STOML1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)9.80837718
2daunorubicin metabolic process (GO:0044597)9.80837718
3polyketide metabolic process (GO:0030638)9.80837718
4maintenance of protein location in nucleus (GO:0051457)6.36727966
5aminoglycoside antibiotic metabolic process (GO:0030647)6.20675422
6regulation of mammary gland epithelial cell proliferation (GO:0033599)5.73600281
7proline transport (GO:0015824)5.64939456
8regulation of MHC class I biosynthetic process (GO:0045343)5.54177758
9histone H4-K8 acetylation (GO:0043982)5.50017563
10histone H4-K5 acetylation (GO:0043981)5.50017563
11somite rostral/caudal axis specification (GO:0032525)5.47245026
12regulation of response to osmotic stress (GO:0047484)5.46304890
13negative regulation of telomerase activity (GO:0051974)5.44065556
14histone H4-K12 acetylation (GO:0043983)5.16077756
15synaptic vesicle maturation (GO:0016188)5.13649657
16negative regulation of epidermis development (GO:0045683)5.05565227
17negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.76883476
18detection of temperature stimulus (GO:0016048)4.68065191
19regulation of telomere maintenance via telomerase (GO:0032210)4.66791950
20regulation of cilium movement (GO:0003352)4.64941481
21response to dietary excess (GO:0002021)4.52123157
22negative regulation of synaptic transmission, GABAergic (GO:0032229)4.47882578
23behavioral response to nicotine (GO:0035095)4.46724700
24muscle organ morphogenesis (GO:0048644)4.34601480
25negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.31223423
26phenol-containing compound catabolic process (GO:0019336)4.28032756
27gamma-aminobutyric acid transport (GO:0015812)4.22213778
28negative regulation of cell cycle G2/M phase transition (GO:1902750)4.17666412
29DNA deamination (GO:0045006)4.17121862
30rRNA transcription (GO:0009303)4.16552089
31calcium-mediated signaling using intracellular calcium source (GO:0035584)4.14890698
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13931036
33regulation of nuclear cell cycle DNA replication (GO:0033262)4.09689827
34histone H4-K16 acetylation (GO:0043984)4.08968196
35response to pheromone (GO:0019236)3.91867440
36cytidine deamination (GO:0009972)3.91445043
37cytidine metabolic process (GO:0046087)3.91445043
38cytidine catabolic process (GO:0006216)3.91445043
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.86377550
40mitochondrion distribution (GO:0048311)3.86333740
41protein polyglutamylation (GO:0018095)3.85263328
42nucleoside transmembrane transport (GO:1901642)3.79225762
43microtubule severing (GO:0051013)3.71720976
44regulation of telomerase activity (GO:0051972)3.61538018
45cell migration in hindbrain (GO:0021535)3.57719663
46interferon-gamma production (GO:0032609)3.57326856
47regulation of microtubule-based movement (GO:0060632)3.54514978
48neuronal action potential propagation (GO:0019227)3.54053005
49protein localization to kinetochore (GO:0034501)3.51965490
50negative regulation of epidermal cell differentiation (GO:0045605)3.51630921
51negative regulation of telomere maintenance (GO:0032205)3.48285218
52quinone metabolic process (GO:1901661)3.43785950
53glutamate secretion (GO:0014047)3.40535336
54pyrimidine nucleobase catabolic process (GO:0006208)3.39818555
55branching involved in mammary gland duct morphogenesis (GO:0060444)3.39374527
56maintenance of protein localization in organelle (GO:0072595)3.37535395
57synaptic vesicle docking involved in exocytosis (GO:0016081)3.37483250
58cardiovascular system development (GO:0072358)3.34725472
59cellular ketone body metabolic process (GO:0046950)3.31363634
60regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.29560459
61coenzyme catabolic process (GO:0009109)3.28610437
62cell fate commitment involved in formation of primary germ layer (GO:0060795)3.26058619
63tachykinin receptor signaling pathway (GO:0007217)3.24488506
64mitotic sister chromatid segregation (GO:0000070)3.24244258
65postsynaptic membrane organization (GO:0001941)3.22761505
66membrane depolarization during action potential (GO:0086010)3.21177675
67rRNA methylation (GO:0031167)3.20574501
68primitive streak formation (GO:0090009)3.20016184
69notochord development (GO:0030903)3.17058334
70primary amino compound metabolic process (GO:1901160)3.16279133
71synaptic transmission, glutamatergic (GO:0035249)3.16077043
72fucose catabolic process (GO:0019317)3.15839773
73L-fucose metabolic process (GO:0042354)3.15839773
74L-fucose catabolic process (GO:0042355)3.15839773
75negative regulation of potassium ion transmembrane transport (GO:1901380)3.15149029
76retinal cone cell development (GO:0046549)3.14029667
77cullin deneddylation (GO:0010388)3.10436723
78arachidonic acid secretion (GO:0050482)3.09911830
79icosanoid secretion (GO:0032309)3.09911830
80heterochromatin organization (GO:0070828)3.07960386
81regulation of synapse structural plasticity (GO:0051823)3.07261978
82melanosome transport (GO:0032402)3.06836829
83ventricular system development (GO:0021591)3.06576677
84dendritic spine morphogenesis (GO:0060997)3.06458932
85regulation of translation in response to stress (GO:0043555)3.05771547
86ionotropic glutamate receptor signaling pathway (GO:0035235)3.04976183
87serotonin metabolic process (GO:0042428)3.04015348
88kynurenine metabolic process (GO:0070189)3.04008160
89nucleobase catabolic process (GO:0046113)3.00306985
90ketone body metabolic process (GO:1902224)3.00097853
91hormone catabolic process (GO:0042447)2.99853854
92glutamate receptor signaling pathway (GO:0007215)2.99669108
93regulation of telomere maintenance (GO:0032204)2.99428423
94G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98064010
95establishment of melanosome localization (GO:0032401)2.96613314
96detection of temperature stimulus involved in sensory perception (GO:0050961)2.96438251
97detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.96438251
98neuronal action potential (GO:0019228)2.95514929
99pyrimidine ribonucleoside catabolic process (GO:0046133)2.94242593
100detection of light stimulus involved in sensory perception (GO:0050962)2.93709398
101detection of light stimulus involved in visual perception (GO:0050908)2.93709398
102positive regulation of DNA-dependent DNA replication (GO:2000105)2.93199136
103regulation of apoptotic process involved in morphogenesis (GO:1902337)2.92372817
104regulation of short-term neuronal synaptic plasticity (GO:0048172)2.90381800
105pigment granule transport (GO:0051904)2.88099077
106tryptophan catabolic process (GO:0006569)2.87977850
107indole-containing compound catabolic process (GO:0042436)2.87977850
108indolalkylamine catabolic process (GO:0046218)2.87977850
109retinoic acid receptor signaling pathway (GO:0048384)2.87781169
110detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86944257
111transmission of nerve impulse (GO:0019226)2.86822302
112DNA damage response, detection of DNA damage (GO:0042769)2.86564547
113startle response (GO:0001964)2.86448375
114pre-miRNA processing (GO:0031054)2.85971368
115intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.85734841
116cellular response to ATP (GO:0071318)2.85049598
117positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.82686750
118positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.82236443
119indolalkylamine metabolic process (GO:0006586)2.80926357
120glycosphingolipid biosynthetic process (GO:0006688)2.80694578
121synaptic vesicle exocytosis (GO:0016079)2.80291313
122negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.80096134
123positive regulation of muscle cell apoptotic process (GO:0010661)2.79837969
124neurotransmitter secretion (GO:0007269)2.79726101
125establishment of pigment granule localization (GO:0051905)2.79191983
126indole-containing compound metabolic process (GO:0042430)2.79005645
127mitochondrion localization (GO:0051646)2.78845258
128regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.78229903
129vitamin A metabolic process (GO:0006776)2.78118203
130protein localization to cilium (GO:0061512)2.77716977
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.76071334
132mitochondrion transport along microtubule (GO:0047497)2.76071334
133vocalization behavior (GO:0071625)2.74472881
134negative regulation of mast cell activation (GO:0033004)2.74208184
135regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.73738943
136GDP-mannose metabolic process (GO:0019673)2.72526848
137adaptation of signaling pathway (GO:0023058)2.70985139
138positive regulation of protein deacetylation (GO:0090312)2.70725152
139negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.70656038
140regulation of action potential (GO:0098900)2.69451710
141establishment of mitochondrion localization (GO:0051654)2.69425018
142neuron cell-cell adhesion (GO:0007158)2.69232082
143alanine transport (GO:0032328)2.68900839
144nucleoside transport (GO:0015858)2.68405175
145protein deneddylation (GO:0000338)2.68126793
146protein localization to synapse (GO:0035418)2.67808241
147regulation of vacuole organization (GO:0044088)2.67587284
148neuron-neuron synaptic transmission (GO:0007270)2.65478635
149behavioral response to ethanol (GO:0048149)2.63948080
150response to gravity (GO:0009629)2.63485950
151platelet dense granule organization (GO:0060155)2.63485322
152neuromuscular synaptic transmission (GO:0007274)2.62265621
153regulation of neurotransmitter uptake (GO:0051580)2.61704218
154C4-dicarboxylate transport (GO:0015740)2.61527334
155protein complex biogenesis (GO:0070271)2.60451150
156regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60030949
157positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.59743625
158auditory receptor cell stereocilium organization (GO:0060088)2.59741686
159auditory behavior (GO:0031223)2.59632871
160preassembly of GPI anchor in ER membrane (GO:0016254)2.58679448
161cAMP catabolic process (GO:0006198)2.57775014
162regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56037872
163mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54811273
164mitochondrial respiratory chain complex I assembly (GO:0032981)2.54811273
165NADH dehydrogenase complex assembly (GO:0010257)2.54811273
166negative regulation of cytosolic calcium ion concentration (GO:0051481)2.54738544
167tryptophan metabolic process (GO:0006568)2.54218472
168membrane depolarization (GO:0051899)2.54084360
169protein import into peroxisome matrix (GO:0016558)2.51407919
170cyclic nucleotide catabolic process (GO:0009214)2.49648753
171regulation of voltage-gated calcium channel activity (GO:1901385)2.48761191
172gamma-aminobutyric acid signaling pathway (GO:0007214)2.48278559
173regulation of neurotransmitter levels (GO:0001505)2.44148829
174respiratory chain complex IV assembly (GO:0008535)2.43123757
175sleep (GO:0030431)2.39791602
176response to amphetamine (GO:0001975)2.38838880
177regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.37400147
178potassium ion transmembrane transport (GO:0071805)2.37037505
179cellular potassium ion transport (GO:0071804)2.37037505
180positive regulation of mitochondrial fission (GO:0090141)2.36684877
181water-soluble vitamin biosynthetic process (GO:0042364)2.36624937
182regulation of mitochondrial fission (GO:0090140)2.35236836
183glycerophospholipid catabolic process (GO:0046475)2.34797578
184mitochondrial respiratory chain complex assembly (GO:0033108)2.34744142
185synaptic transmission, cholinergic (GO:0007271)2.33370566
186regulation of excitatory postsynaptic membrane potential (GO:0060079)2.33151715
187positive regulation of meiosis (GO:0045836)2.33131276
188synaptic transmission (GO:0007268)2.33129935
189piRNA metabolic process (GO:0034587)2.33026555
190axoneme assembly (GO:0035082)2.32411130

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.93704708
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.93704708
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.93704708
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.64675103
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.72943696
6ZNF274_21170338_ChIP-Seq_K562_Hela3.48191560
7* NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.35106903
8GBX2_23144817_ChIP-Seq_PC3_Human3.26840936
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.11170751
10SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.89913458
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.63499350
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.62549513
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.56153658
14VDR_22108803_ChIP-Seq_LS180_Human2.52593568
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.43482426
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.41703864
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37477893
18ZFP281_18757296_ChIP-ChIP_E14_Mouse2.26367336
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.25727010
20NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.11207323
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08735488
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08284609
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04512496
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00255051
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99209120
26SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.96009918
27NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.94908474
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.94820778
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.84213829
30NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.81069067
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75293620
32TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.75030310
33EZH2_22144423_ChIP-Seq_EOC_Human1.72526877
34DROSHA_22980978_ChIP-Seq_HELA_Human1.70629390
35ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68321433
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.65621905
37* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.61321038
38REST_21632747_ChIP-Seq_MESCs_Mouse1.61149123
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.60998529
40RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.58420787
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.57744054
42* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.55177588
43TAF15_26573619_Chip-Seq_HEK293_Human1.54935093
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53153478
45PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.52732854
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52573750
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.52366578
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.51400153
49P300_19829295_ChIP-Seq_ESCs_Human1.49289639
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47675209
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.45586931
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.45522361
53EED_16625203_ChIP-ChIP_MESCs_Mouse1.42818932
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42053623
55* E2F1_17053090_ChIP-ChIP_MCF-7_Human1.41198705
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41169688
57TP53_22573176_ChIP-Seq_HFKS_Human1.41110548
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40759890
59RNF2_27304074_Chip-Seq_NSC_Mouse1.40335055
60LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39932298
61* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39823541
62BCAT_22108803_ChIP-Seq_LS180_Human1.39758009
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38345174
64RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37762235
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37762235
66WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37614714
67KDM2B_26808549_Chip-Seq_K562_Human1.35659728
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35558807
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34806247
70STAT3_23295773_ChIP-Seq_U87_Human1.34524309
71SMAD4_21799915_ChIP-Seq_A2780_Human1.34198063
72ER_23166858_ChIP-Seq_MCF-7_Human1.33654009
73* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.31635705
74SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30664673
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.30441399
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.29253841
77TCF4_23295773_ChIP-Seq_U87_Human1.28018161
78* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.27820409
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27624463
80IRF1_19129219_ChIP-ChIP_H3396_Human1.27612970
81* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26793926
82AR_25329375_ChIP-Seq_VCAP_Human1.26582856
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.24472189
84PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24445342
85YY1_21170310_ChIP-Seq_MESCs_Mouse1.22803268
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22249962
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.22211102
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21650340
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.21313256
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21226491
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20406407
92AR_21572438_ChIP-Seq_LNCaP_Human1.19639099
93CDX2_20551321_ChIP-Seq_CACO-2_Human1.16909943
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16798616
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16254911
96* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15266778
97TP53_20018659_ChIP-ChIP_R1E_Mouse1.14536230
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13701373
99TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.13166851
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12626238
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.12424729
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12167497
103NCOR_22424771_ChIP-Seq_293T_Human1.11255614
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11127695
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.10772602
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.10764379
107FUS_26573619_Chip-Seq_HEK293_Human1.10637029
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09990624
109* NANOG_16518401_ChIP-PET_MESCs_Mouse1.09676890
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09548938
111CBP_20019798_ChIP-Seq_JUKART_Human1.09528680
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09528680
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09049903
114STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09049457
115THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08517028
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.07063645
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06960624
118PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06785508
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05971210
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05971210
121MYC_19829295_ChIP-Seq_ESCs_Human1.04977828
122TAF2_19829295_ChIP-Seq_ESCs_Human1.04326698
123PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03683377
124SOX2_19829295_ChIP-Seq_ESCs_Human1.03195159
125NANOG_19829295_ChIP-Seq_ESCs_Human1.03195159
126ERA_21632823_ChIP-Seq_H3396_Human1.02449335
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02221425
128IGF1R_20145208_ChIP-Seq_DFB_Human1.02055994
129* SMC4_20622854_ChIP-Seq_HELA_Human1.01961722
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01808964
131FOXA1_25329375_ChIP-Seq_VCAP_Human1.01477387
132FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01477387
133SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01324007
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.01159133
135STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00971169
136MYC_22102868_ChIP-Seq_BL_Human1.00708461
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00652127
138KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00561668
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99314964
140STAT3_18555785_ChIP-Seq_MESCs_Mouse0.99252355
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99080962
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.98843417
143CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98777983
144RUNX2_22187159_ChIP-Seq_PCA_Human0.98435760
145SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98400481
146EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97948980
147GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97925409
148CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97531310
149ELK4_26923725_Chip-Seq_MESODERM_Mouse0.96690599
150EWS_26573619_Chip-Seq_HEK293_Human0.96080930
151FLI1_21867929_ChIP-Seq_TH2_Mouse0.95758716
152TBX3_20139965_ChIP-Seq_ESCs_Mouse0.95698797
153POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95340004
154BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94960015
155HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94921335
156DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94863447
157SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94848735
158TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94829942
159BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94705115
160SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94557660
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94478207
162OCT4_20526341_ChIP-Seq_ESCs_Human0.94299644
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93894430
164CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93787436
165EZH2_27304074_Chip-Seq_ESCs_Mouse0.93171263
166STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92555259
167TP53_22127205_ChIP-Seq_IMR90_Human0.92161912
168NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91685258
169NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90679512
170SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.87585377
171RING1B_27294783_Chip-Seq_ESCs_Mouse0.87537309
172SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87515904
173SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84781141
174* LXR_22292898_ChIP-Seq_THP-1_Human0.83646294
175SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82961413

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system4.61748641
2MP0002254_reproductive_system_inflammat4.10452833
3MP0006292_abnormal_olfactory_placode3.81373582
4MP0005394_taste/olfaction_phenotype3.76963599
5MP0005499_abnormal_olfactory_system3.76963599
6MP0003122_maternal_imprinting3.37091735
7MP0004859_abnormal_synaptic_plasticity3.08309969
8MP0003011_delayed_dark_adaptation2.95239663
9MP0004264_abnormal_extraembryonic_tissu2.90593933
10MP0003890_abnormal_embryonic-extraembry2.70673987
11MP0004270_analgesia2.56633618
12MP0002653_abnormal_ependyma_morphology2.55753681
13MP0005075_abnormal_melanosome_morpholog2.44767402
14MP0002332_abnormal_exercise_endurance2.42194128
15MP0001348_abnormal_lacrimal_gland2.33394548
16MP0003121_genomic_imprinting2.16643071
17MP0002876_abnormal_thyroid_physiology2.16351327
18MP0002837_dystrophic_cardiac_calcinosis2.14632809
19MP0008961_abnormal_basal_metabolism2.12230563
20MP0001986_abnormal_taste_sensitivity2.11582682
21MP0005551_abnormal_eye_electrophysiolog2.09361675
22MP0003880_abnormal_central_pattern2.03634107
23MP0004885_abnormal_endolymph1.99877167
24MP0002735_abnormal_chemical_nociception1.96923357
25MP0003635_abnormal_synaptic_transmissio1.96416793
26MP0002733_abnormal_thermal_nociception1.91369663
27MP0006035_abnormal_mitochondrial_morpho1.88620319
28MP0003183_abnormal_peptide_metabolism1.87200978
29MP0002734_abnormal_mechanical_nocicepti1.86865422
30MP0001968_abnormal_touch/_nociception1.86410769
31MP0005646_abnormal_pituitary_gland1.85886772
32MP0008789_abnormal_olfactory_epithelium1.80860400
33MP0003646_muscle_fatigue1.78822973
34MP0003195_calcinosis1.77875590
35MP0009046_muscle_twitch1.77753596
36MP0008877_abnormal_DNA_methylation1.77217882
37MP0002102_abnormal_ear_morphology1.76504155
38MP0002572_abnormal_emotion/affect_behav1.75403167
39MP0002063_abnormal_learning/memory/cond1.73978845
40MP0000569_abnormal_digit_pigmentation1.73924650
41MP0004147_increased_porphyrin_level1.73341588
42MP0000678_abnormal_parathyroid_gland1.67435481
43MP0002184_abnormal_innervation1.65033213
44MP0002064_seizures1.62992058
45MP0003787_abnormal_imprinting1.60875394
46MP0003938_abnormal_ear_development1.59467625
47MP0005645_abnormal_hypothalamus_physiol1.58060525
48MP0002638_abnormal_pupillary_reflex1.56914656
49MP0004043_abnormal_pH_regulation1.56229864
50MP0002277_abnormal_respiratory_mucosa1.55591992
51MP0000955_abnormal_spinal_cord1.55574055
52MP0008057_abnormal_DNA_replication1.54643628
53MP0001970_abnormal_pain_threshold1.54018462
54MP0005257_abnormal_intraocular_pressure1.53860802
55MP0008875_abnormal_xenobiotic_pharmacok1.53634889
56MP0002736_abnormal_nociception_after1.50169939
57MP0004924_abnormal_behavior1.49944437
58MP0005386_behavior/neurological_phenoty1.49944437
59MP0000778_abnormal_nervous_system1.49450885
60MP0001486_abnormal_startle_reflex1.43392001
61MP0009745_abnormal_behavioral_response1.39958256
62MP0003879_abnormal_hair_cell1.39895393
63MP0006276_abnormal_autonomic_nervous1.35371603
64MP0004145_abnormal_muscle_electrophysio1.34601923
65MP0002751_abnormal_autonomic_nervous1.34396585
66MP0004133_heterotaxia1.33731777
67MP0005253_abnormal_eye_physiology1.33711147
68MP0004742_abnormal_vestibular_system1.32500404
69MP0002909_abnormal_adrenal_gland1.28320548
70MP0002272_abnormal_nervous_system1.28052906
71MP0004130_abnormal_muscle_cell1.27976063
72MP0001502_abnormal_circadian_rhythm1.26676164
73MP0001984_abnormal_olfaction1.24516400
74MP0010386_abnormal_urinary_bladder1.21620435
75MP0003633_abnormal_nervous_system1.17028929
76MP0005167_abnormal_blood-brain_barrier1.16379264
77MP0000427_abnormal_hair_cycle1.15775063
78MP0002127_abnormal_cardiovascular_syste1.13763437
79MP0008872_abnormal_physiological_respon1.11617466
80MP0004811_abnormal_neuron_physiology1.11484346
81MP0002229_neurodegeneration1.10717469
82MP0006082_CNS_inflammation1.08164134
83MP0001529_abnormal_vocalization1.07207236
84MP0001849_ear_inflammation1.06908352
85MP0004142_abnormal_muscle_tone1.03661918
86MP0003123_paternal_imprinting1.03595875
87MP0002067_abnormal_sensory_capabilities1.03235665
88MP0002752_abnormal_somatic_nervous1.02480263
89MP0000049_abnormal_middle_ear1.02317876
90MP0002882_abnormal_neuron_morphology1.01788991
91MP0003283_abnormal_digestive_organ1.00392655
92MP0002233_abnormal_nose_morphology0.99813604
93MP0003137_abnormal_impulse_conducting0.99516245
94MP0010030_abnormal_orbit_morphology0.97840346
95MP0001440_abnormal_grooming_behavior0.96655098
96MP0004957_abnormal_blastocyst_morpholog0.95690697
97MP0005174_abnormal_tail_pigmentation0.95687733
98MP0001501_abnormal_sleep_pattern0.94348204
99MP0005423_abnormal_somatic_nervous0.94242420
100MP0008569_lethality_at_weaning0.93601461
101MP0002932_abnormal_joint_morphology0.92737371
102MP0004215_abnormal_myocardial_fiber0.92722292
103MP0008770_decreased_survivor_rate0.92020540
104MP0003861_abnormal_nervous_system0.91662716
105MP0006072_abnormal_retinal_apoptosis0.91186687
106MP0001963_abnormal_hearing_physiology0.90690485
107MP0001485_abnormal_pinna_reflex0.90387038
108MP0002114_abnormal_axial_skeleton0.90202272
109MP0010352_gastrointestinal_tract_polyps0.90188578
110MP0003631_nervous_system_phenotype0.89551238
111MP0005535_abnormal_body_temperature0.87580882
112MP0002557_abnormal_social/conspecific_i0.86612392
113MP0000230_abnormal_systemic_arterial0.86532092
114MP0005380_embryogenesis_phenotype0.86343320
115MP0001672_abnormal_embryogenesis/_devel0.86343320
116MP0000015_abnormal_ear_pigmentation0.83882137
117MP0002138_abnormal_hepatobiliary_system0.83865909
118MP0000762_abnormal_tongue_morphology0.82386407
119MP0005266_abnormal_metabolism0.82274894
120MP0009780_abnormal_chondrocyte_physiolo0.82129245
121MP0002822_catalepsy0.81543019
122MP0005084_abnormal_gallbladder_morpholo0.81128924
123MP0003119_abnormal_digestive_system0.80571747
124MP0000372_irregular_coat_pigmentation0.79744410
125MP0003705_abnormal_hypodermis_morpholog0.77831431
126MP0002088_abnormal_embryonic_growth/wei0.76636593
127MP0003172_abnormal_lysosome_physiology0.76105462
128MP0006036_abnormal_mitochondrial_physio0.75808032
129MP0001764_abnormal_homeostasis0.75395950
130MP0000013_abnormal_adipose_tissue0.75040378
131MP0005623_abnormal_meninges_morphology0.74811359
132MP0001293_anophthalmia0.74734210
133MP0005670_abnormal_white_adipose0.74665731
134MP0002081_perinatal_lethality0.74285323
135MP0001905_abnormal_dopamine_level0.74092545
136MP0005310_abnormal_salivary_gland0.73564572
137MP0005332_abnormal_amino_acid0.72811204
138MP0009764_decreased_sensitivity_to0.72805141
139MP0003984_embryonic_growth_retardation0.72757330
140MP0003755_abnormal_palate_morphology0.71978805
141MP0002069_abnormal_eating/drinking_beha0.71839749
142MP0002152_abnormal_brain_morphology0.71253008
143MP0002066_abnormal_motor_capabilities/c0.71018796
144MP0000631_abnormal_neuroendocrine_gland0.69946714
145MP0003329_amyloid_beta_deposits0.68163037
146MP0000350_abnormal_cell_proliferation0.67620494
147MP0005410_abnormal_fertilization0.66890867
148MP0000026_abnormal_inner_ear0.65532266
149MP0001664_abnormal_digestion0.65477213
150MP0002970_abnormal_white_adipose0.65378909
151MP0004085_abnormal_heartbeat0.64782597
152MP0002092_abnormal_eye_morphology0.62439250
153MP0002085_abnormal_embryonic_tissue0.62058053
154MP0008874_decreased_physiological_sensi0.61127993
155MP0001270_distended_abdomen0.60623476
156MP0002116_abnormal_craniofacial_bone0.59251317

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.07991204
2Abnormality of the lower motor neuron (HP:0002366)6.40185617
3Hepatoblastoma (HP:0002884)4.93175315
4Hypochromic microcytic anemia (HP:0004840)4.66929422
5Amyotrophic lateral sclerosis (HP:0007354)4.19515931
6Rib fusion (HP:0000902)4.05832910
7Pancreatic cysts (HP:0001737)3.95088520
8Congenital stationary night blindness (HP:0007642)3.94851214
9Ependymoma (HP:0002888)3.79547636
10Molar tooth sign on MRI (HP:0002419)3.59169057
11Abnormality of midbrain morphology (HP:0002418)3.59169057
12Febrile seizures (HP:0002373)3.57483017
13Hyperventilation (HP:0002883)3.55363148
14Multiple enchondromatosis (HP:0005701)3.51004268
15Inability to walk (HP:0002540)3.34818623
16Type II lissencephaly (HP:0007260)3.34041539
17Progressive cerebellar ataxia (HP:0002073)3.32541770
18Amblyopia (HP:0000646)3.30256908
19Pancreatic fibrosis (HP:0100732)3.29184786
20Progressive inability to walk (HP:0002505)3.25753060
21Horizontal nystagmus (HP:0000666)3.18287547
22Rectovaginal fistula (HP:0000143)3.14139346
23Rectal fistula (HP:0100590)3.14139346
24True hermaphroditism (HP:0010459)3.11859889
25Bifid tongue (HP:0010297)3.11858939
26Generalized hypotonia (HP:0001290)3.11748283
27Neoplasm of striated muscle (HP:0009728)3.08110214
28Gaze-evoked nystagmus (HP:0000640)3.06580576
29Attenuation of retinal blood vessels (HP:0007843)3.01841739
30Anomalous pulmonary venous return (HP:0010772)3.01164577
31Abnormality of the astrocytes (HP:0100707)2.98568692
32Astrocytoma (HP:0009592)2.98568692
33Epileptic encephalopathy (HP:0200134)2.97835084
34Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.97583444
35Nephronophthisis (HP:0000090)2.91352934
36Focal seizures (HP:0007359)2.91059716
37Nephroblastoma (Wilms tumor) (HP:0002667)2.89247799
38Absent speech (HP:0001344)2.86249931
39Intestinal fistula (HP:0100819)2.85576999
40Rhabdomyosarcoma (HP:0002859)2.83444915
41Partial duplication of thumb phalanx (HP:0009944)2.82530032
42Chronic hepatic failure (HP:0100626)2.78326066
43Genetic anticipation (HP:0003743)2.76670758
44Abnormality of the renal cortex (HP:0011035)2.75245210
45Sensory axonal neuropathy (HP:0003390)2.75080380
46Embryonal renal neoplasm (HP:0011794)2.73225906
47Testicular atrophy (HP:0000029)2.71741899
48Abnormality of the corticospinal tract (HP:0002492)2.71544290
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70483963
50Abnormality of alanine metabolism (HP:0010916)2.70483963
51Hyperalaninemia (HP:0003348)2.70483963
52Hypoplasia of the fovea (HP:0007750)2.69575160
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.69575160
54Broad-based gait (HP:0002136)2.68928448
55Ragged-red muscle fibers (HP:0003200)2.67456860
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66415704
57Failure to thrive in infancy (HP:0001531)2.64005764
58Myokymia (HP:0002411)2.61387419
59Vaginal fistula (HP:0004320)2.59161173
60Atonic seizures (HP:0010819)2.58517501
61Abnormality of the salivary glands (HP:0010286)2.57344568
62Medial flaring of the eyebrow (HP:0010747)2.56958859
63Keratoconus (HP:0000563)2.52130367
64Increased corneal curvature (HP:0100692)2.52130367
65Focal motor seizures (HP:0011153)2.49970481
66Fused cervical vertebrae (HP:0002949)2.49249461
67Abolished electroretinogram (ERG) (HP:0000550)2.48392666
68Abnormality of the pulmonary veins (HP:0011718)2.47288545
69Abnormal drinking behavior (HP:0030082)2.45590586
70Polydipsia (HP:0001959)2.45590586
71Dialeptic seizures (HP:0011146)2.45558593
72Abnormality of the renal medulla (HP:0100957)2.45019012
73Neoplasm of the heart (HP:0100544)2.43950869
74Lissencephaly (HP:0001339)2.42940206
75Clumsiness (HP:0002312)2.42619500
76Periauricular skin pits (HP:0100277)2.41173591
77Preauricular pit (HP:0004467)2.41173591
783-Methylglutaconic aciduria (HP:0003535)2.40863000
79Progressive microcephaly (HP:0000253)2.39098495
80Atrophy/Degeneration involving motor neurons (HP:0007373)2.38770346
81Protruding tongue (HP:0010808)2.38607072
82Partial duplication of the phalanx of hand (HP:0009999)2.38442929
83Severe muscular hypotonia (HP:0006829)2.38111815
84Cerebellar dysplasia (HP:0007033)2.38053916
85Cystic liver disease (HP:0006706)2.37539362
86Large for gestational age (HP:0001520)2.36585112
87Shawl scrotum (HP:0000049)2.35745339
88Abnormal lung lobation (HP:0002101)2.33316895
89Hemiparesis (HP:0001269)2.33154410
90Retinal dysplasia (HP:0007973)2.32594094
91Decreased central vision (HP:0007663)2.32065216
92Tubular atrophy (HP:0000092)2.31632285
93Large earlobe (HP:0009748)2.30433799
94Generalized tonic-clonic seizures (HP:0002069)2.28147615
95Polyphagia (HP:0002591)2.27548034
96Hepatocellular necrosis (HP:0001404)2.27096250
97Pendular nystagmus (HP:0012043)2.26881754
98Pachygyria (HP:0001302)2.26577759
99Mitochondrial inheritance (HP:0001427)2.26561967
100Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24734561
101Abnormality of the pubic bones (HP:0003172)2.23433592
102Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.22577068
103Delayed CNS myelination (HP:0002188)2.21156049
104Malignant neoplasm of the central nervous system (HP:0100836)2.21072887
105Sclerocornea (HP:0000647)2.19600343
106Acute necrotizing encephalopathy (HP:0006965)2.19015511
107Gait imbalance (HP:0002141)2.18390942
108Tetraplegia (HP:0002445)2.18130149
109Increased CSF lactate (HP:0002490)2.17965872
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17761449
111Abnormality of the musculature of the hand (HP:0001421)2.17702715
112Aplasia/hypoplasia of the humerus (HP:0006507)2.17589680
113Difficulty running (HP:0009046)2.15950871
114Short humerus (HP:0005792)2.15764233
115Preauricular skin tag (HP:0000384)2.12479623
116Hand muscle atrophy (HP:0009130)2.12353600
117Abnormality of the fovea (HP:0000493)2.11477274
118Abnormal rod and cone electroretinograms (HP:0008323)2.11377760
119Limb dystonia (HP:0002451)2.10258117
120Resting tremor (HP:0002322)2.09768980
121Hepatic necrosis (HP:0002605)2.09479210
122Abnormality of macular pigmentation (HP:0008002)2.08616635
123Upper motor neuron abnormality (HP:0002127)2.07343568
124Progressive macrocephaly (HP:0004481)2.07093035
125Renal duplication (HP:0000075)2.06813711
126Tongue fasciculations (HP:0001308)2.06556932
127Abnormality of the phalanges of the hallux (HP:0010057)2.06507999
128Nasolacrimal duct obstruction (HP:0000579)2.04789375
129Agitation (HP:0000713)2.04779760
130Visual hallucinations (HP:0002367)2.04456625
131Supernumerary nipples (HP:0002558)2.04166589
132Abnormality of chromosome segregation (HP:0002916)2.03788655
133Decreased circulating renin level (HP:0003351)2.03662793
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.99832703
135Epileptiform EEG discharges (HP:0011182)1.99056278
136Glioma (HP:0009733)1.97607594
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.96428353
138Stomach cancer (HP:0012126)1.96265740
139Renal cortical cysts (HP:0000803)1.95998072
140Hypothermia (HP:0002045)1.95625423
141Acute encephalopathy (HP:0006846)1.95337793
142Neuroectodermal neoplasm (HP:0030061)1.94597835
143Neuroepithelial neoplasm (HP:0030063)1.94597835
144Nervous tissue neoplasm (HP:0030060)1.94597835
145Neuroblastoma (HP:0003006)1.93702865
146Primitive neuroectodermal tumor (HP:0030065)1.93702865
147Neuroblastic tumors (HP:0004376)1.93702865
148Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.93702865
149Abnormal mitochondria in muscle tissue (HP:0008316)1.93456962
150Abnormality of liposaccharide metabolism (HP:0010968)1.92851450
151Abnormality of glycosphingolipid metabolism (HP:0004343)1.92851450
152Abnormality of glycolipid metabolism (HP:0010969)1.92851450
153Polyuria (HP:0000103)1.92242082
154EEG with generalized epileptiform discharges (HP:0011198)1.91799818
155Upper limb muscle weakness (HP:0003484)1.91689102
156Hypsarrhythmia (HP:0002521)1.90183009
157Diplopia (HP:0000651)1.89281298
158Abnormality of binocular vision (HP:0011514)1.89281298
159Progressive muscle weakness (HP:0003323)1.89220561
160Optic disc pallor (HP:0000543)1.88761325
161Abnormal eating behavior (HP:0100738)1.88484885
162Status epilepticus (HP:0002133)1.87118935
163Prolonged QT interval (HP:0001657)1.86967837
164Absence seizures (HP:0002121)1.85979621
165Impaired pain sensation (HP:0007328)1.85471023
166Abnormality of pain sensation (HP:0010832)1.85471023
167Muscle fibrillation (HP:0010546)1.85330323
168Villous atrophy (HP:0011473)1.84654871
169Abnormality of small intestinal villus morphology (HP:0011472)1.84654871
170Skin tags (HP:0010609)1.83070769
171Supernumerary spleens (HP:0009799)1.82746239
172Ketosis (HP:0001946)1.82345075
173Webbed neck (HP:0000465)1.82007377
174Dysphonia (HP:0001618)1.81893965
175Congenital hepatic fibrosis (HP:0002612)1.81386571
176Nasal polyposis (HP:0100582)1.80954098
177Congenital primary aphakia (HP:0007707)1.80811447
178Mutism (HP:0002300)1.80665870
179Concave nail (HP:0001598)1.80313429
180Progressive external ophthalmoplegia (HP:0000590)1.79980284
181Abnormality of the motor neurons (HP:0002450)1.79650547
182Urinary bladder sphincter dysfunction (HP:0002839)1.77844570
183Nephrogenic diabetes insipidus (HP:0009806)1.77728172
184Opisthotonus (HP:0002179)1.76970734
185Hemiplegia (HP:0002301)1.76217107
186Bony spicule pigmentary retinopathy (HP:0007737)1.74127242
187Ketoacidosis (HP:0001993)1.73848439
188Chorioretinal atrophy (HP:0000533)1.72919812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.64475654
2GRK55.91942675
3FRK5.12865132
4GRK64.18132171
5MAP4K23.60480151
6ERN13.13070106
7ADRBK23.02765045
8TYRO32.71886746
9PINK12.64590029
10MAP3K92.60660653
11GRK12.59481188
12GRK72.47151318
13TLK12.43530100
14CSF1R2.36533064
15NTRK12.33397627
16MATK2.27257531
17MAPK71.97581850
18NTRK31.96438986
19WNK11.93116307
20INSRR1.93061281
21MAP2K41.87232491
22TAOK31.83947209
23MOS1.83896373
24TXK1.83802807
25ZAK1.79452435
26WNK31.75831442
27MARK11.74239062
28TGFBR21.72616592
29WNK41.72270315
30OXSR11.71156313
31BMPR1B1.66940664
32BCKDK1.63853511
33CAMK41.53663873
34MAP2K61.52454116
35MARK21.48061014
36NUAK11.47908637
37EPHA41.41855138
38MINK11.38696395
39CAMKK21.32134836
40PRKG21.28996504
41ADRBK11.25894084
42PRPF4B1.23757724
43LIMK11.17080112
44NTRK21.13943562
45STK101.12906826
46TAOK21.12711464
47CSNK1G21.12266165
48TTK1.11666573
49STK391.07988217
50PAK61.04763822
51LATS21.03293283
52PIM21.03212264
53MAPKAPK30.98937374
54HIPK20.97572966
55CSNK1G30.97342837
56FGFR30.96092506
57PRKD30.95865472
58ACVR1B0.95565435
59AKT30.94280112
60PRKCE0.93523219
61MAP3K40.91554765
62CAMKK10.89682768
63CAMK2A0.89576965
64CSNK1A1L0.88225618
65SIK20.87769726
66PKN10.86763924
67MAP3K70.83844624
68DAPK20.83563040
69MAP3K110.82311942
70ALK0.82087553
71DYRK20.78419917
72SIK30.75995086
73MUSK0.75320031
74CDK70.70832773
75CSNK1G10.69686103
76MAP3K120.69003580
77KSR20.68930507
78STK110.66735757
79MAPK120.65437040
80RIPK40.64699837
81CDK180.64233084
82PRKCG0.63650314
83CDK50.62122829
84CDK150.61272749
85IKBKB0.60777100
86CHEK20.60175999
87PTK2B0.59965699
88PRKCQ0.59753360
89PHKG10.59271321
90PHKG20.59271321
91PAK40.58576576
92TIE10.58312959
93TESK20.56234489
94CAMK2B0.54685972
95CDK11A0.54464239
96DYRK1A0.53670209
97MAPK130.53234787
98CDK140.53023138
99UHMK10.52677020
100MAP2K70.52204831
101CDK190.52194694
102PAK30.50399760
103DAPK10.50319436
104PRKCZ0.49901001
105CASK0.49868659
106PRKCI0.47011246
107PRKAA10.46928362
108AKT20.46333025
109PRKCA0.46264179
110EPHA20.44287506
111MAPKAPK50.43194016
112CAMK2D0.42296752
113MAP3K100.41955638
114MAPK100.41360269
115KDR0.40055507
116RPS6KA50.38957427
117CSNK1A10.38793208
118ARAF0.38758415
119KSR10.38694452
120DAPK30.37490560
121TAOK10.37139201
122CAMK2G0.37083496
123EIF2AK20.36938190
124PLK10.36358463
125CSNK1E0.35279661
126STK380.34832611
127MAP2K10.33825866
128PLK20.33473621
129TNK20.33377138
130SYK0.33183433
131CSNK1D0.32929023
132KIT0.32507987
133OBSCN0.32089888
134SGK4940.30911988
135SGK2230.30911988
136PRKCD0.30615604
137PRKG10.29496772
138LMTK20.29338921
139MAP3K130.28591140
140IGF1R0.27812274
141ROCK10.27087975
142PTK20.27051180
143EPHA30.26112797
144CAMK10.26098438
145NME10.25788744
146PRKCH0.25569466
147CCNB10.25037677
148CSK0.24916494
149CHEK10.24748818
150PDK10.24560832
151RPS6KA30.22891133
152GSK3B0.22498004
153MAPK40.21958888
154PRKACG0.21384963
155PRKACA0.20414712
156CDK20.19383513
157PRKD20.19118244
158INSR0.18593803
159MAPK80.17877873
160PRKACB0.17339385

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.87015978
2Vitamin B6 metabolism_Homo sapiens_hsa007503.28678941
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.59124283
4Phototransduction_Homo sapiens_hsa047442.57560301
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.53531521
6Fructose and mannose metabolism_Homo sapiens_hsa000512.53120295
7Synaptic vesicle cycle_Homo sapiens_hsa047212.40517534
8Nicotine addiction_Homo sapiens_hsa050332.13866151
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.11115341
10Butanoate metabolism_Homo sapiens_hsa006501.99803067
11Long-term potentiation_Homo sapiens_hsa047201.96348715
12Olfactory transduction_Homo sapiens_hsa047401.95674040
13Glutamatergic synapse_Homo sapiens_hsa047241.91578410
14Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.88256591
15GABAergic synapse_Homo sapiens_hsa047271.87304161
16Taste transduction_Homo sapiens_hsa047421.79599806
17Oxidative phosphorylation_Homo sapiens_hsa001901.74924654
18Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.66242474
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.65765619
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62841492
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58831299
22Galactose metabolism_Homo sapiens_hsa000521.52889044
23Serotonergic synapse_Homo sapiens_hsa047261.52492253
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49492629
25mTOR signaling pathway_Homo sapiens_hsa041501.48912888
26Nitrogen metabolism_Homo sapiens_hsa009101.48708450
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48650798
28Dopaminergic synapse_Homo sapiens_hsa047281.45781627
29Long-term depression_Homo sapiens_hsa047301.45406605
30GnRH signaling pathway_Homo sapiens_hsa049121.44307493
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.39906315
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39050331
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36467793
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36266216
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.35270692
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33307354
37Circadian entrainment_Homo sapiens_hsa047131.33074087
38Tryptophan metabolism_Homo sapiens_hsa003801.30756923
39Salivary secretion_Homo sapiens_hsa049701.30449236
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28507222
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28035384
42Regulation of autophagy_Homo sapiens_hsa041401.25700900
43Calcium signaling pathway_Homo sapiens_hsa040201.24559010
44Parkinsons disease_Homo sapiens_hsa050121.23629429
45Morphine addiction_Homo sapiens_hsa050321.22381529
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21880753
47Arachidonic acid metabolism_Homo sapiens_hsa005901.20840615
48Thyroid cancer_Homo sapiens_hsa052161.18382457
49Selenocompound metabolism_Homo sapiens_hsa004501.18296037
50Oxytocin signaling pathway_Homo sapiens_hsa049211.17954942
51Peroxisome_Homo sapiens_hsa041461.14779952
52Amphetamine addiction_Homo sapiens_hsa050311.13559049
53ABC transporters_Homo sapiens_hsa020101.09654999
54Choline metabolism in cancer_Homo sapiens_hsa052311.09401107
55Alzheimers disease_Homo sapiens_hsa050101.08311461
56Axon guidance_Homo sapiens_hsa043601.05700191
57Cholinergic synapse_Homo sapiens_hsa047251.03625909
58Maturity onset diabetes of the young_Homo sapiens_hsa049501.03438380
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02733930
60Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02334607
61Rap1 signaling pathway_Homo sapiens_hsa040151.01090432
62VEGF signaling pathway_Homo sapiens_hsa043701.00983436
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.99800130
64Caffeine metabolism_Homo sapiens_hsa002320.95448115
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95266148
66Inositol phosphate metabolism_Homo sapiens_hsa005620.95032942
67ErbB signaling pathway_Homo sapiens_hsa040120.94501637
68Sulfur metabolism_Homo sapiens_hsa009200.93498843
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91324785
70Collecting duct acid secretion_Homo sapiens_hsa049660.89898626
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89244444
72Non-small cell lung cancer_Homo sapiens_hsa052230.87709122
73cAMP signaling pathway_Homo sapiens_hsa040240.87586240
74Gap junction_Homo sapiens_hsa045400.87300502
75Renin secretion_Homo sapiens_hsa049240.87023311
76Insulin secretion_Homo sapiens_hsa049110.84944495
77African trypanosomiasis_Homo sapiens_hsa051430.83484002
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.83330728
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80371432
80Propanoate metabolism_Homo sapiens_hsa006400.80208412
81Glioma_Homo sapiens_hsa052140.79768612
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.79529490
83MAPK signaling pathway_Homo sapiens_hsa040100.79506926
84Sulfur relay system_Homo sapiens_hsa041220.78741205
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.78589370
86Cardiac muscle contraction_Homo sapiens_hsa042600.77227972
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.76036386
88Linoleic acid metabolism_Homo sapiens_hsa005910.75919573
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.75819752
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.75770067
91beta-Alanine metabolism_Homo sapiens_hsa004100.75568647
92Ras signaling pathway_Homo sapiens_hsa040140.75173384
93Gastric acid secretion_Homo sapiens_hsa049710.73844764
94Hedgehog signaling pathway_Homo sapiens_hsa043400.72010209
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69663463
96Protein export_Homo sapiens_hsa030600.69421223
97Glycerolipid metabolism_Homo sapiens_hsa005610.69247225
98Dorso-ventral axis formation_Homo sapiens_hsa043200.68800952
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68384491
100Melanogenesis_Homo sapiens_hsa049160.66811086
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66009607
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65642530
103Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65210245
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64702388
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62479791
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.61114291
107Endometrial cancer_Homo sapiens_hsa052130.60354414
108Ovarian steroidogenesis_Homo sapiens_hsa049130.59841031
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59826950
110Wnt signaling pathway_Homo sapiens_hsa043100.59815096
111mRNA surveillance pathway_Homo sapiens_hsa030150.59807465
112Oocyte meiosis_Homo sapiens_hsa041140.59139573
113Chemical carcinogenesis_Homo sapiens_hsa052040.59023943
114Pathways in cancer_Homo sapiens_hsa052000.58601336
115Colorectal cancer_Homo sapiens_hsa052100.58245894
116Huntingtons disease_Homo sapiens_hsa050160.58151021
117Basal transcription factors_Homo sapiens_hsa030220.57746016
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57187507
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56921292
120Circadian rhythm_Homo sapiens_hsa047100.56568085
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56556592
122Histidine metabolism_Homo sapiens_hsa003400.56388568
123Cocaine addiction_Homo sapiens_hsa050300.55519806
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55389954
125Acute myeloid leukemia_Homo sapiens_hsa052210.54398659
126T cell receptor signaling pathway_Homo sapiens_hsa046600.53726177
127Estrogen signaling pathway_Homo sapiens_hsa049150.53588340
128B cell receptor signaling pathway_Homo sapiens_hsa046620.51773545
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51101702
130Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50595591
131Rheumatoid arthritis_Homo sapiens_hsa053230.49696897
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49227994
133RNA polymerase_Homo sapiens_hsa030200.49130421
134Homologous recombination_Homo sapiens_hsa034400.48786891
135Fatty acid biosynthesis_Homo sapiens_hsa000610.48106681
136Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47697962
137Basal cell carcinoma_Homo sapiens_hsa052170.47012735
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46918324
139Retinol metabolism_Homo sapiens_hsa008300.43818852
140Primary immunodeficiency_Homo sapiens_hsa053400.42879785
141Endocytosis_Homo sapiens_hsa041440.41972655
142Dilated cardiomyopathy_Homo sapiens_hsa054140.41968913
143Ether lipid metabolism_Homo sapiens_hsa005650.41657305
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41393739
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.40916591
146Mineral absorption_Homo sapiens_hsa049780.39541173
147Metabolic pathways_Homo sapiens_hsa011000.39356408
148Hippo signaling pathway_Homo sapiens_hsa043900.38749183
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38433104
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35684739
151Prolactin signaling pathway_Homo sapiens_hsa049170.34529826
152Lysosome_Homo sapiens_hsa041420.34320602
153Fanconi anemia pathway_Homo sapiens_hsa034600.33612150
154Pancreatic secretion_Homo sapiens_hsa049720.33247466
155Fatty acid elongation_Homo sapiens_hsa000620.33181067
156Arginine and proline metabolism_Homo sapiens_hsa003300.32973499
157Type II diabetes mellitus_Homo sapiens_hsa049300.32023237
158Sphingolipid metabolism_Homo sapiens_hsa006000.30008198

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