STON1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)5.84356892
2collagen fibril organization (GO:0030199)5.24984446
3neuron projection extension involved in neuron projection guidance (GO:1902284)5.11238564
4axon extension involved in axon guidance (GO:0048846)5.11238564
5cell adhesion mediated by integrin (GO:0033627)4.96381929
6endodermal cell differentiation (GO:0035987)4.78320957
7protein heterotrimerization (GO:0070208)4.48769813
8glomerular basement membrane development (GO:0032836)4.38349918
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.16461151
10bone trabecula formation (GO:0060346)4.11497347
11basement membrane organization (GO:0071711)4.05528613
12plasma membrane repair (GO:0001778)4.04740308
13positive regulation of endothelial cell apoptotic process (GO:2000353)3.96312682
14skin morphogenesis (GO:0043589)3.90326105
15mesenchymal-epithelial cell signaling (GO:0060638)3.88689505
16sequestering of extracellular ligand from receptor (GO:0035581)3.86349077
17vascular endothelial growth factor signaling pathway (GO:0038084)3.83218245
18wound healing, spreading of epidermal cells (GO:0035313)3.80528544
19hippo signaling (GO:0035329)3.74221015
20negative regulation of fatty acid transport (GO:2000192)3.72702976
21endocardial cushion development (GO:0003197)3.71854539
22glomerular visceral epithelial cell development (GO:0072015)3.67042067
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.65405974
24collagen metabolic process (GO:0032963)3.62845375
25paraxial mesoderm development (GO:0048339)3.59928007
26cell migration involved in sprouting angiogenesis (GO:0002042)3.59570807
27collagen catabolic process (GO:0030574)3.59034306
28kidney mesenchyme development (GO:0072074)3.57693868
29limb bud formation (GO:0060174)3.55544968
30metanephric mesenchyme development (GO:0072075)3.53547652
31multicellular organismal macromolecule metabolic process (GO:0044259)3.44727367
32apoptotic cell clearance (GO:0043277)3.43799997
33cellular response to vitamin D (GO:0071305)3.40435347
34lateral sprouting from an epithelium (GO:0060601)3.37331156
35retina vasculature morphogenesis in camera-type eye (GO:0061299)3.35922908
36multicellular organismal catabolic process (GO:0044243)3.33204670
37artery development (GO:0060840)3.33137866
38cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.32833702
39glomerular epithelial cell development (GO:0072310)3.32593882
40epithelial cell-cell adhesion (GO:0090136)3.31157231
41mesodermal cell differentiation (GO:0048333)3.29760655
42renal filtration (GO:0097205)3.26951149
43multicellular organismal metabolic process (GO:0044236)3.26261817
44extracellular matrix disassembly (GO:0022617)3.24714018
45lung-associated mesenchyme development (GO:0060484)3.24367490
46lymphangiogenesis (GO:0001946)3.20033993
47branching involved in salivary gland morphogenesis (GO:0060445)3.19225820
48craniofacial suture morphogenesis (GO:0097094)3.19034253
49cell-substrate junction assembly (GO:0007044)3.18732171
50positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.16730280
51positive regulation of epithelial to mesenchymal transition (GO:0010718)3.15929540
52cellular response to vitamin (GO:0071295)3.14673097
53negative regulation of chondrocyte differentiation (GO:0032331)3.12883266
54polarized epithelial cell differentiation (GO:0030859)3.12578274
55regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.09476386
56protein localization to cell surface (GO:0034394)3.05911213
57substrate adhesion-dependent cell spreading (GO:0034446)3.05089616
58substrate-dependent cell migration (GO:0006929)3.03502242
59wound healing, spreading of cells (GO:0044319)3.03456315
60insulin-like growth factor receptor signaling pathway (GO:0048009)3.02697185
61epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.02037741
62regulation of non-canonical Wnt signaling pathway (GO:2000050)2.97391188
63G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.96561329
64regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.95174893
65blood vessel endothelial cell migration (GO:0043534)2.95125404
66regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.94686846
67planar cell polarity pathway involved in neural tube closure (GO:0090179)2.93482213
68adherens junction assembly (GO:0034333)2.91773855
69regulation of tight junction assembly (GO:2000810)2.91372646
70myelination in peripheral nervous system (GO:0022011)2.90790032
71peripheral nervous system axon ensheathment (GO:0032292)2.90790032
72establishment of planar polarity (GO:0001736)2.89497581
73establishment of tissue polarity (GO:0007164)2.89497581
74cell proliferation involved in metanephros development (GO:0072203)2.89385786
75cell migration involved in heart development (GO:0060973)2.89055905
76negative regulation of smooth muscle cell migration (GO:0014912)2.88072181
77dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.86610470
78presynaptic membrane assembly (GO:0097105)2.86131681
79non-canonical Wnt signaling pathway (GO:0035567)2.84936361
80somite development (GO:0061053)2.83590178
81prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.83079768
82outer ear morphogenesis (GO:0042473)2.82151946
83endothelial cell morphogenesis (GO:0001886)2.81885154
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81695311
85negative regulation of axon guidance (GO:1902668)2.79614321
86regulation of hippo signaling (GO:0035330)2.77351348
87regulation of axon guidance (GO:1902667)2.76729536
88regulation of transforming growth factor beta2 production (GO:0032909)2.75528214
89hemidesmosome assembly (GO:0031581)2.75355989
90positive regulation of macrophage activation (GO:0043032)2.74614630
91mesenchyme morphogenesis (GO:0072132)2.74418266
92neuronal stem cell maintenance (GO:0097150)2.73414723
93embryonic cranial skeleton morphogenesis (GO:0048701)2.72711036
94camera-type eye morphogenesis (GO:0048593)2.71493928
95response to fluid shear stress (GO:0034405)2.70365325
96glomerulus development (GO:0032835)2.69742730
97otic vesicle formation (GO:0030916)2.69392659
98glomerular filtration (GO:0003094)2.69009534
99regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.67332801
100mesenchyme development (GO:0060485)2.67118405
101positive regulation of cartilage development (GO:0061036)2.65203198
102calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.64606630
103dermatan sulfate biosynthetic process (GO:0030208)2.64255065
104positive regulation of gastrulation (GO:2000543)2.64254335
105positive regulation of blood vessel endothelial cell migration (GO:0043536)2.64244167
106appendage development (GO:0048736)2.63502801
107limb development (GO:0060173)2.63502801
108Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.63458699
109presynaptic membrane organization (GO:0097090)2.60720885
110relaxation of smooth muscle (GO:0044557)2.60581858
111midbrain development (GO:0030901)2.60168132
112extracellular matrix organization (GO:0030198)2.59913129
113extracellular structure organization (GO:0043062)2.59014840
114regulation of cartilage development (GO:0061035)2.58784170
115positive regulation of mesenchymal cell proliferation (GO:0002053)2.57554297
116retinal ganglion cell axon guidance (GO:0031290)2.56296126
117cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.56072355
118positive regulation of extracellular matrix organization (GO:1903055)2.55950732
119regulation of establishment of planar polarity (GO:0090175)2.55637708
120focal adhesion assembly (GO:0048041)2.54411371
121cell-substrate adherens junction assembly (GO:0007045)2.54411371
122smooth muscle tissue development (GO:0048745)2.54033078
123regulation of axon extension involved in axon guidance (GO:0048841)2.53216417
124mesenchymal cell proliferation (GO:0010463)2.52965978
125extracellular matrix assembly (GO:0085029)2.52724011
126notochord development (GO:0030903)2.52625714
127cGMP-mediated signaling (GO:0019934)2.52309085
128regulation of chondrocyte differentiation (GO:0032330)2.52262534
129negative regulation of cartilage development (GO:0061037)2.51601224
130tongue development (GO:0043586)2.51431820
131blood vessel maturation (GO:0001955)2.51408456
132stress fiber assembly (GO:0043149)2.51043115
133regulation of SMAD protein import into nucleus (GO:0060390)2.50782220
134peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.50733486
135axis elongation (GO:0003401)2.50649285
136embryonic camera-type eye development (GO:0031076)2.50190039
137positive regulation of p38MAPK cascade (GO:1900745)2.49330091
138negative chemotaxis (GO:0050919)2.48385685
139chondrocyte development (GO:0002063)2.47471347
140positive regulation of stem cell differentiation (GO:2000738)2.46926550
141extracellular fibril organization (GO:0043206)2.46897915
142cranial suture morphogenesis (GO:0060363)2.46051743
143urinary tract smooth muscle contraction (GO:0014848)2.45087058
144kidney morphogenesis (GO:0060993)2.44102824
145radial glial cell differentiation (GO:0060019)2.43617425
146Notch signaling involved in heart development (GO:0061314)2.43218717
147inner ear receptor stereocilium organization (GO:0060122)2.41744076
148negative regulation of protein localization to cell surface (GO:2000009)2.41516762
149negative regulation of axon extension involved in axon guidance (GO:0048843)2.41066852
150convergent extension (GO:0060026)2.40949202
151regulation of integrin-mediated signaling pathway (GO:2001044)2.39961825
152male genitalia development (GO:0030539)2.39579087
153positive regulation of catenin import into nucleus (GO:0035413)2.39411345
154vasculature development (GO:0001944)2.38440995
155regulation of mesenchymal cell proliferation (GO:0010464)2.38231300
156cellular response to cholesterol (GO:0071397)2.36153680
157dermatan sulfate metabolic process (GO:0030205)2.35767568
158cell surface receptor signaling pathway involved in heart development (GO:0061311)2.35576410
159embryonic foregut morphogenesis (GO:0048617)2.34027440
160postsynaptic membrane organization (GO:0001941)2.33255174
161cardiac myofibril assembly (GO:0055003)2.33047440
162regulation of chemokine-mediated signaling pathway (GO:0070099)2.32121491
163fibroblast migration (GO:0010761)2.30191937
164endocardial cushion morphogenesis (GO:0003203)2.28829924
165cell differentiation involved in metanephros development (GO:0072202)2.27783896
166nonmotile primary cilium assembly (GO:0035058)2.27422727
167dorsal/ventral axis specification (GO:0009950)2.27346424
168smooth muscle contraction (GO:0006939)2.25174900
169ventricular septum development (GO:0003281)2.24995323
170neural crest cell development (GO:0014032)2.24246966
171hindbrain development (GO:0030902)2.23946816
172cell-cell signaling involved in cell fate commitment (GO:0045168)2.23919726
173regulation of smoothened signaling pathway (GO:0008589)2.23892447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.57137019
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.31148691
3RARG_19884340_ChIP-ChIP_MEFs_Mouse4.01761081
4GBX2_23144817_ChIP-Seq_PC3_Human3.28451340
5EZH2_22144423_ChIP-Seq_EOC_Human3.02369756
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.79758175
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.61728956
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.56379705
9CLOCK_20551151_ChIP-Seq_293T_Human2.55783370
10ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.41516105
11CJUN_26792858_Chip-Seq_BT549_Human2.38115344
12* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.37024255
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.36213208
14EP300_21415370_ChIP-Seq_HL-1_Mouse2.34046700
15* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.18766098
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.15862886
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.14624245
18EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.14444857
19CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11509857
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.07000800
21BRD4_25478319_ChIP-Seq_HGPS_Human2.06799930
22ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03562219
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.93835381
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91858138
25PPAR_26484153_Chip-Seq_NCI-H1993_Human1.90302757
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.88827611
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86056881
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.82413475
29HIF1A_21447827_ChIP-Seq_MCF-7_Human1.80744353
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.80489276
31P300_19829295_ChIP-Seq_ESCs_Human1.80310962
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.78040629
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77954330
34SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.77526342
35SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.77526342
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.76759884
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74763936
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73852001
39SMAD4_21799915_ChIP-Seq_A2780_Human1.72585120
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71362807
41NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71362807
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69095681
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.68008921
44* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64584726
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64449489
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.64388053
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.63915786
48FUS_26573619_Chip-Seq_HEK293_Human1.62709706
49TP53_18474530_ChIP-ChIP_U2OS_Human1.62639014
50* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.62604521
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.62569372
52CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62482127
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62436502
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59932111
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.59750540
56IGF1R_20145208_ChIP-Seq_DFB_Human1.59324244
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.58629477
58TP53_16413492_ChIP-PET_HCT116_Human1.58466172
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57554629
60EWS_26573619_Chip-Seq_HEK293_Human1.56344145
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.56210835
62TAF15_26573619_Chip-Seq_HEK293_Human1.55737765
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.53874373
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.52498806
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50996327
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.48131391
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47699651
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46642629
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44787571
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44699852
71ISL1_27105846_Chip-Seq_CPCs_Mouse1.43381898
72VDR_22108803_ChIP-Seq_LS180_Human1.42978728
73RNF2_27304074_Chip-Seq_ESCs_Mouse1.42460860
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42169734
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40583803
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40481724
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.38391888
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37600064
79TBX3_20139965_ChIP-Seq_MESCs_Mouse1.37108265
80TBX3_20139965_ChIP-Seq_ESCs_Mouse1.36875137
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36129593
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36092292
83* TBX20_22328084_ChIP-Seq_HEART_Mouse1.33255659
84* TBX20_22080862_ChIP-Seq_HEART_Mouse1.33255659
85STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31720088
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.31620901
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31355620
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31044209
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30966685
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.30904102
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.30772369
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30710049
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.29690917
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.29079575
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27088424
96AR_25329375_ChIP-Seq_VCAP_Human1.26832791
97RNF2_27304074_Chip-Seq_NSC_Mouse1.26491623
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26187077
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26187077
100AR_21572438_ChIP-Seq_LNCaP_Human1.25734974
101UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25483791
102STAT3_23295773_ChIP-Seq_U87_Human1.25066242
103KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.24766663
104JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24662740
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.24584189
106JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24518667
107NANOG_18555785_Chip-Seq_ESCs_Mouse1.23268046
108CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21147591
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20831235
110NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20457076
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20243585
112SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20087607
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19990728
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18770006
115YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17986758
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17503716
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17352294
118KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16933491
119SOX2_20726797_ChIP-Seq_SW620_Human1.16316317
120BCAT_22108803_ChIP-Seq_LS180_Human1.15731914
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15296937
122TCF4_23295773_ChIP-Seq_U87_Human1.15267066
123AHR_22903824_ChIP-Seq_MCF-7_Human1.14675179
124SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.14572000
125ZNF274_21170338_ChIP-Seq_K562_Hela1.13256070
126TP53_23651856_ChIP-Seq_MEFs_Mouse1.12643825
127MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12553959
128EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11485113
129RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11485113
130FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11449914
131SOX2_21211035_ChIP-Seq_LN229_Gbm1.11170269
132LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11061937
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.10706334
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.10165947
135TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09453056
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08823033
137RUNX2_22187159_ChIP-Seq_PCA_Human1.07879967
138CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.07837523
139* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07418934
140TP53_22127205_ChIP-Seq_IMR90_Human1.07225634
141PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06770072
142TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05429726
143DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04635279
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03645084
145ARNT_22903824_ChIP-Seq_MCF-7_Human1.03244441
146KLF5_25053715_ChIP-Seq_YYC3_Human0.99096616
147ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98794857
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97908984
149SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97219600
150ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.95959937
151ATF3_27146783_Chip-Seq_COLON_Human0.95783713
152RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95615768
153KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95221486
154TCF4_18268006_ChIP-ChIP_LS174T_Human0.95145710
155SMAD3_21741376_ChIP-Seq_HESCs_Human0.95111642
156CDX2_20551321_ChIP-Seq_CACO-2_Human0.94974321
157KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94719202
158SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93927406
159SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93291082
160KDM2B_26808549_Chip-Seq_K562_Human0.93151898
161CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91926981
162TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91878859
163LXR_22158963_ChIP-Seq_LIVER_Mouse0.91026220
164TP63_23658742_ChIP-Seq_EP156T_Human0.90764273
165PIAS1_25552417_ChIP-Seq_VCAP_Human0.90203900
166SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87248016
167RXR_22108803_ChIP-Seq_LS180_Human0.87229958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.34788038
2MP0005623_abnormal_meninges_morphology4.11265369
3MP0005503_abnormal_tendon_morphology4.10631047
4MP0005275_abnormal_skin_tensile3.74484139
5MP0003705_abnormal_hypodermis_morpholog3.71014605
6MP0003279_aneurysm3.55698138
7MP0004272_abnormal_basement_membrane3.33137558
8MP0003136_yellow_coat_color3.21714438
9MP0001958_emphysema2.76448825
10MP0009384_cardiac_valve_regurgitation2.70687030
11MP0010030_abnormal_orbit_morphology2.34781421
12MP0003566_abnormal_cell_adhesion2.34430758
13MP0003091_abnormal_cell_migration2.15106607
14MP0010352_gastrointestinal_tract_polyps2.13332714
15MP0005508_abnormal_skeleton_morphology2.00401084
16MP0002938_white_spotting1.99340496
17MP0003385_abnormal_body_wall1.98726524
18MP0005023_abnormal_wound_healing1.92381192
19MP0006054_spinal_hemorrhage1.90831994
20MP0005257_abnormal_intraocular_pressure1.87327450
21MP0010368_abnormal_lymphatic_system1.83234478
22MP0009250_abnormal_appendicular_skeleto1.77421761
23MP0002295_abnormal_pulmonary_circulatio1.77312276
24MP0000767_abnormal_smooth_muscle1.74092402
25MP0001293_anophthalmia1.69166214
26MP0000778_abnormal_nervous_system1.66148216
27MP0000733_abnormal_muscle_development1.64507545
28MP0009053_abnormal_anal_canal1.61850371
29MP0000534_abnormal_ureter_morphology1.61753088
30MP0002060_abnormal_skin_morphology1.59807173
31MP0003941_abnormal_skin_development1.59759089
32MP0005670_abnormal_white_adipose1.58673854
33MP0003045_fibrosis1.55704524
34MP0009780_abnormal_chondrocyte_physiolo1.53869361
35MP0002896_abnormal_bone_mineralization1.53087617
36MP0003942_abnormal_urinary_system1.46112405
37MP0002108_abnormal_muscle_morphology1.44135931
38MP0002234_abnormal_pharynx_morphology1.44020306
39MP0002168_other_aberrant_phenotype1.42638554
40MP0003115_abnormal_respiratory_system1.37315319
41MP0002282_abnormal_trachea_morphology1.33356620
42MP0001299_abnormal_eye_distance/1.32466732
43MP0005076_abnormal_cell_differentiation1.30404938
44MP0000428_abnormal_craniofacial_morphol1.27497909
45MP0005187_abnormal_penis_morphology1.27188928
46MP0000537_abnormal_urethra_morphology1.26185673
47MP0003283_abnormal_digestive_organ1.25631564
48MP0001348_abnormal_lacrimal_gland1.22247723
49MP0000462_abnormal_digestive_system1.21359229
50MP0004215_abnormal_myocardial_fiber1.19377389
51MP0002877_abnormal_melanocyte_morpholog1.18758357
52MP0004084_abnormal_cardiac_muscle1.18426570
53MP0001879_abnormal_lymphatic_vessel1.17864643
54MP0000163_abnormal_cartilage_morphology1.17396015
55MP0002932_abnormal_joint_morphology1.17301672
56MP0003755_abnormal_palate_morphology1.15667299
57MP0000383_abnormal_hair_follicle1.15081977
58MP0002115_abnormal_skeleton_extremities1.13102283
59MP0003935_abnormal_craniofacial_develop1.11236214
60MP0001286_abnormal_eye_development1.11191428
61MP0002128_abnormal_blood_circulation1.10588624
62MP0000566_synostosis1.10207238
63MP0002249_abnormal_larynx_morphology1.09828699
64MP0003300_gastrointestinal_ulcer1.09663788
65MP0003937_abnormal_limbs/digits/tail_de1.08974717
66MP0003938_abnormal_ear_development1.08791113
67MP0006276_abnormal_autonomic_nervous1.08308897
68MP0005620_abnormal_muscle_contractility1.07658287
69MP0000432_abnormal_head_morphology1.05670189
70MP0000230_abnormal_systemic_arterial1.03161170
71MP0005367_renal/urinary_system_phenotyp1.02795860
72MP0000516_abnormal_urinary_system1.02795860
73MP0001243_abnormal_dermal_layer1.02763571
74MP0002113_abnormal_skeleton_development1.02410493
75MP0000026_abnormal_inner_ear1.02339482
76MP0005390_skeleton_phenotype1.00781823
77MP0001614_abnormal_blood_vessel1.00623357
78MP0002925_abnormal_cardiovascular_devel0.99233739
79MP0003119_abnormal_digestive_system0.98928356
80MP0002697_abnormal_eye_size0.98845043
81MP0006292_abnormal_olfactory_placode0.97891018
82MP0000750_abnormal_muscle_regeneration0.97845373
83MP0001915_intracranial_hemorrhage0.97689647
84MP0006138_congestive_heart_failure0.97304195
85MP0002638_abnormal_pupillary_reflex0.97260759
86MP0004134_abnormal_chest_morphology0.97156148
87MP0002933_joint_inflammation0.96935319
88MP0005248_abnormal_Harderian_gland0.96817017
89MP0000569_abnormal_digit_pigmentation0.96247253
90MP0000049_abnormal_middle_ear0.95199531
91MP0008775_abnormal_heart_ventricle0.95195780
92MP0006072_abnormal_retinal_apoptosis0.93781579
93MP0002653_abnormal_ependyma_morphology0.93774734
94MP0004036_abnormal_muscle_relaxation0.93701513
95MP0000631_abnormal_neuroendocrine_gland0.92614301
96MP0005253_abnormal_eye_physiology0.92521203
97MP0003878_abnormal_ear_physiology0.91461226
98MP0005377_hearing/vestibular/ear_phenot0.91461226
99MP0000751_myopathy0.91384225
100MP0005391_vision/eye_phenotype0.90282764
101MP0002233_abnormal_nose_morphology0.90160488
102MP0001984_abnormal_olfaction0.89154419
103MP0001177_atelectasis0.88964358
104MP0001542_abnormal_bone_strength0.88282293
105MP0004133_heterotaxia0.88115131
106MP0002116_abnormal_craniofacial_bone0.88033444
107MP0004885_abnormal_endolymph0.87898254
108MP0002109_abnormal_limb_morphology0.87414633
109MP0004233_abnormal_muscle_weight0.87103692
110MP0002998_abnormal_bone_remodeling0.86811472
111MP0009379_abnormal_foot_pigmentation0.86675884
112MP0003950_abnormal_plasma_membrane0.86050239
113MP0002751_abnormal_autonomic_nervous0.83438555
114MP0000013_abnormal_adipose_tissue0.83133684
115MP0002111_abnormal_tail_morphology0.82810015
116MP0003252_abnormal_bile_duct0.81619084
117MP0000762_abnormal_tongue_morphology0.81241351
118MP0000858_altered_metastatic_potential0.80896901
119MP0001324_abnormal_eye_pigmentation0.80745692
120MP0010630_abnormal_cardiac_muscle0.79428730
121MP0000647_abnormal_sebaceous_gland0.79018704
122MP0001849_ear_inflammation0.78821655
123MP0001346_abnormal_lacrimal_gland0.78486848
124MP0010386_abnormal_urinary_bladder0.78420791
125MP0003880_abnormal_central_pattern0.78405260
126MP0003890_abnormal_embryonic-extraembry0.77369971
127MP0005197_abnormal_uvea_morphology0.77368569
128MP0004087_abnormal_muscle_fiber0.77367155
129MP0002089_abnormal_postnatal_growth/wei0.76146718
130MP0008789_abnormal_olfactory_epithelium0.73469228
131MP0002254_reproductive_system_inflammat0.73298617
132MP0000749_muscle_degeneration0.72449358
133MP0005195_abnormal_posterior_eye0.72137428
134MP0001175_abnormal_lung_morphology0.71909868
135MP0002092_abnormal_eye_morphology0.71163993
136MP0005171_absent_coat_pigmentation0.70973164
137MP0000266_abnormal_heart_morphology0.69933676
138MP0005193_abnormal_anterior_eye0.69327029
139MP0005595_abnormal_vascular_smooth0.67026776
140MP0004197_abnormal_fetal_growth/weight/0.66265551
141MP0003448_altered_tumor_morphology0.64914913
142MP0003795_abnormal_bone_structure0.64491996
143MP0003567_abnormal_fetal_cardiomyocyte0.64457766
144MP0009278_abnormal_bone_marrow0.64108828
145MP0000003_abnormal_adipose_tissue0.63719114

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.34383069
2Premature rupture of membranes (HP:0001788)6.75593830
3Shallow orbits (HP:0000586)4.86819422
4Ankle contracture (HP:0006466)4.56121831
5Aortic dissection (HP:0002647)4.52049130
6Atrophic scars (HP:0001075)4.20787325
7Broad metatarsal (HP:0001783)4.05506350
8Peritonitis (HP:0002586)3.92097775
9Aortic aneurysm (HP:0004942)3.87474103
10Cerebral aneurysm (HP:0004944)3.80604226
11Cervical subluxation (HP:0003308)3.70662722
12Fragile skin (HP:0001030)3.65500348
13Abnormality of dentin (HP:0010299)3.55005386
14Soft skin (HP:0000977)3.53120854
15Neonatal short-limb short stature (HP:0008921)3.40007000
16Bladder diverticulum (HP:0000015)3.33010462
17Mitral valve prolapse (HP:0001634)3.13760438
18Wrist flexion contracture (HP:0001239)3.10646181
19Dilatation of the ascending aorta (HP:0005111)3.09796452
20Neoplasm of the heart (HP:0100544)3.07559445
21Blue sclerae (HP:0000592)2.96178388
22Genu recurvatum (HP:0002816)2.92557405
23Wormian bones (HP:0002645)2.86236046
24Increased connective tissue (HP:0009025)2.85668316
25Spinal rigidity (HP:0003306)2.81340597
26Septo-optic dysplasia (HP:0100842)2.76618913
27Hypoplasia of the iris (HP:0007676)2.75433357
28Coronal craniosynostosis (HP:0004440)2.73430178
29Vascular tortuosity (HP:0004948)2.67663981
30Camptodactyly of toe (HP:0001836)2.63407129
31Cutaneous finger syndactyly (HP:0010554)2.61913782
32Vertebral compression fractures (HP:0002953)2.59334298
33Biconcave vertebral bodies (HP:0004586)2.54683363
34Aneurysm (HP:0002617)2.50249270
35Tibial bowing (HP:0002982)2.50058505
36Type 1 muscle fiber predominance (HP:0003803)2.48997415
37Vitreoretinal degeneration (HP:0000655)2.43191687
38Preaxial foot polydactyly (HP:0001841)2.42527260
39Pulmonary artery stenosis (HP:0004415)2.41063638
40Ulnar bowing (HP:0003031)2.40354085
41Follicular hyperkeratosis (HP:0007502)2.40092190
42Short nail (HP:0001799)2.39378100
43Increased corneal curvature (HP:0100692)2.38216614
44Keratoconus (HP:0000563)2.38216614
45Osteolytic defects of the hand bones (HP:0009699)2.37874755
46Osteolytic defects of the phalanges of the hand (HP:0009771)2.37874755
47Wide anterior fontanel (HP:0000260)2.37544482
48Mesomelia (HP:0003027)2.37312737
49Abnormality of the acetabulum (HP:0003170)2.34361537
50Bowel diverticulosis (HP:0005222)2.30962403
51Hyperextensible skin (HP:0000974)2.30179430
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.29959914
53Short 4th metacarpal (HP:0010044)2.29959914
54Deviation of the hallux (HP:0010051)2.28481996
55Syringomyelia (HP:0003396)2.28151596
56Spinal cord lesions (HP:0100561)2.28151596
57Arterial tortuosity (HP:0005116)2.26871980
58Abnormal delivery (HP:0001787)2.24342826
59Abnormality of the parietal bone (HP:0002696)2.23543840
60Overgrowth (HP:0001548)2.22226253
61Optic nerve hypoplasia (HP:0000609)2.19557518
62Partial duplication of the phalanx of hand (HP:0009999)2.19036035
63Cutaneous syndactyly (HP:0012725)2.17599929
64Joint laxity (HP:0001388)2.16934965
65Ectopia lentis (HP:0001083)2.15753974
66Bell-shaped thorax (HP:0001591)2.15364494
67Hallux valgus (HP:0001822)2.15169976
68Chorioretinal atrophy (HP:0000533)2.15011166
69Bilateral microphthalmos (HP:0007633)2.14500305
70Thin bony cortex (HP:0002753)2.14224843
71Femoral bowing (HP:0002980)2.11448760
72Infantile muscular hypotonia (HP:0008947)2.10956013
73Flexion contracture of toe (HP:0005830)2.09618144
74Joint contractures involving the joints of the feet (HP:0100492)2.09618144
75Elbow flexion contracture (HP:0002987)2.08125191
76Abdominal situs inversus (HP:0003363)2.06575170
77Abnormality of abdominal situs (HP:0011620)2.06575170
78Fibular hypoplasia (HP:0003038)2.06167196
79Knee flexion contracture (HP:0006380)2.04500437
80Hip contracture (HP:0003273)2.03344667
81Radial bowing (HP:0002986)2.02656576
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02005881
83Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01683280
84Spondylolisthesis (HP:0003302)2.01152572
85Abnormality of the peritoneum (HP:0002585)2.00767249
86Abnormality of the diencephalon (HP:0010662)1.99982985
87Broad long bones (HP:0005622)1.99709228
88Anophthalmia (HP:0000528)1.99354685
89Partial duplication of thumb phalanx (HP:0009944)1.98478030
90Aortic regurgitation (HP:0001659)1.96302589
91Bowing of the arm (HP:0006488)1.94889178
92Bowed forearm bones (HP:0003956)1.94889178
93Focal segmental glomerulosclerosis (HP:0000097)1.93300961
94Scapular winging (HP:0003691)1.92302905
95Lymphangioma (HP:0100764)1.91579197
96Increased density of long bones (HP:0006392)1.91224452
97Short hallux (HP:0010109)1.90740079
98Aplasia/Hypoplasia of the hallux (HP:0008362)1.90557850
99Mildly elevated creatine phosphokinase (HP:0008180)1.89001769
100Increased variability in muscle fiber diameter (HP:0003557)1.87977350
101Abnormality of the 4th metacarpal (HP:0010012)1.87574463
102Hypoplastic ischia (HP:0003175)1.86935785
103Morphological abnormality of the middle ear (HP:0008609)1.86472480
104Broad phalanx (HP:0006009)1.85088217
105Aplasia involving bones of the extremities (HP:0009825)1.84425016
106Aplasia involving bones of the upper limbs (HP:0009823)1.84425016
107Aplasia of the phalanges of the hand (HP:0009802)1.84425016
108Buphthalmos (HP:0000557)1.84114279
109Midline defect of the nose (HP:0004122)1.84052029
110Bicornuate uterus (HP:0000813)1.83804239
111Maternal diabetes (HP:0009800)1.82120693
112Broad ribs (HP:0000885)1.81015659
113Right ventricular cardiomyopathy (HP:0011663)1.80086086
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.78971755
115Choanal stenosis (HP:0000452)1.78430814
116Omphalocele (HP:0001539)1.78222410
117Synostosis of carpal bones (HP:0005048)1.78120955
118Osteoarthritis (HP:0002758)1.77928738
119Limited hip movement (HP:0008800)1.77763939
120Tarsal synostosis (HP:0008368)1.77609817
121Renal dysplasia (HP:0000110)1.77603386
122Upper limb amyotrophy (HP:0009129)1.77331218
123Distal upper limb amyotrophy (HP:0007149)1.77331218
124Asymmetry of the thorax (HP:0001555)1.77189956
125Turricephaly (HP:0000262)1.76659793
126Muscle fiber splitting (HP:0003555)1.75549214
127Breech presentation (HP:0001623)1.75121000
128Mitral regurgitation (HP:0001653)1.74683504
129True hermaphroditism (HP:0010459)1.74188359
130Split foot (HP:0001839)1.73645921
131Venous abnormality (HP:0002624)1.73276460
132Venous insufficiency (HP:0005293)1.71095681
133Abnormality of the distal phalanx of the thumb (HP:0009617)1.71091711
134Abnormality of the renal medulla (HP:0100957)1.70612056
135Alopecia of scalp (HP:0002293)1.70326786
136Ulnar claw (HP:0001178)1.69146071
137Absent frontal sinuses (HP:0002688)1.68890343
138Hypoplasia of the ulna (HP:0003022)1.68818069
139Spinal cord compression (HP:0002176)1.67481132
140Coxa vara (HP:0002812)1.67468446
141Bifid tongue (HP:0010297)1.67351503
142Abnormality of the middle phalanges of the toes (HP:0010183)1.67147409
143Abnormality of the pubic bones (HP:0003172)1.67073644
144Abnormality of the ischium (HP:0003174)1.67046789
145Broad toe (HP:0001837)1.66901945
146Tracheomalacia (HP:0002779)1.66786124
147Rectal prolapse (HP:0002035)1.66063840
148Narrow nasal bridge (HP:0000446)1.63082677
149Nephronophthisis (HP:0000090)1.62587044
150Aplasia/Hypoplasia of the fibula (HP:0006492)1.61599768
151Megalencephaly (HP:0001355)1.60865257
152Persistence of primary teeth (HP:0006335)1.60721020
153Vaginal atresia (HP:0000148)1.59782924
154Broad thumb (HP:0011304)1.58287538
155Renal hypoplasia (HP:0000089)1.56644428
156Genital tract atresia (HP:0001827)1.56615357
157Bronchomalacia (HP:0002780)1.55932587
158Broad phalanges of the hand (HP:0009768)1.55505644
159Broad finger (HP:0001500)1.54297899
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.54242122
161Hypoplastic labia majora (HP:0000059)1.53261297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.10231213
2LATS14.07109777
3DDR23.79944017
4PDGFRA3.27443544
5TRIB32.94623539
6TNIK2.68705815
7EPHB22.62663249
8SIK12.56618870
9LATS22.48822365
10PAK22.33372747
11ERN12.15121752
12WNK32.13495787
13BMX2.10493419
14PKN22.09181712
15EPHA22.04522643
16TGFBR21.99116595
17STK38L1.97191951
18TRPM71.88616447
19RIPK11.77888822
20PTK21.77869084
21PTK61.75569337
22STK31.74559136
23PNCK1.73633670
24MAP4K21.71154843
25EEF2K1.69646980
26EPHA31.67437873
27MARK11.59427636
28CDK121.56436404
29NLK1.53681774
30BCR1.52958509
31FER1.51510625
32TIE11.47985871
33DMPK1.46576979
34PAK41.45731888
35EPHB11.44182869
36PAK31.43616110
37STK101.38657492
38AKT31.33243511
39PINK11.32126981
40MAPK151.30915233
41CASK1.30840217
42MTOR1.28653165
43MYLK1.27867707
44LRRK21.26658714
45FGFR11.24964795
46MET1.24493325
47PIK3CA1.21548543
48NTRK21.19812969
49PDGFRB1.19430326
50ADRBK21.18143767
51ROCK11.18106052
52PTK2B1.17071139
53NEK91.14689556
54TGFBR11.13189302
55MKNK11.12910831
56MAP3K101.07396569
57SGK21.07009921
58CAMK1D1.03752544
59MAPKAPK31.03115005
60MAP3K41.02855610
61NTRK11.02694308
62OXSR11.00849859
63ERBB41.00548956
64FRK0.99817808
65EPHA40.96992553
66BMPR1B0.96224928
67FGFR20.92472978
68ICK0.90950575
69MAPK130.89080507
70SGK2230.88969133
71SGK4940.88969133
72GRK10.87707050
73MOS0.83720608
74ROCK20.81240036
75PRKD20.80604898
76FGFR40.79684157
77RPS6KA40.76829665
78INSRR0.75840315
79DYRK20.73393824
80CAMK1G0.72457838
81CHUK0.69977910
82CDK60.69666745
83WNK40.68903370
84FGFR30.66851218
85TYRO30.66846528
86OBSCN0.65018370
87INSR0.62389064
88PKN10.61721856
89PRKD10.60740761
90RET0.60350078
91IRAK10.57185761
92CAMK10.57167323
93TESK10.55628630
94CDK80.53983374
95WEE10.53541235
96ILK0.53457587
97MKNK20.53372203
98MAPKAPK50.53062909
99PLK30.52219926
100CDC42BPA0.51951084
101CSNK1G10.51026649
102MAP3K80.50656835
103DYRK1B0.49681765
104PRKG20.49181317
105WNK10.49152826
106PIM20.48277051
107MAP3K30.46353750
108ACVR1B0.45286353
109JAK10.45217822
110SRC0.44014294
111CDK30.43164071
112PRKG10.43161125
113FLT30.42887517
114PRKCH0.42765993
115CSNK1G20.41685670
116BRSK20.41664011
117STK240.41499457
118CAMK2A0.41450925
119PRKCE0.41305138
120PRKCG0.41057326
121MAP2K10.40961205
122KDR0.40739175
123MAP3K70.40717723
124PRKAA20.40085440
125MST1R0.39528945
126PRKAA10.38485748
127NUAK10.37477748
128PRKD30.37290127
129VRK10.37255942
130ABL20.37198497
131RPS6KA20.36690662
132PRKACB0.36006685
133MAPK10.35862264
134RPS6KB20.35779841
135SGK30.35270903
136NEK20.34888471
137DYRK1A0.34799790
138LMTK20.34222051
139MELK0.33553676
140ERBB20.33289594
141IGF1R0.33088210
142LIMK10.32749855
143GSK3A0.32533658
144ADRBK10.31508917
145MARK20.30744418
146STK380.30445540
147MAPKAPK20.30440230
148ABL10.29341341
149PLK20.29284859
150STK390.28759542
151JAK30.27507349
152PAK10.26891065
153PIK3CG0.26554460

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.43230664
2Focal adhesion_Homo sapiens_hsa045103.12809077
3Adherens junction_Homo sapiens_hsa045202.54972977
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.44431680
5Amoebiasis_Homo sapiens_hsa051462.41247179
6Small cell lung cancer_Homo sapiens_hsa052222.38068894
7Proteoglycans in cancer_Homo sapiens_hsa052052.34157238
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.32623349
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.27951898
10Dilated cardiomyopathy_Homo sapiens_hsa054142.14478355
11Protein digestion and absorption_Homo sapiens_hsa049742.05920949
12Hippo signaling pathway_Homo sapiens_hsa043902.04980472
13Bladder cancer_Homo sapiens_hsa052191.94239554
14TGF-beta signaling pathway_Homo sapiens_hsa043501.94028293
15Malaria_Homo sapiens_hsa051441.90170652
16Basal cell carcinoma_Homo sapiens_hsa052171.89237384
17MicroRNAs in cancer_Homo sapiens_hsa052061.83654168
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79639034
19PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60475470
20Regulation of actin cytoskeleton_Homo sapiens_hsa048101.57535551
21Melanoma_Homo sapiens_hsa052181.55534876
22Hedgehog signaling pathway_Homo sapiens_hsa043401.50045167
23Viral myocarditis_Homo sapiens_hsa054161.48837930
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.48127339
25Chronic myeloid leukemia_Homo sapiens_hsa052201.46134946
26Nitrogen metabolism_Homo sapiens_hsa009101.45142718
27Propanoate metabolism_Homo sapiens_hsa006401.41016639
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.40395857
29Tight junction_Homo sapiens_hsa045301.36943798
30Circadian rhythm_Homo sapiens_hsa047101.34942507
31Circadian entrainment_Homo sapiens_hsa047131.34191019
32Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25989652
33Axon guidance_Homo sapiens_hsa043601.25453060
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22326707
35Pathways in cancer_Homo sapiens_hsa052001.21041248
36Prostate cancer_Homo sapiens_hsa052151.20771125
37p53 signaling pathway_Homo sapiens_hsa041151.19542855
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.18894458
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18535651
40Renin secretion_Homo sapiens_hsa049241.17595224
41Pancreatic cancer_Homo sapiens_hsa052121.17135001
42Glutamatergic synapse_Homo sapiens_hsa047241.11705338
43Toxoplasmosis_Homo sapiens_hsa051451.09059965
44Rap1 signaling pathway_Homo sapiens_hsa040151.08784523
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08080422
46TNF signaling pathway_Homo sapiens_hsa046681.03335164
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02378417
48Calcium signaling pathway_Homo sapiens_hsa040201.01089811
49Insulin secretion_Homo sapiens_hsa049110.99377893
50Morphine addiction_Homo sapiens_hsa050320.96897660
51Complement and coagulation cascades_Homo sapiens_hsa046100.95234597
52Phototransduction_Homo sapiens_hsa047440.94198206
53Cocaine addiction_Homo sapiens_hsa050300.93091569
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92615687
55Lysine degradation_Homo sapiens_hsa003100.91785582
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91344635
57Shigellosis_Homo sapiens_hsa051310.90974660
58cAMP signaling pathway_Homo sapiens_hsa040240.90795102
59Wnt signaling pathway_Homo sapiens_hsa043100.89801281
60GABAergic synapse_Homo sapiens_hsa047270.88635574
61Selenocompound metabolism_Homo sapiens_hsa004500.87541314
62Ovarian steroidogenesis_Homo sapiens_hsa049130.86950832
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.86916907
64Platelet activation_Homo sapiens_hsa046110.86187527
65ABC transporters_Homo sapiens_hsa020100.85713222
66Serotonergic synapse_Homo sapiens_hsa047260.85531281
67HTLV-I infection_Homo sapiens_hsa051660.83900057
68Notch signaling pathway_Homo sapiens_hsa043300.83598178
69Salmonella infection_Homo sapiens_hsa051320.81534132
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81479180
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80442729
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78740730
73Linoleic acid metabolism_Homo sapiens_hsa005910.78338175
74Long-term depression_Homo sapiens_hsa047300.78141158
75Glioma_Homo sapiens_hsa052140.77033417
76Cardiac muscle contraction_Homo sapiens_hsa042600.76802333
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.76571328
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75229253
79Oxytocin signaling pathway_Homo sapiens_hsa049210.73964872
80Renin-angiotensin system_Homo sapiens_hsa046140.72730389
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71618890
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70265958
83Thyroid hormone synthesis_Homo sapiens_hsa049180.69981415
84Cholinergic synapse_Homo sapiens_hsa047250.68017784
85Dopaminergic synapse_Homo sapiens_hsa047280.67921540
86Glycerolipid metabolism_Homo sapiens_hsa005610.67001069
87Gastric acid secretion_Homo sapiens_hsa049710.66946263
88FoxO signaling pathway_Homo sapiens_hsa040680.65381014
89Salivary secretion_Homo sapiens_hsa049700.65220649
90Taste transduction_Homo sapiens_hsa047420.63439211
91Insulin resistance_Homo sapiens_hsa049310.62878432
92Renal cell carcinoma_Homo sapiens_hsa052110.62794475
93Nicotine addiction_Homo sapiens_hsa050330.62264556
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60697256
95Dorso-ventral axis formation_Homo sapiens_hsa043200.60603533
96Butanoate metabolism_Homo sapiens_hsa006500.60395253
97Colorectal cancer_Homo sapiens_hsa052100.60156560
98PPAR signaling pathway_Homo sapiens_hsa033200.59064593
99Phagosome_Homo sapiens_hsa041450.58742461
100Endometrial cancer_Homo sapiens_hsa052130.58408096
101Fatty acid biosynthesis_Homo sapiens_hsa000610.58350256
102Choline metabolism in cancer_Homo sapiens_hsa052310.57883991
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57203084
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57122349
105Melanogenesis_Homo sapiens_hsa049160.57112782
106Ras signaling pathway_Homo sapiens_hsa040140.56562231
107Ether lipid metabolism_Homo sapiens_hsa005650.56543666
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.56246613
109HIF-1 signaling pathway_Homo sapiens_hsa040660.55799782
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.55740398
111Amphetamine addiction_Homo sapiens_hsa050310.55613808
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54692014
113Hepatitis B_Homo sapiens_hsa051610.54681789
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54103478
115Viral carcinogenesis_Homo sapiens_hsa052030.53130447
116Caffeine metabolism_Homo sapiens_hsa002320.52783064
117Leishmaniasis_Homo sapiens_hsa051400.52287068
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.52283184
119mTOR signaling pathway_Homo sapiens_hsa041500.51649652
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51155546
121Apoptosis_Homo sapiens_hsa042100.49443685
122Histidine metabolism_Homo sapiens_hsa003400.49282204
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48957040
124beta-Alanine metabolism_Homo sapiens_hsa004100.48214313
125Arginine and proline metabolism_Homo sapiens_hsa003300.47148631
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45356578
127Olfactory transduction_Homo sapiens_hsa047400.45053099
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44929264
129Pancreatic secretion_Homo sapiens_hsa049720.44663791
130MAPK signaling pathway_Homo sapiens_hsa040100.43704439
131Arachidonic acid metabolism_Homo sapiens_hsa005900.43701745
132Prion diseases_Homo sapiens_hsa050200.43544680
133Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43278788
134Protein export_Homo sapiens_hsa030600.42298339
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.41524590
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41104373
137AMPK signaling pathway_Homo sapiens_hsa041520.40055509
138Estrogen signaling pathway_Homo sapiens_hsa049150.39964076
139Glycosaminoglycan degradation_Homo sapiens_hsa005310.39316860
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38502273
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37847560
142Gap junction_Homo sapiens_hsa045400.37471965
143Osteoclast differentiation_Homo sapiens_hsa043800.37387524
144Endocytosis_Homo sapiens_hsa041440.37305280
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.37037288
146Bile secretion_Homo sapiens_hsa049760.36841987
147Acute myeloid leukemia_Homo sapiens_hsa052210.35905064
148cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34633452
149Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.33360712
150ErbB signaling pathway_Homo sapiens_hsa040120.32690872
151Tryptophan metabolism_Homo sapiens_hsa003800.32287700
152Tuberculosis_Homo sapiens_hsa051520.30312218
153Hematopoietic cell lineage_Homo sapiens_hsa046400.30064312

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