderm development (GO:0007506)3.11706653
50vitamin catabolic process (GO:0009111)3.11270920
51fat-soluble vitamin catabolic process (GO:0042363)3.11270920
52somite development (GO:0061053)3.07960924
53regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.06445371
54regulation of cholesterol storage (GO:0010885)3.05540801
55membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.98897644
56protein complex biogenesis (GO:0070271)2.97778760
57positive regulation of metanephros development (GO:0072216)2.93159300
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92337037
59mitochondrial respiratory chain complex I assembly (GO:0032981)2.92337037
60NADH dehydrogenase complex assembly (GO:0010257)2.92337037
61chaperone-mediated protein transport (GO:0072321)2.89780810
62regulation of mesonephros development (GO:0061217)2.88172161
63protein polyglutamylation (GO:0018095)2.86564360
64regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85971279
65energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85853777
66ATP synthesis coupled proton transport (GO:0015986)2.85853777
67positive regulation of cardiac muscle cell differentiation (GO:2000727)2.83658711
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.82886313
69microtubule nucleation (GO:0007020)2.82267079
70alternative mRNA splicing, via spliceosome (GO:0000380)2.80756749
71cysteine metabolic process (GO:0006534)2.80522609
72serine family amino acid catabolic process (GO:0009071)2.80469617
73gamma-aminobutyric acid signaling pathway (GO:0007214)2.80204678
74parturition (GO:0007567)2.79898994
75negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.77139790
76membrane depolarization during action potential (GO:0086010)2.72923537
77negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.70701592
78regulation of transcription regulatory region DNA binding (GO:2000677)2.70016079
79positive regulation of cAMP-mediated signaling (GO:0043950)2.68914402
80galactose metabolic process (GO:0006012)2.68293206
81sulfur amino acid catabolic process (GO:0000098)2.65763500
82negative regulation of macrophage differentiation (GO:0045650)2.63035334
83tryptophan metabolic process (GO:0006568)2.62462840
84regulation of female receptivity (GO:0045924)2.61608341
85protein-cofactor linkage (GO:0018065)2.61338137
86opsonization (GO:0008228)2.60257554
87membrane repolarization during action potential (GO:0086011)2.59919679
88glyoxylate metabolic process (GO:0046487)2.59887306
89negative regulation of membrane potential (GO:0045837)2.59647770
90purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58802064
913-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58802064
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57509154
93positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.56321266
94regulation of plasminogen activation (GO:0010755)2.52158746
95mitochondrial respiratory chain complex assembly (GO:0033108)2.51078619
96positive regulation of mitochondrial fission (GO:0090141)2.50301879
97mesenchymal cell differentiation involved in renal system development (GO:2001012)2.49496351
98mesenchymal cell differentiation involved in kidney development (GO:0072161)2.49496351
99negative regulation of hormone biosynthetic process (GO:0032353)2.48883152
100mesenchymal to epithelial transition (GO:0060231)2.48510627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.79071985
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92615370
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.07595319
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78849459
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58919357
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.52940175
7BMI1_23680149_ChIP-Seq_NPCS_Mouse2.43899992
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39744855
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38780932
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35189908
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.28955089
12RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.28611071
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.27299880
14VDR_22108803_ChIP-Seq_LS180_Human2.26731208
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18672745
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.09975762
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.03723051
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99062287
19GBX2_23144817_ChIP-Seq_PC3_Human1.96995293
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85268559
21IRF1_19129219_ChIP-ChIP_H3396_Human1.80367848
22RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.78694575
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.77006815
24REST_21632747_ChIP-Seq_MESCs_Mouse1.76351482
25ZNF274_21170338_ChIP-Seq_K562_Hela1.75978263
26RNF2_27304074_Chip-Seq_NSC_Mouse1.73432041
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.72844281
28SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71666556
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70952332
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70952332
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69901761
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62344031
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.58160646
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.57662725
35EWS_26573619_Chip-Seq_HEK293_Human1.57335081
36FUS_26573619_Chip-Seq_HEK293_Human1.54562598
37SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51206420
38TDRD3_21172665_ChIP-Seq_MCF-7_Human1.50903552
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.49475271
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47581103
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.41732997
42SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40565323
43NCOR_22424771_ChIP-Seq_293T_Human1.40101426
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.39022741
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38603998
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37754646
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36031079
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33814190
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33250500
50BCAT_22108803_ChIP-Seq_LS180_Human1.32101162
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30421152
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30037291
53TP53_22573176_ChIP-Seq_HFKS_Human1.28297388
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26716419
55CBP_20019798_ChIP-Seq_JUKART_Human1.26716419
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25186234
57AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24388406
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22694996
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.22386441
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.21603575
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21105868
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20422864
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.16672024
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14701043
65IGF1R_20145208_ChIP-Seq_DFB_Human1.11035960
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10310991
67P300_19829295_ChIP-Seq_ESCs_Human1.09904332
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07181950
69STAT3_23295773_ChIP-Seq_U87_Human1.04996296
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.03175724
71FOXH1_21741376_ChIP-Seq_ESCs_Human1.02488174
72MYC_18940864_ChIP-ChIP_HL60_Human1.01495591
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98866541
74MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97307244
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96942059
76NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96415482
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96132793
78TAL1_26923725_Chip-Seq_HPCs_Mouse0.95722825
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94511075
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94472748
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91073531
82HOXB7_26014856_ChIP-Seq_BT474_Human0.90620795
83GATA3_21878914_ChIP-Seq_MCF-7_Human0.90616627
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89570032
85TCF4_23295773_ChIP-Seq_U87_Human0.89522788
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.89409750
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89205159
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.89151749
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89151749
90SMAD3_21741376_ChIP-Seq_ESCs_Human0.88083663
91TAF2_19829295_ChIP-Seq_ESCs_Human0.87838490
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86074399
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86067092
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85824507
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84939844
96TCF4_22108803_ChIP-Seq_LS180_Human0.84075371
97FLI1_21867929_ChIP-Seq_TH2_Mouse0.84072949
98MYC_19829295_ChIP-Seq_ESCs_Human0.83739086
99NANOG_20526341_ChIP-Seq_ESCs_Human0.83094304
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.83043354

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.22765600
2MP0003646_muscle_fatigue3.68458235
3MP0006292_abnormal_olfactory_placode3.33646812
4MP0002160_abnormal_reproductive_system2.94254559
5MP0004130_abnormal_muscle_cell2.91958816
6MP0005646_abnormal_pituitary_gland2.76618600
7MP0004885_abnormal_endolymph2.71866149
8MP0004145_abnormal_muscle_electrophysio2.52992072
9MP0004142_abnormal_muscle_tone2.47411365
10MP0001485_abnormal_pinna_reflex2.30420324
11MP0004134_abnormal_chest_morphology2.18631515
12MP0002736_abnormal_nociception_after2.08820164
13MP0001440_abnormal_grooming_behavior2.08597036
14MP0002653_abnormal_ependyma_morphology2.00524696
15MP0001968_abnormal_touch/_nociception1.96472181
16MP0005389_reproductive_system_phenotype1.94637943
17MP0008872_abnormal_physiological_respon1.91275666
18MP0000631_abnormal_neuroendocrine_gland1.90721597
19MP0003879_abnormal_hair_cell1.89918204
20MP0005551_abnormal_eye_electrophysiolog1.89772408
21MP0002272_abnormal_nervous_system1.87297555
22MP0004133_heterotaxia1.86770347
23MP0004147_increased_porphyrin_level1.81275215
24MP0005670_abnormal_white_adipose1.73068877
25MP0002733_abnormal_thermal_nociception1.68028089
26MP0000049_abnormal_middle_ear1.62943536
27MP0003942_abnormal_urinary_system1.62385439
28MP0003011_delayed_dark_adaptation1.61459251
29MP0002734_abnormal_mechanical_nocicepti1.60257293
30MP0009745_abnormal_behavioral_response1.59020828
31MP0003122_maternal_imprinting1.57230486
32MP0002735_abnormal_chemical_nociception1.53617226
33MP0002089_abnormal_postnatal_growth/wei1.53038418
34MP0001853_heart_inflammation1.50871480
35MP0002184_abnormal_innervation1.50767631
36MP0002938_white_spotting1.50091924
37MP0002638_abnormal_pupillary_reflex1.43566057
38MP0005360_urolithiasis1.43291066
39MP0000026_abnormal_inner_ear1.43077050
40MP0000778_abnormal_nervous_system1.40965392
41MP0009250_abnormal_appendicular_skeleto1.40729854
42MP0009379_abnormal_foot_pigmentation1.38627075
43MP0003878_abnormal_ear_physiology1.36788005
44MP0005377_hearing/vestibular/ear_phenot1.36788005
45MP0000534_abnormal_ureter_morphology1.36614157
46MP0004742_abnormal_vestibular_system1.35217663
47MP0009046_muscle_twitch1.33984868
48MP0001542_abnormal_bone_strength1.33459663
49MP0001486_abnormal_startle_reflex1.32232260
50MP0008789_abnormal_olfactory_epithelium1.31103441
51MP0001963_abnormal_hearing_physiology1.28309586
52MP0000678_abnormal_parathyroid_gland1.28289455
53MP0001970_abnormal_pain_threshold1.26513856
54MP0003183_abnormal_peptide_metabolism1.23228879
55MP0006276_abnormal_autonomic_nervous1.22162780
56MP0002064_seizures1.21514451
57MP0008775_abnormal_heart_ventricle1.19708096
58MP0003638_abnormal_response/metabolism_1.19128765
59MP0001919_abnormal_reproductive_system1.19055409
60MP0002063_abnormal_learning/memory/cond1.15268496
61MP0004270_analgesia1.14904365
62MP0003635_abnormal_synaptic_transmissio1.13255267
63MP0006072_abnormal_retinal_apoptosis1.12600902
64MP0003938_abnormal_ear_development1.10215497
65MP0008995_early_reproductive_senescence1.08674972
66MP0002752_abnormal_somatic_nervous1.08556404
67MP0005423_abnormal_somatic_nervous1.00776771
68MP0005195_abnormal_posterior_eye0.97019824
69MP0003121_genomic_imprinting0.94367462
70MP0002557_abnormal_social/conspecific_i0.94005127
71MP0000537_abnormal_urethra_morphology0.92552386
72MP0004019_abnormal_vitamin_homeostasis0.92200925
73MP0005253_abnormal_eye_physiology0.90149794
74MP0001293_anophthalmia0.89967411
75MP0009053_abnormal_anal_canal0.88563167
76MP0002876_abnormal_thyroid_physiology0.88257944
77MP0004215_abnormal_myocardial_fiber0.87943111
78MP0002138_abnormal_hepatobiliary_system0.87370728
79MP0004185_abnormal_adipocyte_glucose0.86687455
80MP0010386_abnormal_urinary_bladder0.86584935
81MP0002163_abnormal_gland_morphology0.86084902
82MP0005332_abnormal_amino_acid0.85433123
83MP0002095_abnormal_skin_pigmentation0.84742252
84MP0003937_abnormal_limbs/digits/tail_de0.83495390
85MP0003787_abnormal_imprinting0.82046183
86MP0000955_abnormal_spinal_cord0.82032247
87MP0003186_abnormal_redox_activity0.79450027
88MP0009765_abnormal_xenobiotic_induced0.78016082
89MP0002067_abnormal_sensory_capabilities0.77141247
90MP0001502_abnormal_circadian_rhythm0.75699397
91MP0001905_abnormal_dopamine_level0.74586132
92MP0005499_abnormal_olfactory_system0.72396597
93MP0005394_taste/olfaction_phenotype0.72396597
94MP0002249_abnormal_larynx_morphology0.72037520
95MP0002229_neurodegeneration0.71241146
96MP0008569_lethality_at_weaning0.71179651
97MP0003195_calcinosis0.70953307
98MP0008877_abnormal_DNA_methylation0.70361384
99MP0003880_abnormal_central_pattern0.69026411
100MP0002882_abnormal_neuron_morphology0.68588540

Predicted human phenotypes

RankGene SetZ-score
1Pendular nystagmus (HP:0012043)4.42961669
2Abnormality of alanine metabolism (HP:0010916)4.33999569
3Hyperalaninemia (HP:0003348)4.33999569
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.33999569
5Progressive cerebellar ataxia (HP:0002073)4.25058611
6Congenital sensorineural hearing impairment (HP:0008527)3.96167135
7True hermaphroditism (HP:0010459)3.83577004
8Genetic anticipation (HP:0003743)3.67977223
9Pancreatic fibrosis (HP:0100732)3.66270430
10Absent rod-and cone-mediated responses on ERG (HP:0007688)3.57239159
11Abnormality of homocysteine metabolism (HP:0010919)3.51440042
12Homocystinuria (HP:0002156)3.51440042
13Chronic hepatic failure (HP:0100626)3.49455311
14Agitation (HP:0000713)3.38998852
15Abnormality of cochlea (HP:0000375)3.30783831
163-Methylglutaconic aciduria (HP:0003535)3.28981243
17Septo-optic dysplasia (HP:0100842)3.12412217
18Abolished electroretinogram (ERG) (HP:0000550)3.04378639
19Pancreatic cysts (HP:0001737)3.03135976
20Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.86778906
21Methylmalonic acidemia (HP:0002912)2.86610478
22Stenosis of the external auditory canal (HP:0000402)2.85295187
23Visual hallucinations (HP:0002367)2.78029240
24Porencephaly (HP:0002132)2.76719050
25Molar tooth sign on MRI (HP:0002419)2.74065198
26Abnormality of midbrain morphology (HP:0002418)2.74065198
27Reticulocytopenia (HP:0001896)2.72307310
28Action tremor (HP:0002345)2.70559172
29Asplenia (HP:0001746)2.69845162
30Aplasia/Hypoplasia of the spleen (HP:0010451)2.68950898
31Abnormal rod and cone electroretinograms (HP:0008323)2.65776593
32Nephronophthisis (HP:0000090)2.65222398
33Abnormality of the phalanges of the 5th finger (HP:0004213)2.65099722
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.55341600
35Osteomalacia (HP:0002749)2.55010848
36Short tibia (HP:0005736)2.48930454
37Morphological abnormality of the inner ear (HP:0011390)2.47211953
38Keratoconus (HP:0000563)2.45751022
39Increased corneal curvature (HP:0100692)2.45751022
40Confusion (HP:0001289)2.45705938
41Sclerocornea (HP:0000647)2.44275191
42Anencephaly (HP:0002323)2.43768259
43Optic nerve hypoplasia (HP:0000609)2.43697994
44Hemiparesis (HP:0001269)2.43453664
45Abnormality of the nasal septum (HP:0000419)2.39635625
46Absent thumb (HP:0009777)2.37762028
47Ectopic kidney (HP:0000086)2.35667792
48Male pseudohermaphroditism (HP:0000037)2.35655983
49Pigmentary retinal degeneration (HP:0001146)2.32596203
50Chorioretinal atrophy (HP:0000533)2.32209319
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.31791742
52Short femoral neck (HP:0100864)2.30514283
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.30499798
54Abnormality of the renal collecting system (HP:0004742)2.27844742
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.27582870
56Abnormality of the proximal phalanges of the hand (HP:0009834)2.27144875
57Methylmalonic aciduria (HP:0012120)2.26212199
58Abnormality of binocular vision (HP:0011514)2.25030441
59Diplopia (HP:0000651)2.25030441
60Abnormality of cells of the erythroid lineage (HP:0012130)2.20075467
61Cystic liver disease (HP:0006706)2.19913109
62Oligomenorrhea (HP:0000876)2.17363363
63Maternal diabetes (HP:0009800)2.14738911
64Constricted visual fields (HP:0001133)2.13031858
65Abnormality of serum amino acid levels (HP:0003112)2.12586890
66Myotonia (HP:0002486)2.09270173
67Absent septum pellucidum (HP:0001331)2.08418499
68Severe visual impairment (HP:0001141)2.08172631
69Abnormality of the middle phalanges of the toes (HP:0010183)2.05889028
70Congenital stationary night blindness (HP:0007642)2.03265988
71Elevated erythrocyte sedimentation rate (HP:0003565)2.01552638
72Symphalangism affecting the phalanges of the hand (HP:0009773)2.00701219
73Abnormality of renal resorption (HP:0011038)1.99280806
74Long nose (HP:0003189)1.97685130
75Decreased central vision (HP:0007663)1.95444747
76Abnormality of the renal medulla (HP:0100957)1.95035785
77Abnormality of DNA repair (HP:0003254)1.94663683
78Attenuation of retinal blood vessels (HP:0007843)1.94244374
79Hemiplegia (HP:0002301)1.91771557
80Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.91362657
81Short 4th metacarpal (HP:0010044)1.91362657
82Furrowed tongue (HP:0000221)1.90793056
83Fibular hypoplasia (HP:0003038)1.88463129
84Morphological abnormality of the middle ear (HP:0008609)1.87305580
85Short 1st metacarpal (HP:0010034)1.86928175
86Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.86928175
87Abnormality of sulfur amino acid metabolism (HP:0004339)1.86759098
88Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84576588
89Abnormality of the corticospinal tract (HP:0002492)1.81049628
90Goiter (HP:0000853)1.81038698
91Aplasia/Hypoplasia of the fibula (HP:0006492)1.80293656
92Abnormality of the phalanges of the 2nd finger (HP:0009541)1.79758496
93Bony spicule pigmentary retinopathy (HP:0007737)1.79693689
94Hypoplasia of the uterus (HP:0000013)1.79063846
95Decreased circulating renin level (HP:0003351)1.76135668
96Mesomelia (HP:0003027)1.76035314
97Abnormal number of erythroid precursors (HP:0012131)1.74390584
98Aplasia/Hypoplasia of the uvula (HP:0010293)1.72725544
99Abnormality of the 4th metacarpal (HP:0010012)1.70952832
100Abnormality of the labia minora (HP:0012880)1.70136735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.88405660
2ADRBK22.69999259
3GRK12.69767769
4MUSK2.56124121
5PINK12.51677637
6DYRK32.49511103
7WNK42.42066608
8DYRK22.40729947
9SGK4942.30215462
10SGK2232.30215462
11NTRK22.04025125
12SGK21.97241266
13PRKD21.94832893
14FRK1.89623329
15MAP3K111.85523179
16SIK21.74330155
17MAP4K21.71079289
18EPHB21.65593390
19TXK1.64829749
20VRK11.59675687
21TNIK1.58663226
22DAPK21.58015131
23PIK3CA1.55013388
24ACVR1B1.54334578
25SGK31.45537131
26MAP3K31.44401179
27WNK31.41605325
28RPS6KA21.35422163
29MAP3K121.29894545
30TYRO31.27688524
31AKT31.19280812
32RPS6KA61.16855689
33SGK11.15402813
34PRKCG1.12790190
35EPHA31.12327486
36CASK1.09337203
37RPS6KL11.04212983
38RPS6KC11.04212983
39RPS6KA41.02994938
40ADRBK11.00784996
41EPHA40.99044471
42ERBB20.96940710
43PRKCE0.96266042
44DYRK1B0.95221246
45GRK70.94189780
46CDC70.92649664
47PAK30.92010616
48NUAK10.90933623
49MAP3K40.90497049
50PHKG10.90443718
51PHKG20.90443718
52CSNK1A10.88541139
53HIPK20.87612817
54TAF10.83612976
55MAP2K70.83201748
56PLK20.82053890
57STK390.79546379
58VRK20.76175574
59MINK10.76153413
60CAMK10.76121617
61MARK10.75759229
62AURKA0.75256023
63PRKCI0.72481251
64CDK50.70303925
65MAP2K30.69884770
66NTRK30.68835942
67PRKACA0.67999509
68CAMKK20.67490645
69PKN10.66781915
70IRAK40.65279803
71PRKD10.65108248
72RPS6KA50.64909903
73MAPK130.61058034
74NLK0.58724883
75PRKCH0.54834900
76PRKCD0.54610878
77DYRK1A0.53767491
78ATR0.52121023
79INSRR0.51488927
80CAMK2A0.49772414
81TIE10.48476132
82PRKCA0.47948496
83TLK10.45644640
84GRK50.43807127
85PRKCQ0.43741216
86GRK60.43268358
87CDK90.42911169
88BCKDK0.42628574
89PRKCZ0.42009962
90RPS6KA10.41022080
91CSNK2A10.40310296
92NME10.39751659
93PNCK0.37494268
94BMPR1B0.34994228
95STK38L0.34757488
96MAP4K10.34245779
97BLK0.33892982
98DAPK30.33395540
99BRAF0.32812547
100CAMK40.32724291

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.54926391
2Oxidative phosphorylation_Homo sapiens_hsa001903.45347381
3Parkinsons disease_Homo sapiens_hsa050122.62880372
4Cardiac muscle contraction_Homo sapiens_hsa042602.44096942
5Morphine addiction_Homo sapiens_hsa050322.41314063
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.21387705
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.17974648
8Alzheimers disease_Homo sapiens_hsa050102.16601375
9Phototransduction_Homo sapiens_hsa047442.13178286
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04539678
11GABAergic synapse_Homo sapiens_hsa047271.99452423
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95878876
13Collecting duct acid secretion_Homo sapiens_hsa049661.90317531
14Homologous recombination_Homo sapiens_hsa034401.86838109
15Huntingtons disease_Homo sapiens_hsa050161.86094282
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.77196049
17Glutamatergic synapse_Homo sapiens_hsa047241.75867261
18Selenocompound metabolism_Homo sapiens_hsa004501.65962845
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64165249
20Basal transcription factors_Homo sapiens_hsa030221.63987219
21Vitamin digestion and absorption_Homo sapiens_hsa049771.60352804
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.57671124
23Ribosome_Homo sapiens_hsa030101.55833724
24One carbon pool by folate_Homo sapiens_hsa006701.48815842
25Serotonergic synapse_Homo sapiens_hsa047261.47414755
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.45919413
27Synaptic vesicle cycle_Homo sapiens_hsa047211.45376329
28Protein export_Homo sapiens_hsa030601.42794737
29Olfactory transduction_Homo sapiens_hsa047401.41845260
30Linoleic acid metabolism_Homo sapiens_hsa005911.40539774
31Chemical carcinogenesis_Homo sapiens_hsa052041.39589121
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38113986
33Fanconi anemia pathway_Homo sapiens_hsa034601.37329531
34Nitrogen metabolism_Homo sapiens_hsa009101.36694024
35Tryptophan metabolism_Homo sapiens_hsa003801.34835563
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34590119
37Cholinergic synapse_Homo sapiens_hsa047251.31447467
38Sulfur metabolism_Homo sapiens_hsa009201.28433497
39Sulfur relay system_Homo sapiens_hsa041221.28003752
40RNA polymerase_Homo sapiens_hsa030201.26001609
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25021965
42Circadian entrainment_Homo sapiens_hsa047131.23953993
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.23603944
44Galactose metabolism_Homo sapiens_hsa000521.17285793
45Dopaminergic synapse_Homo sapiens_hsa047281.15106097
46Taste transduction_Homo sapiens_hsa047421.13619498
47Melanoma_Homo sapiens_hsa052181.12366640
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.05029764
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02252123
50Peroxisome_Homo sapiens_hsa041461.01695723
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01499561
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00808084
53Retinol metabolism_Homo sapiens_hsa008300.96492348
54RNA degradation_Homo sapiens_hsa030180.96381927
55Primary immunodeficiency_Homo sapiens_hsa053400.93693187
56Fat digestion and absorption_Homo sapiens_hsa049750.93684529
57Insulin secretion_Homo sapiens_hsa049110.90390344
58DNA replication_Homo sapiens_hsa030300.90220729
59Cocaine addiction_Homo sapiens_hsa050300.87798101
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86094170
61Fatty acid biosynthesis_Homo sapiens_hsa000610.82520059
62Glycerolipid metabolism_Homo sapiens_hsa005610.80985620
63Steroid biosynthesis_Homo sapiens_hsa001000.78277712
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77830250
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76359328
66Butanoate metabolism_Homo sapiens_hsa006500.74969526
67Type II diabetes mellitus_Homo sapiens_hsa049300.70064009
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.65161470
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64608056
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63424665
71Nucleotide excision repair_Homo sapiens_hsa034200.62443344
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60114828
73Antigen processing and presentation_Homo sapiens_hsa046120.58525168
74Regulation of autophagy_Homo sapiens_hsa041400.58333330
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.57368836
76Ether lipid metabolism_Homo sapiens_hsa005650.56726728
77Hedgehog signaling pathway_Homo sapiens_hsa043400.56103389
78Metabolic pathways_Homo sapiens_hsa011000.54483144
79Ras signaling pathway_Homo sapiens_hsa040140.52304556
80Caffeine metabolism_Homo sapiens_hsa002320.51833165
81PPAR signaling pathway_Homo sapiens_hsa033200.51389819
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51377966
83Calcium signaling pathway_Homo sapiens_hsa040200.48548365
84Glutathione metabolism_Homo sapiens_hsa004800.47505129
85cAMP signaling pathway_Homo sapiens_hsa040240.43681943
86Amphetamine addiction_Homo sapiens_hsa050310.41169422
87Proteasome_Homo sapiens_hsa030500.39718292
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.39041505
89Alcoholism_Homo sapiens_hsa050340.39011839
90Basal cell carcinoma_Homo sapiens_hsa052170.38705273
91Renin secretion_Homo sapiens_hsa049240.37329442
92Axon guidance_Homo sapiens_hsa043600.36206139
93MAPK signaling pathway_Homo sapiens_hsa040100.33611304
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.33490200
95Systemic lupus erythematosus_Homo sapiens_hsa053220.33022495
96Arginine and proline metabolism_Homo sapiens_hsa003300.32048095
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30859196
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28507929
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24426422
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.22987219

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