STK36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.18672377
2cilium or flagellum-dependent cell motility (GO:0001539)9.08006679
3piRNA metabolic process (GO:0034587)8.67541184
4sperm motility (GO:0030317)8.62174842
5fusion of sperm to egg plasma membrane (GO:0007342)8.35094152
6multicellular organism reproduction (GO:0032504)8.21632722
7* epithelial cilium movement (GO:0003351)7.81188858
8sperm-egg recognition (GO:0035036)7.60247445
9acrosome reaction (GO:0007340)7.56415121
10* cilium movement (GO:0003341)7.44751318
11binding of sperm to zona pellucida (GO:0007339)7.11357608
12motile cilium assembly (GO:0044458)6.93863471
13male meiosis (GO:0007140)6.68110128
14cell-cell recognition (GO:0009988)6.65889640
15reproduction (GO:0000003)6.62130699
16spermatid development (GO:0007286)6.61699278
17acrosome assembly (GO:0001675)6.57324081
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.53540397
19regulation of cilium movement (GO:0003352)6.51850735
20plasma membrane fusion (GO:0045026)6.33844738
21synaptonemal complex organization (GO:0070193)6.28194438
22cell wall macromolecule catabolic process (GO:0016998)6.14029678
23cell wall macromolecule metabolic process (GO:0044036)6.14029678
24synaptonemal complex assembly (GO:0007130)6.01982984
25single fertilization (GO:0007338)5.77343288
26DNA methylation involved in gamete generation (GO:0043046)5.76724753
27fertilization (GO:0009566)5.29576172
28microtubule depolymerization (GO:0007019)5.21974664
29spermatogenesis (GO:0007283)4.95487094
30male gamete generation (GO:0048232)4.93460635
31microtubule severing (GO:0051013)4.89636308
32male meiosis I (GO:0007141)4.88707170
33gamete generation (GO:0007276)4.74391607
34sperm capacitation (GO:0048240)4.65771694
35negative regulation of inclusion body assembly (GO:0090084)4.43631747
36germ cell development (GO:0007281)4.41858781
37chromosome organization involved in meiosis (GO:0070192)4.36364335
38meiotic cell cycle (GO:0051321)4.36017137
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.25334294
40ventricular system development (GO:0021591)4.25021836
41regulation of microtubule-based movement (GO:0060632)4.10852450
42protein polyglutamylation (GO:0018095)4.09694851
43nuclear pore complex assembly (GO:0051292)4.07757959
44meiotic nuclear division (GO:0007126)4.04400990
45regulation of meiosis I (GO:0060631)4.02373638
46axoneme assembly (GO:0035082)3.95844242
47meiosis I (GO:0007127)3.92284441
48regulation of inclusion body assembly (GO:0090083)3.87580032
49intraciliary transport (GO:0042073)3.84655782
50left/right pattern formation (GO:0060972)3.77213855
51multicellular organismal reproductive process (GO:0048609)3.69842775
52cell recognition (GO:0008037)3.61378811
53calcium ion-dependent exocytosis (GO:0017156)3.60448233
54gene silencing by RNA (GO:0031047)3.50972082
55seminiferous tubule development (GO:0072520)3.48401776
56organic cation transport (GO:0015695)3.46538501
57* positive regulation of smoothened signaling pathway (GO:0045880)3.45607590
58* cilium organization (GO:0044782)3.44616271
59RNA localization (GO:0006403)3.44385445
60lung epithelium development (GO:0060428)3.44186319
61postsynaptic membrane organization (GO:0001941)3.42503071
62nonmotile primary cilium assembly (GO:0035058)3.39238842
63neuron projection extension involved in neuron projection guidance (GO:1902284)3.36517641
64axon extension involved in axon guidance (GO:0048846)3.36517641
65planar cell polarity pathway involved in neural tube closure (GO:0090179)3.36123350
66vitamin transmembrane transport (GO:0035461)3.34969365
67mitotic sister chromatid cohesion (GO:0007064)3.34300095
68* cilium assembly (GO:0042384)3.33366963
69interkinetic nuclear migration (GO:0022027)3.33188994
70DNA alkylation (GO:0006305)3.29435996
71DNA methylation (GO:0006306)3.29435996
72cytoplasmic microtubule organization (GO:0031122)3.27670020
73presynaptic membrane assembly (GO:0097105)3.25712697
74regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19566896
75nuclear pore organization (GO:0006999)3.17276633
76synapsis (GO:0007129)3.16029332
77cilium morphogenesis (GO:0060271)3.15105159
78monoubiquitinated protein deubiquitination (GO:0035520)3.15014971
79metanephric mesenchyme development (GO:0072075)3.12812824
80establishment of planar polarity (GO:0001736)3.12665216
81establishment of tissue polarity (GO:0007164)3.12665216
82chromosome condensation (GO:0030261)3.11794797
83spermatid nucleus differentiation (GO:0007289)3.09173833
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.08757932
85negative regulation of organelle assembly (GO:1902116)3.08592972
86regulation of centriole replication (GO:0046599)3.08116783
87meiotic cell cycle process (GO:1903046)3.02556534
88regulation of acrosome reaction (GO:0060046)3.01488594
89genitalia morphogenesis (GO:0035112)3.00250458
90* microtubule-based movement (GO:0007018)2.97340311
91protein complex localization (GO:0031503)2.96373989
92appendage development (GO:0048736)2.95024382
93limb development (GO:0060173)2.95024382
94multicellular organismal development (GO:0007275)2.94996354
95DNA packaging (GO:0006323)2.94205899
96centriole assembly (GO:0098534)2.93516434
97camera-type eye morphogenesis (GO:0048593)2.92558014
98apical protein localization (GO:0045176)2.88826586
99establishment or maintenance of monopolar cell polarity (GO:0061339)2.87903870
100establishment of monopolar cell polarity (GO:0061162)2.87903870
101presynaptic membrane organization (GO:0097090)2.87802385
102pore complex assembly (GO:0046931)2.87675889
103* cellular component assembly involved in morphogenesis (GO:0010927)2.87351224
104nucleus organization (GO:0006997)2.87010969
105eye photoreceptor cell differentiation (GO:0001754)2.85511162
106photoreceptor cell differentiation (GO:0046530)2.85511162
107Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.85276331
108establishment of apical/basal cell polarity (GO:0035089)2.80597965
109protein localization to cilium (GO:0061512)2.80177557
110positive regulation of male gonad development (GO:2000020)2.79857381
111convergent extension (GO:0060026)2.79795411
112left/right axis specification (GO:0070986)2.78169419
113regulation of short-term neuronal synaptic plasticity (GO:0048172)2.77576777
114microtubule polymerization or depolymerization (GO:0031109)2.77245795
115cell-cell junction maintenance (GO:0045217)2.76365747
116embryonic retina morphogenesis in camera-type eye (GO:0060059)2.74908974
117regulation of meiosis (GO:0040020)2.73437992
118regulation of establishment of planar polarity (GO:0090175)2.70829861
119kidney mesenchyme development (GO:0072074)2.70589726
120embryonic camera-type eye development (GO:0031076)2.69618630
121glycerol ether metabolic process (GO:0006662)2.65970064
122protein localization to chromosome, centromeric region (GO:0071459)2.65145580
123regulation of axon extension involved in axon guidance (GO:0048841)2.64814906
124stress granule assembly (GO:0034063)2.64604590
125positive regulation of mesonephros development (GO:0061213)2.61708824
126centriole replication (GO:0007099)2.61671430
127regulation of axon guidance (GO:1902667)2.60709252
128semaphorin-plexin signaling pathway (GO:0071526)2.59994413
129microtubule bundle formation (GO:0001578)2.59790151
130synaptic vesicle docking involved in exocytosis (GO:0016081)2.58674089
131neurotransmitter-gated ion channel clustering (GO:0072578)2.53250792
132oocyte development (GO:0048599)2.52369566
133gene silencing (GO:0016458)2.51074391
134regulation of spindle checkpoint (GO:0090231)2.50017321
135digestive tract morphogenesis (GO:0048546)2.49592586
136lateral sprouting from an epithelium (GO:0060601)2.49279553
137female gamete generation (GO:0007292)2.48991343
138vocalization behavior (GO:0071625)2.48256365
139* regulation of smoothened signaling pathway (GO:0008589)2.48237452
140histone H2A acetylation (GO:0043968)2.47537846
141DNA methylation or demethylation (GO:0044728)2.46294164
142cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.44773679
143positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.44528845
144auditory behavior (GO:0031223)2.41448207
145paraxial mesoderm development (GO:0048339)2.38916005
146regulation of non-canonical Wnt signaling pathway (GO:2000050)2.38589537
147dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.37450613
148asymmetric protein localization (GO:0008105)2.37305360
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.35869890
150axonal fasciculation (GO:0007413)2.35526293
151regulation of mesonephros development (GO:0061217)2.35129909
152glomerular basement membrane development (GO:0032836)2.34904835
153negative regulation of axon guidance (GO:1902668)2.34787519
154neuron recognition (GO:0008038)2.34115181
155cellular response to cholesterol (GO:0071397)2.28916754
156mechanosensory behavior (GO:0007638)2.28908203
157protein localization to synapse (GO:0035418)2.28713321
158axon extension (GO:0048675)2.28042270
159olfactory bulb development (GO:0021772)2.26525137
160ganglion development (GO:0061548)2.25594957
161mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.25285989
162regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.25165398
163smoothened signaling pathway (GO:0007224)2.24498394
164regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.24107926
165chondroitin sulfate catabolic process (GO:0030207)2.23353606
166negative regulation of chondrocyte differentiation (GO:0032331)2.23019597
167ear development (GO:0043583)2.22139973
168gastrulation with mouth forming second (GO:0001702)2.20731523
169head development (GO:0060322)2.20532163
170cochlea morphogenesis (GO:0090103)2.20307015
171regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.17449164
172cell junction maintenance (GO:0034331)2.17333289
173developmental cell growth (GO:0048588)2.16890835
174hair follicle development (GO:0001942)2.15907348
175retinal ganglion cell axon guidance (GO:0031290)2.15281820
176neural tube closure (GO:0001843)2.14161732
177renal system development (GO:0072001)2.14104595
178non-canonical Wnt signaling pathway (GO:0035567)2.13896250

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34527813
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.25079185
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.85374406
4GATA1_26923725_Chip-Seq_HPCs_Mouse2.91764671
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.80368098
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.78840936
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44435279
8DROSHA_22980978_ChIP-Seq_HELA_Human2.01614591
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99312765
10CBX2_27304074_Chip-Seq_ESCs_Mouse1.84446833
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82958084
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79816964
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79146994
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73766559
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69391937
16MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.69160609
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.67761313
18RNF2_27304074_Chip-Seq_NSC_Mouse1.67357047
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65471030
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65203973
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63240580
22ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62030917
23ZNF274_21170338_ChIP-Seq_K562_Hela1.61001537
24TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60073117
25POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60073117
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.57426276
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54735954
28ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53794120
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53661975
30CLOCK_20551151_ChIP-Seq_293T_Human1.52912664
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.52765331
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.52669418
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52571746
34KAP1_22055183_ChIP-Seq_ESCs_Mouse1.48834738
35REST_21632747_ChIP-Seq_MESCs_Mouse1.48269699
36RUNX1_26923725_Chip-Seq_HPCs_Mouse1.46974811
37EED_16625203_ChIP-ChIP_MESCs_Mouse1.46283896
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.46243365
39EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45958111
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45958111
41KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41681608
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39206945
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.36125808
44TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.35957064
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.35000344
46SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34912449
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34541688
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.33067725
49AHR_22903824_ChIP-Seq_MCF-7_Human1.33051307
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.31060662
51ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30540113
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30329460
53STAT1_17558387_ChIP-Seq_HELA_Human1.26522824
54ESR1_20079471_ChIP-ChIP_T-47D_Human1.26231013
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.26164063
56NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.26128187
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26081017
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24550447
59TAL1_26923725_Chip-Seq_HPCs_Mouse1.24124094
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.23773893
61SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.23579862
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22569626
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.22373057
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.21030499
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.19882704
66CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.18927807
67POU5F1_16518401_ChIP-PET_MESCs_Mouse1.18328967
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.18271962
69AR_21572438_ChIP-Seq_LNCaP_Human1.17609762
70STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16246074
71KDM2B_26808549_Chip-Seq_REH_Human1.15408762
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14997640
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14746095
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14577987
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.14537925
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.13742047
77* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12709942
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12698947
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12688667
80RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12314217
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.10956168
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10550572
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10353219
84CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09465813
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08610922
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08400538
87VDR_22108803_ChIP-Seq_LS180_Human1.08331506
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08203624
89SOX3_22085726_ChIP-Seq_NPCs_Mouse1.08077339
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.07996769
91WT1_19549856_ChIP-ChIP_CCG9911_Human1.06489809
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06424775
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05904815
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05778560
95RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05696626
96SMAD3_21741376_ChIP-Seq_ESCs_Human1.05404875
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05189214
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04612605
99FOXM1_23109430_ChIP-Seq_U2OS_Human1.04404338
100RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04322454
101GF1_26923725_Chip-Seq_HPCs_Mouse1.03901422
102TBL1_22424771_ChIP-Seq_293T_Human1.03866557
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.03526116
104HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03420080
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02229527
106* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.02022630
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01869120
108SMAD4_21799915_ChIP-Seq_A2780_Human1.01712668
109* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00517063
110FLI1_21867929_ChIP-Seq_TH2_Mouse1.00481859
111GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.00150923
112GBX2_23144817_ChIP-Seq_PC3_Human0.99711937
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99544288
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99335170
115TCF4_23295773_ChIP-Seq_U87_Human0.98701675
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98622886
117CBP_20019798_ChIP-Seq_JUKART_Human0.98622886
118GF1B_26923725_Chip-Seq_HPCs_Mouse0.98388312
119EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97990153
120RUNX1_27514584_Chip-Seq_MCF-7_Human0.97721538
121* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96837325
122* NANOG_18555785_Chip-Seq_ESCs_Mouse0.96805401
123KDM2B_26808549_Chip-Seq_K562_Human0.96571190
124SMC4_20622854_ChIP-Seq_HELA_Human0.96391330
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.96202599
126CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95842542
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95344240
128AR_19668381_ChIP-Seq_PC3_Human0.95075257
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94912155
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.94442304
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.94133282
132FUS_26573619_Chip-Seq_HEK293_Human0.93732007
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93692113
134SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93284825
135TAF15_26573619_Chip-Seq_HEK293_Human0.93016654
136* NFE2_27457419_Chip-Seq_LIVER_Mouse0.92802803
137TP53_20018659_ChIP-ChIP_R1E_Mouse0.92403772
138TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92204856
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.92174706
140CREB1_26743006_Chip-Seq_LNCaP_Human0.92101676
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91631347
142STAT3_23295773_ChIP-Seq_U87_Human0.91537298
143SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91171619
144NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.90413559
145TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90367831
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.90315529
147EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90013742
148E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89714990
149SOX2_22085726_ChIP-Seq_NPCs_Mouse0.89414029
150FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89036159
151SOX9_26525672_Chip-Seq_HEART_Mouse0.88848445
152NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88530567
153RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88490585
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.88264601
155NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87032999
156* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86750675
157SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86260966
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84798986
159MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.84413381
160RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.84313285
161NFYB_21822215_ChIP-Seq_K562_Human0.83921735
162RING1B_27294783_Chip-Seq_ESCs_Mouse0.83339163
163TP63_19390658_ChIP-ChIP_HaCaT_Human0.83196793
164ETV1_20927104_ChIP-Seq_GIST48_Human0.82897758
165LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.82357329
166EZH2_27304074_Chip-Seq_ESCs_Mouse0.81985076
167NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80548039
168ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79217559
169REST_18959480_ChIP-ChIP_MESCs_Mouse0.77886500

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.71372438
2MP0002653_abnormal_ependyma_morphology5.21394199
3MP0008877_abnormal_DNA_methylation4.04979848
4* MP0003698_abnormal_male_reproductive3.88806855
5MP0001929_abnormal_gametogenesis3.85221378
6MP0002210_abnormal_sex_determination2.81873938
7MP0003136_yellow_coat_color2.73727740
8MP0003646_muscle_fatigue2.69842944
9MP0003787_abnormal_imprinting2.69147120
10MP0000569_abnormal_digit_pigmentation2.62627706
11* MP0002161_abnormal_fertility/fecundity2.48192736
12MP0009384_cardiac_valve_regurgitation2.43323677
13MP0003122_maternal_imprinting2.35991925
14MP0000653_abnormal_sex_gland2.25557129
15MP0001145_abnormal_male_reproductive2.25004163
16MP0002102_abnormal_ear_morphology2.08197327
17MP0005248_abnormal_Harderian_gland1.77609817
18MP0002282_abnormal_trachea_morphology1.77210639
19MP0001293_anophthalmia1.63863366
20MP0002938_white_spotting1.63374856
21MP0003121_genomic_imprinting1.61846549
22MP0008875_abnormal_xenobiotic_pharmacok1.60513850
23MP0005503_abnormal_tendon_morphology1.57228301
24MP0003880_abnormal_central_pattern1.56959632
25MP0002234_abnormal_pharynx_morphology1.53646022
26MP0003937_abnormal_limbs/digits/tail_de1.52895873
27MP0001299_abnormal_eye_distance/1.52256079
28MP0004272_abnormal_basement_membrane1.47364860
29MP0005623_abnormal_meninges_morphology1.47323087
30MP0002089_abnormal_postnatal_growth/wei1.46732366
31MP0000778_abnormal_nervous_system1.46118324
32MP0003718_maternal_effect1.36944071
33MP0002160_abnormal_reproductive_system1.36413791
34MP0008438_abnormal_cutaneous_collagen1.36382665
35MP0004133_heterotaxia1.35199266
36MP0002092_abnormal_eye_morphology1.34721695
37MP0002249_abnormal_larynx_morphology1.29835735
38MP0005423_abnormal_somatic_nervous1.29394698
39MP0000462_abnormal_digestive_system1.28760087
40MP0006072_abnormal_retinal_apoptosis1.24344814
41MP0005187_abnormal_penis_morphology1.23434346
42* MP0003861_abnormal_nervous_system1.23311133
43MP0004270_analgesia1.21490291
44MP0009780_abnormal_chondrocyte_physiolo1.20138242
45MP0001119_abnormal_female_reproductive1.17853280
46* MP0003942_abnormal_urinary_system1.17010787
47MP0008995_early_reproductive_senescence1.16921897
48MP0000534_abnormal_ureter_morphology1.16473710
49MP0000432_abnormal_head_morphology1.14591349
50MP0003699_abnormal_female_reproductive1.14484253
51MP0003303_peritoneal_inflammation1.13642056
52MP0003938_abnormal_ear_development1.12188535
53MP0000383_abnormal_hair_follicle1.11942271
54MP0001849_ear_inflammation1.11266007
55MP0004858_abnormal_nervous_system1.10845345
56MP0004885_abnormal_endolymph1.10534128
57MP0000579_abnormal_nail_morphology1.09928705
58MP0005389_reproductive_system_phenotype1.08440489
59MP0003123_paternal_imprinting1.06518676
60MP0009703_decreased_birth_body1.06139923
61MP0002111_abnormal_tail_morphology1.05085404
62MP0003755_abnormal_palate_morphology1.04080000
63MP0003890_abnormal_embryonic-extraembry1.03768634
64MP0000566_synostosis1.03036360
65MP0001984_abnormal_olfaction1.02898889
66MP0010094_abnormal_chromosome_stability1.02674457
67MP0009053_abnormal_anal_canal1.02480431
68MP0009278_abnormal_bone_marrow1.02376691
69MP0009250_abnormal_appendicular_skeleto1.01032974
70MP0005508_abnormal_skeleton_morphology1.00858697
71MP0003111_abnormal_nucleus_morphology1.00674538
72MP0000762_abnormal_tongue_morphology0.99838416
73MP0010030_abnormal_orbit_morphology0.99444725
74MP0001502_abnormal_circadian_rhythm0.99055577
75MP0005257_abnormal_intraocular_pressure0.98869487
76MP0000631_abnormal_neuroendocrine_gland0.98073300
77MP0005409_darkened_coat_color0.97690814
78MP0002084_abnormal_developmental_patter0.97427613
79MP0003329_amyloid_beta_deposits0.96687671
80MP0005076_abnormal_cell_differentiation0.95669143
81MP0000049_abnormal_middle_ear0.95613455
82MP0005551_abnormal_eye_electrophysiolog0.95304297
83MP0002909_abnormal_adrenal_gland0.94727917
84MP0002557_abnormal_social/conspecific_i0.92109519
85MP0003878_abnormal_ear_physiology0.91107931
86MP0005377_hearing/vestibular/ear_phenot0.91107931
87MP0000026_abnormal_inner_ear0.90926787
88* MP0002152_abnormal_brain_morphology0.90848039
89MP0008789_abnormal_olfactory_epithelium0.90610240
90MP0006292_abnormal_olfactory_placode0.89194927
91MP0003119_abnormal_digestive_system0.88699328
92MP0002638_abnormal_pupillary_reflex0.88495366
93MP0002736_abnormal_nociception_after0.87853769
94MP0001346_abnormal_lacrimal_gland0.87559173
95MP0002896_abnormal_bone_mineralization0.87261191
96* MP0003115_abnormal_respiratory_system0.85872882
97MP0005253_abnormal_eye_physiology0.84736885
98MP0002085_abnormal_embryonic_tissue0.83920299
99* MP0002116_abnormal_craniofacial_bone0.83847606
100MP0010386_abnormal_urinary_bladder0.83740994
101MP0002108_abnormal_muscle_morphology0.83602058
102MP0002233_abnormal_nose_morphology0.83435694
103MP0002114_abnormal_axial_skeleton0.83315974
104MP0005646_abnormal_pituitary_gland0.81423057
105MP0001324_abnormal_eye_pigmentation0.81081698
106MP0002752_abnormal_somatic_nervous0.80815385
107MP0005394_taste/olfaction_phenotype0.80749738
108MP0005499_abnormal_olfactory_system0.80749738
109MP0003385_abnormal_body_wall0.80501942
110MP0008058_abnormal_DNA_repair0.79701914
111MP0002132_abnormal_respiratory_system0.79569221
112MP0008932_abnormal_embryonic_tissue0.79450215
113MP0002734_abnormal_mechanical_nocicepti0.79402813
114MP0003315_abnormal_perineum_morphology0.79396460
115MP0002932_abnormal_joint_morphology0.78553290
116MP0005670_abnormal_white_adipose0.78386382
117MP0006276_abnormal_autonomic_nervous0.77651540
118MP0001177_atelectasis0.77103598
119MP0002697_abnormal_eye_size0.76888126
120MP0004859_abnormal_synaptic_plasticity0.76090480
121MP0004233_abnormal_muscle_weight0.75213093
122MP0000013_abnormal_adipose_tissue0.75118670
123MP0003283_abnormal_digestive_organ0.75072949
124MP0002882_abnormal_neuron_morphology0.73755522
125MP0002184_abnormal_innervation0.72737228
126MP0008007_abnormal_cellular_replicative0.71853882
127MP0005391_vision/eye_phenotype0.71465539
128MP0002177_abnormal_outer_ear0.71241281
129MP0003077_abnormal_cell_cycle0.70148548
130MP0001919_abnormal_reproductive_system0.69366666
131MP0005195_abnormal_posterior_eye0.69031691
132MP0003935_abnormal_craniofacial_develop0.68870176
133MP0000955_abnormal_spinal_cord0.67851574
134MP0002127_abnormal_cardiovascular_syste0.67148078
135MP0001270_distended_abdomen0.66155436
136MP0005451_abnormal_body_composition0.65817821
137MP0001286_abnormal_eye_development0.65726121
138MP0000537_abnormal_urethra_morphology0.65553389
139MP0002109_abnormal_limb_morphology0.63688811
140MP0009672_abnormal_birth_weight0.63499858
141MP0003011_delayed_dark_adaptation0.63318395
142MP0000428_abnormal_craniofacial_morphol0.63003676

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.67681893
2Absent/shortened dynein arms (HP:0200106)8.67681893
3Abnormal respiratory motile cilium physiology (HP:0012261)8.35412614
4Rhinitis (HP:0012384)6.80610005
5Abnormal ciliary motility (HP:0012262)6.64771442
6Abnormal respiratory motile cilium morphology (HP:0005938)6.58514436
7Abnormal respiratory epithelium morphology (HP:0012253)6.58514436
8Chronic bronchitis (HP:0004469)6.33628138
9Infertility (HP:0000789)5.06087292
10Nasal polyposis (HP:0100582)4.28408958
11Male infertility (HP:0003251)3.97395873
12Bronchiectasis (HP:0002110)3.89846415
13Nephronophthisis (HP:0000090)3.45168145
14Abnormality of the nasal mucosa (HP:0000433)3.36864730
15Occipital encephalocele (HP:0002085)3.35439280
16Papillary thyroid carcinoma (HP:0002895)3.07699693
17Bronchitis (HP:0012387)3.04300719
18Bell-shaped thorax (HP:0001591)2.89497665
19Abnormality of the renal medulla (HP:0100957)2.81379667
20Abnormality of midbrain morphology (HP:0002418)2.48171318
21Molar tooth sign on MRI (HP:0002419)2.48171318
22High anterior hairline (HP:0009890)2.43606737
23Impulsivity (HP:0100710)2.40113758
24Pancreatic fibrosis (HP:0100732)2.31354992
25Chronic hepatic failure (HP:0100626)2.30489141
26Cervical subluxation (HP:0003308)2.30312447
27True hermaphroditism (HP:0010459)2.28140965
28Protrusio acetabuli (HP:0003179)2.26785986
29Recurrent otitis media (HP:0000403)2.24459731
30Supernumerary spleens (HP:0009799)2.24139961
31Tubulointerstitial abnormality (HP:0001969)2.20175420
32Cystic liver disease (HP:0006706)2.18783230
33Tubulointerstitial fibrosis (HP:0005576)2.16207581
34Fibular hypoplasia (HP:0003038)2.12909046
35Medial flaring of the eyebrow (HP:0010747)2.11391214
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.09911307
37Cholecystitis (HP:0001082)2.09691277
38Abnormal gallbladder physiology (HP:0012438)2.09691277
39Neonatal short-limb short stature (HP:0008921)2.09035005
40Tubulointerstitial nephritis (HP:0001970)2.08396612
41Abnormality of dentin (HP:0010299)2.01100342
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.9828935
43Neoplasm of the heart (HP:0100544)1.99571054
44Turricephaly (HP:0000262)1.98096841
45Cutaneous finger syndactyly (HP:0010554)1.97968164
46Curly hair (HP:0002212)1.97376350
47Postaxial foot polydactyly (HP:0001830)1.95838692
48Taurodontia (HP:0000679)1.92327882
49Abnormality of permanent molar morphology (HP:0011071)1.92327882
50Abnormality of the dental root (HP:0006486)1.92327882
51Broad foot (HP:0001769)1.91326322
52Abnormality of the aortic arch (HP:0012303)1.91144479
53Tubular atrophy (HP:0000092)1.89959240
54Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.89134497
55Vertebral hypoplasia (HP:0008417)1.89134497
56Renal dysplasia (HP:0000110)1.87878956
57Vitreoretinal degeneration (HP:0000655)1.85820444
58Atelectasis (HP:0100750)1.85722676
59Abnormality of molar morphology (HP:0011070)1.83968344
60Abnormality of molar (HP:0011077)1.83968344
61Volvulus (HP:0002580)1.82848086
62Abnormal spermatogenesis (HP:0008669)1.82075090
63Abnormal ventriculo-arterial connection (HP:0011563)1.80302815
64Transposition of the great arteries (HP:0001669)1.80302815
65Abnormal connection of the cardiac segments (HP:0011545)1.80302815
66Pendular nystagmus (HP:0012043)1.78885734
67Congenital hepatic fibrosis (HP:0002612)1.77829624
68Facial cleft (HP:0002006)1.77178449
69Cystic hygroma (HP:0000476)1.76605692
70Bony spicule pigmentary retinopathy (HP:0007737)1.75612152
71Broad distal phalanx of finger (HP:0009836)1.75107748
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.74197399
73Adrenal hypoplasia (HP:0000835)1.72220544
74Cutaneous syndactyly (HP:0012725)1.71448274
75Postaxial hand polydactyly (HP:0001162)1.71129782
76Abnormality of the acetabulum (HP:0003170)1.69926380
77Bile duct proliferation (HP:0001408)1.68922804
78Abnormal biliary tract physiology (HP:0012439)1.68922804
79Oculomotor apraxia (HP:0000657)1.68195329
80Abnormality of the dental pulp (HP:0006479)1.67884823
81Bronchomalacia (HP:0002780)1.67346120
82Hepatoblastoma (HP:0002884)1.67208755
83Broad palm (HP:0001169)1.67001823
84Vertebral arch anomaly (HP:0008438)1.66394158
85Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.66353457
86Back pain (HP:0003418)1.66202205
87Anencephaly (HP:0002323)1.65993927
88Heterotopia (HP:0002282)1.65691114
89Dyschromatopsia (HP:0007641)1.65438087
90Gait imbalance (HP:0002141)1.64861329
91Shawl scrotum (HP:0000049)1.64579421
92Aplasia/Hypoplasia of the fibula (HP:0006492)1.64032137
93Absent frontal sinuses (HP:0002688)1.63894815
94Genital tract atresia (HP:0001827)1.63759378
95Coronal craniosynostosis (HP:0004440)1.63709931
96Midline defect of the nose (HP:0004122)1.63589606
97Shallow orbits (HP:0000586)1.63008904
98Flat acetabular roof (HP:0003180)1.62910682
99Bifid tongue (HP:0010297)1.62480625
100Pancreatic cysts (HP:0001737)1.62180101
101Biconcave vertebral bodies (HP:0004586)1.61830423
102Embryonal neoplasm (HP:0002898)1.61461586
103Testicular neoplasm (HP:0010788)1.61282754
104Vaginal atresia (HP:0000148)1.61130830
105Omphalocele (HP:0001539)1.60610641
106Ependymoma (HP:0002888)1.60496507
107Short nail (HP:0001799)1.60320507
108Germ cell neoplasia (HP:0100728)1.59731912
109Thyroid carcinoma (HP:0002890)1.59140738
110Decreased central vision (HP:0007663)1.58948482
111Renal hypoplasia (HP:0000089)1.58532695
112Trigonocephaly (HP:0000243)1.58245412
113Morphological abnormality of the middle ear (HP:0008609)1.57191971
114Neoplasm of the adrenal cortex (HP:0100641)1.56761268
115Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.56554294
116Absent epiphyses (HP:0010577)1.56554294
117Stage 5 chronic kidney disease (HP:0003774)1.54388989
118Medulloblastoma (HP:0002885)1.53661066
119Gonadal dysgenesis (HP:0000133)1.53658232
120Congenital primary aphakia (HP:0007707)1.53402861
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.53220381
122Absent eyebrow (HP:0002223)1.51914427
123Aplasia/Hypoplasia of the lens (HP:0008063)1.50613504
124Bifid scrotum (HP:0000048)1.50382642
125Oligodactyly (hands) (HP:0001180)1.49862827
126Male pseudohermaphroditism (HP:0000037)1.49604497
127Aplasia involving bones of the upper limbs (HP:0009823)1.49550975
128Aplasia of the phalanges of the hand (HP:0009802)1.49550975
129Aplasia involving bones of the extremities (HP:0009825)1.49550975
130Abnormality of carpal bone ossification (HP:0006257)1.49065443
131Renovascular hypertension (HP:0100817)1.48071262
132Abnormality of the lower motor neuron (HP:0002366)1.48036420
133Dental crowding (HP:0000678)1.47962946
134Decreased testicular size (HP:0008734)1.47924208
13511 pairs of ribs (HP:0000878)1.46373610
136Alacrima (HP:0000522)1.45301499
137Intellectual disability, moderate (HP:0002342)1.45162012
138Abnormality of macular pigmentation (HP:0008002)1.44702126
139Narrow forehead (HP:0000341)1.44287439
140Anophthalmia (HP:0000528)1.42087069
141Recurrent sinusitis (HP:0011108)1.41196062
142Preaxial hand polydactyly (HP:0001177)1.40701836
143Nephrogenic diabetes insipidus (HP:0009806)1.40234123
144Poor coordination (HP:0002370)1.40097026
145Abnormality of the astrocytes (HP:0100707)1.39766910
146Astrocytoma (HP:0009592)1.39766910
147Chorioretinal atrophy (HP:0000533)1.38873288
148Short ribs (HP:0000773)1.37295540
149Holoprosencephaly (HP:0001360)1.34631799
150Breast carcinoma (HP:0003002)1.33077084
151Choroideremia (HP:0001139)1.31976015
152Hypoplasia of the brainstem (HP:0002365)1.30923914
153Aplasia/Hypoplasia of the brainstem (HP:0007362)1.30923914

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.57961173
2PDK34.66567484
3PDK44.66567484
4PRKD34.52513365
5TESK14.27052444
6EEF2K2.85314407
7LATS12.73981992
8CASK2.73922076
9PDK22.70609247
10PNCK2.54642597
11TRIB32.54224574
12NTRK12.31007211
13TTK2.24983637
14BRD42.17426176
15EPHA21.97473872
16PKN21.94470336
17PDGFRA1.93559660
18FGFR21.83037906
19FGFR41.81147256
20MET1.80687759
21MARK11.77627609
22PLK41.67168318
23NEK21.56443725
24LATS21.54565229
25MUSK1.49058491
26TNIK1.45399445
27MAPKAPK31.44916280
28AKT31.43501427
29STK381.42471808
30ERBB41.39778767
31WNK41.38132665
32PTK2B1.38048043
33SIK11.37601735
34NTRK21.37089507
35MKNK21.31872469
36BRAF1.29143727
37DYRK1A1.28548404
38CAMK1G1.27846269
39MST1R1.27837067
40MAP3K61.27706573
41SIK21.24674979
42FGFR11.24464300
43PTK21.24232909
44BCR1.23645973
45EPHB11.23381779
46STK31.23005215
47SMG11.18103102
48CSNK1G31.16703705
49CSNK1A1L1.16197029
50PAK61.15861155
51MAPK131.13914171
52CHEK21.11489307
53DDR21.10457876
54DYRK1B1.10410169
55MAP3K101.09530395
56MAPK151.05504362
57MKNK11.05403680
58STK391.04267367
59TYRO31.03310705
60CSNK1G11.00957576
61STK38L1.00235575
62CDC70.99902042
63CSNK1G20.99508784
64RIPK10.97671161
65DYRK20.96243150
66NME10.94151924
67PBK0.93759384
68NEK60.91693600
69MAP3K70.91452820
70DYRK30.91387965
71EPHA40.90739957
72IRAK10.90298320
73MAP3K90.86079060
74MAP3K40.85777033
75SGK2230.84742731
76SGK4940.84742731
77MAPKAPK50.81716815
78PRKCI0.81245549
79PDGFRB0.78888330
80KSR20.77899889
81PLK10.74961438
82PINK10.74688731
83MARK20.73628047
84TAOK10.70550639
85MTOR0.70428022
86CDK90.66498558
87CDK50.61739169
88SGK20.60684476
89KSR10.59938628
90IRAK20.57549348
91CDK30.57088054
92FGFR30.57078544
93PRKDC0.54281460
94CDC42BPA0.54169872
95AURKA0.53602270
96MOS0.53127502
97RET0.53046293
98ROCK20.52551088
99PRKAA10.51146067
100RPS6KA20.50743312
101CHEK10.49596423
102MAP2K70.48862730
103ATM0.48545681
104WNK10.46133141
105PASK0.45712418
106YES10.44875817
107CDK70.44846531
108PTK60.44330050
109NEK90.43278377
110MAP4K20.41821140
111CDK120.40299297
112TNK20.39058537
113SGK30.39035893
114STK110.38970700
115WEE10.38921050
116FLT30.38610953
117PLK20.38535303
118TAOK20.38219479
119PRKD20.37226874
120PLK30.36960220
121FER0.36830403
122EPHB20.35484300
123FGR0.35450544
124TESK20.34412724
125CAMK1D0.32085735
126PAK10.30831040
127GSK3B0.30310350
128EPHA30.29811736
129CDK10.29706337
130BMPR1B0.28757966
131CDK20.28273040
132LIMK10.27882976
133ROCK10.27814281
134STK100.26192278
135CDK150.26085587
136ERBB30.25901954
137CDK180.25864803
138PAK20.25854891
139CSNK1D0.25282118
140AURKB0.25179948
141ATR0.24630926
142MAPK100.23815841
143CDK80.22920437
144LMTK20.22431134
145NTRK30.22252443
146CAMK2A0.22059102
147CSNK1E0.20289143
148CDK11A0.19198524
149RPS6KA10.19195162
150PRKCZ0.18689614
151RPS6KB10.18579176
152ERBB20.17971561

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043203.73490220
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.84940160
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.33484717
4Histidine metabolism_Homo sapiens_hsa003402.21259641
5Vitamin B6 metabolism_Homo sapiens_hsa007502.20423995
6Linoleic acid metabolism_Homo sapiens_hsa005912.19580527
7Basal transcription factors_Homo sapiens_hsa030222.13684699
8Lysine degradation_Homo sapiens_hsa003102.05695929
9Ether lipid metabolism_Homo sapiens_hsa005652.00779344
10Phototransduction_Homo sapiens_hsa047441.83383955
11Cell cycle_Homo sapiens_hsa041101.83350470
12Oocyte meiosis_Homo sapiens_hsa041141.82610352
13Fanconi anemia pathway_Homo sapiens_hsa034601.80906701
14Endometrial cancer_Homo sapiens_hsa052131.80327959
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.77308290
16mRNA surveillance pathway_Homo sapiens_hsa030151.77281698
17Fatty acid biosynthesis_Homo sapiens_hsa000611.76880172
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.63641664
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.60402991
20beta-Alanine metabolism_Homo sapiens_hsa004101.58721161
21Amphetamine addiction_Homo sapiens_hsa050311.58521027
22ECM-receptor interaction_Homo sapiens_hsa045121.56546384
23Hippo signaling pathway_Homo sapiens_hsa043901.50555350
24ABC transporters_Homo sapiens_hsa020101.50154356
25Cocaine addiction_Homo sapiens_hsa050301.49139316
26Glucagon signaling pathway_Homo sapiens_hsa049221.45528635
27* Basal cell carcinoma_Homo sapiens_hsa052171.45477816
28Steroid biosynthesis_Homo sapiens_hsa001001.45186512
29Phenylalanine metabolism_Homo sapiens_hsa003601.42963490
30Estrogen signaling pathway_Homo sapiens_hsa049151.41543268
31Nicotine addiction_Homo sapiens_hsa050331.40381358
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40297084
33* Hedgehog signaling pathway_Homo sapiens_hsa043401.35134349
34Wnt signaling pathway_Homo sapiens_hsa043101.34314593
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.33918429
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.32029677
37Ovarian steroidogenesis_Homo sapiens_hsa049131.31645297
38RNA degradation_Homo sapiens_hsa030181.31148108
39RNA transport_Homo sapiens_hsa030131.28845068
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28459861
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25521996
42Fatty acid degradation_Homo sapiens_hsa000711.22668365
43Notch signaling pathway_Homo sapiens_hsa043301.22349624
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.21679454
45Fatty acid metabolism_Homo sapiens_hsa012121.20798292
46Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20704808
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19758326
48Complement and coagulation cascades_Homo sapiens_hsa046101.18689332
49Glutamatergic synapse_Homo sapiens_hsa047241.17941526
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16811602
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14395182
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11813251
53Tyrosine metabolism_Homo sapiens_hsa003501.10111663
54Synaptic vesicle cycle_Homo sapiens_hsa047211.07468359
55Long-term potentiation_Homo sapiens_hsa047201.07294262
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07168899
57Renal cell carcinoma_Homo sapiens_hsa052111.06841056
58Circadian rhythm_Homo sapiens_hsa047101.06044373
59Chemical carcinogenesis_Homo sapiens_hsa052041.05770746
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05523306
61Pyruvate metabolism_Homo sapiens_hsa006201.05130235
62Circadian entrainment_Homo sapiens_hsa047131.04631684
63Biosynthesis of amino acids_Homo sapiens_hsa012301.03194102
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01612443
65Insulin secretion_Homo sapiens_hsa049111.01493333
66Arginine and proline metabolism_Homo sapiens_hsa003301.00644699
67Alcoholism_Homo sapiens_hsa050341.00185919
68Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97103776
69Colorectal cancer_Homo sapiens_hsa052100.96385565
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95627132
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95366082
72Taste transduction_Homo sapiens_hsa047420.94087595
73Bile secretion_Homo sapiens_hsa049760.93988525
74GnRH signaling pathway_Homo sapiens_hsa049120.93398595
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92775284
76Choline metabolism in cancer_Homo sapiens_hsa052310.92391569
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92338875
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92240713
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92136058
80Glioma_Homo sapiens_hsa052140.92065036
81Axon guidance_Homo sapiens_hsa043600.90521434
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89942833
83MicroRNAs in cancer_Homo sapiens_hsa052060.88105984
84TGF-beta signaling pathway_Homo sapiens_hsa043500.86436771
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86078001
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84298626
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84216777
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83863263
89Non-homologous end-joining_Homo sapiens_hsa034500.82374739
90Prolactin signaling pathway_Homo sapiens_hsa049170.80797452
91Peroxisome_Homo sapiens_hsa041460.80605518
92Propanoate metabolism_Homo sapiens_hsa006400.80304011
93Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80156659
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77955467
95ErbB signaling pathway_Homo sapiens_hsa040120.77354650
96Prostate cancer_Homo sapiens_hsa052150.76161798
97FoxO signaling pathway_Homo sapiens_hsa040680.75357906
98Huntingtons disease_Homo sapiens_hsa050160.74514828
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73025891
100Glutathione metabolism_Homo sapiens_hsa004800.72669918
101Inositol phosphate metabolism_Homo sapiens_hsa005620.72459213
102Adherens junction_Homo sapiens_hsa045200.72323470
103Dopaminergic synapse_Homo sapiens_hsa047280.71398618
104Type II diabetes mellitus_Homo sapiens_hsa049300.68914417
105Retinol metabolism_Homo sapiens_hsa008300.68835821
106Other glycan degradation_Homo sapiens_hsa005110.68390144
107cAMP signaling pathway_Homo sapiens_hsa040240.66412251
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.65758765
109Protein digestion and absorption_Homo sapiens_hsa049740.64085748
110Purine metabolism_Homo sapiens_hsa002300.63935523
111Fatty acid elongation_Homo sapiens_hsa000620.62377989
112Chronic myeloid leukemia_Homo sapiens_hsa052200.61731139
113Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61232476
114AMPK signaling pathway_Homo sapiens_hsa041520.60957472
115Pancreatic cancer_Homo sapiens_hsa052120.59566267
116Gap junction_Homo sapiens_hsa045400.58842664
117Melanogenesis_Homo sapiens_hsa049160.58687741
118p53 signaling pathway_Homo sapiens_hsa041150.58311441
119Butanoate metabolism_Homo sapiens_hsa006500.58144034
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.58089799
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57257882
122Proteoglycans in cancer_Homo sapiens_hsa052050.57191937
123Olfactory transduction_Homo sapiens_hsa047400.55963980
124Mineral absorption_Homo sapiens_hsa049780.55926037
125Fructose and mannose metabolism_Homo sapiens_hsa000510.55321351
126Tight junction_Homo sapiens_hsa045300.55153808
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54702331
128Focal adhesion_Homo sapiens_hsa045100.53815697
129Dilated cardiomyopathy_Homo sapiens_hsa054140.53249497
130Serotonergic synapse_Homo sapiens_hsa047260.53240856
131Cholinergic synapse_Homo sapiens_hsa047250.52923478
132Ras signaling pathway_Homo sapiens_hsa040140.52822022
133Glycerolipid metabolism_Homo sapiens_hsa005610.52715128
134Cardiac muscle contraction_Homo sapiens_hsa042600.52647390
135Carbon metabolism_Homo sapiens_hsa012000.52542024
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.51922418
137N-Glycan biosynthesis_Homo sapiens_hsa005100.51539077
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.51273606
139VEGF signaling pathway_Homo sapiens_hsa043700.50939069
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50934089
141Base excision repair_Homo sapiens_hsa034100.50369203
142PPAR signaling pathway_Homo sapiens_hsa033200.49145726
143Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48977666
144Non-small cell lung cancer_Homo sapiens_hsa052230.48893573
145mTOR signaling pathway_Homo sapiens_hsa041500.48892767
146Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47004506
147MAPK signaling pathway_Homo sapiens_hsa040100.45458716
148Sphingolipid metabolism_Homo sapiens_hsa006000.44943335
149Insulin signaling pathway_Homo sapiens_hsa049100.44517899
150* Pathways in cancer_Homo sapiens_hsa052000.44282820
151Selenocompound metabolism_Homo sapiens_hsa004500.43808717
152Thyroid hormone synthesis_Homo sapiens_hsa049180.43710955

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