STK35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a kinase that is predominantly found in the nucleus. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. The encoded protein may be a regulator of actin stress fibers in nonmuscle cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1retinal cone cell development (GO:0046549)9.69062585
2detection of light stimulus involved in sensory perception (GO:0050962)8.84350680
3detection of light stimulus involved in visual perception (GO:0050908)8.84350680
4photoreceptor cell maintenance (GO:0045494)8.03193034
5photoreceptor cell development (GO:0042461)7.49831492
6protein-chromophore linkage (GO:0018298)7.35617913
7retinal rod cell development (GO:0046548)7.31284657
8eye photoreceptor cell development (GO:0042462)7.09576154
9phototransduction, visible light (GO:0007603)6.99263243
10detection of visible light (GO:0009584)6.79519663
11phototransduction (GO:0007602)6.71950866
12detection of light stimulus (GO:0009583)6.51997582
13GMP metabolic process (GO:0046037)5.85652100
14visual perception (GO:0007601)5.75934568
15sensory perception of light stimulus (GO:0050953)5.69678044
16cellular response to light stimulus (GO:0071482)5.66244751
17positive regulation of guanylate cyclase activity (GO:0031284)5.47272996
18regulation of guanylate cyclase activity (GO:0031282)4.88050588
19retina development in camera-type eye (GO:0060041)4.67484344
20detection of external stimulus (GO:0009581)4.52483192
21detection of abiotic stimulus (GO:0009582)4.44305438
22regulation of cholesterol homeostasis (GO:2000188)4.11297011
23regulation of clathrin-mediated endocytosis (GO:2000369)3.91723325
24photoreceptor cell differentiation (GO:0046530)3.91444638
25eye photoreceptor cell differentiation (GO:0001754)3.91444638
26protein complex localization (GO:0031503)3.87928451
27cellular response to radiation (GO:0071478)3.78831303
28cellular protein complex localization (GO:0034629)3.76525691
29regulation of cGMP metabolic process (GO:0030823)3.75939615
30piRNA metabolic process (GO:0034587)3.68300837
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61860106
32DNA unwinding involved in DNA replication (GO:0006268)3.55193127
33positive regulation of cGMP biosynthetic process (GO:0030828)3.54291880
34mitotic sister chromatid cohesion (GO:0007064)3.53079212
35pre-miRNA processing (GO:0031054)3.46153605
36CDP-diacylglycerol biosynthetic process (GO:0016024)3.37876796
37adherens junction assembly (GO:0034333)3.36942293
38nuclear pore complex assembly (GO:0051292)3.34638690
39cell-substrate adherens junction assembly (GO:0007045)3.33304959
40focal adhesion assembly (GO:0048041)3.33304959
41regulation of mammary gland epithelial cell proliferation (GO:0033599)3.32584283
42regulation of NFAT protein import into nucleus (GO:0051532)3.29362956
43regulation of cGMP biosynthetic process (GO:0030826)3.28821582
44mRNA stabilization (GO:0048255)3.25090801
45RNA stabilization (GO:0043489)3.25090801
46planar cell polarity pathway involved in neural tube closure (GO:0090179)3.21160483
47synaptonemal complex assembly (GO:0007130)3.18559304
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.17822691
49lung epithelium development (GO:0060428)3.14908761
50positive regulation of cGMP metabolic process (GO:0030825)3.14779297
51CDP-diacylglycerol metabolic process (GO:0046341)3.13867637
52adaptation of signaling pathway (GO:0023058)3.12799795
53nuclear pore organization (GO:0006999)3.12676867
54cellular response to epidermal growth factor stimulus (GO:0071364)3.11953237
55regulation of nucleobase-containing compound transport (GO:0032239)3.10612058
56histone H3-K36 demethylation (GO:0070544)3.10464460
57regulation of chromatin binding (GO:0035561)3.09289077
58embryonic process involved in female pregnancy (GO:0060136)3.07867427
59receptor guanylyl cyclase signaling pathway (GO:0007168)3.05605977
60gene silencing by RNA (GO:0031047)3.04784633
61maternal placenta development (GO:0001893)3.01254747
62protein export from nucleus (GO:0006611)3.00781768
63nonmotile primary cilium assembly (GO:0035058)2.99836493
64regulation of translational fidelity (GO:0006450)2.99259781
65positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.98605351
66positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.98605351
67positive regulation of mitotic sister chromatid separation (GO:1901970)2.98605351
68motile cilium assembly (GO:0044458)2.94701508
69COPI coating of Golgi vesicle (GO:0048205)2.94599196
70Golgi transport vesicle coating (GO:0048200)2.94599196
71sodium ion export (GO:0071436)2.94061716
72regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.93613778
73regulation of posttranscriptional gene silencing (GO:0060147)2.92856151
74regulation of gene silencing by miRNA (GO:0060964)2.92856151
75regulation of gene silencing by RNA (GO:0060966)2.92856151
76synaptonemal complex organization (GO:0070193)2.92575580
77regulation of bile acid biosynthetic process (GO:0070857)2.90963905
78activation of Rac GTPase activity (GO:0032863)2.88931078
79paraxial mesoderm development (GO:0048339)2.88859581
80protein-DNA complex disassembly (GO:0032986)2.87734568
81nucleosome disassembly (GO:0006337)2.87734568
82regulation of RNA export from nucleus (GO:0046831)2.87015416
83male meiosis (GO:0007140)2.85192418
84notochord development (GO:0030903)2.85160971
85apoptotic process involved in morphogenesis (GO:0060561)2.85146083
86cytoplasmic mRNA processing body assembly (GO:0033962)2.83930458
87regulation of protein polyubiquitination (GO:1902914)2.83614435
88macroautophagy (GO:0016236)2.83367011
89gene silencing (GO:0016458)2.82733537
90cell-cell junction maintenance (GO:0045217)2.82211346
91chromosome condensation (GO:0030261)2.78005610
92response to light stimulus (GO:0009416)2.77253223
93response to epidermal growth factor (GO:0070849)2.76486040
94cellular hyperosmotic response (GO:0071474)2.76318547
95glomerular basement membrane development (GO:0032836)2.74474952
96regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.73877654
97positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.73877654
98desmosome organization (GO:0002934)2.73297132
99establishment of apical/basal cell polarity (GO:0035089)2.71298393
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.71140058
101positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.70443603
102monoubiquitinated protein deubiquitination (GO:0035520)2.65765192
103positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.65523704
104histone H3-K9 demethylation (GO:0033169)2.65306558
105cytoskeletal anchoring at plasma membrane (GO:0007016)2.65129973
106regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.63342990
107negative regulation of histone methylation (GO:0031061)2.63087638
108convergent extension (GO:0060026)2.62734558
109proline biosynthetic process (GO:0006561)2.62427706
110regulation of sister chromatid cohesion (GO:0007063)2.62346418
111plasma lipoprotein particle assembly (GO:0034377)2.61648237
112histone H2A monoubiquitination (GO:0035518)2.61279419
113retina layer formation (GO:0010842)2.60971984
114sperm motility (GO:0030317)2.60196970
115regulation of cilium movement (GO:0003352)2.60039247
116regulation of stem cell maintenance (GO:2000036)2.58849620
117detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.57792721
118protein localization to chromosome, centromeric region (GO:0071459)2.54784688
119peptidyl-lysine dimethylation (GO:0018027)2.53878673
120positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.53789385
121embryonic retina morphogenesis in camera-type eye (GO:0060059)2.53494176
122trophectodermal cell differentiation (GO:0001829)2.53472972
123L-alpha-amino acid transmembrane transport (GO:1902475)2.52992639
124chromatin silencing (GO:0006342)2.52429927
125regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.51779694
126regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.51368489
127histone H3-K4 methylation (GO:0051568)2.50521001
128cell-substrate junction assembly (GO:0007044)2.49963956
129glucose 6-phosphate metabolic process (GO:0051156)2.49489688
130hippo signaling (GO:0035329)2.48979875
131regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.48639138
132histone demethylation (GO:0016577)2.48418017
133regulation of meiosis I (GO:0060631)2.48267435
134epithelial cell-cell adhesion (GO:0090136)2.47812979
135mitotic nuclear envelope disassembly (GO:0007077)2.47235814
136stress granule assembly (GO:0034063)2.46595650
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45871992
138embryonic camera-type eye development (GO:0031076)2.45789501
139positive regulation of chromosome segregation (GO:0051984)2.45525643
140bundle of His cell to Purkinje myocyte communication (GO:0086069)2.45098140
141mitotic sister chromatid segregation (GO:0000070)2.44613940
142embryonic placenta development (GO:0001892)2.43683646
143sister chromatid segregation (GO:0000819)2.43546335
144sensory perception (GO:0007600)2.43413523
145heterochromatin organization (GO:0070828)2.43166951
146DNA packaging (GO:0006323)2.42681601
147protein localization to kinetochore (GO:0034501)2.42107179
148positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.41224817
149histone H3-K9 methylation (GO:0051567)2.40559179
150regulation of mRNA stability (GO:0043488)2.40434861
151regulation of DNA damage checkpoint (GO:2000001)2.39948524
152positive regulation of gene expression, epigenetic (GO:0045815)2.39928554
1533-UTR-mediated mRNA stabilization (GO:0070935)2.39314501
154negative regulation of viral release from host cell (GO:1902187)2.38883704
155negative regulation of mRNA metabolic process (GO:1903312)2.38569097
156branching involved in mammary gland duct morphogenesis (GO:0060444)2.37511006
157positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.37468165
158regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.37468165
159intracellular estrogen receptor signaling pathway (GO:0030520)2.37221015
160mitotic chromosome condensation (GO:0007076)2.37204120
161lipid translocation (GO:0034204)2.36837085
162phospholipid translocation (GO:0045332)2.36837085
163pore complex assembly (GO:0046931)2.36423358
164DNA duplex unwinding (GO:0032508)2.36035964
165retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.35854491
166receptor recycling (GO:0001881)2.35841715
167positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35641868
168NLS-bearing protein import into nucleus (GO:0006607)2.35486502
1694-hydroxyproline metabolic process (GO:0019471)2.33913400
170nuclear envelope disassembly (GO:0051081)2.33628077
171membrane disassembly (GO:0030397)2.33628077
172very-low-density lipoprotein particle assembly (GO:0034379)2.33427147
173regulation of early endosome to late endosome transport (GO:2000641)2.33398501
174protein-lipid complex assembly (GO:0065005)2.33240226
175lactate metabolic process (GO:0006089)2.32111976
176axoneme assembly (GO:0035082)2.31814323
177histone lysine demethylation (GO:0070076)2.31257808
178spermatid development (GO:0007286)2.30902783
179mitotic G1/S transition checkpoint (GO:0044819)2.30739390
180positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.30720472
181negative regulation of cell fate specification (GO:0009996)2.30349708
182mitochondrion transport along microtubule (GO:0047497)2.29462148
183establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.29462148
184regulation of rhodopsin mediated signaling pathway (GO:0022400)11.7289624
185rhodopsin mediated signaling pathway (GO:0016056)11.6493061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.73221462
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.36974876
3E2F7_22180533_ChIP-Seq_HELA_Human3.03624630
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.86215605
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.85188869
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.84003517
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.51675946
8CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.26908235
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25839993
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21688386
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16405732
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14568606
13CLOCK_20551151_ChIP-Seq_293T_Human2.10766872
14RACK7_27058665_Chip-Seq_MCF-7_Human1.96756135
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.88318814
16* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.86992698
17* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79252278
18DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.74926738
19MYC_22102868_ChIP-Seq_BL_Human1.74888583
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.74643409
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.74261863
22ELK3_25401928_ChIP-Seq_HUVEC_Human1.73439239
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.71793255
24* KDM2B_26808549_Chip-Seq_K562_Human1.71700316
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71412027
26LXR_22292898_ChIP-Seq_THP-1_Human1.66634892
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63841442
28* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.62734075
29* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.61176773
30* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60271708
31VDR_21846776_ChIP-Seq_THP-1_Human1.58460587
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.57975352
33* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.57728237
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.55772004
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55699662
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.54705306
37* NANOG_21062744_ChIP-ChIP_HESCs_Human1.54215259
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52360322
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51948367
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51693577
41KDM2B_26808549_Chip-Seq_DND41_Human1.50977618
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.50368587
43TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.48974744
44TCF7_22412390_ChIP-Seq_EML_Mouse1.48487168
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48162528
46GATA1_26923725_Chip-Seq_HPCs_Mouse1.48103602
47MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47015298
48ATF3_27146783_Chip-Seq_COLON_Human1.46434093
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45929491
50PKCTHETA_26484144_Chip-Seq_BREAST_Human1.42765040
51* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42444171
52CREB1_26743006_Chip-Seq_LNCaP_Human1.40771605
53TBX3_20139965_ChIP-Seq_ESCs_Mouse1.38334226
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37818448
55POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37516546
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.37281083
57* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37231103
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.37201714
59* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36906863
60* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36210932
61TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36043961
62* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35426280
63P68_20966046_ChIP-Seq_HELA_Human1.35222041
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34805670
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34474961
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.34295253
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.34213034
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34030300
69ZNF263_19887448_ChIP-Seq_K562_Human1.33060575
70ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32821878
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.32692299
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32650435
73* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.32580766
74* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.32517049
75SMC4_20622854_ChIP-Seq_HELA_Human1.32205909
76* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32183858
77STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31851605
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.31229110
79SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31169615
80DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30961180
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.28188207
82* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27579480
83* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27391344
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25202486
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24676468
86* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24037152
87* KAP1_27257070_Chip-Seq_ESCs_Mouse1.21893020
88RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21658924
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21410483
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20866672
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20677834
92RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19687246
93SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.19382238
94POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18889500
95FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.18337227
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.18140493
97* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17888823
98MYC_19030024_ChIP-ChIP_MESCs_Mouse1.16704066
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16110993
100FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15211077
101NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14644282
102P300_27058665_Chip-Seq_ZR-75-30cells_Human1.14060663
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13656903
104* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.13431867
105* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12855852
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12723491
107FOXO3_23340844_ChIP-Seq_DLD1_Human1.11626176
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11420826
109SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10030604
110NCOR1_26117541_ChIP-Seq_K562_Human1.09830470
111SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09825995
112PPARA_22158963_ChIP-Seq_LIVER_Mouse1.09667021
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09156311
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08668597
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.07993607
116MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07870268
117* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06687454
118AR_21909140_ChIP-Seq_LNCAP_Human1.06377470
119* E2F1_21310950_ChIP-Seq_MCF-7_Human1.06180081
120RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06101277
121PHF8_20622854_ChIP-Seq_HELA_Human1.06020188
122* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05763020
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05212453
124* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.05120129
125OCT4_19829295_ChIP-Seq_ESCs_Human1.04709173
126RXR_22158963_ChIP-Seq_LIVER_Mouse1.04478604
127* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03662003
128CHD1_26751641_Chip-Seq_LNCaP_Human1.02321550
129* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00238789
130AR_19668381_ChIP-Seq_PC3_Human0.99453799
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98765876
132GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98044940
133TBL1_22424771_ChIP-Seq_293T_Human0.97435563
134* TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97258888
135* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96675926
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93158204
137EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93057495
138KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92283657
139KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92283657
140KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92283657
141GATA6_25053715_ChIP-Seq_YYC3_Human0.92093068
142EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91685249
143* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91339090
144* SMAD3_21741376_ChIP-Seq_HESCs_Human0.91281632
145KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90977213
146E2F1_20622854_ChIP-Seq_HELA_Human0.90884664
147FOXA2_19822575_ChIP-Seq_HepG2_Human0.90814891
148SPI1_26923725_Chip-Seq_HPCs_Mouse0.90729290

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation8.85597458
2MP0005551_abnormal_eye_electrophysiolog7.85710554
3MP0005253_abnormal_eye_physiology5.55957108
4MP0006072_abnormal_retinal_apoptosis5.40077920
5MP0003950_abnormal_plasma_membrane3.38932578
6MP0003878_abnormal_ear_physiology3.29226301
7MP0005377_hearing/vestibular/ear_phenot3.29226301
8MP0005195_abnormal_posterior_eye3.21503219
9MP0002653_abnormal_ependyma_morphology3.16582797
10MP0010234_abnormal_vibrissa_follicle3.08671329
11MP0001324_abnormal_eye_pigmentation3.01337205
12MP0005391_vision/eye_phenotype2.97320063
13MP0002090_abnormal_vision2.82052631
14MP0004233_abnormal_muscle_weight2.51911771
15MP0000566_synostosis2.46836929
16MP0005451_abnormal_body_composition2.32058507
17MP0003566_abnormal_cell_adhesion2.23811514
18MP0003941_abnormal_skin_development2.22378934
19MP0002796_impaired_skin_barrier2.03196975
20MP0002229_neurodegeneration1.91145116
21MP0005410_abnormal_fertilization1.86626630
22MP0001849_ear_inflammation1.77849667
23MP0004272_abnormal_basement_membrane1.71595975
24MP0005409_darkened_coat_color1.68444621
25MP0005076_abnormal_cell_differentiation1.67553459
26MP0003890_abnormal_embryonic-extraembry1.66750784
27MP0002132_abnormal_respiratory_system1.66536700
28MP0000537_abnormal_urethra_morphology1.61414435
29MP0003123_paternal_imprinting1.60187496
30MP0002089_abnormal_postnatal_growth/wei1.59401950
31MP0003453_abnormal_keratinocyte_physiol1.56268900
32MP0003111_abnormal_nucleus_morphology1.55956985
33MP0008057_abnormal_DNA_replication1.55549047
34MP0008877_abnormal_DNA_methylation1.53828646
35MP0003705_abnormal_hypodermis_morpholog1.51341804
36MP0000678_abnormal_parathyroid_gland1.50103435
37MP0001661_extended_life_span1.43680536
38MP0002752_abnormal_somatic_nervous1.40986763
39MP0002254_reproductive_system_inflammat1.40114934
40MP0002638_abnormal_pupillary_reflex1.37424008
41MP0001929_abnormal_gametogenesis1.31036486
42MP0000003_abnormal_adipose_tissue1.30888367
43MP0010352_gastrointestinal_tract_polyps1.30315178
44MP0003943_abnormal_hepatobiliary_system1.28669280
45MP0003698_abnormal_male_reproductive1.28140273
46MP0004858_abnormal_nervous_system1.27489160
47MP0000579_abnormal_nail_morphology1.26219591
48MP0010094_abnormal_chromosome_stability1.26166595
49MP0008260_abnormal_autophagy1.22668499
50MP0002396_abnormal_hematopoietic_system1.21675571
51MP0002009_preneoplasia1.20597479
52MP0001346_abnormal_lacrimal_gland1.19850570
53MP0005501_abnormal_skin_physiology1.18473423
54MP0010307_abnormal_tumor_latency1.15893546
55MP0004019_abnormal_vitamin_homeostasis1.15582911
56MP0003091_abnormal_cell_migration1.15059891
57MP0000762_abnormal_tongue_morphology1.14577870
58MP0010030_abnormal_orbit_morphology1.12145602
59MP0003077_abnormal_cell_cycle1.12135850
60MP0005423_abnormal_somatic_nervous1.09109907
61MP0001764_abnormal_homeostasis1.07889242
62MP0002332_abnormal_exercise_endurance1.07740456
63MP0005380_embryogenesis_phenotype1.07109189
64MP0001672_abnormal_embryogenesis/_devel1.07109189
65MP0001984_abnormal_olfaction1.05908562
66MP0008932_abnormal_embryonic_tissue1.05738852
67MP0001730_embryonic_growth_arrest1.05339709
68MP0005375_adipose_tissue_phenotype1.04503967
69MP0002210_abnormal_sex_determination1.02178700
70MP0000350_abnormal_cell_proliferation1.02173715
71MP0002127_abnormal_cardiovascular_syste1.00955035
72MP0005394_taste/olfaction_phenotype1.00685047
73MP0005499_abnormal_olfactory_system1.00685047
74MP0005248_abnormal_Harderian_gland1.00626087
75MP0003984_embryonic_growth_retardation1.00564671
76MP0002249_abnormal_larynx_morphology0.99253947
77MP0004264_abnormal_extraembryonic_tissu0.98476486
78MP0002088_abnormal_embryonic_growth/wei0.97857561
79MP0004808_abnormal_hematopoietic_stem0.95963614
80MP0003122_maternal_imprinting0.95311474
81MP0002085_abnormal_embryonic_tissue0.94560466
82MP0002084_abnormal_developmental_patter0.94368236
83MP0008058_abnormal_DNA_repair0.94065176
84MP0005621_abnormal_cell_physiology0.93129071
85MP0003942_abnormal_urinary_system0.93118886
86MP0006292_abnormal_olfactory_placode0.92763261
87MP0001216_abnormal_epidermal_layer0.92608027
88MP0001145_abnormal_male_reproductive0.92132644
89MP0001697_abnormal_embryo_size0.90825663
90MP0000569_abnormal_digit_pigmentation0.90478719
91MP0002060_abnormal_skin_morphology0.89708473
92MP0003646_muscle_fatigue0.87222567
93MP0002882_abnormal_neuron_morphology0.86665441
94MP0002161_abnormal_fertility/fecundity0.86563767
95MP0009840_abnormal_foam_cell0.86085487
96MP0005187_abnormal_penis_morphology0.85941063
97MP0004782_abnormal_surfactant_physiolog0.84286553
98MP0000653_abnormal_sex_gland0.83929608
99MP0000477_abnormal_intestine_morphology0.82776577
100MP0005623_abnormal_meninges_morphology0.82455720
101MP0000627_abnormal_mammary_gland0.82322622
102MP0008789_abnormal_olfactory_epithelium0.81488362
103MP0002111_abnormal_tail_morphology0.81308790
104MP0003567_abnormal_fetal_cardiomyocyte0.80247976
105MP0002086_abnormal_extraembryonic_tissu0.80170448
106MP0002098_abnormal_vibrissa_morphology0.78341435
107MP0000467_abnormal_esophagus_morphology0.78139840
108MP0001286_abnormal_eye_development0.78103677
109MP0008961_abnormal_basal_metabolism0.77618821
110MP0000490_abnormal_crypts_of0.77391610
111MP0008007_abnormal_cellular_replicative0.76773611
112MP0001502_abnormal_circadian_rhythm0.76744656
113MP0000313_abnormal_cell_death0.76642527
114MP0001293_anophthalmia0.76217382
115MP0000432_abnormal_head_morphology0.75610899
116MP0002909_abnormal_adrenal_gland0.75521813
117MP0002697_abnormal_eye_size0.74761261
118MP0001915_intracranial_hemorrhage0.73488462
119MP0009672_abnormal_birth_weight0.72544430
120MP0004185_abnormal_adipocyte_glucose0.72486723
121MP0002277_abnormal_respiratory_mucosa0.72044994
122MP0004197_abnormal_fetal_growth/weight/0.71224178
123MP0009703_decreased_birth_body0.70423642
124MP0004957_abnormal_blastocyst_morpholog0.70163316
125MP0003191_abnormal_cellular_cholesterol0.69957952
126MP0003937_abnormal_limbs/digits/tail_de0.69594262
127MP0004947_skin_inflammation0.69541083
128MP0005384_cellular_phenotype0.69104550
129MP0005023_abnormal_wound_healing0.67949152
130MP0003693_abnormal_embryo_hatching0.67949096
131MP0005197_abnormal_uvea_morphology0.67421072
132MP0002269_muscular_atrophy0.65551868
133MP0003935_abnormal_craniofacial_develop0.65548709
134MP0009278_abnormal_bone_marrow0.63205732
135MP0003115_abnormal_respiratory_system0.62493271
136MP0003119_abnormal_digestive_system0.62160499
137MP0002877_abnormal_melanocyte_morpholog0.61595054
138MP0002080_prenatal_lethality0.60578378
139MP0003699_abnormal_female_reproductive0.59842011
140MP0004885_abnormal_endolymph0.56390324
141MP0003045_fibrosis0.56240472
142MP0000428_abnormal_craniofacial_morphol0.55780988
143MP0005670_abnormal_white_adipose0.55671015
144MP0005257_abnormal_intraocular_pressure0.54973930
145MP0005365_abnormal_bile_salt0.53351596
146MP0002092_abnormal_eye_morphology0.53193267
147MP0003861_abnormal_nervous_system0.52302937
148MP0002925_abnormal_cardiovascular_devel0.51664821
149MP0010630_abnormal_cardiac_muscle0.50548487
150MP0010368_abnormal_lymphatic_system0.50310833
151MP0004084_abnormal_cardiac_muscle0.49387084
152MP0003283_abnormal_digestive_organ0.49364654
153MP0000733_abnormal_muscle_development0.47853389
154MP0002928_abnormal_bile_duct0.47704599
155MP0003252_abnormal_bile_duct0.46364076
156MP0008775_abnormal_heart_ventricle0.41869319
157MP0000534_abnormal_ureter_morphology0.41821249
158MP0005666_abnormal_adipose_tissue0.41304641

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.33967962
2Abnormality of macular pigmentation (HP:0008002)7.56005998
3Abnormal rod and cone electroretinograms (HP:0008323)7.52912875
4Dyschromatopsia (HP:0007641)7.51198535
5Scotoma (HP:0000575)7.46759156
6Absent rod-and cone-mediated responses on ERG (HP:0007688)7.25134859
7Pigmentary retinal degeneration (HP:0001146)6.94004129
8Chorioretinal atrophy (HP:0000533)6.68389470
9Attenuation of retinal blood vessels (HP:0007843)6.37569981
10Pendular nystagmus (HP:0012043)6.37003277
11Decreased central vision (HP:0007663)5.31477743
12Type II diabetes mellitus (HP:0005978)5.05543827
13Abolished electroretinogram (ERG) (HP:0000550)4.82006809
14Photophobia (HP:0000613)4.77521225
15Posterior subcapsular cataract (HP:0007787)4.75213165
16Cone-rod dystrophy (HP:0000548)4.58302428
17Choroideremia (HP:0001139)4.23466656
18Macular degeneration (HP:0000608)4.20858514
19Severe visual impairment (HP:0001141)3.93420599
20Constricted visual fields (HP:0001133)3.83820106
21Deep venous thrombosis (HP:0002625)3.55589812
22Vitreoretinal degeneration (HP:0000655)3.53805398
23Retinitis pigmentosa (HP:0000510)3.50622039
24Partial duplication of thumb phalanx (HP:0009944)3.46046033
25Subcapsular cataract (HP:0000523)3.38574859
26Abnormality of the salivary glands (HP:0010286)3.32987789
27Increased corneal curvature (HP:0100692)3.28535788
28Keratoconus (HP:0000563)3.28535788
29Aplasia involving bones of the extremities (HP:0009825)3.21646700
30Aplasia involving bones of the upper limbs (HP:0009823)3.21646700
31Aplasia of the phalanges of the hand (HP:0009802)3.21646700
32Partial duplication of the phalanx of hand (HP:0009999)2.96331448
33Flat acetabular roof (HP:0003180)2.78389378
34Septate vagina (HP:0001153)2.77634933
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.74694345
36Retinal atrophy (HP:0001105)2.67741825
37Progressive visual loss (HP:0000529)2.65262756
38Asymmetry of the thorax (HP:0001555)2.63599086
39Bronchomalacia (HP:0002780)2.61767399
40Abnormality of the lacrimal duct (HP:0011481)2.60346074
41Nasolacrimal duct obstruction (HP:0000579)2.52996864
42Obstructive sleep apnea (HP:0002870)2.52418352
43Duplication of thumb phalanx (HP:0009942)2.45760391
44Abnormality of the distal phalanx of the thumb (HP:0009617)2.40898234
45Congenital sensorineural hearing impairment (HP:0008527)2.36551653
46Ulnar bowing (HP:0003031)2.30462290
47Wide nasal bridge (HP:0000431)2.29303866
48Alacrima (HP:0000522)2.25042391
49Abnormality of the nasolacrimal system (HP:0000614)2.17417727
50Advanced eruption of teeth (HP:0006288)2.14927953
51Vaginal fistula (HP:0004320)2.14692853
52Shallow orbits (HP:0000586)2.12361763
53Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.12068430
54Vertebral arch anomaly (HP:0008438)2.11521210
55Long palpebral fissure (HP:0000637)2.11378466
56Right ventricular cardiomyopathy (HP:0011663)2.10977292
57Uterine leiomyosarcoma (HP:0002891)2.09353211
58Leiomyosarcoma (HP:0100243)2.09353211
59Malignant gastrointestinal tract tumors (HP:0006749)2.08461993
60Gastrointestinal carcinoma (HP:0002672)2.08461993
61Ankyloglossia (HP:0010296)2.07794264
62Intestinal fistula (HP:0100819)2.07108929
63Abnormality of carpal bone ossification (HP:0006257)2.03983045
64Abnormality of the lower motor neuron (HP:0002366)2.03968577
65Arnold-Chiari malformation (HP:0002308)2.02256969
66Congenital stationary night blindness (HP:0007642)13.2687879
67Bony spicule pigmentary retinopathy (HP:0007737)10.6497013
68Limited elbow extension (HP:0001377)1.99189596
69Heterotopia (HP:0002282)1.94333519
70Nephroblastoma (Wilms tumor) (HP:0002667)1.91684062
71Renal cell carcinoma (HP:0005584)1.91154727
72Abnormal ossification of hand bones (HP:0005921)1.90656214
73Absent radius (HP:0003974)1.90630032
74Germ cell neoplasia (HP:0100728)1.89984599
75Hepatoblastoma (HP:0002884)1.88297922
76Abnormality of the fingertips (HP:0001211)1.86620306
77Selective tooth agenesis (HP:0001592)1.85844806
78Glomerulonephritis (HP:0000099)1.85636579
79Abnormality of permanent molar morphology (HP:0011071)1.85499810
80Abnormality of the dental root (HP:0006486)1.85499810
81Taurodontia (HP:0000679)1.85499810
82Turricephaly (HP:0000262)1.84712329
83Progressive external ophthalmoplegia (HP:0000590)1.84490903
84Abnormal tarsal ossification (HP:0008369)1.83537443
85Abnormality of incisor morphology (HP:0011063)1.83200035
86Abnormality of the radial head (HP:0003995)1.83147698
87Aplasia involving forearm bones (HP:0009822)1.82881127
88Absent forearm bone (HP:0003953)1.82881127
89Deviation of the thumb (HP:0009603)1.82827451
90Hemorrhage of the eye (HP:0011885)1.82774652
91Transitional cell carcinoma of the bladder (HP:0006740)1.81113431
92Choanal stenosis (HP:0000452)1.80989579
93Small epiphyses (HP:0010585)1.79044935
94Deep palmar crease (HP:0006191)1.78794225
95Trigonocephaly (HP:0000243)1.76408631
96Embryonal renal neoplasm (HP:0011794)1.76198849
97Cubitus valgus (HP:0002967)1.74851973
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.73797098
99Bifid scrotum (HP:0000048)1.73472382
100Pterygium (HP:0001059)1.73025390
101Disproportionate tall stature (HP:0001519)1.72383992
102Subacute progressive viral hepatitis (HP:0006572)1.71786538
103Male infertility (HP:0003251)1.68587518
104Dislocated radial head (HP:0003083)1.68413371
105Decreased lacrimation (HP:0000633)1.68084472
106Skull defect (HP:0001362)1.67870813
107Congenital primary aphakia (HP:0007707)1.65912750
108Broad face (HP:0000283)1.65631274
109Abnormality of molar (HP:0011077)1.64527695
110Abnormality of molar morphology (HP:0011070)1.64527695
111Bladder carcinoma (HP:0002862)1.64084105
112Bladder neoplasm (HP:0009725)1.64084105
113Embryonal neoplasm (HP:0002898)1.62844630
114Segmental peripheral demyelination/remyelination (HP:0003481)1.62382383
115Abnormality of the astrocytes (HP:0100707)1.61833938
116Astrocytoma (HP:0009592)1.61833938
117Abnormality of the humeroradial joint (HP:0100744)1.61562779
118Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61160976
119Absent eyebrow (HP:0002223)1.61123212
120Gait imbalance (HP:0002141)1.60904464
121Mixed hearing impairment (HP:0000410)1.60079948
122Progressive hearing impairment (HP:0001730)1.59115229
123Abnormality of the phalanges of the hallux (HP:0010057)1.58884276
124Thickened helices (HP:0000391)1.58441895
125Lip pit (HP:0100267)1.57597012
126Abnormality of the nasal septum (HP:0000419)1.57111650
127Rectal fistula (HP:0100590)1.57070376
128Rectovaginal fistula (HP:0000143)1.57070376
129Horizontal nystagmus (HP:0000666)1.56633067
130Poor coordination (HP:0002370)1.55838740
131Abnormality of the dental pulp (HP:0006479)1.55345278
132Absent eyelashes (HP:0000561)1.55023735
133Broad palm (HP:0001169)1.53694889
134Broad thumb (HP:0011304)1.53677620
135Proximal placement of thumb (HP:0009623)1.53354100
136Hypercholesterolemia (HP:0003124)1.51743677
137Cystic liver disease (HP:0006706)1.50734651
138Genetic anticipation (HP:0003743)1.50224810
139Polar cataract (HP:0010696)1.48900335
140Renovascular hypertension (HP:0100817)1.46082145
141Ependymoma (HP:0002888)1.44574353
142Aplasia/Hypoplasia of the fovea (HP:0008060)1.43848630
143Hypoplasia of the fovea (HP:0007750)1.43848630
144Aplasia/Hypoplasia of the macula (HP:0008059)1.43086897
145Truncal obesity (HP:0001956)1.41414112
146Neoplasm of the oral cavity (HP:0100649)1.41345029
147Impulsivity (HP:0100710)1.38351041
148Volvulus (HP:0002580)1.37669993
149Medial flaring of the eyebrow (HP:0010747)1.35996599
150Dysmetric saccades (HP:0000641)1.35668218
151Abnormality of the fovea (HP:0000493)1.34799676
152Papillary thyroid carcinoma (HP:0002895)1.34789563
153Aplasia/Hypoplasia affecting the retina (HP:0008061)1.34663522
154Macroorchidism (HP:0000053)1.33717649
155Pancreatic fibrosis (HP:0100732)1.32099694
156Nephrogenic diabetes insipidus (HP:0009806)1.31779957
157Abnormality of abdominal situs (HP:0011620)1.30953227
158Abdominal situs inversus (HP:0003363)1.30953227
159Increased nuchal translucency (HP:0010880)1.29897247
160Glioma (HP:0009733)1.28536785
161Optic atrophy (HP:0000648)1.25962584
162Dysdiadochokinesis (HP:0002075)1.25071292
163Molar tooth sign on MRI (HP:0002419)1.24398116
164Abnormality of midbrain morphology (HP:0002418)1.24398116
165Elfin facies (HP:0004428)1.23503738
166Astigmatism (HP:0000483)1.21091905
167Prominent nose (HP:0000448)1.20109497
168Dynein arm defect of respiratory motile cilia (HP:0012255)1.19868482
169Absent/shortened dynein arms (HP:0200106)1.19868482
170Long eyelashes (HP:0000527)1.19191950
171Hyperacusis (HP:0010780)1.19170719
172Aplasia/Hypoplasia of the tongue (HP:0010295)1.15320857
173Shawl scrotum (HP:0000049)1.14219195
174Urethral obstruction (HP:0000796)1.13838814
175Anal stenosis (HP:0002025)1.13133993
176Facial hemangioma (HP:0000329)1.11851097
177Hand muscle atrophy (HP:0009130)1.08594604
178Severe Myopia (HP:0011003)1.08009296
179Short humerus (HP:0005792)1.08002331
180Pancreatic cysts (HP:0001737)1.07894848
181Oligodactyly (hands) (HP:0001180)1.07690952
182Vaginal atresia (HP:0000148)1.06126408
183Nephronophthisis (HP:0000090)1.05972047
184Renal duplication (HP:0000075)1.05211848
185Chronic bronchitis (HP:0004469)1.03915788
186Retinal detachment (HP:0000541)1.02119810
187Infertility (HP:0000789)1.02098742
188Genital tract atresia (HP:0001827)1.01795603
189Neoplasm of striated muscle (HP:0009728)1.01078714
190Decreased testicular size (HP:0008734)1.00000718
191Ectopic kidney (HP:0000086)0.99813011
192True hermaphroditism (HP:0010459)0.96448294
193Chorioretinal coloboma (HP:0000567)0.96178043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK15.33189759
2CDK124.94735045
3SMG13.97820576
4ICK3.27495571
5LATS13.15403740
6PRKD32.86002915
7NEK22.82840924
8FGFR42.80998684
9PRPF4B2.30949182
10TTK2.20101798
11STK382.17130948
12MAP3K101.92657015
13STK38L1.87361527
14PINK11.84606644
15BRD41.72371377
16CAMK1D1.69853391
17LATS21.67955272
18AKT31.67087760
19NEK11.61036593
20FGFR21.56552629
21CDC71.55656905
22MAP3K61.55491030
23CAMK1G1.53724462
24CHEK21.53364521
25RIPK11.53205173
26STK31.52855543
27PDK31.48807744
28PDK41.48807744
29PBK1.45687107
30FGFR31.39078770
31IRAK31.38021266
32MST1R1.37493332
33MTOR1.37258665
34PAK61.35425222
35TYRO31.33409116
36MAP3K131.27701027
37TAOK31.23302610
38PAK41.19612191
39DYRK1B1.17263113
40PRKAA11.15669567
41MAP3K31.10718928
42CHEK11.06164092
43PTK21.05206897
44PLK11.03566790
45STK241.00298109
46MET1.00288227
47CDK90.97791481
48FGFR10.97091350
49EEF2K0.97027042
50MAP3K80.96364005
51HIPK20.93554411
52LMTK20.92713646
53CDK70.90135253
54ATR0.89525974
55MAP3K20.89266685
56PDK20.88171198
57TAOK10.87956970
58EPHB10.87745479
59TRIB30.87620751
60ATM0.86282824
61CDK40.84087290
62CSNK1D0.83830846
63PDGFRA0.83145108
64CDK60.82883115
65SGK30.81956486
66PLK30.81459300
67MAP3K40.80275998
68MELK0.80187261
69BRAF0.79183500
70NTRK10.78539473
71RPS6KA40.78213133
72MAP3K10.75332663
73PRKD20.75209129
74CDK20.74846955
75DDR20.74309069
76MAP2K30.73742307
77SIK10.73300785
78PDPK10.72866230
79STK40.72139134
80BUB10.71745280
81MARK20.71243244
82CDK10.68900264
83YES10.67450666
84SGK20.66607445
85RET0.66159306
86PRKAA20.64762773
87DYRK30.64349771
88CDC42BPA0.64233777
89WNK10.64154503
90GSK3B0.62140104
91MAPK140.61002595
92TSSK60.59471651
93ERBB20.59057792
94PKN20.58958075
95MAPK100.58383041
96SIK20.56394055
97IRAK20.56114601
98TTN0.55867072
99MAPK110.54963056
100CDK30.54078982
101ALK0.53691053
102DMPK0.53671955
103FGR0.53429208
104MAP3K90.53425585
105TESK10.52445005
106ERN10.51995930
107AKT20.50872403
108INSRR0.50170992
109BMX0.50050840
110MAPK70.49609419
111EIF2AK10.47551114
112DYRK1A0.47218218
113MAPK10.46216106
114KSR20.45859418
115PRKDC0.45485953
116PDK10.43953701
117PRKCZ0.43859553
118RPS6KA30.43858777
119ARAF0.43525627
120FRK0.43068726
121KSR10.41986298
122NLK0.40574073
123TAOK20.40237177
124EPHA20.39634285
125AURKB0.39541445
126RPS6KC10.39423743
127RPS6KL10.39423743
128BRSK20.39009091
129ERBB40.38340317
130RAF10.38305000
131PDGFRB0.38295617
132PTK60.37813718
133MAP3K50.37780358
134CSNK1E0.37745632
135BRSK10.36560876
136STK100.36555832
137PASK0.36325255
138SGK4940.35695027
139MAPK80.35516043
140AKT10.35398392
141RPS6KA10.35123202
142CHUK0.35115509
143PIM10.34745237
144MAP3K140.34432739
145RPS6KB20.33914173
146SGK2230.33748339

Predicted pathways (KEGG)

RankGene SetZ-score
1Thyroid cancer_Homo sapiens_hsa052162.44183332
2Phototransduction_Homo sapiens_hsa0474413.0037270
3Prostate cancer_Homo sapiens_hsa052151.65273952
4Acute myeloid leukemia_Homo sapiens_hsa052211.59908475
5Circadian rhythm_Homo sapiens_hsa047101.52416884
6Bladder cancer_Homo sapiens_hsa052191.43616061
7Lysine degradation_Homo sapiens_hsa003101.35053243
8mTOR signaling pathway_Homo sapiens_hsa041501.34338205
9ErbB signaling pathway_Homo sapiens_hsa040121.20193363
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19725965
11Proteoglycans in cancer_Homo sapiens_hsa052051.16539273
12mRNA surveillance pathway_Homo sapiens_hsa030151.14175964
13Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13995447
14DNA replication_Homo sapiens_hsa030301.08782032
15Olfactory transduction_Homo sapiens_hsa047401.06781270
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.04084875
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.01760309
18Vitamin B6 metabolism_Homo sapiens_hsa007501.01740292
19Nitrogen metabolism_Homo sapiens_hsa009101.01213860
20Synaptic vesicle cycle_Homo sapiens_hsa047211.00523321
21Neurotrophin signaling pathway_Homo sapiens_hsa047220.99408701
22Other glycan degradation_Homo sapiens_hsa005110.96842497
23Cell cycle_Homo sapiens_hsa041100.96540003
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95198963
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93764169
26Fructose and mannose metabolism_Homo sapiens_hsa000510.93636161
27AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92801085
28Spliceosome_Homo sapiens_hsa030400.91718874
29Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89455749
30Fatty acid biosynthesis_Homo sapiens_hsa000610.88813513
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88383286
32RNA transport_Homo sapiens_hsa030130.87924316
33Prolactin signaling pathway_Homo sapiens_hsa049170.86972318
34Central carbon metabolism in cancer_Homo sapiens_hsa052300.86414038
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.86321711
36Focal adhesion_Homo sapiens_hsa045100.85098008
37Viral carcinogenesis_Homo sapiens_hsa052030.84657207
38Oocyte meiosis_Homo sapiens_hsa041140.83955684
39Melanoma_Homo sapiens_hsa052180.83841067
40Cyanoamino acid metabolism_Homo sapiens_hsa004600.82062064
41Hepatitis C_Homo sapiens_hsa051600.81004335
42Biosynthesis of amino acids_Homo sapiens_hsa012300.80837131
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79883950
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79798780
45Hepatitis B_Homo sapiens_hsa051610.78354213
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76858395
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76615766
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76523810
49Glucagon signaling pathway_Homo sapiens_hsa049220.76377762
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74735381
51Dorso-ventral axis formation_Homo sapiens_hsa043200.74333989
52AMPK signaling pathway_Homo sapiens_hsa041520.73688846
53ABC transporters_Homo sapiens_hsa020100.72706139
54Inositol phosphate metabolism_Homo sapiens_hsa005620.72644643
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72317907
56GABAergic synapse_Homo sapiens_hsa047270.72301886
57Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72082703
58Steroid biosynthesis_Homo sapiens_hsa001000.71889958
59Pathways in cancer_Homo sapiens_hsa052000.71816025
60Adherens junction_Homo sapiens_hsa045200.71163448
61Hippo signaling pathway_Homo sapiens_hsa043900.70993126
62Vitamin digestion and absorption_Homo sapiens_hsa049770.69085000
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68576619
64Insulin secretion_Homo sapiens_hsa049110.68561080
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68281749
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67424922
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.67165776
68Apoptosis_Homo sapiens_hsa042100.67010501
69Estrogen signaling pathway_Homo sapiens_hsa049150.65839207
70Retinol metabolism_Homo sapiens_hsa008300.65719260
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.65697465
72Carbon metabolism_Homo sapiens_hsa012000.65567140
73Glycerolipid metabolism_Homo sapiens_hsa005610.65411626
74Long-term potentiation_Homo sapiens_hsa047200.65400976
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65090018
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64574326
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64207193
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63957798
79Fanconi anemia pathway_Homo sapiens_hsa034600.63328892
80Prion diseases_Homo sapiens_hsa050200.63026155
81Notch signaling pathway_Homo sapiens_hsa043300.62760786
82Amoebiasis_Homo sapiens_hsa051460.62568991
83B cell receptor signaling pathway_Homo sapiens_hsa046620.61625286
84Type II diabetes mellitus_Homo sapiens_hsa049300.60654095
85RNA degradation_Homo sapiens_hsa030180.60209288
86Endometrial cancer_Homo sapiens_hsa052130.59857332
87Selenocompound metabolism_Homo sapiens_hsa004500.59638244
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.59449566
89ECM-receptor interaction_Homo sapiens_hsa045120.58518098
90Arginine biosynthesis_Homo sapiens_hsa002200.57564126
91Rap1 signaling pathway_Homo sapiens_hsa040150.56719623
92One carbon pool by folate_Homo sapiens_hsa006700.56698510
93MicroRNAs in cancer_Homo sapiens_hsa052060.55369058
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54931510
95Thyroid hormone synthesis_Homo sapiens_hsa049180.54060656
96Melanogenesis_Homo sapiens_hsa049160.53633030
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52204185
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50570067
99Cholinergic synapse_Homo sapiens_hsa047250.49251797
100Basal transcription factors_Homo sapiens_hsa030220.48713293
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48586457
102Hedgehog signaling pathway_Homo sapiens_hsa043400.47936562
103Insulin resistance_Homo sapiens_hsa049310.47286761
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46044761
105HIF-1 signaling pathway_Homo sapiens_hsa040660.45724078
106Tight junction_Homo sapiens_hsa045300.43379119
107Pentose phosphate pathway_Homo sapiens_hsa000300.43309995
108Base excision repair_Homo sapiens_hsa034100.42658168
109p53 signaling pathway_Homo sapiens_hsa041150.41562404
110Dilated cardiomyopathy_Homo sapiens_hsa054140.41114456
111Basal cell carcinoma_Homo sapiens_hsa052170.41112226
112Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40951043
113Linoleic acid metabolism_Homo sapiens_hsa005910.40590369
114Chronic myeloid leukemia_Homo sapiens_hsa052200.40015702
115Colorectal cancer_Homo sapiens_hsa052100.39999379
116Bile secretion_Homo sapiens_hsa049760.39891425
117Mineral absorption_Homo sapiens_hsa049780.39505952
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.38709152
119Dopaminergic synapse_Homo sapiens_hsa047280.38560904
120VEGF signaling pathway_Homo sapiens_hsa043700.38528083
121Circadian entrainment_Homo sapiens_hsa047130.38489229
122Oxytocin signaling pathway_Homo sapiens_hsa049210.38168520
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37736977
124Purine metabolism_Homo sapiens_hsa002300.37522228
125TGF-beta signaling pathway_Homo sapiens_hsa043500.36948693
126Wnt signaling pathway_Homo sapiens_hsa043100.36137230
127Insulin signaling pathway_Homo sapiens_hsa049100.36033780
128Choline metabolism in cancer_Homo sapiens_hsa052310.35385375
129Small cell lung cancer_Homo sapiens_hsa052220.34939571
130Glutamatergic synapse_Homo sapiens_hsa047240.33583044
131Morphine addiction_Homo sapiens_hsa050320.33095782
132FoxO signaling pathway_Homo sapiens_hsa040680.32199072
133Renal cell carcinoma_Homo sapiens_hsa052110.32147146
134Non-small cell lung cancer_Homo sapiens_hsa052230.31736512
135Glioma_Homo sapiens_hsa052140.31325008
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.30276830
137GnRH signaling pathway_Homo sapiens_hsa049120.29913674
138cAMP signaling pathway_Homo sapiens_hsa040240.29714485
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29283786
140Galactose metabolism_Homo sapiens_hsa000520.28318853
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.27880901
142Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27804635
143Pancreatic cancer_Homo sapiens_hsa052120.27753795
144Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.26464720

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