STMN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)6.81593515
2central nervous system myelination (GO:0022010)6.81593515
3nucleobase catabolic process (GO:0046113)5.06764859
4synaptic vesicle maturation (GO:0016188)4.88788928
5neuron cell-cell adhesion (GO:0007158)4.79233577
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.50143042
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.44634904
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.41380578
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.40565755
10synaptic vesicle exocytosis (GO:0016079)4.40046947
11vocalization behavior (GO:0071625)4.40043257
12protein localization to synapse (GO:0035418)4.32315935
13dendritic spine morphogenesis (GO:0060997)4.30662691
14behavioral response to nicotine (GO:0035095)4.25662429
15establishment of mitochondrion localization (GO:0051654)4.24934631
16layer formation in cerebral cortex (GO:0021819)4.12701043
17glutamate secretion (GO:0014047)4.12477373
18neuron recognition (GO:0008038)4.11328784
19locomotory exploration behavior (GO:0035641)4.07921164
20regulation of synaptic vesicle exocytosis (GO:2000300)4.06513340
21presynaptic membrane organization (GO:0097090)4.05252038
22long-chain fatty acid biosynthetic process (GO:0042759)3.98694203
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.89637976
24neurofilament cytoskeleton organization (GO:0060052)3.87696285
25neuronal action potential propagation (GO:0019227)3.86574014
26presynaptic membrane assembly (GO:0097105)3.86489870
27regulation of glutamate receptor signaling pathway (GO:1900449)3.81913188
28fatty acid elongation (GO:0030497)3.75617195
29myelination (GO:0042552)3.73009991
30ensheathment of neurons (GO:0007272)3.70156192
31axon ensheathment (GO:0008366)3.70156192
32regulation of neuronal synaptic plasticity (GO:0048168)3.65767080
33axonal fasciculation (GO:0007413)3.61762619
34negative regulation of neurotransmitter transport (GO:0051589)3.56910210
35glutamate receptor signaling pathway (GO:0007215)3.51947266
36dendrite morphogenesis (GO:0048813)3.48498876
37transmission of nerve impulse (GO:0019226)3.48134504
38regulation of synaptic vesicle transport (GO:1902803)3.47487348
39adult walking behavior (GO:0007628)3.46234270
40exploration behavior (GO:0035640)3.45631979
41regulation of synapse structural plasticity (GO:0051823)3.45630231
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.45575742
43gamma-aminobutyric acid transport (GO:0015812)3.45243540
44synaptic transmission, glutamatergic (GO:0035249)3.44842432
45cerebellar Purkinje cell differentiation (GO:0021702)3.42262828
46L-amino acid import (GO:0043092)3.39066420
47neuromuscular synaptic transmission (GO:0007274)3.38192618
48pyrimidine nucleobase catabolic process (GO:0006208)3.35322567
49glycine transport (GO:0015816)3.34684170
50neuron-neuron synaptic transmission (GO:0007270)3.34045769
51postsynaptic membrane organization (GO:0001941)3.28210991
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.26608849
53neurotransmitter secretion (GO:0007269)3.24093871
54regulation of dendritic spine morphogenesis (GO:0061001)3.22286482
55regulation of neurotransmitter levels (GO:0001505)3.21975629
56auditory behavior (GO:0031223)3.21914171
57membrane depolarization during action potential (GO:0086010)3.18349451
58negative regulation of axonogenesis (GO:0050771)3.17004451
59neurotransmitter-gated ion channel clustering (GO:0072578)3.15513418
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.15404081
61negative regulation of microtubule polymerization (GO:0031115)3.14559808
62neuronal ion channel clustering (GO:0045161)3.14401350
63positive regulation of synapse maturation (GO:0090129)3.14065529
64axon extension (GO:0048675)3.12856257
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.12270339
66cell migration in hindbrain (GO:0021535)3.11318655
67positive regulation of membrane potential (GO:0045838)3.10768724
68regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10588800
69negative regulation of neurotransmitter secretion (GO:0046929)3.09772245
70synapse organization (GO:0050808)3.09546133
71positive regulation of dendritic spine morphogenesis (GO:0061003)3.09200119
72cerebral cortex radially oriented cell migration (GO:0021799)3.08279942
73synaptic vesicle docking involved in exocytosis (GO:0016081)3.07910357
74cerebellar granule cell differentiation (GO:0021707)3.07094275
75adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.06499135
76mitochondrion transport along microtubule (GO:0047497)3.04335314
77establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04335314
78synaptic vesicle endocytosis (GO:0048488)3.04020090
79gamma-aminobutyric acid signaling pathway (GO:0007214)3.04006256
80long-term memory (GO:0007616)3.03734698
81cellular potassium ion homeostasis (GO:0030007)3.03665370
82membrane depolarization (GO:0051899)3.00555304
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.99977024
84negative regulation of protein localization to cell surface (GO:2000009)2.96857755
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96646032
86neurotransmitter transport (GO:0006836)2.95621842
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.94995017
88short-term memory (GO:0007614)2.94770727
89mechanosensory behavior (GO:0007638)2.94709657
90regulation of postsynaptic membrane potential (GO:0060078)2.94508392
91regulation of dendritic spine development (GO:0060998)2.93658914
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92753670
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92131952
94regulation of neurotransmitter transport (GO:0051588)2.91886633
95regulation of voltage-gated calcium channel activity (GO:1901385)2.91545134
96startle response (GO:0001964)2.91230206
97dendritic spine organization (GO:0097061)2.89877443
98regulation of synaptic plasticity (GO:0048167)2.89623880
99central nervous system projection neuron axonogenesis (GO:0021952)2.89479758
100organelle transport along microtubule (GO:0072384)2.86779565
101neuromuscular process controlling balance (GO:0050885)2.84374214
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83658200
103positive regulation of dendritic spine development (GO:0060999)2.82603471
104regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81837764
105response to auditory stimulus (GO:0010996)2.81035702
106behavioral fear response (GO:0001662)2.80648286
107behavioral defense response (GO:0002209)2.80648286
108regulation of neurotransmitter secretion (GO:0046928)2.79832336
109axon cargo transport (GO:0008088)2.79497592
110synapse assembly (GO:0007416)2.78183535
111regulation of collateral sprouting (GO:0048670)2.76867315
112neuron remodeling (GO:0016322)2.76866015
113adult behavior (GO:0030534)2.76433712
114neurotransmitter uptake (GO:0001504)2.76230653
115dendrite development (GO:0016358)2.74946507
116mating behavior (GO:0007617)2.74685642
117regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.74272691
118nerve growth factor signaling pathway (GO:0038180)2.73446389
119apical protein localization (GO:0045176)2.73228637
120membrane hyperpolarization (GO:0060081)2.73185316
121negative regulation of axon extension (GO:0030517)2.72820238
122long-term synaptic potentiation (GO:0060291)2.72446825
123learning (GO:0007612)2.71742467
124positive regulation of synapse assembly (GO:0051965)2.71183186
125oligodendrocyte differentiation (GO:0048709)2.70972260
126response to methylmercury (GO:0051597)2.70624552
127regulation of vesicle fusion (GO:0031338)2.70379280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.34575267
2GBX2_23144817_ChIP-Seq_PC3_Human3.47661421
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08440473
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02523780
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94061687
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.67856937
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.67856937
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.67056076
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55787678
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50009749
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49955405
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49514433
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49444167
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48975303
15REST_21632747_ChIP-Seq_MESCs_Mouse2.42303680
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.37476664
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36731510
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.29356101
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.22319762
20DROSHA_22980978_ChIP-Seq_HELA_Human2.21363522
21AR_21572438_ChIP-Seq_LNCaP_Human2.18002914
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.15791752
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.00182662
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99964247
25* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91470058
26TAF15_26573619_Chip-Seq_HEK293_Human1.90565824
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84443717
28RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79678009
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76930693
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76051216
31* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75081371
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74539973
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70188626
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68443171
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64144421
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.57124119
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57069307
38* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56146040
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54372984
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53294901
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45274391
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40277747
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.39641889
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39425508
45ERG_21242973_ChIP-ChIP_JURKAT_Human1.38705982
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38235307
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.37786307
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35205262
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33700362
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.31646450
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30827441
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.30691351
53P300_19829295_ChIP-Seq_ESCs_Human1.29072973
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23162863
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.21260756
56RNF2_27304074_Chip-Seq_NSC_Mouse1.20157620
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19816611
58VDR_22108803_ChIP-Seq_LS180_Human1.19654746
59IGF1R_20145208_ChIP-Seq_DFB_Human1.19551934
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.16761417
61DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16288252
62ER_23166858_ChIP-Seq_MCF-7_Human1.16196418
63ZNF274_21170338_ChIP-Seq_K562_Hela1.16187759
64* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14586388
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13187054
66STAT3_23295773_ChIP-Seq_U87_Human1.12518748
67* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12020043
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11075662
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.08896679
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.07892057
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07886474
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07323848
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06965543
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05781253
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05744026
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04113823
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03900252
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.01080802
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.00019935
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99956000
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99799545
82AR_25329375_ChIP-Seq_VCAP_Human0.99783503
83TCF4_23295773_ChIP-Seq_U87_Human0.99320843
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99045389
85CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98094707
86RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97816895
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97433097
88FUS_26573619_Chip-Seq_HEK293_Human0.95057449
89AHR_22903824_ChIP-Seq_MCF-7_Human0.94957480
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94740796
91* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94297275
92AR_19668381_ChIP-Seq_PC3_Human0.94022623
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93943047
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93454847
95* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92233029
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92069612
97* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91968127
98RUNX2_22187159_ChIP-Seq_PCA_Human0.90689058
99ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89989352
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88782052
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87447641
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86470948
103KDM2B_26808549_Chip-Seq_K562_Human0.86245977
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.86166361
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.85936220
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.85452487
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85452487
108SMAD3_21741376_ChIP-Seq_ESCs_Human0.84347423
109GATA1_26923725_Chip-Seq_HPCs_Mouse0.83669454
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83244259
111TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.83195082
112JUN_21703547_ChIP-Seq_K562_Human0.82288584
113CTCF_27219007_Chip-Seq_Bcells_Human0.82255800
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81968527
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.81764989
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.79184049

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.31335968
2MP0003880_abnormal_central_pattern4.99333065
3MP0004270_analgesia4.09022426
4MP0003635_abnormal_synaptic_transmissio3.61387471
5MP0005423_abnormal_somatic_nervous3.22315767
6MP0009745_abnormal_behavioral_response3.01198923
7MP0002064_seizures2.99772821
8MP0002063_abnormal_learning/memory/cond2.97349776
9MP0001486_abnormal_startle_reflex2.79768115
10MP0000920_abnormal_myelination2.77533653
11MP0002272_abnormal_nervous_system2.69581303
12MP0009046_muscle_twitch2.63309219
13MP0002734_abnormal_mechanical_nocicepti2.61763716
14MP0000778_abnormal_nervous_system2.58478555
15MP0002572_abnormal_emotion/affect_behav2.53467697
16MP0003329_amyloid_beta_deposits2.50379446
17MP0001968_abnormal_touch/_nociception2.36667985
18MP0001529_abnormal_vocalization2.25040562
19MP0004885_abnormal_endolymph2.11313079
20MP0001440_abnormal_grooming_behavior2.08551471
21MP0002822_catalepsy1.99801197
22MP0002733_abnormal_thermal_nociception1.99486254
23MP0001970_abnormal_pain_threshold1.95943187
24MP0003121_genomic_imprinting1.93618746
25MP0001905_abnormal_dopamine_level1.90993935
26MP0004142_abnormal_muscle_tone1.86947619
27MP0002735_abnormal_chemical_nociception1.83441221
28MP0000955_abnormal_spinal_cord1.81973436
29MP0002067_abnormal_sensory_capabilities1.78557003
30MP0002736_abnormal_nociception_after1.77754749
31MP0002184_abnormal_innervation1.77152254
32MP0008569_lethality_at_weaning1.76509543
33MP0005386_behavior/neurological_phenoty1.74745702
34MP0004924_abnormal_behavior1.74745702
35MP0004742_abnormal_vestibular_system1.74592135
36MP0003690_abnormal_glial_cell1.66660894
37MP0001501_abnormal_sleep_pattern1.64720287
38MP0002882_abnormal_neuron_morphology1.63458775
39MP0004811_abnormal_neuron_physiology1.62846748
40MP0002557_abnormal_social/conspecific_i1.61156224
41MP0003634_abnormal_glial_cell1.58965543
42MP0006276_abnormal_autonomic_nervous1.58261192
43MP0002066_abnormal_motor_capabilities/c1.53476052
44MP0009780_abnormal_chondrocyte_physiolo1.44826863
45MP0002638_abnormal_pupillary_reflex1.44563064
46MP0003633_abnormal_nervous_system1.41181622
47MP0002229_neurodegeneration1.40436968
48MP0003631_nervous_system_phenotype1.37946132
49MP0004858_abnormal_nervous_system1.33643983
50MP0005409_darkened_coat_color1.32417958
51MP0003632_abnormal_nervous_system1.28820054
52MP0005171_absent_coat_pigmentation1.26104567
53MP0001485_abnormal_pinna_reflex1.25537248
54MP0003123_paternal_imprinting1.23438481
55MP0008877_abnormal_DNA_methylation1.23165759
56MP0002152_abnormal_brain_morphology1.23005386
57MP0005645_abnormal_hypothalamus_physiol1.22895912
58MP0001984_abnormal_olfaction1.20095567
59MP0001502_abnormal_circadian_rhythm1.18748100
60MP0000604_amyloidosis1.17851036
61MP0005646_abnormal_pituitary_gland1.16260884
62MP0004133_heterotaxia1.06444576
63MP0002752_abnormal_somatic_nervous1.06324286
64MP0005551_abnormal_eye_electrophysiolog1.06037270
65MP0002653_abnormal_ependyma_morphology1.04965309
66MP0001963_abnormal_hearing_physiology1.03188702
67MP0003890_abnormal_embryonic-extraembry0.98229799
68MP0003122_maternal_imprinting0.96557639
69MP0004043_abnormal_pH_regulation0.95514354
70MP0003879_abnormal_hair_cell0.94934618
71MP0000569_abnormal_digit_pigmentation0.94656278
72MP0001188_hyperpigmentation0.93763859
73MP0000751_myopathy0.92288408
74MP0001177_atelectasis0.91463778
75MP0004145_abnormal_muscle_electrophysio0.90052899
76MP0005410_abnormal_fertilization0.89032144
77MP0000631_abnormal_neuroendocrine_gland0.88844705
78MP0003136_yellow_coat_color0.87518526
79MP0005623_abnormal_meninges_morphology0.87244135
80MP0002069_abnormal_eating/drinking_beha0.85041176
81MP0002909_abnormal_adrenal_gland0.84653945
82MP0000566_synostosis0.82219690
83MP0001348_abnormal_lacrimal_gland0.80769094
84MP0002751_abnormal_autonomic_nervous0.80749270
85MP0003950_abnormal_plasma_membrane0.80708648
86MP0010386_abnormal_urinary_bladder0.78441187
87MP0003861_abnormal_nervous_system0.76348447
88MP0001986_abnormal_taste_sensitivity0.75861014
89MP0003787_abnormal_imprinting0.75617639
90MP0001299_abnormal_eye_distance/0.75243316
91MP0003137_abnormal_impulse_conducting0.73734338
92MP0005253_abnormal_eye_physiology0.73134784
93MP0003938_abnormal_ear_development0.72037420
94MP0008789_abnormal_olfactory_epithelium0.71963861
95MP0003011_delayed_dark_adaptation0.71202525
96MP0004085_abnormal_heartbeat0.70495027
97MP0000026_abnormal_inner_ear0.69830214
98MP0000747_muscle_weakness0.69541488
99MP0008874_decreased_physiological_sensi0.65352021
100MP0006072_abnormal_retinal_apoptosis0.65204796
101MP0005499_abnormal_olfactory_system0.63546833
102MP0005394_taste/olfaction_phenotype0.63546833
103MP0000462_abnormal_digestive_system0.62348989
104MP0001943_abnormal_respiration0.61872299
105MP0005187_abnormal_penis_morphology0.61438611
106MP0002102_abnormal_ear_morphology0.60718497
107MP0005195_abnormal_posterior_eye0.60464887
108MP0008872_abnormal_physiological_respon0.59226648
109MP0002090_abnormal_vision0.58881802
110MP0008995_early_reproductive_senescence0.57785794
111MP0008260_abnormal_autophagy0.57512829
112MP0001664_abnormal_digestion0.57322188
113MP0002876_abnormal_thyroid_physiology0.57303408
114MP0003075_altered_response_to0.57260487
115MP0004130_abnormal_muscle_cell0.57226790
116MP0004147_increased_porphyrin_level0.55653726
117MP0006292_abnormal_olfactory_placode0.55367906
118MP0010768_mortality/aging0.55207607
119MP0000534_abnormal_ureter_morphology0.54828728
120MP0005535_abnormal_body_temperature0.54529988
121MP0010769_abnormal_survival0.54052947
122MP0002082_postnatal_lethality0.53692274
123MP0010770_preweaning_lethality0.53692274
124MP0004134_abnormal_chest_morphology0.53580151

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.08474733
2Neurofibrillary tangles (HP:0002185)5.21633181
3Focal motor seizures (HP:0011153)5.09789739
4Supranuclear gaze palsy (HP:0000605)4.63533359
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.54845837
6Degeneration of the lateral corticospinal tracts (HP:0002314)4.54845837
7Abnormality of the corticospinal tract (HP:0002492)4.52262131
8Cerebral inclusion bodies (HP:0100314)4.30614757
9Ankle clonus (HP:0011448)4.27336478
10Focal seizures (HP:0007359)4.16829411
11Spastic gait (HP:0002064)3.69681860
12Epileptic encephalopathy (HP:0200134)3.68417714
13Termporal pattern (HP:0011008)3.62963389
14Insidious onset (HP:0003587)3.62963389
15Peripheral hypomyelination (HP:0007182)3.46636193
16Visual hallucinations (HP:0002367)3.42855739
17Dysmetria (HP:0001310)3.38981021
18Limb dystonia (HP:0002451)3.38756062
19Broad-based gait (HP:0002136)3.24414518
20Mutism (HP:0002300)3.19461341
21Action tremor (HP:0002345)3.17830802
22Cortical dysplasia (HP:0002539)3.10589627
23Progressive cerebellar ataxia (HP:0002073)3.09514212
24Intention tremor (HP:0002080)3.02287173
25Failure to thrive in infancy (HP:0001531)3.01645922
26Cerebral hypomyelination (HP:0006808)2.98792915
27Urinary urgency (HP:0000012)2.98218030
28Atonic seizures (HP:0010819)2.97318133
29Onion bulb formation (HP:0003383)2.89727483
30Scanning speech (HP:0002168)2.89292138
31Megalencephaly (HP:0001355)2.89248027
32Agitation (HP:0000713)2.82120258
33Abnormality of the labia minora (HP:0012880)2.80827497
34Akinesia (HP:0002304)2.79446465
35Dialeptic seizures (HP:0011146)2.71239384
36Urinary bladder sphincter dysfunction (HP:0002839)2.67503771
37Lower limb muscle weakness (HP:0007340)2.66998427
38Absence seizures (HP:0002121)2.65243820
39Hyperventilation (HP:0002883)2.64341545
40Pheochromocytoma (HP:0002666)2.61804657
41Abnormal eating behavior (HP:0100738)2.60511801
42Lissencephaly (HP:0001339)2.59495140
43Generalized tonic-clonic seizures (HP:0002069)2.59466657
44Retinal dysplasia (HP:0007973)2.59151189
45Drooling (HP:0002307)2.57569498
46Excessive salivation (HP:0003781)2.57569498
47Sensory axonal neuropathy (HP:0003390)2.57416241
48Pachygyria (HP:0001302)2.57065107
49Anxiety (HP:0000739)2.54693737
50Poor eye contact (HP:0000817)2.54377347
51Spastic tetraplegia (HP:0002510)2.53330515
52Torticollis (HP:0000473)2.52958856
53Progressive inability to walk (HP:0002505)2.48895206
54Impaired vibration sensation in the lower limbs (HP:0002166)2.48738795
55Abnormality of the lower motor neuron (HP:0002366)2.48139247
56Poor suck (HP:0002033)2.46357967
57Dysdiadochokinesis (HP:0002075)2.45167557
58Ulnar claw (HP:0001178)2.40485543
59Polyphagia (HP:0002591)2.37658346
60Truncal ataxia (HP:0002078)2.35065177
61Hemiparesis (HP:0001269)2.34892966
62Depression (HP:0000716)2.34695338
63Clonus (HP:0002169)2.31595060
64Alacrima (HP:0000522)2.30837254
65Morphological abnormality of the pyramidal tract (HP:0002062)2.29563236
66Focal dystonia (HP:0004373)2.29550421
67Status epilepticus (HP:0002133)2.28557476
68Abnormality of binocular vision (HP:0011514)2.25438633
69Diplopia (HP:0000651)2.25438633
70Febrile seizures (HP:0002373)2.24092352
71Neuroendocrine neoplasm (HP:0100634)2.22401217
72Hypoplasia of the corpus callosum (HP:0002079)2.21542380
73Fetal akinesia sequence (HP:0001989)2.21463205
74Postural instability (HP:0002172)2.21310651
75Gaze-evoked nystagmus (HP:0000640)2.20803734
76Genetic anticipation (HP:0003743)2.20700733
77Abnormal social behavior (HP:0012433)2.19813466
78Impaired social interactions (HP:0000735)2.19813466
79Amyotrophic lateral sclerosis (HP:0007354)2.18475653
80Parakeratosis (HP:0001036)2.16683375
81Amblyopia (HP:0000646)2.15789938
82Craniofacial dystonia (HP:0012179)2.15450016
83Esotropia (HP:0000565)2.15276771
84Generalized myoclonic seizures (HP:0002123)2.13904628
85Thickened helices (HP:0000391)2.12458974
86Nephrogenic diabetes insipidus (HP:0009806)2.10783720
87Abnormal auditory evoked potentials (HP:0006958)2.10205725
88Neuronal loss in central nervous system (HP:0002529)2.09627506
89Leukodystrophy (HP:0002415)2.07682040
90CNS hypomyelination (HP:0003429)2.06193235
91Slow saccadic eye movements (HP:0000514)2.05537728
92Congenital primary aphakia (HP:0007707)2.04980530
93Spastic tetraparesis (HP:0001285)2.04351466
94Epileptiform EEG discharges (HP:0011182)2.04165716
95Medial flaring of the eyebrow (HP:0010747)2.03473117
96EEG with generalized epileptiform discharges (HP:0011198)2.00091221
97Papilledema (HP:0001085)1.99752051
98Aplasia involving bones of the extremities (HP:0009825)1.99098107
99Aplasia involving bones of the upper limbs (HP:0009823)1.99098107
100Aplasia of the phalanges of the hand (HP:0009802)1.99098107
101Clumsiness (HP:0002312)1.98545095
102Specific learning disability (HP:0001328)1.97569411
103Hypsarrhythmia (HP:0002521)1.97088189
104Hemiplegia (HP:0002301)1.96776863
105Hypoplasia of the brainstem (HP:0002365)1.96425834
106Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96425834
107Absent speech (HP:0001344)1.94338372
108Poor speech (HP:0002465)1.93274761
109Blue irides (HP:0000635)1.92670963
110Delusions (HP:0000746)1.92352055
111Oligomenorrhea (HP:0000876)1.90330394
112Sleep apnea (HP:0010535)1.90228989
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.88415937
114Hammertoe (HP:0001765)1.86474595
115Gait imbalance (HP:0002141)1.85894231
116Incomplete penetrance (HP:0003829)1.85075798
117Bowel incontinence (HP:0002607)1.84373277
118Abnormality of salivation (HP:0100755)1.84075714
119Vaginal atresia (HP:0000148)1.82347802
120Stereotypic behavior (HP:0000733)1.81753705
121Inability to walk (HP:0002540)1.81697999
122Muscular hypotonia of the trunk (HP:0008936)1.81389764
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81313733
124Abnormal hair whorl (HP:0010721)1.80243840
125Genital tract atresia (HP:0001827)1.80112964
126Paraplegia (HP:0010550)1.79818897
127Impaired vibratory sensation (HP:0002495)1.73222692
128Hypoventilation (HP:0002791)1.71990451
129Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71479137
130Abnormality of alanine metabolism (HP:0010916)1.71479137
131Hyperalaninemia (HP:0003348)1.71479137
132Polymicrogyria (HP:0002126)1.71235242
133Myotonia (HP:0002486)1.70840660
134Intellectual disability, severe (HP:0010864)1.70540753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.40618304
2EPHA43.03277813
3STK392.83751088
4MAP3K92.80772131
5NTRK32.76454673
6OXSR12.58316397
7CASK2.35110729
8CDK192.23574506
9PAK62.15716196
10UHMK12.03704223
11NTRK22.03446972
12PKN12.01163227
13MINK11.99536015
14PNCK1.98289356
15MAP3K41.96676367
16DAPK21.79262923
17NTRK11.75707032
18BCR1.69425980
19MAP2K71.67563155
20DYRK21.60221954
21MAPK131.58260686
22PHKG21.56483070
23PHKG11.56483070
24LIMK11.54596060
25CDK51.54016128
26TNIK1.51753542
27FGFR21.50088375
28KSR21.43034743
29CSNK1G21.42117557
30CAMK2B1.40652982
31MAPKAPK51.40574725
32PRPF4B1.36559598
33CSNK1G31.30241725
34TYRO31.28605909
35PRKD31.22875821
36SGK4941.21074652
37SGK2231.21074652
38CSNK1A1L1.16804242
39MARK21.15267986
40TRIM281.14806351
41CDK141.13842458
42CDK151.11039284
43CDK181.10412840
44KSR11.10085433
45PLK21.09572724
46WNK41.07529385
47CAMK2A1.07393343
48EPHB11.06130101
49PAK31.01080667
50DYRK1B1.00073531
51CDK11A0.98738262
52FGR0.98237341
53MAP2K40.97885728
54EPHA30.97864931
55ROCK20.96161862
56SGK20.95066636
57GRK50.93023570
58ARAF0.92286180
59MAP4K20.90734225
60NEK60.89292381
61WNK10.89258746
62SIK20.88854425
63CAMK2D0.88715585
64CAMKK10.88198426
65PRKCG0.87014452
66CSNK1G10.85807756
67DYRK30.83364036
68TESK20.81836566
69EPHB20.80905486
70MAP3K120.80429003
71STK110.80332042
72MAP3K110.78923279
73DYRK1A0.77272672
74CAMK2G0.77255634
75ICK0.75787895
76MAP3K20.72824597
77PRKCE0.71749590
78ERBB30.69755276
79FES0.66732023
80DAPK30.64911415
81MET0.62673153
82FYN0.60865261
83PDPK10.57946128
84WNK30.57288345
85RPS6KA20.56641100
86PRKCZ0.56466978
87PRKCH0.56390805
88RIPK40.56249567
89RET0.55351035
90LATS20.53807387
91DAPK10.53745087
92CAMK10.53709489
93CAMK40.53420266
94MUSK0.52584719
95MAPK150.51821254
96PTK2B0.49130908
97SGK30.48854936
98CAMK1G0.48808070
99ADRBK20.46854840
100PRKD10.46632811
101SGK10.45964186
102CAMKK20.45943782
103PINK10.45842839
104PRKACA0.45557180
105CLK10.45274873
106CSNK1A10.44164657
107CSNK1E0.43393691
108PDK10.41661252
109ALK0.39909643
110PRKG10.39808216
111MAPK120.39644367
112NME10.39306746
113BMPR1B0.37753550
114PRKAA10.36566669
115RPS6KA40.36510525
116MAP3K130.36071103
117SIK30.35558047
118CSNK1D0.35122123
119ERBB20.34534910
120RPS6KA30.33662502
121PRKCQ0.33198118
122MAPK80.33085686
123MAPK100.31172756
124PRKCA0.30628986
125STK380.29609076
126MAPK90.28329794
127ADRBK10.27412727
128MAPK40.27281054

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.12104331
2Synaptic vesicle cycle_Homo sapiens_hsa047212.83538079
3GABAergic synapse_Homo sapiens_hsa047272.67333988
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.52507420
5Glutamatergic synapse_Homo sapiens_hsa047242.51745456
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45410556
7Circadian entrainment_Homo sapiens_hsa047132.36393711
8Morphine addiction_Homo sapiens_hsa050322.35322668
9Olfactory transduction_Homo sapiens_hsa047402.16203821
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06781324
11Dopaminergic synapse_Homo sapiens_hsa047282.00738148
12Axon guidance_Homo sapiens_hsa043602.00560106
13Long-term potentiation_Homo sapiens_hsa047201.98996271
14Amphetamine addiction_Homo sapiens_hsa050311.94543258
15Serotonergic synapse_Homo sapiens_hsa047261.84177517
16Salivary secretion_Homo sapiens_hsa049701.80343877
17Cocaine addiction_Homo sapiens_hsa050301.79061128
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77340597
19Cholinergic synapse_Homo sapiens_hsa047251.75291025
20Long-term depression_Homo sapiens_hsa047301.73124801
21Gastric acid secretion_Homo sapiens_hsa049711.66073601
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62455377
23Steroid biosynthesis_Homo sapiens_hsa001001.61037339
24Collecting duct acid secretion_Homo sapiens_hsa049661.52415894
25Fatty acid elongation_Homo sapiens_hsa000621.50063776
26Insulin secretion_Homo sapiens_hsa049111.46463860
27Renin secretion_Homo sapiens_hsa049241.45645447
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43488038
29Taste transduction_Homo sapiens_hsa047421.41890661
30Gap junction_Homo sapiens_hsa045401.41018133
31Nitrogen metabolism_Homo sapiens_hsa009101.31793408
32Oxytocin signaling pathway_Homo sapiens_hsa049211.31764827
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29234550
34Ether lipid metabolism_Homo sapiens_hsa005651.28826909
35Vibrio cholerae infection_Homo sapiens_hsa051101.19092073
36Calcium signaling pathway_Homo sapiens_hsa040201.14620097
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13624918
38Cardiac muscle contraction_Homo sapiens_hsa042601.11728075
39GnRH signaling pathway_Homo sapiens_hsa049121.11102456
40ErbB signaling pathway_Homo sapiens_hsa040121.11024525
41Oxidative phosphorylation_Homo sapiens_hsa001901.10258427
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08955798
43Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.05951232
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04503518
45cAMP signaling pathway_Homo sapiens_hsa040241.03115951
46Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03092566
47Alzheimers disease_Homo sapiens_hsa050101.01850585
48Renal cell carcinoma_Homo sapiens_hsa052110.98492610
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.98158759
50Phototransduction_Homo sapiens_hsa047440.95058729
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94927650
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.94086758
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91577743
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.91425838
55Melanogenesis_Homo sapiens_hsa049160.90648640
56Parkinsons disease_Homo sapiens_hsa050120.89558891
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.89059933
58Estrogen signaling pathway_Homo sapiens_hsa049150.87359140
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.87264939
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85800130
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85685785
62Ras signaling pathway_Homo sapiens_hsa040140.81178717
63Butanoate metabolism_Homo sapiens_hsa006500.80938743
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79757574
65Regulation of autophagy_Homo sapiens_hsa041400.79082474
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78773804
67Dorso-ventral axis formation_Homo sapiens_hsa043200.77814805
68Glioma_Homo sapiens_hsa052140.77144586
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74885717
70Endocytosis_Homo sapiens_hsa041440.73312341
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72292939
72Type II diabetes mellitus_Homo sapiens_hsa049300.69209296
73Pancreatic secretion_Homo sapiens_hsa049720.68925957
74Choline metabolism in cancer_Homo sapiens_hsa052310.68664398
75MAPK signaling pathway_Homo sapiens_hsa040100.66751828
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65958206
77Alcoholism_Homo sapiens_hsa050340.63508987
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58664285
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56383281
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53485527
81Tight junction_Homo sapiens_hsa045300.53253126
82Oocyte meiosis_Homo sapiens_hsa041140.52268051
83Bile secretion_Homo sapiens_hsa049760.52117006
84Sphingolipid metabolism_Homo sapiens_hsa006000.51865482
85Dilated cardiomyopathy_Homo sapiens_hsa054140.50083498
86VEGF signaling pathway_Homo sapiens_hsa043700.49442571
87Prion diseases_Homo sapiens_hsa050200.49166371
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47638149
89Rap1 signaling pathway_Homo sapiens_hsa040150.47296217
90Ovarian steroidogenesis_Homo sapiens_hsa049130.47095130
91Huntingtons disease_Homo sapiens_hsa050160.44101743
92Thyroid hormone synthesis_Homo sapiens_hsa049180.43804173
93Vitamin B6 metabolism_Homo sapiens_hsa007500.43252176
94Wnt signaling pathway_Homo sapiens_hsa043100.42787675
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.41560324
96Hippo signaling pathway_Homo sapiens_hsa043900.41466708
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40875265
98Phagosome_Homo sapiens_hsa041450.40671357
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40478161
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39210034
101Arginine and proline metabolism_Homo sapiens_hsa003300.37866319
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.37601354
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37520390
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35489929
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35021923
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34357057
107Hedgehog signaling pathway_Homo sapiens_hsa043400.33876803
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.33409679
109Rheumatoid arthritis_Homo sapiens_hsa053230.32991138
110Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32271291
111Circadian rhythm_Homo sapiens_hsa047100.31825595
112Chemokine signaling pathway_Homo sapiens_hsa040620.31811718
113AMPK signaling pathway_Homo sapiens_hsa041520.31562218
114Linoleic acid metabolism_Homo sapiens_hsa005910.29792217
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29443502
116Histidine metabolism_Homo sapiens_hsa003400.29271123
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27178385

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