STOX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene may function as a DNA binding protein. Mutations in this gene are associated with pre-eclampsia/eclampsia 4 (PEE4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.51733609
2multicellular organism reproduction (GO:0032504)9.40448246
3negative regulation of fibroblast apoptotic process (GO:2000270)8.15717926
4microtubule depolymerization (GO:0007019)7.72228077
5acrosome reaction (GO:0007340)7.70462764
6sperm-egg recognition (GO:0035036)7.58075409
7reproduction (GO:0000003)7.55531404
8negative regulation of translation involved in gene silencing by miRNA (GO:0035278)7.53443447
9negative regulation of translation, ncRNA-mediated (GO:0040033)7.53443447
10regulation of translation, ncRNA-mediated (GO:0045974)7.53443447
11acrosome assembly (GO:0001675)7.51588886
12male meiosis (GO:0007140)7.16319223
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.13740138
14DNA methylation involved in gamete generation (GO:0043046)7.09141540
15pre-miRNA processing (GO:0031054)7.08771705
16cell-cell recognition (GO:0009988)6.79278027
17epithelial cilium movement (GO:0003351)6.65610387
18meiotic cell cycle (GO:0051321)6.03726033
19spermatid development (GO:0007286)5.97761672
20binding of sperm to zona pellucida (GO:0007339)5.83801990
21meiotic nuclear division (GO:0007126)5.65479731
22regulation of fibroblast apoptotic process (GO:2000269)5.60818640
23cilium movement (GO:0003341)5.57047628
24proline biosynthetic process (GO:0006561)5.49033123
25positive regulation of transcription from RNA polymerase III promoter (GO:0045945)5.48238228
26sperm motility (GO:0030317)5.35651820
27synaptonemal complex organization (GO:0070193)5.28535208
28synaptonemal complex assembly (GO:0007130)5.26146329
29single fertilization (GO:0007338)5.18284969
30male genitalia development (GO:0030539)5.11290130
31negative regulation of osteoblast proliferation (GO:0033689)5.07388232
32reproductive system development (GO:0061458)4.94726623
33axoneme assembly (GO:0035082)4.91396593
34neurotransmitter-gated ion channel clustering (GO:0072578)4.84752630
35regulation of meiosis I (GO:0060631)4.82725240
36gene silencing by RNA (GO:0031047)4.75516350
37chromosome organization involved in meiosis (GO:0070192)4.73980282
38calcium ion-dependent exocytosis (GO:0017156)4.68225565
39positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.66836754
40regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.66836754
41somatic diversification of immune receptors via somatic mutation (GO:0002566)4.44928634
42somatic hypermutation of immunoglobulin genes (GO:0016446)4.44928634
43regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.40251025
44positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.40251025
45lipoprotein transport (GO:0042953)4.36625363
46male meiosis I (GO:0007141)4.30073099
47retinal rod cell development (GO:0046548)4.27610669
48protein K11-linked deubiquitination (GO:0035871)4.24413101
49S-adenosylmethionine metabolic process (GO:0046500)4.22023754
50fertilization (GO:0009566)4.18475139
51macroautophagy (GO:0016236)4.14649514
52lipid particle organization (GO:0034389)4.12352491
53centriole replication (GO:0007099)4.09597589
54proline metabolic process (GO:0006560)4.06318733
55centriole assembly (GO:0098534)4.05477371
56microtubule polymerization or depolymerization (GO:0031109)3.97529192
57cilium morphogenesis (GO:0060271)3.96235761
58negative regulation of cytokine biosynthetic process (GO:0042036)3.94627647
59mRNA cleavage (GO:0006379)3.87168633
60regulation of cilium movement (GO:0003352)3.86664180
61spermatid nucleus differentiation (GO:0007289)3.79214779
62left/right pattern formation (GO:0060972)3.73926893
63regulation of action potential (GO:0098900)3.67333166
64sister chromatid cohesion (GO:0007062)3.66631767
65carnitine transmembrane transport (GO:1902603)3.63853027
66protein localization to cilium (GO:0061512)3.62818774
67spermatogenesis (GO:0007283)3.60821111
68male gamete generation (GO:0048232)3.59869834
69intraciliary transport (GO:0042073)3.57300489
70nonmotile primary cilium assembly (GO:0035058)3.56508685
71germ cell development (GO:0007281)3.55379844
72cellular process involved in reproduction in multicellular organism (GO:0022412)3.53274616
73L-serine metabolic process (GO:0006563)3.49118447
74amino-acid betaine transport (GO:0015838)3.49071148
75carnitine transport (GO:0015879)3.49071148
76amino acid salvage (GO:0043102)3.46111417
77L-methionine salvage (GO:0071267)3.46111417
78L-methionine biosynthetic process (GO:0071265)3.46111417
79central nervous system myelination (GO:0022010)3.42005018
80axon ensheathment in central nervous system (GO:0032291)3.42005018
81tongue development (GO:0043586)3.41798326
82cerebral cortex radially oriented cell migration (GO:0021799)3.41137998
83meiosis I (GO:0007127)3.36931786
84gamete generation (GO:0007276)3.36749976
85positive regulation of mRNA catabolic process (GO:0061014)3.36184397
86polyol catabolic process (GO:0046174)3.31574363
87neural tube formation (GO:0001841)3.29570371
88presynaptic membrane assembly (GO:0097105)3.29258126
89microtubule bundle formation (GO:0001578)3.28222906
90regulation of chromatin binding (GO:0035561)3.27915827
91cilium assembly (GO:0042384)3.27868935
92protein prenylation (GO:0018342)3.26737412
93prenylation (GO:0097354)3.26737412
94snRNA processing (GO:0016180)3.22351872
95left/right axis specification (GO:0070986)3.21385192
96cilium organization (GO:0044782)3.21072914
97cell recognition (GO:0008037)3.20830349
98ventricular system development (GO:0021591)3.20448814
99negative regulation of translational initiation (GO:0045947)3.15581345
100regulation of acrosome reaction (GO:0060046)3.10445185
101regulation of mRNA catabolic process (GO:0061013)3.10252243
102vitamin transmembrane transport (GO:0035461)3.09680390
103positive regulation of Rho protein signal transduction (GO:0035025)3.09647158
104preassembly of GPI anchor in ER membrane (GO:0016254)3.09470616
105peptidyl-threonine dephosphorylation (GO:0035970)3.08376624
106synapsis (GO:0007129)3.05282447
107microtubule-based movement (GO:0007018)2.99956489
108negative regulation of astrocyte differentiation (GO:0048712)2.97470483
109replication fork processing (GO:0031297)2.94490341
110protein-cofactor linkage (GO:0018065)2.94305991
111snRNA metabolic process (GO:0016073)2.94128277
112positive regulation of mRNA 3-end processing (GO:0031442)2.90861467
113sperm capacitation (GO:0048240)2.90143381
114phosphorelay signal transduction system (GO:0000160)2.88287356
115positive regulation of meiosis (GO:0045836)2.88115484
116DNA methylation (GO:0006306)2.84663280
117DNA alkylation (GO:0006305)2.84663280
118primary alcohol catabolic process (GO:0034310)2.83944869
119oogenesis (GO:0048477)2.80695086
120regulation of transcription from RNA polymerase III promoter (GO:0006359)2.80660355
121protein neddylation (GO:0045116)2.79868466
122phosphatidylglycerol biosynthetic process (GO:0006655)2.78639233
123cellular component assembly involved in morphogenesis (GO:0010927)2.78230351
124organic cation transport (GO:0015695)2.77490576
125meiotic cell cycle process (GO:1903046)2.77399688
126postsynaptic membrane organization (GO:0001941)2.77152769
127regulation of DNA endoreduplication (GO:0032875)2.74643278
128positive regulation of dendritic spine morphogenesis (GO:0061003)2.73434685
129glutamine family amino acid biosynthetic process (GO:0009084)2.71675385
130cytoplasmic microtubule organization (GO:0031122)2.71163397
131presynaptic membrane organization (GO:0097090)2.68726830
132positive regulation of meiotic cell cycle (GO:0051446)2.68262135
133apical protein localization (GO:0045176)2.61809679
134anterograde axon cargo transport (GO:0008089)2.58532721
135negative regulation of inclusion body assembly (GO:0090084)2.56306881
136smoothened signaling pathway (GO:0007224)2.56153232
137positive regulation of smoothened signaling pathway (GO:0045880)2.53755894
138retinal cone cell development (GO:0046549)2.52865987
139photoreceptor cell maintenance (GO:0045494)2.52229546
140regulation of smoothened signaling pathway (GO:0008589)2.51297831
141L-amino acid import (GO:0043092)2.51278818
142appendage development (GO:0048736)2.50947401
143limb development (GO:0060173)2.50947401
144regulation of microtubule-based movement (GO:0060632)2.49407702
145maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.47257021
146diterpenoid biosynthetic process (GO:0016102)2.44717491
147regulation of lipoprotein metabolic process (GO:0050746)2.43753211
148one-carbon compound transport (GO:0019755)2.41690566
149notochord development (GO:0030903)2.41400369
150pericardium development (GO:0060039)2.40328030
151amino acid import (GO:0043090)2.39569470
152mitotic sister chromatid cohesion (GO:0007064)2.38343854
153cochlea development (GO:0090102)2.34003386
154mechanosensory behavior (GO:0007638)2.33081955
155cell projection assembly (GO:0030031)2.33010111
156lateral ventricle development (GO:0021670)2.32166920
157lung epithelium development (GO:0060428)2.31703703
158kinetochore organization (GO:0051383)2.31442654
159DNA double-strand break processing (GO:0000729)2.29907787
160mismatch repair (GO:0006298)2.29773880
161ephrin receptor signaling pathway (GO:0048013)2.29604595
162regulation of sister chromatid cohesion (GO:0007063)2.29212737
163negative regulation of keratinocyte proliferation (GO:0010839)2.26552555
164histone H2A acetylation (GO:0043968)2.25365473
165eye photoreceptor cell differentiation (GO:0001754)2.21993647
166photoreceptor cell differentiation (GO:0046530)2.21993647
167DNA strand renaturation (GO:0000733)2.20420121
168cerebellar granule cell differentiation (GO:0021707)2.17260110
169cell wall macromolecule metabolic process (GO:0044036)13.2357398
170cell wall macromolecule catabolic process (GO:0016998)13.2357398
171fusion of sperm to egg plasma membrane (GO:0007342)12.5394605
172cilium or flagellum-dependent cell motility (GO:0001539)11.6274593
173piRNA metabolic process (GO:0034587)11.3871795
174motile cilium assembly (GO:0044458)10.4675314
175axonemal dynein complex assembly (GO:0070286)10.1615322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse9.90249881
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.76920511
3EZH2_22144423_ChIP-Seq_EOC_Human4.23449891
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.11605359
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.61517017
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.20989698
7NOTCH1_21737748_ChIP-Seq_TLL_Human2.91597456
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.77617554
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.70273903
10KAP1_22055183_ChIP-Seq_ESCs_Mouse2.68886319
11TAF15_26573619_Chip-Seq_HEK293_Human2.56496460
12ELK4_26923725_Chip-Seq_MESODERM_Mouse2.33362731
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.27445764
14E2F7_22180533_ChIP-Seq_HELA_Human2.26968180
15AR_21572438_ChIP-Seq_LNCaP_Human2.17297223
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06861423
17PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95760825
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.91517143
19* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.91259848
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.88551138
21FUS_26573619_Chip-Seq_HEK293_Human1.87850202
22EWS_26573619_Chip-Seq_HEK293_Human1.87752374
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86772572
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81904261
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79304041
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.76411005
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74024913
28SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73761133
29GATA3_21867929_ChIP-Seq_CD8_Mouse1.73121065
30VDR_22108803_ChIP-Seq_LS180_Human1.72132114
31P300_19829295_ChIP-Seq_ESCs_Human1.70769691
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.68720534
33CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66727130
34ZNF274_21170338_ChIP-Seq_K562_Hela1.66140569
35CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.65712254
36RUNX1_26923725_Chip-Seq_HPCs_Mouse1.64482590
37NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.63421890
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57897688
39TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57378848
40* CRX_20693478_ChIP-Seq_RETINA_Mouse1.56166793
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.55914287
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55385137
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.55385137
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.55092908
45GBX2_23144817_ChIP-Seq_PC3_Human1.54763511
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53816350
47* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52386950
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51078429
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.50180334
50STAT3_18555785_Chip-Seq_ESCs_Mouse1.50179478
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48213366
52SUZ12_18555785_Chip-Seq_ESCs_Mouse1.46595517
53OCT4_18555785_Chip-Seq_ESCs_Mouse1.46498105
54TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45516918
55KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.45427095
56TAL1_26923725_Chip-Seq_HPCs_Mouse1.45327462
57P300_18555785_Chip-Seq_ESCs_Mouse1.43201098
58AR_21909140_ChIP-Seq_LNCAP_Human1.43196607
59RUNX1_27457419_Chip-Seq_LIVER_Mouse1.42206353
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.41197590
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40900569
62FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40697979
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39664296
64STAT3_23295773_ChIP-Seq_U87_Human1.38495304
65ESRRB_18555785_Chip-Seq_ESCs_Mouse1.37872163
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37718839
67KLF4_18555785_Chip-Seq_ESCs_Mouse1.37542896
68IGF1R_20145208_ChIP-Seq_DFB_Human1.37446733
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37351536
70* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36866651
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.36800574
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36099928
73SOX2_18555785_Chip-Seq_ESCs_Mouse1.36057822
74* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.35541271
75* STAT1_17558387_ChIP-Seq_HELA_Human1.35172755
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.35160336
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34980813
78E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34412658
79CTCF_18555785_Chip-Seq_ESCs_Mouse1.31768455
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.31397687
81SMAD1_18555785_Chip-Seq_ESCs_Mouse1.31093044
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30617942
83ER_23166858_ChIP-Seq_MCF-7_Human1.30301481
84FOXM1_23109430_ChIP-Seq_U2OS_Human1.29905201
85TCF4_22108803_ChIP-Seq_LS180_Human1.29560700
86GF1B_26923725_Chip-Seq_HPCs_Mouse1.29149498
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28559733
88* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.28379976
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27989780
90P53_22387025_ChIP-Seq_ESCs_Mouse1.27702692
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27598999
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.27455923
93P53_22127205_ChIP-Seq_FIBROBLAST_Human1.26269856
94KDM2B_26808549_Chip-Seq_REH_Human1.25860790
95AR_25329375_ChIP-Seq_VCAP_Human1.24924964
96RUNX2_22187159_ChIP-Seq_PCA_Human1.24832417
97TCF4_23295773_ChIP-Seq_U87_Human1.24773493
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24730916
99DROSHA_22980978_ChIP-Seq_HELA_Human1.24525041
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.23981227
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.21212146
102* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.21028577
103SMAD3_21741376_ChIP-Seq_EPCs_Human1.20696194
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20339883
105* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19710778
106ZFX_18555785_Chip-Seq_ESCs_Mouse1.19513517
107PU1_27457419_Chip-Seq_LIVER_Mouse1.18540744
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18455823
109CBP_20019798_ChIP-Seq_JUKART_Human1.18455823
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18135388
111LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18134509
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.17179616
113WDR5_24793694_ChIP-Seq_LNCAP_Human1.16250415
114FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15479815
115GATA3_21867929_ChIP-Seq_TH1_Mouse1.13245734
116SCL_19346495_ChIP-Seq_HPC-7_Human1.12764289
117TBL1_22424771_ChIP-Seq_293T_Human1.12745978
118EZH2_27304074_Chip-Seq_ESCs_Mouse1.12125539
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.11326970
120E2F1_17053090_ChIP-ChIP_MCF-7_Human1.11221835
121ETS1_22383799_ChIP-Seq_G1ME_Mouse1.07946384
122SOX9_26525672_Chip-Seq_HEART_Mouse1.07015391
123* CBP_21632823_ChIP-Seq_H3396_Human1.06890877
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06497391
125POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.05759951
126REST_21632747_ChIP-Seq_MESCs_Mouse1.03765889
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02998527
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02814987
129* FLI1_21867929_ChIP-Seq_TH2_Mouse1.02269758
130PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00486764
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00435500
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00307495
133FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.00300529
134* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00053540
135RNF2_27304074_Chip-Seq_NSC_Mouse0.99965627
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99429420
137LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99016408
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98722163
139SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97198294
140EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96756458
141AHR_22903824_ChIP-Seq_MCF-7_Human0.96355800
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95667333
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.95537939
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.94533348
145* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.94421650
146RXRA_24833708_ChIP-Seq_LIVER_Mouse0.94311074
147SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94146510
148EZH2_18974828_ChIP-Seq_MESCs_Mouse0.93732626
149RNF2_18974828_ChIP-Seq_MESCs_Mouse0.93732626
150NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93439318
151* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.93336167
152POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91711503
153BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91387848
154* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90981445
155PRDM14_20953172_ChIP-Seq_ESCs_Human0.90705324
156BCAT_22108803_ChIP-Seq_LS180_Human0.90330915
157* AR_19668381_ChIP-Seq_PC3_Human0.89123971
158RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88998544
159NFYA_21822215_ChIP-Seq_K562_Human0.88893794
160GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88817990
161CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88231861
162SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87655052
163ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87521262
164FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87138228
165GF1_26923725_Chip-Seq_HPCs_Mouse0.83421781
166RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82265802
167ESET_19884257_ChIP-Seq_ESCs_Mouse0.82238972
168STAT3_18555785_ChIP-Seq_MESCs_Mouse0.81409504
169MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.79564862
170CDX2_22108803_ChIP-Seq_LS180_Human0.78668986
171EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.77904588
172SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.77605029
173* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77175070
174FLI1_21867929_ChIP-Seq_CD8_Mouse0.76408818
175* RARA_24833708_ChIP-Seq_LIVER_Mouse0.76213401
176AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75676538
177EGR1_19374776_ChIP-ChIP_THP-1_Human0.74682622
178MYCN_18555785_ChIP-Seq_MESCs_Mouse0.73886446
179CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73774790
180STAT6_21828071_ChIP-Seq_BEAS2B_Human0.73513763
181NFYB_21822215_ChIP-Seq_K562_Human0.72995518
182* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.72330070
183SMAD4_21799915_ChIP-Seq_A2780_Human0.71193027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color6.66384442
2MP0005410_abnormal_fertilization6.66277671
3MP0000566_synostosis4.91388609
4MP0000015_abnormal_ear_pigmentation4.29605975
5MP0005174_abnormal_tail_pigmentation4.18749093
6MP0002653_abnormal_ependyma_morphology4.13414695
7MP0001929_abnormal_gametogenesis3.99834946
8MP0008877_abnormal_DNA_methylation3.61111800
9MP0003698_abnormal_male_reproductive3.59966667
10MP0002102_abnormal_ear_morphology3.33062603
11MP0001346_abnormal_lacrimal_gland2.96390050
12MP0009046_muscle_twitch2.89997956
13MP0002210_abnormal_sex_determination2.87550526
14MP0006292_abnormal_olfactory_placode2.78874809
15MP0001145_abnormal_male_reproductive2.66143695
16MP0003890_abnormal_embryonic-extraembry2.61718964
17MP0000653_abnormal_sex_gland2.37372368
18MP0003880_abnormal_central_pattern2.32602982
19MP0010094_abnormal_chromosome_stability2.31766366
20MP0008058_abnormal_DNA_repair2.31500651
21MP0004885_abnormal_endolymph2.17376723
22MP0010030_abnormal_orbit_morphology2.07905510
23MP0008789_abnormal_olfactory_epithelium2.05945961
24MP0003136_yellow_coat_color1.93858029
25MP0004808_abnormal_hematopoietic_stem1.93627357
26MP0000537_abnormal_urethra_morphology1.91498690
27MP0001188_hyperpigmentation1.89830653
28MP0001984_abnormal_olfaction1.86261546
29MP0004133_heterotaxia1.83644598
30MP0002161_abnormal_fertility/fecundity1.83583999
31MP0002234_abnormal_pharynx_morphology1.81521831
32MP0001986_abnormal_taste_sensitivity1.80237148
33MP0002095_abnormal_skin_pigmentation1.78413595
34MP0001485_abnormal_pinna_reflex1.77008179
35MP0004043_abnormal_pH_regulation1.76615861
36MP0000778_abnormal_nervous_system1.76256593
37MP0004130_abnormal_muscle_cell1.75939800
38MP0002160_abnormal_reproductive_system1.71763463
39MP0004859_abnormal_synaptic_plasticity1.69734531
40MP0001486_abnormal_startle_reflex1.64681084
41MP0005394_taste/olfaction_phenotype1.63059981
42MP0005499_abnormal_olfactory_system1.63059981
43MP0004742_abnormal_vestibular_system1.55515769
44MP0004957_abnormal_blastocyst_morpholog1.54026112
45MP0008875_abnormal_xenobiotic_pharmacok1.47600057
46MP0003938_abnormal_ear_development1.47520342
47MP0005646_abnormal_pituitary_gland1.46167070
48MP0003937_abnormal_limbs/digits/tail_de1.42138457
49MP0003635_abnormal_synaptic_transmissio1.41173567
50MP0002734_abnormal_mechanical_nocicepti1.38717437
51MP0000747_muscle_weakness1.38431974
52MP0000049_abnormal_middle_ear1.36597945
53MP0005367_renal/urinary_system_phenotyp1.34755413
54MP0000516_abnormal_urinary_system1.34755413
55MP0010678_abnormal_skin_adnexa1.33020959
56MP0003315_abnormal_perineum_morphology1.28813768
57MP0003861_abnormal_nervous_system1.25520767
58MP0005551_abnormal_eye_electrophysiolog1.25357892
59MP0003718_maternal_effect1.24765313
60MP0002736_abnormal_nociception_after1.24075090
61MP0001963_abnormal_hearing_physiology1.23720017
62MP0005248_abnormal_Harderian_gland1.21840550
63MP0009745_abnormal_behavioral_response1.21344459
64MP0009053_abnormal_anal_canal1.20145349
65MP0003111_abnormal_nucleus_morphology1.18838948
66MP0003693_abnormal_embryo_hatching1.18816229
67MP0002249_abnormal_larynx_morphology1.18568540
68MP0005535_abnormal_body_temperature1.17834799
69MP0002064_seizures1.17763130
70MP0000631_abnormal_neuroendocrine_gland1.16338836
71MP0004233_abnormal_muscle_weight1.16210607
72MP0002272_abnormal_nervous_system1.15418860
73MP0005379_endocrine/exocrine_gland_phen1.15259823
74MP0002152_abnormal_brain_morphology1.15215681
75MP0008995_early_reproductive_senescence1.14325891
76MP0002269_muscular_atrophy1.13425864
77MP0005645_abnormal_hypothalamus_physiol1.12393818
78MP0003119_abnormal_digestive_system1.11517322
79MP0001968_abnormal_touch/_nociception1.10361819
80MP0002557_abnormal_social/conspecific_i1.09807720
81MP0002063_abnormal_learning/memory/cond1.09376603
82MP0001944_abnormal_pancreas_morphology1.07546241
83MP0008961_abnormal_basal_metabolism1.06533306
84MP0003755_abnormal_palate_morphology1.06376930
85MP0002735_abnormal_chemical_nociception1.04710180
86MP0003935_abnormal_craniofacial_develop1.02113286
87MP0002277_abnormal_respiratory_mucosa1.01919924
88MP0002282_abnormal_trachea_morphology1.01531927
89MP0002177_abnormal_outer_ear1.01159507
90MP0002693_abnormal_pancreas_physiology1.00310955
91MP0002971_abnormal_brown_adipose1.00002685
92MP0008932_abnormal_embryonic_tissue0.99381607
93MP0002084_abnormal_developmental_patter0.98588534
94MP0002572_abnormal_emotion/affect_behav0.98465874
95MP0001502_abnormal_circadian_rhythm0.97860879
96MP0000762_abnormal_tongue_morphology0.94979071
97MP0003077_abnormal_cell_cycle0.94962324
98MP0002138_abnormal_hepatobiliary_system0.94638128
99MP0001119_abnormal_female_reproductive0.94538732
100MP0002116_abnormal_craniofacial_bone0.94294007
101MP0002009_preneoplasia0.93836317
102MP0002882_abnormal_neuron_morphology0.93148527
103MP0000358_abnormal_cell_content/0.92821624
104MP0001186_pigmentation_phenotype0.92280237
105MP0001177_atelectasis0.91698794
106MP0005670_abnormal_white_adipose0.91572781
107MP0008057_abnormal_DNA_replication0.91411013
108MP0001730_embryonic_growth_arrest0.91353373
109MP0002928_abnormal_bile_duct0.90659736
110MP0000678_abnormal_parathyroid_gland0.88266013
111MP0003045_fibrosis0.88186688
112MP0004947_skin_inflammation0.87421088
113MP0002067_abnormal_sensory_capabilities0.87293900
114MP0005187_abnormal_penis_morphology0.86585322
115MP0005423_abnormal_somatic_nervous0.86405015
116MP0010368_abnormal_lymphatic_system0.85150921
117MP0005389_reproductive_system_phenotype0.85094243
118MP0002229_neurodegeneration0.84622004
119MP0003959_abnormal_lean_body0.84188296
120MP0005623_abnormal_meninges_morphology0.83949184
121MP0003942_abnormal_urinary_system0.83797047
122MP0002075_abnormal_coat/hair_pigmentati0.83284864
123MP0005391_vision/eye_phenotype0.80721937
124MP0005253_abnormal_eye_physiology0.80502993
125MP0005377_hearing/vestibular/ear_phenot0.79608767
126MP0009780_abnormal_chondrocyte_physiolo0.73087229
127MP0005310_abnormal_salivary_gland0.70525277
128MP0002163_abnormal_gland_morphology0.70146988
129MP0002078_abnormal_glucose_homeostasis0.69406830
130MP0002877_abnormal_melanocyte_morpholog0.69177700
131MP0001293_anophthalmia0.68865359
132MP0003195_calcinosis0.68504975
133MP0002233_abnormal_nose_morphology0.67274218
134MP0003879_abnormal_hair_cell0.64633815
135MP0000681_abnormal_thyroid_gland0.63217964
136MP0000703_abnormal_thymus_morphology0.61276608
137MP0002876_abnormal_thyroid_physiology0.61045763
138MP0004811_abnormal_neuron_physiology0.59177164
139MP0010307_abnormal_tumor_latency0.58773263
140MP0009703_decreased_birth_body0.58667217
141MP0010386_abnormal_urinary_bladder0.57937529
142MP0005167_abnormal_blood-brain_barrier0.57131138
143MP0003172_abnormal_lysosome_physiology0.56423436
144MP0001529_abnormal_vocalization0.56232658
145MP0000428_abnormal_craniofacial_morphol0.53843865
146MP0001299_abnormal_eye_distance/0.53676765
147MP0003953_abnormal_hormone_level0.52942323
148MP0009115_abnormal_fat_cell0.52854913
149MP0000313_abnormal_cell_death0.52166942
150MP0001765_abnormal_ion_homeostasis0.51909301
151MP0001764_abnormal_homeostasis0.51615964
152MP0005584_abnormal_enzyme/coenzyme_acti0.49705272
153MP0000383_abnormal_hair_follicle0.48920787
154MP0004270_analgesia0.48136498
155MP0003183_abnormal_peptide_metabolism0.48087888
156MP0003283_abnormal_digestive_organ0.47982194
157MP0000955_abnormal_spinal_cord0.45281655
158MP0002405_respiratory_system_inflammati0.44448736
159MP0003632_abnormal_nervous_system0.44264795
160MP0000613_abnormal_salivary_gland0.43955162
161MP0000647_abnormal_sebaceous_gland0.43399948
162MP0003786_premature_aging0.43197632
163MP0006035_abnormal_mitochondrial_morpho0.43158536
164MP0000026_abnormal_inner_ear0.43133459
165MP0001216_abnormal_epidermal_layer0.42717725
166MP0005448_abnormal_energy_balance0.42380583

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.11801640
2Elfin facies (HP:0004428)7.82019423
3Hyperacusis (HP:0010780)7.75712583
4Overriding aorta (HP:0002623)7.67676563
5Renovascular hypertension (HP:0100817)7.50704143
6Dynein arm defect of respiratory motile cilia (HP:0012255)7.25426079
7Absent/shortened dynein arms (HP:0200106)7.25426079
8Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)6.52299103
9Renal duplication (HP:0000075)6.49780940
10Flat cornea (HP:0007720)6.49181497
11Abnormal respiratory motile cilium morphology (HP:0005938)6.39954530
12Abnormal respiratory epithelium morphology (HP:0012253)6.39954530
13Insomnia (HP:0100785)6.38720356
14Sensory axonal neuropathy (HP:0003390)6.34182253
15Abnormal respiratory motile cilium physiology (HP:0012261)6.21955009
16Rhinitis (HP:0012384)5.92577251
17Abnormality of the diencephalon (HP:0010662)5.14065449
18Abnormal ciliary motility (HP:0012262)5.02634929
19Chronic bronchitis (HP:0004469)4.83635343
20Chronic otitis media (HP:0000389)4.42706495
21Increased nuchal translucency (HP:0010880)4.37564075
22Nasal polyposis (HP:0100582)4.24069651
23Chronic sinusitis (HP:0011109)3.96046178
24Curly hair (HP:0002212)3.94683128
25Bladder diverticulum (HP:0000015)3.92187121
26Bowel diverticulosis (HP:0005222)3.86060473
27Megalocornea (HP:0000485)3.63640272
28Abnormality of the nasal mucosa (HP:0000433)3.48712570
29Hyporeflexia of lower limbs (HP:0002600)3.48387956
30Abnormality of the carotid arteries (HP:0005344)3.45714892
31Areflexia of lower limbs (HP:0002522)3.11917539
32Ependymoma (HP:0002888)3.05499815
33True hermaphroditism (HP:0010459)2.99385819
34Medial flaring of the eyebrow (HP:0010747)2.98778017
35Bronchiectasis (HP:0002110)2.98540562
36Congenital primary aphakia (HP:0007707)2.92278578
37Gait imbalance (HP:0002141)2.90552186
38Pancreatic fibrosis (HP:0100732)2.90132270
39Hypercalciuria (HP:0002150)2.87354268
40Agnosia (HP:0010524)2.84543799
41Limb hypertonia (HP:0002509)2.84439663
42Abnormality of the astrocytes (HP:0100707)2.73531666
43Astrocytoma (HP:0009592)2.73531666
44Hypercalcemia (HP:0003072)2.72055781
45Medulloblastoma (HP:0002885)2.62911257
46Patellar dislocation (HP:0002999)2.61787003
47Tubulointerstitial nephritis (HP:0001970)2.61409494
48Occipital encephalocele (HP:0002085)2.57336510
49Bronchitis (HP:0012387)2.56907559
50Obsessive-compulsive behavior (HP:0000722)2.56889324
51Abnormality of the gastric mucosa (HP:0004295)2.56260116
52Nephrogenic diabetes insipidus (HP:0009806)2.56178253
53Volvulus (HP:0002580)2.44869565
54Posterior embryotoxon (HP:0000627)2.43806397
55Diaphragmatic weakness (HP:0009113)2.43649900
56Oligodactyly (hands) (HP:0001180)2.43031777
57Truncal ataxia (HP:0002078)2.42353290
58Postaxial foot polydactyly (HP:0001830)2.41906886
59Rhabdomyosarcoma (HP:0002859)2.37323952
60Glioma (HP:0009733)2.33848950
61Abnormality of the line of Schwalbe (HP:0008048)2.33336675
62Poor coordination (HP:0002370)2.30448672
63Cystic liver disease (HP:0006706)2.25888030
64Cardiomegaly (HP:0001640)2.25813210
65Male infertility (HP:0003251)2.25359246
66Pancreatic cysts (HP:0001737)2.23974397
67Infertility (HP:0000789)2.18927982
68Abnormality of the labia minora (HP:0012880)2.18905559
69Nephronophthisis (HP:0000090)2.18746021
70Bifid scrotum (HP:0000048)2.16458025
71Abnormality of the endocardium (HP:0004306)2.15629485
72Nephrocalcinosis (HP:0000121)2.15181233
73Periorbital edema (HP:0100539)2.09442817
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.08460036
75Intestinal atresia (HP:0011100)2.07687668
76Pointed chin (HP:0000307)2.07424403
77Hypoplastic toenails (HP:0001800)2.06391318
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04999177
79Sclerocornea (HP:0000647)2.01220119
80Facial edema (HP:0000282)2.01213711
81Hand muscle atrophy (HP:0009130)2.01128907
82Anencephaly (HP:0002323)1.99987351
83Oligodactyly (HP:0012165)1.98696867
84Preaxial hand polydactyly (HP:0001177)1.97663172
85Hallux valgus (HP:0001822)1.97452933
86Thyroid-stimulating hormone excess (HP:0002925)1.92441420
87Gastrointestinal atresia (HP:0002589)1.90205875
88Overlapping toe (HP:0001845)1.90192814
89Vaginal atresia (HP:0000148)1.89985683
90Median cleft lip (HP:0000161)1.89800243
91Focal motor seizures (HP:0011153)1.85847141
92Adducted thumb (HP:0001181)1.85773594
93Arnold-Chiari malformation (HP:0002308)1.84798442
94Morphological abnormality of the pyramidal tract (HP:0002062)1.82419506
95Tubular atrophy (HP:0000092)1.82313148
96Azoospermia (HP:0000027)1.81321022
97Genital tract atresia (HP:0001827)1.81206375
98Recurrent otitis media (HP:0000403)1.80886939
99Impaired vibration sensation in the lower limbs (HP:0002166)1.80351010
100Tongue fasciculations (HP:0001308)1.80062964
101Annular pancreas (HP:0001734)1.80053121
102Bifid tongue (HP:0010297)1.79921444
103Precocious puberty (HP:0000826)1.77683229
104Deviation of the hallux (HP:0010051)1.76829197
105Absent epiphyses (HP:0010577)1.76762218
106Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76762218
107Polycystic ovaries (HP:0000147)1.74603400
108Absent eyebrow (HP:0002223)1.73099695
109Postaxial hand polydactyly (HP:0001162)1.71262059
110Carpal bone hypoplasia (HP:0001498)1.70575253
111Recurrent sinusitis (HP:0011108)1.69186361
112Hyperglycinemia (HP:0002154)1.68650994
113Abnormality of midbrain morphology (HP:0002418)1.68629785
114Molar tooth sign on MRI (HP:0002419)1.68629785
115Polycystic kidney dysplasia (HP:0000113)1.68406458
116Supernumerary spleens (HP:0009799)1.68292559
117Spina bifida occulta (HP:0003298)1.66941589
118Slow saccadic eye movements (HP:0000514)1.65537070
119Papillary thyroid carcinoma (HP:0002895)1.65347586
120Renal hypoplasia (HP:0000089)1.64714941
121Muscle fibrillation (HP:0010546)1.64281215
122Hyperglycinuria (HP:0003108)1.63340374
123Steppage gait (HP:0003376)1.63173579
124Retinal dysplasia (HP:0007973)1.63034361
125Hyperventilation (HP:0002883)1.62691441
126Male pseudohermaphroditism (HP:0000037)1.60446186
127Radioulnar synostosis (HP:0002974)1.59746093
128Neoplasm of striated muscle (HP:0009728)1.59631648
129Esophageal atresia (HP:0002032)1.59116759
130Abnormality of the labia (HP:0000058)1.58724582
131Anosmia (HP:0000458)1.58611266
132Deep philtrum (HP:0002002)1.57719292
133Broad distal phalanx of finger (HP:0009836)1.57616273
134Aplasia/Hypoplasia of the lens (HP:0008063)1.57369121
135Abnormality of the renal cortex (HP:0011035)1.57239273
136Abnormality of the renal medulla (HP:0100957)1.56851345
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.55555946
138Type II lissencephaly (HP:0007260)1.54250251
139Abnormality of the nasal septum (HP:0000419)1.52682641
140Abnormal eating behavior (HP:0100738)1.52303697
141Pheochromocytoma (HP:0002666)1.49956388
142Neuroblastoma (HP:0003006)1.49314835
143Primitive neuroectodermal tumor (HP:0030065)1.49314835
144Neuroblastic tumors (HP:0004376)1.49314835
145Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.49314835
146Oculomotor apraxia (HP:0000657)1.49208036
147Abnormal drinking behavior (HP:0030082)1.48821358
148Polydipsia (HP:0001959)1.48821358
149Fatigue (HP:0012378)1.48411263
150Sacral dimple (HP:0000960)1.48180414
151Congenital hepatic fibrosis (HP:0002612)1.47924182
152Biliary tract neoplasm (HP:0100574)1.46745966
153Cutaneous finger syndactyly (HP:0010554)1.46605284
154Lower limb asymmetry (HP:0100559)1.45905817
155Dysdiadochokinesis (HP:0002075)1.44888071
156Abnormal spermatogenesis (HP:0008669)1.44609634
157Bell-shaped thorax (HP:0001591)1.44019870
158Chromosomal breakage induced by crosslinking agents (HP:0003221)1.43910400
159Holoprosencephaly (HP:0001360)1.43870968
160Hypoplastic labia majora (HP:0000059)1.42810416
161Breech presentation (HP:0001623)1.42111612
162Split foot (HP:0001839)1.41293414
163Impaired smooth pursuit (HP:0007772)1.40571111
164Chronic hepatic failure (HP:0100626)1.38447461
165Pes planus (HP:0001763)1.33888488
166Ankyloglossia (HP:0010296)1.33810701
167Recurrent urinary tract infections (HP:0000010)1.33617161
168Limb ataxia (HP:0002070)1.33592903
169Facial hemangioma (HP:0000329)1.33499380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.94498081
2PDK46.94498081
3PNCK5.06738662
4EPHA44.53571402
5YES14.47230392
6PDK24.42022540
7MAP3K93.75882494
8AKT33.34067094
9GRK12.79419960
10TTK2.72278558
11EPHB22.54310559
12MAPK152.46405976
13PLK42.45184661
14RIPK12.34337387
15PHKG12.23608422
16PHKG22.23608422
17BRSK22.20378241
18BMPR1B2.17474214
19MST42.17087699
20TYK22.14572397
21MARK12.08756847
22PDGFRB2.05552183
23TSSK62.02135237
24CASK1.91773364
25NTRK21.88672213
26ERBB21.86892347
27NTRK31.77359651
28FGFR21.75319692
29STK161.67783683
30TAF11.62271004
31ZAK1.54061858
32PKN11.49685477
33STK391.49033368
34BRD41.26479833
35PASK1.23721725
36PRKD31.23584997
37CDK121.21716886
38WEE11.21075447
39VRK11.15789444
40HCK1.14620539
41MAPK131.09356383
42CAMK1G1.07534415
43EPHA21.06866137
44NEK61.05208938
45MKNK21.04092387
46CCNB11.03772732
47IRAK11.01972490
48MET1.01455220
49BRSK11.01294551
50BRAF0.97958460
51NME10.97051303
52ZAP700.94869639
53CDK70.94320453
54SRPK10.92592928
55BTK0.91308693
56TYRO30.90460607
57SGK20.88694145
58PBK0.86881830
59INSRR0.85461784
60MINK10.82843070
61NEK10.81569962
62OXSR10.80222328
63SYK0.79487137
64WNK40.78109114
65PIK3CA0.72480585
66MAP2K70.72117776
67CHEK20.71937132
68UHMK10.69452117
69FER0.68709909
70PLK10.66051390
71NLK0.65959309
72BUB10.64874531
73FGFR10.64146587
74MAP3K40.64124333
75TAOK10.63596902
76MAP3K20.63263303
77RET0.62872371
78CDK90.62592362
79SGK4940.61546362
80SGK2230.61546362
81KSR10.61080679
82MAPK70.60361985
83CDK190.59318148
84MELK0.58297789
85DMPK0.57814608
86STK30.57431083
87CSNK1E0.57429675
88EGFR0.57093164
89PRKCE0.56778772
90ROCK10.54858985
91DDR20.54728253
92CDK30.54296386
93BCR0.53801051
94PLK30.53584123
95PLK20.52724537
96STK38L0.52627814
97CAMK10.52541429
98MAP3K30.52361573
99ROCK20.50062692
100TGFBR10.50023100
101TRIM280.49547525
102TNK20.49276596
103AURKA0.49118526
104PRKDC0.48750967
105NEK20.48023936
106EIF2AK30.47269918
107MKNK10.46855722
108PRKCG0.46022344
109CHEK10.45372484
110ABL20.43386801
111IKBKE0.43002002
112PRKAA20.42977679
113LMTK20.42205500
114PRKG10.42126058
115CDC70.41892919
116EPHA30.41414866
117PAK60.41044245
118MAP2K10.40826429
119HIPK20.40122593
120ACVR1B0.39956575
121SGK30.39409988
122JAK30.39018804
123ATR0.38655782
124PINK10.37789566
125CDK50.37576820
126BMPR20.37406470
127SGK10.37294018
128MAPKAPK20.36562091
129RPS6KA50.36416694
130DYRK20.36236194
131BMX0.35463087
132MTOR0.34990781
133PDK10.34480033
134MAP2K30.34430519
135MAPK100.33979403
136CAMK2A0.33626102
137ABL10.32898039
138LCK0.32642834
139TEC0.32500082
140PRKCZ0.30175905
141PRKD20.29316096
142AURKB0.26135938
143STK40.26118262
144DYRK30.25387058
145MAP3K10.22278748
146FGFR40.20093302
147PRKCI0.19216443
148ATM0.18644553
149MARK20.18478659
150IGF1R0.17813176
151WNK30.17596792
152TNIK0.16954148
153ERBB30.16848121
154KIT0.16464115
155MAP2K60.15938180
156PIK3CG0.14239996
157CAMKK20.14204775
158RPS6KA20.14079701
159INSR0.12955110
160FLT30.12040159
161PIM20.11592214
162CDK10.10945555
163TESK10.10807617
164MAP3K60.09629152
165DYRK1B0.09493219
166MAP2K20.08968618

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose phosphate pathway_Homo sapiens_hsa000305.54951744
2Homologous recombination_Homo sapiens_hsa034404.68037432
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.55000936
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.35375540
5Basal transcription factors_Homo sapiens_hsa030223.32572220
6Selenocompound metabolism_Homo sapiens_hsa004503.13645186
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005123.05398926
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.95311364
9N-Glycan biosynthesis_Homo sapiens_hsa005102.78965940
10Fanconi anemia pathway_Homo sapiens_hsa034602.55177564
11Histidine metabolism_Homo sapiens_hsa003402.52863029
12beta-Alanine metabolism_Homo sapiens_hsa004102.36357186
13Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.28479921
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19692959
15Non-homologous end-joining_Homo sapiens_hsa034502.19031074
16Phosphatidylinositol signaling system_Homo sapiens_hsa040701.86848928
17Dorso-ventral axis formation_Homo sapiens_hsa043201.85537830
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.79081479
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.79057055
20Systemic lupus erythematosus_Homo sapiens_hsa053221.71606609
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65563195
22Wnt signaling pathway_Homo sapiens_hsa043101.65538097
23DNA replication_Homo sapiens_hsa030301.61346571
24Linoleic acid metabolism_Homo sapiens_hsa005911.58602041
25Nicotine addiction_Homo sapiens_hsa050331.58111475
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.58022431
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56402879
28Basal cell carcinoma_Homo sapiens_hsa052171.54313509
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.42731451
30Gastric acid secretion_Homo sapiens_hsa049711.41950572
31Caffeine metabolism_Homo sapiens_hsa002321.35557908
32Axon guidance_Homo sapiens_hsa043601.35017773
33Insulin secretion_Homo sapiens_hsa049111.34537709
34Hedgehog signaling pathway_Homo sapiens_hsa043401.32212081
35Protein export_Homo sapiens_hsa030601.29081506
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.28660356
37Glucagon signaling pathway_Homo sapiens_hsa049221.27165941
38Inositol phosphate metabolism_Homo sapiens_hsa005621.24280966
39Arginine and proline metabolism_Homo sapiens_hsa003301.23266662
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.21519822
41Phenylalanine metabolism_Homo sapiens_hsa003601.20823611
42Biosynthesis of amino acids_Homo sapiens_hsa012301.20440540
43Nucleotide excision repair_Homo sapiens_hsa034201.20024425
44ErbB signaling pathway_Homo sapiens_hsa040121.19624819
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19426350
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18580318
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18255168
48Chemical carcinogenesis_Homo sapiens_hsa052041.17519297
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17053485
50Hippo signaling pathway_Homo sapiens_hsa043901.15331502
51Sulfur metabolism_Homo sapiens_hsa009201.14165841
52Steroid biosynthesis_Homo sapiens_hsa001001.13586539
53Alcoholism_Homo sapiens_hsa050341.13343189
54Salivary secretion_Homo sapiens_hsa049701.12022901
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11220432
56Chronic myeloid leukemia_Homo sapiens_hsa052201.09220923
57Peroxisome_Homo sapiens_hsa041461.06919448
58Lysine degradation_Homo sapiens_hsa003101.06588365
59Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04941861
60Glycerolipid metabolism_Homo sapiens_hsa005611.04746729
61Phototransduction_Homo sapiens_hsa047441.02551865
62Vitamin B6 metabolism_Homo sapiens_hsa007501.00996831
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00282650
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.99396190
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99331801
66Tight junction_Homo sapiens_hsa045300.99111523
67Spliceosome_Homo sapiens_hsa030400.98855768
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97222529
69Legionellosis_Homo sapiens_hsa051340.93743697
70Ether lipid metabolism_Homo sapiens_hsa005650.91441869
71Taste transduction_Homo sapiens_hsa047420.91371476
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88985351
73PPAR signaling pathway_Homo sapiens_hsa033200.88667340
74Glutathione metabolism_Homo sapiens_hsa004800.88611668
75Butanoate metabolism_Homo sapiens_hsa006500.87357305
76Nitrogen metabolism_Homo sapiens_hsa009100.86994854
77Purine metabolism_Homo sapiens_hsa002300.86394321
78Fatty acid degradation_Homo sapiens_hsa000710.85806691
79Retinol metabolism_Homo sapiens_hsa008300.85536901
80Pyruvate metabolism_Homo sapiens_hsa006200.85416230
81Cocaine addiction_Homo sapiens_hsa050300.84521353
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84382562
83ABC transporters_Homo sapiens_hsa020100.84180444
84TGF-beta signaling pathway_Homo sapiens_hsa043500.83168814
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82162493
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78478444
87RNA transport_Homo sapiens_hsa030130.78008342
88p53 signaling pathway_Homo sapiens_hsa041150.77632707
89Circadian entrainment_Homo sapiens_hsa047130.77475288
90Folate biosynthesis_Homo sapiens_hsa007900.75740093
91Adherens junction_Homo sapiens_hsa045200.75545057
92Insulin signaling pathway_Homo sapiens_hsa049100.73968168
93Huntingtons disease_Homo sapiens_hsa050160.71556949
94Oocyte meiosis_Homo sapiens_hsa041140.71390488
95Vitamin digestion and absorption_Homo sapiens_hsa049770.68174137
96GABAergic synapse_Homo sapiens_hsa047270.68087216
97Circadian rhythm_Homo sapiens_hsa047100.68074098
98Melanogenesis_Homo sapiens_hsa049160.66969225
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65121318
100Olfactory transduction_Homo sapiens_hsa047400.62363849
101Fatty acid biosynthesis_Homo sapiens_hsa000610.61315418
102Calcium signaling pathway_Homo sapiens_hsa040200.60993211
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60629656
104Carbon metabolism_Homo sapiens_hsa012000.58575346
105Arginine biosynthesis_Homo sapiens_hsa002200.57945584
106cAMP signaling pathway_Homo sapiens_hsa040240.56690981
107Prolactin signaling pathway_Homo sapiens_hsa049170.56531968
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.56087350
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55997860
110Type I diabetes mellitus_Homo sapiens_hsa049400.55277393
111Amphetamine addiction_Homo sapiens_hsa050310.54877268
112Serotonergic synapse_Homo sapiens_hsa047260.54104776
113Sphingolipid metabolism_Homo sapiens_hsa006000.51021169
114Morphine addiction_Homo sapiens_hsa050320.50108512
115Metabolic pathways_Homo sapiens_hsa011000.49902981
116Thyroid hormone synthesis_Homo sapiens_hsa049180.49598527
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.49405125
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49027483
119Herpes simplex infection_Homo sapiens_hsa051680.49010847
120Tyrosine metabolism_Homo sapiens_hsa003500.48081255
121Tryptophan metabolism_Homo sapiens_hsa003800.47468913
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47210202
123Mismatch repair_Homo sapiens_hsa034300.46820574
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46600463
125Cell cycle_Homo sapiens_hsa041100.44654628
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.44566701
127Arachidonic acid metabolism_Homo sapiens_hsa005900.42269725
128Viral carcinogenesis_Homo sapiens_hsa052030.41347932
129Synaptic vesicle cycle_Homo sapiens_hsa047210.40370242
130Pyrimidine metabolism_Homo sapiens_hsa002400.40157842
131Antigen processing and presentation_Homo sapiens_hsa046120.37048827
132Type II diabetes mellitus_Homo sapiens_hsa049300.33492553
133mRNA surveillance pathway_Homo sapiens_hsa030150.33464384
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33193872
135Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32533772
136Collecting duct acid secretion_Homo sapiens_hsa049660.32026377
137Glutamatergic synapse_Homo sapiens_hsa047240.31922258
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31181314
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.30541599
140Fructose and mannose metabolism_Homo sapiens_hsa000510.28959913
141RNA degradation_Homo sapiens_hsa030180.28533026
142Base excision repair_Homo sapiens_hsa034100.26493857
143T cell receptor signaling pathway_Homo sapiens_hsa046600.23512608
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21747360
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21156877
146Dopaminergic synapse_Homo sapiens_hsa047280.19928783
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.18814978
148Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18790557
149Propanoate metabolism_Homo sapiens_hsa006400.18690317
150Primary immunodeficiency_Homo sapiens_hsa053400.17452719
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.17127709
152Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16061087
153Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.15703949
154Ovarian steroidogenesis_Homo sapiens_hsa049130.14461513
155Measles_Homo sapiens_hsa051620.14158048
156MAPK signaling pathway_Homo sapiens_hsa040100.13321016
157Pathways in cancer_Homo sapiens_hsa052000.12025518

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