STOML2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.96742369
2DNA strand elongation involved in DNA replication (GO:0006271)4.93843762
3maturation of SSU-rRNA (GO:0030490)4.91964238
4DNA deamination (GO:0045006)4.72387669
5DNA strand elongation (GO:0022616)4.69516046
6viral transcription (GO:0019083)4.69233907
7nucleobase biosynthetic process (GO:0046112)4.66859091
8DNA replication initiation (GO:0006270)4.63981742
9translational termination (GO:0006415)4.60167967
10telomere maintenance via semi-conservative replication (GO:0032201)4.58541269
11DNA unwinding involved in DNA replication (GO:0006268)4.58288214
12formation of translation preinitiation complex (GO:0001731)4.42328570
13purine nucleobase biosynthetic process (GO:0009113)4.38671207
14translational elongation (GO:0006414)4.32924631
15ribosomal large subunit biogenesis (GO:0042273)4.28970623
16folic acid-containing compound biosynthetic process (GO:0009396)4.25803802
17* mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23382816
18ribosomal small subunit biogenesis (GO:0042274)4.17556215
19translational initiation (GO:0006413)4.07040567
20DNA replication checkpoint (GO:0000076)4.05868450
21proteasome assembly (GO:0043248)4.02087363
22establishment of viral latency (GO:0019043)3.98539443
23telomere maintenance via recombination (GO:0000722)3.97304151
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.97238673
25chaperone-mediated protein transport (GO:0072321)3.97199610
26ribonucleoprotein complex biogenesis (GO:0022613)3.90103985
27cotranslational protein targeting to membrane (GO:0006613)3.87682725
28protein targeting to ER (GO:0045047)3.85883257
29spliceosomal snRNP assembly (GO:0000387)3.83531248
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.81318658
31mitotic metaphase plate congression (GO:0007080)3.80576277
32establishment of integrated proviral latency (GO:0075713)3.77317277
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.75943868
34IMP biosynthetic process (GO:0006188)3.72709221
35protein localization to kinetochore (GO:0034501)3.72113734
36ribosome biogenesis (GO:0042254)3.72034364
37mitotic recombination (GO:0006312)3.71809311
38DNA replication-dependent nucleosome organization (GO:0034723)3.67673447
39DNA replication-dependent nucleosome assembly (GO:0006335)3.67673447
40telomere maintenance via telomere lengthening (GO:0010833)3.66840658
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.65706193
42protein localization to endoplasmic reticulum (GO:0070972)3.64791913
43establishment of protein localization to endoplasmic reticulum (GO:0072599)3.64627304
44cellular protein complex disassembly (GO:0043624)3.64079159
45CENP-A containing nucleosome assembly (GO:0034080)3.62708834
46deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.62441776
47viral life cycle (GO:0019058)3.61838015
48chromatin remodeling at centromere (GO:0031055)3.61387898
49ribosome assembly (GO:0042255)3.59454882
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.57015570
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.55156236
52* energy coupled proton transport, down electrochemical gradient (GO:0015985)3.53558447
53* ATP synthesis coupled proton transport (GO:0015986)3.53558447
54rRNA processing (GO:0006364)3.49629908
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49629527
56translation (GO:0006412)3.49022905
57folic acid metabolic process (GO:0046655)3.48602759
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48302361
59protein targeting to mitochondrion (GO:0006626)3.46807676
60pseudouridine synthesis (GO:0001522)3.39373035
61oxidative phosphorylation (GO:0006119)3.39004084
62rRNA metabolic process (GO:0016072)3.36399694
63negative regulation of ligase activity (GO:0051352)3.33983535
64negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.33983535
65viral mRNA export from host cell nucleus (GO:0046784)3.33811051
66mitotic nuclear envelope disassembly (GO:0007077)3.33057064
67IMP metabolic process (GO:0046040)3.32435102
68metaphase plate congression (GO:0051310)3.30604719
69transcription-coupled nucleotide-excision repair (GO:0006283)3.29033297
70L-serine metabolic process (GO:0006563)3.28279576
71pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.27549682
72protein complex disassembly (GO:0043241)3.27497267
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.27011814
74spliceosomal complex assembly (GO:0000245)3.25416092
75cullin deneddylation (GO:0010388)3.23908364
76DNA replication-independent nucleosome assembly (GO:0006336)3.22257679
77DNA replication-independent nucleosome organization (GO:0034724)3.22257679
78pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.20679420
79establishment of protein localization to mitochondrion (GO:0072655)3.18968135
80respiratory electron transport chain (GO:0022904)3.18308067
81pteridine-containing compound biosynthetic process (GO:0042559)3.17562089
82protein deneddylation (GO:0000338)3.17041444
83regulation of ubiquitin-protein transferase activity (GO:0051438)3.17040888
84cellular component biogenesis (GO:0044085)3.17027752
85termination of RNA polymerase III transcription (GO:0006386)3.14938835
86transcription elongation from RNA polymerase III promoter (GO:0006385)3.14938835
87regulation of translational fidelity (GO:0006450)3.14877719
88macromolecular complex disassembly (GO:0032984)3.13657512
89protein localization to mitochondrion (GO:0070585)3.13372865
90protein maturation by protein folding (GO:0022417)3.12343025
91rRNA modification (GO:0000154)3.12302271
92guanosine-containing compound biosynthetic process (GO:1901070)3.12251204
93protein localization to chromosome, centromeric region (GO:0071459)3.10389780
94positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.09341356
95electron transport chain (GO:0022900)3.08433460
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08420589
97G1/S transition of mitotic cell cycle (GO:0000082)3.08206907
98cell cycle G1/S phase transition (GO:0044843)3.08206907
99regulation of cellular amino acid metabolic process (GO:0006521)3.06354616
100regulation of ligase activity (GO:0051340)3.04348356
101mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.03263223
102signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02751354
103intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02751354
104rRNA methylation (GO:0031167)3.02582188
105membrane disassembly (GO:0030397)3.02380281
106nuclear envelope disassembly (GO:0051081)3.02380281
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00204727
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00204727
109signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00204727
110pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.00034402
111nuclear-transcribed mRNA catabolic process (GO:0000956)2.99072147
112signal transduction involved in DNA damage checkpoint (GO:0072422)2.98730072
113signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98730072
114DNA ligation (GO:0006266)2.97266868
115positive regulation of ligase activity (GO:0051351)2.96349699
116mitotic sister chromatid segregation (GO:0000070)2.95139466
117signal transduction involved in cell cycle checkpoint (GO:0072395)2.94990568
118pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94884469
119DNA damage response, detection of DNA damage (GO:0042769)2.94430260
120pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.93780539
121histone exchange (GO:0043486)2.93046307
122regulation of mitochondrial translation (GO:0070129)2.92119866
123nucleobase-containing small molecule interconversion (GO:0015949)2.91931135
124tetrahydrofolate metabolic process (GO:0046653)2.90900919
125establishment of chromosome localization (GO:0051303)2.89863120
126tRNA aminoacylation for protein translation (GO:0006418)2.89577512
127glycine metabolic process (GO:0006544)2.89206457

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.15488125
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.59669024
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.26528424
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61774526
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.26163635
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21771259
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.15249444
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.14478611
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13631787
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.13175240
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.12635971
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.04541406
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99649724
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.89026800
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80148354
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.74480685
17* XRN2_22483619_ChIP-Seq_HELA_Human2.51494205
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49539404
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.41067192
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40277357
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28108306
22* VDR_23849224_ChIP-Seq_CD4+_Human2.22670693
23DCP1A_22483619_ChIP-Seq_HELA_Human2.16506873
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10389234
25* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.03374663
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03329003
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01748589
28GABP_19822575_ChIP-Seq_HepG2_Human2.00659616
29* FOXP3_21729870_ChIP-Seq_TREG_Human1.97911775
30TTF2_22483619_ChIP-Seq_HELA_Human1.90248727
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87919630
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.84678859
33AR_21909140_ChIP-Seq_LNCAP_Human1.83961372
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82126746
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82120871
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81597922
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81174823
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.78243301
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71807420
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71588620
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.70953198
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.67929389
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67880600
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62436049
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.61492606
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57226824
47CIITA_25753668_ChIP-Seq_RAJI_Human1.57013927
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51823717
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50620982
50ZNF263_19887448_ChIP-Seq_K562_Human1.49163821
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44799276
52ELK1_19687146_ChIP-ChIP_HELA_Human1.43906742
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43855079
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.42312324
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.42126220
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38969698
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38635719
58KDM5A_27292631_Chip-Seq_BREAST_Human1.35122783
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33984491
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29552079
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26184948
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23268973
63KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21541097
64RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19849338
65MYC_22102868_ChIP-Seq_BL_Human1.18754674
66KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17990578
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17223845
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17124246
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16065797
70SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13826480
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13331173
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12289526
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11454446
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.10035784
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.09905128
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09841542
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09385945
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06390096
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05937711
80TFEB_21752829_ChIP-Seq_HELA_Human1.04816915
81* MYC_18940864_ChIP-ChIP_HL60_Human1.04642021
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04520352
83CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04370330
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02708782
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01652024
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99655688
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99176726
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97972085
89* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97709376
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96785877
91ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96549624
92FOXP1_21924763_ChIP-Seq_HESCs_Human0.96468530
93CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96468164
94SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96374340
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95925955
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.95033199
97* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94887894
98* SOX17_20123909_ChIP-Seq_XEN_Mouse0.94411314
99SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92897414
100HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92601619
101TBX5_21415370_ChIP-Seq_HL-1_Mouse0.89933924
102* TET1_21451524_ChIP-Seq_MESCs_Mouse0.89191555
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88384501
104EGR1_19374776_ChIP-ChIP_THP-1_Human0.87866571
105* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86167608
106NOTCH1_21737748_ChIP-Seq_TLL_Human0.84277575
107SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83750013
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83011118
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.81817429
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.80167659
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.79527394
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79525240
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79466424
114SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79406596

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.71564921
2MP0004957_abnormal_blastocyst_morpholog4.78758322
3MP0010094_abnormal_chromosome_stability4.54614526
4MP0003111_abnormal_nucleus_morphology4.46047036
5MP0003077_abnormal_cell_cycle4.04960318
6MP0003806_abnormal_nucleotide_metabolis3.81597837
7MP0008058_abnormal_DNA_repair3.46360436
8MP0008057_abnormal_DNA_replication3.25633464
9MP0008932_abnormal_embryonic_tissue2.98745104
10MP0008007_abnormal_cellular_replicative2.76543449
11MP0003123_paternal_imprinting2.47771832
12MP0001730_embryonic_growth_arrest2.47629703
13MP0000350_abnormal_cell_proliferation2.07765999
14MP0003718_maternal_effect1.97479340
15MP0003186_abnormal_redox_activity1.96146617
16MP0006036_abnormal_mitochondrial_physio1.84840690
17MP0002396_abnormal_hematopoietic_system1.80315160
18MP0001697_abnormal_embryo_size1.76862855
19MP0003786_premature_aging1.72236962
20MP0001672_abnormal_embryogenesis/_devel1.70718694
21MP0005380_embryogenesis_phenotype1.70718694
22MP0002080_prenatal_lethality1.68053177
23MP0010030_abnormal_orbit_morphology1.60068435
24MP0005451_abnormal_body_composition1.55782027
25MP0006035_abnormal_mitochondrial_morpho1.55557059
26MP0003984_embryonic_growth_retardation1.51782756
27MP0000490_abnormal_crypts_of1.50189842
28MP0009379_abnormal_foot_pigmentation1.50021973
29MP0002088_abnormal_embryonic_growth/wei1.48326453
30MP0004133_heterotaxia1.47688490
31MP0000313_abnormal_cell_death1.44674113
32MP0010352_gastrointestinal_tract_polyps1.44239647
33MP0002085_abnormal_embryonic_tissue1.44186202
34MP0008877_abnormal_DNA_methylation1.41854523
35MP0002019_abnormal_tumor_incidence1.37378174
36MP0003567_abnormal_fetal_cardiomyocyte1.35219829
37MP0003315_abnormal_perineum_morphology1.34292640
38MP0000358_abnormal_cell_content/1.30985760
39MP0002938_white_spotting1.29831522
40MP0002084_abnormal_developmental_patter1.26090808
41MP0001346_abnormal_lacrimal_gland1.25084950
42MP0010307_abnormal_tumor_latency1.23304508
43MP0000537_abnormal_urethra_morphology1.21864091
44MP0002086_abnormal_extraembryonic_tissu1.20243173
45MP0008789_abnormal_olfactory_epithelium1.19597771
46MP0003119_abnormal_digestive_system1.18266940
47MP0002160_abnormal_reproductive_system1.17339970
48MP0009053_abnormal_anal_canal1.17183848
49MP0004197_abnormal_fetal_growth/weight/1.15895154
50MP0002132_abnormal_respiratory_system1.15792577
51MP0001661_extended_life_span1.14442175
52MP0005410_abnormal_fertilization1.11718343
53MP0009333_abnormal_splenocyte_physiolog1.10568703
54MP0001529_abnormal_vocalization1.10384966
55MP0001764_abnormal_homeostasis1.09502820
56MP0002234_abnormal_pharynx_morphology1.09492185
57MP0000678_abnormal_parathyroid_gland1.08006150
58MP0001293_anophthalmia1.07428266
59MP0004233_abnormal_muscle_weight1.05377448
60MP0002139_abnormal_hepatobiliary_system1.05223439
61MP0005266_abnormal_metabolism1.05184194
62MP0003890_abnormal_embryonic-extraembry1.04504926
63MP0002796_impaired_skin_barrier1.02609560
64MP0003221_abnormal_cardiomyocyte_apopto1.01429430
65MP0002210_abnormal_sex_determination0.99798664
66MP0009672_abnormal_birth_weight0.98471610
67MP0000049_abnormal_middle_ear0.96923198
68MP0000749_muscle_degeneration0.96223557
69MP0003646_muscle_fatigue0.96122382
70MP0005408_hypopigmentation0.92801003
71MP0001145_abnormal_male_reproductive0.92782332
72MP0008260_abnormal_autophagy0.92566748
73MP0003656_abnormal_erythrocyte_physiolo0.91713710
74MP0002697_abnormal_eye_size0.90948295
75MP0004147_increased_porphyrin_level0.90696277
76MP0005360_urolithiasis0.90643610
77MP0000566_synostosis0.90118285
78MP0000762_abnormal_tongue_morphology0.89549508
79MP0005389_reproductive_system_phenotype0.86983963
80MP0001853_heart_inflammation0.85247485
81MP0009840_abnormal_foam_cell0.85226580
82MP0000750_abnormal_muscle_regeneration0.85180569
83MP0002111_abnormal_tail_morphology0.84922996
84MP0005085_abnormal_gallbladder_physiolo0.83653333
85MP0000751_myopathy0.83071582
86MP0003937_abnormal_limbs/digits/tail_de0.82937605
87MP0001881_abnormal_mammary_gland0.80877800
88MP0001727_abnormal_embryo_implantation0.79655399
89MP0000858_altered_metastatic_potential0.78306595
90MP0005670_abnormal_white_adipose0.77549490
91MP0000653_abnormal_sex_gland0.77023260
92MP0005499_abnormal_olfactory_system0.76835390
93MP0005394_taste/olfaction_phenotype0.76835390
94MP0008995_early_reproductive_senescence0.75893582
95MP0006054_spinal_hemorrhage0.74915993
96MP0004808_abnormal_hematopoietic_stem0.74905400
97MP0003121_genomic_imprinting0.74865505
98MP0000372_irregular_coat_pigmentation0.74571386
99MP0006292_abnormal_olfactory_placode0.74361471
100MP0002653_abnormal_ependyma_morphology0.74015696
101MP0005332_abnormal_amino_acid0.73519436
102MP0001119_abnormal_female_reproductive0.73294642
103MP0002269_muscular_atrophy0.73157840
104MP0002163_abnormal_gland_morphology0.72843742
105MP0001286_abnormal_eye_development0.72440734
106MP0002233_abnormal_nose_morphology0.72214478
107MP0000598_abnormal_liver_morphology0.72121579
108MP0005384_cellular_phenotype0.71510932
109MP0000703_abnormal_thymus_morphology0.71455632
110MP0005501_abnormal_skin_physiology0.71217421
111MP0002877_abnormal_melanocyte_morpholog0.71169995
112MP0005623_abnormal_meninges_morphology0.71097411
113MP0002722_abnormal_immune_system0.69870117
114MP0005397_hematopoietic_system_phenotyp0.69160156
115MP0001545_abnormal_hematopoietic_system0.69160156
116MP0001929_abnormal_gametogenesis0.68529266
117MP0005395_other_phenotype0.67313660
118MP0003698_abnormal_male_reproductive0.67306385
119MP0002102_abnormal_ear_morphology0.66673270
120MP0005319_abnormal_enzyme/_coenzyme0.66650487
121MP0002161_abnormal_fertility/fecundity0.66503084
122MP0004272_abnormal_basement_membrane0.66474235
123MP0000689_abnormal_spleen_morphology0.66057120
124MP0003941_abnormal_skin_development0.65359127
125MP0005075_abnormal_melanosome_morpholog0.62229564
126MP0004084_abnormal_cardiac_muscle0.60814720
127MP0005023_abnormal_wound_healing0.59092352
128MP0009697_abnormal_copulation0.58722362
129MP0000467_abnormal_esophagus_morphology0.58365327
130MP0000477_abnormal_intestine_morphology0.58035684
131MP0004185_abnormal_adipocyte_glucose0.56980293
132MP0001919_abnormal_reproductive_system0.56943727
133MP0005365_abnormal_bile_salt0.56728064
134MP0005330_cardiomyopathy0.56311116
135MP0001915_intracranial_hemorrhage0.55947897
136MP0003763_abnormal_thymus_physiology0.55650359
137MP0001849_ear_inflammation0.55335615
138MP0003011_delayed_dark_adaptation0.54774100
139MP0005376_homeostasis/metabolism_phenot0.54453721

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.01747423
2Reticulocytopenia (HP:0001896)4.78693763
3Abnormal number of erythroid precursors (HP:0012131)4.64588148
4Birth length less than 3rd percentile (HP:0003561)4.60533320
5Oral leukoplakia (HP:0002745)4.24469645
6Breast hypoplasia (HP:0003187)3.86883883
7Macrocytic anemia (HP:0001972)3.66164269
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.43457543
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.43457543
10Cerebral hypomyelination (HP:0006808)3.34335998
11Hepatocellular necrosis (HP:0001404)3.33963917
12Colon cancer (HP:0003003)3.33668069
13Hepatic necrosis (HP:0002605)3.26472279
14Increased serum lactate (HP:0002151)3.23042783
15Abnormality of pyrimidine metabolism (HP:0004353)3.14764127
16Type I transferrin isoform profile (HP:0003642)3.09473161
17Increased serum pyruvate (HP:0003542)3.06995126
18Abnormality of glycolysis (HP:0004366)3.06995126
19Pallor (HP:0000980)3.02973804
20Rough bone trabeculation (HP:0100670)3.02833098
21Degeneration of anterior horn cells (HP:0002398)3.00363118
22Abnormality of the anterior horn cell (HP:0006802)3.00363118
23Multiple enchondromatosis (HP:0005701)2.98048453
24Renal Fanconi syndrome (HP:0001994)2.96964702
25Increased CSF lactate (HP:0002490)2.95968300
26Mitochondrial inheritance (HP:0001427)2.92194815
27Selective tooth agenesis (HP:0001592)2.91045552
28Carpal bone hypoplasia (HP:0001498)2.90133297
29Acute necrotizing encephalopathy (HP:0006965)2.88831803
30Aplastic anemia (HP:0001915)2.87522106
31Patellar aplasia (HP:0006443)2.81968969
32Ependymoma (HP:0002888)2.79234786
33Reduced antithrombin III activity (HP:0001976)2.78692572
34Abnormal mitochondria in muscle tissue (HP:0008316)2.75508243
35Microretrognathia (HP:0000308)2.73490885
36Aplasia/Hypoplasia of the patella (HP:0006498)2.69393165
37Testicular atrophy (HP:0000029)2.67789966
38Absent thumb (HP:0009777)2.64337413
39Trismus (HP:0000211)2.63712633
40Acute encephalopathy (HP:0006846)2.61106713
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.54021130
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.53899467
43Lactic acidosis (HP:0003128)2.49821937
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.46838452
45Abnormal protein N-linked glycosylation (HP:0012347)2.46838452
46Abnormal protein glycosylation (HP:0012346)2.46838452
47Abnormal glycosylation (HP:0012345)2.46838452
48Secondary amenorrhea (HP:0000869)2.44281849
49Lipid accumulation in hepatocytes (HP:0006561)2.42638745
50Increased hepatocellular lipid droplets (HP:0006565)2.41679535
51Ragged-red muscle fibers (HP:0003200)2.38297319
52Abnormality of reticulocytes (HP:0004312)2.37809436
53Neoplasm of the pancreas (HP:0002894)2.37479973
54Megaloblastic anemia (HP:0001889)2.36719276
55Facial cleft (HP:0002006)2.36042929
56Medulloblastoma (HP:0002885)2.35755288
57Abnormality of the heme biosynthetic pathway (HP:0010472)2.35636942
58Meckel diverticulum (HP:0002245)2.33862457
59Cellular immunodeficiency (HP:0005374)2.31851155
60Cerebral edema (HP:0002181)2.31725903
61Abnormality of the preputium (HP:0100587)2.30678893
62Nausea (HP:0002018)2.28392300
63Microvesicular hepatic steatosis (HP:0001414)2.27762577
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27584287
65Abnormality of alanine metabolism (HP:0010916)2.27584287
66Hyperalaninemia (HP:0003348)2.27584287
67Premature ovarian failure (HP:0008209)2.26553996
6811 pairs of ribs (HP:0000878)2.24259083
69Agnosia (HP:0010524)2.24181512
70Gout (HP:0001997)2.23997161
71Horseshoe kidney (HP:0000085)2.23784334
723-Methylglutaconic aciduria (HP:0003535)2.22903145
73Abnormality of the ileum (HP:0001549)2.22880265
74Absent radius (HP:0003974)2.22563414
75CNS demyelination (HP:0007305)2.21779453
76Pancytopenia (HP:0001876)2.21529931
77Exercise intolerance (HP:0003546)2.21372976
78Sparse eyelashes (HP:0000653)2.20295122
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20140766
80Premature graying of hair (HP:0002216)2.19394867
81Abnormality of methionine metabolism (HP:0010901)2.19036471
82Rhabdomyosarcoma (HP:0002859)2.18939098
83Cholecystitis (HP:0001082)2.18390825
84Abnormal gallbladder physiology (HP:0012438)2.18390825
85Abnormal number of incisors (HP:0011064)2.16975258
86Generalized aminoaciduria (HP:0002909)2.16376503
87Leukodystrophy (HP:0002415)2.15260538
88Thrombocytosis (HP:0001894)2.12611448
89Chromsome breakage (HP:0040012)2.12187315
90Abnormal trabecular bone morphology (HP:0100671)2.12157876
91Abnormality of the umbilical cord (HP:0010881)2.11082034
92Respiratory failure (HP:0002878)2.10495782
93Adenoma sebaceum (HP:0009720)2.10396140
94Angiofibromas (HP:0010615)2.10396140
95Bone marrow hypocellularity (HP:0005528)2.09335772
96Emotional lability (HP:0000712)2.08140353
97Hypobetalipoproteinemia (HP:0003563)2.07664224
98Rhabdomyolysis (HP:0003201)2.07331584
99Progressive macrocephaly (HP:0004481)2.05564846
100Progressive muscle weakness (HP:0003323)2.05039500
101Increased intramyocellular lipid droplets (HP:0012240)2.03634351
102Absent forearm bone (HP:0003953)2.03115657
103Aplasia involving forearm bones (HP:0009822)2.03115657
104Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00853405
105Abnormality of chromosome stability (HP:0003220)1.98265268
106Hyperglycinemia (HP:0002154)1.97162796
107Increased muscle lipid content (HP:0009058)1.93885895
108Triphalangeal thumb (HP:0001199)1.93548849
109Lethargy (HP:0001254)1.93342330
110Supernumerary spleens (HP:0009799)1.92928844
111Abnormality of serum amino acid levels (HP:0003112)1.91150317
112Abnormal lung lobation (HP:0002101)1.89483188
113Abnormality of monocarboxylic acid metabolism (HP:0010996)1.89218211
114Myelodysplasia (HP:0002863)1.89117553
115Abnormalities of placenta or umbilical cord (HP:0001194)1.88749081
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.88484119
117Glossoptosis (HP:0000162)1.88426748
118Respiratory difficulties (HP:0002880)1.87687680
119CNS hypomyelination (HP:0003429)1.87201252
120Hypoplastic pelvis (HP:0008839)1.86536076
121Abnormal umbilical cord blood vessels (HP:0011403)1.81020315
122Single umbilical artery (HP:0001195)1.81020315
123Abnormality of the fetal cardiovascular system (HP:0010948)1.81020315
124Cleft eyelid (HP:0000625)1.80467279
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79712229
126Dicarboxylic aciduria (HP:0003215)1.79712229
127Exertional dyspnea (HP:0002875)1.78097557
128Opisthotonus (HP:0002179)1.75677338
129Hypoplasia of the capital femoral epiphysis (HP:0003090)1.73768409
130Amniotic constriction ring (HP:0009775)1.69918864
131Abnormality of placental membranes (HP:0011409)1.69918864
132Optic disc pallor (HP:0000543)1.69067584
133Redundant skin (HP:0001582)1.67058545
134Small intestinal stenosis (HP:0012848)1.64347798
135Duodenal stenosis (HP:0100867)1.64347798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.42848712
2VRK25.27148451
3WEE14.25512837
4CDC73.61436275
5EIF2AK13.54942661
6TLK12.92727272
7NME22.90320803
8NEK12.63990229
9STK162.63650605
10TSSK62.45326124
11SRPK12.36114279
12VRK12.31483257
13TTK2.13731170
14NEK22.12397149
15TESK22.04221356
16BCKDK2.04066535
17ACVR1B1.99368709
18SMG11.98644399
19PLK41.92076555
20EIF2AK31.91534292
21PLK11.80532640
22RPS6KB21.70866093
23BRSK21.65054325
24CDK71.58378613
25AURKB1.56652141
26TAF11.55750765
27PASK1.52924852
28RPS6KA41.52071847
29DYRK31.51783002
30AURKA1.51560575
31ATR1.39028747
32SCYL21.37490925
33EPHA21.37349029
34MAP3K81.34613608
35PLK31.30326258
36KDR1.29581435
37MKNK11.25888846
38BRAF1.25185171
39BRSK11.21043651
40FLT31.16591073
41MAP3K111.14606830
42TGFBR11.12291104
43CDK41.05946349
44NME11.05662908
45CCNB11.05284026
46PAK41.05141697
47PDK21.04818335
48IRAK31.04732341
49MAPKAPK31.02817003
50EEF2K1.00051419
51CHEK20.98758610
52PIM20.98454424
53ZAK0.94761138
54MST1R0.94601188
55NUAK10.92898657
56CHEK10.89280793
57STK40.88771340
58MAP2K30.86181805
59MAP3K100.81241918
60STK100.80847683
61CSNK1G30.79753392
62CSNK2A20.78016621
63TESK10.77424134
64LRRK20.76653866
65MKNK20.75788917
66CSNK2A10.75356727
67PAK10.75264524
68CDK80.73810437
69PKN20.73751246
70MAP3K120.68691858
71CDK20.64791827
72ERBB40.64274452
73ILK0.62977904
74TRIM280.62131468
75CSNK1G10.61745860
76PRKCI0.58797499
77ATM0.58786666
78DYRK20.58310503
79LIMK10.58247483
80EIF2AK20.57839216
81ABL20.57216980
82PIM10.56312565
83STK38L0.55760046
84PBK0.55504798
85PDK40.54695769
86PDK30.54695769
87CSNK1A1L0.54244007
88CDK90.53039697
89LATS20.52104610
90AKT20.49432308
91RPS6KA50.48106143
92MAPKAPK50.47959726
93MAP3K30.46926540
94MET0.43396046
95ALK0.43014534
96CDK10.42625762
97LMTK20.42246061
98TAOK20.41444705
99ARAF0.40803614
100DAPK30.40590091
101MAPK110.40404129
102AKT30.39437524
103MAP4K20.39424394
104CDK11A0.38702619
105DAPK10.38586538
106MST40.34462642
107CSNK1E0.33877299
108CSNK1G20.33165313
109CDK140.31246706
110CDK150.29574539
111GRK60.29203911
112CDK180.29011858
113MAP4K10.28643285
114BLK0.27655823
115PIK3CG0.26156876
116MAP2K70.25230325
117CDK190.25072451
118OBSCN0.21468256
119PNCK0.21440361
120PRKDC0.20017408
121CLK10.19197868
122MAP3K50.18888410
123MELK0.18447101
124FGFR10.17927395
125RPS6KC10.17796014

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.68868438
2Ribosome_Homo sapiens_hsa030104.08409607
3Mismatch repair_Homo sapiens_hsa034303.92802195
4Proteasome_Homo sapiens_hsa030503.76839888
5RNA polymerase_Homo sapiens_hsa030203.17401236
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.06228378
7Spliceosome_Homo sapiens_hsa030402.95409012
8One carbon pool by folate_Homo sapiens_hsa006702.85328276
9Base excision repair_Homo sapiens_hsa034102.74328786
10Nucleotide excision repair_Homo sapiens_hsa034202.62823575
11RNA transport_Homo sapiens_hsa030132.61909278
12Pyrimidine metabolism_Homo sapiens_hsa002402.59449471
13Homologous recombination_Homo sapiens_hsa034402.57398405
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49612192
15Cell cycle_Homo sapiens_hsa041101.99828192
16Non-homologous end-joining_Homo sapiens_hsa034501.60961752
17Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60935457
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59105763
19Fanconi anemia pathway_Homo sapiens_hsa034601.58313514
20RNA degradation_Homo sapiens_hsa030181.53181913
21Folate biosynthesis_Homo sapiens_hsa007901.52307957
22Parkinsons disease_Homo sapiens_hsa050121.50517814
23Biosynthesis of amino acids_Homo sapiens_hsa012301.49684180
24Cysteine and methionine metabolism_Homo sapiens_hsa002701.48699692
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39709269
26Oxidative phosphorylation_Homo sapiens_hsa001901.39607078
27Basal transcription factors_Homo sapiens_hsa030221.38293457
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29485011
29Purine metabolism_Homo sapiens_hsa002301.29149963
30Carbon metabolism_Homo sapiens_hsa012001.29065846
31Huntingtons disease_Homo sapiens_hsa050161.27754841
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.24379919
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22969811
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.22400268
35Sulfur relay system_Homo sapiens_hsa041221.15123355
36Selenocompound metabolism_Homo sapiens_hsa004501.12470665
37mRNA surveillance pathway_Homo sapiens_hsa030151.10560924
38Pentose phosphate pathway_Homo sapiens_hsa000301.08865208
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08569581
40Protein export_Homo sapiens_hsa030601.08065904
41p53 signaling pathway_Homo sapiens_hsa041151.05894988
42Systemic lupus erythematosus_Homo sapiens_hsa053221.05681515
43Glutathione metabolism_Homo sapiens_hsa004800.93507605
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91380800
45Pyruvate metabolism_Homo sapiens_hsa006200.90992145
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89660208
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88666075
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85364447
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85194697
50Epstein-Barr virus infection_Homo sapiens_hsa051690.83417215
51Sulfur metabolism_Homo sapiens_hsa009200.80253932
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77948699
53Alzheimers disease_Homo sapiens_hsa050100.67330972
54Vitamin B6 metabolism_Homo sapiens_hsa007500.66300984
55Fructose and mannose metabolism_Homo sapiens_hsa000510.64213150
56Propanoate metabolism_Homo sapiens_hsa006400.63195591
57Metabolic pathways_Homo sapiens_hsa011000.58148001
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57716590
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57119795
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55471761
61Steroid biosynthesis_Homo sapiens_hsa001000.54635943
62Oocyte meiosis_Homo sapiens_hsa041140.53497128
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51223606
64Galactose metabolism_Homo sapiens_hsa000520.49991911
65Viral carcinogenesis_Homo sapiens_hsa052030.49555815
66Arginine and proline metabolism_Homo sapiens_hsa003300.49399396
67Fatty acid degradation_Homo sapiens_hsa000710.47625313
68Thyroid cancer_Homo sapiens_hsa052160.45536683
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42556113
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.40916788
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39319466
72Herpes simplex infection_Homo sapiens_hsa051680.37886339
73Peroxisome_Homo sapiens_hsa041460.36438330
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35801902
75Antigen processing and presentation_Homo sapiens_hsa046120.33653038
76Phenylalanine metabolism_Homo sapiens_hsa003600.33207243
77HTLV-I infection_Homo sapiens_hsa051660.30740206
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30342409
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28737408
80Vibrio cholerae infection_Homo sapiens_hsa051100.28138253
81Tyrosine metabolism_Homo sapiens_hsa003500.27826505
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27330321
83Legionellosis_Homo sapiens_hsa051340.27327899
84beta-Alanine metabolism_Homo sapiens_hsa004100.27229704
85Vitamin digestion and absorption_Homo sapiens_hsa049770.26825255
86Bladder cancer_Homo sapiens_hsa052190.23878508
87Tryptophan metabolism_Homo sapiens_hsa003800.23809429
88Arginine biosynthesis_Homo sapiens_hsa002200.23557586
89Butanoate metabolism_Homo sapiens_hsa006500.22508782
90Basal cell carcinoma_Homo sapiens_hsa052170.21759375
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20480711
92Cardiac muscle contraction_Homo sapiens_hsa042600.19067811
93Alcoholism_Homo sapiens_hsa050340.19065595
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18645091
95N-Glycan biosynthesis_Homo sapiens_hsa005100.17954376
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16886153
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15066109
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14371278
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.13567431
100Retinol metabolism_Homo sapiens_hsa008300.12393907
101Fat digestion and absorption_Homo sapiens_hsa049750.12363066
102Chemical carcinogenesis_Homo sapiens_hsa052040.12144011
103Fatty acid metabolism_Homo sapiens_hsa012120.10929795
104Fatty acid elongation_Homo sapiens_hsa000620.10680068
105Arachidonic acid metabolism_Homo sapiens_hsa005900.09018120
106Apoptosis_Homo sapiens_hsa042100.07333844
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07162894
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.05502314
109Lysine degradation_Homo sapiens_hsa003100.05478005
110Hippo signaling pathway_Homo sapiens_hsa043900.05099259

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