STK38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.05811547
2detection of other organism (GO:0098543)4.54207960
3detection of bacterium (GO:0016045)4.33058186
4negative regulation of lymphocyte mediated immunity (GO:0002707)4.16663890
5regulation of gamma-delta T cell differentiation (GO:0045586)4.01279788
6macrophage activation involved in immune response (GO:0002281)3.95552053
7negative regulation of T cell mediated immunity (GO:0002710)3.89909785
8regulation of gamma-delta T cell activation (GO:0046643)3.89163273
9detection of external biotic stimulus (GO:0098581)3.81859619
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.71892640
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71892640
12activated T cell proliferation (GO:0050798)3.65263705
13negative T cell selection (GO:0043383)3.64080820
14negative regulation of leukocyte mediated immunity (GO:0002704)3.62376423
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.60685014
16negative regulation of cell killing (GO:0031342)3.60685014
17detection of molecule of bacterial origin (GO:0032490)3.55827076
18negative thymic T cell selection (GO:0045060)3.52813577
19regulation of tolerance induction (GO:0002643)3.52728782
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.51363075
21antigen processing and presentation of endogenous antigen (GO:0019883)3.45169889
22positive thymic T cell selection (GO:0045059)3.40427978
23regulation of B cell receptor signaling pathway (GO:0050855)3.34376742
24negative regulation of erythrocyte differentiation (GO:0045647)3.28720890
25microglial cell activation (GO:0001774)3.27593789
26positive regulation of granulocyte differentiation (GO:0030854)3.26493529
27detection of biotic stimulus (GO:0009595)3.24847547
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24642456
29response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.24507153
30response to host (GO:0075136)3.24507153
31response to host defenses (GO:0052200)3.24507153
32respiratory burst (GO:0045730)3.24242223
33response to host immune response (GO:0052572)3.23823830
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.23823830
35leukocyte migration involved in inflammatory response (GO:0002523)3.19696142
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19643420
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15749142
38leukocyte aggregation (GO:0070486)3.14867596
39myeloid cell activation involved in immune response (GO:0002275)3.14381505
40regulation of T cell mediated cytotoxicity (GO:0001914)3.11128773
41positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.10691831
42neutrophil mediated immunity (GO:0002446)3.07462293
43regulation of regulatory T cell differentiation (GO:0045589)3.03445046
44regulation of mast cell degranulation (GO:0043304)3.01749206
45interferon-gamma production (GO:0032609)2.99105187
46macrophage activation (GO:0042116)2.93098611
47regulation of natural killer cell mediated immunity (GO:0002715)2.90753696
48regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.90753696
49dendritic cell migration (GO:0036336)2.90721612
50positive regulation of B cell differentiation (GO:0045579)2.90323058
51positive regulation of T cell mediated cytotoxicity (GO:0001916)2.90144355
52thymic T cell selection (GO:0045061)2.90052074
53positive T cell selection (GO:0043368)2.89511184
54T cell migration (GO:0072678)2.88774029
55regulation of B cell differentiation (GO:0045577)2.88435153
56regulation of necroptotic process (GO:0060544)2.87173116
57leukocyte degranulation (GO:0043299)2.86996843
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86160795
59T cell selection (GO:0045058)2.85493967
60negative regulation of glycoprotein biosynthetic process (GO:0010561)2.84814411
61regulation of leukocyte degranulation (GO:0043300)2.84207708
62regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83966601
63regulation of interleukin-12 biosynthetic process (GO:0045075)2.82901221
64dendritic cell chemotaxis (GO:0002407)2.80369047
65nuclear pore complex assembly (GO:0051292)2.79670657
66negative regulation of T-helper cell differentiation (GO:0045623)2.79244130
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79244130
68negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.78478863
69regulation of mast cell activation involved in immune response (GO:0033006)2.77433009
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77259757
71regulation of dendritic cell antigen processing and presentation (GO:0002604)2.73963885
72myeloid leukocyte mediated immunity (GO:0002444)2.73201785
73NIK/NF-kappaB signaling (GO:0038061)2.70529553
74meiotic chromosome segregation (GO:0045132)2.69815589
75regulation of helicase activity (GO:0051095)2.66413117
76nuclear pore organization (GO:0006999)2.65458644
77response to interleukin-15 (GO:0070672)2.60134029
78immunoglobulin mediated immune response (GO:0016064)2.58572103
79regulation of histone H3-K27 methylation (GO:0061085)2.58151655
80negative regulation of interleukin-12 production (GO:0032695)2.57262098
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.53909105
82B cell receptor signaling pathway (GO:0050853)2.53762447
83regulation of mitotic spindle organization (GO:0060236)2.51409298
84B cell mediated immunity (GO:0019724)2.48499495
85regulation of response to interferon-gamma (GO:0060330)2.47757411
86negative regulation of histone methylation (GO:0031061)2.47250376
87regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46568054
88mitotic chromosome condensation (GO:0007076)2.43590870
89regulation of alpha-beta T cell proliferation (GO:0046640)2.42806301
90regulation of T cell tolerance induction (GO:0002664)2.41730572
91protein localization to kinetochore (GO:0034501)2.41165942
92positive regulation of interferon-alpha production (GO:0032727)2.40959178
93regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.40644165
94regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39899015
95pore complex assembly (GO:0046931)2.39279238
96regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.37561741
97modulation by symbiont of host defense response (GO:0052031)2.37404033
98modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.37404033
99modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.37404033
100positive regulation by organism of defense response of other organism involved in symbiotic interact2.37404033
101modulation by symbiont of host immune response (GO:0052553)2.37404033
102positive regulation by symbiont of host defense response (GO:0052509)2.37404033
103leukocyte cell-cell adhesion (GO:0007159)2.37374673
104negative regulation of phagocytosis (GO:0050765)2.37022666
105regulation of spindle organization (GO:0090224)2.36988055
106neutrophil activation (GO:0042119)2.35625374
107regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35123298
108B cell homeostasis (GO:0001782)2.32784219
109DNA geometric change (GO:0032392)2.32604947
110DNA duplex unwinding (GO:0032508)2.30346802
111antigen receptor-mediated signaling pathway (GO:0050851)2.29291449
112tolerance induction (GO:0002507)2.27366321
113positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.27105206
114antigen processing and presentation via MHC class Ib (GO:0002475)2.27000366
115cellular response to interleukin-15 (GO:0071350)2.26838955
116regulation of interferon-alpha production (GO:0032647)2.24173397
117positive regulation of isotype switching (GO:0045830)2.23782958
118T cell receptor signaling pathway (GO:0050852)2.23764300
119histone H3-K4 trimethylation (GO:0080182)2.23337487
120kinetochore organization (GO:0051383)2.23067875
121lymphocyte homeostasis (GO:0002260)2.22803220
122negative regulation of granulocyte differentiation (GO:0030853)2.22659094
123hepatocyte apoptotic process (GO:0097284)2.22506071
124positive regulation of interferon-beta production (GO:0032728)2.22325259
125response to type I interferon (GO:0034340)2.22187033
126mitotic nuclear envelope disassembly (GO:0007077)2.21680872
127histone mRNA catabolic process (GO:0071044)2.21365897
128mitotic metaphase plate congression (GO:0007080)2.20295675
129protein localization to chromosome, centromeric region (GO:0071459)2.20149754
130pinocytosis (GO:0006907)2.19536465
131neutrophil activation involved in immune response (GO:0002283)2.17401993
132histone H3-K4 methylation (GO:0051568)2.16327839
133response to peptidoglycan (GO:0032494)2.15920128
134type I interferon signaling pathway (GO:0060337)2.15696105
135cellular response to type I interferon (GO:0071357)2.15696105
136mitotic sister chromatid cohesion (GO:0007064)2.15130344
137regulation of T cell receptor signaling pathway (GO:0050856)2.12851431
138T cell costimulation (GO:0031295)2.12694662
139cellular extravasation (GO:0045123)2.12668702
140positive regulation of tolerance induction (GO:0002645)2.12401388
141granulocyte activation (GO:0036230)2.11658162
142metaphase plate congression (GO:0051310)2.11017135
143response to muramyl dipeptide (GO:0032495)2.10995254
144dosage compensation (GO:0007549)2.10730878
145positive regulation of antigen processing and presentation (GO:0002579)2.10177917
146regulation of interferon-beta biosynthetic process (GO:0045357)2.10008447
147establishment of chromosome localization (GO:0051303)2.08064750

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37655875
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.84649548
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75188151
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.63598802
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.27520497
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88016569
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.83021931
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64264801
9MYC_22102868_ChIP-Seq_BL_Human2.62461949
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.60769234
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38458993
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33888327
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.30557038
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.24217945
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16991348
16VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05900074
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05066656
18* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97567373
19IRF8_27001747_Chip-Seq_BMDM_Mouse1.96305571
20MYB_26560356_Chip-Seq_TH2_Human1.96254771
21* MYB_26560356_Chip-Seq_TH1_Human1.96081237
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96029392
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94371027
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93322616
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.92298404
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91994488
27VDR_21846776_ChIP-Seq_THP-1_Human1.88814657
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87938388
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84949277
30* SPI1_23547873_ChIP-Seq_NB4_Human1.83097468
31MAF_26560356_Chip-Seq_TH1_Human1.83055374
32SCL_19346495_ChIP-Seq_HPC-7_Human1.81956868
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74107999
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73556220
35RUNX_20019798_ChIP-Seq_JUKART_Human1.72102541
36UTX_26944678_Chip-Seq_JUKART_Human1.67840059
37VDR_24787735_ChIP-Seq_THP-1_Human1.66396200
38* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.59176103
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57521830
40GATA1_19941827_ChIP-Seq_MEL_Mouse1.54250150
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52981838
42E2F1_21310950_ChIP-Seq_MCF-7_Human1.48749652
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.48122497
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.47062875
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.40356687
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.39961913
47* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39418381
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38707513
49CIITA_25753668_ChIP-Seq_RAJI_Human1.37988916
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37142491
51TCF7_22412390_ChIP-Seq_EML_Mouse1.35587378
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34686328
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.34117297
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.33596865
55* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32780056
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32189977
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30520558
58GATA1_19941826_ChIP-Seq_K562_Human1.29221589
59MYC_18555785_ChIP-Seq_MESCs_Mouse1.27508270
60* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26626093
61VDR_24763502_ChIP-Seq_THP-1_Human1.25113162
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23056789
63GATA3_26560356_Chip-Seq_TH2_Human1.22262627
64* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21547347
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21335462
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19927510
67MAF_26560356_Chip-Seq_TH2_Human1.19591345
68KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17763793
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17466144
70AR_21909140_ChIP-Seq_LNCAP_Human1.16857260
71EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15634549
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15421765
73GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15092244
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13555572
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12074442
76MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11568531
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.11446561
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.10892581
79PU_27001747_Chip-Seq_BMDM_Mouse1.10581297
80STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10522911
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10239145
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10068777
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09931561
84GATA2_19941826_ChIP-Seq_K562_Human1.09096627
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08722373
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07488942
87* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07253104
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.07130971
89* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06705441
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06662704
91NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05976357
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04722824
93Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04700931
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04656713
95* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.02964128
96* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02839338
97MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02684969
98VDR_23849224_ChIP-Seq_CD4+_Human1.02604798
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.02588710
100GATA3_27048872_Chip-Seq_THYMUS_Human1.02132451
101TFEB_21752829_ChIP-Seq_HELA_Human1.01868666
102SPI1_23127762_ChIP-Seq_K562_Human1.01544904
103FOXP3_21729870_ChIP-Seq_TREG_Human1.01042458
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00492193
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00137689
106SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99066015
107CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98900986
108KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98446692
109* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97930639
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97494850
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96003323
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95292129
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95292129
114KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95292129
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94509101
116KDM5A_27292631_Chip-Seq_BREAST_Human0.94224249
117ELK3_25401928_ChIP-Seq_HUVEC_Human0.93972141
118* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93823610
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92410910
120RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92263329
121* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90663511
122NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90527441
123GATA1_22025678_ChIP-Seq_K562_Human0.89288311
124CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89254242
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.88809706
126LXR_22292898_ChIP-Seq_THP-1_Human0.88768436
127ELK1_19687146_ChIP-ChIP_HELA_Human0.88656515
128TP63_17297297_ChIP-ChIP_HaCaT_Human0.88575308
129TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88314399
130NCOR1_26117541_ChIP-Seq_K562_Human0.88197815
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87669047
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.86947558
133PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85226733
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84543098
135TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83683708
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82359596
137KDM2B_26808549_Chip-Seq_DND41_Human0.80682928
138RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80656089
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.80382122
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78423349
141RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.76715114

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation2.77921252
2MP0003763_abnormal_thymus_physiology2.74056000
3MP0008260_abnormal_autophagy2.50378753
4MP0000685_abnormal_immune_system2.42647588
5MP0001800_abnormal_humoral_immune2.36235665
6MP0002396_abnormal_hematopoietic_system2.31510208
7MP0003693_abnormal_embryo_hatching2.31003625
8MP0003436_decreased_susceptibility_to2.26402373
9MP0008057_abnormal_DNA_replication2.08143766
10MP0005387_immune_system_phenotype2.06961311
11MP0001790_abnormal_immune_system2.06961311
12MP0003111_abnormal_nucleus_morphology2.04538591
13MP0002452_abnormal_antigen_presenting2.03490045
14MP0005671_abnormal_response_to2.03139010
15MP0010094_abnormal_chromosome_stability1.99294287
16MP0009278_abnormal_bone_marrow1.96292301
17MP0000569_abnormal_digit_pigmentation1.95197685
18MP0002166_altered_tumor_susceptibility1.93332496
19MP0003828_pulmonary_edema1.93216210
20MP0002398_abnormal_bone_marrow1.92674488
21MP0002420_abnormal_adaptive_immunity1.90792418
22MP0001819_abnormal_immune_cell1.89323445
23MP0002723_abnormal_immune_serum1.88600526
24MP0005000_abnormal_immune_tolerance1.88075532
25MP0009785_altered_susceptibility_to1.85799310
26MP0003077_abnormal_cell_cycle1.84279083
27MP0010352_gastrointestinal_tract_polyps1.80180613
28MP0005025_abnormal_response_to1.79475478
29MP0002419_abnormal_innate_immunity1.76981220
30MP0009333_abnormal_splenocyte_physiolog1.72863341
31MP0002006_tumorigenesis1.72755315
32MP0000689_abnormal_spleen_morphology1.72176685
33MP0000716_abnormal_immune_system1.68486703
34MP0002405_respiratory_system_inflammati1.68164292
35MP0004883_abnormal_blood_vessel1.66710509
36MP0002722_abnormal_immune_system1.64510519
37MP0010155_abnormal_intestine_physiology1.63094354
38MP0001851_eye_inflammation1.61247016
39MP0001545_abnormal_hematopoietic_system1.59250492
40MP0005397_hematopoietic_system_phenotyp1.59250492
41MP0004947_skin_inflammation1.57541059
42MP0008058_abnormal_DNA_repair1.55985388
43MP0000703_abnormal_thymus_morphology1.55857305
44MP0004808_abnormal_hematopoietic_stem1.53433580
45MP0001873_stomach_inflammation1.50350401
46MP0005464_abnormal_platelet_physiology1.49486383
47MP0005451_abnormal_body_composition1.48284814
48MP0002429_abnormal_blood_cell1.45898840
49MP0000858_altered_metastatic_potential1.44458267
50MP0000490_abnormal_crypts_of1.41301509
51MP0005174_abnormal_tail_pigmentation1.37477849
52MP0002148_abnormal_hypersensitivity_rea1.36851490
53MP0001853_heart_inflammation1.33639536
54MP0010307_abnormal_tumor_latency1.33553970
55MP0003303_peritoneal_inflammation1.33259780
56MP0003183_abnormal_peptide_metabolism1.32397856
57MP0005164_abnormal_response_to1.32068024
58MP0003448_altered_tumor_morphology1.29624221
59MP0006082_CNS_inflammation1.29484130
60MP0003300_gastrointestinal_ulcer1.28824512
61MP0005076_abnormal_cell_differentiation1.28679513
62MP0001845_abnormal_inflammatory_respons1.27645470
63MP0004957_abnormal_blastocyst_morpholog1.27247100
64MP0003091_abnormal_cell_migration1.26008101
65MP0002998_abnormal_bone_remodeling1.25302955
66MP0008007_abnormal_cellular_replicative1.23233184
67MP0003705_abnormal_hypodermis_morpholog1.23225922
68MP0002019_abnormal_tumor_incidence1.21465099
69MP0005075_abnormal_melanosome_morpholog1.19999397
70MP0003566_abnormal_cell_adhesion1.19462472
71MP0003724_increased_susceptibility_to1.17742857
72MP0005023_abnormal_wound_healing1.14583365
73MP0001958_emphysema1.09703106
74MP0005310_abnormal_salivary_gland1.08141831
75MP0002132_abnormal_respiratory_system1.06961090
76MP0000465_gastrointestinal_hemorrhage1.05917823
77MP0000371_diluted_coat_color1.03938926
78MP0006054_spinal_hemorrhage1.03846670
79MP0000350_abnormal_cell_proliferation1.01769216
80MP0003453_abnormal_keratinocyte_physiol1.00437395
81MP0004130_abnormal_muscle_cell0.98577233
82MP0001663_abnormal_digestive_system0.97832423
83MP0003279_aneurysm0.96254074
84MP0002933_joint_inflammation0.95435791
85MP0002277_abnormal_respiratory_mucosa0.95077136
86MP0008469_abnormal_protein_level0.94566426
87MP0001533_abnormal_skeleton_physiology0.89733217
88MP0003656_abnormal_erythrocyte_physiolo0.88551413
89MP0009764_decreased_sensitivity_to0.88213960
90MP0005390_skeleton_phenotype0.88203516
91MP0000015_abnormal_ear_pigmentation0.87507306
92MP0005083_abnormal_biliary_tract0.87170319
93MP0003172_abnormal_lysosome_physiology0.86149565
94MP0000249_abnormal_blood_vessel0.86116864
95MP0002009_preneoplasia0.85673458
96MP0000609_abnormal_liver_physiology0.85486972
97MP0009763_increased_sensitivity_to0.85295446
98MP0003221_abnormal_cardiomyocyte_apopto0.85170718
99MP0005166_decreased_susceptibility_to0.83036927
100MP0008004_abnormal_stomach_pH0.83019615
101MP0000313_abnormal_cell_death0.81185079
102MP0005409_darkened_coat_color0.80073550
103MP0004510_myositis0.79885053
104MP0003866_abnormal_defecation0.79380316
105MP0004381_abnormal_hair_follicle0.79323207
106MP0004264_abnormal_extraembryonic_tissu0.76776994
107MP0002086_abnormal_extraembryonic_tissu0.75747676
108MP0003045_fibrosis0.75398348
109MP0003191_abnormal_cellular_cholesterol0.75387372
110MP0001672_abnormal_embryogenesis/_devel0.75183815
111MP0005380_embryogenesis_phenotype0.75183815
112MP0003690_abnormal_glial_cell0.73502681
113MP0000598_abnormal_liver_morphology0.72052790
114MP0000343_altered_response_to0.71932747
115MP0005058_abnormal_lysosome_morphology0.71561628
116MP0003795_abnormal_bone_structure0.71304004
117MP0002138_abnormal_hepatobiliary_system0.71022821
118MP0003984_embryonic_growth_retardation0.70615668
119MP0004197_abnormal_fetal_growth/weight/0.70569638
120MP0009840_abnormal_foam_cell0.69930667
121MP0003786_premature_aging0.69867075
122MP0002088_abnormal_embryonic_growth/wei0.69582705
123MP0000477_abnormal_intestine_morphology0.69519069
124MP0000733_abnormal_muscle_development0.69418327
125MP0001986_abnormal_taste_sensitivity0.68501223
126MP0005365_abnormal_bile_salt0.68304836
127MP0000604_amyloidosis0.68219908
128MP0005670_abnormal_white_adipose0.67848848
129MP0009765_abnormal_xenobiotic_induced0.67571416
130MP0001730_embryonic_growth_arrest0.66737550
131MP0001243_abnormal_dermal_layer0.65114310
132MP0002133_abnormal_respiratory_system0.63640211
133MP0005388_respiratory_system_phenotype0.63640211

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.02338741
2Optic neuritis (HP:0100653)4.02338741
3Recurrent abscess formation (HP:0002722)3.92152588
4Gastrointestinal infarctions (HP:0005244)3.81743790
5Autoimmune thrombocytopenia (HP:0001973)3.78410146
6Pustule (HP:0200039)3.72993532
7Eczematoid dermatitis (HP:0000976)3.72851534
8T lymphocytopenia (HP:0005403)3.63667831
9Abnormality of T cell number (HP:0011839)3.53553913
10Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52416212
11Recurrent bacterial skin infections (HP:0005406)3.49545964
12Chromsome breakage (HP:0040012)3.45636110
13Abnormality of the fingertips (HP:0001211)3.33325194
14Recurrent viral infections (HP:0004429)3.31878222
15Recurrent fungal infections (HP:0002841)3.25791281
16Peritonitis (HP:0002586)3.22784213
17Keratoconjunctivitis sicca (HP:0001097)3.03020349
18Combined immunodeficiency (HP:0005387)2.97504561
19Chest pain (HP:0100749)2.92661118
20Stomatitis (HP:0010280)2.90162083
21Abnormality of T cells (HP:0002843)2.89486217
22Eosinophilia (HP:0001880)2.82602996
23Elevated erythrocyte sedimentation rate (HP:0003565)2.79569669
24Urticaria (HP:0001025)2.76884718
25Keratoconjunctivitis (HP:0001096)2.75888693
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71659032
27Mediastinal lymphadenopathy (HP:0100721)2.68857340
28Granulocytopenia (HP:0001913)2.68681030
29Recurrent gram-negative bacterial infections (HP:0005420)2.67323149
30Severe combined immunodeficiency (HP:0004430)2.66121201
31Pulmonary infiltrates (HP:0002113)2.65417935
32Periodontitis (HP:0000704)2.64516559
33IgM deficiency (HP:0002850)2.63128814
34Abnormality of chromosome stability (HP:0003220)2.52754926
35Papilledema (HP:0001085)2.51347531
36Leukocytosis (HP:0001974)2.51204602
37Abnormality of DNA repair (HP:0003254)2.50304267
38Myositis (HP:0100614)2.48914086
39Increased IgM level (HP:0003496)2.47856678
40Recurrent bronchitis (HP:0002837)2.47840116
41Abnormality of eosinophils (HP:0001879)2.47399753
42Hemoptysis (HP:0002105)2.46600355
43Arterial thrombosis (HP:0004420)2.44381276
44Gingivitis (HP:0000230)2.44333611
45Hypochromic microcytic anemia (HP:0004840)2.44045082
46Panhypogammaglobulinemia (HP:0003139)2.42844278
47Clubbing of toes (HP:0100760)2.40943064
48B lymphocytopenia (HP:0010976)2.31682140
49Abnormality of B cell number (HP:0010975)2.31682140
50Recurrent skin infections (HP:0001581)2.31056850
51Chronic mucocutaneous candidiasis (HP:0002728)2.30095750
52Recurrent cutaneous fungal infections (HP:0011370)2.30095750
53Meckel diverticulum (HP:0002245)2.29858642
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.29305705
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.25773105
56Subacute progressive viral hepatitis (HP:0006572)2.25432513
57Thyroiditis (HP:0100646)2.23882716
58Slow saccadic eye movements (HP:0000514)2.21156152
59Petechiae (HP:0000967)2.20515122
60Abnormality of the preputium (HP:0100587)2.20225856
61Episodic fever (HP:0001954)2.18647424
62Abnormality of the ileum (HP:0001549)2.18164657
63Ectopic kidney (HP:0000086)2.17489189
64Basal cell carcinoma (HP:0002671)2.16468133
65Anorexia (HP:0002039)2.16287416
66Amyloidosis (HP:0011034)2.16123885
67Agnosia (HP:0010524)2.15567363
68Chronic otitis media (HP:0000389)2.15336859
69Hypergammaglobulinemia (HP:0010702)2.14827774
70Abnormality of T cell physiology (HP:0011840)2.14380621
71Viral hepatitis (HP:0006562)2.13914414
72Abnormality of the peritoneum (HP:0002585)2.13487824
73Meningitis (HP:0001287)2.12983566
74Lymphopenia (HP:0001888)2.12892042
75Pulmonary embolism (HP:0002204)2.12775986
76Myelodysplasia (HP:0002863)2.12522155
77Abnormality of macrophages (HP:0004311)2.10812818
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.10526324
79Prolonged bleeding time (HP:0003010)2.07960623
80Agammaglobulinemia (HP:0004432)2.05908537
81Dilatation of the ascending aorta (HP:0005111)2.05104395
82Spontaneous hematomas (HP:0007420)2.03999937
83Lymphoma (HP:0002665)2.03068748
84Autoimmune hemolytic anemia (HP:0001890)2.01327134
85Sepsis (HP:0100806)1.99443538
86Microcytic anemia (HP:0001935)1.99438394
87IgG deficiency (HP:0004315)1.99080181
88Cellulitis (HP:0100658)1.98550928
89Inflammation of the large intestine (HP:0002037)1.98511196
90Glomerulopathy (HP:0100820)1.97841505
91Increased mean platelet volume (HP:0011877)1.97490449
92Nasal polyposis (HP:0100582)1.97117178
93Leukopenia (HP:0001882)1.96242733
94Abnormality of pyrimidine metabolism (HP:0004353)1.96140549
95Verrucae (HP:0200043)1.94892609
96Papilloma (HP:0012740)1.94892609
97Gastrointestinal inflammation (HP:0004386)1.94008536
98Chronic obstructive pulmonary disease (HP:0006510)1.93499521
99Obstructive lung disease (HP:0006536)1.93499521
100Vasculitis (HP:0002633)1.93132328
101Purpura (HP:0000979)1.92642941
102Gingival bleeding (HP:0000225)1.92126468
103Spondylolisthesis (HP:0003302)1.90852499
104Chronic diarrhea (HP:0002028)1.89557286
105IgA deficiency (HP:0002720)1.87892263
106Myocardial infarction (HP:0001658)1.85697095
107Cheilitis (HP:0100825)1.84361510
108Orchitis (HP:0100796)1.83811911
109Anal stenosis (HP:0002025)1.82025037
110Thrombocytosis (HP:0001894)1.81280368
111Epistaxis (HP:0000421)1.81019638
112Aortic aneurysm (HP:0004942)1.79891019
113Abnormality of the pleura (HP:0002103)1.79357756
114Gangrene (HP:0100758)1.78720749
115Lip pit (HP:0100267)1.78052130
116Osteomyelitis (HP:0002754)1.77527032
117Poikiloderma (HP:0001029)1.77487141
118Ependymoma (HP:0002888)1.77443934
119Menorrhagia (HP:0000132)1.76659786
120Abnormality of the prostate (HP:0008775)1.76353143
121Abnormal platelet volume (HP:0011876)1.76257875
122Long eyelashes (HP:0000527)1.74799489
123Hypochromic anemia (HP:0001931)1.74699654
124Skin ulcer (HP:0200042)1.74639769
125Entropion (HP:0000621)1.74051990
126Fatigue (HP:0012378)1.73349839
127Colitis (HP:0002583)1.73263405
128Arterial tortuosity (HP:0005116)1.72548168
129Metaphyseal cupping (HP:0003021)1.72294226
130Medulloblastoma (HP:0002885)1.71551195
131Bone marrow hypocellularity (HP:0005528)1.71475012
132Abnormality of the endocardium (HP:0004306)1.71434512
133Hypoplasia of the thymus (HP:0000778)1.71327063
134Encephalitis (HP:0002383)1.71220591
135Interstitial pulmonary disease (HP:0006530)1.70301735
136Hematochezia (HP:0002573)1.68169637
137Reticulocytopenia (HP:0001896)1.68121924
138Abnormality of the nasal mucosa (HP:0000433)1.67844021
139Amaurosis fugax (HP:0100576)1.67618400
140Abnormality of the carotid arteries (HP:0005344)1.65021292
141Increased IgE level (HP:0003212)1.64290151
142Recurrent sinusitis (HP:0011108)1.64025940
143Small intestinal stenosis (HP:0012848)1.62473777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.07532976
2MAP4K13.45747800
3CDK122.74087619
4PRPF4B2.61665993
5STK102.41531172
6FES2.38544899
7MAP3K142.37512899
8TXK2.34915615
9TYK22.33843776
10IRAK42.19348960
11EPHB12.16639198
12JAK32.11290699
13IRAK32.09807064
14RPS6KA41.94590727
15PKN21.88514282
16FGFR41.84319832
17ZAP701.78551294
18SIK31.77628147
19NEK21.77390690
20MAP2K31.65696391
21ITK1.63254791
22MAP3K101.63082976
23IKBKE1.59868893
24MAP3K131.58534942
25CSK1.58217311
26ERN11.53331242
27FGR1.52583694
28GRK61.50746604
29SRPK11.47098004
30BRD41.46742409
31TNK21.44142004
32EEF2K1.43506602
33TRIB31.43497793
34JAK11.43158135
35CDK61.42190113
36CDK41.41331197
37BLK1.41284654
38KIT1.40074027
39BTK1.39339431
40FGFR31.36740051
41IKBKB1.33800195
42PIM11.33214708
43TEC1.32995585
44CSF1R1.32103949
45TBK11.23597498
46CHUK1.22994367
47NLK1.22955017
48FLT31.21845121
49MAP3K61.20646763
50MARK21.17976167
51HCK1.17202019
52TGFBR21.16357067
53CDC71.12480024
54ATR1.11635658
55LCK1.05767304
56TAOK11.02414318
57KSR21.02408284
58MARK31.00825995
59MAP3K10.98296872
60MAP3K20.96233772
61TTN0.94582476
62PTK2B0.90686693
63WEE10.90164642
64PLK40.89583016
65TTK0.87382028
66CDK70.87329100
67SYK0.87089188
68BMPR20.86704062
69MAP3K110.86475298
70LRRK20.86411878
71TRPM70.86309738
72CAMK1D0.84125998
73CAMKK20.83634621
74PIK3CG0.81251858
75STK30.80734989
76ZAK0.80617283
77PDK10.80589951
78CDC42BPA0.79724868
79SIK10.78158488
80PLK10.78070032
81SMG10.77648868
82DYRK1B0.77207072
83PRKD20.76669733
84CLK10.76561052
85AURKB0.76458454
86RPS6KB20.75909832
87NUAK10.75786041
88TAOK30.75442580
89CHEK20.75103656
90PTK60.75072385
91YES10.72714752
92MAP3K30.71097259
93HIPK20.70865248
94MAPK110.70213967
95JAK20.69964630
96NEK90.68586204
97LYN0.68319959
98IRAK10.66982410
99PDPK10.66628763
100RET0.66086285
101CAMKK10.65955437
102FYN0.65714357
103SIK20.65352998
104BUB10.64552822
105* STK40.62128671
106MTOR0.60792387
107RIPK10.58989688
108SGK30.58933699
109EIF2AK20.57314082
110MELK0.57124549
111EPHA20.57117211
112CHEK10.57004228
113ATM0.56953133
114TESK20.56541568
115MAP3K80.56432908
116LATS10.54818153
117EIF2AK10.53955461
118WNK10.53797392
119MAP3K70.53555432
120MAPK120.52713924
121PRKCQ0.52238873
122TAOK20.50989811
123PASK0.49902681
124MKNK20.49640129
125CDK90.49445659
126EPHA30.46922918
127MATK0.46466845
128KSR10.45252612
129RAF10.44283633
130MAP3K50.43712996
131EIF2AK30.43482093
132KDR0.43478466
133PAK40.42860965
134MAPK70.42370321
135BMX0.42190879
136ABL10.41925692
137BRSK20.41788606
138MAPKAPK20.41682065
139DYRK30.41348895
140RPS6KC10.40268598
141RPS6KL10.40268598
142CDK20.40093955
143STK110.39786180
144PDGFRB0.39477668
145IRAK20.39398766

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.09201395
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.36521841
3Mismatch repair_Homo sapiens_hsa034302.06401693
4Measles_Homo sapiens_hsa051621.96225929
5Leishmaniasis_Homo sapiens_hsa051401.92090500
6DNA replication_Homo sapiens_hsa030301.90364008
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.89882083
8Staphylococcus aureus infection_Homo sapiens_hsa051501.80103136
9Herpes simplex infection_Homo sapiens_hsa051681.78477766
10Non-homologous end-joining_Homo sapiens_hsa034501.77201655
11Fanconi anemia pathway_Homo sapiens_hsa034601.71452611
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.62671260
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62387858
14Base excision repair_Homo sapiens_hsa034101.61743661
15B cell receptor signaling pathway_Homo sapiens_hsa046621.61301962
16Antigen processing and presentation_Homo sapiens_hsa046121.55438529
17T cell receptor signaling pathway_Homo sapiens_hsa046601.54137280
18Osteoclast differentiation_Homo sapiens_hsa043801.53869082
19Hematopoietic cell lineage_Homo sapiens_hsa046401.53030714
20p53 signaling pathway_Homo sapiens_hsa041151.52639379
21One carbon pool by folate_Homo sapiens_hsa006701.48645798
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47048518
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44587964
24Homologous recombination_Homo sapiens_hsa034401.42293011
25Caffeine metabolism_Homo sapiens_hsa002321.42098006
26Cell cycle_Homo sapiens_hsa041101.41911497
27Lysine degradation_Homo sapiens_hsa003101.37096850
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.36566840
29Influenza A_Homo sapiens_hsa051641.35846103
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.28674537
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27395412
32Spliceosome_Homo sapiens_hsa030401.26915547
33Acute myeloid leukemia_Homo sapiens_hsa052211.21914411
34Graft-versus-host disease_Homo sapiens_hsa053321.21033732
35Other glycan degradation_Homo sapiens_hsa005111.19326268
36Jak-STAT signaling pathway_Homo sapiens_hsa046301.17655946
37Toxoplasmosis_Homo sapiens_hsa051451.17277084
38Apoptosis_Homo sapiens_hsa042101.14831645
39Renal cell carcinoma_Homo sapiens_hsa052111.13528192
40Small cell lung cancer_Homo sapiens_hsa052221.09856567
41Notch signaling pathway_Homo sapiens_hsa043301.09108157
42Type I diabetes mellitus_Homo sapiens_hsa049401.08437178
43Endometrial cancer_Homo sapiens_hsa052131.07938511
44VEGF signaling pathway_Homo sapiens_hsa043701.06901384
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.06850031
46Phagosome_Homo sapiens_hsa041451.06420048
47Legionellosis_Homo sapiens_hsa051341.05823691
48Hepatitis B_Homo sapiens_hsa051611.05171578
49Chronic myeloid leukemia_Homo sapiens_hsa052201.04926876
50Viral myocarditis_Homo sapiens_hsa054161.04378675
51Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03742668
52Nucleotide excision repair_Homo sapiens_hsa034201.03720180
53RNA transport_Homo sapiens_hsa030131.02446960
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00541171
55HTLV-I infection_Homo sapiens_hsa051660.99124500
56Epstein-Barr virus infection_Homo sapiens_hsa051690.96757467
57TNF signaling pathway_Homo sapiens_hsa046680.96688346
58mRNA surveillance pathway_Homo sapiens_hsa030150.95555096
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.94631949
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94604229
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.94405697
62Endocytosis_Homo sapiens_hsa041440.93181833
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90153664
64Choline metabolism in cancer_Homo sapiens_hsa052310.89781988
65Pancreatic cancer_Homo sapiens_hsa052120.89004215
66Hepatitis C_Homo sapiens_hsa051600.88417340
67RNA degradation_Homo sapiens_hsa030180.87369500
68Shigellosis_Homo sapiens_hsa051310.85705673
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.85226605
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.84902664
71Tuberculosis_Homo sapiens_hsa051520.84361341
72Viral carcinogenesis_Homo sapiens_hsa052030.84183536
73Salmonella infection_Homo sapiens_hsa051320.84174742
74MicroRNAs in cancer_Homo sapiens_hsa052060.82897668
75Thyroid cancer_Homo sapiens_hsa052160.82460211
76Pertussis_Homo sapiens_hsa051330.82388054
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82022543
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.81778888
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.81547308
80Amoebiasis_Homo sapiens_hsa051460.80615330
81Inositol phosphate metabolism_Homo sapiens_hsa005620.79854899
82African trypanosomiasis_Homo sapiens_hsa051430.79508700
83Allograft rejection_Homo sapiens_hsa053300.79270245
84Malaria_Homo sapiens_hsa051440.78933521
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78291143
86Dorso-ventral axis formation_Homo sapiens_hsa043200.78204826
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.75803841
88Selenocompound metabolism_Homo sapiens_hsa004500.73746066
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73343087
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73210079
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71300450
92Colorectal cancer_Homo sapiens_hsa052100.70574334
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69966201
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69953388
95ErbB signaling pathway_Homo sapiens_hsa040120.69054369
96ABC transporters_Homo sapiens_hsa020100.66202096
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65909379
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65464851
99Complement and coagulation cascades_Homo sapiens_hsa046100.64596984
100Chemokine signaling pathway_Homo sapiens_hsa040620.64439662
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63651985
102Asthma_Homo sapiens_hsa053100.63567611
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62660858
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62077172
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60943701
106GnRH signaling pathway_Homo sapiens_hsa049120.60112565
107Adherens junction_Homo sapiens_hsa045200.59215882
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.58465330
109FoxO signaling pathway_Homo sapiens_hsa040680.58213701
110Insulin resistance_Homo sapiens_hsa049310.58008129
111Focal adhesion_Homo sapiens_hsa045100.56866211
112Pyrimidine metabolism_Homo sapiens_hsa002400.55777965
113HIF-1 signaling pathway_Homo sapiens_hsa040660.54443263
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54139475
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54014645
116Autoimmune thyroid disease_Homo sapiens_hsa053200.52496101
117Rap1 signaling pathway_Homo sapiens_hsa040150.51829378
118Glioma_Homo sapiens_hsa052140.51328817
119Platelet activation_Homo sapiens_hsa046110.50901492
120Pentose phosphate pathway_Homo sapiens_hsa000300.50270120
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48753273
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47674165
123Prostate cancer_Homo sapiens_hsa052150.46447401
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.44986028
125MAPK signaling pathway_Homo sapiens_hsa040100.43948944
126Prolactin signaling pathway_Homo sapiens_hsa049170.42420394
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41959981
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41327113
129mTOR signaling pathway_Homo sapiens_hsa041500.40982236
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40121826
131Pathways in cancer_Homo sapiens_hsa052000.40021455
132Non-small cell lung cancer_Homo sapiens_hsa052230.37983014
133Basal transcription factors_Homo sapiens_hsa030220.36609252
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36393331
135Lysosome_Homo sapiens_hsa041420.35225126
136Proteoglycans in cancer_Homo sapiens_hsa052050.31106163

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