

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle exocytosis (GO:0016079) | 5.46717014 |
| 2 | cellular potassium ion homeostasis (GO:0030007) | 5.35706714 |
| 3 | neuron cell-cell adhesion (GO:0007158) | 5.26454229 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.24905101 |
| 5 | vocalization behavior (GO:0071625) | 5.24036164 |
| 6 | sodium ion export (GO:0071436) | 4.96300457 |
| 7 | protein localization to synapse (GO:0035418) | 4.90635828 |
| 8 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.87183479 |
| 9 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.77848599 |
| 10 | cerebellar granule cell differentiation (GO:0021707) | 4.76826946 |
| 11 | glutamate secretion (GO:0014047) | 4.56432170 |
| 12 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.43930370 |
| 13 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.43137890 |
| 14 | synaptic vesicle maturation (GO:0016188) | 4.40132939 |
| 15 | neuronal action potential propagation (GO:0019227) | 4.38217639 |
| 16 | neuronal ion channel clustering (GO:0045161) | 4.36902675 |
| 17 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.35316955 |
| 18 | negative regulation of microtubule polymerization (GO:0031115) | 4.19308699 |
| 19 | neurotransmitter secretion (GO:0007269) | 4.13430416 |
| 20 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.09835599 |
| 21 | neuron recognition (GO:0008038) | 4.08405469 |
| 22 | L-amino acid import (GO:0043092) | 4.04705817 |
| 23 | locomotory exploration behavior (GO:0035641) | 4.01674010 |
| 24 | exploration behavior (GO:0035640) | 3.95650681 |
| 25 | neuromuscular process controlling balance (GO:0050885) | 3.93987223 |
| 26 | axon ensheathment in central nervous system (GO:0032291) | 3.92334036 |
| 27 | central nervous system myelination (GO:0022010) | 3.92334036 |
| 28 | regulation of synaptic vesicle transport (GO:1902803) | 3.91947555 |
| 29 | glutamate receptor signaling pathway (GO:0007215) | 3.91413070 |
| 30 | positive regulation of dendritic spine development (GO:0060999) | 3.91151948 |
| 31 | regulation of ARF protein signal transduction (GO:0032012) | 3.89628216 |
| 32 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.89055181 |
| 33 | auditory behavior (GO:0031223) | 3.87383938 |
| 34 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.86412488 |
| 35 | establishment of mitochondrion localization (GO:0051654) | 3.86319140 |
| 36 | potassium ion homeostasis (GO:0055075) | 3.83462597 |
| 37 | regulation of synapse maturation (GO:0090128) | 3.79119775 |
| 38 | neuron-neuron synaptic transmission (GO:0007270) | 3.78809509 |
| 39 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.75164022 |
| 40 | layer formation in cerebral cortex (GO:0021819) | 3.72603901 |
| 41 | cell migration in hindbrain (GO:0021535) | 3.72431503 |
| 42 | proline transport (GO:0015824) | 3.71828417 |
| 43 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.70687373 |
| 44 | amino acid import (GO:0043090) | 3.68136129 |
| 45 | synaptic transmission, glutamatergic (GO:0035249) | 3.65550971 |
| 46 | regulation of synapse structural plasticity (GO:0051823) | 3.62825564 |
| 47 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.59452557 |
| 48 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.58892806 |
| 49 | ATP synthesis coupled proton transport (GO:0015986) | 3.58666642 |
| 50 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.58666642 |
| 51 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.56065443 |
| 52 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.55829877 |
| 53 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.54767006 |
| 54 | neurotransmitter transport (GO:0006836) | 3.53867959 |
| 55 | cell communication by electrical coupling (GO:0010644) | 3.53638811 |
| 56 | axonal fasciculation (GO:0007413) | 3.53224320 |
| 57 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.50943072 |
| 58 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.50306663 |
| 59 | mitochondrion transport along microtubule (GO:0047497) | 3.48952398 |
| 60 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.48952398 |
| 61 | dendritic spine morphogenesis (GO:0060997) | 3.46314972 |
| 62 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.46232687 |
| 63 | potassium ion import (GO:0010107) | 3.45496807 |
| 64 | dendritic spine organization (GO:0097061) | 3.42011071 |
| 65 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.40022106 |
| 66 | synaptic vesicle endocytosis (GO:0048488) | 3.39920734 |
| 67 | postsynaptic membrane organization (GO:0001941) | 3.39877676 |
| 68 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.39042441 |
| 69 | cell differentiation in hindbrain (GO:0021533) | 3.38266778 |
| 70 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.37561858 |
| 71 | regulation of vesicle fusion (GO:0031338) | 3.35583458 |
| 72 | presynaptic membrane assembly (GO:0097105) | 3.34756842 |
| 73 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.33514719 |
| 74 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.32727706 |
| 75 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.32727706 |
| 76 | regulation of postsynaptic membrane potential (GO:0060078) | 3.29850201 |
| 77 | transmission of nerve impulse (GO:0019226) | 3.28908275 |
| 78 | response to auditory stimulus (GO:0010996) | 3.28481749 |
| 79 | regulation of neurotransmitter levels (GO:0001505) | 3.27946366 |
| 80 | response to histamine (GO:0034776) | 3.26073367 |
| 81 | positive regulation of neurotransmitter secretion (GO:0001956) | 3.25355558 |
| 82 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.24276569 |
| 83 | behavioral response to cocaine (GO:0048148) | 3.21184470 |
| 84 | regulation of glutamate secretion (GO:0014048) | 3.21103601 |
| 85 | positive regulation of synapse assembly (GO:0051965) | 3.20982812 |
| 86 | cellular sodium ion homeostasis (GO:0006883) | 3.20375080 |
| 87 | gamma-aminobutyric acid transport (GO:0015812) | 3.18564548 |
| 88 | neuromuscular synaptic transmission (GO:0007274) | 3.16839500 |
| 89 | presynaptic membrane organization (GO:0097090) | 3.16811651 |
| 90 | chaperone-mediated protein transport (GO:0072321) | 3.16602123 |
| 91 | positive regulation of synapse maturation (GO:0090129) | 3.16183411 |
| 92 | positive regulation of membrane potential (GO:0045838) | 3.16017765 |
| 93 | regulation of neurotransmitter secretion (GO:0046928) | 3.15610112 |
| 94 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.14588795 |
| 95 | dopamine receptor signaling pathway (GO:0007212) | 3.13887764 |
| 96 | cerebellar Purkinje cell layer development (GO:0021680) | 3.13744283 |
| 97 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.13336316 |
| 98 | regulation of synaptic transmission (GO:0050804) | 3.12539854 |
| 99 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.11917501 |
| 100 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.09583734 |
| 101 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.07556926 |
| 102 | long-term memory (GO:0007616) | 3.07492053 |
| 103 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.07129467 |
| 104 | mechanosensory behavior (GO:0007638) | 3.06859323 |
| 105 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.06789089 |
| 106 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 3.06475825 |
| 107 | synapse assembly (GO:0007416) | 3.06055005 |
| 108 | mating behavior (GO:0007617) | 3.06040114 |
| 109 | behavioral fear response (GO:0001662) | 3.04664836 |
| 110 | behavioral defense response (GO:0002209) | 3.04664836 |
| 111 | positive regulation of neurotransmitter transport (GO:0051590) | 3.04470819 |
| 112 | fear response (GO:0042596) | 3.03492295 |
| 113 | innervation (GO:0060384) | 3.02677287 |
| 114 | synaptic vesicle transport (GO:0048489) | 3.01603837 |
| 115 | establishment of synaptic vesicle localization (GO:0097480) | 3.01603837 |
| 116 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.00871772 |
| 117 | neuromuscular process (GO:0050905) | 3.00602121 |
| 118 | membrane depolarization (GO:0051899) | 2.99813347 |
| 119 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.99645051 |
| 120 | activation of protein kinase A activity (GO:0034199) | 2.99115201 |
| 121 | regulation of dendritic spine development (GO:0060998) | 2.97969368 |
| 122 | membrane depolarization during action potential (GO:0086010) | 2.97925167 |
| 123 | respiratory electron transport chain (GO:0022904) | 2.96713620 |
| 124 | neuromuscular process controlling posture (GO:0050884) | 2.95532240 |
| 125 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.95331721 |
| 126 | transferrin transport (GO:0033572) | 2.94922499 |
| 127 | membrane hyperpolarization (GO:0060081) | 2.94019388 |
| 128 | regulation of synaptic plasticity (GO:0048167) | 2.93839631 |
| 129 | synaptic transmission (GO:0007268) | 2.93345834 |
| 130 | long-term synaptic potentiation (GO:0060291) | 2.93300016 |
| 131 | social behavior (GO:0035176) | 2.93272269 |
| 132 | intraspecies interaction between organisms (GO:0051703) | 2.93272269 |
| 133 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.92907153 |
| 134 | electron transport chain (GO:0022900) | 2.92314961 |
| 135 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.92284498 |
| 136 | detection of calcium ion (GO:0005513) | 2.91529894 |
| 137 | regulation of neurotransmitter transport (GO:0051588) | 2.91316013 |
| 138 | regulation of protein kinase A signaling (GO:0010738) | 2.90749215 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 6.41531237 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.73823895 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.26365166 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.25439194 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.11885672 |
| 6 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.93113307 |
| 7 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.86783892 |
| 8 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.80532701 |
| 9 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.73867376 |
| 10 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.73433516 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.73433516 |
| 12 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.71883378 |
| 13 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.67288507 |
| 14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.60622832 |
| 15 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.57980820 |
| 16 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.57888291 |
| 17 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.49127650 |
| 18 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.48336427 |
| 19 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.39847106 |
| 20 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.37274842 |
| 21 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.31659897 |
| 22 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.29028854 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.25408946 |
| 24 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.25403114 |
| 25 | KDM2B_26808549_Chip-Seq_K562_Human | 2.22661570 |
| 26 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 2.16734731 |
| 27 | * RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 2.14099357 |
| 28 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 2.12587906 |
| 29 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.11953317 |
| 30 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.10822435 |
| 31 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 2.06419392 |
| 32 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 2.04377448 |
| 33 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.02205059 |
| 34 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.88560507 |
| 35 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.86524624 |
| 36 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.83863226 |
| 37 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.82281127 |
| 38 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.75993822 |
| 39 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.75581746 |
| 40 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.73258558 |
| 41 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.72565448 |
| 42 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.72395165 |
| 43 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.68717949 |
| 44 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.61735448 |
| 45 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.61694535 |
| 46 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.61264190 |
| 47 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.61189638 |
| 48 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.61164889 |
| 49 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.59933719 |
| 50 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.59555662 |
| 51 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.59483723 |
| 52 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.58404408 |
| 53 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.58266526 |
| 54 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.57271587 |
| 55 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.53670348 |
| 56 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.53258244 |
| 57 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.51990502 |
| 58 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.51355389 |
| 59 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.48471150 |
| 60 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.47464647 |
| 61 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.41603845 |
| 62 | VDR_22108803_ChIP-Seq_LS180_Human | 1.40889180 |
| 63 | * KDM2B_26808549_Chip-Seq_DND41_Human | 1.37773613 |
| 64 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.36105632 |
| 65 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.35640898 |
| 66 | * TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.34826733 |
| 67 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.33950032 |
| 68 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.33219318 |
| 69 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.31889500 |
| 70 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.30826900 |
| 71 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.30119536 |
| 72 | AR_25329375_ChIP-Seq_VCAP_Human | 1.30081435 |
| 73 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.27459575 |
| 74 | FUS_26573619_Chip-Seq_HEK293_Human | 1.27111878 |
| 75 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.25250203 |
| 76 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.24737308 |
| 77 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.24501235 |
| 78 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.24498115 |
| 79 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.24426658 |
| 80 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.22290600 |
| 81 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.22226372 |
| 82 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.22112273 |
| 83 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.21881451 |
| 84 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.19462085 |
| 85 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.18613434 |
| 86 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.17565659 |
| 87 | P68_20966046_ChIP-Seq_HELA_Human | 1.17534774 |
| 88 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.16494831 |
| 89 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.15839529 |
| 90 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.15703363 |
| 91 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.15029822 |
| 92 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.14821658 |
| 93 | OCT4_19829295_ChIP-Seq_ESCs_Human | 1.14623872 |
| 94 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.12707241 |
| 95 | JUN_21703547_ChIP-Seq_K562_Human | 1.12549344 |
| 96 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.10616682 |
| 97 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.09472459 |
| 98 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.08875734 |
| 99 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.08620046 |
| 100 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.06120201 |
| 101 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.05791665 |
| 102 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.05693982 |
| 103 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05637217 |
| 104 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.05520201 |
| 105 | STAT3_23295773_ChIP-Seq_U87_Human | 1.02796405 |
| 106 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.02085986 |
| 107 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.02019369 |
| 108 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.00967627 |
| 109 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.00844088 |
| 110 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.99832875 |
| 111 | * MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.99676583 |
| 112 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.99267427 |
| 113 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.99252957 |
| 114 | * KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.98868332 |
| 115 | TCF4_23295773_ChIP-Seq_U87_Human | 0.96536143 |
| 116 | AR_19668381_ChIP-Seq_PC3_Human | 0.96278057 |
| 117 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.96075397 |
| 118 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.95619590 |
| 119 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.95553067 |
| 120 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.95553067 |
| 121 | * DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.94902626 |
| 122 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.92704689 |
| 123 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.92265260 |
| 124 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.92195114 |
| 125 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.91904703 |
| 126 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.91705359 |
| 127 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.91331944 |
| 128 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.91313728 |
| 129 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.89379388 |
| 130 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 0.89075080 |
| 131 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.87561809 |
| 132 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.87206045 |
| 133 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.86412598 |
| 134 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.86225994 |
| 135 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.85642847 |
| 136 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.85279352 |
| 137 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.84762331 |
| 138 | KDM2B_26808549_Chip-Seq_REH_Human | 0.84166258 |
| 139 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 0.83429956 |
| 140 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.83044964 |
| 141 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.82042946 |
| 142 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.82007604 |
| 143 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.80479998 |
| 144 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.80468289 |
| 145 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.80087901 |
| 146 | SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.79475659 |
| 147 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.79338268 |
| 148 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.79338268 |
| 149 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 0.78749791 |
| 150 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.78428642 |
| 151 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.78296660 |
| 152 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.77993455 |
| 153 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.77389112 |
| 154 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.77241377 |
| 155 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.74841122 |
| 156 | SA1_27219007_Chip-Seq_Bcells_Human | 0.70787886 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.21481317 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 5.06612858 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.77249418 |
| 4 | MP0004270_analgesia | 3.57077824 |
| 5 | MP0001968_abnormal_touch/_nociception | 3.42968587 |
| 6 | MP0009745_abnormal_behavioral_response | 3.22694786 |
| 7 | MP0006276_abnormal_autonomic_nervous | 3.21798282 |
| 8 | MP0002063_abnormal_learning/memory/cond | 3.08194036 |
| 9 | MP0002735_abnormal_chemical_nociception | 3.02058282 |
| 10 | MP0002064_seizures | 2.96079104 |
| 11 | MP0002736_abnormal_nociception_after | 2.96068802 |
| 12 | MP0009046_muscle_twitch | 2.93402276 |
| 13 | MP0002734_abnormal_mechanical_nocicepti | 2.83276850 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.74130188 |
| 15 | MP0005423_abnormal_somatic_nervous | 2.63554319 |
| 16 | MP0002272_abnormal_nervous_system | 2.57843058 |
| 17 | MP0001440_abnormal_grooming_behavior | 2.50614852 |
| 18 | MP0002733_abnormal_thermal_nociception | 2.48435205 |
| 19 | MP0001529_abnormal_vocalization | 2.39538366 |
| 20 | MP0001486_abnormal_startle_reflex | 2.32986930 |
| 21 | MP0001970_abnormal_pain_threshold | 2.30448324 |
| 22 | MP0001501_abnormal_sleep_pattern | 2.23296180 |
| 23 | MP0002822_catalepsy | 2.20408825 |
| 24 | MP0002184_abnormal_innervation | 2.18776104 |
| 25 | MP0003123_paternal_imprinting | 2.15350334 |
| 26 | MP0002067_abnormal_sensory_capabilities | 2.11142975 |
| 27 | MP0000778_abnormal_nervous_system | 2.02926083 |
| 28 | MP0001905_abnormal_dopamine_level | 1.92832462 |
| 29 | MP0001984_abnormal_olfaction | 1.88695370 |
| 30 | MP0005386_behavior/neurological_phenoty | 1.86000798 |
| 31 | MP0004924_abnormal_behavior | 1.86000798 |
| 32 | MP0004858_abnormal_nervous_system | 1.84656383 |
| 33 | MP0003122_maternal_imprinting | 1.84156580 |
| 34 | MP0002557_abnormal_social/conspecific_i | 1.79912486 |
| 35 | MP0003329_amyloid_beta_deposits | 1.74023261 |
| 36 | MP0004811_abnormal_neuron_physiology | 1.66030257 |
| 37 | MP0003283_abnormal_digestive_organ | 1.64962601 |
| 38 | MP0002837_dystrophic_cardiac_calcinosis | 1.61234612 |
| 39 | MP0004142_abnormal_muscle_tone | 1.59932691 |
| 40 | MP0000955_abnormal_spinal_cord | 1.57712491 |
| 41 | MP0002882_abnormal_neuron_morphology | 1.43831015 |
| 42 | MP0002909_abnormal_adrenal_gland | 1.43035747 |
| 43 | MP0008569_lethality_at_weaning | 1.42986308 |
| 44 | MP0003690_abnormal_glial_cell | 1.40291630 |
| 45 | MP0005645_abnormal_hypothalamus_physiol | 1.39160698 |
| 46 | MP0002066_abnormal_motor_capabilities/c | 1.38867640 |
| 47 | MP0003879_abnormal_hair_cell | 1.38448544 |
| 48 | MP0001188_hyperpigmentation | 1.34287346 |
| 49 | MP0000920_abnormal_myelination | 1.31633738 |
| 50 | MP0000751_myopathy | 1.30306461 |
| 51 | MP0005646_abnormal_pituitary_gland | 1.27008639 |
| 52 | MP0001502_abnormal_circadian_rhythm | 1.23958644 |
| 53 | MP0001348_abnormal_lacrimal_gland | 1.23738763 |
| 54 | MP0003787_abnormal_imprinting | 1.20251627 |
| 55 | MP0010386_abnormal_urinary_bladder | 1.20007015 |
| 56 | MP0009780_abnormal_chondrocyte_physiolo | 1.13823590 |
| 57 | MP0001177_atelectasis | 1.07851242 |
| 58 | MP0002152_abnormal_brain_morphology | 1.07157223 |
| 59 | MP0004742_abnormal_vestibular_system | 1.06429589 |
| 60 | MP0002638_abnormal_pupillary_reflex | 1.06009868 |
| 61 | MP0008872_abnormal_physiological_respon | 1.05472902 |
| 62 | MP0005394_taste/olfaction_phenotype | 1.05342779 |
| 63 | MP0005499_abnormal_olfactory_system | 1.05342779 |
| 64 | MP0002229_neurodegeneration | 0.99060505 |
| 65 | MP0002752_abnormal_somatic_nervous | 0.96488801 |
| 66 | MP0003633_abnormal_nervous_system | 0.95157228 |
| 67 | MP0002069_abnormal_eating/drinking_beha | 0.91706050 |
| 68 | MP0001963_abnormal_hearing_physiology | 0.90679901 |
| 69 | MP0003631_nervous_system_phenotype | 0.90272998 |
| 70 | MP0005551_abnormal_eye_electrophysiolog | 0.89950928 |
| 71 | MP0002876_abnormal_thyroid_physiology | 0.89454459 |
| 72 | MP0005535_abnormal_body_temperature | 0.89203682 |
| 73 | MP0004145_abnormal_muscle_electrophysio | 0.88851928 |
| 74 | MP0009379_abnormal_foot_pigmentation | 0.86748253 |
| 75 | MP0002751_abnormal_autonomic_nervous | 0.85341896 |
| 76 | MP0002653_abnormal_ependyma_morphology | 0.84067894 |
| 77 | MP0000631_abnormal_neuroendocrine_gland | 0.82440113 |
| 78 | MP0004885_abnormal_endolymph | 0.81816364 |
| 79 | MP0001986_abnormal_taste_sensitivity | 0.81497606 |
| 80 | MP0004130_abnormal_muscle_cell | 0.80556386 |
| 81 | MP0004085_abnormal_heartbeat | 0.78660177 |
| 82 | MP0003634_abnormal_glial_cell | 0.75658635 |
| 83 | MP0008874_decreased_physiological_sensi | 0.75627981 |
| 84 | MP0000604_amyloidosis | 0.73430602 |
| 85 | MP0000013_abnormal_adipose_tissue | 0.72876627 |
| 86 | MP0001664_abnormal_digestion | 0.72392082 |
| 87 | MP0006072_abnormal_retinal_apoptosis | 0.70811507 |
| 88 | MP0005409_darkened_coat_color | 0.70424980 |
| 89 | MP0008877_abnormal_DNA_methylation | 0.70150057 |
| 90 | MP0006035_abnormal_mitochondrial_morpho | 0.68144238 |
| 91 | MP0010769_abnormal_survival | 0.66546973 |
| 92 | MP0003632_abnormal_nervous_system | 0.65667091 |
| 93 | MP0003121_genomic_imprinting | 0.63766123 |
| 94 | MP0003938_abnormal_ear_development | 0.63667429 |
| 95 | MP0000026_abnormal_inner_ear | 0.62967218 |
| 96 | MP0010768_mortality/aging | 0.62862987 |
| 97 | MP0002163_abnormal_gland_morphology | 0.62854430 |
| 98 | MP0004215_abnormal_myocardial_fiber | 0.62851114 |
| 99 | MP0004484_altered_response_of | 0.62465756 |
| 100 | MP0008789_abnormal_olfactory_epithelium | 0.61495633 |
| 101 | MP0001346_abnormal_lacrimal_gland | 0.61071645 |
| 102 | MP0003137_abnormal_impulse_conducting | 0.60517768 |
| 103 | MP0002102_abnormal_ear_morphology | 0.60327786 |
| 104 | MP0001943_abnormal_respiration | 0.59902523 |
| 105 | MP0003861_abnormal_nervous_system | 0.58696720 |
| 106 | MP0000538_abnormal_urinary_bladder | 0.58259535 |
| 107 | MP0000566_synostosis | 0.57336568 |
| 108 | MP0005379_endocrine/exocrine_gland_phen | 0.57101801 |
| 109 | MP0002249_abnormal_larynx_morphology | 0.56458383 |
| 110 | MP0001485_abnormal_pinna_reflex | 0.56392866 |
| 111 | MP0005167_abnormal_blood-brain_barrier | 0.56040259 |
| 112 | MP0002090_abnormal_vision | 0.55146551 |
| 113 | MP0005623_abnormal_meninges_morphology | 0.55054597 |
| 114 | MP0002081_perinatal_lethality | 0.53346619 |
| 115 | MP0002089_abnormal_postnatal_growth/wei | 0.53275187 |
| 116 | MP0005187_abnormal_penis_morphology | 0.52321184 |
| 117 | MP0003172_abnormal_lysosome_physiology | 0.52155054 |
| 118 | MP0003075_altered_response_to | 0.50853597 |
| 119 | MP0003956_abnormal_body_size | 0.49492997 |
| 120 | MP0002082_postnatal_lethality | 0.49365267 |
| 121 | MP0010770_preweaning_lethality | 0.49365267 |
| 122 | MP0000579_abnormal_nail_morphology | 0.48184897 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.90495499 |
| 2 | Myokymia (HP:0002411) | 6.78852388 |
| 3 | Focal seizures (HP:0007359) | 5.35633288 |
| 4 | Atonic seizures (HP:0010819) | 5.16237499 |
| 5 | Visual hallucinations (HP:0002367) | 5.15764553 |
| 6 | Febrile seizures (HP:0002373) | 4.51043022 |
| 7 | Epileptic encephalopathy (HP:0200134) | 4.33156285 |
| 8 | Absence seizures (HP:0002121) | 4.26669992 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 4.05816989 |
| 10 | Dialeptic seizures (HP:0011146) | 3.85454913 |
| 11 | Limb dystonia (HP:0002451) | 3.81594160 |
| 12 | Obstructive sleep apnea (HP:0002870) | 3.70389140 |
| 13 | Acute necrotizing encephalopathy (HP:0006965) | 3.64968697 |
| 14 | Annular pancreas (HP:0001734) | 3.62636058 |
| 15 | Generalized tonic-clonic seizures (HP:0002069) | 3.62089780 |
| 16 | Papilledema (HP:0001085) | 3.56288433 |
| 17 | Amblyopia (HP:0000646) | 3.44343987 |
| 18 | Progressive macrocephaly (HP:0004481) | 3.29092050 |
| 19 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.28388157 |
| 20 | Pheochromocytoma (HP:0002666) | 3.27190961 |
| 21 | Supranuclear gaze palsy (HP:0000605) | 3.25292398 |
| 22 | Polyphagia (HP:0002591) | 3.18577800 |
| 23 | Insomnia (HP:0100785) | 3.18200665 |
| 24 | Action tremor (HP:0002345) | 3.10085038 |
| 25 | Broad-based gait (HP:0002136) | 3.02051970 |
| 26 | Neuroendocrine neoplasm (HP:0100634) | 3.01979122 |
| 27 | Hyperventilation (HP:0002883) | 2.99286977 |
| 28 | Postural instability (HP:0002172) | 2.98956443 |
| 29 | Cerebral hypomyelination (HP:0006808) | 2.92404388 |
| 30 | Mitochondrial inheritance (HP:0001427) | 2.90066787 |
| 31 | Abnormal eating behavior (HP:0100738) | 2.89519380 |
| 32 | Progressive inability to walk (HP:0002505) | 2.87920338 |
| 33 | Anxiety (HP:0000739) | 2.86224268 |
| 34 | Sleep apnea (HP:0010535) | 2.83804328 |
| 35 | Hemiplegia (HP:0002301) | 2.81232087 |
| 36 | Peripheral hypomyelination (HP:0007182) | 2.80545541 |
| 37 | Failure to thrive in infancy (HP:0001531) | 2.77430267 |
| 38 | Truncal ataxia (HP:0002078) | 2.76671587 |
| 39 | Tetraplegia (HP:0002445) | 2.76019333 |
| 40 | Intention tremor (HP:0002080) | 2.75254757 |
| 41 | Neuronal loss in central nervous system (HP:0002529) | 2.74565433 |
| 42 | Mutism (HP:0002300) | 2.74212782 |
| 43 | Cerebral inclusion bodies (HP:0100314) | 2.71388576 |
| 44 | Acute encephalopathy (HP:0006846) | 2.71315772 |
| 45 | Status epilepticus (HP:0002133) | 2.70776087 |
| 46 | Ankle clonus (HP:0011448) | 2.70408559 |
| 47 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.68856664 |
| 48 | Insidious onset (HP:0003587) | 2.67028618 |
| 49 | Termporal pattern (HP:0011008) | 2.67028618 |
| 50 | Abnormal hair whorl (HP:0010721) | 2.59516078 |
| 51 | Delusions (HP:0000746) | 2.58282875 |
| 52 | Hypothermia (HP:0002045) | 2.51107909 |
| 53 | Gait imbalance (HP:0002141) | 2.49542973 |
| 54 | Drooling (HP:0002307) | 2.49505056 |
| 55 | Excessive salivation (HP:0003781) | 2.49505056 |
| 56 | Epileptiform EEG discharges (HP:0011182) | 2.49077338 |
| 57 | Megalencephaly (HP:0001355) | 2.47872106 |
| 58 | Apathy (HP:0000741) | 2.46139472 |
| 59 | Depression (HP:0000716) | 2.45447723 |
| 60 | Poor eye contact (HP:0000817) | 2.44553867 |
| 61 | Turricephaly (HP:0000262) | 2.44324092 |
| 62 | Poor suck (HP:0002033) | 2.44049913 |
| 63 | Abnormality of the corticospinal tract (HP:0002492) | 2.42109280 |
| 64 | Gaze-evoked nystagmus (HP:0000640) | 2.41564613 |
| 65 | EEG with generalized epileptiform discharges (HP:0011198) | 2.40651238 |
| 66 | Pointed chin (HP:0000307) | 2.40273131 |
| 67 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.38103518 |
| 68 | Dysmetria (HP:0001310) | 2.35912380 |
| 69 | Inability to walk (HP:0002540) | 2.34054518 |
| 70 | Stereotypic behavior (HP:0000733) | 2.33097106 |
| 71 | Increased CSF lactate (HP:0002490) | 2.32116095 |
| 72 | Impaired smooth pursuit (HP:0007772) | 2.31068960 |
| 73 | Diminished motivation (HP:0000745) | 2.30075388 |
| 74 | Urinary urgency (HP:0000012) | 2.29946567 |
| 75 | Clonus (HP:0002169) | 2.29442627 |
| 76 | Hypoventilation (HP:0002791) | 2.28991723 |
| 77 | Hypsarrhythmia (HP:0002521) | 2.26343212 |
| 78 | Dysdiadochokinesis (HP:0002075) | 2.25714816 |
| 79 | Spastic gait (HP:0002064) | 2.25641054 |
| 80 | Spinal canal stenosis (HP:0003416) | 2.23627947 |
| 81 | Hyperacusis (HP:0010780) | 2.22264353 |
| 82 | Neurofibrillary tangles (HP:0002185) | 2.22254473 |
| 83 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.21459045 |
| 84 | Hypoplasia of the brainstem (HP:0002365) | 2.21459045 |
| 85 | Impaired social interactions (HP:0000735) | 2.21367796 |
| 86 | Abnormal social behavior (HP:0012433) | 2.21367796 |
| 87 | Esotropia (HP:0000565) | 2.20625077 |
| 88 | Optic disc pallor (HP:0000543) | 2.20061782 |
| 89 | Spastic tetraparesis (HP:0001285) | 2.19610554 |
| 90 | Abnormality of binocular vision (HP:0011514) | 2.19294226 |
| 91 | Diplopia (HP:0000651) | 2.19294226 |
| 92 | Hemiparesis (HP:0001269) | 2.18969122 |
| 93 | Agitation (HP:0000713) | 2.17993061 |
| 94 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.16862393 |
| 95 | Fetal akinesia sequence (HP:0001989) | 2.14305668 |
| 96 | Amyotrophic lateral sclerosis (HP:0007354) | 2.07476532 |
| 97 | Hepatocellular necrosis (HP:0001404) | 2.07122854 |
| 98 | Psychosis (HP:0000709) | 2.06542569 |
| 99 | Specific learning disability (HP:0001328) | 2.06108942 |
| 100 | Ulnar claw (HP:0001178) | 2.04922018 |
| 101 | Hyperthyroidism (HP:0000836) | 2.03961541 |
| 102 | Medial flaring of the eyebrow (HP:0010747) | 2.03531358 |
| 103 | Impaired vibratory sensation (HP:0002495) | 2.03502477 |
| 104 | Lower limb asymmetry (HP:0100559) | 2.03173277 |
| 105 | Rapidly progressive (HP:0003678) | 2.01706918 |
| 106 | Myotonia (HP:0002486) | 2.01412796 |
| 107 | Bradykinesia (HP:0002067) | 2.01365963 |
| 108 | Rigidity (HP:0002063) | 2.00324264 |
| 109 | Congenital primary aphakia (HP:0007707) | 2.00103496 |
| 110 | Impaired pain sensation (HP:0007328) | 1.99808601 |
| 111 | Abnormality of pain sensation (HP:0010832) | 1.99808601 |
| 112 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.99344816 |
| 113 | Aplasia of the phalanges of the hand (HP:0009802) | 1.99344816 |
| 114 | Aplasia involving bones of the extremities (HP:0009825) | 1.99344816 |
| 115 | Focal dystonia (HP:0004373) | 1.97244850 |
| 116 | Torticollis (HP:0000473) | 1.97051537 |
| 117 | Abnormality of the lower motor neuron (HP:0002366) | 1.96747763 |
| 118 | Elfin facies (HP:0004428) | 1.96289833 |
| 119 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.95549120 |
| 120 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.95034218 |
| 121 | Retinal dysplasia (HP:0007973) | 1.88723563 |
| 122 | Scanning speech (HP:0002168) | 1.87787388 |
| 123 | Narrow nasal bridge (HP:0000446) | 1.87305867 |
| 124 | Bronchomalacia (HP:0002780) | 1.86952876 |
| 125 | Genital tract atresia (HP:0001827) | 1.86248170 |
| 126 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.86009635 |
| 127 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.86009635 |
| 128 | Neoplasm of the peripheral nervous system (HP:0100007) | 1.85677356 |
| 129 | Absent speech (HP:0001344) | 1.84989292 |
| 130 | Lower limb muscle weakness (HP:0007340) | 1.84779502 |
| 131 | Exotropia (HP:0000577) | 1.84559717 |
| 132 | Overriding aorta (HP:0002623) | 1.83042275 |
| 133 | Incomplete penetrance (HP:0003829) | 1.82423405 |
| 134 | Generalized myoclonic seizures (HP:0002123) | 1.82396276 |
| 135 | Hand muscle atrophy (HP:0009130) | 1.81919021 |
| 136 | CNS hypomyelination (HP:0003429) | 1.81849371 |
| 137 | Craniofacial dystonia (HP:0012179) | 1.81583653 |
| 138 | Nephrogenic diabetes insipidus (HP:0009806) | 1.81211737 |
| 139 | Akinesia (HP:0002304) | 1.80417495 |
| 140 | Truncus arteriosus (HP:0001660) | 1.80029679 |
| 141 | X-linked dominant inheritance (HP:0001423) | 1.79446697 |
| 142 | Leukodystrophy (HP:0002415) | 1.79267709 |
| 143 | Hypercortisolism (HP:0001578) | 1.76969102 |
| 144 | Anomalous pulmonary venous return (HP:0010772) | 1.76323519 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK3 | 4.03180431 |
| 2 | MARK1 | 3.57985139 |
| 3 | MAP3K12 | 3.52540547 |
| 4 | MAP3K9 | 3.46272863 |
| 5 | MAP3K4 | 3.19955184 |
| 6 | EPHA4 | 3.05714711 |
| 7 | MINK1 | 2.94834722 |
| 8 | MAP2K7 | 2.83295783 |
| 9 | CASK | 2.71461636 |
| 10 | GRK5 | 2.49370336 |
| 11 | PNCK | 2.46616735 |
| 12 | ARAF | 2.18777441 |
| 13 | MAP2K4 | 2.12308925 |
| 14 | RIPK4 | 1.96748600 |
| 15 | NTRK2 | 1.92430394 |
| 16 | PLK2 | 1.91737236 |
| 17 | DAPK2 | 1.87520929 |
| 18 | MAPK13 | 1.86673989 |
| 19 | NTRK1 | 1.78695810 |
| 20 | KSR2 | 1.66233932 |
| 21 | RIPK1 | 1.62156075 |
| 22 | NME1 | 1.60050534 |
| 23 | PAK6 | 1.56236949 |
| 24 | KSR1 | 1.45785742 |
| 25 | DAPK1 | 1.45473838 |
| 26 | CDK5 | 1.37360887 |
| 27 | SIK2 | 1.36675376 |
| 28 | CDK19 | 1.36253406 |
| 29 | PRKCH | 1.30134392 |
| 30 | UHMK1 | 1.28318766 |
| 31 | PRKCG | 1.25254983 |
| 32 | PHKG2 | 1.24221343 |
| 33 | PHKG1 | 1.24221343 |
| 34 | CAMKK2 | 1.22343558 |
| 35 | TNIK | 1.21518547 |
| 36 | LATS2 | 1.16619893 |
| 37 | TRIB3 | 1.11822561 |
| 38 | CAMK2A | 1.10301372 |
| 39 | GRK7 | 1.09979373 |
| 40 | MAP3K11 | 1.07184975 |
| 41 | ICK | 1.05071578 |
| 42 | CAMKK1 | 1.04415022 |
| 43 | CSNK1G2 | 1.01791620 |
| 44 | LIMK1 | 1.00563201 |
| 45 | ALK | 0.99150651 |
| 46 | CDK14 | 0.97323919 |
| 47 | MAPK12 | 0.95618914 |
| 48 | CDK18 | 0.95541840 |
| 49 | CAMK2B | 0.92478774 |
| 50 | FES | 0.91525216 |
| 51 | FGR | 0.90778500 |
| 52 | CDK15 | 0.90288401 |
| 53 | PTK2B | 0.89934789 |
| 54 | NEK6 | 0.88066034 |
| 55 | SIK3 | 0.86674904 |
| 56 | BMPR2 | 0.86081318 |
| 57 | SGK3 | 0.84995988 |
| 58 | DYRK1A | 0.82561715 |
| 59 | BCR | 0.82278706 |
| 60 | OXSR1 | 0.82074314 |
| 61 | ADRBK1 | 0.81596832 |
| 62 | CDK11A | 0.79758455 |
| 63 | DYRK2 | 0.79280391 |
| 64 | BRSK1 | 0.77749130 |
| 65 | PKN1 | 0.77026313 |
| 66 | MAP3K2 | 0.76978319 |
| 67 | CSNK1G3 | 0.76140523 |
| 68 | PAK3 | 0.73690813 |
| 69 | LMTK2 | 0.72608608 |
| 70 | FGFR2 | 0.71033495 |
| 71 | RAF1 | 0.68680673 |
| 72 | PRKCE | 0.67403009 |
| 73 | DYRK1B | 0.66808027 |
| 74 | RET | 0.66719806 |
| 75 | BRAF | 0.63667266 |
| 76 | ADRBK2 | 0.63407174 |
| 77 | CAMK4 | 0.63391857 |
| 78 | SGK223 | 0.62860290 |
| 79 | SGK494 | 0.62860290 |
| 80 | GRK6 | 0.62498422 |
| 81 | MAPK10 | 0.61728450 |
| 82 | PRPF4B | 0.61003357 |
| 83 | WNK3 | 0.60642342 |
| 84 | PINK1 | 0.58463891 |
| 85 | PDK1 | 0.58139456 |
| 86 | STK38 | 0.57798899 |
| 87 | MAP3K13 | 0.57137712 |
| 88 | CAMK2G | 0.56805633 |
| 89 | CAMK2D | 0.55310518 |
| 90 | FER | 0.55209963 |
| 91 | TYRO3 | 0.55124802 |
| 92 | STK11 | 0.52771398 |
| 93 | MAP2K1 | 0.52648449 |
| 94 | PDPK1 | 0.52307248 |
| 95 | PRKCZ | 0.51516288 |
| 96 | RPS6KA3 | 0.49836801 |
| 97 | CAMK1G | 0.49491730 |
| 98 | CAMK1 | 0.48969655 |
| 99 | MAP3K6 | 0.46476119 |
| 100 | ROCK2 | 0.44466674 |
| 101 | PRKD3 | 0.44085750 |
| 102 | TNK2 | 0.43986206 |
| 103 | SIK1 | 0.43684810 |
| 104 | TESK1 | 0.42657824 |
| 105 | PRKACA | 0.40177927 |
| 106 | RPS6KA2 | 0.39175515 |
| 107 | DAPK3 | 0.38486383 |
| 108 | SGK1 | 0.38035323 |
| 109 | WNK4 | 0.37724791 |
| 110 | MAPK8 | 0.37377483 |
| 111 | MARK2 | 0.36277241 |
| 112 | BMPR1B | 0.35920128 |
| 113 | STK39 | 0.35503777 |
| 114 | MAPKAPK5 | 0.35235125 |
| 115 | TAOK2 | 0.35178284 |
| 116 | CSNK1G1 | 0.34567746 |
| 117 | SGK2 | 0.34011286 |
| 118 | MYLK | 0.33226206 |
| 119 | AKT3 | 0.32827530 |
| 120 | IRAK2 | 0.32469937 |
| 121 | ERBB2 | 0.32190634 |
| 122 | CSNK1A1L | 0.32107596 |
| 123 | TSSK6 | 0.32104343 |
| 124 | EEF2K | 0.32051803 |
| 125 | FYN | 0.31772220 |
| 126 | ERBB3 | 0.31753420 |
| 127 | MAP3K1 | 0.30652731 |
| 128 | WNK1 | 0.29235731 |
| 129 | SRC | 0.28694831 |
| 130 | GSK3B | 0.28466834 |
| 131 | CAMK1D | 0.27833628 |
| 132 | CSNK1E | 0.26450190 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.97009781 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.70565842 |
| 3 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.11681065 |
| 4 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.66887332 |
| 5 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 2.64939066 |
| 6 | Parkinsons disease_Homo sapiens_hsa05012 | 2.59445039 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.50164755 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 2.45369155 |
| 9 | Long-term potentiation_Homo sapiens_hsa04720 | 2.43621568 |
| 10 | Circadian entrainment_Homo sapiens_hsa04713 | 2.35774782 |
| 11 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.29677530 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.28189778 |
| 13 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.27222459 |
| 14 | Morphine addiction_Homo sapiens_hsa05032 | 2.26295016 |
| 15 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.20003471 |
| 16 | Taste transduction_Homo sapiens_hsa04742 | 2.11605475 |
| 17 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.10030517 |
| 18 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.91987827 |
| 19 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.89679412 |
| 20 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.89396114 |
| 21 | Salivary secretion_Homo sapiens_hsa04970 | 1.86910442 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.82323021 |
| 23 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.77067566 |
| 24 | Insulin secretion_Homo sapiens_hsa04911 | 1.68596104 |
| 25 | Long-term depression_Homo sapiens_hsa04730 | 1.66855027 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.62862993 |
| 27 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.61549627 |
| 28 | Cocaine addiction_Homo sapiens_hsa05030 | 1.58145060 |
| 29 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.55691468 |
| 30 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.46212998 |
| 31 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.43328714 |
| 32 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.40662011 |
| 33 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.39475031 |
| 34 | Gap junction_Homo sapiens_hsa04540 | 1.34108700 |
| 35 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.29561523 |
| 36 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.29070933 |
| 37 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.28962641 |
| 38 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.28141814 |
| 39 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.22709078 |
| 40 | Phototransduction_Homo sapiens_hsa04744 | 1.19770234 |
| 41 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.11014390 |
| 42 | Axon guidance_Homo sapiens_hsa04360 | 1.10466379 |
| 43 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.97715718 |
| 44 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.96425090 |
| 45 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.90531449 |
| 46 | Melanogenesis_Homo sapiens_hsa04916 | 0.89616884 |
| 47 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.89438663 |
| 48 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.88782009 |
| 49 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.84408741 |
| 50 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.84148434 |
| 51 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.81852798 |
| 52 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.81417123 |
| 53 | Glioma_Homo sapiens_hsa05214 | 0.80598612 |
| 54 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.79693594 |
| 55 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.77178106 |
| 56 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.75611116 |
| 57 | Endometrial cancer_Homo sapiens_hsa05213 | 0.74655830 |
| 58 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.74458832 |
| 59 | Bile secretion_Homo sapiens_hsa04976 | 0.70661844 |
| 60 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.70057402 |
| 61 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.66570993 |
| 62 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.63264110 |
| 63 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.62921338 |
| 64 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.59716728 |
| 65 | Alcoholism_Homo sapiens_hsa05034 | 0.58493081 |
| 66 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.58028558 |
| 67 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.56905968 |
| 68 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.54244702 |
| 69 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.54207204 |
| 70 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.54118314 |
| 71 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.53501391 |
| 72 | Phagosome_Homo sapiens_hsa04145 | 0.52735842 |
| 73 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.51286397 |
| 74 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.50651378 |
| 75 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.48243100 |
| 76 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.47970366 |
| 77 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.47947958 |
| 78 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.47228420 |
| 79 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.47169781 |
| 80 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.45425255 |
| 81 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.44743844 |
| 82 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.44146970 |
| 83 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.43657659 |
| 84 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.42592583 |
| 85 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.42461321 |
| 86 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.41457894 |
| 87 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.41423835 |
| 88 | Prion diseases_Homo sapiens_hsa05020 | 0.39793467 |
| 89 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.39577170 |
| 90 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.39229332 |
| 91 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.37501933 |
| 92 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.34776434 |
| 93 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.34378691 |
| 94 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.33490816 |
| 95 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.33338151 |
| 96 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.32399733 |
| 97 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.31597881 |
| 98 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.30708109 |
| 99 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.30361013 |
| 100 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.30337541 |
| 101 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.29200510 |
| 102 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.28651123 |
| 103 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.28476919 |
| 104 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.28422261 |
| 105 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.27657542 |
| 106 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.27391885 |
| 107 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.26489389 |
| 108 | Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 | 0.26334908 |
| 109 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.26333028 |
| 110 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.25426725 |
| 111 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.25055959 |
| 112 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.25029101 |
| 113 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.24837916 |
| 114 | Endocytosis_Homo sapiens_hsa04144 | 0.23126890 |
| 115 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.23100021 |
| 116 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.20822851 |
| 117 | Proteasome_Homo sapiens_hsa03050 | 0.20323055 |
| 118 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.20090875 |
| 119 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.19272559 |
| 120 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.16719967 |
| 121 | Colorectal cancer_Homo sapiens_hsa05210 | 0.16683939 |

