STMN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the stathmin family of phosphoproteins. Stathmin proteins function in microtubule dynamics and signal transduction. The encoded protein plays a regulatory role in neuronal growth and is also thought to be involved in osteogenesis. Reductions in the expression of this gene have been associated with Down's syndrome and Alzheimer's disease. Alternatively spliced transcript variants have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.65739577
2pyrimidine nucleobase catabolic process (GO:0006208)5.65056338
3vocalization behavior (GO:0071625)5.18118314
4cell migration in hindbrain (GO:0021535)5.13002535
5nucleobase catabolic process (GO:0046113)5.06177798
6protein localization to synapse (GO:0035418)4.88689150
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.85416450
8synaptic vesicle exocytosis (GO:0016079)4.80373560
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76425016
10regulation of short-term neuronal synaptic plasticity (GO:0048172)4.70821182
11phenol-containing compound catabolic process (GO:0019336)4.64754416
12behavioral response to nicotine (GO:0035095)4.57102059
13layer formation in cerebral cortex (GO:0021819)4.52697079
14neuron recognition (GO:0008038)4.43673871
15proline transport (GO:0015824)4.29396848
16dendritic spine morphogenesis (GO:0060997)4.27829089
17auditory behavior (GO:0031223)4.23409522
18* negative regulation of microtubule polymerization (GO:0031115)4.17314001
19positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.04103921
20regulation of glutamate receptor signaling pathway (GO:1900449)4.01213705
21axonal fasciculation (GO:0007413)3.96314971
22regulation of synaptic vesicle exocytosis (GO:2000300)3.93098346
23neurotransmitter secretion (GO:0007269)3.92091857
24glutamate secretion (GO:0014047)3.92020832
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.88618735
26exploration behavior (GO:0035640)3.84526188
27synaptic vesicle maturation (GO:0016188)3.78692596
28catecholamine transport (GO:0051937)3.70885006
29mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.69646640
30ATP synthesis coupled proton transport (GO:0015986)3.66126335
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.66126335
32adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.63279353
33postsynaptic membrane organization (GO:0001941)3.63214952
34sympathetic nervous system development (GO:0048485)3.60914561
35sequestering of actin monomers (GO:0042989)3.60042159
36regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.58322995
37dendrite morphogenesis (GO:0048813)3.54841834
38ionotropic glutamate receptor signaling pathway (GO:0035235)3.54316451
39mechanosensory behavior (GO:0007638)3.48882874
40positive regulation of synapse assembly (GO:0051965)3.48101209
41regulation of synapse structural plasticity (GO:0051823)3.48041518
42gamma-aminobutyric acid transport (GO:0015812)3.47792964
43behavioral response to ethanol (GO:0048149)3.45568381
44locomotory exploration behavior (GO:0035641)3.43259586
45glutamate receptor signaling pathway (GO:0007215)3.42891711
46regulation of vesicle fusion (GO:0031338)3.42870116
47response to auditory stimulus (GO:0010996)3.38927840
48neurotransmitter transport (GO:0006836)3.38629606
49dopamine biosynthetic process (GO:0042416)3.36732636
50negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.34451979
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.33998649
52establishment of mitochondrion localization (GO:0051654)3.33349889
53regulation of synaptic vesicle transport (GO:1902803)3.32257984
54synapse assembly (GO:0007416)3.31271501
55establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.31172495
56mitochondrion transport along microtubule (GO:0047497)3.31172495
57neuromuscular synaptic transmission (GO:0007274)3.30518458
58axon extension (GO:0048675)3.29947705
59positive regulation of dendritic spine morphogenesis (GO:0061003)3.29926297
60retinal ganglion cell axon guidance (GO:0031290)3.28874211
61neuronal ion channel clustering (GO:0045161)3.27603367
62maternal behavior (GO:0042711)3.25564371
63neuron-neuron synaptic transmission (GO:0007270)3.24390084
64membrane depolarization during action potential (GO:0086010)3.24083584
65central nervous system projection neuron axonogenesis (GO:0021952)3.24050311
66mating behavior (GO:0007617)3.22150872
67chaperone-mediated protein transport (GO:0072321)3.20071231
68neuronal action potential propagation (GO:0019227)3.19517554
69presynaptic membrane assembly (GO:0097105)3.18036017
70regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.17718081
71short-term memory (GO:0007614)3.16689207
72adult walking behavior (GO:0007628)3.15859228
73synaptic transmission, glutamatergic (GO:0035249)3.14522468
74response to histamine (GO:0034776)3.13570131
75detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.13529332
76detection of temperature stimulus involved in sensory perception (GO:0050961)3.13529332
77regulation of neurotransmitter secretion (GO:0046928)3.13327928
78startle response (GO:0001964)3.12207672
79regulation of respiratory system process (GO:0044065)3.09900352
80calcium-mediated signaling using intracellular calcium source (GO:0035584)3.09748066
81regulation of respiratory gaseous exchange (GO:0043576)3.09090643
82regulation of neurotransmitter levels (GO:0001505)3.07923118
83cerebral cortex radially oriented cell migration (GO:0021799)3.07717758
84regulation of cAMP-dependent protein kinase activity (GO:2000479)3.07694070
85mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.07230226
86transmission of nerve impulse (GO:0019226)3.07002180
87negative regulation of axon extension (GO:0030517)3.06387011
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03883103
89neuronal action potential (GO:0019228)3.03098869
90regulation of long-term neuronal synaptic plasticity (GO:0048169)3.02951677
91neurotransmitter catabolic process (GO:0042135)3.02466099
92regulation of excitatory postsynaptic membrane potential (GO:0060079)3.01563328
93regulation of neuronal synaptic plasticity (GO:0048168)3.01222479
94synaptic transmission, cholinergic (GO:0007271)3.00742598
95synaptic vesicle endocytosis (GO:0048488)3.00081558
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.00024765
97synapse organization (GO:0050808)2.99699310
98regulation of postsynaptic membrane potential (GO:0060078)2.98706833
99catecholamine biosynthetic process (GO:0042423)2.98036795
100catechol-containing compound biosynthetic process (GO:0009713)2.98036795
101cerebellar Purkinje cell differentiation (GO:0021702)2.97034046
102regulation of synaptic transmission, glutamatergic (GO:0051966)2.96453045
103presynaptic membrane organization (GO:0097090)2.95501764
104membrane depolarization (GO:0051899)2.95225076
105neurofilament cytoskeleton organization (GO:0060052)2.94917315
106innervation (GO:0060384)2.94534665
107positive regulation of synapse maturation (GO:0090129)2.94457769
108substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.91233282
109substrate-independent telencephalic tangential migration (GO:0021826)2.91233282
110social behavior (GO:0035176)2.91029396
111intraspecies interaction between organisms (GO:0051703)2.91029396
112regulation of neurotransmitter transport (GO:0051588)2.90913919
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.90679925
114detection of temperature stimulus (GO:0016048)2.89873640
115hippocampus development (GO:0021766)2.89170359
116central nervous system neuron axonogenesis (GO:0021955)2.88797576
117positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87998607
118dopamine receptor signaling pathway (GO:0007212)2.87267766
119negative regulation of axonogenesis (GO:0050771)2.87131794
120organelle transport along microtubule (GO:0072384)2.87038179
121regulation of synapse assembly (GO:0051963)2.86837861
122dendrite development (GO:0016358)2.85665967
123fear response (GO:0042596)2.85663585
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.84696271
125regulation of dopamine secretion (GO:0014059)2.84042702
126neuron projection extension (GO:1990138)2.84001012
127G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.82946292
128neurotransmitter-gated ion channel clustering (GO:0072578)2.82796452
129regulation of axon extension (GO:0030516)2.79586490
130cell differentiation in hindbrain (GO:0021533)2.78433684
131epithelial cell differentiation involved in kidney development (GO:0035850)2.77467808
132adult behavior (GO:0030534)2.74188621
133regulation of extent of cell growth (GO:0061387)2.73195391
134positive regulation of membrane potential (GO:0045838)2.71404547
135neuron migration (GO:0001764)2.69934701
136neuron maturation (GO:0042551)2.69814041
137regulation of axon guidance (GO:1902667)2.69578877
138regulation of dendritic spine morphogenesis (GO:0061001)2.69159659
139spinal cord association neuron differentiation (GO:0021527)2.69089939
140regulation of synapse organization (GO:0050807)2.68829179

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.58391634
2GBX2_23144817_ChIP-Seq_PC3_Human3.57628282
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.14874644
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.13690328
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.04330931
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94570896
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.92133062
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.76443980
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73774592
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65874439
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65874439
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58013484
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52954680
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50102153
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35025679
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.31512021
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.31185476
18* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.28753663
19* TAF15_26573619_Chip-Seq_HEK293_Human2.28179362
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26715163
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.22659063
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.21671249
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20826169
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.16115151
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11792426
26CTBP1_25329375_ChIP-Seq_LNCAP_Human2.09454471
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.06251926
28AR_21572438_ChIP-Seq_LNCaP_Human2.05799296
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92256990
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.88195443
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82657296
32ZNF274_21170338_ChIP-Seq_K562_Hela1.82158494
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.72422490
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.72357502
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70334544
36RNF2_27304074_Chip-Seq_NSC_Mouse1.69410808
37PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68943858
38P300_19829295_ChIP-Seq_ESCs_Human1.67107378
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.64629731
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.64431183
41IGF1R_20145208_ChIP-Seq_DFB_Human1.64020496
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.61924087
43DROSHA_22980978_ChIP-Seq_HELA_Human1.61571950
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.56913480
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.55929655
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.55492560
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48580897
48VDR_22108803_ChIP-Seq_LS180_Human1.43516515
49MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41303004
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36132055
51FUS_26573619_Chip-Seq_HEK293_Human1.35435539
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34901812
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.33331125
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32816099
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32002913
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30493507
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.30344518
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.27208140
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.26804531
60AR_25329375_ChIP-Seq_VCAP_Human1.26549784
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25310371
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24456177
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24166105
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23844182
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23521124
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18560303
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17524768
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.17042913
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16494687
70* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12112204
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11989303
72* JUN_21703547_ChIP-Seq_K562_Human1.09786128
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09182933
74* RUNX2_22187159_ChIP-Seq_PCA_Human1.08174500
75MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07588830
76CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.05565343
77ER_23166858_ChIP-Seq_MCF-7_Human1.05435667
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.05038776
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04145969
80* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02287017
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99610206
82STAT3_23295773_ChIP-Seq_U87_Human0.99421741
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99239332
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99160836
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98497298
86CBP_20019798_ChIP-Seq_JUKART_Human0.97223037
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97223037
88GATA1_26923725_Chip-Seq_HPCs_Mouse0.97153427
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96460929
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96453653
91EWS_26573619_Chip-Seq_HEK293_Human0.95115827
92AHR_22903824_ChIP-Seq_MCF-7_Human0.94773108
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94563435
94* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94410473
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94132165
96AR_19668381_ChIP-Seq_PC3_Human0.94011997
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.92601818
98TAL1_26923725_Chip-Seq_HPCs_Mouse0.92325619
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91931653
100NANOG_18555785_Chip-Seq_ESCs_Mouse0.91049564
101* TCF4_23295773_ChIP-Seq_U87_Human0.90819029
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.88069774
103* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87889578
104* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87889578
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.87871474
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86337923
107STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85999138
108MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85618199
109KDM2B_26808549_Chip-Seq_REH_Human0.85146850
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.85130192
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85026609
112* BCAT_22108803_ChIP-Seq_LS180_Human0.85016125
113TP53_18474530_ChIP-ChIP_U2OS_Human0.84192996
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84101045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.20170231
2MP0003880_abnormal_central_pattern4.00004925
3MP0004270_analgesia3.96533665
4MP0006276_abnormal_autonomic_nervous3.56145162
5MP0002822_catalepsy3.52999865
6MP0003635_abnormal_synaptic_transmissio3.38176852
7MP0002734_abnormal_mechanical_nocicepti3.21190641
8MP0002735_abnormal_chemical_nociception3.14103393
9MP0001968_abnormal_touch/_nociception3.13491788
10MP0005423_abnormal_somatic_nervous2.97262872
11MP0009745_abnormal_behavioral_response2.89414151
12MP0002063_abnormal_learning/memory/cond2.82343370
13MP0002733_abnormal_thermal_nociception2.75750576
14MP0001440_abnormal_grooming_behavior2.58710427
15MP0002572_abnormal_emotion/affect_behav2.58483162
16MP0000778_abnormal_nervous_system2.57997718
17MP0001529_abnormal_vocalization2.47143071
18MP0002064_seizures2.45993137
19MP0002184_abnormal_innervation2.45692704
20MP0001970_abnormal_pain_threshold2.45626260
21MP0002736_abnormal_nociception_after2.45516266
22MP0001905_abnormal_dopamine_level2.29775805
23MP0009046_muscle_twitch2.26803372
24MP0010386_abnormal_urinary_bladder2.17046449
25MP0002272_abnormal_nervous_system2.13699914
26MP0004858_abnormal_nervous_system2.11779995
27MP0002638_abnormal_pupillary_reflex2.11484304
28MP0009379_abnormal_foot_pigmentation2.08020750
29MP0004924_abnormal_behavior2.00282299
30MP0005386_behavior/neurological_phenoty2.00282299
31MP0001486_abnormal_startle_reflex1.98939531
32MP0002067_abnormal_sensory_capabilities1.93825210
33MP0001501_abnormal_sleep_pattern1.80757191
34MP0002557_abnormal_social/conspecific_i1.78537489
35MP0004811_abnormal_neuron_physiology1.75339710
36MP0001984_abnormal_olfaction1.64612477
37MP0000955_abnormal_spinal_cord1.64173040
38MP0003123_paternal_imprinting1.63541747
39MP0001188_hyperpigmentation1.59747944
40MP0003122_maternal_imprinting1.54765237
41MP0002751_abnormal_autonomic_nervous1.52321779
42MP0004133_heterotaxia1.50347957
43MP0003890_abnormal_embryonic-extraembry1.49957715
44MP0008877_abnormal_DNA_methylation1.47772793
45MP0002882_abnormal_neuron_morphology1.47231144
46MP0005645_abnormal_hypothalamus_physiol1.41164273
47MP0003329_amyloid_beta_deposits1.39995551
48MP0002909_abnormal_adrenal_gland1.32407376
49MP0002066_abnormal_motor_capabilities/c1.31627517
50MP0000538_abnormal_urinary_bladder1.31083108
51MP0005499_abnormal_olfactory_system1.30439259
52MP0005394_taste/olfaction_phenotype1.30439259
53MP0002837_dystrophic_cardiac_calcinosis1.29226049
54MP0000751_myopathy1.27935518
55MP0002102_abnormal_ear_morphology1.26153455
56MP0008569_lethality_at_weaning1.24335726
57MP0000569_abnormal_digit_pigmentation1.21668169
58MP0004142_abnormal_muscle_tone1.21354805
59MP0002152_abnormal_brain_morphology1.19172933
60MP0008872_abnormal_physiological_respon1.17353232
61MP0008789_abnormal_olfactory_epithelium1.14148227
62MP0002653_abnormal_ependyma_morphology1.10374986
63MP0004742_abnormal_vestibular_system1.06150597
64MP0002752_abnormal_somatic_nervous1.05765842
65MP0001502_abnormal_circadian_rhythm1.01044322
66MP0005646_abnormal_pituitary_gland0.99961543
67MP0000566_synostosis0.97596991
68MP0003879_abnormal_hair_cell0.94689966
69MP0003011_delayed_dark_adaptation0.92700514
70MP0003787_abnormal_imprinting0.92023898
71MP0000631_abnormal_neuroendocrine_gland0.91301550
72MP0002069_abnormal_eating/drinking_beha0.87995388
73MP0006292_abnormal_olfactory_placode0.87616205
74MP0009780_abnormal_chondrocyte_physiolo0.86738499
75MP0003631_nervous_system_phenotype0.86239677
76MP0003861_abnormal_nervous_system0.86227773
77MP0005187_abnormal_penis_morphology0.85129538
78MP0003633_abnormal_nervous_system0.84111014
79MP0005409_darkened_coat_color0.83858297
80MP0005195_abnormal_posterior_eye0.82453073
81MP0005253_abnormal_eye_physiology0.81950749
82MP0003938_abnormal_ear_development0.81389635
83MP0001963_abnormal_hearing_physiology0.80346866
84MP0002229_neurodegeneration0.79795232
85MP0000372_irregular_coat_pigmentation0.79785239
86MP0002163_abnormal_gland_morphology0.78649399
87MP0006072_abnormal_retinal_apoptosis0.77432213
88MP0005535_abnormal_body_temperature0.77216599
89MP0004085_abnormal_heartbeat0.77173519
90MP0004885_abnormal_endolymph0.75779342
91MP0001485_abnormal_pinna_reflex0.75136253
92MP0001348_abnormal_lacrimal_gland0.75048194
93MP0002928_abnormal_bile_duct0.73027434
94MP0003119_abnormal_digestive_system0.72999287
95MP0003283_abnormal_digestive_organ0.70254477
96MP0005551_abnormal_eye_electrophysiolog0.69279984
97MP0003634_abnormal_glial_cell0.68824008
98MP0003632_abnormal_nervous_system0.67694510
99MP0004130_abnormal_muscle_cell0.66477258
100MP0008995_early_reproductive_senescence0.66120520
101MP0001299_abnormal_eye_distance/0.64672119
102MP0000026_abnormal_inner_ear0.64256728
103MP0008874_decreased_physiological_sensi0.63996374
104MP0002081_perinatal_lethality0.62264609
105MP0006035_abnormal_mitochondrial_morpho0.62200583
106MP0005084_abnormal_gallbladder_morpholo0.60325886
107MP0001943_abnormal_respiration0.60224227
108MP0001986_abnormal_taste_sensitivity0.60198052
109MP0004145_abnormal_muscle_electrophysio0.59846132
110MP0002876_abnormal_thyroid_physiology0.58906831
111MP0005379_endocrine/exocrine_gland_phen0.56160764
112MP0003121_genomic_imprinting0.56062208
113MP0010770_preweaning_lethality0.55880601
114MP0002082_postnatal_lethality0.55880601
115MP0003137_abnormal_impulse_conducting0.55200061
116MP0010769_abnormal_survival0.53088927
117MP0001664_abnormal_digestion0.53005561
118MP0002090_abnormal_vision0.51373369
119MP0000015_abnormal_ear_pigmentation0.50614763
120MP0010768_mortality/aging0.50597964

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.50356022
2Hypothermia (HP:0002045)5.37560289
3Limb dystonia (HP:0002451)5.18786480
4Focal motor seizures (HP:0011153)4.84107651
5Focal seizures (HP:0007359)4.67273690
6Visual hallucinations (HP:0002367)4.42896915
7Atonic seizures (HP:0010819)4.11618835
8Amblyopia (HP:0000646)4.05545923
9Progressive cerebellar ataxia (HP:0002073)4.01177732
10Febrile seizures (HP:0002373)3.65165436
11Absence seizures (HP:0002121)3.43419203
12Epileptic encephalopathy (HP:0200134)3.41542058
13Polyphagia (HP:0002591)3.35711416
14Orthostatic hypotension (HP:0001278)3.29311824
15Mutism (HP:0002300)3.28603547
16Acute necrotizing encephalopathy (HP:0006965)3.19121990
17Insidious onset (HP:0003587)3.15530593
18Termporal pattern (HP:0011008)3.15530593
19Generalized tonic-clonic seizures (HP:0002069)3.12618713
20Aplasia/Hypoplasia of the brainstem (HP:0007362)3.12435994
21Hypoplasia of the brainstem (HP:0002365)3.12435994
22Ankle clonus (HP:0011448)3.11670382
23Abnormality of the corticospinal tract (HP:0002492)3.07656842
24Supranuclear gaze palsy (HP:0000605)3.07571803
25Dialeptic seizures (HP:0011146)3.06738236
26Action tremor (HP:0002345)3.03958420
27Broad-based gait (HP:0002136)3.03543804
28Amyotrophic lateral sclerosis (HP:0007354)3.02832862
29Progressive macrocephaly (HP:0004481)2.95567833
30Pheochromocytoma (HP:0002666)2.89536690
31Exotropia (HP:0000577)2.88819346
32Abnormal autonomic nervous system physiology (HP:0012332)2.87993110
33Agitation (HP:0000713)2.79843473
34Cortical dysplasia (HP:0002539)2.74237464
35Abnormal mitochondria in muscle tissue (HP:0008316)2.73717336
36Cerebral inclusion bodies (HP:0100314)2.68849519
37Neuroendocrine neoplasm (HP:0100634)2.63533894
38Drooling (HP:0002307)2.63113506
39Excessive salivation (HP:0003781)2.63113506
40Gait imbalance (HP:0002141)2.62972687
41Failure to thrive in infancy (HP:0001531)2.59930537
42Molar tooth sign on MRI (HP:0002419)2.58571906
43Abnormality of midbrain morphology (HP:0002418)2.58571906
44Abnormal eating behavior (HP:0100738)2.56960524
45Progressive inability to walk (HP:0002505)2.56817739
46Spastic tetraplegia (HP:0002510)2.53298313
47Hypoventilation (HP:0002791)2.50261981
48Anxiety (HP:0000739)2.47389634
49Hyperventilation (HP:0002883)2.47189512
50Mitochondrial inheritance (HP:0001427)2.42775853
51Nephronophthisis (HP:0000090)2.42621376
52Hyperthyroidism (HP:0000836)2.42168145
53Ulnar claw (HP:0001178)2.41445563
54Urinary urgency (HP:0000012)2.41095243
55Morphological abnormality of the pyramidal tract (HP:0002062)2.39676127
56Myotonia (HP:0002486)2.38669814
57Akinesia (HP:0002304)2.37889970
58Retinal dysplasia (HP:0007973)2.37732581
59Impaired vibration sensation in the lower limbs (HP:0002166)2.37628422
60Urinary bladder sphincter dysfunction (HP:0002839)2.35242308
61Lissencephaly (HP:0001339)2.33194163
62Truncal ataxia (HP:0002078)2.31912946
63Spastic gait (HP:0002064)2.28317912
64Acute encephalopathy (HP:0006846)2.27705084
65Papilledema (HP:0001085)2.25235476
66EEG with generalized epileptiform discharges (HP:0011198)2.25093941
67Epileptiform EEG discharges (HP:0011182)2.24150298
68Genetic anticipation (HP:0003743)2.23223277
69Poor eye contact (HP:0000817)2.23150936
70Status epilepticus (HP:0002133)2.21592319
71Absent speech (HP:0001344)2.21415076
72Poor suck (HP:0002033)2.21166606
73Abnormality of pain sensation (HP:0010832)2.20560693
74Impaired pain sensation (HP:0007328)2.20560693
75Protruding tongue (HP:0010808)2.20095114
76Neurofibrillary tangles (HP:0002185)2.19084230
77Nephrogenic diabetes insipidus (HP:0009806)2.17664138
78Congenital primary aphakia (HP:0007707)2.16616088
79Hypsarrhythmia (HP:0002521)2.14161269
80Fetal akinesia sequence (HP:0001989)2.13446196
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.13105298
82Sleep apnea (HP:0010535)2.12777727
83Torticollis (HP:0000473)2.12285752
84Inability to walk (HP:0002540)2.11382676
85Abnormality of the labia minora (HP:0012880)2.09711754
86Delusions (HP:0000746)2.08438794
87Pancreatic fibrosis (HP:0100732)2.08141668
88Hemiparesis (HP:0001269)2.07842988
89Specific learning disability (HP:0001328)2.07212347
90Hepatoblastoma (HP:0002884)2.06286828
91Abnormal hair whorl (HP:0010721)2.05644134
92Chronic hepatic failure (HP:0100626)2.03532852
93Focal dystonia (HP:0004373)2.03513518
94Esotropia (HP:0000565)2.01394610
95Polymicrogyria (HP:0002126)2.01136149
96Intellectual disability, severe (HP:0010864)2.00816216
97Craniofacial dystonia (HP:0012179)2.00570866
98Depression (HP:0000716)1.99764771
99Vaginal atresia (HP:0000148)1.99380833
100True hermaphroditism (HP:0010459)1.97977479
101Postural tremor (HP:0002174)1.96943146
102Pancreatic cysts (HP:0001737)1.95552078
103Abnormal social behavior (HP:0012433)1.94579597
104Impaired social interactions (HP:0000735)1.94579597
105Optic disc pallor (HP:0000543)1.94170936
106Hypoplasia of the corpus callosum (HP:0002079)1.93001226
107Abnormality of binocular vision (HP:0011514)1.90987678
108Diplopia (HP:0000651)1.90987678
109Abnormality of salivation (HP:0100755)1.89901201
110Shoulder girdle muscle weakness (HP:0003547)1.89267442
111Shawl scrotum (HP:0000049)1.86088474
112Abnormality of the renal medulla (HP:0100957)1.85827437
113Degeneration of the lateral corticospinal tracts (HP:0002314)1.85597203
114Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85597203
115Inappropriate behavior (HP:0000719)1.85029197
116Pachygyria (HP:0001302)1.84478330
117Lower limb muscle weakness (HP:0007340)1.84294152
118Gaze-evoked nystagmus (HP:0000640)1.84084921
119Increased hepatocellular lipid droplets (HP:0006565)1.83773582
120Type II lissencephaly (HP:0007260)1.83683686
121Medial flaring of the eyebrow (HP:0010747)1.83526960
122Increased CSF lactate (HP:0002490)1.83223113
123Restlessness (HP:0000711)1.81996575
124Genital tract atresia (HP:0001827)1.81675855
125Congenital stationary night blindness (HP:0007642)1.79697654
126Muscular hypotonia of the trunk (HP:0008936)1.79407685
127Prolonged QT interval (HP:0001657)1.78753147
128Psychosis (HP:0000709)1.77646813
129Abnormality of the vocal cords (HP:0008777)1.77400207
130Abnormality of the lower motor neuron (HP:0002366)1.76446419
131Bony spicule pigmentary retinopathy (HP:0007737)1.76170287
132Dysmetria (HP:0001310)1.73802330
133Growth hormone deficiency (HP:0000824)1.72675472
134Narrow forehead (HP:0000341)1.72042973
135Oligodactyly (hands) (HP:0001180)1.64345592
136Abnormal pancreas size (HP:0012094)1.63460699

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.79040039
2NTRK33.29038352
3MAP3K43.17935876
4MAP3K93.07967362
5MAP2K72.80988821
6MINK12.79962083
7MAPK132.74045607
8MAP3K122.72981305
9CASK2.64773938
10PNCK2.59447368
11NTRK22.49194865
12GRK52.44131703
13NTRK12.39849042
14DYRK22.34436434
15MAP2K41.85736489
16PHKG21.83505586
17PHKG11.83505586
18GRK71.76606941
19UHMK11.75290148
20SIK21.73592128
21DAPK21.71689882
22PINK11.63033627
23LATS21.62347714
24PLK21.61184239
25EPHA41.51964408
26NME11.46647836
27CSNK1G21.46112703
28PAK61.36227466
29LIMK11.34498029
30CSNK1G31.32044323
31CDK51.28311279
32KSR11.25478488
33ERBB31.22463923
34DAPK11.21632397
35MAP4K21.18355575
36DYRK31.11557861
37KSR21.09734015
38TNIK1.03513471
39PRKCG1.03131753
40CDK141.01057386
41DYRK1A1.00623729
42ARAF1.00017914
43CDK180.99844146
44ADRBK10.99540330
45CDK150.95904106
46BMPR1B0.94250549
47WNK30.93043568
48CAMK2A0.89891570
49TRIM280.89228645
50DYRK1B0.88492757
51CDK11A0.86164190
52FGR0.82563303
53CAMK2B0.79383913
54MAP3K20.78572389
55CSNK1G10.78379813
56PAK30.78100228
57MAP3K60.75675901
58BCR0.72871283
59SIK30.72387245
60RIPK40.72363277
61RET0.71843014
62MATK0.70969195
63RPS6KA20.70952896
64CDK190.70867555
65EPHA30.69247523
66PRKCE0.69223517
67FRK0.67061790
68CSNK1A1L0.67006197
69MARK20.65645242
70TAOK10.64062848
71MAP2K10.63986857
72GRK10.63772480
73EPHB20.62971639
74CAMKK10.62215751
75CAMKK20.61475592
76PRKCZ0.58464553
77GRK60.57296483
78STK110.55255263
79CAMK10.53718349
80MAPK120.53466063
81SGK4940.52948140
82SGK2230.52948140
83LMTK20.52725126
84PTK2B0.52238230
85PKN10.49764006
86SGK30.45177755
87STK160.45121944
88PRKCH0.44456446
89TYRO30.43258892
90TLK10.41631213
91FES0.40618526
92CSNK1D0.39672030
93MAP3K110.39411778
94MAPKAPK50.37734829
95PRPF4B0.37130169
96RPS6KA30.36366704
97CSNK1E0.36173713
98ADRBK20.34925133
99CSNK1A10.34896694
100MAPK90.34776000
101OXSR10.34675107
102FYN0.34308233
103DAPK30.33703218
104ROCK20.33398773
105PRKACB0.32967881
106CAMK2D0.32843850
107MAPK150.32814198
108BMPR20.32799033
109PRKAA10.32011097
110* PRKACA0.30753838
111INSRR0.30728553
112CAMK2G0.30648767
113PRKD30.28714378
114* MAPK80.28684664
115PRKCA0.28119403
116WNK40.27310981
117* PRKCB0.26724348
118MAP2K60.26530908
119PRKG10.26000564
120PRKCI0.25988082
121CAMK1G0.25745081
122CAMK40.24531872
123SGK20.24134290
124SGK10.23406325
125PLK30.21878709

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.53424072
2Synaptic vesicle cycle_Homo sapiens_hsa047213.38713203
3Oxidative phosphorylation_Homo sapiens_hsa001903.01212008
4Parkinsons disease_Homo sapiens_hsa050122.71613602
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45009532
6Dopaminergic synapse_Homo sapiens_hsa047282.39579857
7Alzheimers disease_Homo sapiens_hsa050102.33645400
8Amphetamine addiction_Homo sapiens_hsa050312.30400490
9Olfactory transduction_Homo sapiens_hsa047402.24851487
10Glutamatergic synapse_Homo sapiens_hsa047242.16969744
11Circadian entrainment_Homo sapiens_hsa047132.16410828
12Collecting duct acid secretion_Homo sapiens_hsa049662.16276056
13Serotonergic synapse_Homo sapiens_hsa047262.16232184
14Long-term potentiation_Homo sapiens_hsa047202.15438262
15GABAergic synapse_Homo sapiens_hsa047272.14610335
16Cholinergic synapse_Homo sapiens_hsa047252.05591741
17Cocaine addiction_Homo sapiens_hsa050302.01337781
18Taste transduction_Homo sapiens_hsa047422.00410279
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.96514342
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.93286279
21Morphine addiction_Homo sapiens_hsa050321.93001924
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.89997634
23Huntingtons disease_Homo sapiens_hsa050161.88181459
24Cardiac muscle contraction_Homo sapiens_hsa042601.83960996
25Long-term depression_Homo sapiens_hsa047301.66797543
26Axon guidance_Homo sapiens_hsa043601.66697730
27Renin secretion_Homo sapiens_hsa049241.60437018
28Gap junction_Homo sapiens_hsa045401.56763862
29Salivary secretion_Homo sapiens_hsa049701.56745291
30Insulin secretion_Homo sapiens_hsa049111.53227432
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38863571
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36904966
33Gastric acid secretion_Homo sapiens_hsa049711.36029771
34Vibrio cholerae infection_Homo sapiens_hsa051101.34304071
35GnRH signaling pathway_Homo sapiens_hsa049121.31652606
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31305101
37Oxytocin signaling pathway_Homo sapiens_hsa049211.30766536
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.30446345
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27721408
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24076090
41Calcium signaling pathway_Homo sapiens_hsa040201.17070193
42Phototransduction_Homo sapiens_hsa047441.13020445
43Estrogen signaling pathway_Homo sapiens_hsa049151.05923981
44Steroid biosynthesis_Homo sapiens_hsa001001.02872433
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95826591
46Melanogenesis_Homo sapiens_hsa049160.92027162
47ErbB signaling pathway_Homo sapiens_hsa040120.91786238
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91313175
49Protein export_Homo sapiens_hsa030600.91069677
50Tyrosine metabolism_Homo sapiens_hsa003500.87847572
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87551709
52Ether lipid metabolism_Homo sapiens_hsa005650.85738085
53Alcoholism_Homo sapiens_hsa050340.85222552
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84786678
55Glioma_Homo sapiens_hsa052140.84396256
56Linoleic acid metabolism_Homo sapiens_hsa005910.83802941
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.83650042
58Oocyte meiosis_Homo sapiens_hsa041140.81479938
59Proteasome_Homo sapiens_hsa030500.81285704
60Phenylalanine metabolism_Homo sapiens_hsa003600.77873839
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76880999
62Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75897843
63Type II diabetes mellitus_Homo sapiens_hsa049300.73997432
64cAMP signaling pathway_Homo sapiens_hsa040240.73257963
65Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67046459
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66941792
67Phagosome_Homo sapiens_hsa041450.65476181
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64852163
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.64126688
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.63380838
71Dorso-ventral axis formation_Homo sapiens_hsa043200.63036322
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.60065058
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59079570
74Ovarian steroidogenesis_Homo sapiens_hsa049130.57400222
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57107832
76Colorectal cancer_Homo sapiens_hsa052100.55919634
77Tryptophan metabolism_Homo sapiens_hsa003800.54040268
78MAPK signaling pathway_Homo sapiens_hsa040100.53670777
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51867524
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50882312
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.49323340
82Pancreatic secretion_Homo sapiens_hsa049720.49302038
83VEGF signaling pathway_Homo sapiens_hsa043700.48119611
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.47739607
85Endometrial cancer_Homo sapiens_hsa052130.47640285
86Ras signaling pathway_Homo sapiens_hsa040140.46531098
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46515814
88Prion diseases_Homo sapiens_hsa050200.45905711
89Renal cell carcinoma_Homo sapiens_hsa052110.45860810
90African trypanosomiasis_Homo sapiens_hsa051430.45806136
91Insulin signaling pathway_Homo sapiens_hsa049100.44432436
92Thyroid hormone synthesis_Homo sapiens_hsa049180.43399889
93Butanoate metabolism_Homo sapiens_hsa006500.42742879
94Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41828625
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41434978
96Choline metabolism in cancer_Homo sapiens_hsa052310.41031535
97Wnt signaling pathway_Homo sapiens_hsa043100.40844214
98Dilated cardiomyopathy_Homo sapiens_hsa054140.40635805
99Glucagon signaling pathway_Homo sapiens_hsa049220.39858242
100Bile secretion_Homo sapiens_hsa049760.38054850
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37247566
102Rheumatoid arthritis_Homo sapiens_hsa053230.35645566
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35249122
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33981137
105Ribosome_Homo sapiens_hsa030100.32828261
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32438534
107Hippo signaling pathway_Homo sapiens_hsa043900.32195905
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31670200
109Rap1 signaling pathway_Homo sapiens_hsa040150.31328397
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.29748427
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29231363
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28176429
113Basal transcription factors_Homo sapiens_hsa030220.28079696
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27252741
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27057536
116Fatty acid biosynthesis_Homo sapiens_hsa000610.25565985
117Prolactin signaling pathway_Homo sapiens_hsa049170.21476311
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20772001
119Regulation of autophagy_Homo sapiens_hsa041400.20152072
120Hedgehog signaling pathway_Homo sapiens_hsa043400.20037725
121Basal cell carcinoma_Homo sapiens_hsa052170.19624599

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