STRADA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.08642686
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.13449296
3negative regulation of cell killing (GO:0031342)5.13449296
4regulation of B cell receptor signaling pathway (GO:0050855)4.79414116
5positive regulation of B cell differentiation (GO:0045579)4.71196739
6positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.69475029
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.64044286
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.64044286
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.64044286
10modulation by symbiont of host immune response (GO:0052553)4.64044286
11positive regulation by symbiont of host defense response (GO:0052509)4.64044286
12modulation by symbiont of host defense response (GO:0052031)4.64044286
13negative regulation of erythrocyte differentiation (GO:0045647)4.51378317
14regulation of gamma-delta T cell activation (GO:0046643)4.32580420
15antigen processing and presentation of endogenous antigen (GO:0019883)4.25783651
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24309174
17cellular extravasation (GO:0045123)4.23845250
18B cell receptor signaling pathway (GO:0050853)4.15796920
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.10871893
20regulation of gamma-delta T cell differentiation (GO:0045586)4.08488602
21response to muramyl dipeptide (GO:0032495)4.04393727
22negative thymic T cell selection (GO:0045060)4.03249526
23regulation of B cell differentiation (GO:0045577)4.00364602
24positive thymic T cell selection (GO:0045059)3.99132587
25neutrophil activation involved in immune response (GO:0002283)3.96908223
26response to peptidoglycan (GO:0032494)3.96335768
27DNA deamination (GO:0045006)3.95848090
28maturation of SSU-rRNA (GO:0030490)3.88431569
29leukocyte aggregation (GO:0070486)3.87764474
30immunoglobulin mediated immune response (GO:0016064)3.86402211
31ribosomal small subunit assembly (GO:0000028)3.84966487
32negative T cell selection (GO:0043383)3.80003406
33regulation of mast cell degranulation (GO:0043304)3.73847593
34antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71166932
35detection of other organism (GO:0098543)3.69020475
36detection of bacterium (GO:0016045)3.65863339
37DNA strand elongation involved in DNA replication (GO:0006271)3.64645203
38negative regulation of interleukin-12 production (GO:0032695)3.62017566
39DNA strand elongation (GO:0022616)3.54839831
40telomere maintenance via semi-conservative replication (GO:0032201)3.50007637
41response to host immune response (GO:0052572)3.49802599
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.49802599
43regulation of mast cell activation involved in immune response (GO:0033006)3.49178385
44viral mRNA export from host cell nucleus (GO:0046784)3.48746503
45positive regulation of granulocyte differentiation (GO:0030854)3.46299524
46DNA replication initiation (GO:0006270)3.43278324
47macrophage activation involved in immune response (GO:0002281)3.41123681
48regulation of myeloid leukocyte mediated immunity (GO:0002886)3.36484663
49mucosal-associated lymphoid tissue development (GO:0048537)3.36423245
50Peyers patch development (GO:0048541)3.36423245
51positive regulation of mast cell activation (GO:0033005)3.34754860
52DNA replication checkpoint (GO:0000076)3.29140304
53negative regulation of lymphocyte mediated immunity (GO:0002707)3.28950819
54response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.27220637
55response to host (GO:0075136)3.27220637
56response to host defenses (GO:0052200)3.27220637
57respiratory burst (GO:0045730)3.26436542
58positive T cell selection (GO:0043368)3.25788142
59formation of translation preinitiation complex (GO:0001731)3.23079085
60histone H2A acetylation (GO:0043968)3.20403508
61thymic T cell selection (GO:0045061)3.20290025
62proteasome assembly (GO:0043248)3.18911006
63microglial cell activation (GO:0001774)3.18674782
64telomere maintenance via recombination (GO:0000722)3.16811826
65T cell selection (GO:0045058)3.16608130
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15170312
67response to interleukin-15 (GO:0070672)3.15027360
68negative regulation of leukocyte mediated immunity (GO:0002704)3.14826181
69myeloid cell activation involved in immune response (GO:0002275)3.13614559
70regulation of leukocyte degranulation (GO:0043300)3.13160617
71detection of external biotic stimulus (GO:0098581)3.11768370
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.10685844
73positive regulation of mast cell degranulation (GO:0043306)3.10685844
74Arp2/3 complex-mediated actin nucleation (GO:0034314)3.08467875
75histone H3-K36 demethylation (GO:0070544)3.06905226
76anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06853969
77mitotic nuclear envelope disassembly (GO:0007077)3.05838385
78positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.04684506
79regulation of mast cell activation (GO:0033003)3.01630394
80mitotic metaphase plate congression (GO:0007080)3.00950736
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.00763604
82regulation of alpha-beta T cell proliferation (GO:0046640)3.00504201
83negative regulation of T cell mediated immunity (GO:0002710)3.00031902
84DNA unwinding involved in DNA replication (GO:0006268)2.98875031
85regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98638032
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.97921992
87ribosomal small subunit biogenesis (GO:0042274)2.97199922
88defense response to protozoan (GO:0042832)2.96921629
89neutrophil activation (GO:0042119)2.96840311
90establishment of integrated proviral latency (GO:0075713)2.96338395
91nucleobase biosynthetic process (GO:0046112)2.96208204
92positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.94984909
93B cell mediated immunity (GO:0019724)2.94950469
94piRNA metabolic process (GO:0034587)2.92894779
95spliceosomal snRNP assembly (GO:0000387)2.92373886
96mannose metabolic process (GO:0006013)2.89909783
97leukocyte degranulation (GO:0043299)2.89774771
98mast cell activation (GO:0045576)2.88813297
99rRNA modification (GO:0000154)2.88614469
100viral transcription (GO:0019083)2.88549988
101mitotic recombination (GO:0006312)2.87086696
102telomere maintenance via telomere lengthening (GO:0010833)2.87050814
103metaphase plate congression (GO:0051310)2.86861400
104germinal center formation (GO:0002467)2.83936433
105purine nucleobase biosynthetic process (GO:0009113)2.83705984
106T cell migration (GO:0072678)2.83410964
107cellular response to interleukin-15 (GO:0071350)2.82590205
108nuclear envelope disassembly (GO:0051081)2.81795405
109membrane disassembly (GO:0030397)2.81795405
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81359020
111detection of biotic stimulus (GO:0009595)2.81224077
112translational termination (GO:0006415)2.80337113
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.79939728
114negative regulation of ligase activity (GO:0051352)2.79939728
115detection of molecule of bacterial origin (GO:0032490)2.79841976
116activated T cell proliferation (GO:0050798)2.79233037
117actin filament polymerization (GO:0030041)2.78471344
118maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78074865
119translesion synthesis (GO:0019985)2.77629502
120positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.77232980
121interferon-gamma-mediated signaling pathway (GO:0060333)2.76932643
122tolerance induction (GO:0002507)2.76270976
123regulation of granulocyte differentiation (GO:0030852)2.75826662
124granulocyte activation (GO:0036230)2.73601773
125macrophage activation (GO:0042116)2.73212035
126rRNA processing (GO:0006364)2.73207190
127replication fork processing (GO:0031297)2.73189661
128antigen processing and presentation via MHC class Ib (GO:0002475)2.73177717
129kinetochore assembly (GO:0051382)2.72228376
130nucleotide-excision repair, DNA gap filling (GO:0006297)2.71880894
131chromatin remodeling at centromere (GO:0031055)2.71618342
132termination of RNA polymerase I transcription (GO:0006363)2.70442060
133response to protozoan (GO:0001562)2.70387173
134regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.70267292
135termination of RNA polymerase III transcription (GO:0006386)2.69713931
136transcription elongation from RNA polymerase III promoter (GO:0006385)2.69713931
137positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.69626982
138CENP-A containing nucleosome assembly (GO:0034080)2.69378621
1397-methylguanosine mRNA capping (GO:0006370)2.69356338
140positive regulation of interleukin-17 production (GO:0032740)2.69335534
141type I interferon signaling pathway (GO:0060337)2.69079738
142cellular response to type I interferon (GO:0071357)2.69079738
143kinetochore organization (GO:0051383)2.68655764
144negative regulation of innate immune response (GO:0045824)2.68065811
145response to type I interferon (GO:0034340)2.67819956
146translational initiation (GO:0006413)2.66770207
147intra-S DNA damage checkpoint (GO:0031573)2.66293604
148ribosomal large subunit biogenesis (GO:0042273)2.65835263
149antigen receptor-mediated signaling pathway (GO:0050851)2.65043969
150negative regulation of phagocytosis (GO:0050765)2.64137815
151establishment of chromosome localization (GO:0051303)2.63768716
152positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.63707096
153microtubule depolymerization (GO:0007019)2.63669320
154rRNA metabolic process (GO:0016072)2.62839846
155ribonucleoprotein complex biogenesis (GO:0022613)2.62660191
156regulation of ARF GTPase activity (GO:0032312)2.62332432
157RNA capping (GO:0036260)2.62221710
1587-methylguanosine RNA capping (GO:0009452)2.62221710
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.62066423
160signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.62066423
161signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61995415
162signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61995415
163signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61995415
164mitotic sister chromatid segregation (GO:0000070)2.61477307
165T cell proliferation (GO:0042098)2.61286282
166DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61093264
167translational elongation (GO:0006414)2.60400140
168regulation of regulated secretory pathway (GO:1903305)2.59853159
169DNA replication-independent nucleosome organization (GO:0034724)2.57470227
170DNA replication-independent nucleosome assembly (GO:0006336)2.57470227
171postreplication repair (GO:0006301)2.57041678
172signal transduction involved in DNA damage checkpoint (GO:0072422)2.56793168
173signal transduction involved in DNA integrity checkpoint (GO:0072401)2.56793168
174transcription-coupled nucleotide-excision repair (GO:0006283)2.56393859
175negative regulation of chromosome segregation (GO:0051985)2.54552377
176ribosome biogenesis (GO:0042254)2.54302157
177transcription elongation from RNA polymerase I promoter (GO:0006362)2.54255947
178negative regulation of mitotic sister chromatid separation (GO:2000816)2.53540741
179negative regulation of mitotic sister chromatid segregation (GO:0033048)2.53540741
180negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.53540741
181negative regulation of sister chromatid segregation (GO:0033046)2.53540741
182signal transduction involved in cell cycle checkpoint (GO:0072395)2.53078832
183rRNA methylation (GO:0031167)2.51311892
184histone exchange (GO:0043486)2.51152753
185positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50524505
186regulation of spindle organization (GO:0090224)2.50176372
187guanosine-containing compound biosynthetic process (GO:1901070)2.49411969
188nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.48991669
189mitotic spindle assembly checkpoint (GO:0007094)2.48941899
190pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.48189839
191regulation of centriole replication (GO:0046599)2.48088692
192DNA-templated transcription, termination (GO:0006353)2.47740526
193negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.46835547
194exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.46290280
195G1/S transition of mitotic cell cycle (GO:0000082)2.46282043
196cell cycle G1/S phase transition (GO:0044843)2.46282043
197positive regulation of ligase activity (GO:0051351)2.46027644
198regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.45978550
199DNA-dependent DNA replication (GO:0006261)2.45161682
200spindle assembly checkpoint (GO:0071173)2.44160563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.69813758
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.63075648
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.58331992
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.52959988
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.22820635
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.16185163
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.14495498
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10527422
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.08504470
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07696769
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.05325859
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.98193071
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.85367157
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.82985693
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81271558
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73521598
17VDR_24763502_ChIP-Seq_THP-1_Human2.65946858
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63594459
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60731834
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49425982
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.48732255
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46712466
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.42773855
24* VDR_23849224_ChIP-Seq_CD4+_Human2.42444160
25E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.41869050
26SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.39134745
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.38516764
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36263423
29MAF_26560356_Chip-Seq_TH1_Human2.35888549
30LXR_22292898_ChIP-Seq_THP-1_Human2.29410180
31KDM2B_26808549_Chip-Seq_DND41_Human2.28039188
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24355810
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23636487
34UTX_26944678_Chip-Seq_JUKART_Human2.21474233
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.18641977
36TCF7_22412390_ChIP-Seq_EML_Mouse2.18323050
37MAF_26560356_Chip-Seq_TH2_Human2.17100453
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.14809492
39* FOXP3_21729870_ChIP-Seq_TREG_Human2.14580004
40* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.13806992
41SPI1_23127762_ChIP-Seq_K562_Human2.13164576
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11618981
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09271509
44* XRN2_22483619_ChIP-Seq_HELA_Human2.08093547
45EGR1_19374776_ChIP-ChIP_THP-1_Human2.07019825
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06574273
47CIITA_25753668_ChIP-Seq_RAJI_Human2.04655331
48CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04585973
49RUNX1_22412390_ChIP-Seq_EML_Mouse2.01671798
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00018125
51NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.97934329
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.92927800
53KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92051185
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.91469990
55MYC_22102868_ChIP-Seq_BL_Human1.89583676
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89008841
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.88557628
58* DCP1A_22483619_ChIP-Seq_HELA_Human1.85961330
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.85558138
60GABP_19822575_ChIP-Seq_HepG2_Human1.84056113
61YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84002400
62STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83369144
63RUNX_20019798_ChIP-Seq_JUKART_Human1.81341017
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80433901
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80405308
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79294573
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76471977
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.75933871
69TTF2_22483619_ChIP-Seq_HELA_Human1.73989681
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.72518973
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71602050
72GATA1_19941827_ChIP-Seq_MEL_Mouse1.71309329
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.69733188
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67373327
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.63689154
76FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.60512739
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.59689184
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.59064660
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58414691
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57726979
81GATA1_22025678_ChIP-Seq_K562_Human1.57182113
82P68_20966046_ChIP-Seq_HELA_Human1.56993069
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56942901
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.54777471
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53899414
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.52617632
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51542690
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.48461326
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44274111
90BCL6_27268052_Chip-Seq_Bcells_Human1.44111601
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42853914
92NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42413089
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.41572935
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.40875901
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40344254
96NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39152543
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.37706221
98GATA3_27048872_Chip-Seq_THYMUS_Human1.37308163
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37155578
100ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32671525
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31721124
102* SPI1_23547873_ChIP-Seq_NB4_Human1.30908808
103PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30798069
104* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28158495
105SCL_19346495_ChIP-Seq_HPC-7_Human1.28017083
106ELK1_19687146_ChIP-ChIP_HELA_Human1.27614331
107BCOR_27268052_Chip-Seq_Bcells_Human1.27498052
108MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27067751
109ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26616986
110NCOR1_26117541_ChIP-Seq_K562_Human1.26519190
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26078489
112SA1_27219007_Chip-Seq_ERYTHROID_Human1.26033272
113CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24568503
114VDR_21846776_ChIP-Seq_THP-1_Human1.24542893
115KDM5A_27292631_Chip-Seq_BREAST_Human1.24520963
116SMC4_20622854_ChIP-Seq_HELA_Human1.24258197
117TET1_21451524_ChIP-Seq_MESCs_Mouse1.22546018
118AR_21909140_ChIP-Seq_LNCAP_Human1.21739295
119DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21519305
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20891436
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.18998748
122CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18666290
123STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16107771
124ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15802623
125RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15254489
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13862566
127CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12976728
128SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12844531
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12592406
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12247986
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11700301
132EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.11300787
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10500739
134KDM2B_26808549_Chip-Seq_K562_Human1.10307446
135ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09570572
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09415914
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09339592
138FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08869883
139IRF8_21731497_ChIP-ChIP_J774_Mouse1.08563409
140CTCF_26484167_Chip-Seq_Bcells_Mouse1.08352778
141* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07576583
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07492119
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06478333
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06027755
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05849894
146CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04246332
147RACK7_27058665_Chip-Seq_MCF-7_Human1.02146088
148GATA1_19941826_ChIP-Seq_K562_Human1.01562844
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.01355258
150FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99784229
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93657037
152MYC_18940864_ChIP-ChIP_HL60_Human0.92863933
153MYB_26560356_Chip-Seq_TH2_Human0.91314562
154KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90731619
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88974972
156BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87581746
157POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86476740
158TP63_19390658_ChIP-ChIP_HaCaT_Human0.85735832
159CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83555402
160CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82731151
161GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81315608
162STAT4_19710469_ChIP-ChIP_TH1__Mouse0.81275873
163RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80948199
164LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80853409
165LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.79681786
166PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78996978
167SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78282881
168TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.77766483
169CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77524914
170MYB_26560356_Chip-Seq_TH1_Human0.77221763
171ELK1_22589737_ChIP-Seq_MCF10A_Human0.77074446
172PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76543372

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.06740829
2MP0003693_abnormal_embryo_hatching3.77843287
3MP0003436_decreased_susceptibility_to3.69490079
4MP0010094_abnormal_chromosome_stability3.67659663
5MP0008057_abnormal_DNA_replication3.27123181
6MP0003111_abnormal_nucleus_morphology3.20057679
7MP0002396_abnormal_hematopoietic_system3.15789640
8MP0003172_abnormal_lysosome_physiology3.03943843
9MP0008877_abnormal_DNA_methylation2.96894197
10MP0003077_abnormal_cell_cycle2.90720266
11MP0008058_abnormal_DNA_repair2.87125612
12MP0002419_abnormal_innate_immunity2.80015110
13MP0005058_abnormal_lysosome_morphology2.75099412
14MP0004957_abnormal_blastocyst_morpholog2.68119811
15MP0003724_increased_susceptibility_to2.59704678
16MP0005410_abnormal_fertilization2.36284714
17MP0003191_abnormal_cellular_cholesterol2.24594780
18MP0005671_abnormal_response_to2.08526149
19MP0006292_abnormal_olfactory_placode2.04336057
20MP0008007_abnormal_cellular_replicative2.00242788
21MP0003763_abnormal_thymus_physiology1.99521830
22MP0002148_abnormal_hypersensitivity_rea1.93774672
23MP0003123_paternal_imprinting1.85908727
24MP0004808_abnormal_hematopoietic_stem1.85623292
25MP0001986_abnormal_taste_sensitivity1.83857083
26MP0001835_abnormal_antigen_presentation1.83568628
27MP0002398_abnormal_bone_marrow1.77442776
28MP0004147_increased_porphyrin_level1.75754284
29MP0003786_premature_aging1.72676223
30MP0003300_gastrointestinal_ulcer1.69915810
31MP0006082_CNS_inflammation1.69848339
32MP0001929_abnormal_gametogenesis1.65591938
33MP0000703_abnormal_thymus_morphology1.58457580
34MP0002653_abnormal_ependyma_morphology1.55094011
35MP0004381_abnormal_hair_follicle1.54775513
36MP0001533_abnormal_skeleton_physiology1.54249258
37MP0005397_hematopoietic_system_phenotyp1.53896669
38MP0001545_abnormal_hematopoietic_system1.53896669
39MP0002722_abnormal_immune_system1.48208449
40MP0002210_abnormal_sex_determination1.47407969
41MP0000689_abnormal_spleen_morphology1.46504719
42MP0005174_abnormal_tail_pigmentation1.45791700
43MP0009333_abnormal_splenocyte_physiolog1.45630740
44MP0008932_abnormal_embryonic_tissue1.44432676
45MP0001800_abnormal_humoral_immune1.43346569
46MP0003698_abnormal_male_reproductive1.40718070
47MP0010155_abnormal_intestine_physiology1.40628255
48MP0005075_abnormal_melanosome_morpholog1.40079897
49MP0001845_abnormal_inflammatory_respons1.38882684
50MP0003646_muscle_fatigue1.36567298
51MP0002420_abnormal_adaptive_immunity1.35729150
52MP0001819_abnormal_immune_cell1.34290930
53MP0000015_abnormal_ear_pigmentation1.34164625
54MP0003880_abnormal_central_pattern1.32299052
55MP0003690_abnormal_glial_cell1.31815488
56MP0000716_abnormal_immune_system1.31523655
57MP0004947_skin_inflammation1.31014908
58MP0001529_abnormal_vocalization1.29873830
59MP0002429_abnormal_blood_cell1.26437299
60MP0003828_pulmonary_edema1.25597069
61MP0002452_abnormal_antigen_presenting1.22561529
62MP0003121_genomic_imprinting1.22488624
63MP0000490_abnormal_crypts_of1.22017619
64MP0002723_abnormal_immune_serum1.21710046
65MP0000350_abnormal_cell_proliferation1.21288092
66MP0002132_abnormal_respiratory_system1.21255352
67MP0000604_amyloidosis1.20865897
68MP0001145_abnormal_male_reproductive1.20372324
69MP0000313_abnormal_cell_death1.15907865
70MP0003950_abnormal_plasma_membrane1.12401905
71MP0008260_abnormal_autophagy1.10393540
72MP0002019_abnormal_tumor_incidence1.09511454
73MP0002998_abnormal_bone_remodeling1.08496252
74MP0000685_abnormal_immune_system1.08350651
75MP0001730_embryonic_growth_arrest1.07176980
76MP0003075_altered_response_to1.05369045
77MP0002095_abnormal_skin_pigmentation1.04699586
78MP0003329_amyloid_beta_deposits1.02361766
79MP0008469_abnormal_protein_level1.01203088
80MP0009764_decreased_sensitivity_to1.01153365
81MP0000653_abnormal_sex_gland1.00468207
82MP0000858_altered_metastatic_potential0.96351580
83MP0009765_abnormal_xenobiotic_induced0.96318838
84MP0005310_abnormal_salivary_gland0.95854441
85MP0004859_abnormal_synaptic_plasticity0.95772359
86MP0001697_abnormal_embryo_size0.94128553
87MP0002163_abnormal_gland_morphology0.93927860
88MP0000569_abnormal_digit_pigmentation0.92931743
89MP0002080_prenatal_lethality0.92271297
90MP0002102_abnormal_ear_morphology0.91905164
91MP0005423_abnormal_somatic_nervous0.91615187
92MP0002161_abnormal_fertility/fecundity0.91549813
93MP0003787_abnormal_imprinting0.87740451
94MP0003656_abnormal_erythrocyte_physiolo0.87488824
95MP0001905_abnormal_dopamine_level0.86962618
96MP0005000_abnormal_immune_tolerance0.86105119
97MP0000358_abnormal_cell_content/0.85505629
98MP0009785_altered_susceptibility_to0.84699862
99MP0008874_decreased_physiological_sensi0.84500657
100MP0001663_abnormal_digestive_system0.84471577
101MP0003567_abnormal_fetal_cardiomyocyte0.82511152
102MP0001672_abnormal_embryogenesis/_devel0.81524026
103MP0005380_embryogenesis_phenotype0.81524026
104MP0000920_abnormal_myelination0.81493647
105MP0002405_respiratory_system_inflammati0.81323195
106MP0009763_increased_sensitivity_to0.80947598
107MP0002933_joint_inflammation0.80607567
108MP0003866_abnormal_defecation0.79681235
109MP0005451_abnormal_body_composition0.78818764
110MP0001873_stomach_inflammation0.78764395
111MP0002160_abnormal_reproductive_system0.77948560
112MP0001853_heart_inflammation0.77819297
113MP0009278_abnormal_bone_marrow0.76485963
114MP0001851_eye_inflammation0.76109896
115MP0005390_skeleton_phenotype0.73968810
116MP0001849_ear_inflammation0.73766655
117MP0003718_maternal_effect0.73316262
118MP0005025_abnormal_response_to0.73071034
119MP0002085_abnormal_embryonic_tissue0.72532602
120MP0000465_gastrointestinal_hemorrhage0.72460546
121MP0000343_altered_response_to0.72032109
122MP0003984_embryonic_growth_retardation0.71719293
123MP0009046_muscle_twitch0.69168931
124MP0002088_abnormal_embryonic_growth/wei0.68550261
125MP0006035_abnormal_mitochondrial_morpho0.68441951
126MP0004883_abnormal_blood_vessel0.67805899
127MP0005384_cellular_phenotype0.65674882
128MP0002938_white_spotting0.64901281
129MP0001790_abnormal_immune_system0.63053024
130MP0005387_immune_system_phenotype0.63053024
131MP0005389_reproductive_system_phenotype0.63042483
132MP0010030_abnormal_orbit_morphology0.62089191
133MP0001293_anophthalmia0.61623276
134MP0003183_abnormal_peptide_metabolism0.61386203
135MP0005167_abnormal_blood-brain_barrier0.61045207
136MP0002089_abnormal_postnatal_growth/wei0.61026088
137MP0002075_abnormal_coat/hair_pigmentati0.59789329
138MP0003795_abnormal_bone_structure0.59237199
139MP0002084_abnormal_developmental_patter0.59058635
140MP0008569_lethality_at_weaning0.58358156
141MP0005464_abnormal_platelet_physiology0.58193655
142MP0005166_decreased_susceptibility_to0.58141781
143MP0003879_abnormal_hair_cell0.58109157
144MP0004510_myositis0.57518441
145MP0001188_hyperpigmentation0.57500832
146MP0002249_abnormal_larynx_morphology0.55481654
147MP0008961_abnormal_basal_metabolism0.54903184
148MP0002083_premature_death0.51355344
149MP0003448_altered_tumor_morphology0.50874367
150MP0005621_abnormal_cell_physiology0.48792597
151MP0005381_digestive/alimentary_phenotyp0.48333548
152MP0005248_abnormal_Harderian_gland0.46934473
153MP0002928_abnormal_bile_duct0.46137467
154MP0002064_seizures0.44427192
155MP0005171_absent_coat_pigmentation0.43285251
156MP0003634_abnormal_glial_cell0.43063560

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)5.27773739
2Eczematoid dermatitis (HP:0000976)4.97487106
3Recurrent fungal infections (HP:0002841)4.29062292
4Birth length less than 3rd percentile (HP:0003561)4.18718952
5Mediastinal lymphadenopathy (HP:0100721)4.16925596
6Abnormality of macrophages (HP:0004311)3.93486108
7Meningitis (HP:0001287)3.92492617
8Agammaglobulinemia (HP:0004432)3.82381145
9Stomatitis (HP:0010280)3.72681570
10Recurrent viral infections (HP:0004429)3.58706451
11Cellulitis (HP:0100658)3.48238539
12Abnormal number of erythroid precursors (HP:0012131)3.39729526
13Abnormal delayed hypersensitivity skin test (HP:0002963)3.37389013
14Chronic mucocutaneous candidiasis (HP:0002728)3.35195009
15Recurrent cutaneous fungal infections (HP:0011370)3.35195009
16Recurrent skin infections (HP:0001581)3.33227113
17Recurrent gram-negative bacterial infections (HP:0005420)3.33199134
18Abnormality of cells of the erythroid lineage (HP:0012130)3.30364521
19Colitis (HP:0002583)3.26857258
20Orchitis (HP:0100796)3.24776660
21Hypoplasia of the capital femoral epiphysis (HP:0003090)3.08473224
22Cerebral hypomyelination (HP:0006808)3.07526554
23Retrobulbar optic neuritis (HP:0100654)3.07150596
24Optic neuritis (HP:0100653)3.07150596
25Increased IgE level (HP:0003212)2.97398716
26Increased cerebral lipofuscin (HP:0011813)2.94773645
27Encephalitis (HP:0002383)2.90344781
28Spontaneous hematomas (HP:0007420)2.89264329
29Gastrointestinal inflammation (HP:0004386)2.86292307
30Urticaria (HP:0001025)2.82540033
31Reticulocytopenia (HP:0001896)2.80413092
32Type 2 muscle fiber atrophy (HP:0003554)2.76932325
33Vasculitis (HP:0002633)2.73732661
34Absent/shortened dynein arms (HP:0200106)2.72977451
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.72977451
36Inflammation of the large intestine (HP:0002037)2.72734912
37Muscle fiber atrophy (HP:0100295)2.72264927
38T lymphocytopenia (HP:0005403)2.68176194
39Gingivitis (HP:0000230)2.65618406
40Prolonged bleeding time (HP:0003010)2.64572063
41Thrombocytosis (HP:0001894)2.64315917
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.62625087
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.60903693
44Chest pain (HP:0100749)2.60890822
45Aplastic anemia (HP:0001915)2.60055754
46Breast hypoplasia (HP:0003187)2.58645340
47Rough bone trabeculation (HP:0100670)2.57694924
48IgM deficiency (HP:0002850)2.56967492
49Papilledema (HP:0001085)2.53859043
50Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48775506
51Absent epiphyses (HP:0010577)2.46981330
52Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.46981330
53Sepsis (HP:0100806)2.46693955
54Epistaxis (HP:0000421)2.45759829
55Loss of speech (HP:0002371)2.45009580
56Abnormality of the fingertips (HP:0001211)2.44873713
57Osteomyelitis (HP:0002754)2.43747167
58Abnormality of T cells (HP:0002843)2.42071505
59Myelodysplasia (HP:0002863)2.41467719
60Abnormal number of incisors (HP:0011064)2.41191586
61Abnormal respiratory epithelium morphology (HP:0012253)2.36719268
62Abnormal respiratory motile cilium morphology (HP:0005938)2.36719268
63Abnormality of the preputium (HP:0100587)2.34627558
64Patellar aplasia (HP:0006443)2.34450098
65Gastrointestinal stroma tumor (HP:0100723)2.34320726
66Gastrointestinal infarctions (HP:0005244)2.34256054
67Carpal bone hypoplasia (HP:0001498)2.34209656
68Panhypogammaglobulinemia (HP:0003139)2.32881502
69Visual hallucinations (HP:0002367)2.28970133
70Abnormality of the ileum (HP:0001549)2.28488807
71Dysostosis multiplex (HP:0000943)2.28316257
72Meckel diverticulum (HP:0002245)2.26457754
73Type I transferrin isoform profile (HP:0003642)2.26407076
74Abnormality of T cell number (HP:0011839)2.25696506
75Leukocytosis (HP:0001974)2.25056244
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22077725
77Hepatosplenomegaly (HP:0001433)2.21426566
78Chromsome breakage (HP:0040012)2.21287047
79Viral hepatitis (HP:0006562)2.19785429
80Hemoptysis (HP:0002105)2.19479472
81Abnormality of the heme biosynthetic pathway (HP:0010472)2.19034181
82Pulmonary infiltrates (HP:0002113)2.17004494
83Purpura (HP:0000979)2.16892779
84Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16400000
85Keratoconjunctivitis sicca (HP:0001097)2.16304103
86Thoracic kyphosis (HP:0002942)2.15767391
87Nasal polyposis (HP:0100582)2.15388484
88Metaphyseal cupping (HP:0003021)2.15134481
89Abnormality of the pleura (HP:0002103)2.15068129
90Peripheral hypomyelination (HP:0007182)2.14231369
91Aplasia/Hypoplasia of the patella (HP:0006498)2.12952422
92Severe combined immunodeficiency (HP:0004430)2.11783034
93Recurrent bronchitis (HP:0002837)2.10800545
94Slow saccadic eye movements (HP:0000514)2.08637545
95Pallor (HP:0000980)2.08236333
96Neuronal loss in central nervous system (HP:0002529)2.08202210
97Agnosia (HP:0010524)2.07832530
98Aplasia/Hypoplasia of the uvula (HP:0010293)2.07719822
99Bone marrow hypocellularity (HP:0005528)2.07557177
100Basal cell carcinoma (HP:0002671)2.06964829
101Hypochromic microcytic anemia (HP:0004840)2.06208783
102Abnormality of lateral ventricle (HP:0030047)2.05889377
103Elevated erythrocyte sedimentation rate (HP:0003565)2.05696067
104Prominent nose (HP:0000448)2.04937691
105Cleft eyelid (HP:0000625)2.04297886
106Petechiae (HP:0000967)2.04225140
107Episodic fever (HP:0001954)2.04201930
108Lymphoma (HP:0002665)2.02450147
109Chronic otitis media (HP:0000389)2.02434862
110Combined immunodeficiency (HP:0005387)2.01637901
111Pulmonary fibrosis (HP:0002206)2.01610845
112Abnormality of glycolipid metabolism (HP:0010969)2.01202309
113Abnormality of liposaccharide metabolism (HP:0010968)2.01202309
114Abnormality of glycosphingolipid metabolism (HP:0004343)2.01202309
115Premature graying of hair (HP:0002216)2.00752888
116Abnormality of the thoracic spine (HP:0100711)1.99374744
117Selective tooth agenesis (HP:0001592)1.98066725
118Myositis (HP:0100614)1.97944403
119Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97778822
120Abnormal spermatogenesis (HP:0008669)1.97259114
121Acute lymphatic leukemia (HP:0006721)1.97035778
122Increased IgM level (HP:0003496)1.95891104
123Severe visual impairment (HP:0001141)1.94480646
124Oral leukoplakia (HP:0002745)1.94049487
125Hypoplasia of the thymus (HP:0000778)1.93922592
126Hypergammaglobulinemia (HP:0010702)1.93138084
127Degeneration of anterior horn cells (HP:0002398)1.92525258
128Abnormality of the anterior horn cell (HP:0006802)1.92525258
129Supernumerary spleens (HP:0009799)1.92466929
130Restrictive lung disease (HP:0002091)1.91439487
131Abnormality of alanine metabolism (HP:0010916)1.91130852
132Hyperalaninemia (HP:0003348)1.91130852
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91130852
134Pustule (HP:0200039)1.91001681
135Premature ovarian failure (HP:0008209)1.90948809
136Gingival bleeding (HP:0000225)1.90092099
137Arterial thrombosis (HP:0004420)1.89113274
138Abnormal trabecular bone morphology (HP:0100671)1.87438163
139Microvesicular hepatic steatosis (HP:0001414)1.85753972
140Absent thumb (HP:0009777)1.85696056
141Eosinophilia (HP:0001880)1.85246950
142Cellular immunodeficiency (HP:0005374)1.85118594
143Chronic obstructive pulmonary disease (HP:0006510)1.84717643
144Obstructive lung disease (HP:0006536)1.84717643
145Keratoconjunctivitis (HP:0001096)1.84698253
14611 pairs of ribs (HP:0000878)1.83073951
147Hypochromic anemia (HP:0001931)1.82774006
148Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.81108947
149Amaurosis fugax (HP:0100576)1.80395602
150Hypoplasia of the radius (HP:0002984)1.79230928
151Recurrent lower respiratory tract infections (HP:0002783)1.79176864
152Verrucae (HP:0200043)1.78894190
153Papilloma (HP:0012740)1.78894190
154Recurrent sinusitis (HP:0011108)1.78873998
155Interstitial pulmonary disease (HP:0006530)1.77486159
156Skin ulcer (HP:0200042)1.77188588
157Abnormality of chromosome stability (HP:0003220)1.76979704
158Congenital stationary night blindness (HP:0007642)1.76817182
159Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76557989
160Granulocytopenia (HP:0001913)1.75314692
161Abnormality of eosinophils (HP:0001879)1.74649950
162Duodenal stenosis (HP:0100867)1.74538921
163Small intestinal stenosis (HP:0012848)1.74538921
164Sloping forehead (HP:0000340)1.73982748
165Postnatal microcephaly (HP:0005484)1.73905163
166Macrocytic anemia (HP:0001972)1.73298685
167Abnormality of the nasal mucosa (HP:0000433)1.72349435
168Pancytopenia (HP:0001876)1.71830936
169Abnormality of B cell number (HP:0010975)1.71654160
170B lymphocytopenia (HP:0010976)1.71654160
171CNS hypomyelination (HP:0003429)1.71485360
172Lymphopenia (HP:0001888)1.70572754
173IgG deficiency (HP:0004315)1.69834635
174Tracheoesophageal fistula (HP:0002575)1.69217153
175Abnormality of cells of the lymphoid lineage (HP:0012140)1.68559888
176Optic nerve coloboma (HP:0000588)1.67201916
177Rhinitis (HP:0012384)1.66806680
178Asplenia (HP:0001746)1.66794447
179Recurrent abscess formation (HP:0002722)1.66743821
180Abnormal respiratory motile cilium physiology (HP:0012261)1.66214435
181Bronchitis (HP:0012387)1.65947185
182Personality changes (HP:0000751)1.64898170
183Abnormality of the carotid arteries (HP:0005344)1.64586327
184Chronic sinusitis (HP:0011109)1.64441406

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.26690022
2WEE13.39570722
3PASK3.21017377
4STK163.19543420
5PRPF4B3.19241638
6ERN13.17528840
7TSSK63.15832228
8CCNB12.94033118
9MAP4K12.69528247
10VRK12.40892507
11CDC72.38179775
12FES2.22282898
13MAP2K32.21518875
14TNK22.18585210
15TYK22.12671551
16NEK22.08232600
17EIF2AK12.02618481
18PLK41.87002838
19SRPK11.84216408
20PDK31.80965280
21PDK41.80965280
22MAP3K121.80576680
23IKBKE1.74407171
24PNCK1.69650188
25BCKDK1.61498469
26MKNK21.61240410
27FGR1.60327930
28SIK21.59175970
29TRIB31.58744655
30CSK1.55526469
31TAOK31.55363839
32TNIK1.55023776
33ACVR1B1.49612746
34EPHB11.49434887
35PLK11.47651835
36HCK1.46781593
37MAP3K131.43483781
38MKNK11.42670539
39ITK1.41983980
40ATR1.40751929
41MAP3K111.36047244
42TTK1.33413179
43MAP3K141.33182649
44TBK11.32456152
45BRSK11.31741579
46KSR21.31389546
47EIF2AK31.29771287
48CDK81.29762186
49TLK11.29729099
50KIT1.29728148
51CDC42BPA1.29183866
52SIK31.26936098
53TXK1.24590084
54BRSK21.21371129
55CDK71.19049353
56PLK31.18754272
57JAK21.16503359
58NME21.12456174
59MARK21.12368115
60CSF1R1.10405791
61PAK41.04482326
62STK101.03960093
63SMG11.02758092
64BTK0.99865407
65BLK0.97625854
66DYRK30.97402794
67ZAP700.96301020
68CHEK20.95701003
69DAPK10.94856351
70CDK190.93447613
71RPS6KB20.91230560
72DYRK1B0.90491229
73AKT30.90344116
74TGFBR10.90294844
75CHEK10.90135712
76AURKB0.89084781
77SYK0.88969036
78TAOK10.88577168
79TGFBR20.85841945
80IRAK40.85328562
81CDK120.83307740
82EEF2K0.82908899
83JAK10.81479259
84PRKD20.81081151
85FLT30.79938943
86MARK30.79133364
87AURKA0.77048805
88MAPK150.76491460
89PTK60.72521964
90MAP3K10.71936051
91NTRK20.71650075
92MAPK120.71158627
93BRD40.69465168
94MAPK130.68497642
95SIK10.67486724
96MAP3K30.67467675
97TEC0.66782825
98CDK40.66729887
99CLK10.66316632
100ADRBK20.64944695
101KDR0.64402923
102PIM20.63266477
103TESK10.62946016
104IKBKB0.61829965
105PDK20.61494549
106FGFR40.60936151
107NEK10.60468750
108PAK10.60284948
109RET0.59218524
110GRK60.59009006
111PDK10.58948962
112TESK20.58764661
113BRAF0.57599978
114NME10.57493835
115RPS6KL10.57117325
116RPS6KC10.57117325
117FYN0.55894657
118YES10.55822840
119BMPR1B0.55623812
120PIM10.55451626
121LYN0.55270092
122CAMKK10.54244796
123PAK60.53691829
124LCK0.52957994
125CDK20.52880858
126MAP3K100.52596405
127IRAK20.51843288
128CSNK2A10.51785489
129EIF2AK20.50735485
130SCYL20.50501510
131CAMK40.50413764
132MAP3K60.50354987
133JAK30.50225788
134RIPK40.50119345
135PRKD10.50058762
136EPHA20.50017908
137CASK0.49365211
138LRRK20.49079107
139PRKCH0.48579960
140ICK0.48322765
141CSNK2A20.47882256
142DYRK20.47179019
143HIPK20.47139849
144ATM0.45704883
145EPHA40.45298833
146MAPK70.43665699
147MAP3K70.43045053
148NUAK10.42469972
149RPS6KA60.42088223
150MAP3K50.41319001
151MATK0.39583947
152MAP2K60.39460725
153WNK10.39180516
154FGFR30.38407080
155MAPKAPK20.38272301
156DYRK1A0.37725115
157TAOK20.37094094
158PDPK10.36951851
159MAP3K80.36892016
160IRAK10.36793307
161RAF10.36547540
162MAPK40.36164243
163PRKD30.35694365
164PLK20.35673881
165GRK70.35156008
166CAMKK20.34888396
167MUSK0.34606919
168UHMK10.34468947
169MELK0.34117462

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.72758327
2Mismatch repair_Homo sapiens_hsa034303.14463012
3Proteasome_Homo sapiens_hsa030503.04111678
4RNA polymerase_Homo sapiens_hsa030203.00457387
5Ribosome_Homo sapiens_hsa030102.85016746
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78425707
7Base excision repair_Homo sapiens_hsa034102.72128969
8Spliceosome_Homo sapiens_hsa030402.70511547
9Homologous recombination_Homo sapiens_hsa034402.62126025
10Osteoclast differentiation_Homo sapiens_hsa043802.58025083
11RNA transport_Homo sapiens_hsa030132.57294015
12Non-homologous end-joining_Homo sapiens_hsa034502.51569613
13Other glycan degradation_Homo sapiens_hsa005112.35737680
14Basal transcription factors_Homo sapiens_hsa030222.12874106
15Nucleotide excision repair_Homo sapiens_hsa034202.11115062
16Cell cycle_Homo sapiens_hsa041102.10224281
17Staphylococcus aureus infection_Homo sapiens_hsa051502.04237990
18Pyrimidine metabolism_Homo sapiens_hsa002402.00466494
19Tuberculosis_Homo sapiens_hsa051521.94657413
20Autoimmune thyroid disease_Homo sapiens_hsa053201.89620272
21Fanconi anemia pathway_Homo sapiens_hsa034601.88903074
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77364526
23RNA degradation_Homo sapiens_hsa030181.76283072
24Primary immunodeficiency_Homo sapiens_hsa053401.74999398
25Asthma_Homo sapiens_hsa053101.56120610
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49421478
27Purine metabolism_Homo sapiens_hsa002301.49005545
28Non-small cell lung cancer_Homo sapiens_hsa052231.45136655
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41319568
30mRNA surveillance pathway_Homo sapiens_hsa030151.37699184
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32098134
32Type I diabetes mellitus_Homo sapiens_hsa049401.28577665
33Toxoplasmosis_Homo sapiens_hsa051451.27103679
34VEGF signaling pathway_Homo sapiens_hsa043701.26993988
35Epstein-Barr virus infection_Homo sapiens_hsa051691.25247188
36Malaria_Homo sapiens_hsa051441.19918728
37Oocyte meiosis_Homo sapiens_hsa041141.19648072
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.19433542
39Phototransduction_Homo sapiens_hsa047441.18892979
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.17477572
41Antigen processing and presentation_Homo sapiens_hsa046121.17351695
42Chronic myeloid leukemia_Homo sapiens_hsa052201.15766754
43Phagosome_Homo sapiens_hsa041451.14042129
44p53 signaling pathway_Homo sapiens_hsa041151.12789953
45Lysosome_Homo sapiens_hsa041421.11153015
46Pancreatic cancer_Homo sapiens_hsa052121.06464887
47Platelet activation_Homo sapiens_hsa046111.05743535
48Vitamin B6 metabolism_Homo sapiens_hsa007501.03523226
49Pertussis_Homo sapiens_hsa051331.03308524
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.95462302
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.92515966
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92180150
53Herpes simplex infection_Homo sapiens_hsa051680.92163868
54TNF signaling pathway_Homo sapiens_hsa046680.87707168
55Hepatitis C_Homo sapiens_hsa051600.87625058
56Protein export_Homo sapiens_hsa030600.85535077
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83443346
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82851538
59Choline metabolism in cancer_Homo sapiens_hsa052310.82018906
60Prolactin signaling pathway_Homo sapiens_hsa049170.81810467
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81237888
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.81212360
63B cell receptor signaling pathway_Homo sapiens_hsa046620.81201070
64Salmonella infection_Homo sapiens_hsa051320.79134398
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75532821
66Huntingtons disease_Homo sapiens_hsa050160.75425667
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75376240
68Nicotine addiction_Homo sapiens_hsa050330.74673082
69Hematopoietic cell lineage_Homo sapiens_hsa046400.73203659
70Measles_Homo sapiens_hsa051620.72706150
71Glioma_Homo sapiens_hsa052140.70487266
72ErbB signaling pathway_Homo sapiens_hsa040120.68375544
73* mTOR signaling pathway_Homo sapiens_hsa041500.68308443
74Olfactory transduction_Homo sapiens_hsa047400.68165565
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65513460
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65268305
77HTLV-I infection_Homo sapiens_hsa051660.65217623
78Endometrial cancer_Homo sapiens_hsa052130.64996425
79GnRH signaling pathway_Homo sapiens_hsa049120.64859990
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64815869
81African trypanosomiasis_Homo sapiens_hsa051430.64442795
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63592521
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63483359
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62975038
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59871110
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59727296
87Renal cell carcinoma_Homo sapiens_hsa052110.59661081
88Regulation of autophagy_Homo sapiens_hsa041400.59605687
89One carbon pool by folate_Homo sapiens_hsa006700.57598438
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.57489083
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57388056
92Viral carcinogenesis_Homo sapiens_hsa052030.57382580
93T cell receptor signaling pathway_Homo sapiens_hsa046600.56554448
94Shigellosis_Homo sapiens_hsa051310.56429038
95Amphetamine addiction_Homo sapiens_hsa050310.55312117
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52155318
97Estrogen signaling pathway_Homo sapiens_hsa049150.51086203
98Colorectal cancer_Homo sapiens_hsa052100.49239479
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48851514
100Cholinergic synapse_Homo sapiens_hsa047250.48509223
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48508342
102N-Glycan biosynthesis_Homo sapiens_hsa005100.47019755
103Acute myeloid leukemia_Homo sapiens_hsa052210.46345686
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46314159
105Parkinsons disease_Homo sapiens_hsa050120.45693128
106MAPK signaling pathway_Homo sapiens_hsa040100.45428940
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44831354
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.44139901
109Allograft rejection_Homo sapiens_hsa053300.43474241
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43279828
111Long-term potentiation_Homo sapiens_hsa047200.42616257
112Prion diseases_Homo sapiens_hsa050200.42350715
113Legionellosis_Homo sapiens_hsa051340.41227125
114Calcium signaling pathway_Homo sapiens_hsa040200.40780010
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.40629851
116Pentose phosphate pathway_Homo sapiens_hsa000300.39718565
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39555039
118Influenza A_Homo sapiens_hsa051640.38215324
119Rap1 signaling pathway_Homo sapiens_hsa040150.37920233
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37443586
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35980070
122Oxidative phosphorylation_Homo sapiens_hsa001900.35929200
123Hepatitis B_Homo sapiens_hsa051610.34736395
124Graft-versus-host disease_Homo sapiens_hsa053320.34394167
125Inositol phosphate metabolism_Homo sapiens_hsa005620.34104448
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33355445
127Leishmaniasis_Homo sapiens_hsa051400.33192741
128Alcoholism_Homo sapiens_hsa050340.32735932
129HIF-1 signaling pathway_Homo sapiens_hsa040660.32180532
130Collecting duct acid secretion_Homo sapiens_hsa049660.30929814
131Synaptic vesicle cycle_Homo sapiens_hsa047210.30872774
132Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30645582
133Notch signaling pathway_Homo sapiens_hsa043300.29533807
134Viral myocarditis_Homo sapiens_hsa054160.28548291
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.26896566
136Endocytosis_Homo sapiens_hsa041440.26145465
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.25980074
138Vibrio cholerae infection_Homo sapiens_hsa051100.25567756
139Apoptosis_Homo sapiens_hsa042100.24198656
140Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23998491
141Circadian entrainment_Homo sapiens_hsa047130.23793095
142Wnt signaling pathway_Homo sapiens_hsa043100.23490468
143Rheumatoid arthritis_Homo sapiens_hsa053230.22798890
144RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22621890
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.22528621
146Chemokine signaling pathway_Homo sapiens_hsa040620.22028715
147Fructose and mannose metabolism_Homo sapiens_hsa000510.21542614
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20966891
149Pathways in cancer_Homo sapiens_hsa052000.20896954
150Morphine addiction_Homo sapiens_hsa050320.20698416
151Taste transduction_Homo sapiens_hsa047420.20357877

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