STKLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell-cell recognition (GO:0009988)9.83715938
2binding of sperm to zona pellucida (GO:0007339)9.82081081
3piRNA metabolic process (GO:0034587)9.75482318
4plasma membrane fusion (GO:0045026)9.52730052
5spermatid development (GO:0007286)9.26016423
6epithelial cilium movement (GO:0003351)9.10827834
7cell wall macromolecule metabolic process (GO:0044036)9.09945222
8cell wall macromolecule catabolic process (GO:0016998)9.09945222
9motile cilium assembly (GO:0044458)8.85214861
10male meiosis (GO:0007140)8.49376542
11reproduction (GO:0000003)8.48340380
12cilium movement (GO:0003341)8.24078419
13synaptonemal complex organization (GO:0070193)7.83761179
14regulation of cilium movement (GO:0003352)7.83657498
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.65795416
16synaptonemal complex assembly (GO:0007130)7.44402225
17single fertilization (GO:0007338)7.09381563
18negative regulation of inclusion body assembly (GO:0090084)6.48490387
19sperm capacitation (GO:0048240)6.24015654
20fertilization (GO:0009566)6.20088185
21spermatogenesis (GO:0007283)6.15971299
22DNA methylation involved in gamete generation (GO:0043046)6.14265742
23male gamete generation (GO:0048232)6.13743765
24behavioral response to nicotine (GO:0035095)5.94138410
25organic cation transport (GO:0015695)5.78882817
26male meiosis I (GO:0007141)5.74783171
27gamete generation (GO:0007276)5.61872059
28chromosome organization involved in meiosis (GO:0070192)5.39962291
29seminiferous tubule development (GO:0072520)5.26983438
30germ cell development (GO:0007281)5.26753622
31cellular process involved in reproduction in multicellular organism (GO:0022412)5.18334597
32regulation of inclusion body assembly (GO:0090083)5.03952919
33ventricular system development (GO:0021591)4.98173002
34microtubule depolymerization (GO:0007019)4.93342273
35meiotic nuclear division (GO:0007126)4.82403800
36meiosis I (GO:0007127)4.63219315
37cell recognition (GO:0008037)4.60337151
38regulation of microtubule-based movement (GO:0060632)4.54343021
39calcium ion-dependent exocytosis (GO:0017156)4.51956869
40meiotic cell cycle (GO:0051321)4.45108302
41negative regulation of telomere maintenance (GO:0032205)4.43799199
42multicellular organismal reproductive process (GO:0048609)4.39987748
43left/right pattern formation (GO:0060972)4.11664841
44L-fucose catabolic process (GO:0042355)3.97013120
45fucose catabolic process (GO:0019317)3.97013120
46L-fucose metabolic process (GO:0042354)3.97013120
47chromosome condensation (GO:0030261)3.96352759
48response to pheromone (GO:0019236)3.93029877
49microtubule severing (GO:0051013)3.92140310
50detection of light stimulus involved in visual perception (GO:0050908)3.89030742
51detection of light stimulus involved in sensory perception (GO:0050962)3.89030742
52protein localization to cilium (GO:0061512)3.88324672
53DNA packaging (GO:0006323)3.87397888
54glycerol ether metabolic process (GO:0006662)3.86576926
55monoubiquitinated protein deubiquitination (GO:0035520)3.84741809
56genitalia morphogenesis (GO:0035112)3.79693246
57synapsis (GO:0007129)3.73551012
58axoneme assembly (GO:0035082)3.72918137
59tryptophan catabolic process (GO:0006569)3.72053965
60indole-containing compound catabolic process (GO:0042436)3.72053965
61indolalkylamine catabolic process (GO:0046218)3.72053965
62chaperone-mediated protein complex assembly (GO:0051131)3.55358019
63amine catabolic process (GO:0009310)3.54692003
64cellular biogenic amine catabolic process (GO:0042402)3.54692003
65indolalkylamine metabolic process (GO:0006586)3.54249524
66ether metabolic process (GO:0018904)3.54052199
67sequestering of actin monomers (GO:0042989)3.49268590
68multicellular organismal development (GO:0007275)3.48658755
69kynurenine metabolic process (GO:0070189)3.46963225
70gene silencing by RNA (GO:0031047)3.43917149
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.35302167
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.31873651
73DNA deamination (GO:0045006)3.29348197
74protein complex biogenesis (GO:0070271)3.29262776
75carnitine transport (GO:0015879)3.26564960
76amino-acid betaine transport (GO:0015838)3.26564960
77protein polyglutamylation (GO:0018095)3.25769117
78single strand break repair (GO:0000012)3.25439684
79carnitine transmembrane transport (GO:1902603)3.21436475
80regulation of telomere maintenance (GO:0032204)3.21094767
81cellular response to ATP (GO:0071318)3.20386402
82synaptic transmission, cholinergic (GO:0007271)3.19618436
83negative regulation of translation, ncRNA-mediated (GO:0040033)3.19464807
84regulation of translation, ncRNA-mediated (GO:0045974)3.19464807
85negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.19464807
86gamma-aminobutyric acid transport (GO:0015812)3.16452838
87intraciliary transport (GO:0042073)3.16368040
88meiotic cell cycle process (GO:1903046)3.13913749
89mitochondrial respiratory chain complex I assembly (GO:0032981)3.12612725
90NADH dehydrogenase complex assembly (GO:0010257)3.12612725
91mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12612725
92platelet dense granule organization (GO:0060155)3.12153620
93mitochondrial respiratory chain complex assembly (GO:0033108)3.06817222
94nephron tubule morphogenesis (GO:0072078)3.06520096
95nephron epithelium morphogenesis (GO:0072088)3.06520096
96tryptophan metabolic process (GO:0006568)3.04550039
97mannosylation (GO:0097502)3.02289309
98neuronal action potential (GO:0019228)3.02129466
99lactate metabolic process (GO:0006089)2.99964966
100spermatid nucleus differentiation (GO:0007289)2.99885843
101interferon-gamma secretion (GO:0072643)2.99504998
102cellular ketone body metabolic process (GO:0046950)2.95559813
103nuclear pore complex assembly (GO:0051292)2.94806351
104respiratory chain complex IV assembly (GO:0008535)2.93724371
105protein refolding (GO:0042026)2.90606256
106microtubule-based movement (GO:0007018)2.89436344
107alditol metabolic process (GO:0019400)2.86712957
108pyrimidine nucleobase catabolic process (GO:0006208)2.86386517
109cornea development in camera-type eye (GO:0061303)2.85204004
110neural tube formation (GO:0001841)2.83727900
111protein-cofactor linkage (GO:0018065)2.83283396
112regulation of spindle checkpoint (GO:0090231)2.80193942
113photoreceptor cell development (GO:0042461)2.79655930
114cilium organization (GO:0044782)2.76742764
115water-soluble vitamin biosynthetic process (GO:0042364)2.75439683
116mitotic sister chromatid cohesion (GO:0007064)2.73927289
117regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73644107
118kidney morphogenesis (GO:0060993)2.73344613
119rhodopsin mediated signaling pathway (GO:0016056)2.72102387
120reflex (GO:0060004)2.71301818
121natural killer cell mediated immunity (GO:0002228)2.68990477
122natural killer cell mediated cytotoxicity (GO:0042267)2.68990477
123cytochrome complex assembly (GO:0017004)2.68961889
124negative regulation of skeletal muscle tissue development (GO:0048642)2.68225691
125ketone body metabolic process (GO:1902224)2.67939099
126glycolytic process (GO:0006096)2.66994417
127startle response (GO:0001964)2.66754195
128indole-containing compound metabolic process (GO:0042430)2.65762585
129sulfation (GO:0051923)2.65740933
130preassembly of GPI anchor in ER membrane (GO:0016254)2.64212637
131sexual reproduction (GO:0019953)2.63531952
132gene silencing (GO:0016458)2.61693282
133reciprocal DNA recombination (GO:0035825)2.61216460
134reciprocal meiotic recombination (GO:0007131)2.61216460
135pseudouridine synthesis (GO:0001522)2.60182974
136cilium assembly (GO:0042384)2.59930794
137peptidyl-glutamic acid modification (GO:0018200)2.58524313
138protein K11-linked deubiquitination (GO:0035871)2.58317216
139regulation of gene silencing by RNA (GO:0060966)2.57850250
140regulation of posttranscriptional gene silencing (GO:0060147)2.57850250
141regulation of gene silencing by miRNA (GO:0060964)2.57850250
142cellular component assembly involved in morphogenesis (GO:0010927)2.57552363
143regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.57340275
144nucleus organization (GO:0006997)2.55940472
145regulation of hippo signaling (GO:0035330)2.55860981
146regulation of protein polyubiquitination (GO:1902914)2.55781561
147eye photoreceptor cell development (GO:0042462)2.55455560
148negative regulation of organelle assembly (GO:1902116)2.55289287
149NAD biosynthetic process (GO:0009435)2.55125415
150somite development (GO:0061053)2.54946309
151ubiquinone biosynthetic process (GO:0006744)2.54186098
152regulation of histone H3-K9 methylation (GO:0051570)2.53372020
153RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52643290
154tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52643290
155cilium morphogenesis (GO:0060271)2.52555340
156regulation of action potential (GO:0098900)2.52444286
157polyol catabolic process (GO:0046174)2.51634533
158renal tubule morphogenesis (GO:0061333)2.50934061
159nucleoside diphosphate phosphorylation (GO:0006165)2.50803429
160rRNA catabolic process (GO:0016075)2.50788527
161centriole replication (GO:0007099)2.50126869
162transmission of nerve impulse (GO:0019226)2.49655558
163C4-dicarboxylate transport (GO:0015740)2.49449927
164regulation of cilium assembly (GO:1902017)2.49442370
165alanine transport (GO:0032328)2.48508635
166photoreceptor cell maintenance (GO:0045494)2.47584828
167glycerol metabolic process (GO:0006071)2.44574991
168estrogen biosynthetic process (GO:0006703)2.43198193
169nucleobase catabolic process (GO:0046113)2.43104269
170S-adenosylmethionine metabolic process (GO:0046500)2.42193663
171positive regulation of mitochondrial fission (GO:0090141)2.42104008
172glycerophospholipid catabolic process (GO:0046475)2.41506758
173nonmotile primary cilium assembly (GO:0035058)2.41190810
174ubiquinone metabolic process (GO:0006743)2.40538388
175regulation of meiosis I (GO:0060631)2.40485394
176retinal cone cell development (GO:0046549)2.40410669
177spinal cord motor neuron differentiation (GO:0021522)2.38928797
178regulation of glucokinase activity (GO:0033131)2.38564834
179regulation of hexokinase activity (GO:1903299)2.38564834
180cilium or flagellum-dependent cell motility (GO:0001539)12.7031993
181fusion of sperm to egg plasma membrane (GO:0007342)12.6202847
182sperm motility (GO:0030317)12.6191279
183acrosome assembly (GO:0001675)10.8524609
184sperm-egg recognition (GO:0035036)10.6485755
185acrosome reaction (GO:0007340)10.5911726
186axonemal dynein complex assembly (GO:0070286)10.3158010
187multicellular organism reproduction (GO:0032504)10.1542850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.32937372
2EZH2_22144423_ChIP-Seq_EOC_Human3.98106359
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21946961
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.11008074
5GBX2_23144817_ChIP-Seq_PC3_Human2.64893554
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36435601
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33798204
8IGF1R_20145208_ChIP-Seq_DFB_Human2.30013555
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.29069002
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.24645952
11VDR_22108803_ChIP-Seq_LS180_Human2.24403363
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20124431
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.17084807
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08713485
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3354087
16EWS_26573619_Chip-Seq_HEK293_Human1.98743819
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.98182182
18FUS_26573619_Chip-Seq_HEK293_Human1.97316061
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94998095
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94562738
21CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.92486546
22GATA1_26923725_Chip-Seq_HPCs_Mouse1.91720852
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.91377700
24TAF15_26573619_Chip-Seq_HEK293_Human1.89006778
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83511699
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79770408
27ER_23166858_ChIP-Seq_MCF-7_Human1.76063254
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75703474
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.73049338
30P300_19829295_ChIP-Seq_ESCs_Human1.72240918
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72058737
32STAT1_17558387_ChIP-Seq_HELA_Human1.71302310
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.71123766
34TP53_22573176_ChIP-Seq_HFKS_Human1.70852021
35FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70163018
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67533495
37PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66331723
38AR_21572438_ChIP-Seq_LNCaP_Human1.65379980
39ZNF274_21170338_ChIP-Seq_K562_Hela1.63980725
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.62429045
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.61132077
42MYC_18940864_ChIP-ChIP_HL60_Human1.59175061
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58575008
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55697120
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.53271829
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.52585378
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52543121
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48758284
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.46486876
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.44225088
51RNF2_27304074_Chip-Seq_NSC_Mouse1.42674404
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.40869273
53NCOR_22424771_ChIP-Seq_293T_Human1.40489294
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39233947
55CBP_20019798_ChIP-Seq_JUKART_Human1.39233947
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.37704734
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.36230996
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.36230996
59GATA3_21867929_ChIP-Seq_CD8_Mouse1.35698806
60BCAT_22108803_ChIP-Seq_LS180_Human1.35584337
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35139824
62NFE2_27457419_Chip-Seq_LIVER_Mouse1.33942445
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33582257
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32674692
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31768663
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.30200622
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30121551
68MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.29729947
69AR_25329375_ChIP-Seq_VCAP_Human1.28997483
70WDR5_24793694_ChIP-Seq_LNCAP_Human1.28933009
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28787054
72LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28170923
73ERA_21632823_ChIP-Seq_H3396_Human1.27523381
74STAT3_23295773_ChIP-Seq_U87_Human1.27432862
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27008789
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.26773934
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.26773531
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26680914
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25344772
80KDM2B_26808549_Chip-Seq_REH_Human1.23652645
81FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22763137
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22387765
83TCF4_23295773_ChIP-Seq_U87_Human1.21953798
84RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21823036
85SOX2_19829295_ChIP-Seq_ESCs_Human1.21442995
86NANOG_19829295_ChIP-Seq_ESCs_Human1.21442995
87REST_18959480_ChIP-ChIP_MESCs_Mouse1.20750695
88MYC_19829295_ChIP-Seq_ESCs_Human1.20513653
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20262955
90SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20127413
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.20084174
92CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19981444
93P53_21459846_ChIP-Seq_SAOS-2_Human1.19440447
94SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19321605
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.19159253
96EST1_17652178_ChIP-ChIP_JURKAT_Human1.19151789
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16819925
98HOXB7_26014856_ChIP-Seq_BT474_Human1.16440713
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.15505901
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.15007224
101NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14000262
102TP63_19390658_ChIP-ChIP_HaCaT_Human1.13955906
103SMAD4_21799915_ChIP-Seq_A2780_Human1.12593465
104IRF1_19129219_ChIP-ChIP_H3396_Human1.12410472
105KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.12392172
106AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12375879
107SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11965106
108TCF4_22108803_ChIP-Seq_LS180_Human1.11652185
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11390967
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11264458
111RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11007618
112PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10716931
113CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.10574472
114EED_16625203_ChIP-ChIP_MESCs_Mouse1.10469537
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10334814
116FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10081777
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09926457
118OCT4_20526341_ChIP-Seq_ESCs_Human1.09289049
119KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08758957
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07997562
121SPI1_26923725_Chip-Seq_HPCs_Mouse1.07956164
122RUNX2_22187159_ChIP-Seq_PCA_Human1.07732173
123TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07393184
124ERG_20517297_ChIP-Seq_VCAP_Human1.07128021
125EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05999562
126NANOG_20526341_ChIP-Seq_ESCs_Human1.05582644
127RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05553681
128TAF2_19829295_ChIP-Seq_ESCs_Human1.05047934
129RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04831389
130MYC_27129775_Chip-Seq_CORNEA_Mouse1.04409695
131GF1_26923725_Chip-Seq_HPCs_Mouse1.03834687
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03706672
133FLI1_21867929_ChIP-Seq_TH2_Mouse1.03589625
134EZH2_27304074_Chip-Seq_ESCs_Mouse1.03417787
135PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03337940
136SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02928163
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02236102
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.01478215
139AR_20517297_ChIP-Seq_VCAP_Human1.01438315
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01348347
141Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01120862
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.01030414
143POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00942547
144TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00942547
145BCOR_27268052_Chip-Seq_Bcells_Human1.00919468
146RARA_24833708_ChIP-Seq_LIVER_Mouse1.00381711
147TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00268750
148PRDM14_20953172_ChIP-Seq_ESCs_Human1.00195407
149DROSHA_22980978_ChIP-Seq_HELA_Human0.98792778
150CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98545870
151VDR_23849224_ChIP-Seq_CD4+_Human0.98314048
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98263215
153CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97897703
154EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97255931
155JARID2_20064375_ChIP-Seq_MESCs_Mouse0.96993226
156EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96618967
157OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96420094
158CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95757306
159VDR_24787735_ChIP-Seq_THP-1_Human0.94783051
160MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.92969544
161OCT4_18555785_Chip-Seq_ESCs_Mouse0.92865054
162SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92857788
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91511895
164MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91431921
165LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91059918
166RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89181838
167CTCF_26484167_Chip-Seq_Bcells_Mouse0.89175255
168ELF1_20517297_ChIP-Seq_JURKAT_Human0.88989395
169ESET_19884257_ChIP-Seq_ESCs_Mouse0.88759899
170LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87640865
171EZH2_27294783_Chip-Seq_NPCs_Mouse0.87551075
172GATA3_26560356_Chip-Seq_TH1_Human0.87375192
173NANOG_18555785_Chip-Seq_ESCs_Mouse0.87357663
174IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85643970
175BCL6_27268052_Chip-Seq_Bcells_Human0.84725067
176GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84520766
177P53_22387025_ChIP-Seq_ESCs_Mouse0.84170794
178ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83997180
179REST_21632747_ChIP-Seq_MESCs_Mouse0.83521322
180TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83006786
181SPI1_20517297_ChIP-Seq_HL60_Human0.82062713
182CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82004301

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.23533412
2MP0001929_abnormal_gametogenesis4.91069228
3MP0008877_abnormal_DNA_methylation4.06498755
4MP0002210_abnormal_sex_determination3.15976160
5MP0003136_yellow_coat_color3.13889069
6MP0001986_abnormal_taste_sensitivity2.96743823
7MP0002254_reproductive_system_inflammat2.96036948
8MP0002161_abnormal_fertility/fecundity2.79633339
9MP0001145_abnormal_male_reproductive2.59999082
10MP0005551_abnormal_eye_electrophysiolog2.58497116
11MP0001968_abnormal_touch/_nociception2.56499996
12MP0000685_abnormal_immune_system2.41336418
13MP0003195_calcinosis2.36590075
14MP0002735_abnormal_chemical_nociception2.36116374
15MP0002102_abnormal_ear_morphology2.28166812
16MP0000653_abnormal_sex_gland2.21269961
17MP0002638_abnormal_pupillary_reflex2.20856087
18MP0003878_abnormal_ear_physiology2.19272107
19MP0005377_hearing/vestibular/ear_phenot2.19272107
20MP0008057_abnormal_DNA_replication2.15358688
21MP0006276_abnormal_autonomic_nervous2.13003768
22MP0002736_abnormal_nociception_after2.12644682
23MP0002160_abnormal_reproductive_system2.01799808
24MP0005670_abnormal_white_adipose2.00465483
25MP0005410_abnormal_fertilization14.3254149
26MP0002837_dystrophic_cardiac_calcinosis1.99779883
27MP0006072_abnormal_retinal_apoptosis1.94699669
28MP0001835_abnormal_antigen_presentation1.93366220
29MP0004133_heterotaxia1.93244023
30MP0002653_abnormal_ependyma_morphology1.89585573
31MP0009745_abnormal_behavioral_response1.85013460
32MP0001485_abnormal_pinna_reflex1.80499280
33MP0001486_abnormal_startle_reflex1.78269943
34MP0008875_abnormal_xenobiotic_pharmacok1.77350473
35MP0004043_abnormal_pH_regulation1.76132516
36MP0004142_abnormal_muscle_tone1.74253766
37MP0005423_abnormal_somatic_nervous1.73401937
38MP0005253_abnormal_eye_physiology1.71465377
39MP0003787_abnormal_imprinting1.70009054
40MP0004885_abnormal_endolymph1.69119324
41MP0002272_abnormal_nervous_system1.67097287
42MP0000427_abnormal_hair_cycle1.65796561
43MP0006292_abnormal_olfactory_placode1.65175834
44MP0008872_abnormal_physiological_respon1.64327251
45MP0005647_abnormal_sex_gland1.61280548
46MP0005174_abnormal_tail_pigmentation1.59996736
47MP0002876_abnormal_thyroid_physiology1.54537039
48MP0001970_abnormal_pain_threshold1.54396197
49MP0004742_abnormal_vestibular_system1.53505427
50MP0004147_increased_porphyrin_level1.53310565
51MP0002733_abnormal_thermal_nociception1.48983157
52MP0002138_abnormal_hepatobiliary_system1.42704035
53MP0005171_absent_coat_pigmentation1.41117861
54MP0002557_abnormal_social/conspecific_i1.36619550
55MP0006082_CNS_inflammation1.36248892
56MP0002938_white_spotting1.35400199
57MP0004145_abnormal_muscle_electrophysio1.33030151
58MP0002067_abnormal_sensory_capabilities1.32925435
59MP0001529_abnormal_vocalization1.32737547
60MP0002064_seizures1.32458466
61MP0001873_stomach_inflammation1.32207025
62MP0001348_abnormal_lacrimal_gland1.31287100
63MP0003122_maternal_imprinting1.30253251
64MP0002572_abnormal_emotion/affect_behav1.29488637
65MP0000372_irregular_coat_pigmentation1.29243661
66MP0002282_abnormal_trachea_morphology1.28482879
67MP0003880_abnormal_central_pattern1.28065005
68MP0010386_abnormal_urinary_bladder1.27345057
69MP0002734_abnormal_mechanical_nocicepti1.27210494
70MP0003635_abnormal_synaptic_transmissio1.25606518
71MP0005386_behavior/neurological_phenoty1.24066353
72MP0004924_abnormal_behavior1.24066353
73MP0001501_abnormal_sleep_pattern1.22076966
74MP0004510_myositis1.19645795
75MP0001188_hyperpigmentation1.18624985
76MP0001919_abnormal_reproductive_system1.18398148
77MP0005623_abnormal_meninges_morphology1.17349521
78MP0005646_abnormal_pituitary_gland1.15433348
79MP0005310_abnormal_salivary_gland1.15050082
80MP0003436_decreased_susceptibility_to1.14790459
81MP0002063_abnormal_learning/memory/cond1.12606031
82MP0000631_abnormal_neuroendocrine_gland1.11946363
83MP0000569_abnormal_digit_pigmentation1.09192821
84MP0002822_catalepsy1.06167812
85MP0000538_abnormal_urinary_bladder1.06085782
86MP0003121_genomic_imprinting1.04103075
87MP0009278_abnormal_bone_marrow1.03688446
88MP0005195_abnormal_posterior_eye1.02223747
89MP0005084_abnormal_gallbladder_morpholo1.02175027
90MP0002405_respiratory_system_inflammati1.01235838
91MP0004270_analgesia1.01101350
92MP0003646_muscle_fatigue1.00213522
93MP0002752_abnormal_somatic_nervous0.99930578
94MP0000026_abnormal_inner_ear0.97884150
95MP0005389_reproductive_system_phenotype0.96425121
96MP0003890_abnormal_embryonic-extraembry0.96393458
97MP0001324_abnormal_eye_pigmentation0.96384554
98MP0000604_amyloidosis0.96257523
99MP0003137_abnormal_impulse_conducting0.95703377
100MP0000778_abnormal_nervous_system0.95650681
101MP0003718_maternal_effect0.94173516
102MP0001963_abnormal_hearing_physiology0.91266491
103MP0001765_abnormal_ion_homeostasis0.90514406
104MP0001905_abnormal_dopamine_level0.89708468
105MP0002148_abnormal_hypersensitivity_rea0.88394100
106MP0009785_altered_susceptibility_to0.86626390
107MP0005000_abnormal_immune_tolerance0.86505291
108MP0005397_hematopoietic_system_phenotyp0.85454042
109MP0001545_abnormal_hematopoietic_system0.85454042
110MP0002184_abnormal_innervation0.85377259
111MP0001790_abnormal_immune_system0.85177735
112MP0005387_immune_system_phenotype0.85177735
113MP0000383_abnormal_hair_follicle0.85104095
114MP0005025_abnormal_response_to0.85009384
115MP0008058_abnormal_DNA_repair0.84876184
116MP0002095_abnormal_skin_pigmentation0.83973178
117MP0005360_urolithiasis0.82274230
118MP0005332_abnormal_amino_acid0.81648685
119MP0002751_abnormal_autonomic_nervous0.80974514
120MP0001502_abnormal_circadian_rhythm0.78985341
121MP0002419_abnormal_innate_immunity0.78276894
122MP0008995_early_reproductive_senescence0.77598814
123MP0001346_abnormal_lacrimal_gland0.76794495
124MP0001800_abnormal_humoral_immune0.75959225
125MP0003283_abnormal_digestive_organ0.75843786
126MP0004215_abnormal_myocardial_fiber0.75165066
127MP0002229_neurodegeneration0.74958727
128MP0002723_abnormal_immune_serum0.74952581
129MP0001440_abnormal_grooming_behavior0.74233436
130MP0005085_abnormal_gallbladder_physiolo0.74201841
131MP0008007_abnormal_cellular_replicative0.72188967
132MP0001984_abnormal_olfaction0.71156176
133MP0002452_abnormal_antigen_presenting0.69898720
134MP0005671_abnormal_response_to0.68805574
135MP0003786_premature_aging0.68744411
136MP0001764_abnormal_homeostasis0.66994742
137MP0010094_abnormal_chromosome_stability0.66971920
138MP0004233_abnormal_muscle_weight0.65395304
139MP0009115_abnormal_fat_cell0.65327942
140MP0001853_heart_inflammation0.65049092
141MP0003448_altered_tumor_morphology0.63826905
142MP0010307_abnormal_tumor_latency0.63026777
143MP0002420_abnormal_adaptive_immunity0.62307054
144MP0001819_abnormal_immune_cell0.61836655
145MP0002928_abnormal_bile_duct0.60368580
146MP0005076_abnormal_cell_differentiation0.58194582
147MP0003763_abnormal_thymus_physiology0.57886415
148MP0001851_eye_inflammation0.57682599
149MP0003011_delayed_dark_adaptation0.56243907
150MP0004808_abnormal_hematopoietic_stem0.56224203
151MP0004134_abnormal_chest_morphology0.55291602
152MP0003329_amyloid_beta_deposits0.53845114
153MP0003183_abnormal_peptide_metabolism0.53299437
154MP0001845_abnormal_inflammatory_respons0.52921434
155MP0002277_abnormal_respiratory_mucosa0.52337954
156MP0000716_abnormal_immune_system0.51024589
157MP0005464_abnormal_platelet_physiology0.50776879
158MP0002398_abnormal_bone_marrow0.50700713
159MP0008469_abnormal_protein_level0.50241735
160MP0003879_abnormal_hair_cell0.48105151
161MP0002971_abnormal_brown_adipose0.47958307
162MP0002139_abnormal_hepatobiliary_system0.46548255
163MP0003303_peritoneal_inflammation0.45833170
164MP0005636_abnormal_mineral_homeostasis0.44720096
165MP0003959_abnormal_lean_body0.42382882
166MP0002006_tumorigenesis0.40676402
167MP0005645_abnormal_hypothalamus_physiol0.40597251
168MP0000358_abnormal_cell_content/0.39254290
169MP0004019_abnormal_vitamin_homeostasis0.38803991
170MP0000609_abnormal_liver_physiology0.38476887
171MP0005666_abnormal_adipose_tissue0.37410297
172MP0002429_abnormal_blood_cell0.37246772
173MP0003045_fibrosis0.36760899
174MP0004947_skin_inflammation0.36660463
175MP0000703_abnormal_thymus_morphology0.35276660
176MP0002163_abnormal_gland_morphology0.34819072
177MP0001119_abnormal_female_reproductive0.34293794
178MP0002295_abnormal_pulmonary_circulatio0.33479687
179MP0002136_abnormal_kidney_physiology0.33207867
180MP0009046_muscle_twitch0.32775547
181MP0002970_abnormal_white_adipose0.32457995
182MP0005319_abnormal_enzyme/_coenzyme0.31387139

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.18694874
2Abnormal respiratory epithelium morphology (HP:0012253)8.61907590
3Abnormal respiratory motile cilium morphology (HP:0005938)8.61907590
4Rhinitis (HP:0012384)7.73750540
5Abnormal ciliary motility (HP:0012262)7.31821876
6Nasal polyposis (HP:0100582)6.93122972
7Chronic bronchitis (HP:0004469)6.80618642
8Infertility (HP:0000789)6.23421724
9Abnormality of the nasal mucosa (HP:0000433)5.65589574
10Congenital stationary night blindness (HP:0007642)5.03481951
11Bronchiectasis (HP:0002110)4.72430919
12Bronchitis (HP:0012387)4.65442087
13Nephronophthisis (HP:0000090)4.23790097
14Pancreatic cysts (HP:0001737)4.20094202
15Recurrent sinusitis (HP:0011108)3.87712269
16Pancreatic fibrosis (HP:0100732)3.81623803
17True hermaphroditism (HP:0010459)3.52132921
18Male infertility (HP:0003251)3.51179042
19Recurrent otitis media (HP:0000403)3.43109656
20Type II lissencephaly (HP:0007260)3.41234414
21Chronic hepatic failure (HP:0100626)3.35849293
22Attenuation of retinal blood vessels (HP:0007843)3.32095855
23Abnormality of the renal medulla (HP:0100957)3.27517314
24Recurrent bronchitis (HP:0002837)3.21991049
25Hyperventilation (HP:0002883)3.17868235
26Abnormal rod and cone electroretinograms (HP:0008323)3.06731173
27Pendular nystagmus (HP:0012043)3.05684874
28Abnormal spermatogenesis (HP:0008669)2.99303894
29Gonadotropin excess (HP:0000837)2.88631190
30Abnormality of the lower motor neuron (HP:0002366)2.79255087
31Genetic anticipation (HP:0003743)2.76876694
32Inability to walk (HP:0002540)2.69119615
33Cystic liver disease (HP:0006706)2.66461738
34Abolished electroretinogram (ERG) (HP:0000550)2.62542248
35Patellar aplasia (HP:0006443)2.54221206
36Rib fusion (HP:0000902)2.53669049
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.52129869
38Tubular atrophy (HP:0000092)2.47811398
39Protruding tongue (HP:0010808)2.46229112
40Tubulointerstitial nephritis (HP:0001970)2.45168070
41Aplasia/Hypoplasia of the patella (HP:0006498)2.44764412
42Tubulointerstitial abnormality (HP:0001969)2.43880054
43Renal cortical cysts (HP:0000803)2.43525511
44Fibular hypoplasia (HP:0003038)2.43020526
45Gaze-evoked nystagmus (HP:0000640)2.40745487
46Lissencephaly (HP:0001339)2.37697827
47Progressive cerebellar ataxia (HP:0002073)2.30794732
48Bony spicule pigmentary retinopathy (HP:0007737)2.30482486
49Upper motor neuron abnormality (HP:0002127)2.29893590
50Amyotrophic lateral sclerosis (HP:0007354)2.29822035
51Hypoplasia of the capital femoral epiphysis (HP:0003090)2.27874274
52Mesangial abnormality (HP:0001966)2.27598588
53Hypoplasia of the pons (HP:0012110)2.26929541
54Tubulointerstitial fibrosis (HP:0005576)2.26793236
55Cerebellar dysplasia (HP:0007033)2.25801456
56Optic disc pallor (HP:0000543)2.24095775
57Concave nail (HP:0001598)2.23660691
58Azoospermia (HP:0000027)2.21649869
59Abnormality of the pons (HP:0007361)2.20432129
60Broad-based gait (HP:0002136)2.19629430
61Increased corneal curvature (HP:0100692)2.16314087
62Keratoconus (HP:0000563)2.16314087
63Impulsivity (HP:0100710)2.15814510
64Retinal dysplasia (HP:0007973)2.15052413
65Abnormality of midbrain morphology (HP:0002418)2.14894219
66Molar tooth sign on MRI (HP:0002419)2.14894219
67Increased CSF lactate (HP:0002490)2.13920736
68Mitochondrial inheritance (HP:0001427)2.12853725
69Polyuria (HP:0000103)2.12518020
70Gait imbalance (HP:0002141)2.11506978
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.10688802
72Birth length less than 3rd percentile (HP:0003561)2.10444958
73Severe muscular hypotonia (HP:0006829)2.08713869
74Progressive inability to walk (HP:0002505)2.08337594
75Acute necrotizing encephalopathy (HP:0006965)2.08026533
76Sclerocornea (HP:0000647)2.06033619
77Type 2 muscle fiber atrophy (HP:0003554)2.04717279
78Chorioretinal atrophy (HP:0000533)2.03793566
79Absent frontal sinuses (HP:0002688)2.03119166
80Anencephaly (HP:0002323)2.02461275
81Abnormality of alanine metabolism (HP:0010916)2.01346986
82Hyperalaninemia (HP:0003348)2.01346986
83Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01346986
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.7229953
85Dynein arm defect of respiratory motile cilia (HP:0012255)11.9403416
86Absent/shortened dynein arms (HP:0200106)11.9403416
87Abnormality of the labia minora (HP:0012880)1.98622800
88Pachygyria (HP:0001302)1.97050984
89Retrobulbar optic neuritis (HP:0100654)1.96085367
90Optic neuritis (HP:0100653)1.96085367
91Male pseudohermaphroditism (HP:0000037)1.95583345
92Congenital, generalized hypertrichosis (HP:0004540)1.94635936
93Abnormality of the renal cortex (HP:0011035)1.94585747
94Congenital primary aphakia (HP:0007707)1.94497671
95Febrile seizures (HP:0002373)1.94479644
96Medial flaring of the eyebrow (HP:0010747)1.94391306
97Chronic sinusitis (HP:0011109)1.93674853
98Supernumerary spleens (HP:0009799)1.93389101
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.92898326
100Acute encephalopathy (HP:0006846)1.92760272
101Absent epiphyses (HP:0010577)1.92541975
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92541975
103Lipid accumulation in hepatocytes (HP:0006561)1.92075586
104Myositis (HP:0100614)1.91612135
105J-shaped sella turcica (HP:0002680)1.91578343
106Abnormal albumin level (HP:0012116)1.88770882
107Hypoalbuminemia (HP:0003073)1.88770882
108Orchitis (HP:0100796)1.87761466
109Abnormality of the anterior horn cell (HP:0006802)1.87351963
110Degeneration of anterior horn cells (HP:0002398)1.87351963
111Dyskinesia (HP:0100660)1.87109958
112Bilateral microphthalmos (HP:0007633)1.85284574
113Progressive macrocephaly (HP:0004481)1.85255519
114Hypomagnesemia (HP:0002917)1.85015721
115Pigmentary retinal degeneration (HP:0001146)1.84835683
116Agitation (HP:0000713)1.84736390
117Abnormal gallbladder physiology (HP:0012438)1.84200556
118Cholecystitis (HP:0001082)1.84200556
119Large for gestational age (HP:0001520)1.84136333
120Impaired proprioception (HP:0010831)1.83933382
121Optic nerve hypoplasia (HP:0000609)1.82425856
122Small hand (HP:0200055)1.82367030
123Polyphagia (HP:0002591)1.81981104
124Nephrogenic diabetes insipidus (HP:0009806)1.81585716
125Stomach cancer (HP:0012126)1.80738780
126Recurrent gram-negative bacterial infections (HP:0005420)1.80493332
127Hepatocellular necrosis (HP:0001404)1.80272205
128Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.78840438
129Methylmalonic aciduria (HP:0012120)1.78620567
130Eczematoid dermatitis (HP:0000976)1.78119289
131Postaxial foot polydactyly (HP:0001830)1.77331652
132Oligodactyly (hands) (HP:0001180)1.77314209
133Increased hepatocellular lipid droplets (HP:0006565)1.77293754
134Hyperglycinuria (HP:0003108)1.76951155
135Absent speech (HP:0001344)1.76800826
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76696176
137Furrowed tongue (HP:0000221)1.76621779
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.76176682
139Methylmalonic acidemia (HP:0002912)1.74834081
140Stage 5 chronic kidney disease (HP:0003774)1.73680937
141Deformed sella turcica (HP:0002681)1.68864631
142Congenital hepatic fibrosis (HP:0002612)1.68343586
143Spastic tetraparesis (HP:0001285)1.67392209
14411 pairs of ribs (HP:0000878)1.64573465
145Polydipsia (HP:0001959)1.63416103
146Abnormal drinking behavior (HP:0030082)1.63416103
147Oculomotor apraxia (HP:0000657)1.62157864
148Aplasia/Hypoplasia of the fibula (HP:0006492)1.61616202
149Abnormality of permanent molar morphology (HP:0011071)1.61545934
150Abnormality of the dental root (HP:0006486)1.61545934
151Taurodontia (HP:0000679)1.61545934
152Keratoconjunctivitis (HP:0001096)1.58936293
153Abnormality of renal excretion (HP:0011036)1.58477285
154Bile duct proliferation (HP:0001408)1.55408786
155Abnormal biliary tract physiology (HP:0012439)1.55408786
156Recurrent bacterial skin infections (HP:0005406)1.52651957
157Hypoplasia of dental enamel (HP:0006297)1.51445400
158Short ribs (HP:0000773)1.50367433
159Heterotopia (HP:0002282)1.49120270
160Abnormality of molar morphology (HP:0011070)1.47940676
161Abnormality of molar (HP:0011077)1.47940676
162Vascular calcification (HP:0004934)1.45377152
163Loss of speech (HP:0002371)1.44207798
164Abnormality of the dental pulp (HP:0006479)1.43862041
165Abnormality of dentin (HP:0010299)1.43740043
166Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42750490
167Decreased central vision (HP:0007663)1.42596338
168Renal dysplasia (HP:0000110)1.40915613
169Choroideremia (HP:0001139)1.39616276
170Dyschromatopsia (HP:0007641)1.38734504
171Hemorrhage of the eye (HP:0011885)1.37328543
172Bell-shaped thorax (HP:0001591)1.34663335
173Recurrent abscess formation (HP:0002722)1.29343765
174Neurofibrillary tangles (HP:0002185)1.28066174
175Cardiovascular calcification (HP:0011915)1.28026468
176Short thorax (HP:0010306)1.26728105
177Easy fatigability (HP:0003388)1.24349324
178Nephropathy (HP:0000112)1.23920560
179Conjunctival telangiectasia (HP:0000524)1.23741975
180Microglossia (HP:0000171)1.23595878
181Postaxial hand polydactyly (HP:0001162)1.21605558
182Abnormality of the frontal sinuses (HP:0002687)1.20865305
183Short femoral neck (HP:0100864)1.19860789
184Decreased motor nerve conduction velocity (HP:0003431)1.19748100

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.24607930
2PDK48.24607930
3TESK15.83106062
4PDK25.48432126
5FRK4.76092124
6PRKD34.25702923
7ICK3.88209470
8TLK13.13628057
9ZAK3.12231787
10ADRBK23.11113476
11GRK12.93556265
12CASK2.89389544
13WNK32.48449607
14MAP4K22.44365463
15PTK2B2.33316869
16ACVR1B2.22409056
17NUAK12.21062898
18NEK22.18460080
19INSRR2.16049463
20SIK21.97853947
21MAPK131.96978240
22MARK11.94285813
23MAP3K41.93283709
24DYRK1B1.93035960
25WNK41.91732635
26MUSK1.85040751
27STK391.72810652
28PNCK1.71577838
29STK381.59282500
30MAP2K71.54146066
31OXSR11.42665253
32DYRK31.42271132
33TAOK31.38077252
34PAK31.33370645
35DAPK21.31423523
36ADRBK11.18252151
37NTRK31.17064049
38DYRK21.06610470
39MAPK151.04629069
40STK31.03063293
41PDK11.00193845
42MAPKAPK30.98411027
43MAP3K140.92087703
44STK160.89948672
45TNIK0.88933581
46MKNK20.85929227
47WNK10.84253845
48BCKDK0.83534661
49TYRO30.83485665
50CAMKK20.83412708
51PASK0.82105999
52PRKCE0.78810240
53VRK10.76864324
54PRKCI0.74827811
55PHKG20.74012585
56PHKG10.74012585
57PIK3CA0.73946984
58TRIM280.73894394
59STK110.72785295
60PIK3CG0.72084250
61TBK10.71273138
62FGFR20.69499936
63RIPK40.69128275
64ERN10.68019397
65RPS6KA50.64821329
66MAP2K40.63899005
67STK100.59060381
68CSNK1G20.58769485
69IRAK10.58281691
70ATR0.57063496
71TIE10.56612835
72TAF10.56576353
73TYK20.55425992
74PRKACA0.55148168
75EEF2K0.54694361
76CAMK2A0.54376876
77EIF2AK10.53643698
78TGFBR10.52474822
79MAPKAPK50.49933330
80PTK60.49488446
81PLK20.46367262
82DYRK1A0.46087004
83MAP4K10.45926068
84GRK70.45519385
85CSNK1G10.44998089
86PDPK10.44217398
87PKN10.43948779
88EPHA40.43449137
89PRKCQ0.42945495
90FLT30.42711407
91EPHB10.41797255
92IKBKB0.41474609
93STK38L0.39385333
94IRAK40.38935898
95PINK10.38926828
96CCNB10.38590503
97BMPR1B0.37872233
98PRKCA0.37598657
99CSNK1D0.37497717
100CHUK0.37473521
101CSNK1G30.37017119
102CHEK10.36975365
103CAMK1G0.36398513
104CAMK10.36384437
105TNK20.34831044
106MAP3K100.33519648
107MST40.33517427
108PLK40.33404968
109TTK0.33315960
110VRK20.33299650
111OBSCN0.32726282
112CSF1R0.32527164
113NTRK20.32125515
114ZAP700.31991305
115IKBKE0.31856076
116MINK10.31647644
117SYK0.31263546
118ATM0.31045236
119RPS6KA60.30411167
120CSK0.30280645
121MTOR0.30060782
122MAP2K60.30038661
123CDC70.29366211
124PRKAA20.29102196
125CHEK20.28647033
126CSNK1A10.28600617
127TAOK10.28240740
128NME10.28165740
129MAP2K20.28156610
130SGK2230.27414536
131SGK4940.27414536
132PLK10.27178511
133CDK120.26298611
134PAK10.26295740
135MAP3K30.25553882
136BTK0.24710101
137PIM10.22856802
138PAK20.21409761
139MST1R0.20981394
140RPS6KB10.19959249
141ITK0.19526533
142FGFR40.19513437
143TESK20.18767294
144CDK60.17692963
145MARK30.16729080
146MAP3K80.16132230
147LMTK20.16083851
148PRKCD0.15152108
149PRKCZ0.13637115
150RPS6KA10.13108464
151HCK0.12772540
152PRKAA10.12046051
153EGFR0.11290674
154KIT0.11085004
155STK40.10733843
156TXK0.10481526
157PBK0.10422779
158LCK0.10111447
159NEK60.09656957
160BMPR20.09497725
161PAK40.08650166
162TEC0.08597779
163TRIB30.07672141
164JAK20.07282880
165CDK40.06685677
166IRAK20.06667734
167CAMKK10.06346444
168RPS6KA40.05857167
169NEK90.05646281
170GRK60.05153034
171JAK10.05067799
172PRKCG0.04793261
173PRKACG0.04397603
174PRKDC0.04343799

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.92295597
2Pyruvate metabolism_Homo sapiens_hsa006203.68919072
3Vitamin B6 metabolism_Homo sapiens_hsa007503.61157319
4Fatty acid biosynthesis_Homo sapiens_hsa000613.46493932
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.29477157
6Phototransduction_Homo sapiens_hsa047443.23454005
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86375731
8Propanoate metabolism_Homo sapiens_hsa006402.73482566
9Linoleic acid metabolism_Homo sapiens_hsa005912.68099548
10Selenocompound metabolism_Homo sapiens_hsa004502.56942406
11Nicotine addiction_Homo sapiens_hsa050332.53355520
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.49924136
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.44722171
14Glucagon signaling pathway_Homo sapiens_hsa049222.42060352
15Antigen processing and presentation_Homo sapiens_hsa046122.37550104
16Oxidative phosphorylation_Homo sapiens_hsa001902.37397610
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35110861
18Dorso-ventral axis formation_Homo sapiens_hsa043202.29310100
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.12359729
20Nitrogen metabolism_Homo sapiens_hsa009102.06813685
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05232769
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.03533246
23Butanoate metabolism_Homo sapiens_hsa006502.03088610
24PPAR signaling pathway_Homo sapiens_hsa033201.99253530
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97846880
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.96551049
27Pentose phosphate pathway_Homo sapiens_hsa000301.94445134
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91122007
29Glycerolipid metabolism_Homo sapiens_hsa005611.84013980
30Basal transcription factors_Homo sapiens_hsa030221.84002018
31RNA polymerase_Homo sapiens_hsa030201.83967312
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.83954511
33Homologous recombination_Homo sapiens_hsa034401.80969649
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78662084
35Parkinsons disease_Homo sapiens_hsa050121.78373192
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73849445
37Fanconi anemia pathway_Homo sapiens_hsa034601.59374092
38Taste transduction_Homo sapiens_hsa047421.57693199
39Protein export_Homo sapiens_hsa030601.54700746
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53755595
41Legionellosis_Homo sapiens_hsa051341.51167853
42Tryptophan metabolism_Homo sapiens_hsa003801.49413369
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.46962379
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38384012
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.37974150
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36045334
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.34960650
48ABC transporters_Homo sapiens_hsa020101.33252838
49Fat digestion and absorption_Homo sapiens_hsa049751.27273251
50Morphine addiction_Homo sapiens_hsa050321.27147216
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25712962
52Intestinal immune network for IgA production_Homo sapiens_hsa046721.22910268
53Olfactory transduction_Homo sapiens_hsa047401.22218120
54One carbon pool by folate_Homo sapiens_hsa006701.16552366
55Osteoclast differentiation_Homo sapiens_hsa043801.14480128
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12432661
57Alzheimers disease_Homo sapiens_hsa050101.12071914
58Caffeine metabolism_Homo sapiens_hsa002321.10091193
59Fructose and mannose metabolism_Homo sapiens_hsa000511.10048996
60GABAergic synapse_Homo sapiens_hsa047271.09187306
61Fatty acid degradation_Homo sapiens_hsa000711.09134579
62Ether lipid metabolism_Homo sapiens_hsa005651.08849728
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07112777
64Ovarian steroidogenesis_Homo sapiens_hsa049131.05833273
65Glutamatergic synapse_Homo sapiens_hsa047241.05327718
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.04922689
67Carbon metabolism_Homo sapiens_hsa012001.04482452
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03787181
69Vitamin digestion and absorption_Homo sapiens_hsa049771.03094477
70Oocyte meiosis_Homo sapiens_hsa041141.03059422
71Graft-versus-host disease_Homo sapiens_hsa053321.02236967
72Serotonergic synapse_Homo sapiens_hsa047261.01518604
73Renin secretion_Homo sapiens_hsa049241.00965988
74Sulfur metabolism_Homo sapiens_hsa009201.00333771
75Measles_Homo sapiens_hsa051621.00127541
76RNA degradation_Homo sapiens_hsa030180.99797115
77B cell receptor signaling pathway_Homo sapiens_hsa046620.98329057
78Amphetamine addiction_Homo sapiens_hsa050310.96693909
79Sulfur relay system_Homo sapiens_hsa041220.94700371
80Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93633334
81Circadian entrainment_Homo sapiens_hsa047130.93173586
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.90031197
83Fatty acid metabolism_Homo sapiens_hsa012120.88199556
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87670128
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86057171
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84221464
87Allograft rejection_Homo sapiens_hsa053300.82680154
88Insulin secretion_Homo sapiens_hsa049110.80806281
89Retinol metabolism_Homo sapiens_hsa008300.79721133
90Primary immunodeficiency_Homo sapiens_hsa053400.78307643
91Influenza A_Homo sapiens_hsa051640.77307238
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.76355820
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76227533
94Toxoplasmosis_Homo sapiens_hsa051450.76160740
95Calcium signaling pathway_Homo sapiens_hsa040200.75009143
96Mineral absorption_Homo sapiens_hsa049780.74228593
97Leishmaniasis_Homo sapiens_hsa051400.73344644
98Huntingtons disease_Homo sapiens_hsa050160.73094652
99Histidine metabolism_Homo sapiens_hsa003400.72472310
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71390083
101Arachidonic acid metabolism_Homo sapiens_hsa005900.71297626
102Ribosome_Homo sapiens_hsa030100.71051175
103Regulation of autophagy_Homo sapiens_hsa041400.69983853
104Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69597954
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69340821
106Biosynthesis of amino acids_Homo sapiens_hsa012300.69000094
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68650628
108beta-Alanine metabolism_Homo sapiens_hsa004100.67260654
109Metabolic pathways_Homo sapiens_hsa011000.67064122
110Chemical carcinogenesis_Homo sapiens_hsa052040.66099079
111Dopaminergic synapse_Homo sapiens_hsa047280.64249081
112Circadian rhythm_Homo sapiens_hsa047100.61660425
113Collecting duct acid secretion_Homo sapiens_hsa049660.60350652
114Glutathione metabolism_Homo sapiens_hsa004800.59136137
115Salivary secretion_Homo sapiens_hsa049700.58023266
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57910627
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57259421
118mRNA surveillance pathway_Homo sapiens_hsa030150.55380761
119VEGF signaling pathway_Homo sapiens_hsa043700.54913477
120Steroid biosynthesis_Homo sapiens_hsa001000.54409114
121Asthma_Homo sapiens_hsa053100.54329716
122Salmonella infection_Homo sapiens_hsa051320.52668853
123T cell receptor signaling pathway_Homo sapiens_hsa046600.52298985
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52066752
125Pyrimidine metabolism_Homo sapiens_hsa002400.52049339
126Rheumatoid arthritis_Homo sapiens_hsa053230.51071555
127Hedgehog signaling pathway_Homo sapiens_hsa043400.50658826
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50620037
129Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.50591566
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50237967
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.50069085
132Complement and coagulation cascades_Homo sapiens_hsa046100.49854201
133Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49265167
134Staphylococcus aureus infection_Homo sapiens_hsa051500.49057898
135Autoimmune thyroid disease_Homo sapiens_hsa053200.48392005
136Sphingolipid metabolism_Homo sapiens_hsa006000.47574479
137Phenylalanine metabolism_Homo sapiens_hsa003600.46938595
138Cocaine addiction_Homo sapiens_hsa050300.46215623
139Cholinergic synapse_Homo sapiens_hsa047250.44064569
140Systemic lupus erythematosus_Homo sapiens_hsa053220.42132268
141Tuberculosis_Homo sapiens_hsa051520.41545127
142Viral carcinogenesis_Homo sapiens_hsa052030.40826676
143Purine metabolism_Homo sapiens_hsa002300.40734507
144Long-term depression_Homo sapiens_hsa047300.40654118
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39210182
146Type I diabetes mellitus_Homo sapiens_hsa049400.38659816
147RNA transport_Homo sapiens_hsa030130.37964217
148Phagosome_Homo sapiens_hsa041450.36782012
149Estrogen signaling pathway_Homo sapiens_hsa049150.35251869
150Inositol phosphate metabolism_Homo sapiens_hsa005620.34726132
151Thyroid hormone synthesis_Homo sapiens_hsa049180.34709318
152Bile secretion_Homo sapiens_hsa049760.34446222
153Vascular smooth muscle contraction_Homo sapiens_hsa042700.32865207
154Endocytosis_Homo sapiens_hsa041440.32224028
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30570569
156Non-homologous end-joining_Homo sapiens_hsa034500.29479961
157Nucleotide excision repair_Homo sapiens_hsa034200.28556772
158cAMP signaling pathway_Homo sapiens_hsa040240.28400926
159Basal cell carcinoma_Homo sapiens_hsa052170.27630385
160Base excision repair_Homo sapiens_hsa034100.27175070
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26678745
162Cardiac muscle contraction_Homo sapiens_hsa042600.25659771
163Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.25081884
164AMPK signaling pathway_Homo sapiens_hsa041520.23894195
165Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23731426
166Jak-STAT signaling pathway_Homo sapiens_hsa046300.22834376
167Malaria_Homo sapiens_hsa051440.20002921
168Primary bile acid biosynthesis_Homo sapiens_hsa001200.19645232
169TNF signaling pathway_Homo sapiens_hsa046680.19166739
170Peroxisome_Homo sapiens_hsa041460.18849530

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