STPG3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.89701918
2axonemal dynein complex assembly (GO:0070286)9.72302320
3plasma membrane fusion (GO:0045026)9.67422338
4epithelial cilium movement (GO:0003351)9.54710188
5motile cilium assembly (GO:0044458)9.02794267
6reproduction (GO:0000003)9.01255373
7regulation of cilium movement (GO:0003352)9.01124190
8cilium or flagellum-dependent cell motility (GO:0001539)8.74934550
9cilium movement (GO:0003341)7.75422695
10sperm capacitation (GO:0048240)7.42750688
11negative regulation of inclusion body assembly (GO:0090084)7.38156051
12synaptonemal complex organization (GO:0070193)7.30012116
13male meiosis (GO:0007140)7.20031380
14synaptonemal complex assembly (GO:0007130)7.18330332
15piRNA metabolic process (GO:0034587)7.18078531
16single fertilization (GO:0007338)7.16390701
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.09073794
18spermatogenesis (GO:0007283)6.79055197
19male gamete generation (GO:0048232)6.76604166
20organic cation transport (GO:0015695)6.72121789
21response to pheromone (GO:0019236)6.61578430
22phosphatidylethanolamine biosynthetic process (GO:0006646)6.59127776
23microtubule depolymerization (GO:0007019)6.47998161
24rRNA methylation (GO:0031167)6.25657248
25gamete generation (GO:0007276)6.22272192
26regulation of inclusion body assembly (GO:0090083)6.15686380
27fertilization (GO:0009566)6.15108201
28phosphatidylethanolamine metabolic process (GO:0046337)5.96477552
29germ cell development (GO:0007281)5.51616491
30calcium ion-dependent exocytosis (GO:0017156)5.42869926
31chromosome condensation (GO:0030261)5.42037537
32regulation of microtubule-based movement (GO:0060632)5.40752384
33cellular process involved in reproduction in multicellular organism (GO:0022412)5.40358942
34DNA packaging (GO:0006323)5.21967532
35cellular ketone body metabolic process (GO:0046950)5.14715127
36ventricular system development (GO:0021591)5.12631298
37male meiosis I (GO:0007141)5.08243790
38rRNA modification (GO:0000154)5.03377050
39microtubule severing (GO:0051013)5.01218711
40cell recognition (GO:0008037)4.93916123
41multicellular organismal reproductive process (GO:0048609)4.89067233
42chromosome organization involved in meiosis (GO:0070192)4.86775153
43glycerol ether metabolic process (GO:0006662)4.83620195
44spermatid nucleus differentiation (GO:0007289)4.67880383
45positive regulation of Rab GTPase activity (GO:0032851)4.60234313
46regulation of Rab GTPase activity (GO:0032313)4.60234313
47DNA methylation involved in gamete generation (GO:0043046)4.54083639
48seminiferous tubule development (GO:0072520)4.46485545
49ether metabolic process (GO:0018904)4.46203750
50ketone body metabolic process (GO:1902224)4.45248957
51meiotic nuclear division (GO:0007126)4.42254072
52chaperone-mediated protein complex assembly (GO:0051131)4.41939640
53regulation of histone H3-K27 methylation (GO:0061085)4.37484135
54left/right pattern formation (GO:0060972)4.27319866
55histone H3-K9 demethylation (GO:0033169)4.20800157
56meiosis I (GO:0007127)4.13972357
57single strand break repair (GO:0000012)4.11753928
58regulation of ARF GTPase activity (GO:0032312)4.01685352
59protein polyglutamylation (GO:0018095)4.01007241
60sexual reproduction (GO:0019953)4.00707577
61response to acidic pH (GO:0010447)3.98254683
62histone H4 deacetylation (GO:0070933)3.96084143
63protein targeting to Golgi (GO:0000042)3.95354082
64multicellular organismal development (GO:0007275)3.90932910
65retrograde transport, vesicle recycling within Golgi (GO:0000301)3.81841259
66establishment of protein localization to Golgi (GO:0072600)3.80502802
67cell-cell junction maintenance (GO:0045217)3.75517687
68cellular response to pH (GO:0071467)3.75187479
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.67663146
70genitalia morphogenesis (GO:0035112)3.67216136
71regulation of spindle checkpoint (GO:0090231)3.65838162
72protein refolding (GO:0042026)3.53738393
73regulation of transcription involved in cell fate commitment (GO:0060850)3.51008120
74coenzyme catabolic process (GO:0009109)3.49448539
75cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.46889831
76insulin-like growth factor receptor signaling pathway (GO:0048009)3.46381627
77imidazole-containing compound metabolic process (GO:0052803)3.44674389
78microtubule polymerization or depolymerization (GO:0031109)3.44381483
79meiotic cell cycle (GO:0051321)3.41990343
80opsonization (GO:0008228)3.34327813
81negative regulation of granulocyte differentiation (GO:0030853)3.32493418
82histone H3 deacetylation (GO:0070932)3.29807535
83sequestering of actin monomers (GO:0042989)3.27251273
84mitotic sister chromatid cohesion (GO:0007064)3.24186054
85tooth mineralization (GO:0034505)3.18051747
86protein K11-linked deubiquitination (GO:0035871)3.16953584
87regulation of T-helper 2 cell differentiation (GO:0045628)3.15405095
88nucleus organization (GO:0006997)3.13781432
89glycolytic process (GO:0006096)3.13587455
90interferon-gamma secretion (GO:0072643)3.12692055
91monoubiquitinated protein deubiquitination (GO:0035520)3.12284895
92amino-acid betaine transport (GO:0015838)3.10558551
93carnitine transport (GO:0015879)3.10558551
94RNA localization (GO:0006403)3.06767549
95negative regulation of Rho protein signal transduction (GO:0035024)3.06524958
96regulation of interleukin-13 production (GO:0032656)3.06233489
97negative regulation of gene expression, epigenetic (GO:0045814)3.05955978
98peptide catabolic process (GO:0043171)3.05872831
99establishment of apical/basal cell polarity (GO:0035089)3.04002378
100DNA conformation change (GO:0071103)3.03163979
101positive regulation of protein kinase C signaling (GO:0090037)3.02642489
102protein localization to cilium (GO:0061512)3.02622604
103negative regulation of histone methylation (GO:0031061)3.02462999
104chromatin silencing (GO:0006342)2.99301911
105RNA destabilization (GO:0050779)2.94484102
106centriole assembly (GO:0098534)2.94226301
107meiotic cell cycle process (GO:1903046)2.91135893
108carnitine transmembrane transport (GO:1902603)2.91034909
109glutathione biosynthetic process (GO:0006750)2.90711249
110positive regulation of histone deacetylation (GO:0031065)2.90114555
111synapsis (GO:0007129)2.89248336
112positive regulation of macrophage activation (GO:0043032)2.88687175
113nucleoside diphosphate phosphorylation (GO:0006165)2.86550691
114negative regulation of organelle assembly (GO:1902116)2.86390231
115protein localization to Golgi apparatus (GO:0034067)2.86340647
116polyamine biosynthetic process (GO:0006596)2.84202674
117alditol metabolic process (GO:0019400)2.82145672
118cranial nerve morphogenesis (GO:0021602)2.80874225
119phosphatidylcholine biosynthetic process (GO:0006656)2.80636183
120cell junction maintenance (GO:0034331)2.76927837
121polyol catabolic process (GO:0046174)2.76155783
1224-hydroxyproline metabolic process (GO:0019471)2.76064557
123centriole replication (GO:0007099)2.74638573
124peptidyl-threonine dephosphorylation (GO:0035970)2.74225710
125protein depolymerization (GO:0051261)2.73113942
126negative regulation of cell size (GO:0045792)2.71632633
127regulation of somitogenesis (GO:0014807)2.71154473
128cerebral cortex neuron differentiation (GO:0021895)2.69600988
129complement activation, alternative pathway (GO:0006957)2.67728255
130membrane protein intracellular domain proteolysis (GO:0031293)2.67727014
131mitochondrion degradation (GO:0000422)2.67555611
132mitotic G1 DNA damage checkpoint (GO:0031571)2.67402462
133microtubule-based movement (GO:0007018)2.67206868
134face development (GO:0060324)2.66681069
135regulation of cilium assembly (GO:1902017)2.65873982
136outflow tract septum morphogenesis (GO:0003148)2.64977724
137GTP biosynthetic process (GO:0006183)2.61457732
138cilium organization (GO:0044782)2.60290976
139peptidyl-glutamic acid modification (GO:0018200)2.59556948
140intraciliary transport (GO:0042073)2.56861910
141gene silencing by RNA (GO:0031047)2.56314999
142gene silencing (GO:0016458)2.52053941
143axoneme assembly (GO:0035082)2.51830515
144protein-DNA complex disassembly (GO:0032986)2.50569721
145nucleosome disassembly (GO:0006337)2.50569721
146cilium morphogenesis (GO:0060271)2.49527801
147sperm motility (GO:0030317)14.0265208
148fusion of sperm to egg plasma membrane (GO:0007342)12.7115384
149cell wall macromolecule metabolic process (GO:0044036)12.3615822
150cell wall macromolecule catabolic process (GO:0016998)12.3615822
151acrosome reaction (GO:0007340)12.3150330
152sperm-egg recognition (GO:0035036)11.5484616
153acrosome assembly (GO:0001675)11.1861580
154binding of sperm to zona pellucida (GO:0007339)10.5664234
155multicellular organism reproduction (GO:0032504)10.4426902
156cell-cell recognition (GO:0009988)10.3246418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.87292313
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.36062414
3EZH2_22144423_ChIP-Seq_EOC_Human4.07835351
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.88071265
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.65193988
6LXR_22292898_ChIP-Seq_THP-1_Human3.53171420
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.37057853
8STAT6_21828071_ChIP-Seq_BEAS2B_Human3.11168796
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.75343130
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.67835200
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.63741254
12P68_20966046_ChIP-Seq_HELA_Human2.59539317
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.59314366
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.51906643
15SMC4_20622854_ChIP-Seq_HELA_Human2.40190601
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29278373
17VDR_22108803_ChIP-Seq_LS180_Human2.28036548
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.25541177
19CTCF_27219007_Chip-Seq_Bcells_Human2.24347862
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12167851
21E2F1_20622854_ChIP-Seq_HELA_Human2.02849095
22FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98267518
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.97326424
24DROSHA_22980978_ChIP-Seq_HELA_Human1.96410490
25SA1_27219007_Chip-Seq_ERYTHROID_Human1.90241780
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89284447
27ZNF274_21170338_ChIP-Seq_K562_Hela1.85369883
28KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83881612
29RACK7_27058665_Chip-Seq_MCF-7_Human1.82503795
30SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.80648664
31TCF7_22412390_ChIP-Seq_EML_Mouse1.80093832
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.78729359
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76304382
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75481272
35TP63_22573176_ChIP-Seq_HFKS_Human1.75080406
36SOX2_22085726_ChIP-Seq_NPCs_Mouse1.70619771
37STAT1_17558387_ChIP-Seq_HELA_Human1.70304999
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69950802
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.68629647
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67809240
41FLI1_27457419_Chip-Seq_LIVER_Mouse1.67309177
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.66735238
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.65958738
44KDM2B_26808549_Chip-Seq_DND41_Human1.65375704
45VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.61376817
46RAC3_21632823_ChIP-Seq_H3396_Human1.61362368
47TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60711668
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.60653426
49EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58428019
50MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.57892811
51KDM2B_26808549_Chip-Seq_K562_Human1.57696133
52ERA_21632823_ChIP-Seq_H3396_Human1.57307834
53FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.54977307
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54692044
55SA1_27219007_Chip-Seq_Bcells_Human1.53809310
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52092490
57WDR5_24793694_ChIP-Seq_LNCAP_Human1.49833771
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.46789557
59MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.45620000
60P300_27268052_Chip-Seq_Bcells_Human1.44724298
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42535944
62CREB1_26743006_Chip-Seq_LNCaP_Human1.40185595
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39978325
64SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39708914
65PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.38330476
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.37715942
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36460491
68LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34766800
69VDR_21846776_ChIP-Seq_THP-1_Human1.34102266
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34083555
71P53_21459846_ChIP-Seq_SAOS-2_Human1.33751358
72GATA1_19941826_ChIP-Seq_K562_Human1.33572919
73TAL1_26923725_Chip-Seq_HPCs_Mouse1.33535191
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32083631
75SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31815203
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31072854
77GATA3_21867929_ChIP-Seq_TH1_Mouse1.30352777
78NCOR1_26117541_ChIP-Seq_K562_Human1.30050195
79SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29934168
80TP53_22127205_ChIP-Seq_IMR90_Human1.29683634
81CTCF_21964334_Chip-Seq_Bcells_Human1.29433170
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.29399594
83CBP_20019798_ChIP-Seq_JUKART_Human1.28941353
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28941353
85CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28750307
86KDM2B_26808549_Chip-Seq_REH_Human1.27962132
87SPI1_26923725_Chip-Seq_HPCs_Mouse1.27788596
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.25727636
89RAD21_21589869_ChIP-Seq_MESCs_Mouse1.25701407
90GF1_26923725_Chip-Seq_HPCs_Mouse1.25287004
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24981414
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24424632
93OCT4_19829295_ChIP-Seq_ESCs_Human1.23418023
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23350587
95MYC_22102868_ChIP-Seq_BL_Human1.22988806
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22641905
97CTCF_20526341_ChIP-Seq_ESCs_Human1.22586993
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22473709
99YY1_22570637_ChIP-Seq_MALME-3M_Human1.22273579
100TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21877057
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.21228161
102RUNX1_26923725_Chip-Seq_HPCs_Mouse1.20741943
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20727559
104RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19873370
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19847014
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19096054
107SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18531735
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17945387
109OCT4_20526341_ChIP-Seq_ESCs_Human1.17183689
110EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16945319
111RARA_24833708_ChIP-Seq_LIVER_Mouse1.14982051
112ERG_20517297_ChIP-Seq_VCAP_Human1.13420824
113FLI1_21867929_ChIP-Seq_TH2_Mouse1.13392557
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13297455
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13080094
116SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12679194
117REST_21632747_ChIP-Seq_MESCs_Mouse1.12657161
118FOXP1_21924763_ChIP-Seq_HESCs_Human1.12642978
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.12511521
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12414041
121MAF_26560356_Chip-Seq_TH2_Human1.12078485
122SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11774597
123GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11321542
124ERG_21242973_ChIP-ChIP_JURKAT_Human1.10973010
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.10274152
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10103464
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09595133
128ELF1_20517297_ChIP-Seq_JURKAT_Human1.09111782
129TAF2_19829295_ChIP-Seq_ESCs_Human1.08497247
130KLF5_25053715_ChIP-Seq_YYC3_Human1.07960437
131TDRD3_21172665_ChIP-Seq_MCF-7_Human1.07931922
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07788565
133BCOR_27268052_Chip-Seq_Bcells_Human1.07768820
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06938375
135LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06813289
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.06657918
137ETS1_21867929_ChIP-Seq_TH2_Mouse1.06497165
138CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06329549
139NFE2_27457419_Chip-Seq_LIVER_Mouse1.05843073
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05611196
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05611196
142JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05524211
143ESET_19884257_ChIP-Seq_ESCs_Mouse1.05455765
144ESR2_21235772_ChIP-Seq_MCF-7_Human1.04484053
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03797364
146MYC_27129775_Chip-Seq_CORNEA_Mouse1.02241044
147DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01658809
148PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01111743
149SOX11_22085726_ChIP-Seq_ESNs_Mouse1.00634918
150KDM2B_26808549_Chip-Seq_JURKAT_Human1.00360220
151PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99579786
152NANOG_20526341_ChIP-Seq_ESCs_Human0.98594107
153DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97900049
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.97429727
155SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96146480
156RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95998115
157KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.95917578
158TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95824845
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95473354
160KLF4_19829295_ChIP-Seq_ESCs_Human0.94838233
161MYC_19829295_ChIP-Seq_ESCs_Human0.94788592
162FLI1_21867929_ChIP-Seq_CD8_Mouse0.94478145
163SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93942134
164PHF8_20622854_ChIP-Seq_HELA_Human0.92807811
165PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91476868
166SOX2_21211035_ChIP-Seq_LN229_Human0.90788038
167TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90780554
168NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90410137
169CTCF_26484167_Chip-Seq_Bcells_Mouse0.89808099
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.89085825
171CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89034472
172SUZ12_27294783_Chip-Seq_NPCs_Mouse0.88298467
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88157914
174BCL6_27268052_Chip-Seq_Bcells_Human0.86190501
175SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85401600
176NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.83689337
177ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83433690
178KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.82765241

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.00489355
2MP0001929_abnormal_gametogenesis5.54482237
3MP0008877_abnormal_DNA_methylation4.13731114
4MP0000678_abnormal_parathyroid_gland3.83203073
5MP0002210_abnormal_sex_determination3.42403017
6MP0002161_abnormal_fertility/fecundity3.29847864
7MP0002249_abnormal_larynx_morphology3.05151453
8MP0002132_abnormal_respiratory_system3.01459214
9MP0001145_abnormal_male_reproductive2.93442335
10MP0005670_abnormal_white_adipose2.83029533
11MP0005451_abnormal_body_composition2.54370220
12MP0000653_abnormal_sex_gland2.53069914
13MP0005360_urolithiasis2.52244246
14MP0002139_abnormal_hepatobiliary_system2.50085421
15MP0002653_abnormal_ependyma_morphology2.38251650
16MP0000003_abnormal_adipose_tissue2.20066574
17MP0003705_abnormal_hypodermis_morpholog2.15293579
18MP0005410_abnormal_fertilization16.3999445
19MP0000013_abnormal_adipose_tissue1.84019119
20MP0003646_muscle_fatigue1.66932607
21MP0005365_abnormal_bile_salt1.65264457
22MP0005409_darkened_coat_color1.63268042
23MP0003172_abnormal_lysosome_physiology1.61193763
24MP0005623_abnormal_meninges_morphology1.60418765
25MP0002160_abnormal_reproductive_system1.56802746
26MP0002822_catalepsy1.43523060
27MP0005503_abnormal_tendon_morphology1.41578885
28MP0001666_abnormal_nutrient_absorption1.39548797
29MP0009384_cardiac_valve_regurgitation1.38474278
30MP0004233_abnormal_muscle_weight1.35771343
31MP0010329_abnormal_lipoprotein_level1.32197292
32MP0000566_synostosis1.30308531
33MP0002138_abnormal_hepatobiliary_system1.30064034
34MP0005083_abnormal_biliary_tract1.27826058
35MP0000467_abnormal_esophagus_morphology1.20692757
36MP0001765_abnormal_ion_homeostasis1.13065500
37MP0002282_abnormal_trachea_morphology1.12955765
38MP0003718_maternal_effect1.10573725
39MP0001873_stomach_inflammation1.09045500
40MP0000681_abnormal_thyroid_gland1.08666043
41MP0008058_abnormal_DNA_repair1.05916807
42MP0005310_abnormal_salivary_gland1.04058640
43MP0009053_abnormal_anal_canal1.01645947
44MP0005085_abnormal_gallbladder_physiolo0.98381757
45MP0002933_joint_inflammation0.97826967
46MP0005058_abnormal_lysosome_morphology0.92306928
47MP0000609_abnormal_liver_physiology0.89362881
48MP0004510_myositis0.86829960
49MP0002254_reproductive_system_inflammat0.86614345
50MP0003091_abnormal_cell_migration0.81767070
51MP0008995_early_reproductive_senescence0.81723175
52MP0005076_abnormal_cell_differentiation0.80436226
53MP0002234_abnormal_pharynx_morphology0.76563727
54MP0009840_abnormal_foam_cell0.75920517
55MP0002970_abnormal_white_adipose0.75463915
56MP0005377_hearing/vestibular/ear_phenot0.75159439
57MP0003878_abnormal_ear_physiology0.75159439
58MP0003115_abnormal_respiratory_system0.74574293
59MP0005535_abnormal_body_temperature0.73664506
60MP0005389_reproductive_system_phenotype0.73616484
61MP0005647_abnormal_sex_gland0.73372873
62MP0005332_abnormal_amino_acid0.71789714
63MP0001984_abnormal_olfaction0.71577500
64MP0004264_abnormal_extraembryonic_tissu0.69805222
65MP0005248_abnormal_Harderian_gland0.69372521
66MP0005395_other_phenotype0.68851133
67MP0003329_amyloid_beta_deposits0.67533768
68MP0000249_abnormal_blood_vessel0.67397971
69MP0003279_aneurysm0.65649426
70MP0005636_abnormal_mineral_homeostasis0.65073533
71MP0009278_abnormal_bone_marrow0.64457610
72MP0002118_abnormal_lipid_homeostasis0.64025165
73MP0009046_muscle_twitch0.63999090
74MP0003111_abnormal_nucleus_morphology0.63241787
75MP0005379_endocrine/exocrine_gland_phen0.62509104
76MP0001545_abnormal_hematopoietic_system0.61728083
77MP0005397_hematopoietic_system_phenotyp0.61728083
78MP0008961_abnormal_basal_metabolism0.60608680
79MP0010094_abnormal_chromosome_stability0.60569472
80MP0000026_abnormal_inner_ear0.59810737
81MP0001293_anophthalmia0.59771797
82MP0003453_abnormal_keratinocyte_physiol0.59408467
83MP0002127_abnormal_cardiovascular_syste0.59346284
84MP0005666_abnormal_adipose_tissue0.58852795
85MP0002269_muscular_atrophy0.58791747
86MP0004381_abnormal_hair_follicle0.58689589
87MP0000470_abnormal_stomach_morphology0.57879089
88MP0001764_abnormal_homeostasis0.57280241
89MP0006036_abnormal_mitochondrial_physio0.56583347
90MP0008875_abnormal_xenobiotic_pharmacok0.56191665
91MP0009643_abnormal_urine_homeostasis0.55360833
92MP0003950_abnormal_plasma_membrane0.54951544
93MP0002108_abnormal_muscle_morphology0.54464465
94MP0001730_embryonic_growth_arrest0.53765459
95MP0002932_abnormal_joint_morphology0.53561526
96MP0003699_abnormal_female_reproductive0.51848056
97MP0000358_abnormal_cell_content/0.51484998
98MP0000751_myopathy0.51234790
99MP0003786_premature_aging0.50872779
100MP0008874_decreased_physiological_sensi0.49931817
101MP0004036_abnormal_muscle_relaxation0.49764418
102MP0004133_heterotaxia0.49136310
103MP0003011_delayed_dark_adaptation0.48914892
104MP0005408_hypopigmentation0.48398378
105MP0002796_impaired_skin_barrier0.47007347
106MP0005595_abnormal_vascular_smooth0.46938771
107MP0001270_distended_abdomen0.46613435
108MP0001324_abnormal_eye_pigmentation0.46160558
109MP0001614_abnormal_blood_vessel0.45724104
110MP0001963_abnormal_hearing_physiology0.45651873
111MP0000598_abnormal_liver_morphology0.45382877
112MP0002735_abnormal_chemical_nociception0.45111806
113MP0008007_abnormal_cellular_replicative0.42056969
114MP0009697_abnormal_copulation0.41935297
115MP0000371_diluted_coat_color0.41092789
116MP0003436_decreased_susceptibility_to0.41009079
117MP0000163_abnormal_cartilage_morphology0.38548593
118MP0000534_abnormal_ureter_morphology0.37935659
119MP0008057_abnormal_DNA_replication0.36549128
120MP0001348_abnormal_lacrimal_gland0.35371203
121MP0001849_ear_inflammation0.34474479
122MP0004145_abnormal_muscle_electrophysio0.33282711
123MP0009672_abnormal_birth_weight0.33247941
124MP0003077_abnormal_cell_cycle0.32800062
125MP0009115_abnormal_fat_cell0.30167841
126MP0000313_abnormal_cell_death0.30151957
127MP0000920_abnormal_myelination0.28255125
128MP0005253_abnormal_eye_physiology0.28187263
129MP0001727_abnormal_embryo_implantation0.28113172
130MP0005391_vision/eye_phenotype0.27697739
131MP0003861_abnormal_nervous_system0.27234624
132MP0002102_abnormal_ear_morphology0.26940440
133MP0002084_abnormal_developmental_patter0.26741173
134MP0001119_abnormal_female_reproductive0.26722422
135MP0002928_abnormal_bile_duct0.26381460
136MP0000604_amyloidosis0.26349804
137MP0002736_abnormal_nociception_after0.26125436
138MP0002873_normal_phenotype0.25645471
139MP0002169_no_abnormal_phenotype0.25556662
140MP0004808_abnormal_hematopoietic_stem0.25013625
141MP0004019_abnormal_vitamin_homeostasis0.24469594
142MP0004811_abnormal_neuron_physiology0.24151984
143MP0003631_nervous_system_phenotype0.23998536
144MP0001697_abnormal_embryo_size0.23882767
145MP0003879_abnormal_hair_cell0.23747768
146MP0002080_prenatal_lethality0.23637802
147MP0004742_abnormal_vestibular_system0.23613241
148MP0001672_abnormal_embryogenesis/_devel0.23279025
149MP0005380_embryogenesis_phenotype0.23279025
150MP0004957_abnormal_blastocyst_morpholog0.23165942
151MP0003806_abnormal_nucleotide_metabolis0.22110718
152MP0003633_abnormal_nervous_system0.21760863
153MP0003942_abnormal_urinary_system0.21167597
154MP0005551_abnormal_eye_electrophysiolog0.21146501
155MP0002152_abnormal_brain_morphology0.20561511
156MP0002092_abnormal_eye_morphology0.19913644
157MP0003693_abnormal_embryo_hatching0.19360722
158MP0005319_abnormal_enzyme/_coenzyme0.18706288
159MP0003948_abnormal_gas_homeostasis0.18488645
160MP0005375_adipose_tissue_phenotype0.18202625
161MP0002229_neurodegeneration0.17732824
162MP0009703_decreased_birth_body0.17482351
163MP0008770_decreased_survivor_rate0.17304593
164MP0003984_embryonic_growth_retardation0.17233858
165MP0002295_abnormal_pulmonary_circulatio0.16979919
166MP0002971_abnormal_brown_adipose0.16931307
167MP0003632_abnormal_nervous_system0.16526313
168MP0000001_mammalian_phenotype0.16386612
169MP0006035_abnormal_mitochondrial_morpho0.16198506

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.17068462
2Abnormal respiratory epithelium morphology (HP:0012253)8.96206734
3Abnormal respiratory motile cilium morphology (HP:0005938)8.96206734
4Rhinitis (HP:0012384)7.46527209
5Chronic bronchitis (HP:0004469)7.35333364
6Abnormal ciliary motility (HP:0012262)7.11072213
7Infertility (HP:0000789)6.99084414
8Nasal polyposis (HP:0100582)6.37648246
9Severe visual impairment (HP:0001141)6.31986956
10Abnormality of the nasal mucosa (HP:0000433)5.31859859
11Male infertility (HP:0003251)5.18844493
12Bronchitis (HP:0012387)4.71103064
13Bronchiectasis (HP:0002110)4.45051144
14Nephronophthisis (HP:0000090)4.13066658
15Abnormal spermatogenesis (HP:0008669)4.05828961
16Hypoplastic ischia (HP:0003175)3.82065461
17Colitis (HP:0002583)3.53872339
18Recurrent otitis media (HP:0000403)3.49974173
19Bony spicule pigmentary retinopathy (HP:0007737)3.40343720
20Hyperkalemia (HP:0002153)3.40001600
21Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.38350060
22Hypoalphalipoproteinemia (HP:0003233)3.31321090
23Abnormality of the ischium (HP:0003174)3.24086618
24Recurrent sinusitis (HP:0011108)3.22075593
25Potter facies (HP:0002009)3.18091926
26Facial shape deformation (HP:0011334)3.18091926
27Deep venous thrombosis (HP:0002625)3.13544114
28Enlarged epiphyses (HP:0010580)3.08937520
29Abnormality of the renal medulla (HP:0100957)3.06643408
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.98540454
31Recurrent bronchitis (HP:0002837)2.94949531
32Impulsivity (HP:0100710)2.93874059
33Broad face (HP:0000283)2.91888802
34Attenuation of retinal blood vessels (HP:0007843)2.83733408
35Atelectasis (HP:0100750)2.79971361
36Resting tremor (HP:0002322)2.72393105
37Abnormality of the aortic arch (HP:0012303)2.71693949
38Thin bony cortex (HP:0002753)2.71342877
39Aplasia/Hypoplasia of the earlobes (HP:0009906)2.61951430
40Tubulointerstitial nephritis (HP:0001970)2.61552600
41Reticulocytosis (HP:0001923)2.58284559
42Azoospermia (HP:0000027)2.57849397
43Stridor (HP:0010307)2.56096720
44Renovascular hypertension (HP:0100817)2.55889586
45Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54568596
46Complement deficiency (HP:0004431)2.53154787
47Tubular atrophy (HP:0000092)2.52827196
48Abnormality of midbrain morphology (HP:0002418)2.50211674
49Molar tooth sign on MRI (HP:0002419)2.50211674
50Abnormal gallbladder physiology (HP:0012438)2.49278634
51Cholecystitis (HP:0001082)2.49278634
52Hyperthyroidism (HP:0000836)2.48642839
53Nuclear cataract (HP:0100018)2.48332439
54Widely patent fontanelles and sutures (HP:0004492)2.47678781
55Obstructive sleep apnea (HP:0002870)2.43497588
56Neoplasm of the heart (HP:0100544)2.43029544
57Upper limb amyotrophy (HP:0009129)2.42249682
58Distal upper limb amyotrophy (HP:0007149)2.42249682
59Abnormal rod and cone electroretinograms (HP:0008323)2.41138930
60Tubulointerstitial abnormality (HP:0001969)2.37027778
61Protuberant abdomen (HP:0001538)2.34830973
62Hypertriglyceridemia (HP:0002155)2.34828824
63Hypoparathyroidism (HP:0000829)2.34400615
64Flattened epiphyses (HP:0003071)2.34287963
65Unilateral renal agenesis (HP:0000122)2.32357108
66Seborrheic dermatitis (HP:0001051)2.31571350
67Abnormality of complement system (HP:0005339)2.30581071
68Gonadotropin excess (HP:0000837)2.30450697
69Cervical subluxation (HP:0003308)2.28074547
70Progressive sensorineural hearing impairment (HP:0000408)2.26482463
71Flat capital femoral epiphysis (HP:0003370)2.26253357
72Abnormality of the costochondral junction (HP:0000919)2.23703925
73Hand muscle atrophy (HP:0009130)2.22831852
74Bowel incontinence (HP:0002607)2.20954668
75Abnormality of the femoral head (HP:0003368)2.16896928
76Hypophosphatemic rickets (HP:0004912)2.15001724
77Dyschromatopsia (HP:0007641)2.14736226
78J-shaped sella turcica (HP:0002680)2.13806223
79Postural instability (HP:0002172)2.12387944
80Truncus arteriosus (HP:0001660)2.12241847
81Abnormality of the parathyroid morphology (HP:0011766)2.11088212
82Esophageal varix (HP:0002040)2.10775795
83Hypolipoproteinemia (HP:0010981)2.07292239
84Medial flaring of the eyebrow (HP:0010747)2.04980518
85Epiphyseal dysplasia (HP:0002656)2.04017769
86Hypoplasia of the thymus (HP:0000778)2.03032736
87Abnormality of the epiphysis of the femoral head (HP:0010574)2.01816625
88Nephritis (HP:0000123)2.01666057
89Spastic tetraparesis (HP:0001285)2.01510029
90Tubulointerstitial fibrosis (HP:0005576)2.01355238
91Lymphangioma (HP:0100764)2.01301988
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.3089061
93Dynein arm defect of respiratory motile cilia (HP:0012255)13.2173813
94Absent/shortened dynein arms (HP:0200106)13.2173813
95Abnormal large intestine physiology (HP:0012700)1.99684802
96Glomerulonephritis (HP:0000099)1.99585455
97Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.98790305
98Abnormality of femoral epiphyses (HP:0006499)1.98790305
99Choroideremia (HP:0001139)1.98213842
100Cerebellar dysplasia (HP:0007033)1.97040536
101Focal segmental glomerulosclerosis (HP:0000097)1.94511850
102Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94366410
103Decreased central vision (HP:0007663)1.93796108
104Generalized aminoaciduria (HP:0002909)1.92588765
105Cerebral aneurysm (HP:0004944)1.89110536
106Cone-rod dystrophy (HP:0000548)1.88800498
107Postaxial foot polydactyly (HP:0001830)1.88725910
108Prolonged partial thromboplastin time (HP:0003645)1.88644601
109Systemic lupus erythematosus (HP:0002725)1.88637437
110Amelogenesis imperfecta (HP:0000705)1.87467119
111Gastrointestinal inflammation (HP:0004386)1.85949317
112Cholelithiasis (HP:0001081)1.83271456
113Neurofibrillary tangles (HP:0002185)1.80936658
114Abdominal distention (HP:0003270)1.80924364
115Chronic hepatic failure (HP:0100626)1.80398680
116Hypophosphatemia (HP:0002148)1.80264527
117Heterotopia (HP:0002282)1.79074525
118Hemorrhage of the eye (HP:0011885)1.77759991
119Abnormal drinking behavior (HP:0030082)1.76587794
120Polydipsia (HP:0001959)1.76587794
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76492644
122Decreased electroretinogram (ERG) amplitude (HP:0000654)1.74131917
123Short ribs (HP:0000773)1.71328960
124Double outlet right ventricle (HP:0001719)1.67008669
125Congenital malformation of the right heart (HP:0011723)1.67008669
126Stage 5 chronic kidney disease (HP:0003774)1.65309391
127Abnormality of renal excretion (HP:0011036)1.62154331
128Congenital hepatic fibrosis (HP:0002612)1.60828568
129Easy fatigability (HP:0003388)1.58689826
130Bell-shaped thorax (HP:0001591)1.56768254
131Oculomotor apraxia (HP:0000657)1.48642982
132Type II lissencephaly (HP:0007260)1.48176460
133Cerebral inclusion bodies (HP:0100314)1.47607058
134Facial cleft (HP:0002006)1.44588360
135Deformed sella turcica (HP:0002681)1.42021331
136Exercise-induced myalgia (HP:0003738)1.41620561
137Abnormality of dentin (HP:0010299)1.41604203
138Abnormality of the lower motor neuron (HP:0002366)1.41058719
139Bile duct proliferation (HP:0001408)1.40829930
140Abnormal biliary tract physiology (HP:0012439)1.40829930
141Abnormal urine output (HP:0012590)1.40404973
142Abnormality of the renal cortex (HP:0011035)1.40240036
143Renal dysplasia (HP:0000110)1.40133875
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.39897335
145Absent epiphyses (HP:0010577)1.39897335
146Sensory axonal neuropathy (HP:0003390)1.39278381
147Myoglobinuria (HP:0002913)1.39026802
148Abnormality of permanent molar morphology (HP:0011071)1.36754546
149Abnormality of the dental root (HP:0006486)1.36754546
150Taurodontia (HP:0000679)1.36754546
151Broad distal phalanx of finger (HP:0009836)1.35138420
152Loss of speech (HP:0002371)1.33143048
153Postaxial hand polydactyly (HP:0001162)1.32590198
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.32404421
155Asymmetric septal hypertrophy (HP:0001670)1.30566855
156Aplasia/Hypoplasia of the lens (HP:0008063)1.26617706
157Abnormality of the dental pulp (HP:0006479)1.25351142
158Abnormality of molar morphology (HP:0011070)1.24533693
159Abnormality of molar (HP:0011077)1.24533693
160Short femoral neck (HP:0100864)1.23680415
161Amyotrophic lateral sclerosis (HP:0007354)1.22775240
162Hypercholesterolemia (HP:0003124)1.21343198
163Bundle branch block (HP:0011710)1.20861777
164Cystic liver disease (HP:0006706)1.20737816
165Short nail (HP:0001799)1.19398245
166Fibular hypoplasia (HP:0003038)1.19297236
167Hemiparesis (HP:0001269)1.19295130
168Abnormality of saccadic eye movements (HP:0000570)1.18303547
169Short thorax (HP:0010306)1.18108142
170Microglossia (HP:0000171)1.18096301
171Median cleft lip (HP:0000161)1.15597668
172Polyuria (HP:0000103)1.15576949
173Nephropathy (HP:0000112)1.15524574
174Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.14236015
175Abnormality of the neuromuscular junction (HP:0003398)1.13732083
176Fatigable weakness (HP:0003473)1.13732083

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK18.47763312
2PDK47.49890211
3PDK37.49890211
4TESK16.73860771
5PRKD35.52161499
6PDK24.82248691
7ICK4.76347009
8CDK124.05662449
9DDR24.00407284
10TRIB33.44270259
11MST1R2.74908327
12BRD42.56004780
13SIK12.53492479
14PNCK2.46709048
15PTK2B2.29361521
16WNK42.24775050
17STK392.19416171
18STK381.88169444
19EPHA21.77864815
20MAP3K61.77636412
21ERN11.76022409
22NEK21.69869321
23DYRK1B1.62178884
24RIPK11.59245856
25CDK71.48742173
26PKN21.40818809
27KSR21.30646935
28INSRR1.27692337
29PDK11.19105652
30TESK21.18612677
31RPS6KA21.17208050
32SIK21.15436469
33TNK21.07343495
34NTRK31.02234942
35MAPK150.97576711
36FGFR40.96532677
37IRAK30.96517949
38MAP3K130.95866988
39SMG10.95455660
40TYRO30.93939070
41DYRK30.93695881
42MAP4K20.90687178
43CAMK1D0.87295650
44MET0.85077932
45MAP3K70.79923608
46WNK10.79590426
47BUB10.79233109
48PRKAA20.78765264
49RPS6KC10.77110814
50RPS6KL10.77110814
51PDPK10.76336401
52LATS20.74216956
53EEF2K0.74158070
54TTK0.72350114
55NME10.70673424
56WEE10.69517796
57PASK0.68724763
58BMX0.68618191
59MAP2K20.68270268
60PTK60.66736367
61CHEK20.66729742
62CCNB10.66030663
63MAP3K110.65280889
64CAMK1G0.61867110
65RPS6KA60.61528353
66PAK10.61387471
67MAP2K60.60485170
68MUSK0.59561423
69IRAK10.58087198
70PINK10.57093955
71PDGFRA0.56748534
72STK30.55668183
73RIPK40.48729977
74BLK0.47718764
75AKT30.47482882
76CDK90.46722469
77MAPK10.46617226
78PLK20.45987244
79ERBB20.45675370
80CDC42BPA0.45358395
81MARK20.45247108
82BRSK20.44666397
83MAPK110.44274962
84CHEK10.43733854
85CSK0.42870805
86PRKD20.42139951
87MAP2K30.40572282
88NTRK20.40408532
89MAP3K90.40287086
90MAP3K100.39930000
91ROCK10.38977475
92MAPK100.38657777
93PIK3CG0.36825434
94PAK20.36486642
95IRAK20.35167081
96PAK40.34343324
97CDC70.33651971
98MAPKAPK50.31348519
99ATR0.31242077
100CHUK0.30847246
101KDR0.30077634
102PRKCG0.28632359
103MTOR0.28541630
104CSF1R0.28416734
105ATM0.27906595
106MAPK140.27718494
107PLK40.27560816
108MAP4K10.27516696
109LMTK20.27240674
110BRSK10.26990208
111RET0.26065673
112PKN10.25016377
113STK38L0.22933427
114TBK10.21559883
115PLK10.20870015
116HIPK20.20692751
117PRKCZ0.20149849
118STK100.19607975
119AKT10.18596741
120PRKAA10.17101417
121CDK150.16553854
122JAK30.16389290
123OXSR10.15607785
124CDK11A0.14164443
125NEK60.13910177
126CDK180.12953459
127RPS6KA10.12760088
128CAMKK10.12126631
129CDK190.11876763
130CDK40.11321659
131AURKA0.10049369
132PAK60.09819297
133CSNK2A10.09595983
134CDK20.09436466
135CDK140.09434109
136RPS6KB10.09291316
137GSK3B0.08664244
138MAP3K10.07929921
139PRKCQ0.07774258
140PRKG20.05888426
141DAPK30.05596585
142MARK30.05490849
143CSNK2A20.05148431
144MAP3K80.05138883
145CDK10.04789672
146CDK60.04368395
147ILK0.02813949
148PRKCD0.02186943
149PRKG10.01976468
150PIM10.01562344
151CAMK2A0.01437794
152STK110.01091092
153MAPK80.01011482
154CAMK10.00861239
155EIF2AK10.00807719
156BRAF0.00739388
157MAP3K20.00582299
158PRKACG0.00467486
159STK160.00280726
160CSNK1D-0.0021767

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.59142227
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.51447012
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.48812199
4Vitamin B6 metabolism_Homo sapiens_hsa007504.08331013
5Pyruvate metabolism_Homo sapiens_hsa006203.32140896
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.16907173
7Linoleic acid metabolism_Homo sapiens_hsa005913.11146891
8Arginine biosynthesis_Homo sapiens_hsa002202.73744849
9Basal transcription factors_Homo sapiens_hsa030222.67044554
10Phenylalanine metabolism_Homo sapiens_hsa003602.66049428
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.57814522
12Glucagon signaling pathway_Homo sapiens_hsa049222.50725488
13Propanoate metabolism_Homo sapiens_hsa006402.50237330
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42661843
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.32261137
16Carbohydrate digestion and absorption_Homo sapiens_hsa049732.19596421
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.06849580
18Selenocompound metabolism_Homo sapiens_hsa004501.92070542
19Pentose phosphate pathway_Homo sapiens_hsa000301.90212492
20Glycerophospholipid metabolism_Homo sapiens_hsa005641.85864712
21Glycerolipid metabolism_Homo sapiens_hsa005611.83959482
22Other glycan degradation_Homo sapiens_hsa005111.83499119
23Complement and coagulation cascades_Homo sapiens_hsa046101.82217287
24Fructose and mannose metabolism_Homo sapiens_hsa000511.77282459
25PPAR signaling pathway_Homo sapiens_hsa033201.77052808
26Oocyte meiosis_Homo sapiens_hsa041141.75448646
27Butanoate metabolism_Homo sapiens_hsa006501.70671415
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.66453027
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65994803
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63114292
31Ether lipid metabolism_Homo sapiens_hsa005651.61733612
32Fat digestion and absorption_Homo sapiens_hsa049751.60552838
33Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59756518
34Tyrosine metabolism_Homo sapiens_hsa003501.56393759
35Retinol metabolism_Homo sapiens_hsa008301.51120125
36Dorso-ventral axis formation_Homo sapiens_hsa043201.50181220
37Histidine metabolism_Homo sapiens_hsa003401.49929371
38Carbon metabolism_Homo sapiens_hsa012001.49697562
39Fatty acid degradation_Homo sapiens_hsa000711.46880010
40Notch signaling pathway_Homo sapiens_hsa043301.45692044
41Mineral absorption_Homo sapiens_hsa049781.44795952
42Fatty acid metabolism_Homo sapiens_hsa012121.44515809
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.36892505
44Acute myeloid leukemia_Homo sapiens_hsa052211.30986138
45Amphetamine addiction_Homo sapiens_hsa050311.28282867
46RNA transport_Homo sapiens_hsa030131.27489093
47Antigen processing and presentation_Homo sapiens_hsa046121.26665061
48Fanconi anemia pathway_Homo sapiens_hsa034601.26207733
49Arginine and proline metabolism_Homo sapiens_hsa003301.20596376
50mRNA surveillance pathway_Homo sapiens_hsa030151.19514709
51Purine metabolism_Homo sapiens_hsa002301.15481562
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.13943648
53Glutathione metabolism_Homo sapiens_hsa004801.13920125
54Lysine degradation_Homo sapiens_hsa003101.13074984
55Biosynthesis of amino acids_Homo sapiens_hsa012301.11164957
56Olfactory transduction_Homo sapiens_hsa047401.09724636
57Prion diseases_Homo sapiens_hsa050201.09678117
58Cardiac muscle contraction_Homo sapiens_hsa042601.08899032
59Type II diabetes mellitus_Homo sapiens_hsa049301.05304374
60Huntingtons disease_Homo sapiens_hsa050161.02606343
61Glycosaminoglycan degradation_Homo sapiens_hsa005310.97901849
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97721855
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97131480
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96922306
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94886211
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91978873
67Insulin resistance_Homo sapiens_hsa049310.90518254
68Insulin signaling pathway_Homo sapiens_hsa049100.89748108
69Hedgehog signaling pathway_Homo sapiens_hsa043400.87487298
70Caffeine metabolism_Homo sapiens_hsa002320.85696181
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.85227712
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.77860480
73Arachidonic acid metabolism_Homo sapiens_hsa005900.76178939
74Sulfur relay system_Homo sapiens_hsa041220.74556494
75Renin secretion_Homo sapiens_hsa049240.74177699
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73205846
77Pyrimidine metabolism_Homo sapiens_hsa002400.72840751
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72768474
79Chemical carcinogenesis_Homo sapiens_hsa052040.71385578
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.68661711
81Renin-angiotensin system_Homo sapiens_hsa046140.68529193
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68164632
83Chronic myeloid leukemia_Homo sapiens_hsa052200.66614495
84Endocytosis_Homo sapiens_hsa041440.66016989
85Thyroid hormone synthesis_Homo sapiens_hsa049180.63801163
86Estrogen signaling pathway_Homo sapiens_hsa049150.63085573
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62939107
88Long-term potentiation_Homo sapiens_hsa047200.60437492
89mTOR signaling pathway_Homo sapiens_hsa041500.59430968
90Starch and sucrose metabolism_Homo sapiens_hsa005000.59307320
91Bile secretion_Homo sapiens_hsa049760.58882588
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58732127
93Collecting duct acid secretion_Homo sapiens_hsa049660.58386189
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.56438628
95Legionellosis_Homo sapiens_hsa051340.56339131
96Insulin secretion_Homo sapiens_hsa049110.56094645
97Influenza A_Homo sapiens_hsa051640.55918438
98Prolactin signaling pathway_Homo sapiens_hsa049170.55487087
99Systemic lupus erythematosus_Homo sapiens_hsa053220.53820351
100Non-small cell lung cancer_Homo sapiens_hsa052230.52639087
101Bladder cancer_Homo sapiens_hsa052190.52491499
102Taste transduction_Homo sapiens_hsa047420.51886447
103Choline metabolism in cancer_Homo sapiens_hsa052310.50781434
104DNA replication_Homo sapiens_hsa030300.48003581
105B cell receptor signaling pathway_Homo sapiens_hsa046620.46468001
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46285282
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46195467
108RNA degradation_Homo sapiens_hsa030180.45940336
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45491964
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45273978
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43902042
112AMPK signaling pathway_Homo sapiens_hsa041520.43600790
113AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42846578
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42751046
115Pancreatic secretion_Homo sapiens_hsa049720.41734243
116Metabolic pathways_Homo sapiens_hsa011000.41098686
117Spliceosome_Homo sapiens_hsa030400.40763163
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.39519840
119Protein digestion and absorption_Homo sapiens_hsa049740.38210511
120Staphylococcus aureus infection_Homo sapiens_hsa051500.38193809
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37735536
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.37094553
123Vitamin digestion and absorption_Homo sapiens_hsa049770.35065907
124ABC transporters_Homo sapiens_hsa020100.34838455
125Sulfur metabolism_Homo sapiens_hsa009200.34826319
126Cell cycle_Homo sapiens_hsa041100.34450986
127Galactose metabolism_Homo sapiens_hsa000520.33642202
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.33139983
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32781028
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31848814
131MAPK signaling pathway_Homo sapiens_hsa040100.31749964
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30832096
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.30376981
134Focal adhesion_Homo sapiens_hsa045100.29894424
135Viral carcinogenesis_Homo sapiens_hsa052030.29862711
136Calcium signaling pathway_Homo sapiens_hsa040200.29725992
137Autoimmune thyroid disease_Homo sapiens_hsa053200.29323378
138Alcoholism_Homo sapiens_hsa050340.29175507
139Allograft rejection_Homo sapiens_hsa053300.28752675
140Platelet activation_Homo sapiens_hsa046110.28588635
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27271307
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26344836
143Proteasome_Homo sapiens_hsa030500.25604217
144Synaptic vesicle cycle_Homo sapiens_hsa047210.25544391
145Salivary secretion_Homo sapiens_hsa049700.24809918
146Epstein-Barr virus infection_Homo sapiens_hsa051690.24332612
147Inositol phosphate metabolism_Homo sapiens_hsa005620.23251492
148VEGF signaling pathway_Homo sapiens_hsa043700.18876625
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.17280384
150Basal cell carcinoma_Homo sapiens_hsa052170.17060203
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16752167
152Gastric acid secretion_Homo sapiens_hsa049710.15856259
153HIF-1 signaling pathway_Homo sapiens_hsa040660.15313241
154Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.13321309
155Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11948340

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