STK39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)4.93347055
2axon ensheathment in central nervous system (GO:0032291)4.93347055
3cilium or flagellum-dependent cell motility (GO:0001539)4.24404153
4acrosome reaction (GO:0007340)4.12059414
5negative regulation of inclusion body assembly (GO:0090084)3.97382747
6fusion of sperm to egg plasma membrane (GO:0007342)3.95915039
7axon ensheathment (GO:0008366)3.71692912
8ensheathment of neurons (GO:0007272)3.71692912
9sperm motility (GO:0030317)3.68108955
10myelination (GO:0042552)3.67920313
11acrosome assembly (GO:0001675)3.48242278
12sodium ion export (GO:0071436)3.45416941
13positive regulation of dendritic spine morphogenesis (GO:0061003)3.42723902
14regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.34996576
15sperm capacitation (GO:0048240)3.30378737
16cellular potassium ion homeostasis (GO:0030007)3.30087241
17cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.21187568
18regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.18827307
19plasma membrane fusion (GO:0045026)3.16679866
20multicellular organism reproduction (GO:0032504)3.15349494
21response to epinephrine (GO:0071871)3.15027497
22epithelial cilium movement (GO:0003351)3.14118140
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.13953587
24negative regulation of protein localization to cell surface (GO:2000009)3.13712431
25regulation of cell communication by electrical coupling (GO:0010649)3.09999489
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.09245039
27cellular response to epinephrine stimulus (GO:0071872)3.07047318
28establishment of mitochondrion localization (GO:0051654)3.04235499
29positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00567472
30embryonic retina morphogenesis in camera-type eye (GO:0060059)3.00278573
31protein retention in ER lumen (GO:0006621)3.00172548
32neuronal action potential propagation (GO:0019227)2.99409452
33fatty acid elongation (GO:0030497)2.99361106
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.98773906
35positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.98680328
36regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.98235374
37establishment of planar polarity (GO:0001736)2.96934957
38establishment of tissue polarity (GO:0007164)2.96934957
39skin morphogenesis (GO:0043589)2.96202957
40positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.96101504
41maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.95039119
42axonemal dynein complex assembly (GO:0070286)2.93642368
43myelin maintenance (GO:0043217)2.93363205
44calcium ion-dependent exocytosis (GO:0017156)2.93276948
45photoreceptor cell differentiation (GO:0046530)2.92495530
46eye photoreceptor cell differentiation (GO:0001754)2.92495530
47desmosome organization (GO:0002934)2.91600836
48* negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.91129030
49piRNA metabolic process (GO:0034587)2.89060540
50cell communication involved in cardiac conduction (GO:0086065)2.87246209
51positive regulation of potassium ion transmembrane transport (GO:1901381)2.86704143
52neuron cell-cell adhesion (GO:0007158)2.86490848
53cerebellar granule cell differentiation (GO:0021707)2.86079630
54regulation of actin filament-based movement (GO:1903115)2.84923369
55apical protein localization (GO:0045176)2.84654018
56camera-type eye morphogenesis (GO:0048593)2.83955118
57regulation of membrane repolarization (GO:0060306)2.83776595
58cilium movement (GO:0003341)2.83217638
59asymmetric protein localization (GO:0008105)2.83024167
60cell communication by electrical coupling (GO:0010644)2.83021650
61synaptic vesicle maturation (GO:0016188)2.82201403
62* negative regulation of potassium ion transmembrane transport (GO:1901380)2.81493146
63cardiac myofibril assembly (GO:0055003)2.80604922
64regulation of voltage-gated calcium channel activity (GO:1901385)2.79564341
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.77101050
66long-chain fatty acid biosynthetic process (GO:0042759)2.76984196
67regulation of cardiac muscle cell contraction (GO:0086004)2.73645808
68membrane repolarization (GO:0086009)2.73513222
69negative regulation of neurotransmitter transport (GO:0051589)2.73032863
70membrane repolarization during action potential (GO:0086011)2.71332297
71reproduction (GO:0000003)2.68456805
72sarcomere organization (GO:0045214)2.67581619
73regulation of synaptic vesicle exocytosis (GO:2000300)2.65283226
74protein localization to endosome (GO:0036010)2.64936034
75mating behavior (GO:0007617)2.64347272
76ventricular system development (GO:0021591)2.64334246
77regulation of calcium ion transmembrane transport (GO:1903169)2.64091720
78regulation of calcium ion transmembrane transporter activity (GO:1901019)2.64091720
79potassium ion import (GO:0010107)2.63838977
80membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.62316993
81sperm-egg recognition (GO:0035036)2.61126510
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.60393472
83negative regulation of neurotransmitter secretion (GO:0046929)2.59745933
84synaptic vesicle exocytosis (GO:0016079)2.58512286
85regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57592569
86peptidyl-tyrosine autophosphorylation (GO:0038083)2.57037097
87transmission of nerve impulse (GO:0019226)2.56806197
88regulation of NFAT protein import into nucleus (GO:0051532)2.56496302
89substantia nigra development (GO:0021762)2.55677063
90ventricular cardiac muscle cell action potential (GO:0086005)2.55619079
91layer formation in cerebral cortex (GO:0021819)2.55183830
92glutamate secretion (GO:0014047)2.53039830
93regulation of relaxation of muscle (GO:1901077)2.51225550
94regulation of inclusion body assembly (GO:0090083)2.50775145
95neuronal ion channel clustering (GO:0045161)2.50435603
96cellular response to catecholamine stimulus (GO:0071870)2.49317255
97cellular response to monoamine stimulus (GO:0071868)2.49317255
98regulation of neuronal synaptic plasticity (GO:0048168)2.48432416
99microtubule severing (GO:0051013)2.48099390
100spermatid development (GO:0007286)2.47515841
101response to monoamine (GO:0071867)2.47345635
102response to catecholamine (GO:0071869)2.47345635
103cell wall macromolecule catabolic process (GO:0016998)2.47208196
104cell wall macromolecule metabolic process (GO:0044036)2.47208196
105myelination in peripheral nervous system (GO:0022011)2.46933188
106peripheral nervous system axon ensheathment (GO:0032292)2.46933188
107membrane depolarization during action potential (GO:0086010)2.46628180
108neuron recognition (GO:0008038)2.46586001
109bundle of His cell to Purkinje myocyte communication (GO:0086069)2.46468915
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.46369536
111* positive regulation of potassium ion transport (GO:0043268)2.46102838
112myofibril assembly (GO:0030239)2.45663759
113cytoskeletal anchoring at plasma membrane (GO:0007016)2.45493679
114protein targeting to Golgi (GO:0000042)2.45365950
115negative regulation of organelle assembly (GO:1902116)2.44957620
116negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.44755167
117negative regulation of vascular permeability (GO:0043116)2.43973206
118positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.43252150
119epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42465621
120negative regulation of dendrite morphogenesis (GO:0050774)2.42393092
121regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.41373794
122axonal fasciculation (GO:0007413)2.41065902
123planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40754729
124regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39616844
125hippo signaling (GO:0035329)2.39014722
126establishment of nucleus localization (GO:0040023)2.38698020
127regulation of cholesterol biosynthetic process (GO:0045540)2.37575707
128cellular sodium ion homeostasis (GO:0006883)2.35586421
129pattern specification involved in kidney development (GO:0061004)2.34186221
130mitotic sister chromatid cohesion (GO:0007064)2.33325745
131developmental cell growth (GO:0048588)2.31150817
132negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.30404118
133cellular response to prostaglandin stimulus (GO:0071379)2.29603736
134regulation of synaptic vesicle transport (GO:1902803)2.28457702
135positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.27601879
136myoblast fusion (GO:0007520)2.26284068
137receptor recycling (GO:0001881)2.24893049
138positive regulation of glucose transport (GO:0010828)2.24673145
139cellular protein complex localization (GO:0034629)2.23547353
140paraxial mesoderm development (GO:0048339)2.22913214
141positive regulation of cell size (GO:0045793)2.22876634
142coronary vasculature morphogenesis (GO:0060977)2.22845435
143positive regulation of dendrite morphogenesis (GO:0050775)2.22271699
144lung epithelium development (GO:0060428)2.19392865
145regulation of establishment of planar polarity (GO:0090175)2.16204924
146auditory receptor cell differentiation (GO:0042491)2.15445701
147Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.14695073
148peptidyl-threonine dephosphorylation (GO:0035970)2.12184501
149positive regulation of dendritic spine development (GO:0060999)2.11991218
150ephrin receptor signaling pathway (GO:0048013)2.11082498
151regulation of ARF protein signal transduction (GO:0032012)2.11017681
152keratinocyte proliferation (GO:0043616)2.10789439
153histone H2B ubiquitination (GO:0033523)2.10559888
154establishment or maintenance of bipolar cell polarity (GO:0061245)2.10231782
155establishment or maintenance of apical/basal cell polarity (GO:0035088)2.10231782
156regulation of endothelial cell chemotaxis (GO:2001026)2.09768656
157regulation of axon extension involved in axon guidance (GO:0048841)2.09662356
158cerebral cortex neuron differentiation (GO:0021895)2.09303642
159insulin-like growth factor receptor signaling pathway (GO:0048009)2.09227180
160locomotory exploration behavior (GO:0035641)2.08145278
161eye morphogenesis (GO:0048592)2.05487317
162positive regulation of synapse maturation (GO:0090129)2.04933854
163positive regulation of neurological system process (GO:0031646)2.04575594
164potassium ion homeostasis (GO:0055075)2.04257064
165regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.03897961
166hemidesmosome assembly (GO:0031581)2.03466632
167amino acid import (GO:0043090)2.02501155
168cell adhesion mediated by integrin (GO:0033627)2.02122363
169activation of Rac GTPase activity (GO:0032863)2.01579329
170adherens junction assembly (GO:0034333)2.00708611
171positive regulation of cellular response to insulin stimulus (GO:1900078)2.00445905
172cochlea morphogenesis (GO:0090103)1.99768858
173regulation of dendritic spine morphogenesis (GO:0061001)1.99663145
174skeletal muscle organ development (GO:0060538)1.99363405
175dichotomous subdivision of an epithelial terminal unit (GO:0060600)1.99325729
176cerebral cortex radially oriented cell migration (GO:0021799)1.98958788
177establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)1.98310261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.89360519
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.40771895
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.08823454
4AR_21909140_ChIP-Seq_LNCAP_Human2.69369737
5GBX2_23144817_ChIP-Seq_PC3_Human2.54559115
6TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.44114203
7* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32590843
8* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.31129550
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.27613628
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23641257
11* CTNNB1_20460455_ChIP-Seq_HCT116_Human2.22811271
12* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.13348719
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07229640
14* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04960934
15* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04960934
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00850630
17* EP300_21415370_ChIP-Seq_HL-1_Mouse1.99813533
18* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98006626
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97685272
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.96603607
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95486593
22DROSHA_22980978_ChIP-Seq_HELA_Human1.91717287
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87182850
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.86786125
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.86640425
26TAF15_26573619_Chip-Seq_HEK293_Human1.86110436
27* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.84308137
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74946532
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.74592133
30* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73807846
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72110286
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.67581004
33KDM2B_26808549_Chip-Seq_K562_Human1.66723189
34CLOCK_20551151_ChIP-Seq_293T_Human1.65780205
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64643360
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.64395439
37DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63955164
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63076986
39* FOXO3_23340844_ChIP-Seq_DLD1_Human1.62119506
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.57804909
41HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57157015
42ZNF274_21170338_ChIP-Seq_K562_Hela1.55093157
43YAP1_20516196_ChIP-Seq_MESCs_Mouse1.53639932
44REST_21632747_ChIP-Seq_MESCs_Mouse1.53235808
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49559131
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49127957
47VDR_22108803_ChIP-Seq_LS180_Human1.47313646
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46140061
49FOXA2_19822575_ChIP-Seq_HepG2_Human1.45963156
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.44558119
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.43901321
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41037859
53SMAD4_21799915_ChIP-Seq_A2780_Human1.40811793
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40521749
55AR_21572438_ChIP-Seq_LNCaP_Human1.39380734
56PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39253838
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.36701486
58SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36499275
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.34197543
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33808477
61ZFP57_27257070_Chip-Seq_ESCs_Mouse1.33370038
62NFIB_24661679_ChIP-Seq_LUNG_Mouse1.32605322
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32452381
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31757259
65SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30847140
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30828794
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.30485877
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29507346
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.27831098
70CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26245439
71KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26055667
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25710096
73ISL1_27105846_Chip-Seq_CPCs_Mouse1.25515788
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24614309
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.23971874
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21921692
77AHR_22903824_ChIP-Seq_MCF-7_Human1.21086919
78* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21041430
79ER_23166858_ChIP-Seq_MCF-7_Human1.20094681
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18884194
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18096784
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18013909
83FOXM1_23109430_ChIP-Seq_U2OS_Human1.17678077
84TP53_16413492_ChIP-PET_HCT116_Human1.17237953
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16167118
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16109146
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15913751
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15820780
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.15760992
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.15622142
91* STAT3_23295773_ChIP-Seq_U87_Human1.13870068
92ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13673121
93GATA1_26923725_Chip-Seq_HPCs_Mouse1.13165879
94ZNF263_19887448_ChIP-Seq_K562_Human1.13004491
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13003268
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12833888
97REST_18959480_ChIP-ChIP_MESCs_Mouse1.12739206
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12143382
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11550651
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11500230
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11223987
102* TCF4_23295773_ChIP-Seq_U87_Human1.10091430
103* PIAS1_25552417_ChIP-Seq_VCAP_Human1.09956550
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.09781653
105TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09712007
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08390580
107P300_19829295_ChIP-Seq_ESCs_Human1.07961868
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07377421
109* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07345536
110PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06686815
111* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06673590
112TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06629411
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06569826
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05920946
115STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05156795
116* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04488043
117* CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03940184
118* SOX2_21211035_ChIP-Seq_LN229_Gbm1.03613849
119SMAD4_21741376_ChIP-Seq_EPCs_Human1.02351330
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.02189493
121ESR1_20079471_ChIP-ChIP_T-47D_Human1.02166817
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01846816
123KDM2B_26808549_Chip-Seq_JURKAT_Human1.01416669
124TRIM28_21343339_ChIP-Seq_HEK293_Human1.01264954
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00378388
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00269485
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00269485
128TCF4_18268006_ChIP-ChIP_LS174T_Human0.98272161
129KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.96910169
130ERG_21242973_ChIP-ChIP_JURKAT_Human0.96294732
131KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95541957
132FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95449694
133PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93357960
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92826958
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92781556
136RNF2_27304074_Chip-Seq_NSC_Mouse0.92659485
137* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92257524
138PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90964135
139LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90120535
140AR_19668381_ChIP-Seq_PC3_Human0.89866589
141SMAD3_21741376_ChIP-Seq_ESCs_Human0.89710360
142FUS_26573619_Chip-Seq_HEK293_Human0.89698788
143* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.89363941
144* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89213635
145* TBX20_22080862_ChIP-Seq_HEART_Mouse0.88666958
146* TBX20_22328084_ChIP-Seq_HEART_Mouse0.88666958
147KDM2B_26808549_Chip-Seq_REH_Human0.88499467
148RING1B_27294783_Chip-Seq_NPCs_Mouse0.88400258
149* PRDM14_20953172_ChIP-Seq_ESCs_Human0.88253534
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.87884783
151TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86535239
152FLI1_21867929_ChIP-Seq_TH2_Mouse0.86341184
153TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.85537766
154ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84951957
155CBP_20019798_ChIP-Seq_JUKART_Human0.84581648

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.47064441
2MP0000566_synostosis4.09964506
3MP0003880_abnormal_central_pattern3.62413982
4MP0004859_abnormal_synaptic_plasticity3.13482296
5MP0004270_analgesia2.99254973
6MP0010234_abnormal_vibrissa_follicle2.97621045
7MP0005409_darkened_coat_color2.74801412
8MP0004084_abnormal_cardiac_muscle2.65366542
9MP0000920_abnormal_myelination2.58733022
10MP0003123_paternal_imprinting2.51136660
11MP0000751_myopathy2.50548314
12MP0005623_abnormal_meninges_morphology2.50218121
13MP0002837_dystrophic_cardiac_calcinosis2.40823593
14MP0004036_abnormal_muscle_relaxation2.25705449
15MP0003635_abnormal_synaptic_transmissio2.25675459
16MP0003705_abnormal_hypodermis_morpholog2.17609716
17MP0009046_muscle_twitch2.14129284
18MP0002272_abnormal_nervous_system2.11057249
19MP0004185_abnormal_adipocyte_glucose2.10595922
20MP0004215_abnormal_myocardial_fiber2.07771807
21MP0003329_amyloid_beta_deposits1.93817225
22MP0002064_seizures1.89932986
23MP0001486_abnormal_startle_reflex1.89327027
24MP0009745_abnormal_behavioral_response1.81088687
25MP0002734_abnormal_mechanical_nocicepti1.80507468
26MP0010368_abnormal_lymphatic_system1.74145440
27MP0000778_abnormal_nervous_system1.73101663
28MP0005076_abnormal_cell_differentiation1.71408140
29MP0003137_abnormal_impulse_conducting1.67949065
30MP0002063_abnormal_learning/memory/cond1.65978861
31MP0000762_abnormal_tongue_morphology1.64460421
32MP0001968_abnormal_touch/_nociception1.64226407
33MP0005330_cardiomyopathy1.60214563
34MP0001485_abnormal_pinna_reflex1.58289757
35MP0003950_abnormal_plasma_membrane1.57138281
36MP0002735_abnormal_chemical_nociception1.56449339
37MP0004885_abnormal_endolymph1.54785471
38MP0009053_abnormal_anal_canal1.54735061
39MP0003646_muscle_fatigue1.54032632
40MP0002972_abnormal_cardiac_muscle1.53817142
41MP0004145_abnormal_muscle_electrophysio1.53589577
42MP0003698_abnormal_male_reproductive1.52565587
43MP0005171_absent_coat_pigmentation1.52188283
44MP0004085_abnormal_heartbeat1.52083907
45MP0003566_abnormal_cell_adhesion1.48997128
46MP0001529_abnormal_vocalization1.47910137
47MP0000749_muscle_degeneration1.47572429
48MP0001905_abnormal_dopamine_level1.47309152
49MP0002572_abnormal_emotion/affect_behav1.45787161
50MP0004742_abnormal_vestibular_system1.43068865
51MP0001299_abnormal_eye_distance/1.42261816
52MP0003634_abnormal_glial_cell1.41628076
53MP0003942_abnormal_urinary_system1.40611097
54MP0002089_abnormal_postnatal_growth/wei1.39120939
55MP0002067_abnormal_sensory_capabilities1.38810584
56MP0008569_lethality_at_weaning1.37615829
57MP0002009_preneoplasia1.37383656
58MP0005423_abnormal_somatic_nervous1.37251766
59MP0001440_abnormal_grooming_behavior1.37189832
60MP0004233_abnormal_muscle_weight1.36096837
61MP0005257_abnormal_intraocular_pressure1.34907458
62MP0005386_behavior/neurological_phenoty1.34886781
63MP0004924_abnormal_behavior1.34886781
64MP0004484_altered_response_of1.33967697
65MP0003315_abnormal_perineum_morphology1.33225016
66MP0004087_abnormal_muscle_fiber1.30849726
67MP0005620_abnormal_muscle_contractility1.30652949
68MP0000955_abnormal_spinal_cord1.29279540
69MP0001970_abnormal_pain_threshold1.27062769
70MP0002877_abnormal_melanocyte_morpholog1.26527771
71MP0002736_abnormal_nociception_after1.26015815
72MP0002733_abnormal_thermal_nociception1.26002655
73MP0008775_abnormal_heart_ventricle1.24554599
74MP0006138_congestive_heart_failure1.21851456
75MP0002882_abnormal_neuron_morphology1.21614402
76MP0003937_abnormal_limbs/digits/tail_de1.21610886
77MP0004043_abnormal_pH_regulation1.21173015
78MP0005666_abnormal_adipose_tissue1.20707083
79MP0010352_gastrointestinal_tract_polyps1.19470335
80MP0002229_neurodegeneration1.17911403
81MP0000747_muscle_weakness1.17813686
82MP0002184_abnormal_innervation1.17255661
83MP0003690_abnormal_glial_cell1.15160627
84MP0003861_abnormal_nervous_system1.15020197
85MP0006276_abnormal_autonomic_nervous1.14963578
86MP0002233_abnormal_nose_morphology1.13071602
87MP0004858_abnormal_nervous_system1.12731220
88MP0004272_abnormal_basement_membrane1.12507395
89MP0002896_abnormal_bone_mineralization1.11029305
90MP0009780_abnormal_chondrocyte_physiolo1.10256037
91MP0002249_abnormal_larynx_morphology1.09924079
92MP0003385_abnormal_body_wall1.08100774
93MP0001879_abnormal_lymphatic_vessel1.06778077
94MP0002066_abnormal_motor_capabilities/c1.06644017
95MP0001348_abnormal_lacrimal_gland1.05690185
96MP0009384_cardiac_valve_regurgitation1.04718372
97MP0002697_abnormal_eye_size1.04035709
98MP0002822_catalepsy1.03130312
99MP0003879_abnormal_hair_cell1.03092448
100MP0003091_abnormal_cell_migration1.03036226
101MP0010030_abnormal_orbit_morphology0.99930417
102MP0000432_abnormal_head_morphology0.99255858
103* MP0004811_abnormal_neuron_physiology0.99251972
104MP0003631_nervous_system_phenotype0.98601032
105MP0008877_abnormal_DNA_methylation0.98234963
106MP0003890_abnormal_embryonic-extraembry0.97601747
107MP0000579_abnormal_nail_morphology0.97383586
108MP0003633_abnormal_nervous_system0.97249992
109MP0002909_abnormal_adrenal_gland0.97199624
110MP0001929_abnormal_gametogenesis0.96484734
111MP0003632_abnormal_nervous_system0.95821038
112MP0002084_abnormal_developmental_patter0.95417556
113MP0004142_abnormal_muscle_tone0.94858371
114MP0010630_abnormal_cardiac_muscle0.94399300
115MP0001544_abnormal_cardiovascular_syste0.93845581
116MP0005385_cardiovascular_system_phenoty0.93845581
117MP0002106_abnormal_muscle_physiology0.92617470
118MP0010678_abnormal_skin_adnexa0.91597088
119MP0005551_abnormal_eye_electrophysiolog0.91475536
120MP0000428_abnormal_craniofacial_morphol0.91426535
121MP0008438_abnormal_cutaneous_collagen0.90961229
122MP0000733_abnormal_muscle_development0.90838323
123MP0009379_abnormal_foot_pigmentation0.90736939
124MP0001177_atelectasis0.90708710
125MP0002116_abnormal_craniofacial_bone0.90163159
126MP0000534_abnormal_ureter_morphology0.89904664
127MP0002557_abnormal_social/conspecific_i0.89245188
128MP0000537_abnormal_urethra_morphology0.88378077
129MP0002752_abnormal_somatic_nervous0.87733669
130MP0005369_muscle_phenotype0.87176334
131MP0003115_abnormal_respiratory_system0.86178441
132MP0009250_abnormal_appendicular_skeleto0.85745714
133MP0000467_abnormal_esophagus_morphology0.85665454
134MP0001501_abnormal_sleep_pattern0.85244362
135MP0001286_abnormal_eye_development0.84870275
136MP0003935_abnormal_craniofacial_develop0.83357921
137MP0002152_abnormal_brain_morphology0.83206697
138MP0003122_maternal_imprinting0.83141297
139MP0003755_abnormal_palate_morphology0.82345219
140MP0000759_abnormal_skeletal_muscle0.81276181
141MP0004130_abnormal_muscle_cell0.81268126
142MP0001963_abnormal_hearing_physiology0.80229686
143MP0002234_abnormal_pharynx_morphology0.78931312
144MP0002108_abnormal_muscle_morphology0.78395182
145MP0001730_embryonic_growth_arrest0.77977943
146MP0004510_myositis0.76515268
147MP0004264_abnormal_extraembryonic_tissu0.76031002
148MP0000462_abnormal_digestive_system0.76011073
149MP0002081_perinatal_lethality0.75928764
150MP0002114_abnormal_axial_skeleton0.73972456
151MP0005375_adipose_tissue_phenotype0.73399405
152MP0004134_abnormal_chest_morphology0.73266521
153MP0005187_abnormal_penis_morphology0.73233635
154MP0002269_muscular_atrophy0.71997112
155MP0003121_genomic_imprinting0.71892047
156MP0002085_abnormal_embryonic_tissue0.71744486
157MP0001502_abnormal_circadian_rhythm0.71485017
158MP0005503_abnormal_tendon_morphology0.71400706
159MP0001915_intracranial_hemorrhage0.70776124
160MP0002086_abnormal_extraembryonic_tissu0.70633163
161MP0001340_abnormal_eyelid_morphology0.70583879
162MP0003119_abnormal_digestive_system0.69545128

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.06818524
2Dynein arm defect of respiratory motile cilia (HP:0012255)4.91883716
3Absent/shortened dynein arms (HP:0200106)4.91883716
4Sudden death (HP:0001699)3.88301500
5Termporal pattern (HP:0011008)3.84547719
6Insidious onset (HP:0003587)3.84547719
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.72575417
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.72575417
9Myokymia (HP:0002411)3.65421835
10Abnormal respiratory motile cilium physiology (HP:0012261)3.50614564
11Pheochromocytoma (HP:0002666)3.40954216
12Peripheral hypomyelination (HP:0007182)3.40188309
13Neurofibrillary tangles (HP:0002185)3.38586973
14Ventricular fibrillation (HP:0001663)3.25002274
15Vertebral arch anomaly (HP:0008438)3.22649060
16Hyporeflexia of lower limbs (HP:0002600)3.15068082
17Abnormality of the corticospinal tract (HP:0002492)3.07204330
18Syncope (HP:0001279)3.01775950
19Supranuclear gaze palsy (HP:0000605)2.96888035
20Neonatal short-limb short stature (HP:0008921)2.96760830
21Cerebral inclusion bodies (HP:0100314)2.94166524
22Action tremor (HP:0002345)2.93904184
23Atrial fibrillation (HP:0005110)2.92123462
24Abnormal respiratory epithelium morphology (HP:0012253)2.92040079
25Abnormal respiratory motile cilium morphology (HP:0005938)2.92040079
26Prolonged QT interval (HP:0001657)2.90743764
27Abnormal ciliary motility (HP:0012262)2.88511600
28Neuroendocrine neoplasm (HP:0100634)2.88052337
29Muscle fiber splitting (HP:0003555)2.88050729
30Sensory axonal neuropathy (HP:0003390)2.82308356
31Ulnar claw (HP:0001178)2.81975808
32Bundle branch block (HP:0011710)2.78169155
33Muscle hypertrophy of the lower extremities (HP:0008968)2.76934951
34Onion bulb formation (HP:0003383)2.76574641
35Primary atrial arrhythmia (HP:0001692)2.74960598
36Calf muscle hypertrophy (HP:0008981)2.72007406
37Rhinitis (HP:0012384)2.68353179
38Protrusio acetabuli (HP:0003179)2.65676138
39Obstructive sleep apnea (HP:0002870)2.63139616
40Ankle clonus (HP:0011448)2.59637157
41Supraventricular tachycardia (HP:0004755)2.55461022
42Foot dorsiflexor weakness (HP:0009027)2.52123144
43Arterial tortuosity (HP:0005116)2.51300571
44Supraventricular arrhythmia (HP:0005115)2.50953639
45Abnormality of the calf musculature (HP:0001430)2.49685464
46Vascular tortuosity (HP:0004948)2.49582451
47Focal motor seizures (HP:0011153)2.47699924
48Flat acetabular roof (HP:0003180)2.45183008
49Insomnia (HP:0100785)2.43603279
50Abnormality of the foot musculature (HP:0001436)2.42269595
51Spastic gait (HP:0002064)2.40861505
52Shallow orbits (HP:0000586)2.38317473
53Coronal craniosynostosis (HP:0004440)2.38144599
54Exercise-induced myalgia (HP:0003738)2.37588238
55Dysmetria (HP:0001310)2.37349786
56Segmental peripheral demyelination/remyelination (HP:0003481)2.35773945
57Decreased motor nerve conduction velocity (HP:0003431)2.34281456
58Hammertoe (HP:0001765)2.31121472
59Exercise-induced muscle cramps (HP:0003710)2.30973547
60Retinal dysplasia (HP:0007973)2.28308242
61Steppage gait (HP:0003376)2.27756664
62Papillary thyroid carcinoma (HP:0002895)2.24850344
63Atonic seizures (HP:0010819)2.24729113
64Urinary urgency (HP:0000012)2.22952346
65Infertility (HP:0000789)2.22812724
66Focal seizures (HP:0007359)2.19911197
67Ventricular tachycardia (HP:0004756)2.19180069
68Long palpebral fissure (HP:0000637)2.17857729
69Missing ribs (HP:0000921)2.14654127
70Progressive cerebellar ataxia (HP:0002073)2.14188487
71Overgrowth (HP:0001548)2.10229828
72Intention tremor (HP:0002080)2.09462719
73Ventricular arrhythmia (HP:0004308)2.08102897
74Abnormal EKG (HP:0003115)2.07585074
75Abnormality of carpal bone ossification (HP:0006257)2.07371486
76Pterygium (HP:0001059)2.06909615
77Mitral regurgitation (HP:0001653)2.05670892
78Lower limb muscle weakness (HP:0007340)2.04435822
79Gaze-evoked nystagmus (HP:0000640)2.04131523
80Atrophic scars (HP:0001075)2.03721878
81Chronic bronchitis (HP:0004469)2.03627839
82Megalencephaly (HP:0001355)2.02923575
83Cortical dysplasia (HP:0002539)2.01200586
84Cerebral hemorrhage (HP:0001342)2.00540283
85Buphthalmos (HP:0000557)1.99177128
86Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.97509789
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.96649685
88Vertebral hypoplasia (HP:0008417)1.96649685
89Difficulty running (HP:0009046)1.96619788
90Dysmetric saccades (HP:0000641)1.94886297
91Febrile seizures (HP:0002373)1.94851526
92Progressive inability to walk (HP:0002505)1.94448684
93Abnormal auditory evoked potentials (HP:0006958)1.94242439
94Premature rupture of membranes (HP:0001788)1.93076458
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.91946232
96Aplasia involving bones of the extremities (HP:0009825)1.90807414
97Aplasia involving bones of the upper limbs (HP:0009823)1.90807414
98Aplasia of the phalanges of the hand (HP:0009802)1.90807414
99Epileptic encephalopathy (HP:0200134)1.90166458
100Increased serum pyruvate (HP:0003542)1.87223796
101Abnormality of glycolysis (HP:0004366)1.87223796
102Arnold-Chiari malformation (HP:0002308)1.86472156
103Hyperacusis (HP:0010780)1.85826949
104EMG: myopathic abnormalities (HP:0003458)1.85265120
105Ankyloglossia (HP:0010296)1.85059964
106Leukodystrophy (HP:0002415)1.84765807
107Abnormality of dentin (HP:0010299)1.83725470
108Anal stenosis (HP:0002025)1.80768660
109Neoplasm of the peripheral nervous system (HP:0100007)1.79963791
110Preauricular pit (HP:0004467)1.79722184
111Periauricular skin pits (HP:0100277)1.79722184
112Scanning speech (HP:0002168)1.79288826
113Distal sensory impairment (HP:0002936)1.77361975
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.76949461
115Limb dystonia (HP:0002451)1.76365756
116Asymmetry of the thorax (HP:0001555)1.76099714
117Type II lissencephaly (HP:0007260)1.75611295
118Truncal ataxia (HP:0002078)1.75165784
119Right ventricular cardiomyopathy (HP:0011663)1.74826350
120Uterine leiomyosarcoma (HP:0002891)1.73106804
121Leiomyosarcoma (HP:0100243)1.73106804
122Rapidly progressive (HP:0003678)1.72890597
123Sparse lateral eyebrow (HP:0005338)1.72818451
124Lipoatrophy (HP:0100578)1.72805570
125Acute necrotizing encephalopathy (HP:0006965)1.72643504
126Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72363550
127Hypoplasia of the brainstem (HP:0002365)1.72363550
128Transposition of the great arteries (HP:0001669)1.72304592
129Abnormal connection of the cardiac segments (HP:0011545)1.72304592
130Abnormal ventriculo-arterial connection (HP:0011563)1.72304592
131Abnormal ossification of hand bones (HP:0005921)1.72052347
132Increased nuchal translucency (HP:0010880)1.71943529
133Omphalocele (HP:0001539)1.71069394
134Distal upper limb amyotrophy (HP:0007149)1.70423593
135Upper limb amyotrophy (HP:0009129)1.70423593
136Abnormality of the phalanges of the hallux (HP:0010057)1.69333490
137Advanced eruption of teeth (HP:0006288)1.69310722
138Deep venous thrombosis (HP:0002625)1.69301489
139Abnormal hand bone ossification (HP:0010660)1.68390092
140Turricephaly (HP:0000262)1.68045255
141Slow progression (HP:0003677)1.67887748
142Dysdiadochokinesis (HP:0002075)1.67359052
143Hypoplasia of the iris (HP:0007676)1.66408737
144Hyperextensible skin (HP:0000974)1.66368845
145Aortic dissection (HP:0002647)1.66210706
146Abnormality of the distal phalanx of the thumb (HP:0009617)1.66020607
147Renal duplication (HP:0000075)1.65900326
148Skin pits (HP:0100276)1.65562847
149Heart block (HP:0012722)1.65361647
150Lip pit (HP:0100267)1.64923572
151Gowers sign (HP:0003391)1.64081688
152Increased circulating renin level (HP:0000848)1.63233637
153Bell-shaped thorax (HP:0001591)1.63105555
154Visual hallucinations (HP:0002367)1.62886351
155Absence seizures (HP:0002121)1.62375678
156Heterotopia (HP:0002282)1.62265577
157Spastic tetraparesis (HP:0001285)1.61792134
158Impaired vibration sensation in the lower limbs (HP:0002166)1.60219319
159Hepatoblastoma (HP:0002884)1.59878682
160Transitional cell carcinoma of the bladder (HP:0006740)1.59404604
161Abnormal tarsal ossification (HP:0008369)1.59129762
162Osteomalacia (HP:0002749)1.58838668
163Mask-like facies (HP:0000298)1.58128489
164Small epiphyses (HP:0010585)1.58042985
165Renal cell carcinoma (HP:0005584)1.57847014
166Lower limb asymmetry (HP:0100559)1.57123629
167Wide anterior fontanel (HP:0000260)1.56391623
168Germ cell neoplasia (HP:0100728)1.56001950
169Vertebral clefting (HP:0008428)1.55299385
170Bladder neoplasm (HP:0009725)1.55009362
171Bladder carcinoma (HP:0002862)1.55009362
172Aplasia/Hypoplasia of the scapulae (HP:0006713)1.54410498
173Hypoplastic scapulae (HP:0000882)1.54410498
174Pulmonic stenosis (HP:0001642)1.54311917
175Bronchomalacia (HP:0002780)1.53706639
176Abnormality of the lower motor neuron (HP:0002366)1.53642153
177Precocious puberty (HP:0000826)1.53003181
178Wormian bones (HP:0002645)1.52499192
179Intestinal fistula (HP:0100819)1.52437158
180Cubitus valgus (HP:0002967)1.51783038

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK43.83588284
2PDK33.83588284
3MST1R3.53296044
4* STK393.36419755
5OXSR12.87939038
6PRKD32.62829328
7LMTK22.62603192
8STK242.48320565
9PDK22.43897094
10ICK2.38087905
11PDGFRA2.17091486
12PNCK2.16122646
13EEF2K2.15349273
14RIPK12.01944033
15EPHB11.99868011
16EPHA21.98423492
17TRIB31.96473965
18TESK11.88969465
19CAMK1D1.85493236
20PTK2B1.84754984
21LIMK11.80458226
22NTRK11.78459257
23MAP3K91.77495135
24PAK61.75570306
25PHKG21.73544827
26PHKG11.73544827
27NTRK31.73248949
28LATS11.64626840
29MAP3K41.62941371
30MAPKAPK51.60028320
31CDK121.57671681
32UHMK11.56452554
33SIK11.54451841
34MINK11.49037036
35EPHB21.47545135
36BCR1.46833001
37PAK31.46091801
38TYRO31.45261493
39MARK11.40542089
40PKN11.38911402
41SCYL21.38350766
42PKN21.36599579
43KSR21.36429364
44AKT31.34296465
45DMPK1.30457506
46BRSK11.26549599
47FGFR21.25844161
48FGFR11.25274090
49* WNK11.24033378
50EPHA41.23271108
51ROCK21.20661234
52CAMK2D1.20424839
53CDK191.14811293
54STK381.14362680
55CAMK2A1.10330088
56MAP3K101.09332785
57KSR11.08898517
58RET1.08865753
59CDK51.05679416
60MET1.05145637
61CAMK2B1.00655264
62SGK4940.99632939
63SGK2230.99632939
64MYLK0.91820437
65PDPK10.91372651
66SGK30.91199705
67CAMK10.91051931
68PDK10.89741204
69MAP3K20.88305330
70NEK90.83712719
71CDK140.83612365
72CAMK1G0.83154192
73BRD40.83151759
74FGFR40.82292893
75MAP2K70.82005246
76NTRK20.81072031
77TTN0.80718037
78CSNK1G20.80419761
79MTOR0.79836510
80PRKD10.79633462
81PIK3CA0.79632611
82ERBB40.78993055
83CASK0.78648156
84OBSCN0.77847862
85SGK20.76730790
86MOS0.76615852
87MAP3K130.76341109
88STK38L0.75826520
89FGR0.75356804
90CAMK2G0.74501961
91CSNK1G30.74384015
92LATS20.74251462
93PAK20.74150031
94CCNB10.73847453
95CSNK1A1L0.72833106
96BRAF0.72622903
97FGFR30.72090940
98ROCK10.71843399
99NEK60.70593158
100GRK70.70290024
101FER0.69697273
102CDK150.69056320
103MST40.67892804
104PLK20.66804577
105MARK20.66603347
106PRKCE0.66523074
107CDK180.66090745
108GRK50.65485733
109DDR20.65276519
110MAP2K40.64693866
111PBK0.64600655
112STK110.64075208
113MAPK100.63446789
114DYRK1B0.62265990
115PRKCH0.61991607
116CDC42BPA0.61888639
117PINK10.61788607
118TNIK0.59347464
119CDK11A0.57230698
120WEE10.56341625
121CAMKK10.55703833
122ERBB20.52940552
123CSNK1E0.52359405
124PDGFRB0.52293311
125CSNK1G10.50594431
126MELK0.49997563
127BMPR1B0.49720182
128DAPK20.49665230
129CDK70.49097883
130MAPK130.47487345
131RPS6KB10.47205619
132CAMK40.46988097
133SMG10.46405645
134FYN0.46280251
135ARAF0.45466446
136SGK10.45145496
137IRAK20.45121810
138ILK0.44035404
139RPS6KA20.43878956
140PRKCG0.43536898
141PRPF4B0.43248885
142RPS6KB20.43184554
143* PRKCQ0.42729393
144MAP3K10.41801187
145WNK30.41067409
146YES10.40832972
147PRKACB0.39948307
148BMX0.39160391
149PTK20.38879281
150NEK20.35684207
151LRRK20.35427828

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042602.59581422
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.10020253
3Oxidative phosphorylation_Homo sapiens_hsa001902.08237447
4Parkinsons disease_Homo sapiens_hsa050121.91606381
5Adherens junction_Homo sapiens_hsa045201.86789196
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75960525
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.74330433
8Dorso-ventral axis formation_Homo sapiens_hsa043201.73285283
9Alzheimers disease_Homo sapiens_hsa050101.71999340
10Synaptic vesicle cycle_Homo sapiens_hsa047211.71500318
11Dilated cardiomyopathy_Homo sapiens_hsa054141.70370231
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70050476
13Long-term potentiation_Homo sapiens_hsa047201.67647248
14Gastric acid secretion_Homo sapiens_hsa049711.64649283
15Circadian entrainment_Homo sapiens_hsa047131.64572788
16Amphetamine addiction_Homo sapiens_hsa050311.63612697
17Glutamatergic synapse_Homo sapiens_hsa047241.58344194
18Hippo signaling pathway_Homo sapiens_hsa043901.57978927
19Fatty acid elongation_Homo sapiens_hsa000621.55671968
20Renin secretion_Homo sapiens_hsa049241.53280721
21Axon guidance_Homo sapiens_hsa043601.52534151
22Salivary secretion_Homo sapiens_hsa049701.52033236
23Dopaminergic synapse_Homo sapiens_hsa047281.50690196
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.44232148
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43277480
26Huntingtons disease_Homo sapiens_hsa050161.39291561
27GABAergic synapse_Homo sapiens_hsa047271.38752508
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.38630072
29Nicotine addiction_Homo sapiens_hsa050331.37378065
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36366396
31Propanoate metabolism_Homo sapiens_hsa006401.36194764
32Endometrial cancer_Homo sapiens_hsa052131.35695908
33Olfactory transduction_Homo sapiens_hsa047401.35577142
34Morphine addiction_Homo sapiens_hsa050321.32847768
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.31506247
36Cholinergic synapse_Homo sapiens_hsa047251.28217790
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.28011015
38Ether lipid metabolism_Homo sapiens_hsa005651.26872504
39Thyroid cancer_Homo sapiens_hsa052161.26583622
40Chronic myeloid leukemia_Homo sapiens_hsa052201.26008098
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23871934
42Cocaine addiction_Homo sapiens_hsa050301.20946384
43Insulin secretion_Homo sapiens_hsa049111.20607060
44Serotonergic synapse_Homo sapiens_hsa047261.19872960
45Proteoglycans in cancer_Homo sapiens_hsa052051.17667710
46Collecting duct acid secretion_Homo sapiens_hsa049661.17061901
47Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16695784
48Oxytocin signaling pathway_Homo sapiens_hsa049211.14839272
49Pyruvate metabolism_Homo sapiens_hsa006201.14437736
50Long-term depression_Homo sapiens_hsa047301.14416754
51Tight junction_Homo sapiens_hsa045301.14136140
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13328879
53AMPK signaling pathway_Homo sapiens_hsa041521.12688238
54Steroid biosynthesis_Homo sapiens_hsa001001.11830352
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.11474606
56Calcium signaling pathway_Homo sapiens_hsa040201.09708107
57Fatty acid biosynthesis_Homo sapiens_hsa000611.08105858
58Taste transduction_Homo sapiens_hsa047421.05790963
59Pancreatic secretion_Homo sapiens_hsa049721.05675884
60Non-small cell lung cancer_Homo sapiens_hsa052231.05566991
61mTOR signaling pathway_Homo sapiens_hsa041501.05519367
62MicroRNAs in cancer_Homo sapiens_hsa052061.04551863
63Vascular smooth muscle contraction_Homo sapiens_hsa042701.01890319
64Notch signaling pathway_Homo sapiens_hsa043301.01842264
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.01447668
66Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00652461
67Gap junction_Homo sapiens_hsa045400.99810630
68Insulin signaling pathway_Homo sapiens_hsa049100.99129748
69Prostate cancer_Homo sapiens_hsa052150.98633331
70Vibrio cholerae infection_Homo sapiens_hsa051100.98130860
71Basal cell carcinoma_Homo sapiens_hsa052170.97538971
72cAMP signaling pathway_Homo sapiens_hsa040240.97522966
73Renal cell carcinoma_Homo sapiens_hsa052110.97055351
74Estrogen signaling pathway_Homo sapiens_hsa049150.96931890
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.95299494
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95038868
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92161294
78Prion diseases_Homo sapiens_hsa050200.90333150
79Arginine biosynthesis_Homo sapiens_hsa002200.90023381
80Vitamin B6 metabolism_Homo sapiens_hsa007500.89413403
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.87054617
82Pancreatic cancer_Homo sapiens_hsa052120.86427768
83Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85385429
84ErbB signaling pathway_Homo sapiens_hsa040120.84696374
85Endocytosis_Homo sapiens_hsa041440.83648757
86Colorectal cancer_Homo sapiens_hsa052100.83020551
87GnRH signaling pathway_Homo sapiens_hsa049120.81649768
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81598733
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79788209
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79378799
91Arginine and proline metabolism_Homo sapiens_hsa003300.79119808
92Melanogenesis_Homo sapiens_hsa049160.78438910
93ECM-receptor interaction_Homo sapiens_hsa045120.76979037
94Bile secretion_Homo sapiens_hsa049760.76691404
95Glucagon signaling pathway_Homo sapiens_hsa049220.75417290
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74941344
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.74584982
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74445650
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74349408
100TGF-beta signaling pathway_Homo sapiens_hsa043500.72958183
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72730367
102Lysine degradation_Homo sapiens_hsa003100.71530116
103VEGF signaling pathway_Homo sapiens_hsa043700.70223257
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69885873
105Small cell lung cancer_Homo sapiens_hsa052220.68392380
106Oocyte meiosis_Homo sapiens_hsa041140.67350309
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67348595
108Melanoma_Homo sapiens_hsa052180.67207222
109Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66387773
110Fatty acid metabolism_Homo sapiens_hsa012120.66102155
111Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65738422
112Pathways in cancer_Homo sapiens_hsa052000.65701238
113Type II diabetes mellitus_Homo sapiens_hsa049300.65281159
114Ras signaling pathway_Homo sapiens_hsa040140.63067694
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.62225319
116Focal adhesion_Homo sapiens_hsa045100.61743129
117Phototransduction_Homo sapiens_hsa047440.61575713
118Thyroid hormone synthesis_Homo sapiens_hsa049180.60052556
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59929385
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59420285
121Protein digestion and absorption_Homo sapiens_hsa049740.58022398
122Hedgehog signaling pathway_Homo sapiens_hsa043400.57456197
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56870399
124Mineral absorption_Homo sapiens_hsa049780.56553183
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54642760
126Wnt signaling pathway_Homo sapiens_hsa043100.54553795
127Glioma_Homo sapiens_hsa052140.53890662
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53699229
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53012299
130MAPK signaling pathway_Homo sapiens_hsa040100.52051153
131Linoleic acid metabolism_Homo sapiens_hsa005910.49886608
132Choline metabolism in cancer_Homo sapiens_hsa052310.47716778
133Inositol phosphate metabolism_Homo sapiens_hsa005620.45878593
134Viral myocarditis_Homo sapiens_hsa054160.45273039
135Ovarian steroidogenesis_Homo sapiens_hsa049130.45229173
136Sulfur metabolism_Homo sapiens_hsa009200.43879964
137Rap1 signaling pathway_Homo sapiens_hsa040150.43027396
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42897383
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42852223

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