STRBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.86692965
2synaptic vesicle docking involved in exocytosis (GO:0016081)6.29980863
3presynaptic membrane organization (GO:0097090)6.24843729
4neurotransmitter-gated ion channel clustering (GO:0072578)5.97909841
5neuron cell-cell adhesion (GO:0007158)5.92445914
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.85302773
7regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)5.76641839
8postsynaptic membrane organization (GO:0001941)5.74453094
9vocalization behavior (GO:0071625)5.64516220
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60112065
11protein localization to synapse (GO:0035418)5.46161401
12synaptic vesicle exocytosis (GO:0016079)5.39285451
13regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04830647
14glutamate secretion (GO:0014047)5.03780975
15regulation of glutamate receptor signaling pathway (GO:1900449)5.00004540
16regulation of synaptic vesicle exocytosis (GO:2000300)4.97433789
17neuronal action potential propagation (GO:0019227)4.58516803
18neuron-neuron synaptic transmission (GO:0007270)4.56131341
19synaptic transmission, glutamatergic (GO:0035249)4.52773800
20negative regulation of synaptic transmission, GABAergic (GO:0032229)4.47277743
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.43617353
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.31090367
23regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.30512402
24regulation of synaptic vesicle transport (GO:1902803)4.29269152
25response to histamine (GO:0034776)4.28209465
26glutamate receptor signaling pathway (GO:0007215)4.27041659
27positive regulation of synapse maturation (GO:0090129)4.26782404
28cerebellar granule cell differentiation (GO:0021707)4.25229430
29positive regulation of neurotransmitter secretion (GO:0001956)4.22105885
30startle response (GO:0001964)4.06239596
31neurotransmitter secretion (GO:0007269)3.99528016
32regulation of excitatory postsynaptic membrane potential (GO:0060079)3.99282939
33synapsis (GO:0007129)3.95167231
34positive regulation of neurotransmitter transport (GO:0051590)3.95061841
35chromatin remodeling at centromere (GO:0031055)3.90347254
36regulation of postsynaptic membrane potential (GO:0060078)3.89097239
37long-term synaptic potentiation (GO:0060291)3.86621759
38regulation of histone H3-K9 methylation (GO:0051570)3.85267640
39cerebellar Purkinje cell differentiation (GO:0021702)3.84603380
40positive regulation of membrane potential (GO:0045838)3.83759337
41G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.78374879
42DNA unwinding involved in DNA replication (GO:0006268)3.77725673
43positive regulation of synapse assembly (GO:0051965)3.77099750
44CENP-A containing nucleosome assembly (GO:0034080)3.73624800
45centriole replication (GO:0007099)3.72586229
46regulation of synapse maturation (GO:0090128)3.72005187
47mitotic sister chromatid cohesion (GO:0007064)3.71536092
48regulation of synaptic transmission, glutamatergic (GO:0051966)3.71485396
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.71462776
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.70844567
51regulation of neurotransmitter secretion (GO:0046928)3.61259298
52synaptic vesicle maturation (GO:0016188)3.57808467
53negative regulation of dendrite morphogenesis (GO:0050774)3.57361525
54histone exchange (GO:0043486)3.55638472
55nuclear pore complex assembly (GO:0051292)3.53270265
56behavioral response to cocaine (GO:0048148)3.51395285
57gamma-aminobutyric acid transport (GO:0015812)3.47618113
58positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.47088519
59regulation of respiratory system process (GO:0044065)3.46374915
60neuron recognition (GO:0008038)3.44049154
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.41718878
62locomotory exploration behavior (GO:0035641)3.39996504
63DNA strand elongation involved in DNA replication (GO:0006271)3.39302064
64negative regulation of DNA-dependent DNA replication (GO:2000104)3.38971926
65resolution of meiotic recombination intermediates (GO:0000712)3.38441302
66nuclear pore organization (GO:0006999)3.37453824
67negative regulation of dendrite development (GO:2000171)3.32457165
68regulation of centriole replication (GO:0046599)3.32401221
69regulation of DNA endoreduplication (GO:0032875)3.31338516
70positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.30468317
71auditory behavior (GO:0031223)3.29329819
72regulation of meiosis I (GO:0060631)3.29131981
73DNA replication checkpoint (GO:0000076)3.28899882
74microtubule depolymerization (GO:0007019)3.27524640
75DNA double-strand break processing (GO:0000729)3.24004363
76membrane hyperpolarization (GO:0060081)3.23638597
77protein localization to kinetochore (GO:0034501)3.22974324
78regulation of synaptic plasticity (GO:0048167)3.22865997
79neurotransmitter transport (GO:0006836)3.22424732
80regulation of neuronal synaptic plasticity (GO:0048168)3.21964419
81regulation of synapse assembly (GO:0051963)3.21812705
82DNA strand elongation (GO:0022616)3.21613107
83DNA replication-independent nucleosome assembly (GO:0006336)3.21403435
84DNA replication-independent nucleosome organization (GO:0034724)3.21403435
85regulation of long-term neuronal synaptic plasticity (GO:0048169)3.21222173
86membrane depolarization (GO:0051899)3.20573250
87regulation of neurotransmitter transport (GO:0051588)3.20440055
88urinary tract smooth muscle contraction (GO:0014848)3.17985974
89axonal fasciculation (GO:0007413)3.17282351
90synapse assembly (GO:0007416)3.15406957
91serotonin metabolic process (GO:0042428)3.14890383
92somatic diversification of immune receptors via somatic mutation (GO:0002566)3.13562793
93somatic hypermutation of immunoglobulin genes (GO:0016446)3.13562793
94replication fork processing (GO:0031297)3.10546424
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10173011
96sister chromatid segregation (GO:0000819)3.10110621
97long-term memory (GO:0007616)3.09136079
98protein localization to cilium (GO:0061512)3.09130448
99DNA replication initiation (GO:0006270)3.08854223
100transferrin transport (GO:0033572)3.08656237
101behavioral fear response (GO:0001662)3.07720121
102behavioral defense response (GO:0002209)3.07720121
103DNA topological change (GO:0006265)3.06864799
104positive regulation of synaptic transmission (GO:0050806)3.06747673
105centriole assembly (GO:0098534)3.05453753
106synaptic vesicle endocytosis (GO:0048488)3.05263211
107pre-miRNA processing (GO:0031054)3.03944654
108regulation of respiratory gaseous exchange (GO:0043576)3.03687434
109exploration behavior (GO:0035640)3.03058083
110cochlea development (GO:0090102)3.02816548
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02458410
112positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02182298
113sister chromatid cohesion (GO:0007062)3.01910432
114learning (GO:0007612)3.00523518
115DNA replication-dependent nucleosome assembly (GO:0006335)2.99915511
116DNA replication-dependent nucleosome organization (GO:0034723)2.99915511
117proline transport (GO:0015824)2.98708142
118regulation of synaptic transmission, GABAergic (GO:0032228)2.97940456
119fear response (GO:0042596)2.97935383
120membrane depolarization during action potential (GO:0086010)2.97041547
121inositol phosphate catabolic process (GO:0071545)2.96984621
122cell differentiation in hindbrain (GO:0021533)2.96321585
123synaptic transmission (GO:0007268)2.95654759
124kinetochore organization (GO:0051383)2.95405296
125transmission of nerve impulse (GO:0019226)2.94495097
126telomere maintenance via semi-conservative replication (GO:0032201)2.93988343
127mitotic sister chromatid segregation (GO:0000070)2.93350828
128regulation of glutamate secretion (GO:0014048)2.92539591
129mitotic metaphase plate congression (GO:0007080)2.91133621
130ATP-dependent chromatin remodeling (GO:0043044)2.89802725
131mitotic recombination (GO:0006312)2.87528014
132negative regulation of DNA recombination (GO:0045910)2.87258281
133ferric iron transport (GO:0015682)2.86015509
134trivalent inorganic cation transport (GO:0072512)2.86015509
135double-strand break repair via nonhomologous end joining (GO:0006303)2.85755984
136non-recombinational repair (GO:0000726)2.85755984
137regulation of neurotransmitter levels (GO:0001505)2.85610826
138regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85487075
139energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.84258522
140ATP hydrolysis coupled proton transport (GO:0015991)2.84258522
141dendrite development (GO:0016358)2.84125779
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.84032595
143protein localization to chromosome, centromeric region (GO:0071459)2.83567776
144membrane assembly (GO:0071709)2.83391561
145regulation of synapse organization (GO:0050807)2.83145265
146regulation of voltage-gated calcium channel activity (GO:1901385)2.82246365
147DNA synthesis involved in DNA repair (GO:0000731)2.81381291
148regulation of dendritic spine development (GO:0060998)2.80889259
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.79691158
150regulation of translation, ncRNA-mediated (GO:0045974)2.79691158
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79691158
152regulation of centrosome cycle (GO:0046605)2.78973697
153regulation of posttranscriptional gene silencing (GO:0060147)2.78021084
154regulation of gene silencing by miRNA (GO:0060964)2.78021084
155regulation of gene silencing by RNA (GO:0060966)2.78021084
156positive regulation of histone H3-K4 methylation (GO:0051571)2.76497213
157chromosome organization involved in meiosis (GO:0070192)2.75915239
158negative regulation of histone methylation (GO:0031061)2.75563455
159meiotic chromosome segregation (GO:0045132)2.74734011
160establishment of integrated proviral latency (GO:0075713)2.73049186
161axonemal dynein complex assembly (GO:0070286)2.72755108
162microtubule polymerization or depolymerization (GO:0031109)2.70904205
163telomere maintenance via recombination (GO:0000722)2.70823806
164nucleotide-excision repair, DNA gap filling (GO:0006297)2.69667028
165male meiosis I (GO:0007141)2.68185424
166metaphase plate congression (GO:0051310)2.67791834
167regulation of mitotic spindle checkpoint (GO:1903504)2.67324410
168regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67324410
169piRNA metabolic process (GO:0034587)2.67027575
170telomere maintenance via telomerase (GO:0007004)2.66508928
171DNA ligation (GO:0006266)2.66025563
172postreplication repair (GO:0006301)2.63574705
173chromatin assembly or disassembly (GO:0006333)2.63508147
174epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63240282
175reciprocal meiotic recombination (GO:0007131)2.62741785
176reciprocal DNA recombination (GO:0035825)2.62741785
177negative regulation of sister chromatid segregation (GO:0033046)2.60983994
178negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.60983994
179negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.60983994
180negative regulation of mitotic sister chromatid segregation (GO:0033048)2.60983994
181negative regulation of mitotic sister chromatid separation (GO:2000816)2.60983994
182regulation of DNA methylation (GO:0044030)2.60850928
183spindle checkpoint (GO:0031577)2.60809129
184negative regulation of chromosome segregation (GO:0051985)2.59673570
185mitotic nuclear envelope disassembly (GO:0007077)2.59573151
186ribosomal small subunit assembly (GO:0000028)2.57319692
187regulation of chromosome segregation (GO:0051983)2.57218908
188kinetochore assembly (GO:0051382)2.57100518
189mitotic spindle checkpoint (GO:0071174)2.56665374
190protein localization to chromosome (GO:0034502)2.56257383
191regulation of centrosome duplication (GO:0010824)2.55164143
192mitotic chromosome condensation (GO:0007076)2.55109442
193regulation of mitotic sister chromatid segregation (GO:0033047)2.54987065
194regulation of sister chromatid segregation (GO:0033045)2.54987065
195regulation of mitotic sister chromatid separation (GO:0010965)2.54987065
196DNA methylation involved in gamete generation (GO:0043046)2.54901584
197attachment of spindle microtubules to kinetochore (GO:0008608)2.54877760
198single strand break repair (GO:0000012)2.54665958
199translesion synthesis (GO:0019985)2.52760805
200cilium movement (GO:0003341)2.51691208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.93412191
2EZH2_22144423_ChIP-Seq_EOC_Human5.53291839
3GBX2_23144817_ChIP-Seq_PC3_Human4.92234855
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.71558590
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.30481392
6TAF15_26573619_Chip-Seq_HEK293_Human3.11742973
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.04049135
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62117115
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58002159
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57193133
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56542980
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.50702334
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.45091303
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44927293
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.37591604
16REST_21632747_ChIP-Seq_MESCs_Mouse2.33517589
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33424579
18CTBP1_25329375_ChIP-Seq_LNCAP_Human2.33385052
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.31399308
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.31307154
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27408255
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27191016
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.25794456
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.20283705
25FUS_26573619_Chip-Seq_HEK293_Human2.15159740
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14552846
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14519725
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.13444732
29E2F1_21310950_ChIP-Seq_MCF-7_Human2.11369882
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08115224
31P300_19829295_ChIP-Seq_ESCs_Human2.07841078
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.04780785
33EED_16625203_ChIP-ChIP_MESCs_Mouse2.01713877
34SMAD4_21799915_ChIP-Seq_A2780_Human2.01673216
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00736666
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99863570
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99863570
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99009117
39JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98924268
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.93385271
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90077485
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.89569540
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85790031
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.83868990
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.78495587
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78415500
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.75927826
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75371380
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.74085411
50MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73948253
51AR_21572438_ChIP-Seq_LNCaP_Human1.72509028
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.71865301
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.71279785
54RNF2_27304074_Chip-Seq_NSC_Mouse1.70937380
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.66303863
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.65425677
57CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.64513006
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.64202140
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60794874
60ELK1_19687146_ChIP-ChIP_HELA_Human1.59808064
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.59722676
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.58372900
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58294204
64FLI1_27457419_Chip-Seq_LIVER_Mouse1.57978755
65MYC_18940864_ChIP-ChIP_HL60_Human1.57804099
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.57785190
67VDR_22108803_ChIP-Seq_LS180_Human1.57695726
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55441955
69ETS1_20019798_ChIP-Seq_JURKAT_Human1.54850105
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53014967
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52263262
72DROSHA_22980978_ChIP-Seq_HELA_Human1.51002921
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.50151656
74IGF1R_20145208_ChIP-Seq_DFB_Human1.49324874
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49175476
76AR_25329375_ChIP-Seq_VCAP_Human1.49038680
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.48739349
78* STAT3_23295773_ChIP-Seq_U87_Human1.47944244
79* NANOG_18555785_Chip-Seq_ESCs_Mouse1.47432976
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46891971
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46802400
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46035192
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45689296
84* TCF4_23295773_ChIP-Seq_U87_Human1.45438450
85AR_21909140_ChIP-Seq_LNCAP_Human1.44387083
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42380926
87SOX2_16153702_ChIP-ChIP_HESCs_Human1.41524804
88ER_23166858_ChIP-Seq_MCF-7_Human1.41292256
89* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40129952
90EWS_26573619_Chip-Seq_HEK293_Human1.39570941
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.36916388
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36636712
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36200979
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36200979
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36102559
96RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35337631
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33697772
98* E2F1_18555785_Chip-Seq_ESCs_Mouse1.33530640
99FOXP3_21729870_ChIP-Seq_TREG_Human1.33430434
100VDR_23849224_ChIP-Seq_CD4+_Human1.33156743
101* SOX2_21211035_ChIP-Seq_LN229_Gbm1.32440072
102ARNT_22903824_ChIP-Seq_MCF-7_Human1.31316538
103* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31308729
104* P53_22387025_ChIP-Seq_ESCs_Mouse1.29148953
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28768771
106IRF1_19129219_ChIP-ChIP_H3396_Human1.27648018
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27519681
108TTF2_22483619_ChIP-Seq_HELA_Human1.26617944
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25429982
110SOX9_26525672_Chip-Seq_HEART_Mouse1.24427718
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.23866600
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23026333
113THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21550217
114ZNF274_21170338_ChIP-Seq_K562_Hela1.20337842
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20225111
116SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19944004
117GATA1_26923725_Chip-Seq_HPCs_Mouse1.19601827
118* CMYC_18555785_Chip-Seq_ESCs_Mouse1.19369119
119* RUNX2_22187159_ChIP-Seq_PCA_Human1.19155396
120AHR_22903824_ChIP-Seq_MCF-7_Human1.18261981
121* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18076565
122IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17602521
123* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16410384
124RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16028282
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15204734
126P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14454457
127FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14395267
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13494825
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.12466554
130* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12450444
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12191234
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12189152
133JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11977494
134JUN_21703547_ChIP-Seq_K562_Human1.11437778
135MYC_18358816_ChIP-ChIP_MESCs_Mouse1.10702905
136YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08798295
137* SOX2_18555785_Chip-Seq_ESCs_Mouse1.08791018
138* P300_18555785_Chip-Seq_ESCs_Mouse1.08790350
139* STAT3_18555785_Chip-Seq_ESCs_Mouse1.07868675
140NFE2_27457419_Chip-Seq_LIVER_Mouse1.07552261
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07306438
142TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06534348
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06406998
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02655389
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01116784
146XRN2_22483619_ChIP-Seq_HELA_Human1.01070598
147NANOG_16153702_ChIP-ChIP_HESCs_Human1.00212122
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99435770
149CBP_20019798_ChIP-Seq_JUKART_Human0.99435770
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99398136
151KDM5A_27292631_Chip-Seq_BREAST_Human0.99253594
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96263417
153NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94264765
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91450731
155ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90504259
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89298286
157MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.88708796
158TP53_22573176_ChIP-Seq_HFKS_Human0.88610383
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88507970
160GABP_19822575_ChIP-Seq_HepG2_Human0.87419479
161E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84085989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.64433546
2MP0004859_abnormal_synaptic_plasticity4.37762812
3MP0008057_abnormal_DNA_replication3.74004467
4MP0003635_abnormal_synaptic_transmissio3.57899555
5MP0009046_muscle_twitch3.33628274
6MP0009745_abnormal_behavioral_response3.27378558
7MP0010094_abnormal_chromosome_stability3.20756367
8MP0001968_abnormal_touch/_nociception3.19741672
9MP0003693_abnormal_embryo_hatching3.17905045
10MP0003787_abnormal_imprinting3.10561539
11MP0004270_analgesia3.08367959
12MP0002063_abnormal_learning/memory/cond3.00862058
13MP0002064_seizures2.97853214
14MP0002572_abnormal_emotion/affect_behav2.84235581
15MP0008058_abnormal_DNA_repair2.80748857
16MP0002736_abnormal_nociception_after2.70999213
17MP0001188_hyperpigmentation2.48317330
18MP0001486_abnormal_startle_reflex2.47102102
19MP0002272_abnormal_nervous_system2.46581149
20MP0002734_abnormal_mechanical_nocicepti2.39112592
21MP0005646_abnormal_pituitary_gland2.30030445
22MP0003879_abnormal_hair_cell2.27317357
23MP0002735_abnormal_chemical_nociception2.27265128
24MP0004957_abnormal_blastocyst_morpholog2.27216604
25MP0003111_abnormal_nucleus_morphology2.27006826
26* MP0002067_abnormal_sensory_capabilities2.20340689
27MP0001984_abnormal_olfaction2.09766714
28MP0003718_maternal_effect2.08298757
29MP0001501_abnormal_sleep_pattern2.07325686
30MP0003077_abnormal_cell_cycle2.02014291
31MP0008877_abnormal_DNA_methylation2.01126484
32MP0006276_abnormal_autonomic_nervous1.98595822
33MP0002876_abnormal_thyroid_physiology1.97642510
34MP0009780_abnormal_chondrocyte_physiolo1.94714692
35MP0005423_abnormal_somatic_nervous1.92470578
36MP0001440_abnormal_grooming_behavior1.89683776
37MP0000778_abnormal_nervous_system1.89478044
38MP0001293_anophthalmia1.83883336
39* MP0002557_abnormal_social/conspecific_i1.74219935
40MP0002184_abnormal_innervation1.71973309
41MP0005386_behavior/neurological_phenoty1.67118781
42MP0004924_abnormal_behavior1.67118781
43MP0003122_maternal_imprinting1.62634669
44MP0008569_lethality_at_weaning1.62515847
45MP0001529_abnormal_vocalization1.59166273
46MP0001970_abnormal_pain_threshold1.57556626
47MP0002733_abnormal_thermal_nociception1.54229087
48* MP0002210_abnormal_sex_determination1.51326877
49MP0002822_catalepsy1.50524734
50MP0006292_abnormal_olfactory_placode1.49189986
51* MP0001929_abnormal_gametogenesis1.47959507
52MP0005551_abnormal_eye_electrophysiolog1.47071825
53MP0008932_abnormal_embryonic_tissue1.46124548
54MP0008995_early_reproductive_senescence1.42630753
55MP0004811_abnormal_neuron_physiology1.40181941
56MP0005645_abnormal_hypothalamus_physiol1.39559459
57MP0003937_abnormal_limbs/digits/tail_de1.37479068
58MP0003121_genomic_imprinting1.33339194
59MP0005499_abnormal_olfactory_system1.31791209
60MP0005394_taste/olfaction_phenotype1.31791209
61MP0004142_abnormal_muscle_tone1.30000335
62MP0002882_abnormal_neuron_morphology1.29685522
63MP0001502_abnormal_circadian_rhythm1.25865357
64MP0003567_abnormal_fetal_cardiomyocyte1.25830074
65MP0000631_abnormal_neuroendocrine_gland1.24462296
66* MP0001145_abnormal_male_reproductive1.23622559
67* MP0002066_abnormal_motor_capabilities/c1.22257264
68MP0001963_abnormal_hearing_physiology1.21919949
69MP0001905_abnormal_dopamine_level1.20004182
70MP0002938_white_spotting1.19824989
71* MP0000653_abnormal_sex_gland1.17040734
72MP0000955_abnormal_spinal_cord1.16935737
73MP0009379_abnormal_foot_pigmentation1.14868506
74MP0005171_absent_coat_pigmentation1.12358583
75MP0001286_abnormal_eye_development1.11047961
76MP0009672_abnormal_birth_weight1.10630563
77MP0010386_abnormal_urinary_bladder1.07317951
78MP0002084_abnormal_developmental_patter1.07087553
79MP0008007_abnormal_cellular_replicative1.06436402
80* MP0002152_abnormal_brain_morphology1.06126454
81MP0002653_abnormal_ependyma_morphology1.05928820
82MP0003183_abnormal_peptide_metabolism1.05215386
83MP0004147_increased_porphyrin_level1.03862297
84MP0004742_abnormal_vestibular_system1.01218853
85MP0003119_abnormal_digestive_system1.00315031
86MP0001485_abnormal_pinna_reflex0.99729803
87MP0000350_abnormal_cell_proliferation0.99650364
88MP0010307_abnormal_tumor_latency0.99036121
89MP0001730_embryonic_growth_arrest0.98842087
90MP0002085_abnormal_embryonic_tissue0.98789085
91MP0001672_abnormal_embryogenesis/_devel0.98387139
92MP0005380_embryogenesis_phenotype0.98387139
93MP0002009_preneoplasia0.97039608
94MP0002233_abnormal_nose_morphology0.97025556
95MP0009697_abnormal_copulation0.96301054
96MP0000026_abnormal_inner_ear0.94978884
97MP0001697_abnormal_embryo_size0.94942637
98MP0009703_decreased_birth_body0.94206448
99MP0004885_abnormal_endolymph0.92181187
100MP0003633_abnormal_nervous_system0.91830703
101MP0004133_heterotaxia0.90596402
102MP0002752_abnormal_somatic_nervous0.90302054
103MP0005409_darkened_coat_color0.89161089
104MP0002909_abnormal_adrenal_gland0.88770503
105MP0002229_neurodegeneration0.88310804
106MP0003786_premature_aging0.88037870
107MP0008789_abnormal_olfactory_epithelium0.87746473
108MP0002697_abnormal_eye_size0.86433953
109* MP0002161_abnormal_fertility/fecundity0.86244285
110MP0003123_paternal_imprinting0.84530526
111MP0008872_abnormal_physiological_respon0.83270697
112MP0006035_abnormal_mitochondrial_morpho0.81985110
113MP0001177_atelectasis0.81621264
114MP0002069_abnormal_eating/drinking_beha0.81178744
115MP0002088_abnormal_embryonic_growth/wei0.80837649
116MP0003631_nervous_system_phenotype0.80827750
117MP0003984_embryonic_growth_retardation0.80335134
118MP0003136_yellow_coat_color0.79828741
119MP0002751_abnormal_autonomic_nervous0.79726104
120MP0005389_reproductive_system_phenotype0.79421656
121MP0001986_abnormal_taste_sensitivity0.78920038
122MP0002160_abnormal_reproductive_system0.78568521
123MP0003941_abnormal_skin_development0.77899160
124MP0003890_abnormal_embryonic-extraembry0.76893955
125* MP0003698_abnormal_male_reproductive0.76566732
126MP0000372_irregular_coat_pigmentation0.76238926
127MP0002837_dystrophic_cardiac_calcinosis0.76152181
128MP0004197_abnormal_fetal_growth/weight/0.75921460
129MP0002638_abnormal_pupillary_reflex0.75621042
130MP0000427_abnormal_hair_cycle0.75182975
131MP0005253_abnormal_eye_physiology0.74781215
132MP0000569_abnormal_digit_pigmentation0.74389559
133MP0000566_synostosis0.73384198
134MP0006072_abnormal_retinal_apoptosis0.72661916
135MP0001664_abnormal_digestion0.71164162
136MP0004085_abnormal_heartbeat0.69192947
137MP0002102_abnormal_ear_morphology0.67803476
138MP0003861_abnormal_nervous_system0.67448940
139MP0004043_abnormal_pH_regulation0.67267085
140MP0000015_abnormal_ear_pigmentation0.65212547
141* MP0010770_preweaning_lethality0.64025270
142* MP0002082_postnatal_lethality0.64025270
143MP0001943_abnormal_respiration0.63076274
144MP0008874_decreased_physiological_sensi0.60771796
145* MP0010769_abnormal_survival0.59776701
146MP0003938_abnormal_ear_development0.59310497
147* MP0010768_mortality/aging0.58237786
148MP0004215_abnormal_myocardial_fiber0.57780913

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.29211957
2Epileptic encephalopathy (HP:0200134)6.08582444
3Febrile seizures (HP:0002373)5.85977248
4Hyperventilation (HP:0002883)5.77591203
5Atonic seizures (HP:0010819)5.68797269
6Focal seizures (HP:0007359)4.81861499
7Broad-based gait (HP:0002136)4.15694332
8Absence seizures (HP:0002121)4.11224248
9Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00277998
10Chromsome breakage (HP:0040012)3.96251543
11Protruding tongue (HP:0010808)3.81708409
12Progressive cerebellar ataxia (HP:0002073)3.80300874
13Dialeptic seizures (HP:0011146)3.79439711
14Gaze-evoked nystagmus (HP:0000640)3.72562135
15Abnormal hair whorl (HP:0010721)3.72151265
16Myokymia (HP:0002411)3.38159906
17Volvulus (HP:0002580)3.32232723
18Gait imbalance (HP:0002141)3.27530685
19Medial flaring of the eyebrow (HP:0010747)3.26795453
20Excessive salivation (HP:0003781)3.21461320
21Drooling (HP:0002307)3.21461320
22Generalized tonic-clonic seizures (HP:0002069)3.19939619
23Absent/shortened dynein arms (HP:0200106)3.09183799
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.09183799
25Congenital primary aphakia (HP:0007707)3.05923423
26Nephrogenic diabetes insipidus (HP:0009806)3.03239742
27Aplasia/Hypoplasia of the uvula (HP:0010293)2.96597547
28Colon cancer (HP:0003003)2.96014740
29Abnormality of chromosome stability (HP:0003220)2.89717069
30Visual hallucinations (HP:0002367)2.88433915
31Abnormal ciliary motility (HP:0012262)2.87059891
32Meckel diverticulum (HP:0002245)2.79770972
33Absent speech (HP:0001344)2.79083076
34Epileptiform EEG discharges (HP:0011182)2.76874968
35Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76326294
36Abnormality of the ileum (HP:0001549)2.76236731
37Abnormal respiratory motile cilium physiology (HP:0012261)2.72250269
38Septo-optic dysplasia (HP:0100842)2.70093191
39Amblyopia (HP:0000646)2.59882466
40Poor eye contact (HP:0000817)2.59752625
41Dysmetric saccades (HP:0000641)2.57988653
42Reticulocytopenia (HP:0001896)2.57622471
43Impaired vibration sensation in the lower limbs (HP:0002166)2.56481661
44Truncal ataxia (HP:0002078)2.56327519
45Abnormality of the preputium (HP:0100587)2.52851067
46Genetic anticipation (HP:0003743)2.52610796
47Inability to walk (HP:0002540)2.51713411
48Chronic bronchitis (HP:0004469)2.50062297
49Fair hair (HP:0002286)2.49989663
50Impaired smooth pursuit (HP:0007772)2.49358477
51Poor coordination (HP:0002370)2.47828057
52Abnormality of the labia minora (HP:0012880)2.44464628
53Blue irides (HP:0000635)2.43580409
54Rhabdomyosarcoma (HP:0002859)2.42706272
55Birth length less than 3rd percentile (HP:0003561)2.41231220
56Abnormal respiratory epithelium morphology (HP:0012253)2.40006440
57Abnormal respiratory motile cilium morphology (HP:0005938)2.40006440
58Chronic hepatic failure (HP:0100626)2.35490051
59EEG with generalized epileptiform discharges (HP:0011198)2.35119808
60Nephroblastoma (Wilms tumor) (HP:0002667)2.32477871
61Polyphagia (HP:0002591)2.31705249
62Dysdiadochokinesis (HP:0002075)2.31629042
63Genital tract atresia (HP:0001827)2.31290105
64Oligodactyly (hands) (HP:0001180)2.30463154
65Pancreatic cysts (HP:0001737)2.30347679
66Hyperthyroidism (HP:0000836)2.28469443
67Generalized hypopigmentation of hair (HP:0011358)2.27041876
68Duodenal stenosis (HP:0100867)2.25992192
69Small intestinal stenosis (HP:0012848)2.25992192
70Vaginal atresia (HP:0000148)2.25028201
71Abnormal eating behavior (HP:0100738)2.24539245
72Urinary bladder sphincter dysfunction (HP:0002839)2.21675982
73Abnormal social behavior (HP:0012433)2.21590931
74Impaired social interactions (HP:0000735)2.21590931
75Ectopic kidney (HP:0000086)2.19388414
76Abnormality of salivation (HP:0100755)2.18597250
77Embryonal renal neoplasm (HP:0011794)2.17860406
78Abnormal lung lobation (HP:0002101)2.16712552
79Specific learning disability (HP:0001328)2.16344687
80Impaired vibratory sensation (HP:0002495)2.12406194
81Hypsarrhythmia (HP:0002521)2.10478583
82Abnormality of the duodenum (HP:0002246)2.09603270
83Sensory axonal neuropathy (HP:0003390)2.09548254
84Triphalangeal thumb (HP:0001199)2.09133486
85Sloping forehead (HP:0000340)2.08447163
86Fetal akinesia sequence (HP:0001989)2.08069546
87Abnormality of ocular smooth pursuit (HP:0000617)2.07852376
88Medulloblastoma (HP:0002885)2.06343459
89Aplasia/Hypoplasia of the sternum (HP:0006714)2.03970885
90Neoplasm of the adrenal cortex (HP:0100641)2.00299554
91Abnormality of the carotid arteries (HP:0005344)1.99821503
92Tubulointerstitial nephritis (HP:0001970)1.98971810
93Absent septum pellucidum (HP:0001331)1.96477667
94Scanning speech (HP:0002168)1.95713012
95Abnormality of the lower motor neuron (HP:0002366)1.95408046
96Abnormality of the septum pellucidum (HP:0007375)1.95335099
97Impulsivity (HP:0100710)1.91991641
98Pancreatic fibrosis (HP:0100732)1.91588312
99Optic nerve hypoplasia (HP:0000609)1.91141540
100Horseshoe kidney (HP:0000085)1.91096612
101Gastroesophageal reflux (HP:0002020)1.90937967
102Hepatoblastoma (HP:0002884)1.90726110
103Rhinitis (HP:0012384)1.89358847
104Supernumerary spleens (HP:0009799)1.88913770
105Absent radius (HP:0003974)1.88692534
106Nephronophthisis (HP:0000090)1.87881653
107Patellar aplasia (HP:0006443)1.86808073
108Stereotypic behavior (HP:0000733)1.86642965
109Aplasia involving forearm bones (HP:0009822)1.85291188
110Absent forearm bone (HP:0003953)1.85291188
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84775582
112Progressive inability to walk (HP:0002505)1.84560269
113Abnormality of the renal medulla (HP:0100957)1.84460989
114Thyroid-stimulating hormone excess (HP:0002925)1.83705809
115Bronchiectasis (HP:0002110)1.82708336
116Clubbing of toes (HP:0100760)1.82369150
117Absent eyebrow (HP:0002223)1.81470109
118Sleep apnea (HP:0010535)1.79943647
119Intestinal atresia (HP:0011100)1.79382648
120Glioma (HP:0009733)1.78212948
121Failure to thrive in infancy (HP:0001531)1.77938427
122Diplopia (HP:0000651)1.77821246
123Abnormality of binocular vision (HP:0011514)1.77821246
124Hypothermia (HP:0002045)1.75598889
125Absent thumb (HP:0009777)1.75381126
126Status epilepticus (HP:0002133)1.75371897
127True hermaphroditism (HP:0010459)1.74491574
128Depression (HP:0000716)1.74252818
129Pheochromocytoma (HP:0002666)1.73310999
130Poor suck (HP:0002033)1.73004929
131Abnormality of cells of the erythroid lineage (HP:0012130)1.72899261
132Bilateral microphthalmos (HP:0007633)1.72760523
133Neoplasm of striated muscle (HP:0009728)1.72755116
134Dysmetria (HP:0001310)1.71670332
135Ependymoma (HP:0002888)1.71350424
136Limb dystonia (HP:0002451)1.70833624
137Increased nuchal translucency (HP:0010880)1.70398568
138Abnormality of midbrain morphology (HP:0002418)1.70236429
139Molar tooth sign on MRI (HP:0002419)1.70236429
140Action tremor (HP:0002345)1.70200333
141Insidious onset (HP:0003587)1.69267149
142Termporal pattern (HP:0011008)1.69267149
143Acute necrotizing encephalopathy (HP:0006965)1.68821710
144Preaxial hand polydactyly (HP:0001177)1.68811561
145Progressive macrocephaly (HP:0004481)1.68132643
146Autism (HP:0000717)1.67380840
147Hyperglycinuria (HP:0003108)1.67248429
148Aplasia/Hypoplasia of the patella (HP:0006498)1.67057167
149Esotropia (HP:0000565)1.67034582
150Cortical dysplasia (HP:0002539)1.66568868
151Aplasia/Hypoplasia of the lens (HP:0008063)1.66512358
152Abnormality of the corticospinal tract (HP:0002492)1.66469603
153Limb hypertonia (HP:0002509)1.66075251
154Pendular nystagmus (HP:0012043)1.65976756
155Exotropia (HP:0000577)1.65629949
156Degeneration of the lateral corticospinal tracts (HP:0002314)1.64420946
157Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.64420946
158Astrocytoma (HP:0009592)1.63874027
159Abnormality of the astrocytes (HP:0100707)1.63874027
160Pancreatic islet-cell hyperplasia (HP:0004510)1.63735263
161Abnormal mitochondria in muscle tissue (HP:0008316)1.63432289
162Optic disc pallor (HP:0000543)1.63223876
163Oligodactyly (HP:0012165)1.63104477
164Anencephaly (HP:0002323)1.61839597
165Myelodysplasia (HP:0002863)1.61162527
166Acute lymphatic leukemia (HP:0006721)1.57594093
167Abnormality of cochlea (HP:0000375)1.57459432
168Dandy-Walker malformation (HP:0001305)1.57013307
169Neoplasm of the oral cavity (HP:0100649)1.56692162
170Abnormal number of erythroid precursors (HP:0012131)1.56463948
171High anterior hairline (HP:0009890)1.56278878
172Hyperglycinemia (HP:0002154)1.53712409
173Embryonal neoplasm (HP:0002898)1.53068531
174Labial hypoplasia (HP:0000066)1.50639131
175Hypoplastic female external genitalia (HP:0012815)1.50420077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.50108948
2CDC73.63909558
3MAP2K73.59389749
4MAP3K43.30792536
5NTRK33.28521259
6EPHA43.16943939
7AKT32.99325409
8CDK192.79224062
9TTK2.73349164
10CCNB12.64432627
11PLK42.51649849
12DAPK22.38825023
13PLK22.28324419
14MAP3K122.24649762
15BUB12.20901099
16NUAK12.13620313
17ZAK2.09006647
18MAP3K102.08262779
19DAPK11.95440174
20MST41.91753200
21EIF2AK31.89561905
22MARK11.87182314
23MAP2K41.78172500
24TAF11.74833001
25MAPK131.73112189
26SGK21.72392036
27TSSK61.72249612
28PRPF4B1.64857025
29NEK11.60321275
30WEE11.58737273
31TNIK1.53982759
32OXSR11.53186641
33MINK11.48831002
34NEK21.48105226
35CAMKK21.46076865
36BRSK21.45263067
37VRK11.44306793
38SIK31.42590665
39EIF2AK11.41954915
40ATR1.41550417
41PBK1.39705889
42CHEK21.39677767
43MAP3K91.39252990
44STK161.38782422
45PLK11.38473830
46NTRK21.33387467
47SGK4941.30617405
48SGK2231.30617405
49DYRK21.24450070
50VRK21.21613501
51PNCK1.19292827
52ACVR1B1.18397726
53BMPR21.16853760
54STK391.13258609
55PDK41.11580204
56PDK31.11580204
57MKNK21.08754483
58RIPK41.07530329
59TRIM281.06828730
60ATM1.06115951
61STK38L1.04358201
62SGK31.03848327
63PASK1.01707333
64PRKCG1.01394749
65KSR10.98840614
66CDK30.97012820
67STK30.96893804
68CDK50.93668638
69CSNK1G10.93093562
70YES10.92736782
71CHEK10.92624713
72CAMK2A0.90842030
73GRK50.90691166
74NLK0.90517490
75CAMK2B0.88882619
76BRAF0.87292691
77GRK10.85735392
78AURKB0.85405085
79CAMKK10.81723436
80WNK40.81603124
81STK380.81072898
82ERBB30.80901611
83RPS6KB20.80472975
84CSNK1E0.80209722
85FGFR20.76784883
86SIK20.76499575
87BRSK10.76206710
88CAMK1D0.75042904
89STK240.73003092
90NME10.71739944
91DYRK30.71421409
92SGK10.69309024
93MAP3K60.69302581
94CDK20.69145047
95CDK70.68359949
96PAK60.67941564
97CDK10.67820976
98STK110.67733537
99DYRK1A0.67228821
100UHMK10.65996096
101WNK30.64905089
102INSRR0.62823619
103PRKCI0.62336247
104CDK180.61599793
105PRKDC0.60455145
106PRKCE0.59077111
107AURKA0.58786036
108SRPK10.58003559
109ADRBK10.57626104
110EIF2AK20.56724030
111PTK2B0.55537570
112BCR0.54144561
113MUSK0.54003225
114BMPR1B0.53628114
115LATS10.53529798
116PLK30.53187714
117FRK0.53143562
118CDK150.52895861
119CAMK40.52837233
120MAPK70.52014474
121STK40.50423321
122PINK10.49940565
123ALK0.49893677
124CDK80.49385890
125FES0.49037453
126CSNK2A20.48789645
127CAMK10.48389949
128CDK40.48369718
129PDK20.48356563
130EEF2K0.47948397
131CDK140.47519339
132MAPK150.47410799
133CSNK1G20.45855325
134TNK20.45339116
135CDK11A0.43775147
136ADRBK20.43624715
137GRK70.43208325
138CAMK1G0.40470515
139MKNK10.38886957
140FGR0.37893316
141RPS6KB10.34686022
142CAMK2D0.31867964
143MAPK120.30861725
144NEK60.29547183
145RPS6KA30.28807096
146PRKACA0.28547782
147DAPK30.25642957
148PRKCB0.25100872
149TLK10.24572062
150RPS6KA20.24566106
151PRKG10.23409004
152MAPK100.22937722
153BRD40.22400352
154CAMK2G0.21035661
155PDK10.20944159
156GSK3B0.20268351
157PIK3CA0.20261555
158FER0.19962649

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.98568177
2Synaptic vesicle cycle_Homo sapiens_hsa047214.00207043
3Mismatch repair_Homo sapiens_hsa034303.57255510
4DNA replication_Homo sapiens_hsa030303.55108227
5Non-homologous end-joining_Homo sapiens_hsa034503.45286273
6Homologous recombination_Homo sapiens_hsa034403.18329907
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.08538341
8Fanconi anemia pathway_Homo sapiens_hsa034603.03706352
9Collecting duct acid secretion_Homo sapiens_hsa049662.94750805
10Morphine addiction_Homo sapiens_hsa050322.76058138
11Olfactory transduction_Homo sapiens_hsa047402.72973965
12Long-term potentiation_Homo sapiens_hsa047202.69763611
13Circadian entrainment_Homo sapiens_hsa047132.69211773
14Amphetamine addiction_Homo sapiens_hsa050312.65811980
15GABAergic synapse_Homo sapiens_hsa047272.62418168
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56446208
17Glutamatergic synapse_Homo sapiens_hsa047242.50005399
18RNA transport_Homo sapiens_hsa030132.45179201
19Ribosome_Homo sapiens_hsa030102.39483443
20Taste transduction_Homo sapiens_hsa047422.39376986
21Cell cycle_Homo sapiens_hsa041102.38725734
22Basal transcription factors_Homo sapiens_hsa030222.29261293
23Base excision repair_Homo sapiens_hsa034102.20929487
24Dopaminergic synapse_Homo sapiens_hsa047282.20625550
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.19670468
26Phototransduction_Homo sapiens_hsa047442.19497988
27RNA polymerase_Homo sapiens_hsa030202.14602706
28RNA degradation_Homo sapiens_hsa030182.09482145
29Spliceosome_Homo sapiens_hsa030402.01637172
30Insulin secretion_Homo sapiens_hsa049111.96979062
31Salivary secretion_Homo sapiens_hsa049701.94522699
32Nucleotide excision repair_Homo sapiens_hsa034201.93023665
33One carbon pool by folate_Homo sapiens_hsa006701.90972586
34Serotonergic synapse_Homo sapiens_hsa047261.86576135
35Long-term depression_Homo sapiens_hsa047301.73581775
36Vibrio cholerae infection_Homo sapiens_hsa051101.70808897
37Renin secretion_Homo sapiens_hsa049241.69989534
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65281926
39Calcium signaling pathway_Homo sapiens_hsa040201.61010974
40Protein export_Homo sapiens_hsa030601.57759313
41Cholinergic synapse_Homo sapiens_hsa047251.55082858
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47276510
43Gastric acid secretion_Homo sapiens_hsa049711.44961248
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.44850367
45Oxytocin signaling pathway_Homo sapiens_hsa049211.44438426
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42261611
47Cocaine addiction_Homo sapiens_hsa050301.40590798
48Propanoate metabolism_Homo sapiens_hsa006401.39995696
49Selenocompound metabolism_Homo sapiens_hsa004501.36993755
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35032762
51Steroid biosynthesis_Homo sapiens_hsa001001.31696654
52Proteasome_Homo sapiens_hsa030501.30438690
53Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.25477918
54Oxidative phosphorylation_Homo sapiens_hsa001901.22528568
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21975686
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21229269
57Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14942966
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14420844
59cAMP signaling pathway_Homo sapiens_hsa040241.13086632
60Butanoate metabolism_Homo sapiens_hsa006501.12830068
61Pyrimidine metabolism_Homo sapiens_hsa002401.12257962
62Axon guidance_Homo sapiens_hsa043601.11128026
63ErbB signaling pathway_Homo sapiens_hsa040121.07586936
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04829950
65GnRH signaling pathway_Homo sapiens_hsa049121.03918692
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03875729
67Gap junction_Homo sapiens_hsa045401.01696610
68Purine metabolism_Homo sapiens_hsa002301.01625607
69Circadian rhythm_Homo sapiens_hsa047100.99880897
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97742712
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95074456
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92536034
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89660215
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89442815
75cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89145226
76Melanogenesis_Homo sapiens_hsa049160.88268287
77Type II diabetes mellitus_Homo sapiens_hsa049300.85121111
78Oocyte meiosis_Homo sapiens_hsa041140.84479563
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.82953939
80Estrogen signaling pathway_Homo sapiens_hsa049150.80742981
81Alzheimers disease_Homo sapiens_hsa050100.80710063
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79718357
83Lysine degradation_Homo sapiens_hsa003100.73264276
84Alcoholism_Homo sapiens_hsa050340.72089128
85MAPK signaling pathway_Homo sapiens_hsa040100.71919466
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71367349
87Inositol phosphate metabolism_Homo sapiens_hsa005620.71042132
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.70712117
89Glioma_Homo sapiens_hsa052140.70224239
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.69754818
91Cardiac muscle contraction_Homo sapiens_hsa042600.69643424
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69220918
93Huntingtons disease_Homo sapiens_hsa050160.67893535
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67074822
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66441317
96Wnt signaling pathway_Homo sapiens_hsa043100.66183677
97Caffeine metabolism_Homo sapiens_hsa002320.66075971
98Vitamin B6 metabolism_Homo sapiens_hsa007500.65647966
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63475387
100p53 signaling pathway_Homo sapiens_hsa041150.62642946
101Basal cell carcinoma_Homo sapiens_hsa052170.61435392
102Rheumatoid arthritis_Homo sapiens_hsa053230.60729898
103Systemic lupus erythematosus_Homo sapiens_hsa053220.57784246
104Glucagon signaling pathway_Homo sapiens_hsa049220.57346253
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57022077
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56831656
107Parkinsons disease_Homo sapiens_hsa050120.56647212
108Pancreatic secretion_Homo sapiens_hsa049720.55376827
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55156017
110Hippo signaling pathway_Homo sapiens_hsa043900.54955541
111Ras signaling pathway_Homo sapiens_hsa040140.52607065
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50478858
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49224208
114Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48536835
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48167738
116Nitrogen metabolism_Homo sapiens_hsa009100.47907814
117Pyruvate metabolism_Homo sapiens_hsa006200.45223476
118Linoleic acid metabolism_Homo sapiens_hsa005910.43881795
119Dorso-ventral axis formation_Homo sapiens_hsa043200.43504218
120Folate biosynthesis_Homo sapiens_hsa007900.43354587
121Fatty acid biosynthesis_Homo sapiens_hsa000610.43058556
122Metabolic pathways_Homo sapiens_hsa011000.42851981
123Choline metabolism in cancer_Homo sapiens_hsa052310.42305613
124Endometrial cancer_Homo sapiens_hsa052130.41738725
125Melanoma_Homo sapiens_hsa052180.39087118
126Thyroid hormone synthesis_Homo sapiens_hsa049180.38970116
127Colorectal cancer_Homo sapiens_hsa052100.38023409
128Type I diabetes mellitus_Homo sapiens_hsa049400.37288242
129Ether lipid metabolism_Homo sapiens_hsa005650.35725286
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.34387820
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34197085
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31373479
133Peroxisome_Homo sapiens_hsa041460.31228995
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31029103
135Biosynthesis of amino acids_Homo sapiens_hsa012300.30494031
136Phagosome_Homo sapiens_hsa041450.30488558
137Ovarian steroidogenesis_Homo sapiens_hsa049130.29755794
138Dilated cardiomyopathy_Homo sapiens_hsa054140.28967812
139Vitamin digestion and absorption_Homo sapiens_hsa049770.28649939
140Tight junction_Homo sapiens_hsa045300.28543670
141Fatty acid metabolism_Homo sapiens_hsa012120.27663298
142Rap1 signaling pathway_Homo sapiens_hsa040150.27221794
143Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27067335
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26181321
145beta-Alanine metabolism_Homo sapiens_hsa004100.26023239
146Thyroid cancer_Homo sapiens_hsa052160.24816733
147MicroRNAs in cancer_Homo sapiens_hsa052060.24800201
1482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24540255
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.24441921
150Epstein-Barr virus infection_Homo sapiens_hsa051690.24027192
151Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23790588
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23394433
153Regulation of autophagy_Homo sapiens_hsa041400.23346711
154Retinol metabolism_Homo sapiens_hsa008300.22462471
155Phospholipase D signaling pathway_Homo sapiens_hsa040720.22186976
156Prostate cancer_Homo sapiens_hsa052150.22026197
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.21930417
158Carbon metabolism_Homo sapiens_hsa012000.21619514
159Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.20313435
160African trypanosomiasis_Homo sapiens_hsa051430.18681960
161Insulin signaling pathway_Homo sapiens_hsa049100.18384806
162mRNA surveillance pathway_Homo sapiens_hsa030150.17747923
163Hedgehog signaling pathway_Homo sapiens_hsa043400.16984477
164Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16669859

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