STK4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.02560513
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.23416955
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.23416955
4negative regulation of cell killing (GO:0031342)5.10624808
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.10624808
6antigen processing and presentation of endogenous antigen (GO:0019883)5.00118520
7negative T cell selection (GO:0043383)4.96821581
8negative thymic T cell selection (GO:0045060)4.85985617
9regulation of gamma-delta T cell differentiation (GO:0045586)4.82980084
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.59161053
11positive regulation by organism of defense response of other organism involved in symbiotic interact4.59161053
12modulation by symbiont of host immune response (GO:0052553)4.59161053
13positive regulation by symbiont of host defense response (GO:0052509)4.59161053
14modulation by symbiont of host defense response (GO:0052031)4.59161053
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.59161053
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.54485647
17regulation of gamma-delta T cell activation (GO:0046643)4.46995661
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30502472
19positive thymic T cell selection (GO:0045059)4.17060421
20negative regulation of T cell mediated immunity (GO:0002710)4.16588623
21NIK/NF-kappaB signaling (GO:0038061)4.09657763
22positive regulation of granulocyte differentiation (GO:0030854)4.01995006
23regulation of B cell receptor signaling pathway (GO:0050855)3.96051533
24T cell selection (GO:0045058)3.95257517
25thymic T cell selection (GO:0045061)3.90612905
26positive regulation of B cell differentiation (GO:0045579)3.90387487
27activated T cell proliferation (GO:0050798)3.87022742
28response to interleukin-15 (GO:0070672)3.86036169
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.84781505
30negative regulation of lymphocyte mediated immunity (GO:0002707)3.81239384
31macrophage activation involved in immune response (GO:0002281)3.79280693
32B cell receptor signaling pathway (GO:0050853)3.77526926
33regulation of interleukin-12 biosynthetic process (GO:0045075)3.77221940
34negative regulation of interleukin-12 production (GO:0032695)3.76202262
35T cell migration (GO:0072678)3.76098925
36regulation of B cell differentiation (GO:0045577)3.75677809
37positive T cell selection (GO:0043368)3.72946897
38microglial cell activation (GO:0001774)3.72509434
39leukocyte aggregation (GO:0070486)3.67506154
40detection of molecule of bacterial origin (GO:0032490)3.63833674
41detection of other organism (GO:0098543)3.57827322
42interferon-gamma production (GO:0032609)3.57001721
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.51534930
44regulation of interferon-beta biosynthetic process (GO:0045357)3.51211491
45cellular response to interleukin-15 (GO:0071350)3.50335035
46regulation of alpha-beta T cell proliferation (GO:0046640)3.43916637
47detection of external biotic stimulus (GO:0098581)3.32288664
48response to host immune response (GO:0052572)3.32034582
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32034582
50regulation of regulatory T cell differentiation (GO:0045589)3.30321056
51detection of bacterium (GO:0016045)3.28404515
52negative regulation of leukocyte mediated immunity (GO:0002704)3.28264551
53regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.26676430
54positive regulation of interleukin-2 production (GO:0032743)3.24242304
55T cell costimulation (GO:0031295)3.18753605
56myeloid cell activation involved in immune response (GO:0002275)3.18151937
57neutrophil activation involved in immune response (GO:0002283)3.16521298
58negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15695027
59neutrophil activation (GO:0042119)3.15149085
60Arp2/3 complex-mediated actin nucleation (GO:0034314)3.14604258
61positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.14280008
62positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13183067
63lymphocyte costimulation (GO:0031294)3.13164842
64regulation of tolerance induction (GO:0002643)3.12709060
65antigen receptor-mediated signaling pathway (GO:0050851)3.11837416
66myeloid dendritic cell activation (GO:0001773)3.11511521
67response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.10639087
68response to host (GO:0075136)3.10639087
69response to host defenses (GO:0052200)3.10639087
70neutrophil mediated immunity (GO:0002446)3.10512338
71negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09797429
72tolerance induction (GO:0002507)3.09591195
73regulation of T cell receptor signaling pathway (GO:0050856)3.07807692
74natural killer cell differentiation (GO:0001779)3.05815592
75regulation of T cell tolerance induction (GO:0002664)3.05069090
76T cell homeostasis (GO:0043029)3.04376782
77negative regulation of phagocytosis (GO:0050765)3.04253264
78detection of biotic stimulus (GO:0009595)3.03773946
79T cell receptor signaling pathway (GO:0050852)3.03543105
80respiratory burst (GO:0045730)3.03052519
81response to peptidoglycan (GO:0032494)3.02111466
82positive regulation of isotype switching (GO:0045830)3.01645828
83regulation of T cell mediated cytotoxicity (GO:0001914)3.01477105
84negative regulation of adaptive immune response (GO:0002820)3.00886282
85macrophage activation (GO:0042116)3.00781040
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.98689703
87negative regulation of T-helper cell differentiation (GO:0045623)2.98689703
88positive regulation of tolerance induction (GO:0002645)2.96837605
89natural killer cell activation (GO:0030101)2.94307057
90mast cell activation (GO:0045576)2.93092401
91dendritic cell migration (GO:0036336)2.92295352
92granulocyte activation (GO:0036230)2.91725871
93regulation of response to interferon-gamma (GO:0060330)2.88647255
94phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.88205468
95myeloid leukocyte mediated immunity (GO:0002444)2.87022846
96JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.85639127
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85410572
98cellular response to zinc ion (GO:0071294)2.85258326
99leukocyte cell-cell adhesion (GO:0007159)2.83240858
100interferon-gamma-mediated signaling pathway (GO:0060333)2.83142172
101immunoglobulin mediated immune response (GO:0016064)2.83110200
102antigen processing and presentation via MHC class Ib (GO:0002475)2.81216847
103regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.79846166
104lymphocyte homeostasis (GO:0002260)2.79675955
105regulation of interleukin-2 biosynthetic process (GO:0045076)2.79616163
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.76832106
107myeloid dendritic cell differentiation (GO:0043011)2.76806283
108response to type I interferon (GO:0034340)2.76480706
109regulation of isotype switching to IgG isotypes (GO:0048302)2.76400859
110type I interferon signaling pathway (GO:0060337)2.71318642
111cellular response to type I interferon (GO:0071357)2.71318642
112T cell proliferation (GO:0042098)2.71221170
113B cell mediated immunity (GO:0019724)2.68269529
114alpha-beta T cell activation (GO:0046631)2.67587265
115natural killer cell mediated cytotoxicity (GO:0042267)2.67550055
116natural killer cell mediated immunity (GO:0002228)2.67550055
117V(D)J recombination (GO:0033151)2.67444694
118regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64686426
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.64285662
120regulation of hypersensitivity (GO:0002883)2.63973740
121B cell proliferation (GO:0042100)2.62579666
122cellular extravasation (GO:0045123)2.62130395
123negative regulation of B cell proliferation (GO:0030889)2.61299864
124megakaryocyte development (GO:0035855)2.60545005
125B cell homeostasis (GO:0001782)2.58693444
126response to muramyl dipeptide (GO:0032495)2.57044853
127regulation of RIG-I signaling pathway (GO:0039535)2.56230022
128negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.56205395
129positive regulation of interferon-alpha production (GO:0032727)2.56160758
130positive regulation of antigen processing and presentation (GO:0002579)2.55011023
131mononuclear cell proliferation (GO:0032943)2.54067240
132regulation of necroptotic process (GO:0060544)2.53792415
133lymphocyte proliferation (GO:0046651)2.53522694
134response to protozoan (GO:0001562)2.53492409
135positive regulation of DNA recombination (GO:0045911)2.52170870
136positive regulation of natural killer cell differentiation (GO:0032825)2.51997959
137nuclear pore complex assembly (GO:0051292)2.51426052
138regulation of natural killer cell mediated immunity (GO:0002715)2.50318587
139regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.50318587
140immune response-activating cell surface receptor signaling pathway (GO:0002429)2.50305363
141defense response to protozoan (GO:0042832)2.49263239
142mature B cell differentiation (GO:0002335)2.48651054
143regulation of interferon-alpha production (GO:0032647)2.47560824
144positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.46666509
145T cell differentiation (GO:0030217)2.45971338

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.49790305
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.03686958
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.39913917
4* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.20762826
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.76150571
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.66151371
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.35734161
8MYC_22102868_ChIP-Seq_BL_Human3.23012982
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.13976331
10* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.92873693
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.84651149
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.77709731
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.76437694
14MYB_26560356_Chip-Seq_TH2_Human2.62508797
15* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.53598858
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50407536
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.49975988
18RUNX_20019798_ChIP-Seq_JUKART_Human2.47077841
19VDR_21846776_ChIP-Seq_THP-1_Human2.45068528
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.44727187
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41703673
22MAF_26560356_Chip-Seq_TH1_Human2.40507690
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38229877
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30824241
25SMAD_19615063_ChIP-ChIP_OVARY_Human2.28816254
26MYB_26560356_Chip-Seq_TH1_Human2.26636208
27* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23000941
28SCL_19346495_ChIP-Seq_HPC-7_Human2.22905278
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22808324
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.18314037
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.16911478
32* SPI1_23547873_ChIP-Seq_NB4_Human2.10220825
33UTX_26944678_Chip-Seq_JUKART_Human2.06532165
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.89135849
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.88636316
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87691341
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82428825
38VDR_24763502_ChIP-Seq_THP-1_Human1.81457300
39* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76988628
40VDR_24787735_ChIP-Seq_THP-1_Human1.68359522
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63138425
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62962919
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.61950573
44* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58521065
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54842574
46* GATA3_27048872_Chip-Seq_THYMUS_Human1.54695310
47* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54269544
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.53785510
49MAF_26560356_Chip-Seq_TH2_Human1.51115173
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.50437857
51CIITA_25753668_ChIP-Seq_RAJI_Human1.49342281
52* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48104856
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47772166
54RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47120158
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41919489
56* SPI1_23127762_ChIP-Seq_K562_Human1.39546214
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38940456
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38346616
59* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38324760
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36566424
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34321740
62PU_27001747_Chip-Seq_BMDM_Mouse1.32441773
63PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32065013
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30902116
65KDM2B_26808549_Chip-Seq_DND41_Human1.29391002
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.27911342
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24359427
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21376151
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21151866
70VDR_23849224_ChIP-Seq_CD4+_Human1.19945466
71GATA1_22025678_ChIP-Seq_K562_Human1.16937191
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15833604
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12988022
74* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12687374
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11675492
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09040331
77FOXP3_21729870_ChIP-Seq_TREG_Human1.08946959
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06368697
79ELK1_19687146_ChIP-ChIP_HELA_Human1.03451353
80LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03225279
81* GATA3_26560356_Chip-Seq_TH2_Human1.01276285
82RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00857430
83* TFEB_21752829_ChIP-Seq_HELA_Human1.00037902
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99511091
85Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99443034
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.98637725
87* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97844800
88GATA1_19941826_ChIP-Seq_K562_Human0.96585483
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95298309
90SMRT_27268052_Chip-Seq_Bcells_Human0.94403415
91GATA2_19941826_ChIP-Seq_K562_Human0.93489478
92* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91723911
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91616053
94GATA2_21666600_ChIP-Seq_HMVEC_Human0.91420894
95NCOR1_26117541_ChIP-Seq_K562_Human0.90707276
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.90512445
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90008661
98MYC_18555785_ChIP-Seq_MESCs_Mouse0.89118912
99GATA3_26560356_Chip-Seq_TH1_Human0.88577021
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88125662
101* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87856284
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.85052986
103KDM5A_27292631_Chip-Seq_BREAST_Human0.84538538
104PU.1_20513432_ChIP-Seq_Bcells_Mouse0.83433502
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.82019974
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80527178
107MYC_19079543_ChIP-ChIP_MESCs_Mouse0.79666206
108GATA1_19941827_ChIP-Seq_MEL_Mouse0.79115957
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79109354
110XRN2_22483619_ChIP-Seq_HELA_Human0.78154808
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.77310471
112VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75429384
113ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75087693
114* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74990734
115* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.74967847
116GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74808486
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.74375674
118* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73701462
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.72748113
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71913020
121KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.71584317
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.71102768

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.99192087
2MP0000685_abnormal_immune_system3.36975080
3MP0005671_abnormal_response_to3.32131826
4MP0003763_abnormal_thymus_physiology3.27631574
5MP0001800_abnormal_humoral_immune3.11791627
6MP0001790_abnormal_immune_system2.96249618
7MP0005387_immune_system_phenotype2.96249618
8MP0002166_altered_tumor_susceptibility2.84088501
9MP0005000_abnormal_immune_tolerance2.70853493
10* MP0002452_abnormal_antigen_presenting2.68651281
11MP0002396_abnormal_hematopoietic_system2.66589861
12MP0009785_altered_susceptibility_to2.66405259
13MP0003436_decreased_susceptibility_to2.65723798
14* MP0002398_abnormal_bone_marrow2.59640339
15* MP0002420_abnormal_adaptive_immunity2.58980704
16* MP0002723_abnormal_immune_serum2.58028540
17* MP0001819_abnormal_immune_cell2.57382108
18MP0002006_tumorigenesis2.37367263
19MP0005025_abnormal_response_to2.36213345
20MP0002148_abnormal_hypersensitivity_rea2.29762807
21* MP0000716_abnormal_immune_system2.27810200
22MP0003303_peritoneal_inflammation2.24908712
23MP0002419_abnormal_innate_immunity2.14192975
24MP0004808_abnormal_hematopoietic_stem2.12264365
25MP0004381_abnormal_hair_follicle2.10920330
26* MP0000689_abnormal_spleen_morphology2.08980382
27* MP0002722_abnormal_immune_system2.08321200
28MP0002405_respiratory_system_inflammati2.06638886
29* MP0000703_abnormal_thymus_morphology2.04743009
30MP0003300_gastrointestinal_ulcer1.99044283
31* MP0002429_abnormal_blood_cell1.92408401
32MP0009333_abnormal_splenocyte_physiolog1.92231909
33MP0008057_abnormal_DNA_replication1.91133582
34MP0010155_abnormal_intestine_physiology1.90897430
35MP0005464_abnormal_platelet_physiology1.86587570
36MP0002138_abnormal_hepatobiliary_system1.82789144
37MP0004947_skin_inflammation1.82481645
38MP0001873_stomach_inflammation1.79449256
39MP0006082_CNS_inflammation1.77234755
40MP0008260_abnormal_autophagy1.76851067
41MP0001545_abnormal_hematopoietic_system1.75208017
42MP0005397_hematopoietic_system_phenotyp1.75208017
43MP0010352_gastrointestinal_tract_polyps1.73960043
44MP0009278_abnormal_bone_marrow1.66925568
45MP0001853_heart_inflammation1.65975092
46MP0004510_myositis1.65673619
47MP0010094_abnormal_chromosome_stability1.63321840
48MP0001845_abnormal_inflammatory_respons1.58212932
49MP0005451_abnormal_body_composition1.53707302
50MP0003693_abnormal_embryo_hatching1.46805444
51MP0005310_abnormal_salivary_gland1.46585322
52MP0003077_abnormal_cell_cycle1.44200717
53MP0005076_abnormal_cell_differentiation1.43938951
54MP0000490_abnormal_crypts_of1.40033455
55MP0010307_abnormal_tumor_latency1.39894035
56MP0003828_pulmonary_edema1.38277402
57MP0002009_preneoplasia1.37527730
58MP0003724_increased_susceptibility_to1.33436795
59MP0000569_abnormal_digit_pigmentation1.33010154
60MP0003866_abnormal_defecation1.32868635
61MP0000858_altered_metastatic_potential1.32860398
62MP0004883_abnormal_blood_vessel1.30158569
63MP0003448_altered_tumor_morphology1.25410371
64MP0005174_abnormal_tail_pigmentation1.24869114
65* MP0002019_abnormal_tumor_incidence1.22890775
66MP0000465_gastrointestinal_hemorrhage1.22095953
67MP0001348_abnormal_lacrimal_gland1.20557996
68MP0003656_abnormal_erythrocyte_physiolo1.19612998
69MP0003111_abnormal_nucleus_morphology1.18790386
70MP0001533_abnormal_skeleton_physiology1.09822735
71MP0002933_joint_inflammation1.09731559
72MP0002877_abnormal_melanocyte_morpholog1.06319421
73MP0008469_abnormal_protein_level1.03141281
74MP0008007_abnormal_cellular_replicative1.02659660
75MP0004957_abnormal_blastocyst_morpholog0.94017557
76MP0005075_abnormal_melanosome_morpholog0.90945138
77MP0008058_abnormal_DNA_repair0.90671534
78MP0003787_abnormal_imprinting0.89647324
79MP0002132_abnormal_respiratory_system0.88922552
80MP0000350_abnormal_cell_proliferation0.88331551
81MP0003045_fibrosis0.86376511
82MP0005164_abnormal_response_to0.83482206
83MP0006054_spinal_hemorrhage0.81960791
84MP0000313_abnormal_cell_death0.80259194
85MP0002095_abnormal_skin_pigmentation0.79594655
86MP0003221_abnormal_cardiomyocyte_apopto0.78858522
87MP0003566_abnormal_cell_adhesion0.78572270
88MP0008877_abnormal_DNA_methylation0.76782769
89MP0003091_abnormal_cell_migration0.73673228
90MP0001851_eye_inflammation0.71961811
91MP0009764_decreased_sensitivity_to0.70653319
92MP0000015_abnormal_ear_pigmentation0.70322037
93MP0002998_abnormal_bone_remodeling0.69052665
94MP0002163_abnormal_gland_morphology0.67915049
95MP0001663_abnormal_digestive_system0.67387069
96MP0003172_abnormal_lysosome_physiology0.66836374
97MP0000371_diluted_coat_color0.66791675
98MP0003453_abnormal_keratinocyte_physiol0.66251689
99MP0009765_abnormal_xenobiotic_induced0.64379366
100MP0005058_abnormal_lysosome_morphology0.63390751
101MP0003943_abnormal_hepatobiliary_system0.63280733
102MP0005621_abnormal_cell_physiology0.61830286
103MP0009763_increased_sensitivity_to0.61325433
104MP0003183_abnormal_peptide_metabolism0.61308281
105MP0005023_abnormal_wound_healing0.61206495
106MP0004130_abnormal_muscle_cell0.60469971
107MP0002277_abnormal_respiratory_mucosa0.57682455
108MP0003690_abnormal_glial_cell0.57649005
109MP0001730_embryonic_growth_arrest0.57316664
110MP0003191_abnormal_cellular_cholesterol0.56177227
111MP0005166_decreased_susceptibility_to0.55717457
112MP0000604_amyloidosis0.55612107
113MP0001915_intracranial_hemorrhage0.54732968
114MP0008961_abnormal_basal_metabolism0.54017934
115MP0008004_abnormal_stomach_pH0.53887231
116MP0000249_abnormal_blood_vessel0.52138211
117MP0004484_altered_response_of0.51704356
118MP0000477_abnormal_intestine_morphology0.51577852
119MP0009115_abnormal_fat_cell0.51356417
120MP0000343_altered_response_to0.50420252
121MP0003795_abnormal_bone_structure0.49690023
122MP0002693_abnormal_pancreas_physiology0.49422337
123MP0000609_abnormal_liver_physiology0.46860437
124MP0002928_abnormal_bile_duct0.45255652
125MP0005376_homeostasis/metabolism_phenot0.44527073

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)5.01841171
2T lymphocytopenia (HP:0005403)4.99801880
3* Recurrent viral infections (HP:0004429)4.57619947
4Panhypogammaglobulinemia (HP:0003139)4.37494595
5Agammaglobulinemia (HP:0004432)4.35364979
6* Recurrent fungal infections (HP:0002841)4.17670479
7Eczematoid dermatitis (HP:0000976)4.11381703
8Recurrent bronchitis (HP:0002837)4.11228841
9Abnormal delayed hypersensitivity skin test (HP:0002963)4.10480777
10Recurrent abscess formation (HP:0002722)4.07785945
11Thyroiditis (HP:0100646)4.06229349
12Abnormality of T cells (HP:0002843)4.05042122
13Chronic otitis media (HP:0000389)3.97861121
14IgM deficiency (HP:0002850)3.80470391
15Severe combined immunodeficiency (HP:0004430)3.76913105
16Recurrent bacterial skin infections (HP:0005406)3.76121491
17Cellulitis (HP:0100658)3.73060861
18B lymphocytopenia (HP:0010976)3.70147647
19Abnormality of B cell number (HP:0010975)3.70147647
20Combined immunodeficiency (HP:0005387)3.61690728
21Meningitis (HP:0001287)3.61053295
22Elevated erythrocyte sedimentation rate (HP:0003565)3.58952097
23Myositis (HP:0100614)3.54364904
24Autoimmune thrombocytopenia (HP:0001973)3.50855372
25Abnormality of the fingertips (HP:0001211)3.46923074
26Chronic mucocutaneous candidiasis (HP:0002728)3.46382566
27Recurrent cutaneous fungal infections (HP:0011370)3.46382566
28Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.43702435
29Eosinophilia (HP:0001880)3.38744991
30IgG deficiency (HP:0004315)3.33824439
31Mediastinal lymphadenopathy (HP:0100721)3.29154917
32Thrombocytosis (HP:0001894)3.24837347
33Abnormality of eosinophils (HP:0001879)3.22460777
34Abnormality of T cell physiology (HP:0011840)3.17191037
35Vasculitis (HP:0002633)3.13231416
36Leukocytosis (HP:0001974)3.08944605
37Inflammation of the large intestine (HP:0002037)3.05556650
38Gastrointestinal inflammation (HP:0004386)3.01355091
39Granulocytopenia (HP:0001913)3.00228605
40Nasal polyposis (HP:0100582)2.99071104
41Recurrent skin infections (HP:0001581)2.97897705
42Colitis (HP:0002583)2.93803702
43Retrobulbar optic neuritis (HP:0100654)2.86644673
44Optic neuritis (HP:0100653)2.86644673
45Stomatitis (HP:0010280)2.82059496
46* Papilloma (HP:0012740)2.77758190
47* Verrucae (HP:0200043)2.77758190
48Orchitis (HP:0100796)2.73122089
49Spontaneous hematomas (HP:0007420)2.69731729
50Pustule (HP:0200039)2.68812313
51Obstructive lung disease (HP:0006536)2.68428752
52Chronic obstructive pulmonary disease (HP:0006510)2.68428752
53Urticaria (HP:0001025)2.65234797
54Osteomyelitis (HP:0002754)2.65072240
55IgA deficiency (HP:0002720)2.64460031
56Chronic sinusitis (HP:0011109)2.61918497
57* Abnormality of cells of the lymphoid lineage (HP:0012140)2.59897876
58Hypoplasia of the thymus (HP:0000778)2.58567560
59Lymphoma (HP:0002665)2.57121189
60Abnormality of the nasal mucosa (HP:0000433)2.56438569
61* Lymphopenia (HP:0001888)2.55737227
62Encephalitis (HP:0002383)2.52587806
63Arterial thrombosis (HP:0004420)2.47526491
64Pulmonary infiltrates (HP:0002113)2.45689581
65Chronic diarrhea (HP:0002028)2.45240857
66Autoimmune hemolytic anemia (HP:0001890)2.44228981
67Recurrent sinusitis (HP:0011108)2.43812136
68Recurrent gram-negative bacterial infections (HP:0005420)2.41179131
69Gastrointestinal stroma tumor (HP:0100723)2.40875659
70Pulmonary embolism (HP:0002204)2.40650144
71Periodontitis (HP:0000704)2.39796200
72Slow saccadic eye movements (HP:0000514)2.38617365
73Abnormality of macrophages (HP:0004311)2.36773542
74Anorexia (HP:0002039)2.34483568
75Subacute progressive viral hepatitis (HP:0006572)2.32700954
76Gangrene (HP:0100758)2.31701597
77Increased IgE level (HP:0003212)2.30912086
78Amaurosis fugax (HP:0100576)2.30684859
79Acute hepatic failure (HP:0006554)2.29861504
80Gastrointestinal infarctions (HP:0005244)2.28988564
81Increased IgM level (HP:0003496)2.27296603
82Hypochromic anemia (HP:0001931)2.26186728
83Sepsis (HP:0100806)2.25576780
84Petechiae (HP:0000967)2.23279363
85Prolonged bleeding time (HP:0003010)2.22761608
86Bronchitis (HP:0012387)2.21974658
87Chest pain (HP:0100749)2.20366629
88Joint swelling (HP:0001386)2.19142141
89Interstitial pulmonary disease (HP:0006530)2.17929464
90Acute myeloid leukemia (HP:0004808)2.16052670
91Keratoconjunctivitis sicca (HP:0001097)2.15630444
92Hemoptysis (HP:0002105)2.14721993
93Recurrent pneumonia (HP:0006532)2.14645051
94Volvulus (HP:0002580)2.14111691
95Abnormal platelet volume (HP:0011876)2.12447533
96Abnormality of the pleura (HP:0002103)2.11342056
97Hypergammaglobulinemia (HP:0010702)2.10829284
98Neoplasm of the tracheobronchial system (HP:0100552)2.10078321
99Skin ulcer (HP:0200042)2.04792272
100Gingivitis (HP:0000230)2.04648218
101Recurrent lower respiratory tract infections (HP:0002783)2.03836666
102Abnormality of the prostate (HP:0008775)2.02053789
103Hematochezia (HP:0002573)2.01850567
104Basal cell carcinoma (HP:0002671)2.00770479
105Stomach cancer (HP:0012126)1.99014362
106Gingival bleeding (HP:0000225)1.98949309
107Epistaxis (HP:0000421)1.98868772
108Keratoconjunctivitis (HP:0001096)1.96684353
109Papilledema (HP:0001085)1.96297446
110Viral hepatitis (HP:0006562)1.95670022
111Glomerulopathy (HP:0100820)1.94873870
112Fatigue (HP:0012378)1.93265902
113Emphysema (HP:0002097)1.92486035
114Hypochromic microcytic anemia (HP:0004840)1.91436985
115Alveolar cell carcinoma (HP:0006519)1.90031835
116Keratitis (HP:0000491)1.88740136
117Prominent nose (HP:0000448)1.88228691
118Myelodysplasia (HP:0002863)1.84710141

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.63229489
2TXK3.23377004
3MAP3K142.85023427
4JAK32.84122174
5MAP3K102.81065762
6STK102.60660961
7TYK22.53294689
8EEF2K2.30764092
9GRK62.28026629
10ZAP702.13830788
11ITK2.04520485
12IKBKE2.03880393
13PRPF4B1.99464216
14BTK1.98749832
15CDK121.89585505
16IRAK41.88621765
17TBK11.86672701
18BLK1.84129967
19SYK1.84070703
20JAK11.81368693
21IKBKB1.71738595
22TEC1.70624708
23KIT1.64934397
24FGFR31.59131725
25BMPR21.52329305
26MAP3K131.51836622
27FGFR41.50888356
28PKN21.50494826
29MST41.49693211
30FGR1.48921535
31PIM11.48040671
32LRRK21.46711627
33PIK3CG1.44826886
34CSF1R1.44654101
35LCK1.43362634
36CAMKK21.41980693
37CHUK1.41644053
38RPS6KA41.37141491
39HCK1.37070476
40CSK1.33863533
41NLK1.32916390
42IRAK11.25711433
43FLT31.24898229
44RIPK41.22277440
45CLK11.22068038
46NEK21.20691638
47CDK41.16885098
48CDC71.13183775
49NEK91.07071689
50CDK60.98768100
51FRK0.98237018
52SIK20.94966699
53LYN0.93756533
54SGK20.93615289
55EPHB10.93440009
56MARK30.92381539
57MAP3K10.90945928
58STK240.90070230
59YES10.89503809
60MAP3K30.84382678
61IRAK20.84337093
62TRIB30.83458065
63WNK10.83137819
64RPS6KB20.83030734
65JAK20.81740171
66SGK30.81323910
67MAP2K30.80384895
68TGFBR10.80367524
69TAOK30.79204064
70BRD40.79010081
71PRKCQ0.77295779
72MAP3K20.77177603
73ERN10.76306662
74ATR0.75365115
75ACVR1B0.74662999
76MAP3K80.74589745
77FES0.72866340
78STK30.72622535
79CDK90.72319708
80ALK0.71037246
81MARK20.66043389
82TGFBR20.64908900
83IRAK30.64534652
84PTK2B0.63716019
85CAMKK10.63677141
86PTK60.63209202
87PASK0.58800703
88KSR20.57761230
89MELK0.57264828
90TESK20.56021308
91TRPM70.55973598
92SIK30.52307446
93* STK40.51806889
94TAOK10.51382973
95MAPKAPK20.50526769
96HIPK20.49698231
97TLK10.48097332
98PIM20.47537321
99MAPK120.47474254
100MAP3K50.47242107
101RPS6KA50.45015119
102NUAK10.44511593
103SMG10.42850391
104RAF10.42614382
105FYN0.42541755
106RPS6KA60.40400685
107TNK20.40148941
108TTN0.39687866
109STK110.39168357
110MAPK70.38848495
111KSR10.38727296
112MAP3K110.38381658
113* CHEK10.38230549
114PDGFRB0.38125074
115MAPK110.36652227
116GRK50.36475195
117RET0.36130790
118AURKB0.34960737
119NEK60.34932596
120ATM0.34648619
121ABL10.34542931
122EGFR0.33686601
123DYRK30.33169928
124SGK2230.32962538
125SGK4940.32962538
126EPHA30.31139760
127MAP3K70.30256318
128TSSK60.30099521
129PDK10.29876811
130CDK70.29442259
131MATK0.29094261
132NME20.28450692
133RPS6KC10.28407483
134RPS6KL10.28407483
135MAPK30.28037509

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.12968703
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.64357621
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.48139241
4B cell receptor signaling pathway_Homo sapiens_hsa046622.45604173
5Leishmaniasis_Homo sapiens_hsa051402.34574971
6Measles_Homo sapiens_hsa051622.34245265
7Antigen processing and presentation_Homo sapiens_hsa046122.34161581
8T cell receptor signaling pathway_Homo sapiens_hsa046602.17842418
9Allograft rejection_Homo sapiens_hsa053302.14854984
10Osteoclast differentiation_Homo sapiens_hsa043802.04191771
11Graft-versus-host disease_Homo sapiens_hsa053322.03329056
12Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.01842642
13Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97831626
14Herpes simplex infection_Homo sapiens_hsa051681.79594672
15Hematopoietic cell lineage_Homo sapiens_hsa046401.79415635
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70703009
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66274121
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61501413
19DNA replication_Homo sapiens_hsa030301.59684296
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.57721002
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57105124
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56406281
23Toxoplasmosis_Homo sapiens_hsa051451.52130792
24Non-homologous end-joining_Homo sapiens_hsa034501.45658933
25Influenza A_Homo sapiens_hsa051641.42386646
26Viral myocarditis_Homo sapiens_hsa054161.41086443
27Acute myeloid leukemia_Homo sapiens_hsa052211.41005370
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38885242
29Apoptosis_Homo sapiens_hsa042101.38681630
30Hepatitis B_Homo sapiens_hsa051611.37985109
31Chemokine signaling pathway_Homo sapiens_hsa040621.37918802
32Legionellosis_Homo sapiens_hsa051341.34343198
33TNF signaling pathway_Homo sapiens_hsa046681.33166496
34Chronic myeloid leukemia_Homo sapiens_hsa052201.32349331
35Base excision repair_Homo sapiens_hsa034101.30351860
36Autoimmune thyroid disease_Homo sapiens_hsa053201.29781107
37Mismatch repair_Homo sapiens_hsa034301.26181626
38Viral carcinogenesis_Homo sapiens_hsa052031.25382178
39Shigellosis_Homo sapiens_hsa051311.23476214
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.22949913
41Epstein-Barr virus infection_Homo sapiens_hsa051691.22011647
42Tuberculosis_Homo sapiens_hsa051521.19657455
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17300441
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15938048
45Pancreatic cancer_Homo sapiens_hsa052121.09642371
46Asthma_Homo sapiens_hsa053101.08163418
47HTLV-I infection_Homo sapiens_hsa051661.04548701
48Small cell lung cancer_Homo sapiens_hsa052220.99761070
49Pertussis_Homo sapiens_hsa051330.98842283
50p53 signaling pathway_Homo sapiens_hsa041150.98119096
51Spliceosome_Homo sapiens_hsa030400.97024616
52Cell cycle_Homo sapiens_hsa041100.96851469
53Platelet activation_Homo sapiens_hsa046110.95169747
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93572849
55Homologous recombination_Homo sapiens_hsa034400.91008374
56Type I diabetes mellitus_Homo sapiens_hsa049400.91003306
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89754662
58Malaria_Homo sapiens_hsa051440.85881036
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.85745921
60Dorso-ventral axis formation_Homo sapiens_hsa043200.84686459
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84486032
62Systemic lupus erythematosus_Homo sapiens_hsa053220.84161624
63Hepatitis C_Homo sapiens_hsa051600.83961739
64Staphylococcus aureus infection_Homo sapiens_hsa051500.80386040
65Prolactin signaling pathway_Homo sapiens_hsa049170.79426910
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.79077407
67Colorectal cancer_Homo sapiens_hsa052100.78536148
68Salmonella infection_Homo sapiens_hsa051320.78121921
69One carbon pool by folate_Homo sapiens_hsa006700.72518605
70* Non-small cell lung cancer_Homo sapiens_hsa052230.72063134
71Phagosome_Homo sapiens_hsa041450.71444332
72Fanconi anemia pathway_Homo sapiens_hsa034600.70941582
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.70818268
74MicroRNAs in cancer_Homo sapiens_hsa052060.69212506
75RNA transport_Homo sapiens_hsa030130.68354002
76Ribosome_Homo sapiens_hsa030100.66284933
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64779427
78mRNA surveillance pathway_Homo sapiens_hsa030150.61432378
79Nucleotide excision repair_Homo sapiens_hsa034200.61080777
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.60949415
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60804661
82RNA degradation_Homo sapiens_hsa030180.58026385
83VEGF signaling pathway_Homo sapiens_hsa043700.56516837
84Notch signaling pathway_Homo sapiens_hsa043300.56469463
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55965505
86Choline metabolism in cancer_Homo sapiens_hsa052310.53203232
87Prostate cancer_Homo sapiens_hsa052150.53027521
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52898891
89* FoxO signaling pathway_Homo sapiens_hsa040680.52698898
90Thyroid cancer_Homo sapiens_hsa052160.52543221
91Glioma_Homo sapiens_hsa052140.52379511
92African trypanosomiasis_Homo sapiens_hsa051430.51653664
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49849917
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49297163
95mTOR signaling pathway_Homo sapiens_hsa041500.49162373
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47607885
97ErbB signaling pathway_Homo sapiens_hsa040120.46655839
98HIF-1 signaling pathway_Homo sapiens_hsa040660.45362746
99Endometrial cancer_Homo sapiens_hsa052130.44919362
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44247799
101* MAPK signaling pathway_Homo sapiens_hsa040100.43718316
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.43489830
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43203889
104Rheumatoid arthritis_Homo sapiens_hsa053230.41905583
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.41413687
106Inositol phosphate metabolism_Homo sapiens_hsa005620.40414131
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37398985
108GnRH signaling pathway_Homo sapiens_hsa049120.36452857
109Insulin resistance_Homo sapiens_hsa049310.35564669
110Proteoglycans in cancer_Homo sapiens_hsa052050.35408928
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35008835
112* Pathways in cancer_Homo sapiens_hsa052000.33594490
113Endocytosis_Homo sapiens_hsa041440.33577133
114Type II diabetes mellitus_Homo sapiens_hsa049300.33259649
115Other glycan degradation_Homo sapiens_hsa005110.33168064
116Regulation of autophagy_Homo sapiens_hsa041400.32080420
117Adherens junction_Homo sapiens_hsa045200.31363326
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31290504
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30246958
120Renal cell carcinoma_Homo sapiens_hsa052110.29684192
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29493171
122Long-term potentiation_Homo sapiens_hsa047200.28599445

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