STK40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.12381836
2modulation by symbiont of host defense response (GO:0052031)5.12381836
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.12381836
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.12381836
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.12381836
6modulation by symbiont of host immune response (GO:0052553)5.12381836
7negative regulation of cell killing (GO:0031342)5.11158181
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.11158181
9positive regulation of gamma-delta T cell activation (GO:0046645)4.97363970
10neutrophil activation involved in immune response (GO:0002283)4.93659131
11response to peptidoglycan (GO:0032494)4.79476734
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.76349579
13macrophage activation involved in immune response (GO:0002281)4.48082431
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.38872237
15negative regulation of erythrocyte differentiation (GO:0045647)4.35573362
16detection of other organism (GO:0098543)4.33733776
17negative regulation of interleukin-12 production (GO:0032695)4.28120650
18low-density lipoprotein particle clearance (GO:0034383)4.19374473
19antigen processing and presentation of endogenous antigen (GO:0019883)4.15247056
20detection of bacterium (GO:0016045)4.13330624
21regulation of cholesterol homeostasis (GO:2000188)3.96386905
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.95627612
23carnitine shuttle (GO:0006853)3.95376283
24detection of molecule of bacterial origin (GO:0032490)3.86181811
25fatty acid transmembrane transport (GO:1902001)3.85386781
26germinal center formation (GO:0002467)3.83504133
27detection of external biotic stimulus (GO:0098581)3.81558040
28positive regulation of fatty acid beta-oxidation (GO:0032000)3.81168294
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.70140270
30regulation of mast cell degranulation (GO:0043304)3.66739657
31regulation of gamma-delta T cell activation (GO:0046643)3.64999153
32regulation of interferon-beta biosynthetic process (GO:0045357)3.64154090
33lysine catabolic process (GO:0006554)3.61898158
34lysine metabolic process (GO:0006553)3.61898158
35cellular extravasation (GO:0045123)3.59612711
36lipopolysaccharide-mediated signaling pathway (GO:0031663)3.58411129
37neutrophil activation (GO:0042119)3.57160305
38regulation of B cell receptor signaling pathway (GO:0050855)3.55315125
39granulocyte activation (GO:0036230)3.54715126
402-oxoglutarate metabolic process (GO:0006103)3.52605641
41regulation of fatty acid beta-oxidation (GO:0031998)3.50683752
42immunoglobulin mediated immune response (GO:0016064)3.47619087
43response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.46302391
44response to host immune response (GO:0052572)3.46302391
45leukocyte aggregation (GO:0070486)3.42399519
46positive regulation of lipid storage (GO:0010884)3.41493508
47positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.39570517
48regulation of sequestering of triglyceride (GO:0010889)3.37615372
49regulation of T-helper 2 cell differentiation (GO:0045628)3.37557493
50response to muramyl dipeptide (GO:0032495)3.35432593
51sarcomere organization (GO:0045214)3.34501179
52detection of biotic stimulus (GO:0009595)3.33792430
53regulation of cholesterol storage (GO:0010885)3.32604880
54positive regulation of histone deacetylation (GO:0031065)3.30836950
55regulation of leukocyte degranulation (GO:0043300)3.30276805
56regulation of mast cell activation involved in immune response (GO:0033006)3.29326099
57positive regulation of p38MAPK cascade (GO:1900745)3.27326286
58regulation of p38MAPK cascade (GO:1900744)3.27255231
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26462285
60response to host (GO:0075136)3.26462285
61response to host defenses (GO:0052200)3.26462285
62positive regulation of fatty acid oxidation (GO:0046321)3.25896755
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.25872844
64regulation of myeloid leukocyte mediated immunity (GO:0002886)3.25700488
65regulation of fatty acid oxidation (GO:0046320)3.24052232
66macrophage activation (GO:0042116)3.20144232
67myeloid cell activation involved in immune response (GO:0002275)3.17178419
68carnitine transmembrane transport (GO:1902603)3.16742731
69plasma membrane repair (GO:0001778)3.15646403
70valine metabolic process (GO:0006573)3.12496653
71amino-acid betaine transport (GO:0015838)3.10944279
72carnitine transport (GO:0015879)3.10944279
73negative regulation of cytokine production involved in immune response (GO:0002719)3.08243366
74alpha-linolenic acid metabolic process (GO:0036109)3.07388970
75negative regulation of fatty acid biosynthetic process (GO:0045717)3.06826579
76respiratory burst (GO:0045730)3.06769028
77negative regulation of leukocyte mediated immunity (GO:0002704)3.06539610
78cellular response to type I interferon (GO:0071357)3.05081794
79type I interferon signaling pathway (GO:0060337)3.05081794
80leukocyte migration involved in inflammatory response (GO:0002523)3.04873942
81NIK/NF-kappaB signaling (GO:0038061)3.04098016
82positive regulation of mast cell activation (GO:0033005)3.03149919
83response to type I interferon (GO:0034340)3.02342802
84negative regulation of cell size (GO:0045792)2.98713818
854-hydroxyproline metabolic process (GO:0019471)2.98103943
86regulation of triglyceride catabolic process (GO:0010896)2.95085543
87growth hormone receptor signaling pathway (GO:0060396)2.94353637
88bundle of His cell to Purkinje myocyte communication (GO:0086069)2.94091482
89positive regulation of lipid catabolic process (GO:0050996)2.93939031
90positive regulation of cellular amide metabolic process (GO:0034250)2.93270848
91defense response to protozoan (GO:0042832)2.89255074
92plasma lipoprotein particle clearance (GO:0034381)2.88683498
93microglial cell activation (GO:0001774)2.88216760
94fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.88178256
95response to interleukin-15 (GO:0070672)2.87753745
96positive regulation of triglyceride metabolic process (GO:0090208)2.87710491
97fatty acid beta-oxidation (GO:0006635)2.87395700
98positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.85241266
99positive regulation of triglyceride biosynthetic process (GO:0010867)2.85128748
100kynurenine metabolic process (GO:0070189)2.82082515
101regulation of mast cell activation (GO:0033003)2.81743498
102tricarboxylic acid metabolic process (GO:0072350)2.81344615
103negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81305222
104neutrophil mediated immunity (GO:0002446)2.80484343
105B cell receptor signaling pathway (GO:0050853)2.79002520
106tolerance induction (GO:0002507)2.78579876
107protein carboxylation (GO:0018214)2.78379385
108peptidyl-glutamic acid carboxylation (GO:0017187)2.78379385
109homocysteine metabolic process (GO:0050667)2.77612331
110actin-myosin filament sliding (GO:0033275)2.77607713
111muscle filament sliding (GO:0030049)2.77607713
112negative regulation of toll-like receptor signaling pathway (GO:0034122)2.76864424
113cysteine metabolic process (GO:0006534)2.76381159
114negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.75552235
115interferon-gamma-mediated signaling pathway (GO:0060333)2.75540046
116positive thymic T cell selection (GO:0045059)2.75306347
117cardiac myofibril assembly (GO:0055003)2.74595415
118acetyl-CoA metabolic process (GO:0006084)2.74211025
119negative regulation of T cell mediated immunity (GO:0002710)2.73886083
120regulation of T cell tolerance induction (GO:0002664)2.73545760
121production of molecular mediator involved in inflammatory response (GO:0002532)2.72951664
122response to protozoan (GO:0001562)2.72569201
123cell-substrate junction assembly (GO:0007044)2.71435721
124T-helper 1 type immune response (GO:0042088)2.71198149
125positive regulation of B cell differentiation (GO:0045579)2.70817556
126positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.70808359
127negative regulation of fibrinolysis (GO:0051918)2.70666558
128regulation of tolerance induction (GO:0002643)2.70626850
129regulation of regulated secretory pathway (GO:1903305)2.70393107
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.69644980
131positive regulation of mast cell activation involved in immune response (GO:0033008)2.69438974
132positive regulation of mast cell degranulation (GO:0043306)2.69438974
133amino-acid betaine metabolic process (GO:0006577)2.68650012
134triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.67995946
135regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.66612165
136myeloid dendritic cell differentiation (GO:0043011)2.66599742
137negative regulation of interleukin-6 production (GO:0032715)2.65494105
138negative regulation of lipid transport (GO:0032369)2.65362783
139regulation of triglyceride biosynthetic process (GO:0010866)2.64699514
140regulation of necroptotic process (GO:0060544)2.64287666
141modulation by symbiont of host cellular process (GO:0044068)2.63600287
142serine family amino acid catabolic process (GO:0009071)2.63567827
143desmosome organization (GO:0002934)2.62514112
144complement activation, alternative pathway (GO:0006957)2.62285972
145regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.61902029
146positive regulation of type 2 immune response (GO:0002830)2.60776088
147oxaloacetate metabolic process (GO:0006107)2.60614747
148fatty acid oxidation (GO:0019395)2.60614268
149B cell mediated immunity (GO:0019724)2.60152936
150myofibril assembly (GO:0030239)2.59974285
151creatine metabolic process (GO:0006600)2.59589385
152protein localization to endosome (GO:0036010)2.58611122
153aspartate family amino acid catabolic process (GO:0009068)2.58028666
154negative regulation of cholesterol transport (GO:0032375)2.57966695
155negative regulation of sterol transport (GO:0032372)2.57966695
156positive regulation of glycogen biosynthetic process (GO:0045725)2.57580646
157leukocyte degranulation (GO:0043299)2.57522152
158sulfur amino acid catabolic process (GO:0000098)2.57314743
159negative regulation of innate immune response (GO:0045824)2.57208965
160positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.56993951
161regulation of fatty acid biosynthetic process (GO:0042304)2.56989155
162negative regulation of fatty acid transport (GO:2000192)2.55915570
163negative regulation of type 2 immune response (GO:0002829)2.55361135
164carnitine metabolic process (GO:0009437)2.55033799
165antigen processing and presentation via MHC class Ib (GO:0002475)2.54747722
166lipid oxidation (GO:0034440)2.54597353
167regulation of type 2 immune response (GO:0002828)2.53961509
168phospholipid homeostasis (GO:0055091)2.52938917
169regulation of interleukin-12 biosynthetic process (GO:0045075)2.52235902
170cell-substrate adherens junction assembly (GO:0007045)2.51979587
171focal adhesion assembly (GO:0048041)2.51979587
1723-UTR-mediated mRNA stabilization (GO:0070935)2.51671077
173negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.51598909
174skeletal muscle adaptation (GO:0043501)2.50254250
175JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.49564751
176negative regulation of fatty acid metabolic process (GO:0045922)2.49229726
177apoptotic cell clearance (GO:0043277)2.48615151
178urea metabolic process (GO:0019627)2.48506306
179urea cycle (GO:0000050)2.48506306
180cellular response to growth hormone stimulus (GO:0071378)2.45404022
181regulation of triglyceride metabolic process (GO:0090207)2.45095240
182epithelial cell-cell adhesion (GO:0090136)2.44597115
183negative regulation of potassium ion transmembrane transport (GO:1901380)2.43240729
184negative regulation of heart growth (GO:0061117)2.41875840
185negative regulation of cardiac muscle tissue growth (GO:0055022)2.41875840
186biotin metabolic process (GO:0006768)2.40866931
187regulation of gamma-delta T cell differentiation (GO:0045586)2.40809111
188regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38872615
189dicarboxylic acid biosynthetic process (GO:0043650)2.38115271
190regulation of membrane protein ectodomain proteolysis (GO:0051043)2.37678726
191negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.37658550
192apoptotic process involved in morphogenesis (GO:0060561)2.37248529
193maternal placenta development (GO:0001893)2.36256720
194quaternary ammonium group transport (GO:0015697)2.36180990
195fatty acid catabolic process (GO:0009062)2.35327944
196fatty acid homeostasis (GO:0055089)2.35287797
197positive regulation of glycogen metabolic process (GO:0070875)2.33718076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.31723073
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.15482308
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.86631613
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42668299
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.34711284
6* RXR_22158963_ChIP-Seq_LIVER_Mouse3.31128306
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.93622957
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.89816686
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.74008936
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52257015
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.45959391
12ZNF263_19887448_ChIP-Seq_K562_Human2.38220234
13MYC_22102868_ChIP-Seq_BL_Human2.28592624
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28232680
15* SPI1_23127762_ChIP-Seq_K562_Human2.26006075
16CLOCK_20551151_ChIP-Seq_293T_Human2.24331521
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.23122028
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.20872735
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18450571
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.18126537
21SCL_19346495_ChIP-Seq_HPC-7_Human2.07704829
22* ELK3_25401928_ChIP-Seq_HUVEC_Human2.07082591
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.06994529
24* RUNX1_22412390_ChIP-Seq_EML_Mouse2.03520437
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02789772
26* TCF7_22412390_ChIP-Seq_EML_Mouse1.97082034
27* KDM2B_26808549_Chip-Seq_DND41_Human1.94726809
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93634648
29* SPI1_23547873_ChIP-Seq_NB4_Human1.91151927
30LXR_22292898_ChIP-Seq_THP-1_Human1.86539046
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85925419
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.85312874
33STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85262986
34* RACK7_27058665_Chip-Seq_MCF-7_Human1.80286535
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78733038
36RUNX_20019798_ChIP-Seq_JUKART_Human1.78170411
37STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.77784604
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.75797130
39* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.75642474
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74815859
41* ATF3_27146783_Chip-Seq_COLON_Human1.74228028
42VDR_21846776_ChIP-Seq_THP-1_Human1.73524788
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72693415
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.71546649
45* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70133044
46* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68514945
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.64522393
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61063634
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.61001151
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59521132
51* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58685085
52* MAF_26560356_Chip-Seq_TH1_Human1.58102331
53* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57937141
54HIF1A_21447827_ChIP-Seq_MCF-7_Human1.57419555
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55842333
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53704770
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50415802
58MYB_26560356_Chip-Seq_TH2_Human1.48098095
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.47961326
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46600392
61* TBX20_22328084_ChIP-Seq_HEART_Mouse1.45905434
62* TBX20_22080862_ChIP-Seq_HEART_Mouse1.45905434
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45445564
64MYB_26560356_Chip-Seq_TH1_Human1.43570745
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42032745
66* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41232967
67BRD4_27068464_Chip-Seq_AML-cells_Mouse1.39341589
68* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.38635621
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33702072
70* UTX_26944678_Chip-Seq_JUKART_Human1.33599852
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31518013
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31422921
73* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31047345
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.27529578
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26727580
76* KDM2B_26808549_Chip-Seq_K562_Human1.26300996
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25861590
78ESR1_21235772_ChIP-Seq_MCF-7_Human1.25817535
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25064729
80IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24651678
81VDR_24787735_ChIP-Seq_THP-1_Human1.24149451
82NCOR1_26117541_ChIP-Seq_K562_Human1.23925617
83GATA1_19941826_ChIP-Seq_K562_Human1.21843555
84* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20988220
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20946857
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.20936459
87* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20601731
88* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19898108
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19846302
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19759566
91* KDM2B_26808549_Chip-Seq_JURKAT_Human1.17528025
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.17044178
93* CREB1_26743006_Chip-Seq_LNCaP_Human1.16538079
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16433690
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15909829
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15140214
97* GATA6_25053715_ChIP-Seq_YYC3_Human1.14360771
98* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13960185
99PU_27001747_Chip-Seq_BMDM_Mouse1.13834906
100BCL6_27268052_Chip-Seq_Bcells_Human1.13693170
101* MAF_26560356_Chip-Seq_TH2_Human1.10810774
102* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10501213
103PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10307633
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10080206
105* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09936607
106P68_20966046_ChIP-Seq_HELA_Human1.09233290
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07885965
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07300440
109* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07017668
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06400472
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.06331388
112IRF8_22096565_ChIP-ChIP_GC-B_Human1.06021962
113MYB_21317192_ChIP-Seq_ERMYB_Mouse1.05384016
114* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05227741
115PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04856822
116* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04277647
117ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04140592
118EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03814972
119* GATA2_21666600_ChIP-Seq_HMVEC_Human1.03701729
120ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.02621398
121CTCF_21964334_Chip-Seq_Bcells_Human1.02348827
122BCOR_27268052_Chip-Seq_Bcells_Human1.01915420
123CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01422174
124* SA1_27219007_Chip-Seq_ERYTHROID_Human1.00273326
125VDR_24763502_ChIP-Seq_THP-1_Human1.00267310
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00245186
127* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98086932
128UBF1/2_26484160_Chip-Seq_HMECs_Human0.98082123
129* GATA3_27048872_Chip-Seq_THYMUS_Human0.98006522
130SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97784913
131* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96674642
132NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96080903
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95738387
134FOXM1_23109430_ChIP-Seq_U2OS_Human0.95669812
135* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95404751
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.94934100
137GATA1_22025678_ChIP-Seq_K562_Human0.94789949
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.94091043
139SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92973215
140SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.92735495
141TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92158984
142ELF1_20517297_ChIP-Seq_JURKAT_Human0.91403415
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90829925
144TP63_22573176_ChIP-Seq_HFKS_Human0.89929613
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89342909
146TRIM28_21343339_ChIP-Seq_HEK293_Human0.88042821
147GATA2_19941826_ChIP-Seq_K562_Human0.87709625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.96686381
2MP0003705_abnormal_hypodermis_morpholog3.64124250
3MP0003646_muscle_fatigue3.02618840
4MP0001835_abnormal_antigen_presentation2.85771081
5MP0002419_abnormal_innate_immunity2.74776547
6MP0002139_abnormal_hepatobiliary_system2.63311218
7MP0002837_dystrophic_cardiac_calcinosis2.54830473
8MP0005025_abnormal_response_to2.52956681
9MP0005000_abnormal_immune_tolerance2.52371663
10MP0005464_abnormal_platelet_physiology2.47501675
11MP0005360_urolithiasis2.46621019
12MP0009785_altered_susceptibility_to2.44681788
13MP0005058_abnormal_lysosome_morphology2.43695418
14MP0006082_CNS_inflammation2.40849505
15MP0009840_abnormal_foam_cell2.40313990
16MP0004185_abnormal_adipocyte_glucose2.39879191
17MP0002148_abnormal_hypersensitivity_rea2.30546010
18MP0001800_abnormal_humoral_immune2.27326855
19MP0003303_peritoneal_inflammation2.25517415
20MP0005671_abnormal_response_to2.19872895
21MP0003172_abnormal_lysosome_physiology2.19632177
22MP0002723_abnormal_immune_serum2.17485068
23MP0002452_abnormal_antigen_presenting2.12864098
24MP0004510_myositis2.11852361
25MP0005666_abnormal_adipose_tissue2.06278924
26MP0002420_abnormal_adaptive_immunity2.06213868
27MP0003300_gastrointestinal_ulcer2.04453983
28MP0001819_abnormal_immune_cell2.03840348
29MP0004130_abnormal_muscle_cell2.03683439
30MP0010352_gastrointestinal_tract_polyps1.99606769
31MP0005365_abnormal_bile_salt1.99565787
32MP0000750_abnormal_muscle_regeneration1.98876551
33MP0005076_abnormal_cell_differentiation1.97336014
34MP0003566_abnormal_cell_adhesion1.94438654
35MP0004084_abnormal_cardiac_muscle1.94095341
36MP0008260_abnormal_autophagy1.88565614
37MP0005670_abnormal_white_adipose1.87707569
38MP0005085_abnormal_gallbladder_physiolo1.87585526
39MP0004087_abnormal_muscle_fiber1.79590686
40MP0008961_abnormal_basal_metabolism1.77835835
41MP0000751_myopathy1.75350685
42MP0005083_abnormal_biliary_tract1.72517101
43MP0005397_hematopoietic_system_phenotyp1.63559527
44MP0001545_abnormal_hematopoietic_system1.63559527
45MP0003763_abnormal_thymus_physiology1.63430908
46MP0002398_abnormal_bone_marrow1.63209666
47MP0009333_abnormal_splenocyte_physiolog1.61509000
48MP0002132_abnormal_respiratory_system1.60537554
49MP0003075_altered_response_to1.59276314
50MP0004036_abnormal_muscle_relaxation1.57668020
51MP0001845_abnormal_inflammatory_respons1.57137774
52MP0005375_adipose_tissue_phenotype1.55806145
53MP0000716_abnormal_immune_system1.55522447
54MP0005330_cardiomyopathy1.55257739
55MP0003191_abnormal_cellular_cholesterol1.54075897
56MP0009764_decreased_sensitivity_to1.52920330
57MP0003252_abnormal_bile_duct1.48554461
58MP0010630_abnormal_cardiac_muscle1.47953853
59MP0003436_decreased_susceptibility_to1.45571979
60MP0002998_abnormal_bone_remodeling1.45340423
61MP0010329_abnormal_lipoprotein_level1.44201590
62MP0000609_abnormal_liver_physiology1.42334777
63MP0000749_muscle_degeneration1.40476234
64MP0000465_gastrointestinal_hemorrhage1.40116061
65MP0008469_abnormal_protein_level1.38810648
66MP0008004_abnormal_stomach_pH1.38116397
67MP0002796_impaired_skin_barrier1.37372456
68MP0003806_abnormal_nucleotide_metabolis1.34832602
69MP0009278_abnormal_bone_marrow1.33777209
70MP0002138_abnormal_hepatobiliary_system1.32303767
71MP0002106_abnormal_muscle_physiology1.31889728
72MP0002722_abnormal_immune_system1.30687416
73MP0003453_abnormal_keratinocyte_physiol1.30091181
74MP0002429_abnormal_blood_cell1.29567429
75MP0000689_abnormal_spleen_morphology1.29209841
76MP0002269_muscular_atrophy1.28877302
77MP0005451_abnormal_body_composition1.27976525
78MP0005310_abnormal_salivary_gland1.27856992
79MP0000733_abnormal_muscle_development1.24382529
80MP0004947_skin_inflammation1.23531587
81MP0000759_abnormal_skeletal_muscle1.23171084
82MP0003221_abnormal_cardiomyocyte_apopto1.21626767
83MP0003828_pulmonary_edema1.21154603
84MP0005023_abnormal_wound_healing1.20235399
85MP0002254_reproductive_system_inflammat1.17420238
86MP0005385_cardiovascular_system_phenoty1.13890693
87MP0001544_abnormal_cardiovascular_syste1.13890693
88MP0002971_abnormal_brown_adipose1.13716374
89MP0001851_eye_inflammation1.11326310
90MP0003866_abnormal_defecation1.09970874
91MP0005319_abnormal_enzyme/_coenzyme1.09260396
92MP0000703_abnormal_thymus_morphology1.08442304
93MP0005166_decreased_susceptibility_to1.07486786
94MP0008875_abnormal_xenobiotic_pharmacok1.07243384
95MP0000604_amyloidosis1.06164402
96MP0003690_abnormal_glial_cell1.05930080
97MP0008775_abnormal_heart_ventricle1.05835749
98MP0000747_muscle_weakness1.04052889
99MP0005275_abnormal_skin_tensile1.03945358
100MP0001853_heart_inflammation1.03876260
101MP0000343_altered_response_to1.02433499
102MP0002118_abnormal_lipid_homeostasis1.01961385
103MP0010234_abnormal_vibrissa_follicle1.00361793
104MP0005620_abnormal_muscle_contractility0.99831047
105MP0002972_abnormal_cardiac_muscle0.97133429
106MP0005369_muscle_phenotype0.96947810
107MP0003183_abnormal_peptide_metabolism0.96339485
108MP0002332_abnormal_exercise_endurance0.95865614
109MP0005164_abnormal_response_to0.95724168
110MP0002877_abnormal_melanocyte_morpholog0.94733747
111MP0004808_abnormal_hematopoietic_stem0.94556466
112MP0000003_abnormal_adipose_tissue0.93978199
113MP0004883_abnormal_blood_vessel0.93427178
114MP0004381_abnormal_hair_follicle0.93413193
115MP0005167_abnormal_blood-brain_barrier0.93111263
116MP0005332_abnormal_amino_acid0.92913629
117MP0004858_abnormal_nervous_system0.90849219
118MP0001663_abnormal_digestive_system0.90148425
119MP0010368_abnormal_lymphatic_system0.90028321
120MP0001666_abnormal_nutrient_absorption0.88949387
121MP0002396_abnormal_hematopoietic_system0.88914914
122MP0009643_abnormal_urine_homeostasis0.88009376
123MP0009763_increased_sensitivity_to0.87010974
124MP0004215_abnormal_myocardial_fiber0.86264354
125MP0002060_abnormal_skin_morphology0.85527097
126MP0005501_abnormal_skin_physiology0.84609855
127MP0000767_abnormal_smooth_muscle0.84523044
128MP0005390_skeleton_phenotype0.83691630
129MP0006138_congestive_heart_failure0.83393404
130MP0004145_abnormal_muscle_electrophysio0.82643561
131MP0000685_abnormal_immune_system0.82166110
132MP0001849_ear_inflammation0.82095367
133MP0002277_abnormal_respiratory_mucosa0.81868611
134MP0009053_abnormal_anal_canal0.80019175
135MP0001873_stomach_inflammation0.79580427
136MP0001216_abnormal_epidermal_layer0.78175839
137MP0009115_abnormal_fat_cell0.77853146
138MP0000598_abnormal_liver_morphology0.77835245
139MP0003045_fibrosis0.76312518
140MP0000266_abnormal_heart_morphology0.76120915
141MP0003448_altered_tumor_morphology0.75518151
142MP0008874_decreased_physiological_sensi0.75300315
143MP0000249_abnormal_blood_vessel0.74629178
144MP0005334_abnormal_fat_pad0.73788229
145MP0000490_abnormal_crypts_of0.72589814
146MP0008438_abnormal_cutaneous_collagen0.72224638
147MP0010155_abnormal_intestine_physiology0.71197341
148MP0005387_immune_system_phenotype0.70554380
149MP0001790_abnormal_immune_system0.70554380
150MP0001533_abnormal_skeleton_physiology0.70053630
151MP0003795_abnormal_bone_structure0.69032543
152MP0003091_abnormal_cell_migration0.68490719
153MP0009931_abnormal_skin_appearance0.67683148
154MP0003656_abnormal_erythrocyte_physiolo0.67282060
155MP0002405_respiratory_system_inflammati0.66630766
156MP0004484_altered_response_of0.66052709
157MP0002088_abnormal_embryonic_growth/wei0.64872541
158MP0000858_altered_metastatic_potential0.64869448
159MP0003329_amyloid_beta_deposits0.64843161
160MP0009765_abnormal_xenobiotic_induced0.64178707
161MP0003941_abnormal_skin_development0.63952618

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.95362177
2Recurrent abscess formation (HP:0002722)4.74499268
3Recurrent bacterial skin infections (HP:0005406)4.63831815
4Myositis (HP:0100614)4.49576870
5Orchitis (HP:0100796)4.44892193
6Increased connective tissue (HP:0009025)4.04901817
7Retrobulbar optic neuritis (HP:0100654)4.03892412
8Optic neuritis (HP:0100653)4.03892412
9Recurrent gram-negative bacterial infections (HP:0005420)3.99582254
10Muscle fiber splitting (HP:0003555)3.90590059
11Hyporeflexia of lower limbs (HP:0002600)3.82048605
12Right ventricular cardiomyopathy (HP:0011663)3.81475148
13Exercise-induced myalgia (HP:0003738)3.80985680
14Ventricular tachycardia (HP:0004756)3.67960931
15Stomatitis (HP:0010280)3.64665962
16Exercise-induced muscle cramps (HP:0003710)3.63935222
17Myoglobinuria (HP:0002913)3.62468526
18Chronic obstructive pulmonary disease (HP:0006510)3.58699427
19Obstructive lung disease (HP:0006536)3.58699427
20Difficulty running (HP:0009046)3.57123941
21Sudden death (HP:0001699)3.56010923
22Prolonged bleeding time (HP:0003010)3.54165820
23Spontaneous hematomas (HP:0007420)3.49412033
24Increased IgE level (HP:0003212)3.44735486
25Mediastinal lymphadenopathy (HP:0100721)3.37713339
26Gastrointestinal infarctions (HP:0005244)3.37392279
27Abnormality of liposaccharide metabolism (HP:0010968)3.29459891
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.29459891
29Abnormality of glycolipid metabolism (HP:0010969)3.29459891
30Deep venous thrombosis (HP:0002625)3.24329718
31Difficulty climbing stairs (HP:0003551)3.19674290
32Elevated erythrocyte sedimentation rate (HP:0003565)3.16766231
33Purpura (HP:0000979)3.14708420
34Keratoconjunctivitis sicca (HP:0001097)3.04873005
35Xanthomatosis (HP:0000991)3.03216513
36Polycythemia (HP:0001901)3.02326725
37Rhabdomyolysis (HP:0003201)3.02283699
38Meningitis (HP:0001287)3.00899922
39Petechiae (HP:0000967)3.00491399
40Asymmetric septal hypertrophy (HP:0001670)2.95758062
41Myocardial infarction (HP:0001658)2.94866942
42Increased cerebral lipofuscin (HP:0011813)2.93470800
43Cellulitis (HP:0100658)2.92933067
44Recurrent fungal infections (HP:0002841)2.91989417
45Gingivitis (HP:0000230)2.90498174
46Epistaxis (HP:0000421)2.87697041
47Vasculitis (HP:0002633)2.82973245
48Recurrent skin infections (HP:0001581)2.80948609
49Urticaria (HP:0001025)2.75358232
50Keratoconjunctivitis (HP:0001096)2.70098485
51Encephalitis (HP:0002383)2.68703722
52Calf muscle hypertrophy (HP:0008981)2.67986730
53Gingival bleeding (HP:0000225)2.67019394
54Loss of speech (HP:0002371)2.66956035
55Hypoalphalipoproteinemia (HP:0003233)2.66382629
56Dysostosis multiplex (HP:0000943)2.63864735
57Type 1 muscle fiber predominance (HP:0003803)2.63846842
58Hyperglycinuria (HP:0003108)2.63395451
59Amyloidosis (HP:0011034)2.61130037
60Muscle fiber inclusion bodies (HP:0100299)2.56397950
61Chest pain (HP:0100749)2.53296551
62Episodic fever (HP:0001954)2.51726627
63Arterial thrombosis (HP:0004420)2.50490019
64Hypoglycemic coma (HP:0001325)2.49857080
65Increased serum ferritin (HP:0003281)2.49273159
66Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.48828581
67Abnormality of the Achilles tendon (HP:0005109)2.47911550
68Muscle hypertrophy of the lower extremities (HP:0008968)2.46980653
69Ketosis (HP:0001946)2.44808349
70Myopathic facies (HP:0002058)2.41726041
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.40241300
72Abnormal platelet volume (HP:0011876)2.37779059
73EMG: myopathic abnormalities (HP:0003458)2.37245597
74Esophageal varix (HP:0002040)2.36965158
75Hypochromic anemia (HP:0001931)2.36180150
76Pulmonary infiltrates (HP:0002113)2.35712165
77Bundle branch block (HP:0011710)2.35356703
78Achilles tendon contracture (HP:0001771)2.34947409
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.34218573
80Abnormality of the left ventricular outflow tract (HP:0011103)2.34171620
81Subaortic stenosis (HP:0001682)2.34171620
82Gastrointestinal inflammation (HP:0004386)2.30648906
83Hypochromic microcytic anemia (HP:0004840)2.30643686
84Complement deficiency (HP:0004431)2.30146379
85Atrioventricular block (HP:0001678)2.29527982
86Ketoacidosis (HP:0001993)2.29389663
87Inflammation of the large intestine (HP:0002037)2.28396653
88Hyperammonemia (HP:0001987)2.26957319
89Recurrent viral infections (HP:0004429)2.26246588
90Abnormality of monocarboxylic acid metabolism (HP:0010996)2.23515836
91Abnormality of the calf musculature (HP:0001430)2.22966594
92Increased IgM level (HP:0003496)2.22197551
93Cerebral aneurysm (HP:0004944)2.20301313
94Pulmonary embolism (HP:0002204)2.19581274
95Hemoptysis (HP:0002105)2.18979474
96Segmental peripheral demyelination/remyelination (HP:0003481)2.18934229
97Lipoatrophy (HP:0100578)2.18136648
98Gout (HP:0001997)2.15363019
99Pustule (HP:0200039)2.14692639
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14495619
101Abnormal atrioventricular conduction (HP:0005150)2.14373705
102Abnormality of glycine metabolism (HP:0010895)2.14323187
103Abnormality of serine family amino acid metabolism (HP:0010894)2.14323187
104Hepatosplenomegaly (HP:0001433)2.13991600
105Abnormality of iron homeostasis (HP:0011031)2.13732743
106Frequent falls (HP:0002359)2.13531986
107Distal lower limb muscle weakness (HP:0009053)2.13149271
108Disinhibition (HP:0000734)2.13084345
109Intrahepatic cholestasis (HP:0001406)2.12172541
110Colitis (HP:0002583)2.12065356
111Abnormality of glutamine family amino acid metabolism (HP:0010902)2.11942174
112Ulnar deviation of the wrist (HP:0003049)2.10240581
113Vacuolated lymphocytes (HP:0001922)2.10214405
114Round ear (HP:0100830)2.10117649
115Osteomyelitis (HP:0002754)2.07113486
116Anorexia (HP:0002039)2.06661715
117Chronic mucocutaneous candidiasis (HP:0002728)2.06084088
118Recurrent cutaneous fungal infections (HP:0011370)2.06084088
119Abnormality of fatty-acid metabolism (HP:0004359)2.05972705
120Abnormality of complement system (HP:0005339)2.05644074
121Aneurysm (HP:0002617)2.05526054
122Heart block (HP:0012722)2.05418607
123Autoimmune thrombocytopenia (HP:0001973)2.05172477
124Microcytic anemia (HP:0001935)2.03596591
125Gangrene (HP:0100758)2.02928762
126Leukocytosis (HP:0001974)2.02827992
127Hypertensive crisis (HP:0100735)2.01177636
128Slow saccadic eye movements (HP:0000514)2.01158532
129Menorrhagia (HP:0000132)2.00469621
130Hypolipoproteinemia (HP:0010981)2.00000457
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.99677532
132Gastrointestinal stroma tumor (HP:0100723)1.98640304
133Nasal polyposis (HP:0100582)1.98638871
134Interstitial pulmonary disease (HP:0006530)1.97992862
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.97792364
136Abnormality of polysaccharide metabolism (HP:0011012)1.97792364
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.97792364
138Increased density of long bones (HP:0006392)1.97199785
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96235036
140Mildly elevated creatine phosphokinase (HP:0008180)1.96066787
141Hypergammaglobulinemia (HP:0010702)1.95446341
142Acne (HP:0001061)1.95304254
143Reticulocytosis (HP:0001923)1.95061243
144Abnormality of purine metabolism (HP:0004352)1.94361837
145Lymphangioma (HP:0100764)1.93922108
146Broad metatarsal (HP:0001783)1.93902746
147Systemic lupus erythematosus (HP:0002725)1.93557175
148Impaired platelet aggregation (HP:0003540)1.91497083
149Abnormal platelet function (HP:0011869)1.91497083
150Muscle stiffness (HP:0003552)1.91482675
151Areflexia of lower limbs (HP:0002522)1.91219214
152Abnormality of the peritoneum (HP:0002585)1.91101854
153Mitral valve prolapse (HP:0001634)1.90930360
154Hyperglycemia (HP:0003074)1.89405313
155Protrusio acetabuli (HP:0003179)1.89333524
156Limb-girdle muscle atrophy (HP:0003797)1.89209923
157Abnormality of the nasal mucosa (HP:0000433)1.89181834
158Hydroxyprolinuria (HP:0003080)1.88941730
159Abnormality of proline metabolism (HP:0010907)1.88941730
160EMG: neuropathic changes (HP:0003445)1.88859227
161Neonatal death (HP:0003811)1.88462861
162Cholelithiasis (HP:0001081)1.88243915
163Late onset (HP:0003584)1.88050962
164Hyperglycinemia (HP:0002154)1.86659812
165Increased variability in muscle fiber diameter (HP:0003557)1.85719582
166Distal lower limb amyotrophy (HP:0008944)1.84914702
167Sepsis (HP:0100806)1.84795806
168Skin nodule (HP:0200036)1.83374869
169Axonal loss (HP:0003447)1.83007699
170Hemorrhage of the eye (HP:0011885)1.82983851
171Abnormality of skeletal muscle fiber size (HP:0012084)1.82910460
172Upper limb amyotrophy (HP:0009129)1.82806692
173Distal upper limb amyotrophy (HP:0007149)1.82806692
174Glomerulopathy (HP:0100820)1.82640660
175Mucopolysacchariduria (HP:0008155)1.82580053
176Hyperlipoproteinemia (HP:0010980)1.81700667
177Shallow orbits (HP:0000586)1.81092320
178Eczematoid dermatitis (HP:0000976)1.79116823
179Rectal prolapse (HP:0002035)1.78785991
180Acanthosis nigricans (HP:0000956)1.77945667
181Multiple enchondromatosis (HP:0005701)1.77168844
182Facial diplegia (HP:0001349)1.75927365
183Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.74472704
184Ventricular arrhythmia (HP:0004308)1.74396745
185Nemaline bodies (HP:0003798)1.73966847
186Epidermoid cyst (HP:0200040)1.73956344
187Dilated cardiomyopathy (HP:0001644)1.73034409
188Peritonitis (HP:0002586)1.71533493
189Abnormal cartilage morphology (HP:0002763)1.71074600
190Abnormality of sulfur amino acid metabolism (HP:0004339)1.70361377

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.12497115
2RIPK44.06636936
3ERN13.50385126
4TTN3.30334170
5PKN23.04662380
6PRPF4B2.89219568
7MAP3K102.70699165
8IRAK42.60388224
9BLK2.37295720
10EEF2K2.04459157
11FGFR42.02071424
12SIK11.99798886
13CDK121.98276427
14EPHB11.88677354
15RIPK11.86646624
16PTK61.86549160
17MAP3K31.83775269
18MAP2K31.81121951
19BCKDK1.80003676
20LATS11.79559338
21MAP4K11.71660965
22DMPK1.67897217
23FES1.57615077
24TAOK11.55345955
25TNK21.52478561
26TBK11.52424305
27FGR1.51834177
28SIK31.41237829
29MAP3K131.41038085
30MAP3K111.39541210
31SMG11.38679392
32BTK1.33044272
33NEK11.31608579
34TYK21.29882091
35MAP3K71.25097985
36PDK41.23049110
37PDK31.23049110
38ICK1.22593411
39MARK21.21840031
40STK101.21094037
41SYK1.18570355
42BMX1.17914446
43PHKG11.15386253
44PHKG21.15386253
45MATK1.15330699
46OBSCN1.15266512
47TGFBR21.13175720
48CAMK1D1.12523925
49MTOR1.10721242
50EPHA31.10275111
51LRRK21.09209764
52RPS6KA41.05469451
53IRAK21.04593839
54CDC42BPA0.98143754
55SIK20.97828198
56JAK10.95420432
57LYN0.95095741
58IRAK10.92883481
59PDGFRA0.91951432
60MAPKAPK30.91173132
61STK38L0.88308454
62PRKD20.88109396
63TXK0.87166162
64CDK40.86637803
65CSF1R0.85889757
66ALK0.84732433
67STK30.83342516
68CHUK0.82699413
69CDK60.82126389
70PRKAA20.81705369
71CSK0.81156521
72JAK20.80918164
73LATS20.78978931
74FGFR30.78676295
75JAK30.78535173
76HIPK20.78279441
77PDK10.78165198
78EPHA20.77910457
79TESK20.76157649
80GRK60.75736268
81ZAP700.75721118
82LCK0.75497142
83PIK3CG0.72502904
84MAP3K50.71734709
85CAMK1G0.70940366
86PTK20.68594074
87MAP3K20.68382946
88YES10.68346274
89PRKAA10.68315658
90NEK90.68184296
91EPHB20.66419575
92DYRK1B0.66003051
93MAPK110.64397246
94MAP3K10.63540037
95BMPR20.62950945
96NME20.62936111
97PDK20.62892937
98NEK20.62871007
99KDR0.62053859
100IKBKE0.61500629
101SGK30.60991215
102MAP3K60.60957799
103MOS0.60728734
104IRAK30.60499247
105STK240.60294890
106PAK40.57753921
107TAOK30.57625223
108PRKD30.57435970
109MAP3K80.56411015
110IKBKB0.56376521
111RPS6KA10.55649504
112PIM10.55497267
113MST1R0.55182880
114MAP2K20.54443761
115GSK3A0.52761612
116LMTK20.52685293
117PRKD10.51540962
118ILK0.50216582
119GRK70.49781225
120ITK0.49319646
121RET0.48581661
122FLT30.48203202
123STK380.48122692
124TAOK20.47669099
125KSR10.46466635
126RPS6KA20.45913617
127MAP3K140.45788170
128MAPK120.43409434
129RPS6KA60.42955103
130FYN0.42683463
131DDR20.41371056
132MARK30.40993763
133HCK0.40726469
134RPS6KL10.40038218
135RPS6KC10.40038218
136PDGFRB0.39592535
137KIT0.39006797
138MAPK70.38919704
139KSR20.38144616
140MAPKAPK20.37936815
141RAF10.37797894
142PDPK10.37685555
143CDK90.37326675
144RPS6KB20.37276615
145MAPK40.35837961
146MAP2K60.35393874

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.58516206
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.59290530
3Fatty acid degradation_Homo sapiens_hsa000712.43956110
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.24092416
5Arginine biosynthesis_Homo sapiens_hsa002202.15757111
6Nitrogen metabolism_Homo sapiens_hsa009102.12289959
7Other glycan degradation_Homo sapiens_hsa005112.07887804
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03320987
9PPAR signaling pathway_Homo sapiens_hsa033202.00263854
10Tuberculosis_Homo sapiens_hsa051521.97432910
11Malaria_Homo sapiens_hsa051441.90861778
12Propanoate metabolism_Homo sapiens_hsa006401.90343672
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89149112
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84717937
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.82593998
16Fatty acid metabolism_Homo sapiens_hsa012121.77933060
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.77545616
18Staphylococcus aureus infection_Homo sapiens_hsa051501.77359746
19Insulin resistance_Homo sapiens_hsa049311.76171395
20Allograft rejection_Homo sapiens_hsa053301.70140297
21Tryptophan metabolism_Homo sapiens_hsa003801.69094456
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68090596
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.67088468
24Carbon metabolism_Homo sapiens_hsa012001.65392742
25Graft-versus-host disease_Homo sapiens_hsa053321.65065255
26NOD-like receptor signaling pathway_Homo sapiens_hsa046211.62241653
27Complement and coagulation cascades_Homo sapiens_hsa046101.50409848
28Chemokine signaling pathway_Homo sapiens_hsa040621.49649780
29Lysine degradation_Homo sapiens_hsa003101.47909014
30Autoimmune thyroid disease_Homo sapiens_hsa053201.47334733
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45305621
32T cell receptor signaling pathway_Homo sapiens_hsa046601.42153846
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37628482
34Non-small cell lung cancer_Homo sapiens_hsa052231.37117590
35Caffeine metabolism_Homo sapiens_hsa002321.35376146
36Hematopoietic cell lineage_Homo sapiens_hsa046401.30686674
37Lysosome_Homo sapiens_hsa041421.29352707
38Salmonella infection_Homo sapiens_hsa051321.26856916
39Pertussis_Homo sapiens_hsa051331.26675696
40Hepatitis B_Homo sapiens_hsa051611.22938581
41Phagosome_Homo sapiens_hsa041451.22112857
42Herpes simplex infection_Homo sapiens_hsa051681.21386456
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21262397
44Fat digestion and absorption_Homo sapiens_hsa049751.20736895
45African trypanosomiasis_Homo sapiens_hsa051431.17930570
46Biosynthesis of amino acids_Homo sapiens_hsa012301.17486629
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.14216113
48Platelet activation_Homo sapiens_hsa046111.13723513
49Primary immunodeficiency_Homo sapiens_hsa053401.13509975
50Acute myeloid leukemia_Homo sapiens_hsa052211.12607666
51Shigellosis_Homo sapiens_hsa051311.12441355
52Antigen processing and presentation_Homo sapiens_hsa046121.10964039
53AMPK signaling pathway_Homo sapiens_hsa041521.10618772
54Type I diabetes mellitus_Homo sapiens_hsa049401.09573883
55Butanoate metabolism_Homo sapiens_hsa006501.08158521
56Viral myocarditis_Homo sapiens_hsa054161.06984738
57Pyruvate metabolism_Homo sapiens_hsa006201.06075358
58beta-Alanine metabolism_Homo sapiens_hsa004101.03533112
59Insulin signaling pathway_Homo sapiens_hsa049101.03140361
60Rheumatoid arthritis_Homo sapiens_hsa053231.03122736
61Glycosaminoglycan degradation_Homo sapiens_hsa005311.02590222
62Selenocompound metabolism_Homo sapiens_hsa004501.02352220
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01998930
64Dilated cardiomyopathy_Homo sapiens_hsa054141.01309229
65Leishmaniasis_Homo sapiens_hsa051400.99615893
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99543945
67Starch and sucrose metabolism_Homo sapiens_hsa005000.99500423
68Bile secretion_Homo sapiens_hsa049760.99484253
69Toxoplasmosis_Homo sapiens_hsa051450.95558372
70mTOR signaling pathway_Homo sapiens_hsa041500.94538076
71Chronic myeloid leukemia_Homo sapiens_hsa052200.94223517
72Osteoclast differentiation_Homo sapiens_hsa043800.93577905
73Fatty acid biosynthesis_Homo sapiens_hsa000610.93314835
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92887329
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91160917
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.89444849
77Adherens junction_Homo sapiens_hsa045200.87750548
78Phenylalanine metabolism_Homo sapiens_hsa003600.86498991
79Intestinal immune network for IgA production_Homo sapiens_hsa046720.86447796
80Endometrial cancer_Homo sapiens_hsa052130.86400026
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86324145
82Cyanoamino acid metabolism_Homo sapiens_hsa004600.84050543
83Endocytosis_Homo sapiens_hsa041440.84008176
84Glucagon signaling pathway_Homo sapiens_hsa049220.83881090
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83805179
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.83145876
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82527683
88Asthma_Homo sapiens_hsa053100.82322768
89Amoebiasis_Homo sapiens_hsa051460.82109550
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82055723
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81991383
92Prion diseases_Homo sapiens_hsa050200.81964037
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79112527
94Pentose phosphate pathway_Homo sapiens_hsa000300.78469999
95Small cell lung cancer_Homo sapiens_hsa052220.77902915
96Bladder cancer_Homo sapiens_hsa052190.77852840
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77532253
98Peroxisome_Homo sapiens_hsa041460.77453280
99Proteoglycans in cancer_Homo sapiens_hsa052050.77245177
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.77011154
101Sulfur relay system_Homo sapiens_hsa041220.75794739
102Legionellosis_Homo sapiens_hsa051340.72606896
103Focal adhesion_Homo sapiens_hsa045100.72403994
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71872101
105Glycerolipid metabolism_Homo sapiens_hsa005610.71756110
106Leukocyte transendothelial migration_Homo sapiens_hsa046700.70933780
107ABC transporters_Homo sapiens_hsa020100.70340851
108B cell receptor signaling pathway_Homo sapiens_hsa046620.70022611
109HIF-1 signaling pathway_Homo sapiens_hsa040660.68958302
110TNF signaling pathway_Homo sapiens_hsa046680.68760925
111Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68289244
112Notch signaling pathway_Homo sapiens_hsa043300.68025795
113Epstein-Barr virus infection_Homo sapiens_hsa051690.67704336
114VEGF signaling pathway_Homo sapiens_hsa043700.67586575
115GnRH signaling pathway_Homo sapiens_hsa049120.67016624
116NF-kappa B signaling pathway_Homo sapiens_hsa040640.64825507
117Fructose and mannose metabolism_Homo sapiens_hsa000510.64690434
118Viral carcinogenesis_Homo sapiens_hsa052030.64428094
119Choline metabolism in cancer_Homo sapiens_hsa052310.63398877
120Apoptosis_Homo sapiens_hsa042100.63005855
121Toll-like receptor signaling pathway_Homo sapiens_hsa046200.60582080
122ErbB signaling pathway_Homo sapiens_hsa040120.60148576
123Prolactin signaling pathway_Homo sapiens_hsa049170.59696636
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.59127239
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58538185
126Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58270124
127Type II diabetes mellitus_Homo sapiens_hsa049300.57592791
128Arginine and proline metabolism_Homo sapiens_hsa003300.55992868
129Influenza A_Homo sapiens_hsa051640.55663386
130FoxO signaling pathway_Homo sapiens_hsa040680.54475432
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53450559
132Prostate cancer_Homo sapiens_hsa052150.53325653
133Glioma_Homo sapiens_hsa052140.53230337
134MAPK signaling pathway_Homo sapiens_hsa040100.53218112
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52822934
136Renal cell carcinoma_Homo sapiens_hsa052110.52638586
137Dorso-ventral axis formation_Homo sapiens_hsa043200.51864958
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51348074
139Pancreatic cancer_Homo sapiens_hsa052120.50074069
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49865624
141MicroRNAs in cancer_Homo sapiens_hsa052060.49320374
142Galactose metabolism_Homo sapiens_hsa000520.49312069
143Colorectal cancer_Homo sapiens_hsa052100.49240314
144Hepatitis C_Homo sapiens_hsa051600.47069579
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.45858961
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45356727
147Measles_Homo sapiens_hsa051620.44770991
148Thyroid cancer_Homo sapiens_hsa052160.44249989
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43714697
150Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43234627
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42876269
152HTLV-I infection_Homo sapiens_hsa051660.42605073
153Neurotrophin signaling pathway_Homo sapiens_hsa047220.42405762
154Rap1 signaling pathway_Homo sapiens_hsa040150.42275177
155Inositol phosphate metabolism_Homo sapiens_hsa005620.41912533
156Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40719818
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40468101

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