STK38L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)6.07966349
2notochord development (GO:0030903)5.50272723
3keratan sulfate catabolic process (GO:0042340)5.28045386
4cartilage development involved in endochondral bone morphogenesis (GO:0060351)5.15703256
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.14069826
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.14069826
7modulation by symbiont of host immune response (GO:0052553)5.14069826
8positive regulation by symbiont of host defense response (GO:0052509)5.14069826
9modulation by symbiont of host defense response (GO:0052031)5.14069826
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.14069826
11regulation of nitric-oxide synthase biosynthetic process (GO:0051769)5.10247839
12detection of molecule of bacterial origin (GO:0032490)5.10190054
13chondrocyte development (GO:0002063)4.96895054
14cell aggregation (GO:0098743)4.95930288
15cartilage condensation (GO:0001502)4.95930288
16negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.95057249
17nucleotide-sugar biosynthetic process (GO:0009226)4.81898210
18negative regulation of striated muscle cell apoptotic process (GO:0010664)4.77956745
19cullin deneddylation (GO:0010388)4.65369917
20cellular extravasation (GO:0045123)4.54682870
21regulation of cardiac muscle cell apoptotic process (GO:0010665)4.40213281
22regulation of B cell receptor signaling pathway (GO:0050855)4.17199722
23negative regulation of dendrite morphogenesis (GO:0050774)4.11160403
24positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.09646304
25regulation of striated muscle cell apoptotic process (GO:0010662)4.05936161
26negative regulation of glycogen biosynthetic process (GO:0045719)4.02540864
27protein deneddylation (GO:0000338)3.99683051
28collagen fibril organization (GO:0030199)3.97556237
29response to peptidoglycan (GO:0032494)3.92811961
30response to muramyl dipeptide (GO:0032495)3.91671722
31regulation of macrophage cytokine production (GO:0010935)3.89463984
32positive regulation of macrophage cytokine production (GO:0060907)3.88678934
33chondroitin sulfate biosynthetic process (GO:0030206)3.80057216
34negative regulation of keratinocyte proliferation (GO:0010839)3.76371525
35heart process (GO:0003015)3.75996626
36heart contraction (GO:0060047)3.75996626
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.71329001
38response to host immune response (GO:0052572)3.71329001
39limb bud formation (GO:0060174)3.70255758
40positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.63442950
41deoxyribose phosphate biosynthetic process (GO:0046385)3.54942235
422-deoxyribonucleotide biosynthetic process (GO:0009265)3.54942235
43response to host (GO:0075136)3.54226501
44response to host defenses (GO:0052200)3.54226501
45response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.54226501
46negative regulation of homotypic cell-cell adhesion (GO:0034111)3.53264238
47positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50973130
48negative regulation of B cell proliferation (GO:0030889)3.49540503
49microglial cell activation (GO:0001774)3.49193005
50positive regulation of endothelial cell differentiation (GO:0045603)3.49182687
51ER overload response (GO:0006983)3.48747435
52regulation of interferon-beta biosynthetic process (GO:0045357)3.46475011
53detection of external biotic stimulus (GO:0098581)3.46314162
54negative regulation of glycogen metabolic process (GO:0070874)3.46124492
55endocardial cushion morphogenesis (GO:0003203)3.44550163
56protein K11-linked deubiquitination (GO:0035871)3.42731186
57macrophage activation involved in immune response (GO:0002281)3.35824353
58myelin assembly (GO:0032288)3.29656267
59detection of biotic stimulus (GO:0009595)3.28055031
60nuclear pore complex assembly (GO:0051292)3.27697861
61relaxation of smooth muscle (GO:0044557)3.27405637
62regulation of transforming growth factor beta2 production (GO:0032909)3.27116856
63regulation of interleukin-6 biosynthetic process (GO:0045408)3.22930953
64negative regulation of interleukin-12 production (GO:0032695)3.22657025
65cardiac muscle tissue morphogenesis (GO:0055008)3.20715660
66neutrophil mediated immunity (GO:0002446)3.20191650
67cartilage development (GO:0051216)3.17233670
68positive regulation of mitochondrial fission (GO:0090141)3.16397546
69detection of other organism (GO:0098543)3.16264179
70limb development (GO:0060173)3.15015897
71appendage development (GO:0048736)3.15015897
72cellular response to ethanol (GO:0071361)3.14437932
73mesenchyme morphogenesis (GO:0072132)3.13209433
74pore complex assembly (GO:0046931)3.12201091
75nuclear pore organization (GO:0006999)3.09781808
76protein neddylation (GO:0045116)3.07256622
77adenosine metabolic process (GO:0046085)3.06871340
78positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.06748630
79regulation of cardiac muscle hypertrophy (GO:0010611)3.04520471
80negative regulation of NF-kappaB import into nucleus (GO:0042347)3.02816337
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.02709530
82positive regulation of osteoblast proliferation (GO:0033690)3.02344820
83T-helper 1 type immune response (GO:0042088)3.00406876
84positive regulation of interferon-alpha production (GO:0032727)2.99881485
85deoxyribonucleotide biosynthetic process (GO:0009263)2.95760834
86mRNA transcription (GO:0009299)2.95564487
87positive regulation of cardiac muscle cell proliferation (GO:0060045)2.95012184
88regulation of muscle hypertrophy (GO:0014743)2.91039308
89protein retention in ER lumen (GO:0006621)2.88825215
90iron ion import (GO:0097286)2.88788955
91negative regulation of smooth muscle cell differentiation (GO:0051151)2.87812684
92positive regulation of gamma-delta T cell activation (GO:0046645)2.87051037
93maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.85778981
94short-term memory (GO:0007614)2.85075887
95ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.83189082
96negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.83121912
97neural crest cell development (GO:0014032)2.81658787
98positive regulation of SMAD protein import into nucleus (GO:0060391)2.80185456
99cranial suture morphogenesis (GO:0060363)2.78270999
100muscle tissue morphogenesis (GO:0060415)2.77772012
101positive regulation of cellular amide metabolic process (GO:0034250)2.77019405
102regulation of glucokinase activity (GO:0033131)2.76900931
103regulation of hexokinase activity (GO:1903299)2.76900931
104histamine secretion (GO:0001821)2.76686005
105B cell receptor signaling pathway (GO:0050853)2.76175066
106chondrocyte differentiation (GO:0002062)2.75636076
107cellular response to BMP stimulus (GO:0071773)2.75241401
108response to BMP (GO:0071772)2.75241401
109T cell migration (GO:0072678)2.74980439
110somite development (GO:0061053)2.74784646
111pathway-restricted SMAD protein phosphorylation (GO:0060389)2.74502696
112regulation of interferon-alpha production (GO:0032647)2.73437962
113interferon-gamma-mediated signaling pathway (GO:0060333)2.73268287
114uterus development (GO:0060065)2.73136551
115positive regulation of cardiac muscle tissue development (GO:0055025)2.73103333
116negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.73000744
117regulation of cardioblast differentiation (GO:0051890)2.71931033
118dermatan sulfate biosynthetic process (GO:0030208)2.70509850
119cyclooxygenase pathway (GO:0019371)2.69801495
120actin-mediated cell contraction (GO:0070252)2.69371155
121production of molecular mediator of immune response (GO:0002440)2.64007650
122cardiac right ventricle morphogenesis (GO:0003215)2.63997346
123prostaglandin biosynthetic process (GO:0001516)2.63621012
124prostanoid biosynthetic process (GO:0046457)2.63621012
125cell proliferation involved in kidney development (GO:0072111)2.63297373
126regulation of MHC class II biosynthetic process (GO:0045346)2.63182621
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.63125244
128cellular glucuronidation (GO:0052695)2.62817150
129B cell homeostasis (GO:0001782)2.61963495
130negative regulation of interleukin-17 production (GO:0032700)2.61922043
131macrophage activation (GO:0042116)2.60841645
132antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60097956
133positive regulation of cardiac muscle tissue growth (GO:0055023)2.60039184
134B cell mediated immunity (GO:0019724)2.59890812
135positive regulation of extracellular matrix organization (GO:1903055)2.59366008
136Rap protein signal transduction (GO:0032486)2.58398194
137regulation of interleukin-8 biosynthetic process (GO:0045414)2.57465486
138regulation of smooth muscle cell differentiation (GO:0051150)2.57230888
139I-kappaB phosphorylation (GO:0007252)2.57020929
140positive regulation of interferon-beta production (GO:0032728)2.56975734
141lung secretory cell differentiation (GO:0061140)2.56795674
142detection of bacterium (GO:0016045)2.56763471
143regulation of vitamin D biosynthetic process (GO:0060556)2.55100883
144regulation of mitotic spindle checkpoint (GO:1903504)2.54471476
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54471476
146regulation of cell maturation (GO:1903429)2.54237350
147lipopolysaccharide-mediated signaling pathway (GO:0031663)2.54150972
148negative regulation of muscle cell apoptotic process (GO:0010656)2.54059005
149embryonic skeletal joint morphogenesis (GO:0060272)2.53476550
150regulation of B cell proliferation (GO:0030888)2.51119464
151actin-myosin filament sliding (GO:0033275)2.51116491
152muscle filament sliding (GO:0030049)2.51116491
153cardiac myofibril assembly (GO:0055003)2.50420278
154intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)2.50071277
155neutrophil activation involved in immune response (GO:0002283)2.49038584
156glucuronate metabolic process (GO:0019585)2.48985202
157uronic acid metabolic process (GO:0006063)2.48985202
158heart valve morphogenesis (GO:0003179)2.48908270
159outflow tract septum morphogenesis (GO:0003148)2.48698300
160poly(A)+ mRNA export from nucleus (GO:0016973)2.48245969
161heart valve formation (GO:0003188)2.48226663
162positive regulation of cytokine biosynthetic process (GO:0042108)2.47681493
163response to gravity (GO:0009629)2.47259664
164ventricular cardiac muscle cell development (GO:0055015)2.46776398
165leukocyte aggregation (GO:0070486)2.46759647
166mRNA transcription from RNA polymerase II promoter (GO:0042789)2.46731699
167pre-miRNA processing (GO:0031054)2.46487257
168histone H3-K36 demethylation (GO:0070544)2.45878353
169positive regulation of interleukin-2 production (GO:0032743)2.45751943
170nucleotide-sugar metabolic process (GO:0009225)2.45479424
171positive regulation of cartilage development (GO:0061036)2.45332134
172cellular response to gamma radiation (GO:0071480)2.45092628
173regulation of interleukin-12 biosynthetic process (GO:0045075)2.41908150
174neutrophil chemotaxis (GO:0030593)2.41281038
175cytokine production involved in immune response (GO:0002367)2.37380433
176regulation of NF-kappaB import into nucleus (GO:0042345)2.37204053
177regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.37154837
178neutrophil migration (GO:1990266)2.34792399
179response to X-ray (GO:0010165)2.34284874
180myeloid leukocyte mediated immunity (GO:0002444)2.33565409
181adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.33330829
182negative regulation of anoikis (GO:2000811)2.31840277
183positive regulation of interleukin-6 production (GO:0032755)2.29745199
184Notch signaling involved in heart development (GO:0061314)2.28004512
185regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.27598418
186defense response to protozoan (GO:0042832)2.27559985
187negative regulation of B cell activation (GO:0050869)2.26829168
188immunoglobulin mediated immune response (GO:0016064)2.26658745
189regulation of histone H3-K9 methylation (GO:0051570)2.26054019
190positive regulation of interleukin-10 production (GO:0032733)2.25473108
191ribosome assembly (GO:0042255)2.25156222
192regulation of B cell differentiation (GO:0045577)2.24593091
193histamine transport (GO:0051608)2.24015856
194response to protozoan (GO:0001562)2.23902486
195positive regulation of toll-like receptor signaling pathway (GO:0034123)2.22328004
196regulation of oxidative stress-induced neuron death (GO:1903203)2.20571356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.89804852
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.54401939
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.16308590
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.87976982
5* SMAD_19615063_ChIP-ChIP_OVARY_Human2.69010583
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.68276718
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.59646355
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.56586426
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.37248903
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25504475
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.18064360
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.17963135
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17087606
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.15928971
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.11624595
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10543543
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10024967
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.09559251
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.01016533
20GBX2_23144817_ChIP-Seq_PC3_Human1.98534938
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97480156
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.96855281
23IRF8_27001747_Chip-Seq_BMDM_Mouse1.96666149
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.93057330
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93040690
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92688444
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.91886888
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91617586
29CJUN_26792858_Chip-Seq_BT549_Human1.91232655
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88816150
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88262956
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.88075182
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.86475600
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.82367107
35GATA1_22025678_ChIP-Seq_K562_Human1.78843396
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.77506895
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76913552
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.74233325
39* P300_19829295_ChIP-Seq_ESCs_Human1.72554313
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71961862
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71961862
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71961862
43STAT3_18555785_Chip-Seq_ESCs_Mouse1.71740585
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.71098449
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.70943345
46WT1_19549856_ChIP-ChIP_CCG9911_Human1.68279864
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.66826416
48E2F1_18555785_Chip-Seq_ESCs_Mouse1.65328827
49P53_22387025_ChIP-Seq_ESCs_Mouse1.64373065
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.63643837
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61344561
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58861901
53PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56766073
54* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55100916
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.54713626
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.53333064
57SMAD4_21799915_ChIP-Seq_A2780_Human1.51606011
58SOX2_18555785_Chip-Seq_ESCs_Mouse1.51324420
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51169091
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.47385405
61NMYC_18555785_Chip-Seq_ESCs_Mouse1.45285623
62TP53_18474530_ChIP-ChIP_U2OS_Human1.45262703
63VDR_24787735_ChIP-Seq_THP-1_Human1.42436745
64PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40784948
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40285411
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40285411
67AR_21572438_ChIP-Seq_LNCaP_Human1.39239057
68* SPI1_23547873_ChIP-Seq_NB4_Human1.38423831
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.36702898
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.36606514
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35405680
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35163407
73* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.33055907
74MYB_26560356_Chip-Seq_TH2_Human1.32958733
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32782916
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31304250
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31189804
78SALL4_22934838_ChIP-ChIP_CD34+_Human1.31019400
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31009918
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30782580
81* NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30492164
82BRD4_25478319_ChIP-Seq_HGPS_Human1.30025662
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.29348348
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29334923
85ZFX_18555785_Chip-Seq_ESCs_Mouse1.29147096
86* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28968005
87PU_27001747_Chip-Seq_BMDM_Mouse1.28958154
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28489994
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.27409673
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.27409673
91EWS_26573619_Chip-Seq_HEK293_Human1.26296881
92FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.26258371
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26034452
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25748273
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25444977
96RUNX_20019798_ChIP-Seq_JUKART_Human1.25095019
97ELK1_19687146_ChIP-ChIP_HELA_Human1.25001462
98VDR_22108803_ChIP-Seq_LS180_Human1.24891717
99P300_18555785_Chip-Seq_ESCs_Mouse1.24676558
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24620506
101OCT4_18555785_Chip-Seq_ESCs_Mouse1.24482720
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24002907
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23466406
104NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22573301
105RUNX1_27457419_Chip-Seq_LIVER_Mouse1.21943612
106FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20684412
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.19944244
108FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.19757482
109PU1_27457419_Chip-Seq_LIVER_Mouse1.18581764
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17935773
111ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17743630
112* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17177865
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17176625
114TAF15_26573619_Chip-Seq_HEK293_Human1.16839227
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.16685265
116SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16404932
117* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14982019
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14485183
119SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14375755
120CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13928833
121* STAT3_23295773_ChIP-Seq_U87_Human1.13549878
122ER_23166858_ChIP-Seq_MCF-7_Human1.13220927
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12868019
124* TCF4_22108803_ChIP-Seq_LS180_Human1.10395226
125CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09973210
126TP63_23658742_ChIP-Seq_EP156T_Human1.09829422
127* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09161735
128TP53_16413492_ChIP-PET_HCT116_Human1.08271120
129* CDX2_22108803_ChIP-Seq_LS180_Human1.07782999
130CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07619117
131* SMAD3_21741376_ChIP-Seq_EPCs_Human1.07487027
132NANOG_19829295_ChIP-Seq_ESCs_Human1.07001071
133SOX2_19829295_ChIP-Seq_ESCs_Human1.07001071
134SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06601120
135PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06474395
136CTCF_18555785_Chip-Seq_ESCs_Mouse1.06229164
137GF1B_26923725_Chip-Seq_HPCs_Mouse1.06177568
138BCAT_22108803_ChIP-Seq_LS180_Human1.06132529
139POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05816287
140E2F4_17652178_ChIP-ChIP_JURKAT_Human1.05483177
141* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05134966
142FUS_26573619_Chip-Seq_HEK293_Human1.04192769
143ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04156281
144OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03048199
145MYB_26560356_Chip-Seq_TH1_Human1.01501484
146HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97093857
147ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96360265
148IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.96142672
149SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91105144
150* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90962933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.14234599
2MP0009697_abnormal_copulation3.83017761
3MP0003646_muscle_fatigue3.69000066
4MP0000566_synostosis3.56094290
5MP0003123_paternal_imprinting3.55448470
6MP0003787_abnormal_imprinting3.41288308
7MP0002006_tumorigenesis3.08154595
8MP0002933_joint_inflammation3.04495007
9MP0002166_altered_tumor_susceptibility2.95679430
10MP0008438_abnormal_cutaneous_collagen2.90908149
11MP0002163_abnormal_gland_morphology2.83057703
12MP0004134_abnormal_chest_morphology2.81972939
13MP0009250_abnormal_appendicular_skeleto2.80547002
14MP0003300_gastrointestinal_ulcer2.78915941
15MP0003724_increased_susceptibility_to2.54411894
16MP0003121_genomic_imprinting2.54252519
17MP0010352_gastrointestinal_tract_polyps2.49202413
18MP0002282_abnormal_trachea_morphology2.44220096
19MP0002009_preneoplasia2.37548263
20MP0003941_abnormal_skin_development2.36349201
21MP0000163_abnormal_cartilage_morphology2.28860959
22MP0005171_absent_coat_pigmentation2.24156688
23MP0000685_abnormal_immune_system2.20271514
24MP0003122_maternal_imprinting2.18579161
25MP0001835_abnormal_antigen_presentation2.08524851
26MP0003828_pulmonary_edema2.07353281
27MP0005508_abnormal_skeleton_morphology2.06003692
28MP0006054_spinal_hemorrhage2.05392076
29MP0003303_peritoneal_inflammation2.05184281
30MP0001542_abnormal_bone_strength2.04356169
31MP0000749_muscle_degeneration2.03223925
32MP0002115_abnormal_skeleton_extremities1.98925098
33MP0010234_abnormal_vibrissa_follicle1.94409327
34MP0001800_abnormal_humoral_immune1.90998371
35MP0008877_abnormal_DNA_methylation1.85574671
36MP0005623_abnormal_meninges_morphology1.83315070
37MP0005275_abnormal_skin_tensile1.83004104
38MP0004084_abnormal_cardiac_muscle1.78982617
39MP0003806_abnormal_nucleotide_metabolis1.78971368
40MP0000569_abnormal_digit_pigmentation1.78734582
41MP0002452_abnormal_antigen_presenting1.74039862
42MP0001177_atelectasis1.72471591
43MP0003221_abnormal_cardiomyocyte_apopto1.69778350
44MP0002419_abnormal_innate_immunity1.66386184
45MP0005000_abnormal_immune_tolerance1.66080901
46MP0009785_altered_susceptibility_to1.65465934
47MP0001790_abnormal_immune_system1.64250394
48MP0005387_immune_system_phenotype1.64250394
49MP0008007_abnormal_cellular_replicative1.63108265
50MP0005671_abnormal_response_to1.62851515
51MP0002113_abnormal_skeleton_development1.62522263
52MP0002972_abnormal_cardiac_muscle1.60510347
53MP0003705_abnormal_hypodermis_morpholog1.59488029
54MP0002254_reproductive_system_inflammat1.58465591
55MP0005367_renal/urinary_system_phenotyp1.55299370
56MP0000516_abnormal_urinary_system1.55299370
57MP0010030_abnormal_orbit_morphology1.51038342
58MP0008260_abnormal_autophagy1.48354812
59MP0002109_abnormal_limb_morphology1.48094566
60MP0003755_abnormal_palate_morphology1.45702594
61MP0003091_abnormal_cell_migration1.44929790
62MP0002723_abnormal_immune_serum1.43369717
63MP0003566_abnormal_cell_adhesion1.42682017
64MP0005390_skeleton_phenotype1.41341787
65MP0009780_abnormal_chondrocyte_physiolo1.41249023
66MP0003436_decreased_susceptibility_to1.40695513
67MP0010678_abnormal_skin_adnexa1.37510686
68MP0002148_abnormal_hypersensitivity_rea1.36918443
69MP0009764_decreased_sensitivity_to1.36662463
70MP0000762_abnormal_tongue_morphology1.35511629
71MP0000767_abnormal_smooth_muscle1.35182422
72MP0006138_congestive_heart_failure1.33662055
73MP0002420_abnormal_adaptive_immunity1.33386846
74MP0009384_cardiac_valve_regurgitation1.32343411
75MP0003252_abnormal_bile_duct1.32236838
76MP0001819_abnormal_immune_cell1.31613722
77MP0002938_white_spotting1.31395683
78MP0005379_endocrine/exocrine_gland_phen1.30707028
79MP0004947_skin_inflammation1.30645641
80MP0003448_altered_tumor_morphology1.30299505
81MP0002877_abnormal_melanocyte_morpholog1.29396816
82MP0000049_abnormal_middle_ear1.28769395
83MP0002138_abnormal_hepatobiliary_system1.27221341
84MP0003385_abnormal_body_wall1.25303566
85MP0002108_abnormal_muscle_morphology1.24019591
86MP0008775_abnormal_heart_ventricle1.20553730
87MP0000432_abnormal_head_morphology1.16241068
88MP0003279_aneurysm1.16041695
89MP0002928_abnormal_bile_duct1.14327697
90MP0002876_abnormal_thyroid_physiology1.13505384
91MP0002398_abnormal_bone_marrow1.11812369
92MP0005646_abnormal_pituitary_gland1.11431515
93MP0004036_abnormal_muscle_relaxation1.10632589
94MP0005620_abnormal_muscle_contractility1.10171233
95MP0004957_abnormal_blastocyst_morpholog1.09174583
96MP0005408_hypopigmentation1.08771925
97MP0001984_abnormal_olfaction1.08197902
98MP0005166_decreased_susceptibility_to1.07175916
99MP0002233_abnormal_nose_morphology1.07009012
100MP0002116_abnormal_craniofacial_bone1.06754672
101MP0004484_altered_response_of1.06746706
102MP0008057_abnormal_DNA_replication1.05439459
103MP0003937_abnormal_limbs/digits/tail_de1.04264791
104MP0000716_abnormal_immune_system1.04204448
105MP0000383_abnormal_hair_follicle1.03922487
106MP0004782_abnormal_surfactant_physiolog1.02864118
107MP0003195_calcinosis1.00907975
108MP0000858_altered_metastatic_potential1.00340191
109MP0000372_irregular_coat_pigmentation1.00079044
110MP0005025_abnormal_response_to0.99921978
111MP0003453_abnormal_keratinocyte_physiol0.99728398
112MP0001270_distended_abdomen0.99704454
113MP0000343_altered_response_to0.99403358
114MP0001845_abnormal_inflammatory_respons0.97290769
115MP0004215_abnormal_myocardial_fiber0.96878910
116MP0002405_respiratory_system_inflammati0.96607207
117MP0010155_abnormal_intestine_physiology0.96339366
118MP0002088_abnormal_embryonic_growth/wei0.96278727
119MP0001119_abnormal_female_reproductive0.96183843
120MP0001188_hyperpigmentation0.96102130
121MP0003984_embryonic_growth_retardation0.95404982
122MP0008789_abnormal_olfactory_epithelium0.94890828
123MP0002837_dystrophic_cardiac_calcinosis0.94069335
124MP0002896_abnormal_bone_mineralization0.93945435
125MP0003935_abnormal_craniofacial_develop0.93846918
126MP0003786_premature_aging0.93293905
127MP0003795_abnormal_bone_structure0.93190758
128MP0003950_abnormal_plasma_membrane0.92434083
129MP0003718_maternal_effect0.91950624
130MP0002060_abnormal_skin_morphology0.91598215
131MP0005167_abnormal_blood-brain_barrier0.91471074
132MP0002998_abnormal_bone_remodeling0.91105276
133MP0000350_abnormal_cell_proliferation0.88946130
134MP0006292_abnormal_olfactory_placode0.86709711
135MP0003763_abnormal_thymus_physiology0.86696878
136MP0003656_abnormal_erythrocyte_physiolo0.86625753
137MP0001919_abnormal_reproductive_system0.85842504
138MP0002111_abnormal_tail_morphology0.85811044
139MP0003942_abnormal_urinary_system0.85772527
140MP0004808_abnormal_hematopoietic_stem0.84844118
141MP0003077_abnormal_cell_cycle0.84256491
142MP0005248_abnormal_Harderian_gland0.83794596
143MP0003186_abnormal_redox_activity0.83522994
144MP0002133_abnormal_respiratory_system0.83415244
145MP0005388_respiratory_system_phenotype0.83415244
146MP0001853_heart_inflammation0.82717863
147MP0002127_abnormal_cardiovascular_syste0.82670495
148MP0001544_abnormal_cardiovascular_syste0.82584823
149MP0005385_cardiovascular_system_phenoty0.82584823
150MP0002396_abnormal_hematopoietic_system0.82422811
151MP0005084_abnormal_gallbladder_morpholo0.82105923
152MP0002429_abnormal_blood_cell0.81845055
153MP0009703_decreased_birth_body0.81376307
154MP0000751_myopathy0.81011059
155MP0005451_abnormal_body_composition0.80478973
156MP0010630_abnormal_cardiac_muscle0.80142511
157MP0001851_eye_inflammation0.79806910
158MP0009053_abnormal_anal_canal0.78823791
159MP0004272_abnormal_basement_membrane0.78682144
160MP0001299_abnormal_eye_distance/0.78149517
161MP0008058_abnormal_DNA_repair0.78107231
162MP0010368_abnormal_lymphatic_system0.77886788
163MP0005464_abnormal_platelet_physiology0.77039166
164MP0003045_fibrosis0.76745817
165MP0005389_reproductive_system_phenotype0.76530002
166MP0000689_abnormal_spleen_morphology0.76447337
167MP0001533_abnormal_skeleton_physiology0.75527828
168MP0002722_abnormal_immune_system0.75348264
169MP0002735_abnormal_chemical_nociception0.74302127
170MP0001915_intracranial_hemorrhage0.73912775
171MP0005380_embryogenesis_phenotype0.73283197
172MP0001672_abnormal_embryogenesis/_devel0.73283197
173MP0004264_abnormal_extraembryonic_tissu0.71958215
174MP0002114_abnormal_axial_skeleton0.71344084
175MP0010307_abnormal_tumor_latency0.70863496
176MP0010386_abnormal_urinary_bladder0.70492381
177MP0002168_other_aberrant_phenotype0.70220115
178MP0000465_gastrointestinal_hemorrhage0.70209585
179MP0000249_abnormal_blood_vessel0.70190942
180MP0002249_abnormal_larynx_morphology0.67662448
181MP0002160_abnormal_reproductive_system0.66997243

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)7.95474749
2Irregular epiphyses (HP:0010582)7.91884236
3Vitreoretinal degeneration (HP:0000655)6.23875072
4Small epiphyses (HP:0010585)5.95200021
5Flat capital femoral epiphysis (HP:0003370)5.06402064
6Metaphyseal dysplasia (HP:0100255)4.96569529
7Abnormal tarsal ossification (HP:0008369)4.77264337
8Delayed epiphyseal ossification (HP:0002663)4.69255085
9Metaphyseal cupping (HP:0003021)4.68254326
10Genu varum (HP:0002970)4.64151000
11Cupped ribs (HP:0000887)4.55728023
12Hypoplastic ischia (HP:0003175)4.48668487
13Mild short stature (HP:0003502)4.33816701
14Abnormality of the ischium (HP:0003174)4.33434403
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.22117810
16Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.20822734
17Abnormality of femoral epiphyses (HP:0006499)4.20822734
18Abnormality of the vertebral endplates (HP:0005106)4.15050025
19Irregular vertebral endplates (HP:0003301)4.06681105
20Abnormality of the epiphysis of the femoral head (HP:0010574)3.98192725
21Papillary thyroid carcinoma (HP:0002895)3.89368431
22Abnormality of the femoral head (HP:0003368)3.87869367
23Abnormality of incisor morphology (HP:0011063)3.70300256
24Abnormal foot bone ossification (HP:0010675)3.67889470
25Aortic dissection (HP:0002647)3.66536500
26Absent epiphyses (HP:0010577)3.51797802
27Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.51797802
28Chronic mucocutaneous candidiasis (HP:0002728)3.49405744
29Recurrent cutaneous fungal infections (HP:0011370)3.49405744
30Arthropathy (HP:0003040)3.44748610
31Flattened epiphyses (HP:0003071)3.40804867
32Spondylolisthesis (HP:0003302)3.40406805
33Neonatal short-limb short stature (HP:0008921)3.37837684
34Short femoral neck (HP:0100864)3.37085753
35Flat acetabular roof (HP:0003180)3.34937598
36Carpal bone hypoplasia (HP:0001498)3.26138331
37Patent foramen ovale (HP:0001655)3.16266746
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.15807954
39Metaphyseal irregularity (HP:0003025)3.14922769
40Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.07218221
41IgM deficiency (HP:0002850)2.98982643
42Stenosis of the external auditory canal (HP:0000402)2.98306596
43Osteoarthritis (HP:0002758)2.97462394
44Hepatoblastoma (HP:0002884)2.95060989
45Abnormality of the proximal phalanges of the hand (HP:0009834)2.91960801
46Premature rupture of membranes (HP:0001788)2.81207601
47Retrobulbar optic neuritis (HP:0100654)2.80366599
48Optic neuritis (HP:0100653)2.80366599
49Spastic diplegia (HP:0001264)2.79668767
50Coxa vara (HP:0002812)2.75014753
51IgA deficiency (HP:0002720)2.74817419
52Thyroid carcinoma (HP:0002890)2.74314103
53Recurrent bacterial skin infections (HP:0005406)2.73316407
54Adrenal hypoplasia (HP:0000835)2.70845525
55Enlarged epiphyses (HP:0010580)2.68610859
56Arterial tortuosity (HP:0005116)2.65824768
57Amaurosis fugax (HP:0100576)2.65331983
58Abnormality of carpal bone ossification (HP:0006257)2.61601975
59Viral hepatitis (HP:0006562)2.60606822
60Pulmonary artery stenosis (HP:0004415)2.60018328
61Pulmonary infiltrates (HP:0002113)2.59931504
62Stillbirth (HP:0003826)2.57768774
63Beaking of vertebral bodies (HP:0004568)2.57480359
64Recurrent skin infections (HP:0001581)2.55159903
65Peritonitis (HP:0002586)2.54865578
66Mesomelia (HP:0003027)2.52614613
67Platyspondyly (HP:0000926)2.50254593
68Abnormal vertebral ossification (HP:0100569)2.49738423
69Recurrent viral infections (HP:0004429)2.49401819
70Mediastinal lymphadenopathy (HP:0100721)2.49328598
71Xerostomia (HP:0000217)2.48168660
72Abnormality of the left ventricular outflow tract (HP:0011103)2.46366290
73Subaortic stenosis (HP:0001682)2.46366290
74Abnormality of the pubic bones (HP:0003172)2.45902817
75Barrel-shaped chest (HP:0001552)2.44692569
76Arterial thrombosis (HP:0004420)2.44278489
77Right ventricular cardiomyopathy (HP:0011663)2.40145538
78Tetraparesis (HP:0002273)2.39522891
79Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.38177980
80Neonatal hypoglycemia (HP:0001998)2.37876087
81Spinal cord lesions (HP:0100561)2.36683787
82Syringomyelia (HP:0003396)2.36683787
83Hematochezia (HP:0002573)2.35802181
84Orchitis (HP:0100796)2.34571205
85Fatigue (HP:0012378)2.34515758
86Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34225333
87Vertebral arch anomaly (HP:0008438)2.33203487
88Limited hip movement (HP:0008800)2.32819616
89Vasculitis (HP:0002633)2.32766529
90Facial diplegia (HP:0001349)2.29258486
91Aplasia/hypoplasia of the femur (HP:0005613)2.28523618
92Fibular hypoplasia (HP:0003038)2.27063089
93Abnormality of the phalanges of the 2nd finger (HP:0009541)2.27060875
94Meningitis (HP:0001287)2.26721092
95Neoplasm of the adrenal cortex (HP:0100641)2.25877798
96Abnormality of T cell physiology (HP:0011840)2.24480943
97Chest pain (HP:0100749)2.23519574
98Bicuspid aortic valve (HP:0001647)2.23131755
99Curly hair (HP:0002212)2.23102909
100Autoimmune hemolytic anemia (HP:0001890)2.22958971
101Abnormality of the phalanges of the 5th finger (HP:0004213)2.22826052
102Long clavicles (HP:0000890)2.18727475
103Aortic aneurysm (HP:0004942)2.18233801
104Osteolytic defects of the hand bones (HP:0009699)2.17238605
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.17238605
106Micromelia (HP:0002983)2.14426277
107Long nose (HP:0003189)2.14297223
108Hemoptysis (HP:0002105)2.14180445
109Waddling gait (HP:0002515)2.13569761
110Thin ribs (HP:0000883)2.13076372
111Recurrent abscess formation (HP:0002722)2.12730772
112Eczematoid dermatitis (HP:0000976)2.11402881
113Broad phalanx (HP:0006009)2.11322681
114Recurrent fungal infections (HP:0002841)2.09173563
115Spinal cord compression (HP:0002176)2.08945317
116Neoplasm of the tracheobronchial system (HP:0100552)2.08902882
117Ovoid vertebral bodies (HP:0003300)2.08136672
118Hypoplasia of the odontoid process (HP:0003311)2.07690614
119Keratoconjunctivitis sicca (HP:0001097)2.07304736
120Dilatation of the ascending aorta (HP:0005111)2.04803433
121Gastrointestinal infarctions (HP:0005244)2.04691400
122Absent frontal sinuses (HP:0002688)2.04489234
123Transitional cell carcinoma of the bladder (HP:0006740)2.04282840
124Vascular tortuosity (HP:0004948)2.03988259
125Recurrent lower respiratory tract infections (HP:0002783)2.03082825
126Protuberant abdomen (HP:0001538)2.00765104
127Broad long bones (HP:0005622)1.99427028
128Cervical subluxation (HP:0003308)1.98272248
129Agammaglobulinemia (HP:0004432)1.98049711
130Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.96243575
131Rhabdomyosarcoma (HP:0002859)1.95908690
132Premature loss of primary teeth (HP:0006323)1.95456990
133Abnormality of the peritoneum (HP:0002585)1.95332161
134Disproportionate short-trunk short stature (HP:0003521)1.94463434
135Mitral valve prolapse (HP:0001634)1.94310147
136Abnormality of T cell number (HP:0011839)1.93366298
137Abnormality of primary teeth (HP:0006481)1.93211426
138Abnormal pancreas size (HP:0012094)1.93061178
139Abnormal hand bone ossification (HP:0010660)1.92829316
140Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.90407034
141Bladder carcinoma (HP:0002862)1.88651470
142Bladder neoplasm (HP:0009725)1.88651470
143Colitis (HP:0002583)1.88481209
144Short middle phalanx of finger (HP:0005819)1.87492407
145Deep philtrum (HP:0002002)1.86262368
146Lymphopenia (HP:0001888)1.86167374
147Diastasis recti (HP:0001540)1.85854463
148Abnormality of cells of the lymphoid lineage (HP:0012140)1.85603890
149Hip dysplasia (HP:0001385)1.85443754
150Myocardial infarction (HP:0001658)1.85441127
151Limited elbow extension (HP:0001377)1.84914716
152Large earlobe (HP:0009748)1.84711895
153Abnormality of the distal phalanx of the thumb (HP:0009617)1.84243814
154Abnormal platelet volume (HP:0011876)1.83843374
155Distal lower limb muscle weakness (HP:0009053)1.83817818
156Alveolar cell carcinoma (HP:0006519)1.83494993
157Hypoplastic ilia (HP:0000946)1.83074278
158Pulmonic stenosis (HP:0001642)1.82730583
159Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82634496
160Hip contracture (HP:0003273)1.82516572
161Spontaneous hematomas (HP:0007420)1.82174907
162Abnormal biliary tract morphology (HP:0012440)1.81764408
163Acute myeloid leukemia (HP:0004808)1.81572747
164Pelvic girdle muscle weakness (HP:0003749)1.81291864
165Stomatitis (HP:0010280)1.81213323
166Recurrent pneumonia (HP:0006532)1.80185370
167Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.78769948
168Vertebral hypoplasia (HP:0008417)1.78769948
169Abnormality of macrophages (HP:0004311)1.78429174
170Panhypogammaglobulinemia (HP:0003139)1.78215921
171Keratoconjunctivitis (HP:0001096)1.77609795
172Relative macrocephaly (HP:0004482)1.76873784
173Abnormal ossification of hand bones (HP:0005921)1.76794691
174Abnormality of the musculature of the pelvis (HP:0001469)1.76745744
175Abnormality of the hip-girdle musculature (HP:0001445)1.76745744
176T lymphocytopenia (HP:0005403)1.76082456
177Abnormality of the prostate (HP:0008775)1.75137795
178Exocrine pancreatic insufficiency (HP:0001738)1.75050337
179Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74968548
180Hypothermia (HP:0002045)1.72138373
181Cystic hygroma (HP:0000476)1.71815811
182Thoracolumbar scoliosis (HP:0002944)1.68906102
183Subacute progressive viral hepatitis (HP:0006572)1.67435296
184Glossoptosis (HP:0000162)1.66783147
185Neoplasm of the adrenal gland (HP:0100631)1.66704524
186Broad phalanges of the hand (HP:0009768)1.66456653
187Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.64313942
188Overgrowth (HP:0001548)1.63327860
189Broad finger (HP:0001500)1.62475467
190Exostoses (HP:0100777)1.62291565
191Aplasia/Hypoplasia of the fibula (HP:0006492)1.61347528
192Abnormal hair whorl (HP:0010721)1.60481343
193Carpal synostosis (HP:0009702)1.60368032

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.70402841
2AKT33.41438911
3ZAK3.01753026
4PLK22.78011566
5TAF12.75955087
6MAP3K32.68703903
7BMPR22.62545341
8ERBB32.54274099
9TNIK2.53084913
10OBSCN2.44503816
11BLK2.24695398
12* STK242.22439350
13SGK22.19622853
14MAP3K142.08384562
15PLK42.06829120
16NUAK11.95860471
17MKNK21.95821670
18BRD41.90451438
19MYLK1.88738254
20PLK31.80810658
21DMPK1.80204687
22DDR21.80191694
23SIK31.78319488
24BCR1.77322949
25FRK1.76571770
26CDK61.75139143
27IRAK31.74934112
28BRSK21.72138602
29PRPF4B1.70548271
30IRAK41.66947784
31NEK61.65043682
32INSRR1.62567838
33FGR1.60594611
34TEC1.55264000
35CSK1.54940829
36TRPM71.54014233
37NME11.51662475
38MKNK11.48109415
39RIPK41.47082439
40ACVR1B1.42087589
41SGK31.38591277
42SGK2231.37940369
43SGK4941.37940369
44SRPK11.35669653
45JAK11.34344368
46* STK31.33936400
47PIK3CA1.32240815
48EIF2AK31.31002561
49PAK31.30970974
50IKBKE1.30622184
51IRAK11.30489143
52YES11.27957261
53EIF2AK21.26450929
54NLK1.24839167
55MARK31.24346556
56PRKG21.24103836
57EIF2AK11.24016689
58MAP3K101.21403570
59TGFBR11.20698975
60IRAK21.19342409
61LATS11.11688710
62MATK1.10842302
63BRSK11.09719440
64MAP3K121.07525700
65MAP2K71.06636325
66EPHA21.06548661
67JAK31.06396295
68MST41.03862405
69PASK1.03138819
70PDK21.02421199
71NEK90.95306210
72PIK3CG0.94217601
73BMPR1B0.91884983
74PIM10.90639986
75BRAF0.89564576
76ERBB40.89126178
77PINK10.87810329
78TYK20.87057564
79MAP3K130.86847394
80CHUK0.85239225
81MAP3K60.83120443
82ITK0.82820217
83PIM20.82525978
84RPS6KB10.81853361
85TTN0.81032811
86KIT0.80526406
87SYK0.77383269
88FGFR20.76734814
89KSR10.75989147
90HCK0.75577239
91CDK90.71981579
92* STK38L0.71859686
93ROCK10.71480055
94IKBKB0.71241040
95PRKCE0.70269065
96PDK30.68639043
97PDK40.68639043
98MST1R0.68464324
99LIMK10.67146777
100ALK0.66129011
101LYN0.66071817
102PBK0.62700231
103OXSR10.62129329
104JAK20.61826789
105LATS20.61683017
106FGFR10.60173971
107FGFR30.59492119
108MELK0.59245152
109RPS6KA40.58015892
110EGFR0.57925026
111CDC42BPA0.57649664
112DYRK1A0.57354864
113CSF1R0.57201187
114TSSK60.57008143
115ROCK20.55254970
116TGFBR20.54762643
117PAK20.54017737
118TBK10.52944463
119ADRBK20.52000317
120CDK80.50885774
121MAP2K30.49926215
122BTK0.49798444
123FER0.49293750
124PAK40.49197327
125PRKCH0.47981541
126RAF10.47931724
127PDGFRB0.47856905
128MAP4K10.47110803
129PLK10.46666906
130SGK10.44106557
131DYRK30.43499836
132LMTK20.42640023
133TTK0.40918336
134PRKCI0.40814916
135MAP3K20.40730454
136CCNB10.40672227
137CDK120.40412251
138MAP2K10.40086771
139STK40.39142679
140ATM0.38079882
141MAPK70.36372793
142GRK70.35828904
143PRKG10.34147164
144MET0.33932437
145PRKAA10.33199826
146CSNK2A10.32956633
147MAP3K50.32656357
148TIE10.32483502
149MUSK0.32473809
150MAPK30.31631349
151TESK10.30968534
152PRKCG0.30737692
153BUB10.28676180
154CDK30.27499571
155MAPK100.27084435
156WNK10.26648656
157MAP3K40.26494301
158MAPK130.25569998
159ARAF0.25271453

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.27629454
2Leishmaniasis_Homo sapiens_hsa051403.04185772
3Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005203.02219898
4ECM-receptor interaction_Homo sapiens_hsa045123.01019751
5Basal transcription factors_Homo sapiens_hsa030222.77065106
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.63368469
7Proteasome_Homo sapiens_hsa030502.35001961
8Protein export_Homo sapiens_hsa030602.34303103
9Asthma_Homo sapiens_hsa053102.31092871
10Steroid biosynthesis_Homo sapiens_hsa001002.27878597
11Protein digestion and absorption_Homo sapiens_hsa049742.27142701
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.22339453
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.20820543
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20724831
15Sulfur metabolism_Homo sapiens_hsa009202.17060671
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.15115585
17Viral myocarditis_Homo sapiens_hsa054162.06547958
18RNA polymerase_Homo sapiens_hsa030201.92253779
19Measles_Homo sapiens_hsa051621.86987622
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.85684565
21TGF-beta signaling pathway_Homo sapiens_hsa043501.84984725
22One carbon pool by folate_Homo sapiens_hsa006701.82923092
23Tuberculosis_Homo sapiens_hsa051521.81184327
24Herpes simplex infection_Homo sapiens_hsa051681.79826755
25Staphylococcus aureus infection_Homo sapiens_hsa051501.77072728
26Olfactory transduction_Homo sapiens_hsa047401.73790772
27B cell receptor signaling pathway_Homo sapiens_hsa046621.73250645
28Toxoplasmosis_Homo sapiens_hsa051451.72970426
29Arachidonic acid metabolism_Homo sapiens_hsa005901.66351375
30Osteoclast differentiation_Homo sapiens_hsa043801.64111771
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61551340
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.59865603
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.58360561
34Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.55314731
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.53309172
36Starch and sucrose metabolism_Homo sapiens_hsa005001.52698970
37Selenocompound metabolism_Homo sapiens_hsa004501.52657217
38TNF signaling pathway_Homo sapiens_hsa046681.48038246
39Galactose metabolism_Homo sapiens_hsa000521.47058414
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45703040
41Antigen processing and presentation_Homo sapiens_hsa046121.41386472
42Malaria_Homo sapiens_hsa051441.37771695
43Shigellosis_Homo sapiens_hsa051311.37396912
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26403336
45Legionellosis_Homo sapiens_hsa051341.24731122
46Hematopoietic cell lineage_Homo sapiens_hsa046401.22480135
47Dilated cardiomyopathy_Homo sapiens_hsa054141.21468610
48Homologous recombination_Homo sapiens_hsa034401.19998106
49Leukocyte transendothelial migration_Homo sapiens_hsa046701.17773538
50Huntingtons disease_Homo sapiens_hsa050161.16273417
51Cell cycle_Homo sapiens_hsa041101.13721375
52Thyroid cancer_Homo sapiens_hsa052161.12361479
53Small cell lung cancer_Homo sapiens_hsa052221.11242101
54Hepatitis B_Homo sapiens_hsa051611.10525942
55Purine metabolism_Homo sapiens_hsa002301.10448908
56Hippo signaling pathway_Homo sapiens_hsa043901.10431513
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09763551
58Focal adhesion_Homo sapiens_hsa045101.08940274
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08656801
60Sphingolipid metabolism_Homo sapiens_hsa006001.06581601
61Oxidative phosphorylation_Homo sapiens_hsa001901.05619286
62Salmonella infection_Homo sapiens_hsa051321.03885071
63PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00025703
64Amoebiasis_Homo sapiens_hsa051460.98336604
65Non-homologous end-joining_Homo sapiens_hsa034500.97373700
66Rheumatoid arthritis_Homo sapiens_hsa053230.97371517
67Hepatitis C_Homo sapiens_hsa051600.96521676
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96044617
69Fructose and mannose metabolism_Homo sapiens_hsa000510.95937738
70Phagosome_Homo sapiens_hsa041450.92918846
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.92153378
72Chemokine signaling pathway_Homo sapiens_hsa040620.92138082
73Proteoglycans in cancer_Homo sapiens_hsa052050.91871061
74Cardiac muscle contraction_Homo sapiens_hsa042600.91807737
75Parkinsons disease_Homo sapiens_hsa050120.90951378
76Dorso-ventral axis formation_Homo sapiens_hsa043200.89417302
77Platelet activation_Homo sapiens_hsa046110.88306191
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88158770
79Colorectal cancer_Homo sapiens_hsa052100.87023595
80Pancreatic cancer_Homo sapiens_hsa052120.86447288
81Renal cell carcinoma_Homo sapiens_hsa052110.85610202
82Hedgehog signaling pathway_Homo sapiens_hsa043400.85554343
83Type I diabetes mellitus_Homo sapiens_hsa049400.84686040
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84584337
85T cell receptor signaling pathway_Homo sapiens_hsa046600.83697809
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82371646
87Pertussis_Homo sapiens_hsa051330.81202493
88MicroRNAs in cancer_Homo sapiens_hsa052060.80334561
89Primary immunodeficiency_Homo sapiens_hsa053400.79861783
90Fatty acid elongation_Homo sapiens_hsa000620.79182093
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79085936
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78874370
93Pyrimidine metabolism_Homo sapiens_hsa002400.78785314
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.77942541
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77239234
96Chronic myeloid leukemia_Homo sapiens_hsa052200.77107302
97Apoptosis_Homo sapiens_hsa042100.76746381
98Viral carcinogenesis_Homo sapiens_hsa052030.76241321
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73991309
100Systemic lupus erythematosus_Homo sapiens_hsa053220.71434837
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70851429
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68719794
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68599615
104Folate biosynthesis_Homo sapiens_hsa007900.68579423
105Vibrio cholerae infection_Homo sapiens_hsa051100.68506979
106Mineral absorption_Homo sapiens_hsa049780.68323874
107Basal cell carcinoma_Homo sapiens_hsa052170.68216344
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66926392
109Adherens junction_Homo sapiens_hsa045200.64500548
110Epstein-Barr virus infection_Homo sapiens_hsa051690.63480995
111RNA transport_Homo sapiens_hsa030130.62486794
112Ovarian steroidogenesis_Homo sapiens_hsa049130.61943564
113Prostate cancer_Homo sapiens_hsa052150.60881466
114Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60542580
115Propanoate metabolism_Homo sapiens_hsa006400.59484361
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58491806
117HTLV-I infection_Homo sapiens_hsa051660.57723578
118Phenylalanine metabolism_Homo sapiens_hsa003600.57344408
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55483929
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55419101
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54926207
122Vitamin B6 metabolism_Homo sapiens_hsa007500.53608912
123Glutathione metabolism_Homo sapiens_hsa004800.52726318
124Circadian rhythm_Homo sapiens_hsa047100.52169772
125Pathways in cancer_Homo sapiens_hsa052000.52039139
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51349802
127Arginine and proline metabolism_Homo sapiens_hsa003300.50030283
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49373002
129HIF-1 signaling pathway_Homo sapiens_hsa040660.48502587
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47717871
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46955498
132RNA degradation_Homo sapiens_hsa030180.46761999
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.46698498
134Melanoma_Homo sapiens_hsa052180.46511232
135Vitamin digestion and absorption_Homo sapiens_hsa049770.46475529
136Metabolic pathways_Homo sapiens_hsa011000.46073802
137Nucleotide excision repair_Homo sapiens_hsa034200.45583206
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45093314
139Tight junction_Homo sapiens_hsa045300.44139017
140Phototransduction_Homo sapiens_hsa047440.43868056
141Prolactin signaling pathway_Homo sapiens_hsa049170.43823228
142Taste transduction_Homo sapiens_hsa047420.42842528
143mRNA surveillance pathway_Homo sapiens_hsa030150.40824851
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38241364
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37709537
146Regulation of autophagy_Homo sapiens_hsa041400.37617097
147Fanconi anemia pathway_Homo sapiens_hsa034600.36729385
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36534028
149Bladder cancer_Homo sapiens_hsa052190.35755611
150Allograft rejection_Homo sapiens_hsa053300.34197611
151FoxO signaling pathway_Homo sapiens_hsa040680.33785513
152Influenza A_Homo sapiens_hsa051640.33578101
153Fatty acid metabolism_Homo sapiens_hsa012120.32483427
154Endometrial cancer_Homo sapiens_hsa052130.30930718
155Serotonergic synapse_Homo sapiens_hsa047260.30624846
156Graft-versus-host disease_Homo sapiens_hsa053320.30508320
157p53 signaling pathway_Homo sapiens_hsa041150.29836973
158Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29784566
159Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28911852
160Autoimmune thyroid disease_Homo sapiens_hsa053200.28671214
161Collecting duct acid secretion_Homo sapiens_hsa049660.27677277

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