STRA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1embryonic foregut morphogenesis (GO:0048617)4.81875378
2epithelial cilium movement (GO:0003351)4.62382308
3epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.51648497
4behavioral response to nicotine (GO:0035095)4.42063214
5regulation of transforming growth factor beta2 production (GO:0032909)4.34030535
6vitamin A metabolic process (GO:0006776)4.31695248
7hemidesmosome assembly (GO:0031581)4.25078987
8negative regulation of catenin import into nucleus (GO:0035414)4.12713794
9axonemal dynein complex assembly (GO:0070286)4.12691679
10cilium movement (GO:0003341)4.09365372
11polarized epithelial cell differentiation (GO:0030859)3.83195336
12paraxial mesoderm development (GO:0048339)3.71645479
13hippo signaling (GO:0035329)3.63807514
14cilium or flagellum-dependent cell motility (GO:0001539)3.55296717
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.55179774
16dorsal/ventral axis specification (GO:0009950)3.51568318
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.50603089
18nuclear pore complex assembly (GO:0051292)3.49737170
19enteric nervous system development (GO:0048484)3.46932477
20estrogen biosynthetic process (GO:0006703)3.42554619
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.39977747
22cell proliferation involved in metanephros development (GO:0072203)3.39678786
23establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.36716557
24regulation of non-canonical Wnt signaling pathway (GO:2000050)3.33580792
25axoneme assembly (GO:0035082)3.32779830
26sympathetic nervous system development (GO:0048485)3.32759610
27G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.25586713
28behavioral response to ethanol (GO:0048149)3.25167551
29pre-miRNA processing (GO:0031054)3.24971381
30establishment of tissue polarity (GO:0007164)3.20414206
31establishment of planar polarity (GO:0001736)3.20414206
32regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.17269900
33notochord development (GO:0030903)3.14078958
34* head development (GO:0060322)3.13001777
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.11094560
36positive regulation of dendritic spine morphogenesis (GO:0061003)3.10153024
37regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.07616679
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.06777212
39positive regulation of receptor biosynthetic process (GO:0010870)3.04769120
40renal system development (GO:0072001)3.03988863
41negative regulation of cell fate specification (GO:0009996)3.03140356
42nuclear pore organization (GO:0006999)3.02781001
43diterpenoid biosynthetic process (GO:0016102)3.00915891
44branching involved in salivary gland morphogenesis (GO:0060445)3.00290781
45regulation of cilium movement (GO:0003352)2.99255009
46convergent extension (GO:0060026)2.95679853
47intraciliary transport (GO:0042073)2.95177935
48establishment of apical/basal cell polarity (GO:0035089)2.94745812
49RNA stabilization (GO:0043489)2.93982145
50mRNA stabilization (GO:0048255)2.93982145
51spliceosomal tri-snRNP complex assembly (GO:0000244)2.93326866
52motile cilium assembly (GO:0044458)2.92409549
53nephron tubule morphogenesis (GO:0072078)2.92360822
54nephron epithelium morphogenesis (GO:0072088)2.92360822
55nonmotile primary cilium assembly (GO:0035058)2.92288829
56non-canonical Wnt signaling pathway (GO:0035567)2.89743399
57cilium organization (GO:0044782)2.89341263
58epithelial cell differentiation involved in prostate gland development (GO:0060742)2.89226476
59regulation of hippo signaling (GO:0035330)2.89053028
60positive regulation of epithelial to mesenchymal transition (GO:0010718)2.87365036
61establishment or maintenance of bipolar cell polarity (GO:0061245)2.86072465
62establishment or maintenance of apical/basal cell polarity (GO:0035088)2.86072465
63cilium assembly (GO:0042384)2.85391203
64regulation of sister chromatid cohesion (GO:0007063)2.85259495
65regulation of establishment of planar polarity (GO:0090175)2.84160088
66branching involved in mammary gland duct morphogenesis (GO:0060444)2.83932540
67Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83844356
68proximal/distal pattern formation (GO:0009954)2.82835079
69collecting duct development (GO:0072044)2.81888509
70neuron projection extension involved in neuron projection guidance (GO:1902284)2.81650156
71axon extension involved in axon guidance (GO:0048846)2.81650156
72lateral sprouting from an epithelium (GO:0060601)2.79661958
73mesenchymal cell proliferation (GO:0010463)2.79151998
74regulation of cardioblast proliferation (GO:0003264)2.78330317
75regulation of secondary heart field cardioblast proliferation (GO:0003266)2.78330317
76body morphogenesis (GO:0010171)2.78294323
77left/right pattern formation (GO:0060972)2.77380512
78ganglion development (GO:0061548)2.76875528
79renal filtration (GO:0097205)2.76700597
80heterochromatin organization (GO:0070828)2.76362969
81cilium morphogenesis (GO:0060271)2.75999446
82hepatocyte apoptotic process (GO:0097284)2.75531055
83glial cell proliferation (GO:0014009)2.73853085
84cardiovascular system development (GO:0072358)2.73488547
85epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72928437
86bone morphogenesis (GO:0060349)2.71082491
87chondrocyte proliferation (GO:0035988)2.70837503
88molting cycle (GO:0042303)2.70194551
89hair cycle (GO:0042633)2.70194551
90L-fucose catabolic process (GO:0042355)2.69653109
91fucose catabolic process (GO:0019317)2.69653109
92L-fucose metabolic process (GO:0042354)2.69653109
93lung-associated mesenchyme development (GO:0060484)2.68357375
94embryonic skeletal joint morphogenesis (GO:0060272)2.66265111
95protein polyglutamylation (GO:0018095)2.65392999
96response to UV-C (GO:0010225)2.65342340
97cell-substrate junction assembly (GO:0007044)2.64577988
98mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.64289668
99somite development (GO:0061053)2.64028424
100desmosome organization (GO:0002934)2.61415310
101cell proliferation involved in kidney development (GO:0072111)2.61256042
102membrane repolarization during action potential (GO:0086011)2.61138129
103pore complex assembly (GO:0046931)2.60386266
104catecholamine transport (GO:0051937)2.59908003
105adherens junction assembly (GO:0034333)2.58858273
106vascular endothelial growth factor signaling pathway (GO:0038084)2.58744748
107positive regulation of dendrite morphogenesis (GO:0050775)2.58005380
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.57383477
109negative regulation of axon extension involved in axon guidance (GO:0048843)2.55222302
110regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.55155329
111cell surface receptor signaling pathway involved in heart development (GO:0061311)2.55105367
112tongue development (GO:0043586)2.55041837
113positive regulation of hormone biosynthetic process (GO:0046886)2.55004330
114negative regulation of epidermis development (GO:0045683)2.54232101
115mesodermal cell differentiation (GO:0048333)2.53305225
116hindbrain development (GO:0030902)2.53261100
117gastrulation with mouth forming second (GO:0001702)2.52658172
118positive regulation of BMP signaling pathway (GO:0030513)2.52396107
119anterior/posterior axis specification, embryo (GO:0008595)2.50476342
120embryonic forelimb morphogenesis (GO:0035115)2.49768686
121negative regulation of vascular permeability (GO:0043116)2.49425921
122regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.48203940
123regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.48139645
124negative regulation of cartilage development (GO:0061037)2.46466438
125preassembly of GPI anchor in ER membrane (GO:0016254)2.45859182
126hindlimb morphogenesis (GO:0035137)2.44893676
127male genitalia development (GO:0030539)2.43922890
128bone trabecula formation (GO:0060346)2.43628741
129establishment or maintenance of monopolar cell polarity (GO:0061339)2.43131972
130establishment of monopolar cell polarity (GO:0061162)2.43131972
131positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.42715191
132negative regulation of chondrocyte differentiation (GO:0032331)2.42596562
133cornea development in camera-type eye (GO:0061303)2.42252962
134regulation of heart morphogenesis (GO:2000826)2.42154212
135regulation of catenin import into nucleus (GO:0035412)2.41527810
136regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.40736583
137coronary vasculature morphogenesis (GO:0060977)2.39745833
138lens fiber cell development (GO:0070307)2.39052400
139regulation of mesenchymal cell apoptotic process (GO:2001053)2.38720943
140histone H2A acetylation (GO:0043968)2.37705060
141cochlea morphogenesis (GO:0090103)2.37193902
142positive regulation of gastrulation (GO:2000543)2.35344171
143response to pheromone (GO:0019236)2.32822110
144urogenital system development (GO:0001655)2.32076638
145cartilage morphogenesis (GO:0060536)2.31640205
146cell proliferation in forebrain (GO:0021846)2.30048245
147embryonic digit morphogenesis (GO:0042733)2.29794569
148neural crest cell migration (GO:0001755)2.28883978
149detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.28349210
150lateral ventricle development (GO:0021670)2.27026652
151smoothened signaling pathway (GO:0007224)2.26327906
152retinal ganglion cell axon guidance (GO:0031290)2.24713549
153microtubule bundle formation (GO:0001578)2.24244514
154snRNA processing (GO:0016180)2.23382822
155outer ear morphogenesis (GO:0042473)2.22920011
156detection of light stimulus involved in sensory perception (GO:0050962)2.21093141
157detection of light stimulus involved in visual perception (GO:0050908)2.21093141
158calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.20699102
159spinal cord motor neuron differentiation (GO:0021522)2.19015849
160embryonic epithelial tube formation (GO:0001838)2.18871442
161cellular component assembly involved in morphogenesis (GO:0010927)2.18100185
162positive regulation of smoothened signaling pathway (GO:0045880)2.17976682
163protein localization to synapse (GO:0035418)2.16393941
164negative regulation of axon guidance (GO:1902668)2.14256951
165seminiferous tubule development (GO:0072520)2.12676230
166kidney morphogenesis (GO:0060993)2.11484199
167negative regulation of transcription regulatory region DNA binding (GO:2000678)2.11184640
168epithelial tube formation (GO:0072175)2.09399287
169negative chemotaxis (GO:0050919)2.04323972
170piRNA metabolic process (GO:0034587)2.04023998
171determination of left/right symmetry (GO:0007368)2.03908962
172dopaminergic neuron differentiation (GO:0071542)2.03493885
173embryonic hindlimb morphogenesis (GO:0035116)2.02813885
174regulation of gene silencing by RNA (GO:0060966)2.01675493
175regulation of posttranscriptional gene silencing (GO:0060147)2.01675493
176regulation of gene silencing by miRNA (GO:0060964)2.01675493
177dendritic spine morphogenesis (GO:0060997)2.01660736

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.54909548
2ZNF274_21170338_ChIP-Seq_K562_Hela3.23965613
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19292658
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.89727902
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.89260667
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.66335884
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55340313
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.52107315
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.39022630
10GBX2_23144817_ChIP-Seq_PC3_Human2.27635512
11ESR1_20079471_ChIP-ChIP_T-47D_Human2.26074813
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23189740
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.21381660
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.18976777
15* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.17349501
16ZFP281_27345836_Chip-Seq_ESCs_Mouse2.16687105
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15857605
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.07009331
19CDX2_20551321_ChIP-Seq_CACO-2_Human2.06363426
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02865864
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02535370
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.00005761
23E2F7_22180533_ChIP-Seq_HELA_Human1.98011181
24VDR_22108803_ChIP-Seq_LS180_Human1.97727011
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91466366
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88087093
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.86643355
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.85177375
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.84754776
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77763728
31KDM2B_26808549_Chip-Seq_K562_Human1.76291311
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.73877865
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.73877865
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.73877865
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.71314942
36BMI1_23680149_ChIP-Seq_NPCS_Mouse1.70832234
37IRF1_19129219_ChIP-ChIP_H3396_Human1.70567411
38RING1B_27294783_Chip-Seq_NPCs_Mouse1.70312961
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.69343223
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68282488
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65564707
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.65370076
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64596511
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61714867
45AR_21909140_ChIP-Seq_LNCAP_Human1.61713925
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61340982
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.60979525
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.60534954
49CLOCK_20551151_ChIP-Seq_293T_Human1.59700679
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58467567
51* ELK3_25401928_ChIP-Seq_HUVEC_Human1.57740286
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.57230002
53SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.56261468
54SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.55922485
55ISL1_27105846_Chip-Seq_CPCs_Mouse1.55242245
56ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54665169
57RACK7_27058665_Chip-Seq_MCF-7_Human1.54623916
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53512620
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53444458
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53224273
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.53057548
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49465690
63GABP_17652178_ChIP-ChIP_JURKAT_Human1.49100444
64ESR1_21235772_ChIP-Seq_MCF-7_Human1.49009580
65* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.46992607
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46386358
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44263568
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43436050
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43436050
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40212416
71MYC_18940864_ChIP-ChIP_HL60_Human1.40197338
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39819266
73TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37884734
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37554479
75* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37396825
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35947911
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33663637
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.33497454
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31338084
80* ATF3_27146783_Chip-Seq_COLON_Human1.30222009
81PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29324629
82LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29002178
83MYC_22102868_ChIP-Seq_BL_Human1.27795279
84TCF7_22412390_ChIP-Seq_EML_Mouse1.27131902
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27049636
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.26770928
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.25785293
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25731906
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25731906
90KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25626422
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24648371
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.24550876
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.24444668
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24043323
95TP53_22127205_ChIP-Seq_IMR90_Human1.24036785
96IGF1R_20145208_ChIP-Seq_DFB_Human1.23409954
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23367092
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22218148
99KDM2B_26808549_Chip-Seq_DND41_Human1.19407869
100* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19363278
101* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.19068577
102* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.19028165
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18640205
104GATA6_25053715_ChIP-Seq_YYC3_Human1.18619356
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18234471
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18234471
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.17948967
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.17621398
109KLF5_25053715_ChIP-Seq_YYC3_Human1.17617385
110EWS_26573619_Chip-Seq_HEK293_Human1.17524546
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17414390
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.17231107
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16539534
114LXR_22292898_ChIP-Seq_THP-1_Human1.14557432
115FUS_26573619_Chip-Seq_HEK293_Human1.14329941
116TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12652080
117P300_19829295_ChIP-Seq_ESCs_Human1.12599365
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12262612
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.11157781
120RNF2_27304074_Chip-Seq_ESCs_Mouse1.10328003
121KDM2B_26808549_Chip-Seq_JURKAT_Human1.09905215
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09672953
123POU5F1_16518401_ChIP-PET_MESCs_Mouse1.09357739
124IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08301035
125EED_16625203_ChIP-ChIP_MESCs_Mouse1.07977323
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07862169
127RNF2_27304074_Chip-Seq_NSC_Mouse1.07316063
128ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06432364
129EZH2_27304074_Chip-Seq_ESCs_Mouse1.06411313
130SMAD4_21741376_ChIP-Seq_EPCs_Human1.06000792
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05805334
132RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05364733
133ELK4_26923725_Chip-Seq_MESODERM_Mouse1.05358788
134SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05172094
135UBF1/2_26484160_Chip-Seq_HMECs_Human1.05027137
136HOXB7_26014856_ChIP-Seq_BT474_Human1.03677751
137RING1B_27294783_Chip-Seq_ESCs_Mouse1.02636976
138* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02620228
139KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01516992
140PKCTHETA_26484144_Chip-Seq_BREAST_Human1.00804870
141E2F1_17053090_ChIP-ChIP_MCF-7_Human1.00076123
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.99995184
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99341185
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99338345
145JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99220967
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.98927604
147* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98590689
148GATA3_21878914_ChIP-Seq_MCF-7_Human0.98224849
149STAT3_23295773_ChIP-Seq_U87_Human0.97648301
150SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96379958
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95500261
152DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95052308
153STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95018058
154CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.94955415
155* SOX2_16153702_ChIP-ChIP_HESCs_Human0.94596695
156ER_23166858_ChIP-Seq_MCF-7_Human0.94474145
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94000290
158SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.93758931
159TP53_22573176_ChIP-Seq_HFKS_Human0.93665058
160DROSHA_22980978_ChIP-Seq_HELA_Human0.93342282
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93242518
162PIAS1_25552417_ChIP-Seq_VCAP_Human0.93230907
163CTCF_27219007_Chip-Seq_Bcells_Human0.93176210
164CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.92034252
165REST_21632747_ChIP-Seq_MESCs_Mouse0.91983507
166AR_25329375_ChIP-Seq_VCAP_Human0.91611413
167FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90771855
168FOXA1_25329375_ChIP-Seq_VCAP_Human0.90771855
169SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.90128619
170SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89481123
171MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88795347
172TCF4_23295773_ChIP-Seq_U87_Human0.88256010
173AHR_22903824_ChIP-Seq_MCF-7_Human0.87685599
174CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87607503
175PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87209249
176SMAD4_21799915_ChIP-Seq_A2780_Human0.86897144
177SMAD4_21741376_ChIP-Seq_HESCs_Human0.86084302
178MYC_19829295_ChIP-Seq_ESCs_Human0.86057022
179FLI1_27457419_Chip-Seq_LIVER_Mouse0.85973831
180* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85752846
181EZH2_22144423_ChIP-Seq_EOC_Human0.85726878
182TP53_16413492_ChIP-PET_HCT116_Human0.84972002
183AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84545904
184NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84476276
185RUNX2_22187159_ChIP-Seq_PCA_Human0.83849837
186* AR_20517297_ChIP-Seq_VCAP_Human0.83365849
187ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82794653

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat3.79769519
2MP0000537_abnormal_urethra_morphology3.65525720
3MP0003011_delayed_dark_adaptation3.09670439
4MP0002822_catalepsy2.74964940
5MP0003705_abnormal_hypodermis_morpholog2.73206655
6MP0004272_abnormal_basement_membrane2.67817613
7MP0010030_abnormal_orbit_morphology2.46511270
8MP0009053_abnormal_anal_canal2.41483698
9MP0003122_maternal_imprinting2.38437336
10MP0005623_abnormal_meninges_morphology2.37669950
11MP0005076_abnormal_cell_differentiation2.23073316
12MP0010234_abnormal_vibrissa_follicle2.18363927
13MP0002751_abnormal_autonomic_nervous2.18268289
14MP0004264_abnormal_extraembryonic_tissu2.17925808
15MP0008875_abnormal_xenobiotic_pharmacok2.12929178
16MP0003123_paternal_imprinting2.09122158
17MP0002249_abnormal_larynx_morphology2.08365023
18MP0010678_abnormal_skin_adnexa2.02768690
19MP0002938_white_spotting2.01845732
20MP0000383_abnormal_hair_follicle1.98898357
21MP0005248_abnormal_Harderian_gland1.95646400
22MP0002098_abnormal_vibrissa_morphology1.93683818
23MP0004133_heterotaxia1.88109781
24MP0000049_abnormal_middle_ear1.83473808
25MP0010352_gastrointestinal_tract_polyps1.81856688
26MP0003942_abnormal_urinary_system1.80554841
27MP0006292_abnormal_olfactory_placode1.80063811
28MP0005394_taste/olfaction_phenotype1.79911294
29MP0005499_abnormal_olfactory_system1.79911294
30MP0001346_abnormal_lacrimal_gland1.79398507
31MP0003115_abnormal_respiratory_system1.71019084
32MP0004858_abnormal_nervous_system1.69407126
33MP0001849_ear_inflammation1.69063028
34MP0000534_abnormal_ureter_morphology1.68565158
35MP0002653_abnormal_ependyma_morphology1.67627616
36MP0003937_abnormal_limbs/digits/tail_de1.67576735
37MP0005503_abnormal_tendon_morphology1.67472338
38MP0008789_abnormal_olfactory_epithelium1.66495270
39MP0005551_abnormal_eye_electrophysiolog1.63811905
40MP0006072_abnormal_retinal_apoptosis1.63331925
41MP0002697_abnormal_eye_size1.62641425
42MP0001984_abnormal_olfaction1.61611780
43MP0003121_genomic_imprinting1.59339933
44MP0003935_abnormal_craniofacial_develop1.58040529
45MP0003385_abnormal_body_wall1.56425483
46MP0000566_synostosis1.56033001
47MP0003136_yellow_coat_color1.54140215
48MP0000733_abnormal_muscle_development1.53254510
49MP0005253_abnormal_eye_physiology1.52520293
50MP0003119_abnormal_digestive_system1.52235309
51MP0003938_abnormal_ear_development1.51580198
52MP0003890_abnormal_embryonic-extraembry1.49697893
53MP0006276_abnormal_autonomic_nervous1.48183023
54MP0002638_abnormal_pupillary_reflex1.44691889
55MP0002837_dystrophic_cardiac_calcinosis1.42685344
56MP0003941_abnormal_skin_development1.41625564
57MP0005367_renal/urinary_system_phenotyp1.41383339
58MP0000516_abnormal_urinary_system1.41383339
59MP0004197_abnormal_fetal_growth/weight/1.40935136
60MP0000647_abnormal_sebaceous_gland1.40517978
61MP0000428_abnormal_craniofacial_morphol1.40083749
62MP0003755_abnormal_palate_morphology1.37059973
63MP0003315_abnormal_perineum_morphology1.36082177
64MP0006054_spinal_hemorrhage1.35418253
65MP0000762_abnormal_tongue_morphology1.35124289
66MP0008877_abnormal_DNA_methylation1.34784859
67MP0002932_abnormal_joint_morphology1.31521296
68MP0005187_abnormal_penis_morphology1.31425769
69MP0002092_abnormal_eye_morphology1.28208382
70MP0002084_abnormal_developmental_patter1.27622629
71MP0002233_abnormal_nose_morphology1.27398246
72MP0001348_abnormal_lacrimal_gland1.25913493
73MP0000538_abnormal_urinary_bladder1.24557587
74MP0003878_abnormal_ear_physiology1.22276522
75MP0005377_hearing/vestibular/ear_phenot1.22276522
76MP0002234_abnormal_pharynx_morphology1.19564496
77MP0002116_abnormal_craniofacial_bone1.17580964
78MP0000432_abnormal_head_morphology1.17079305
79MP0004019_abnormal_vitamin_homeostasis1.15339291
80MP0002086_abnormal_extraembryonic_tissu1.14891771
81MP0002085_abnormal_embryonic_tissue1.14875806
82MP0003453_abnormal_keratinocyte_physiol1.13648514
83MP0005257_abnormal_intraocular_pressure1.12728614
84MP0005391_vision/eye_phenotype1.10816334
85MP0000778_abnormal_nervous_system1.10376744
86MP0005195_abnormal_posterior_eye1.09198242
87MP0002925_abnormal_cardiovascular_devel1.08189476
88MP0001915_intracranial_hemorrhage1.08116655
89MP0002184_abnormal_innervation1.06942740
90MP0003567_abnormal_fetal_cardiomyocyte1.06659887
91MP0001324_abnormal_eye_pigmentation1.05433106
92MP0000377_abnormal_hair_follicle1.05129918
93MP0001873_stomach_inflammation1.04427699
94MP0002282_abnormal_trachea_morphology1.03236288
95MP0001286_abnormal_eye_development1.03101657
96MP0001529_abnormal_vocalization1.02859931
97MP0002752_abnormal_somatic_nervous1.02113367
98MP0005167_abnormal_blood-brain_barrier1.01421605
99MP0002111_abnormal_tail_morphology1.01142660
100MP0000631_abnormal_neuroendocrine_gland1.00925571
101MP0002102_abnormal_ear_morphology1.00914838
102MP0001672_abnormal_embryogenesis/_devel1.00740336
103MP0005380_embryogenesis_phenotype1.00740336
104MP0002088_abnormal_embryonic_growth/wei1.00504069
105MP0002163_abnormal_gland_morphology1.00346465
106MP0001986_abnormal_taste_sensitivity0.99608357
107MP0000372_irregular_coat_pigmentation0.99464762
108MP0003984_embryonic_growth_retardation0.99036631
109MP0002557_abnormal_social/conspecific_i0.98254355
110MP0009250_abnormal_appendicular_skeleto0.97771552
111MP0000613_abnormal_salivary_gland0.96899056
112MP0002109_abnormal_limb_morphology0.96863567
113MP0003787_abnormal_imprinting0.96332039
114MP0001299_abnormal_eye_distance/0.95656738
115MP0003861_abnormal_nervous_system0.94887855
116MP0009384_cardiac_valve_regurgitation0.94664928
117MP0002909_abnormal_adrenal_gland0.94009640
118MP0000467_abnormal_esophagus_morphology0.93991226
119MP0006138_congestive_heart_failure0.93980210
120MP0008872_abnormal_physiological_respon0.92212442
121MP0002160_abnormal_reproductive_system0.91967652
122MP0002796_impaired_skin_barrier0.91958253
123MP0000026_abnormal_inner_ear0.91406326
124MP0000579_abnormal_nail_morphology0.91051631
125MP0003566_abnormal_cell_adhesion0.90473409
126MP0010386_abnormal_urinary_bladder0.90267119
127MP0004147_increased_porphyrin_level0.89982683
128MP0001697_abnormal_embryo_size0.89598926
129MP0005171_absent_coat_pigmentation0.87858436
130MP0003091_abnormal_cell_migration0.87802793
131MP0000462_abnormal_digestive_system0.87784999
132MP0001293_anophthalmia0.87001999
133MP0000427_abnormal_hair_cycle0.86388410
134MP0003936_abnormal_reproductive_system0.85988296
135MP0003693_abnormal_embryo_hatching0.85122331
136MP0001270_distended_abdomen0.84920255
137MP0005275_abnormal_skin_tensile0.84778184
138MP0005083_abnormal_biliary_tract0.83779463
139MP0002177_abnormal_outer_ear0.83586150
140MP0005508_abnormal_skeleton_morphology0.83533025
141MP0008775_abnormal_heart_ventricle0.82611974
142MP0005389_reproductive_system_phenotype0.81067900
143MP0000678_abnormal_parathyroid_gland0.80005312
144MP0003283_abnormal_digestive_organ0.79310346
145MP0005501_abnormal_skin_physiology0.79122062
146MP0002210_abnormal_sex_determination0.77680745
147MP0005670_abnormal_white_adipose0.76924057
148MP0005075_abnormal_melanosome_morpholog0.76053914
149MP0001968_abnormal_touch/_nociception0.75716655

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic fibrosis (HP:0100732)3.89568819
2Molar tooth sign on MRI (HP:0002419)3.73424819
3Abnormality of midbrain morphology (HP:0002418)3.73424819
4True hermaphroditism (HP:0010459)3.71832770
5Renal duplication (HP:0000075)3.65963927
6Pancreatic cysts (HP:0001737)3.62530109
7Abnormal respiratory motile cilium morphology (HP:0005938)3.59586488
8Abnormal respiratory epithelium morphology (HP:0012253)3.59586488
9Occipital encephalocele (HP:0002085)3.57383530
10Nephronophthisis (HP:0000090)3.47146061
11Onycholysis (HP:0001806)3.44565797
12Right ventricular cardiomyopathy (HP:0011663)3.27347621
13Cystic liver disease (HP:0006706)3.11129628
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.07324012
15Short 4th metacarpal (HP:0010044)3.07324012
16Absent/shortened dynein arms (HP:0200106)2.95776500
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.95776500
18Tubular atrophy (HP:0000092)2.94153842
19Milia (HP:0001056)2.94131851
20Abnormal ciliary motility (HP:0012262)2.89927757
21Abnormality of the renal medulla (HP:0100957)2.87941190
22Woolly hair (HP:0002224)2.87209587
23Abnormality of the distal phalanx of the thumb (HP:0009617)2.79998936
24Congenital stationary night blindness (HP:0007642)2.76007570
25Fragile nails (HP:0001808)2.73695318
26Hepatoblastoma (HP:0002884)2.72118359
27Abnormality of the 4th metacarpal (HP:0010012)2.70816153
28Abnormal respiratory motile cilium physiology (HP:0012261)2.69884521
29Medial flaring of the eyebrow (HP:0010747)2.67693366
30Renovascular hypertension (HP:0100817)2.67113692
31Hyperacusis (HP:0010780)2.66618491
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.65252668
33Shallow orbits (HP:0000586)2.64357672
34* Bilateral microphthalmos (HP:0007633)2.61502810
35Rhinitis (HP:0012384)2.59144040
36Rectal prolapse (HP:0002035)2.58020417
37Postaxial foot polydactyly (HP:0001830)2.51314873
38Selective tooth agenesis (HP:0001592)2.48192945
39Type II lissencephaly (HP:0007260)2.47223467
40Broad thumb (HP:0011304)2.45428736
41Uterine leiomyosarcoma (HP:0002891)2.43983674
42Leiomyosarcoma (HP:0100243)2.43983674
43Congenital primary aphakia (HP:0007707)2.43278610
44Anencephaly (HP:0002323)2.42635760
45Hypotrichosis (HP:0001006)2.41674567
46Atrophic scars (HP:0001075)2.39622219
47Deviation of the thumb (HP:0009603)2.39413419
48Overriding aorta (HP:0002623)2.39269638
49Pendular nystagmus (HP:0012043)2.38591393
50Absent epiphyses (HP:0010577)2.38281822
51Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.38281822
52Vaginal atresia (HP:0000148)2.37532173
53Trigonocephaly (HP:0000243)2.36846562
54Gait imbalance (HP:0002141)2.35193654
55Increased nuchal translucency (HP:0010880)2.33622434
56Genital tract atresia (HP:0001827)2.32409257
57Cerebellar dysplasia (HP:0007033)2.29756909
58Proximal placement of thumb (HP:0009623)2.28397986
59Intestinal atresia (HP:0011100)2.27415815
60Short humerus (HP:0005792)2.26965626
61Macroorchidism (HP:0000053)2.26332344
62Abnormality of the gastric mucosa (HP:0004295)2.24442391
63Nephrogenic diabetes insipidus (HP:0009806)2.24433172
64Sclerocornea (HP:0000647)2.23971993
65Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.23792691
66Malignant gastrointestinal tract tumors (HP:0006749)2.23357823
67Gastrointestinal carcinoma (HP:0002672)2.23357823
68Nail dystrophy (HP:0008404)2.21538103
69Asplenia (HP:0001746)2.21390626
70* Aplasia/Hypoplasia of the spleen (HP:0010451)2.21390626
71Oligodontia (HP:0000677)2.21303364
72Micronodular cirrhosis (HP:0001413)2.21035599
73Chronic hepatic failure (HP:0100626)2.17602676
74Aplasia/Hypoplasia of the tongue (HP:0010295)2.17068151
75Bifid tongue (HP:0010297)2.15083841
76Elfin facies (HP:0004428)2.14190698
77Upper limb muscle weakness (HP:0003484)2.14057034
78Tongue fasciculations (HP:0001308)2.13517417
79Rib fusion (HP:0000902)2.10802159
80Keratoconus (HP:0000563)2.10362222
81Increased corneal curvature (HP:0100692)2.10362222
82Pili torti (HP:0003777)2.09546001
83Hypoplasia of the capital femoral epiphysis (HP:0003090)2.09300853
84Supernumerary spleens (HP:0009799)2.09254022
85Pseudobulbar signs (HP:0002200)2.08524620
86Muscle fibrillation (HP:0010546)2.08068149
87Short 5th finger (HP:0009237)2.07583187
88Aplasia/hypoplasia of the humerus (HP:0006507)2.05165522
89Congenital hepatic fibrosis (HP:0002612)2.02912007
90Preaxial hand polydactyly (HP:0001177)2.02090512
91Postaxial hand polydactyly (HP:0001162)2.01526276
92Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.00665567
93Abnormality of the nasal septum (HP:0000419)2.00337111
94Esophageal atresia (HP:0002032)1.99712146
95* Anophthalmia (HP:0000528)1.99301858
96Male pseudohermaphroditism (HP:0000037)1.98178841
97Transitional cell carcinoma of the bladder (HP:0006740)1.98010350
98Attenuation of retinal blood vessels (HP:0007843)1.97849135
99Upper limb amyotrophy (HP:0009129)1.93870024
100Distal upper limb amyotrophy (HP:0007149)1.93870024
101Hypopigmentation of the fundus (HP:0007894)1.92687770
102Deviation of the hallux (HP:0010051)1.92405553
103Hypoplastic ischia (HP:0003175)1.91523588
104Hand muscle atrophy (HP:0009130)1.91469230
105Lymphangioma (HP:0100764)1.90943185
106Focal segmental glomerulosclerosis (HP:0000097)1.89668816
107Skin tags (HP:0010609)1.89225150
108Persistence of primary teeth (HP:0006335)1.89136865
109Bladder carcinoma (HP:0002862)1.88079478
110Bladder neoplasm (HP:0009725)1.88079478
111Preauricular skin tag (HP:0000384)1.88056667
112Pointed chin (HP:0000307)1.87567767
113Fused cervical vertebrae (HP:0002949)1.86983641
114Vitreoretinal degeneration (HP:0000655)1.86697992
115Hypoplasia of dental enamel (HP:0006297)1.84636038
116Disproportionate short-trunk short stature (HP:0003521)1.84191946
117Abnormality of the renal cortex (HP:0011035)1.83682514
118Absent hand (HP:0004050)1.83600831
119Renal dysplasia (HP:0000110)1.83553451
120Gastrointestinal atresia (HP:0002589)1.83097742
121Congenital, generalized hypertrichosis (HP:0004540)1.82892283
122Bony spicule pigmentary retinopathy (HP:0007737)1.82419583
123Abnormality of the phalanges of the 2nd finger (HP:0009541)1.81856102
124Shawl scrotum (HP:0000049)1.81600075
125Abnormal number of incisors (HP:0011064)1.81562148
126Chronic bronchitis (HP:0004469)1.81228564
127Abnormality of the frontal sinuses (HP:0002687)1.81015622
128Ureteral stenosis (HP:0000071)1.80973691
129Abnormal rod and cone electroretinograms (HP:0008323)1.80259130
130Microretrognathia (HP:0000308)1.79945594
131Bladder diverticulum (HP:0000015)1.78427999
132Hallux valgus (HP:0001822)1.77975383
133Facial cleft (HP:0002006)1.77118940
134Abnormality of the ischium (HP:0003174)1.77109207
135Broad toe (HP:0001837)1.77105730
136Midline defect of the nose (HP:0004122)1.76250910
137Ureteral obstruction (HP:0006000)1.74873920
138Broad phalanges of the hand (HP:0009768)1.74767189
139Retinal dysplasia (HP:0007973)1.74574558
140Short middle phalanx of the 5th finger (HP:0004220)1.74344839
141Cerebral aneurysm (HP:0004944)1.73694651
142Aganglionic megacolon (HP:0002251)1.73365897
143Cutaneous finger syndactyly (HP:0010554)1.73318351
144Esophageal varix (HP:0002040)1.72609856
145Abnormal biliary tract physiology (HP:0012439)1.72520441
146Bile duct proliferation (HP:0001408)1.72520441
147Hyperventilation (HP:0002883)1.71997756
148Ankyloglossia (HP:0010296)1.71319512
149Abnormality of the phalanges of the hallux (HP:0010057)1.71020985
150Periauricular skin pits (HP:0100277)1.70780882
151Preauricular pit (HP:0004467)1.70780882
152Abnormality of the diencephalon (HP:0010662)1.70717062
153Bronchomalacia (HP:0002780)1.70680677
154Mitral valve prolapse (HP:0001634)1.70478346
155Ankle contracture (HP:0006466)1.70378877
156Amblyopia (HP:0000646)1.70243195
157Wrist flexion contracture (HP:0001239)1.70098696
158Genetic anticipation (HP:0003743)1.68786005
159Mesomelia (HP:0003027)1.68424093
160Insomnia (HP:0100785)1.68138683
161Germ cell neoplasia (HP:0100728)1.67525534
162Split foot (HP:0001839)1.67315674
163Flat cornea (HP:0007720)1.67284571
164Broad finger (HP:0001500)1.67052178
165Hypothermia (HP:0002045)1.66026513
166Long palpebral fissure (HP:0000637)1.66009015
167Protrusio acetabuli (HP:0003179)1.65136222
168Polydipsia (HP:0001959)1.63436581
169Abnormal drinking behavior (HP:0030082)1.63436581
170Lissencephaly (HP:0001339)1.62330337
171Abnormality of macular pigmentation (HP:0008002)1.61860325
172Obsessive-compulsive behavior (HP:0000722)1.61730954
173Synostosis of carpal bones (HP:0005048)1.61477484
174Asymmetry of the thorax (HP:0001555)1.60796319
175Median cleft lip (HP:0000161)1.60717608
176Oligohydramnios (HP:0001562)1.60311747
177Optic nerve hypoplasia (HP:0000609)1.60286755
178Skin pits (HP:0100276)1.60067430
179Abnormality of the distal phalanges of the toes (HP:0010182)1.59856736
180Abnormality of the parathyroid morphology (HP:0011766)1.59661906
181Nuclear cataract (HP:0100018)1.59561852
182Preaxial foot polydactyly (HP:0001841)1.59378152
183Patellar aplasia (HP:0006443)1.58190536
184Optic nerve coloboma (HP:0000588)1.56900210
185Dandy-Walker malformation (HP:0001305)1.55185857
186Poor coordination (HP:0002370)1.54694739
187Highly arched eyebrow (HP:0002553)1.53282919
188Multicystic kidney dysplasia (HP:0000003)1.52463047
189Hyperglycinuria (HP:0003108)1.52409903
190Narrow forehead (HP:0000341)1.52038192
191Polyuria (HP:0000103)1.51893995
192Aplasia/Hypoplasia of the patella (HP:0006498)1.49402198
193Patent foramen ovale (HP:0001655)1.48515567
194Broad-based gait (HP:0002136)1.47265515
195Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.47001148
196Decreased circulating renin level (HP:0003351)1.46888872
197Severe muscular hypotonia (HP:0006829)1.46201440
198Cutaneous syndactyly (HP:0012725)1.46079911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.63571730
2CDK125.11624108
3EPHA24.90155353
4FRK3.14074236
5PLK42.68681097
6BMX2.53831670
7PTK62.52353743
8LATS12.44883002
9WNK42.40313527
10BMPR1B2.37935459
11EEF2K2.31551877
12TRIB32.28266336
13MAP3K102.16574360
14ADRBK22.08699811
15EPHB22.00758361
16WNK31.95039814
17GRK11.92655013
18DDR21.91651762
19CASK1.80617937
20TSSK61.75240989
21MAP4K21.74498919
22PTK21.70916480
23PDGFRA1.70004951
24FLT31.68042101
25EPHA41.66342332
26PKN21.58346458
27MAPK151.55252013
28TYRO31.54835362
29PAK41.54736548
30STK101.54365378
31CDK191.52477290
32TGFBR11.52355340
33SIK11.52283130
34ERBB41.51379594
35MAP2K21.50607874
36FER1.49691046
37RPS6KB21.48121214
38VRK21.47274813
39TTN1.40139511
40INSRR1.38635872
41CAMK1D1.37108311
42TESK11.37105247
43CSNK1G11.36008428
44ZAK1.35339831
45LATS21.34787393
46MKNK21.33090711
47ACVR1B1.32841451
48FGFR11.31291220
49CSNK1G31.30461561
50FGFR21.29631760
51NME11.29255957
52DAPK21.25727659
53CSNK1A1L1.23818768
54WEE11.22808335
55STK161.21719704
56STK38L1.20129038
57DYRK21.18002190
58CSNK1G21.17360310
59CDK81.16471092
60STK391.15304144
61NUAK11.14052261
62MST41.13366292
63ICK1.10460386
64MTOR1.10422853
65ERN11.09385768
66TLK11.07448427
67RIPK11.06510694
68OXSR11.05691080
69CDK71.04191519
70PRKCE1.02968830
71CAMK1G1.02952662
72KSR11.01741757
73BRSK21.00413732
74ALK0.99279398
75BRD40.95094354
76MAP3K40.91253023
77MELK0.88045586
78ERBB20.87223602
79NEK10.86373267
80PRKD30.86024922
81PINK10.85279541
82LRRK20.84142177
83MET0.82051428
84PRKCI0.81710932
85MAP3K70.79853432
86PBK0.78374870
87PTK2B0.77734423
88TAF10.77633570
89BCKDK0.77083482
90PASK0.76527460
91EPHB10.76304301
92EPHA30.76127955
93DYRK1B0.76006387
94BCR0.74215104
95NEK20.72913004
96MAP2K10.72731729
97AKT20.71961807
98AKT30.71245550
99LIMK10.70964846
100PNCK0.70507405
101CHEK20.69342358
102PAK20.68992459
103ATR0.68906483
104TRIM280.68152574
105TTK0.66980442
106ROCK20.65329093
107GRK50.63518241
108DYRK30.63456725
109VRK10.63194014
110MAP3K80.62775637
111BRSK10.61071548
112WNK10.60930170
113NTRK30.58622273
114RET0.57574581
115GRK60.57315200
116PLK20.57215537
117PRKG20.56708682
118CDK90.56062804
119LMTK20.55752255
120CAMK40.54898381
121CDC42BPA0.54693999
122MATK0.53065624
123MKNK10.52760093
124CHUK0.52621180
125IRAK10.52260176
126ADRBK10.51968207
127CDK60.48863454
128NTRK10.48743783
129TGFBR20.48264885
130PRKCG0.48013263
131CSNK1E0.47390371
132PDGFRB0.47123472
133MST1R0.46597435
134CHEK10.46508928
135ERBB30.46168578
136CSNK1A10.45240783
137PAK30.44300959
138STK30.44264965
139MAPK130.44182181
140SRC0.43864760
141MAP2K70.42633764
142CCNB10.41740454
143CDK40.41506562
144PHKG10.39146674
145PHKG20.39146674
146FGFR30.38553571
147INSR0.38429525
148IGF1R0.34688382
149TESK20.34480078
150PLK30.34392177
151ATM0.34245493
152TNIK0.33597315
153PLK10.33466139
154EGFR0.33286933
155NLK0.32147028
156CSF1R0.31203270
157CSNK1D0.30835745
158ROCK10.30194472
159MAPK80.29179978
160KSR20.27683626
161KDR0.27181536
162DMPK0.26035347

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.32497933
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.84856567
3Hippo signaling pathway_Homo sapiens_hsa043902.81416437
4Adherens junction_Homo sapiens_hsa045202.52563271
5Small cell lung cancer_Homo sapiens_hsa052222.26072371
6Phototransduction_Homo sapiens_hsa047442.25030614
7Hedgehog signaling pathway_Homo sapiens_hsa043402.20841340
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.20213179
9Proteoglycans in cancer_Homo sapiens_hsa052052.01290473
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.98684233
11Caffeine metabolism_Homo sapiens_hsa002321.97101889
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91539449
13Fanconi anemia pathway_Homo sapiens_hsa034601.78171075
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.77705873
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.77450913
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76634743
17Wnt signaling pathway_Homo sapiens_hsa043101.71561665
18ECM-receptor interaction_Homo sapiens_hsa045121.69627229
19RNA polymerase_Homo sapiens_hsa030201.69508242
20Homologous recombination_Homo sapiens_hsa034401.68970517
21Focal adhesion_Homo sapiens_hsa045101.65309707
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.64861255
23MicroRNAs in cancer_Homo sapiens_hsa052061.64310013
24Tight junction_Homo sapiens_hsa045301.63611672
25Thyroid cancer_Homo sapiens_hsa052161.62158406
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.60713441
27Endometrial cancer_Homo sapiens_hsa052131.59478330
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57498854
29Thyroid hormone signaling pathway_Homo sapiens_hsa049191.56200645
30Base excision repair_Homo sapiens_hsa034101.53937819
31Selenocompound metabolism_Homo sapiens_hsa004501.52561506
32Melanogenesis_Homo sapiens_hsa049161.50529502
33TGF-beta signaling pathway_Homo sapiens_hsa043501.48526486
34Non-homologous end-joining_Homo sapiens_hsa034501.47927035
35Pathways in cancer_Homo sapiens_hsa052001.47163026
36Notch signaling pathway_Homo sapiens_hsa043301.44469240
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43893940
38Colorectal cancer_Homo sapiens_hsa052101.43207501
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.41863228
40Cyanoamino acid metabolism_Homo sapiens_hsa004601.41472559
41HTLV-I infection_Homo sapiens_hsa051661.39850169
42ABC transporters_Homo sapiens_hsa020101.39640592
43Axon guidance_Homo sapiens_hsa043601.39057725
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.38390250
45mTOR signaling pathway_Homo sapiens_hsa041501.35012300
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34250121
47Renal cell carcinoma_Homo sapiens_hsa052111.33460324
48Chronic myeloid leukemia_Homo sapiens_hsa052201.31939568
49Chemical carcinogenesis_Homo sapiens_hsa052041.28762863
50HIF-1 signaling pathway_Homo sapiens_hsa040661.27192385
51Protein export_Homo sapiens_hsa030601.26983333
52Viral myocarditis_Homo sapiens_hsa054161.26909342
53Basal transcription factors_Homo sapiens_hsa030221.25125371
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.24556479
55Toxoplasmosis_Homo sapiens_hsa051451.24378613
56RNA degradation_Homo sapiens_hsa030181.23843553
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23080254
58Dorso-ventral axis formation_Homo sapiens_hsa043201.22855333
59Mismatch repair_Homo sapiens_hsa034301.22779235
60Rap1 signaling pathway_Homo sapiens_hsa040151.22187512
61Linoleic acid metabolism_Homo sapiens_hsa005911.20878995
62Nitrogen metabolism_Homo sapiens_hsa009101.20174485
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18986702
64Pancreatic cancer_Homo sapiens_hsa052121.18610730
65Central carbon metabolism in cancer_Homo sapiens_hsa052301.18247513
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17688398
67Tyrosine metabolism_Homo sapiens_hsa003501.17109136
68Ether lipid metabolism_Homo sapiens_hsa005651.15640048
69Glycosaminoglycan degradation_Homo sapiens_hsa005311.14102504
70Steroid biosynthesis_Homo sapiens_hsa001001.12669028
71Bladder cancer_Homo sapiens_hsa052191.12416413
72Nucleotide excision repair_Homo sapiens_hsa034201.12386752
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12316312
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11903494
75Cell cycle_Homo sapiens_hsa041101.09751119
76Glutathione metabolism_Homo sapiens_hsa004801.07940295
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07134643
78One carbon pool by folate_Homo sapiens_hsa006701.06257360
79Huntingtons disease_Homo sapiens_hsa050161.05165248
80Oxidative phosphorylation_Homo sapiens_hsa001901.04724632
81Prostate cancer_Homo sapiens_hsa052151.04591102
82Insulin secretion_Homo sapiens_hsa049111.02822479
83Regulation of actin cytoskeleton_Homo sapiens_hsa048101.02420887
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01607728
85Amoebiasis_Homo sapiens_hsa051461.01332354
86Cysteine and methionine metabolism_Homo sapiens_hsa002701.01291811
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98581097
88Histidine metabolism_Homo sapiens_hsa003400.97734139
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97663150
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96398467
91RNA transport_Homo sapiens_hsa030130.95402083
92Non-small cell lung cancer_Homo sapiens_hsa052230.95227969
93Gastric acid secretion_Homo sapiens_hsa049710.91950275
94Bile secretion_Homo sapiens_hsa049760.91787850
95Butanoate metabolism_Homo sapiens_hsa006500.91783428
96Tryptophan metabolism_Homo sapiens_hsa003800.91260794
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.91220420
98VEGF signaling pathway_Homo sapiens_hsa043700.91023585
99Pyrimidine metabolism_Homo sapiens_hsa002400.90507522
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90401917
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89232903
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89078829
103N-Glycan biosynthesis_Homo sapiens_hsa005100.88957794
104Estrogen signaling pathway_Homo sapiens_hsa049150.88554967
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.87715756
106beta-Alanine metabolism_Homo sapiens_hsa004100.87320843
107Glioma_Homo sapiens_hsa052140.87296042
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85808170
109Ovarian steroidogenesis_Homo sapiens_hsa049130.85708708
110Propanoate metabolism_Homo sapiens_hsa006400.85503310
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85091528
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84891848
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84220435
114Melanoma_Homo sapiens_hsa052180.83736235
115Nicotine addiction_Homo sapiens_hsa050330.83037155
116Peroxisome_Homo sapiens_hsa041460.81892240
117Gap junction_Homo sapiens_hsa045400.81674470
118Taste transduction_Homo sapiens_hsa047420.81587808
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78437923
120Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78320630
121Phenylalanine metabolism_Homo sapiens_hsa003600.76436782
122Thyroid hormone synthesis_Homo sapiens_hsa049180.76408491
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.76116765
124Dilated cardiomyopathy_Homo sapiens_hsa054140.76097448
125Metabolic pathways_Homo sapiens_hsa011000.75910636
126Regulation of autophagy_Homo sapiens_hsa041400.75401972
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.74299654
128Choline metabolism in cancer_Homo sapiens_hsa052310.74115781
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74057691
130Acute myeloid leukemia_Homo sapiens_hsa052210.73757981
131DNA replication_Homo sapiens_hsa030300.73456746
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72846477
133Purine metabolism_Homo sapiens_hsa002300.72388402
134Antigen processing and presentation_Homo sapiens_hsa046120.71867298
135Folate biosynthesis_Homo sapiens_hsa007900.71291290
136mRNA surveillance pathway_Homo sapiens_hsa030150.70474010
137GnRH signaling pathway_Homo sapiens_hsa049120.70256538
138Ribosome_Homo sapiens_hsa030100.68330476
139Parkinsons disease_Homo sapiens_hsa050120.67824881
140Vitamin B6 metabolism_Homo sapiens_hsa007500.67705962
141Oocyte meiosis_Homo sapiens_hsa041140.67594060
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66577330
143Mineral absorption_Homo sapiens_hsa049780.64292563
144Collecting duct acid secretion_Homo sapiens_hsa049660.63751198
145Ras signaling pathway_Homo sapiens_hsa040140.63658743
146Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62095586
147Arginine and proline metabolism_Homo sapiens_hsa003300.61911212
148Proteasome_Homo sapiens_hsa030500.60391007
149Viral carcinogenesis_Homo sapiens_hsa052030.59981935
150Endocytosis_Homo sapiens_hsa041440.59169598
151Cardiac muscle contraction_Homo sapiens_hsa042600.58823618
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57491164
153Apoptosis_Homo sapiens_hsa042100.57138040
154Prolactin signaling pathway_Homo sapiens_hsa049170.56332746
155ErbB signaling pathway_Homo sapiens_hsa040120.55619107
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54385851
157AMPK signaling pathway_Homo sapiens_hsa041520.53174572
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51807882
159Arachidonic acid metabolism_Homo sapiens_hsa005900.51409593
160p53 signaling pathway_Homo sapiens_hsa041150.49728029
161Salmonella infection_Homo sapiens_hsa051320.48381848
162Sulfur relay system_Homo sapiens_hsa041220.47204660
163Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46867005
164Salivary secretion_Homo sapiens_hsa049700.46836524
165Hepatitis B_Homo sapiens_hsa051610.46739455
166Protein digestion and absorption_Homo sapiens_hsa049740.46569998
167FoxO signaling pathway_Homo sapiens_hsa040680.45904607
168Primary bile acid biosynthesis_Homo sapiens_hsa001200.45387265
169Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45204533
170Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43974352
171Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43263396
172Insulin resistance_Homo sapiens_hsa049310.42791630
173cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39492165
174MAPK signaling pathway_Homo sapiens_hsa040100.39322239
175Oxytocin signaling pathway_Homo sapiens_hsa049210.38143143
176Lysine degradation_Homo sapiens_hsa003100.36591737
177Retinol metabolism_Homo sapiens_hsa008300.34461088
178Fructose and mannose metabolism_Homo sapiens_hsa000510.34340584
179Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33833881

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