STRC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.11350912
2regulation of DNA endoreduplication (GO:0032875)4.77316856
3behavioral response to nicotine (GO:0035095)4.58289702
4G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.37964455
5fucose catabolic process (GO:0019317)4.35365995
6L-fucose metabolic process (GO:0042354)4.35365995
7L-fucose catabolic process (GO:0042355)4.35365995
8superoxide anion generation (GO:0042554)4.13458682
9cilium or flagellum-dependent cell motility (GO:0001539)4.11084278
10startle response (GO:0001964)4.08753546
11response to pheromone (GO:0019236)3.85895479
12interferon-gamma production (GO:0032609)3.76349742
13DNA damage induced protein phosphorylation (GO:0006975)3.73968506
14righting reflex (GO:0060013)3.63327928
15motile cilium assembly (GO:0044458)3.55864569
16gamma-aminobutyric acid signaling pathway (GO:0007214)3.51123906
17detection of light stimulus involved in sensory perception (GO:0050962)3.45530082
18detection of light stimulus involved in visual perception (GO:0050908)3.45530082
19production of molecular mediator involved in inflammatory response (GO:0002532)3.41616046
20indolalkylamine metabolic process (GO:0006586)3.40755644
21respiratory chain complex IV assembly (GO:0008535)3.35106793
22retinal cone cell development (GO:0046549)3.31292290
23platelet dense granule organization (GO:0060155)3.31130368
24hepatocyte differentiation (GO:0070365)3.28343996
25regulation of memory T cell differentiation (GO:0043380)3.28273231
26piRNA metabolic process (GO:0034587)3.27719849
27mannosylation (GO:0097502)3.27181336
28cell wall macromolecule metabolic process (GO:0044036)3.26840700
29cell wall macromolecule catabolic process (GO:0016998)3.26840700
30DNA double-strand break processing (GO:0000729)3.26774105
31tryptophan catabolic process (GO:0006569)3.26066065
32indole-containing compound catabolic process (GO:0042436)3.26066065
33indolalkylamine catabolic process (GO:0046218)3.26066065
34neurotransmitter-gated ion channel clustering (GO:0072578)3.24420513
35mechanosensory behavior (GO:0007638)3.23057577
36positive regulation of cellular amide metabolic process (GO:0034250)3.21486452
37serotonin receptor signaling pathway (GO:0007210)3.21464309
38water-soluble vitamin biosynthetic process (GO:0042364)3.20548012
39G-protein coupled receptor internalization (GO:0002031)3.14803689
40kynurenine metabolic process (GO:0070189)3.10722381
41regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.09741644
42cytidine deamination (GO:0009972)3.09485110
43cytidine metabolic process (GO:0046087)3.09485110
44cytidine catabolic process (GO:0006216)3.09485110
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08892988
46vitamin transmembrane transport (GO:0035461)3.08862790
47L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08688108
48cellular ketone body metabolic process (GO:0046950)3.06686325
49cytochrome complex assembly (GO:0017004)3.06685642
50regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05973034
51negative regulation of DNA-dependent DNA replication (GO:2000104)3.05828749
52histone H3-K4 trimethylation (GO:0080182)3.04380480
53protein complex biogenesis (GO:0070271)3.03478596
54preassembly of GPI anchor in ER membrane (GO:0016254)3.02925149
55negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02689152
56regulation of synapse maturation (GO:0090128)3.02593999
57axoneme assembly (GO:0035082)3.01537359
58centriole assembly (GO:0098534)2.99914179
59leukocyte aggregation (GO:0070486)2.96830984
60reflex (GO:0060004)2.96137187
61artery development (GO:0060840)2.95366137
62neural tube formation (GO:0001841)2.92753006
63glutamate receptor signaling pathway (GO:0007215)2.92072954
64negative regulation of synaptic transmission, GABAergic (GO:0032229)2.91997314
65ketone body metabolic process (GO:1902224)2.91439887
66auditory behavior (GO:0031223)2.91203095
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.90621441
68polyketide metabolic process (GO:0030638)2.89436303
69doxorubicin metabolic process (GO:0044598)2.89436303
70daunorubicin metabolic process (GO:0044597)2.89436303
71ubiquinone biosynthetic process (GO:0006744)2.88828729
72quinone biosynthetic process (GO:1901663)2.88828729
73negative regulation of telomere maintenance (GO:0032205)2.88776147
74tryptophan metabolic process (GO:0006568)2.87934762
75regulation of activation of Janus kinase activity (GO:0010533)2.86072173
76positive regulation of interleukin-1 secretion (GO:0050716)2.85888561
77proline transport (GO:0015824)2.83280035
78replicative senescence (GO:0090399)2.81896627
79mitochondrial respiratory chain complex assembly (GO:0033108)2.81144599
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.80242772
81gamma-aminobutyric acid transport (GO:0015812)2.78957511
82negative regulation of viral genome replication (GO:0045071)2.78167341
83regulation of rhodopsin mediated signaling pathway (GO:0022400)2.77759882
84regulation of neurotransmitter uptake (GO:0051580)2.77651735
85pseudouridine synthesis (GO:0001522)2.75265398
86protein-cofactor linkage (GO:0018065)2.74738218
87response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.74319210
88response to host immune response (GO:0052572)2.74319210
89meiotic chromosome segregation (GO:0045132)2.74227031
90regulation of fever generation (GO:0031620)2.74179135
91rhodopsin mediated signaling pathway (GO:0016056)2.73708681
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.73227410
93amino acid salvage (GO:0043102)2.73037246
94L-methionine salvage (GO:0071267)2.73037246
95L-methionine biosynthetic process (GO:0071265)2.73037246
96response to host (GO:0075136)2.72986132
97response to host defenses (GO:0052200)2.72986132
98response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72986132
99positive regulation of heat generation (GO:0031652)2.72313749
100mitochondrial respiratory chain complex I assembly (GO:0032981)2.71606389
101NADH dehydrogenase complex assembly (GO:0010257)2.71606389
102mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71606389
103energy homeostasis (GO:0097009)2.71225460
104axonemal dynein complex assembly (GO:0070286)2.70823951
105neuron cell-cell adhesion (GO:0007158)2.68628459
106indole-containing compound metabolic process (GO:0042430)2.68444295
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68229815
108DNA methylation involved in gamete generation (GO:0043046)2.68051783
109sulfate transmembrane transport (GO:1902358)2.67854265
110pyrimidine ribonucleoside catabolic process (GO:0046133)2.67840301
111extracellular regulation of signal transduction (GO:1900115)2.66725809
112extracellular negative regulation of signal transduction (GO:1900116)2.66725809
113negative regulation of mast cell activation (GO:0033004)2.66317498
114sensory perception of smell (GO:0007608)2.66276916
115photoreceptor cell development (GO:0042461)2.65970515
116regulation of cilium movement (GO:0003352)2.63234303
117negative regulation of telomerase activity (GO:0051974)2.61006861
118response to muramyl dipeptide (GO:0032495)2.60974769
119positive regulation of interleukin-1 production (GO:0032732)2.60511333
120neuronal action potential (GO:0019228)2.60095955
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59944277
122RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59944277
123inner ear receptor cell differentiation (GO:0060113)2.59717475
124positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.59678226
125dopamine transport (GO:0015872)2.59499397
126dentate gyrus development (GO:0021542)2.59028418
127neuronal action potential propagation (GO:0019227)2.57559999
128photoreceptor cell maintenance (GO:0045494)2.57099339
129response to peptidoglycan (GO:0032494)2.56486889
130GPI anchor metabolic process (GO:0006505)2.56421172
131behavioral response to ethanol (GO:0048149)2.55858157
132sulfate transport (GO:0008272)2.55465824
133ubiquinone metabolic process (GO:0006743)2.55189302
134synaptic transmission, glutamatergic (GO:0035249)2.53827821
135response to histamine (GO:0034776)2.52492167
136cornea development in camera-type eye (GO:0061303)2.51104119
137inositol phosphate catabolic process (GO:0071545)2.50473793
138cAMP catabolic process (GO:0006198)2.49873698
139mechanoreceptor differentiation (GO:0042490)2.47553830
140glucocorticoid biosynthetic process (GO:0006704)2.47078274
141cilium morphogenesis (GO:0060271)2.46037190
142eye photoreceptor cell development (GO:0042462)2.45679757
143ionotropic glutamate receptor signaling pathway (GO:0035235)2.44650573
144long-term synaptic potentiation (GO:0060291)2.44595539
145protein polyglutamylation (GO:0018095)2.44320978
146adaptation of signaling pathway (GO:0023058)2.44126255
147nephron tubule morphogenesis (GO:0072078)2.42541435
148nephron epithelium morphogenesis (GO:0072088)2.42541435
149amine catabolic process (GO:0009310)2.42447549
150cellular biogenic amine catabolic process (GO:0042402)2.42447549
151regulation of heat generation (GO:0031650)2.42202331
152replication fork processing (GO:0031297)2.41936553
153transmission of nerve impulse (GO:0019226)2.41631744
154protein localization to synapse (GO:0035418)2.41488174
155primary amino compound metabolic process (GO:1901160)2.39636142
156cellular response to ATP (GO:0071318)2.39566271
157* detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38924647
158response to auditory stimulus (GO:0010996)2.38503460
159interleukin-1-mediated signaling pathway (GO:0070498)2.38011546
160S-adenosylmethionine metabolic process (GO:0046500)2.37956854
161epithelial cilium movement (GO:0003351)2.37717157
162cerebellar granule cell differentiation (GO:0021707)2.37669427
163positive regulation of defense response to virus by host (GO:0002230)2.37502809
164DNA demethylation (GO:0080111)2.37105178
165recombinational repair (GO:0000725)2.36998353
166regulation of meiosis I (GO:0060631)2.36130446
167negative regulation of reactive oxygen species metabolic process (GO:2000378)2.35345235
168macrophage chemotaxis (GO:0048246)2.35175782
169cyclic nucleotide catabolic process (GO:0009214)2.35138505
170urinary tract smooth muscle contraction (GO:0014848)2.33983652
171double-strand break repair via homologous recombination (GO:0000724)2.33677037
172mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.33617884
173neuron-neuron synaptic transmission (GO:0007270)2.32593935
174cilium organization (GO:0044782)2.31960040
175regulation of action potential (GO:0098900)2.31692903
176protein localization to cilium (GO:0061512)2.31340209
177sperm motility (GO:0030317)2.30624277
178cilium movement (GO:0003341)2.28405599
179multicellular organism reproduction (GO:0032504)2.28288260
180dendritic cell chemotaxis (GO:0002407)2.26514358
181nonmotile primary cilium assembly (GO:0035058)2.26118655
182oligosaccharide catabolic process (GO:0009313)2.25993861
183regulation of germinal center formation (GO:0002634)2.25744857
184negative regulation of granulocyte differentiation (GO:0030853)2.25666720
185activated T cell proliferation (GO:0050798)2.23192045
186regulation of interleukin-1 secretion (GO:0050704)2.21378536

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.39900594
2ZNF274_21170338_ChIP-Seq_K562_Hela3.94534431
3VDR_22108803_ChIP-Seq_LS180_Human3.21538051
4EZH2_22144423_ChIP-Seq_EOC_Human3.20470864
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.85702025
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56453949
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41178932
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36620919
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28504322
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.13455224
11SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.12335442
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07873208
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.07767544
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.04150301
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.04145467
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.99922859
17NFE2_27457419_Chip-Seq_LIVER_Mouse1.97156474
18CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96646150
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.96327488
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95077255
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.92633986
22P300_19829295_ChIP-Seq_ESCs_Human1.91725260
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90659600
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.86524486
25NANOG_18555785_Chip-Seq_ESCs_Mouse1.83645611
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.83102684
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.82404971
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82324411
29FUS_26573619_Chip-Seq_HEK293_Human1.81781574
30EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.80902449
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79936316
32TP53_22573176_ChIP-Seq_HFKS_Human1.77850033
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.77641396
34DROSHA_22980978_ChIP-Seq_HELA_Human1.77423624
35SMAD4_21799915_ChIP-Seq_A2780_Human1.76697291
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74812640
37STAT3_18555785_Chip-Seq_ESCs_Mouse1.74349492
38P53_22387025_ChIP-Seq_ESCs_Mouse1.73774854
39E2F1_18555785_Chip-Seq_ESCs_Mouse1.73393102
40EZH2_27294783_Chip-Seq_NPCs_Mouse1.71139425
41* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70794778
42AR_21572438_ChIP-Seq_LNCaP_Human1.70737408
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.69534824
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.68706498
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.66518588
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.65287735
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63599722
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63344075
49IGF1R_20145208_ChIP-Seq_DFB_Human1.61830604
50BCAT_22108803_ChIP-Seq_LS180_Human1.61209799
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61033120
52SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60841581
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60368704
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57816717
55EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.57418680
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.56216354
57CBP_20019798_ChIP-Seq_JUKART_Human1.56216354
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55756518
59TAF15_26573619_Chip-Seq_HEK293_Human1.55623258
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.55327603
61NMYC_18555785_Chip-Seq_ESCs_Mouse1.54964520
62P300_18555785_Chip-Seq_ESCs_Mouse1.53159749
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53125062
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53005730
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52932375
66EWS_26573619_Chip-Seq_HEK293_Human1.52778131
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.52019535
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.51767009
69SOX2_18555785_Chip-Seq_ESCs_Mouse1.50594578
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50535216
71ER_23166858_ChIP-Seq_MCF-7_Human1.48304392
72NANOG_19829295_ChIP-Seq_ESCs_Human1.47721635
73SOX2_19829295_ChIP-Seq_ESCs_Human1.47721635
74MYC_18940864_ChIP-ChIP_HL60_Human1.46286605
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44321092
76ZFX_18555785_Chip-Seq_ESCs_Mouse1.43123689
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.42589306
78* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.42300642
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42232894
80RNF2_27304074_Chip-Seq_NSC_Mouse1.41847477
81FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41306783
82FOXA1_25329375_ChIP-Seq_VCAP_Human1.41306783
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.40733624
84* KLF4_18555785_Chip-Seq_ESCs_Mouse1.40543807
85STAT3_23295773_ChIP-Seq_U87_Human1.40326127
86SMAD1_18555785_Chip-Seq_ESCs_Mouse1.39774006
87EZH2_27304074_Chip-Seq_ESCs_Mouse1.38674324
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.38433715
89PU1_27457419_Chip-Seq_LIVER_Mouse1.38222053
90AR_25329375_ChIP-Seq_VCAP_Human1.37840948
91REST_21632747_ChIP-Seq_MESCs_Mouse1.37607107
92EZH2_27294783_Chip-Seq_ESCs_Mouse1.37029761
93KDM2B_26808549_Chip-Seq_REH_Human1.36435057
94VDR_23849224_ChIP-Seq_CD4+_Human1.35963403
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.35731731
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35604887
97CTCF_18555785_Chip-Seq_ESCs_Mouse1.35377248
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33317856
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32676654
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.32095976
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28747138
102TCF4_22108803_ChIP-Seq_LS180_Human1.28250884
103TCF4_23295773_ChIP-Seq_U87_Human1.27417735
104RNF2_18974828_ChIP-Seq_MESCs_Mouse1.26679835
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.26679835
106SMAD3_21741376_ChIP-Seq_EPCs_Human1.26619378
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26337642
108IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26165703
109FOXA1_21572438_ChIP-Seq_LNCaP_Human1.25408603
110GATA3_21878914_ChIP-Seq_MCF-7_Human1.25122909
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23980202
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23771633
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23112957
114NCOR_22424771_ChIP-Seq_293T_Human1.23017384
115* AR_20517297_ChIP-Seq_VCAP_Human1.21739223
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20591938
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20591938
118CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19972564
119SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19315494
120ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18911614
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18883458
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18548426
123SRF_21415370_ChIP-Seq_HL-1_Mouse1.17893780
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17710280
125HOXB7_26014856_ChIP-Seq_BT474_Human1.17436251
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.14653475
127CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13993922
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.13810929
129IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13768706
130IRF1_19129219_ChIP-ChIP_H3396_Human1.13313112
131ELK1_19687146_ChIP-ChIP_HELA_Human1.13227513
132MTF2_20144788_ChIP-Seq_MESCs_Mouse1.12489375
133RUNX2_22187159_ChIP-Seq_PCA_Human1.12168243
134TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12153395
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11894132
136TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10991012
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.10182442
138SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09123080
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08600761
140PRDM14_20953172_ChIP-Seq_ESCs_Human1.08578924
141LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08510122
142NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08188641
143P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07933610
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.06351640
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04761961
146MYC_19829295_ChIP-Seq_ESCs_Human1.02965421
147AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02273951
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01388015
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01042900
150GATA3_26560356_Chip-Seq_TH2_Human1.00472339
151FOXH1_21741376_ChIP-Seq_EPCs_Human0.99953198
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97988046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.50147355
2MP0003878_abnormal_ear_physiology3.50147355
3MP0003879_abnormal_hair_cell3.46749860
4MP0001188_hyperpigmentation3.33517346
5MP0006292_abnormal_olfactory_placode3.32849641
6MP0002822_catalepsy2.97585761
7MP0002735_abnormal_chemical_nociception2.64694636
8MP0002736_abnormal_nociception_after2.60580328
9MP0010386_abnormal_urinary_bladder2.50473022
10MP0003195_calcinosis2.50041907
11MP0005171_absent_coat_pigmentation2.34003501
12MP0001984_abnormal_olfaction2.32182895
13MP0001485_abnormal_pinna_reflex2.29307518
14MP0003136_yellow_coat_color2.26667257
15MP0005257_abnormal_intraocular_pressure2.21173850
16MP0009046_muscle_twitch2.20149764
17* MP0001963_abnormal_hearing_physiology2.09280078
18MP0001968_abnormal_touch/_nociception2.09018469
19MP0002102_abnormal_ear_morphology2.04485969
20MP0001486_abnormal_startle_reflex2.04445183
21* MP0000026_abnormal_inner_ear2.01847984
22MP0003880_abnormal_central_pattern2.01238704
23MP0002837_dystrophic_cardiac_calcinosis1.96156133
24MP0005551_abnormal_eye_electrophysiolog1.94445452
25MP0000372_irregular_coat_pigmentation1.93725180
26MP0005670_abnormal_white_adipose1.91996061
27MP0004147_increased_porphyrin_level1.90177773
28MP0003787_abnormal_imprinting1.89612286
29MP0001502_abnormal_circadian_rhythm1.89390753
30MP0008875_abnormal_xenobiotic_pharmacok1.87092933
31MP0002638_abnormal_pupillary_reflex1.85885233
32MP0004859_abnormal_synaptic_plasticity1.79065351
33MP0000569_abnormal_digit_pigmentation1.76887534
34MP0008877_abnormal_DNA_methylation1.76872954
35MP0005671_abnormal_response_to1.75603065
36MP0004885_abnormal_endolymph1.69857881
37MP0004043_abnormal_pH_regulation1.67987947
38MP0009745_abnormal_behavioral_response1.61001859
39MP0003646_muscle_fatigue1.59242519
40MP0003635_abnormal_synaptic_transmissio1.52606901
41MP0002277_abnormal_respiratory_mucosa1.50523299
42MP0001873_stomach_inflammation1.50024115
43MP0004742_abnormal_vestibular_system1.49440011
44MP0005646_abnormal_pituitary_gland1.49178240
45MP0002272_abnormal_nervous_system1.47285294
46MP0005084_abnormal_gallbladder_morpholo1.41904298
47MP0002572_abnormal_emotion/affect_behav1.41537996
48MP0008260_abnormal_autophagy1.40076200
49MP0002067_abnormal_sensory_capabilities1.39888993
50MP0009785_altered_susceptibility_to1.39058993
51MP0002733_abnormal_thermal_nociception1.37363374
52MP0002148_abnormal_hypersensitivity_rea1.34355849
53MP0002876_abnormal_thyroid_physiology1.34238717
54MP0001501_abnormal_sleep_pattern1.34098832
55MP0001986_abnormal_taste_sensitivity1.33838276
56MP0002063_abnormal_learning/memory/cond1.30535549
57MP0000427_abnormal_hair_cycle1.30014960
58MP0003950_abnormal_plasma_membrane1.29495202
59MP0001905_abnormal_dopamine_level1.26654284
60MP0002138_abnormal_hepatobiliary_system1.26617443
61MP0008004_abnormal_stomach_pH1.25044257
62MP0008058_abnormal_DNA_repair1.23981443
63MP0003183_abnormal_peptide_metabolism1.23012227
64MP0003941_abnormal_skin_development1.20520130
65MP0003724_increased_susceptibility_to1.19956803
66MP0003718_maternal_effect1.19889082
67MP0000566_synostosis1.18435872
68MP0005253_abnormal_eye_physiology1.17364389
69MP0005386_behavior/neurological_phenoty1.15887452
70MP0004924_abnormal_behavior1.15887452
71MP0002064_seizures1.14799654
72MP0002734_abnormal_mechanical_nocicepti1.14311012
73MP0005645_abnormal_hypothalamus_physiol1.12627307
74MP0003137_abnormal_impulse_conducting1.10900474
75MP0000383_abnormal_hair_follicle1.10773588
76MP0000490_abnormal_crypts_of1.09925777
77MP0000015_abnormal_ear_pigmentation1.07586292
78MP0003011_delayed_dark_adaptation1.07541012
79MP0004215_abnormal_myocardial_fiber1.06794538
80MP0001346_abnormal_lacrimal_gland1.06271105
81MP0005389_reproductive_system_phenotype1.05784617
82MP0002938_white_spotting1.05719893
83MP0004145_abnormal_muscle_electrophysio1.05477547
84MP0005423_abnormal_somatic_nervous1.04681160
85MP0002653_abnormal_ependyma_morphology1.04009217
86MP0001919_abnormal_reproductive_system1.03352070
87MP0005167_abnormal_blood-brain_barrier1.03288800
88MP0004782_abnormal_surfactant_physiolog1.02023102
89MP0009764_decreased_sensitivity_to0.99699850
90MP0002419_abnormal_innate_immunity0.98795036
91MP0000678_abnormal_parathyroid_gland0.98428959
92MP0004484_altered_response_of0.98264979
93MP0006072_abnormal_retinal_apoptosis0.97799107
94MP0001790_abnormal_immune_system0.96824454
95MP0005387_immune_system_phenotype0.96824454
96MP0002557_abnormal_social/conspecific_i0.96736817
97MP0002160_abnormal_reproductive_system0.96207132
98MP0002163_abnormal_gland_morphology0.95794618
99MP0004133_heterotaxia0.95405858
100MP0005332_abnormal_amino_acid0.95371202
101MP0002132_abnormal_respiratory_system0.95045684
102MP0005409_darkened_coat_color0.94977758
103MP0002396_abnormal_hematopoietic_system0.94137143
104MP0008057_abnormal_DNA_replication0.93917327
105MP0002184_abnormal_innervation0.91051664
106MP0009697_abnormal_copulation0.91037643
107MP0002928_abnormal_bile_duct0.89264539
108MP0004808_abnormal_hematopoietic_stem0.88288672
109* MP0002752_abnormal_somatic_nervous0.88170240
110MP0003786_premature_aging0.86270775
111MP0002909_abnormal_adrenal_gland0.85074139
112MP0006276_abnormal_autonomic_nervous0.84719659
113MP0002234_abnormal_pharynx_morphology0.84534883
114MP0000230_abnormal_systemic_arterial0.84290073
115MP0003252_abnormal_bile_duct0.83979589
116MP0008995_early_reproductive_senescence0.83813681
117MP0005025_abnormal_response_to0.83475210
118MP0005075_abnormal_melanosome_morpholog0.82560981
119MP0002723_abnormal_immune_serum0.82378839
120MP0005195_abnormal_posterior_eye0.82215610
121MP0001929_abnormal_gametogenesis0.81826943
122MP0002229_neurodegeneration0.81652566
123MP0001764_abnormal_homeostasis0.81529734
124MP0001819_abnormal_immune_cell0.81357654
125MP0001835_abnormal_antigen_presentation0.80730711
126MP0005174_abnormal_tail_pigmentation0.80605817
127MP0002751_abnormal_autonomic_nervous0.80564281
128MP0002420_abnormal_adaptive_immunity0.80453745
129MP0003938_abnormal_ear_development0.80449059
130MP0005000_abnormal_immune_tolerance0.80408305
131MP0002095_abnormal_skin_pigmentation0.79314391
132MP0001529_abnormal_vocalization0.78578116
133MP0000538_abnormal_urinary_bladder0.78209265
134MP0001324_abnormal_eye_pigmentation0.77275743
135MP0001970_abnormal_pain_threshold0.76111961
136MP0004142_abnormal_muscle_tone0.75323327
137MP0003121_genomic_imprinting0.75228179
138MP0001440_abnormal_grooming_behavior0.73819126
139MP0008872_abnormal_physiological_respon0.73301096
140MP0000631_abnormal_neuroendocrine_gland0.71946533
141MP0001800_abnormal_humoral_immune0.69826389
142MP0005379_endocrine/exocrine_gland_phen0.69163948
143MP0001663_abnormal_digestive_system0.68923603
144MP0006082_CNS_inflammation0.68888215
145MP0002452_abnormal_antigen_presenting0.67608253
146MP0003698_abnormal_male_reproductive0.67100500
147MP0005410_abnormal_fertilization0.66026577

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)5.83689349
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.97153047
3Febrile seizures (HP:0002373)4.57573217
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.37206628
5Chromsome breakage (HP:0040012)4.32204121
6Pancreatic cysts (HP:0001737)4.22906772
7Congenital stationary night blindness (HP:0007642)4.05350552
8Abnormality of midbrain morphology (HP:0002418)3.83114806
9Molar tooth sign on MRI (HP:0002419)3.83114806
10Pancreatic fibrosis (HP:0100732)3.74371325
11Absent/shortened dynein arms (HP:0200106)3.50922217
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.50922217
13Focal motor seizures (HP:0011153)3.39541082
14Retrobulbar optic neuritis (HP:0100654)3.37082514
15Optic neuritis (HP:0100653)3.37082514
16Attenuation of retinal blood vessels (HP:0007843)3.35145721
17Abnormality of the preputium (HP:0100587)3.11207360
18Aplasia/Hypoplasia of the uvula (HP:0010293)3.09178946
19Abnormality of the prostate (HP:0008775)3.08746522
20Abnormality of the renal cortex (HP:0011035)3.06907162
21Abnormal ciliary motility (HP:0012262)3.03133933
22Septo-optic dysplasia (HP:0100842)2.99407783
23Abnormal respiratory motile cilium physiology (HP:0012261)2.95953686
24Type II lissencephaly (HP:0007260)2.92450351
25Hypoplasia of the fovea (HP:0007750)2.86075404
26Aplasia/Hypoplasia of the fovea (HP:0008060)2.86075404
27Epileptic encephalopathy (HP:0200134)2.84261718
28Abolished electroretinogram (ERG) (HP:0000550)2.83675178
29Orchitis (HP:0100796)2.83130996
30Abnormal drinking behavior (HP:0030082)2.81636147
31Polydipsia (HP:0001959)2.81636147
32Clubbing of toes (HP:0100760)2.78569625
33Toxemia of pregnancy (HP:0100603)2.71618817
34Meckel diverticulum (HP:0002245)2.70642999
35Tubular atrophy (HP:0000092)2.67134149
36Abnormality of the carotid arteries (HP:0005344)2.66259641
37Chronic mucocutaneous candidiasis (HP:0002728)2.65238537
38Recurrent cutaneous fungal infections (HP:0011370)2.65238537
39Abnormal respiratory epithelium morphology (HP:0012253)2.62034357
40Abnormal respiratory motile cilium morphology (HP:0005938)2.62034357
41Congenital sensorineural hearing impairment (HP:0008527)2.61649981
42Optic nerve hypoplasia (HP:0000609)2.61254901
43Cystic liver disease (HP:0006706)2.59557129
44Protruding tongue (HP:0010808)2.58878904
45Chronic hepatic failure (HP:0100626)2.57344581
46Abnormality of the ileum (HP:0001549)2.53531819
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.51366448
48Mitochondrial inheritance (HP:0001427)2.51111036
49Acute necrotizing encephalopathy (HP:0006965)2.49290317
50Increased CSF lactate (HP:0002490)2.45558698
51Inability to walk (HP:0002540)2.43083811
52Decreased circulating renin level (HP:0003351)2.42438839
53Progressive inability to walk (HP:0002505)2.41135132
54Patchy hypopigmentation of hair (HP:0011365)2.40988829
55Nonprogressive disorder (HP:0003680)2.40841952
56Gaze-evoked nystagmus (HP:0000640)2.39522554
57Pendular nystagmus (HP:0012043)2.38909020
58Medial flaring of the eyebrow (HP:0010747)2.37433918
59Myositis (HP:0100614)2.34388687
60Hyperventilation (HP:0002883)2.33088033
61Lipid accumulation in hepatocytes (HP:0006561)2.32977692
62Progressive macrocephaly (HP:0004481)2.32524952
63Oligodactyly (hands) (HP:0001180)2.31470533
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.30734039
65Small intestinal stenosis (HP:0012848)2.28269806
66Duodenal stenosis (HP:0100867)2.28269806
67White forelock (HP:0002211)2.25435070
68Stomach cancer (HP:0012126)2.25410304
69Hypothermia (HP:0002045)2.25088582
70Acute encephalopathy (HP:0006846)2.24477438
71Severe visual impairment (HP:0001141)2.23589555
72Polyuria (HP:0000103)2.22384846
73Decreased central vision (HP:0007663)2.21983938
74Abnormality of chromosome stability (HP:0003220)2.21834131
75Abnormality of alanine metabolism (HP:0010916)2.19859433
76Hyperalaninemia (HP:0003348)2.19859433
77Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19859433
78Abnormality of the renal collecting system (HP:0004742)2.19041362
79Rhinitis (HP:0012384)2.18232626
80Increased hepatocellular lipid droplets (HP:0006565)2.16091635
81Keratoconus (HP:0000563)2.15630014
82Increased corneal curvature (HP:0100692)2.15630014
83Abnormality of macular pigmentation (HP:0008002)2.15159955
84Large for gestational age (HP:0001520)2.14528578
85Recurrent abscess formation (HP:0002722)2.14229877
86Congenital hepatic fibrosis (HP:0002612)2.13681113
87Cheilitis (HP:0100825)2.11876327
88Hemiparesis (HP:0001269)2.11801623
89Type 2 muscle fiber atrophy (HP:0003554)2.10926650
90Abnormality of DNA repair (HP:0003254)2.10870286
91Congenital primary aphakia (HP:0007707)2.10363118
92Gait imbalance (HP:0002141)2.09677638
93Sclerocornea (HP:0000647)2.09247130
943-Methylglutaconic aciduria (HP:0003535)2.08683887
95Alveolar cell carcinoma (HP:0006519)2.08428377
96Hepatocellular necrosis (HP:0001404)2.08371951
97Abnormality of the labia minora (HP:0012880)2.08321051
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.08231808
99Petechiae (HP:0000967)2.04946210
100Microvesicular hepatic steatosis (HP:0001414)2.04590559
101Nephrogenic diabetes insipidus (HP:0009806)2.04470214
102Congenital, generalized hypertrichosis (HP:0004540)2.04218764
103Abnormal mitochondria in muscle tissue (HP:0008316)2.04055172
104Optic disc pallor (HP:0000543)2.03256284
105Oligomenorrhea (HP:0000876)2.03203825
106Bony spicule pigmentary retinopathy (HP:0007737)2.03098658
107Retinal dysplasia (HP:0007973)2.00865467
108Prolonged bleeding time (HP:0003010)2.00696105
109Recurrent fungal infections (HP:0002841)1.99253245
110Aplasia/Hypoplasia of the tongue (HP:0010295)1.99173132
111Progressive cerebellar ataxia (HP:0002073)1.99036862
112Abnormality of the fovea (HP:0000493)1.98592681
113Duplicated collecting system (HP:0000081)1.98413202
114Methylmalonic acidemia (HP:0002912)1.97255247
115Furrowed tongue (HP:0000221)1.95928210
116Absent speech (HP:0001344)1.95866111
117Lissencephaly (HP:0001339)1.94573426
118Recurrent pneumonia (HP:0006532)1.94471035
119Abnormality of male internal genitalia (HP:0000022)1.94344077
120Cerebellar dysplasia (HP:0007033)1.94293992
121Tubulointerstitial nephritis (HP:0001970)1.94205073
122Hepatic necrosis (HP:0002605)1.94160385
123Broad-based gait (HP:0002136)1.93399033
124Abnormality of the pons (HP:0007361)1.93188867
125Nephronophthisis (HP:0000090)1.92105487
126Hypoproteinemia (HP:0003075)1.89936719
127Progressive microcephaly (HP:0000253)1.89627068
128Eczematoid dermatitis (HP:0000976)1.89427679
129Obstructive lung disease (HP:0006536)1.88736917
130Chronic obstructive pulmonary disease (HP:0006510)1.88736917
131Neoplasm of the tracheobronchial system (HP:0100552)1.88594747
132Hypoplasia of the pons (HP:0012110)1.88587344
133Abnormal biliary tract physiology (HP:0012439)1.88140938
134Bile duct proliferation (HP:0001408)1.88140938
135Renal cortical cysts (HP:0000803)1.88129722
136Anencephaly (HP:0002323)1.87780825
137Increased serum lactate (HP:0002151)1.87403027
138Aplasia/Hypoplasia of the tibia (HP:0005772)1.87116114
139Male pseudohermaphroditism (HP:0000037)1.86827991
140Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.86651234
141Astigmatism (HP:0000483)1.86573213
142Fair hair (HP:0002286)1.86067546
143Chronic diarrhea (HP:0002028)1.85797587
144IgG deficiency (HP:0004315)1.85601694
145Recurrent bacterial skin infections (HP:0005406)1.85452592
146Abnormal albumin level (HP:0012116)1.84607302
147Hypoalbuminemia (HP:0003073)1.84607302
148Abnormality of the duodenum (HP:0002246)1.81943371
149Hypomagnesemia (HP:0002917)1.80696812
150Chorioretinal atrophy (HP:0000533)1.80282173
151Methylmalonic aciduria (HP:0012120)1.79338137
152Thyroiditis (HP:0100646)1.78743255
153Keratoconjunctivitis sicca (HP:0001097)1.78560713
154Mesangial abnormality (HP:0001966)1.78288770
155Severe muscular hypotonia (HP:0006829)1.77462542
156Renal Fanconi syndrome (HP:0001994)1.77319125
157Myelodysplasia (HP:0002863)1.76632379
158Aplasia/hypoplasia of the uterus (HP:0008684)1.76450698
159Genital tract atresia (HP:0001827)1.76051008
160Intestinal atresia (HP:0011100)1.75958293
161Ketoacidosis (HP:0001993)1.75953745
162Focal seizures (HP:0007359)1.75605940
163Abnormal urine output (HP:0012590)1.75342147
164Keratoconjunctivitis (HP:0001096)1.75030522
165Postaxial foot polydactyly (HP:0001830)1.74386724
166Ectopic kidney (HP:0000086)1.73841395
167Poor coordination (HP:0002370)1.73691184
168Mediastinal lymphadenopathy (HP:0100721)1.73231453
169Abnormal hair whorl (HP:0010721)1.72525455
170Abnormal rod and cone electroretinograms (HP:0008323)1.70970298
171Widely spaced teeth (HP:0000687)1.70935601
172True hermaphroditism (HP:0010459)1.70728193
173Meningitis (HP:0001287)1.69510392
174Abnormality of the renal medulla (HP:0100957)1.66924787
175Vasculitis (HP:0002633)1.66489213
176Bone marrow hypocellularity (HP:0005528)1.65651830
177Maternal diabetes (HP:0009800)1.64278142
178Upper limb muscle weakness (HP:0003484)1.64102385

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.19093558
2FRK4.91293956
3CASK4.71912977
4PIK3CA3.99865416
5BMPR1B3.10155854
6MAP4K22.93190473
7TNIK2.85472952
8TXK2.74855378
9EIF2AK22.69022546
10MAP3K142.65443871
11NTRK32.54705747
12MAP2K72.43080600
13RIPK42.31050758
14WNK32.22646545
15WNK42.21990689
16PINK12.15594439
17TRIM282.07514848
18TAOK22.02634474
19TLK12.00056012
20ACVR1B1.91770122
21YES11.89185141
22ZAK1.85935642
23DAPK21.79261198
24SIK31.68742426
25CDK121.55031389
26MST41.47456657
27OXSR11.47344061
28TAOK31.46802851
29IRAK41.46169154
30CDK31.45788106
31MAP3K131.45510597
32IRAK31.43116934
33GRK11.38335843
34BCKDK1.33490780
35CDK91.33044022
36MAP3K21.32970078
37STK391.32804435
38STK38L1.32243077
39PRPF4B1.28576699
40ADRBK21.28275422
41NME11.22908855
42TRPM71.22219676
43TNK21.20335681
44EIF2AK31.17680192
45MAP3K41.12482367
46KSR21.11866946
47MAPK131.10951686
48MAPK151.03891464
49AKT31.03372046
50PAK31.02756436
51EPHA41.02623395
52FES1.01670709
53PHKG20.99387431
54PHKG10.99387431
55PLK30.98263496
56TGFBR10.98184326
57MET0.97975470
58SGK20.97647248
59MUSK0.97348566
60MAP2K60.94613900
61CSNK1G20.94507709
62BMPR20.94216771
63BCR0.94209378
64NUAK10.94207489
65CDK80.93159774
66CSNK1G30.93081663
67CSNK1G10.91641354
68ERBB30.91226421
69INSRR0.89471637
70MARK10.86052555
71ADRBK10.83688047
72MAP3K70.80190336
73MAP3K60.78529493
74CSNK1A1L0.78057462
75MAPKAPK30.76079197
76IKBKE0.75038483
77MKNK20.74879034
78ITK0.74840766
79NTRK20.74825468
80STK160.74688234
81PBK0.73119477
82NEK60.72012210
83NLK0.71936346
84PTK2B0.70656513
85DYRK20.68670100
86ATR0.68345299
87CAMK2D0.66837989
88MKNK10.66232582
89FGFR20.65156162
90VRK20.65041788
91TIE10.64028532
92LYN0.62633232
93KIT0.61772196
94CCNB10.61039626
95BUB10.60789648
96IRAK10.59870267
97TEC0.59744188
98PLK20.58424731
99FER0.58201740
100CHUK0.57594382
101GRK50.57555677
102JAK10.57269701
103SGK10.56724113
104CAMK10.56292275
105PRKCE0.55877397
106SGK2230.55595153
107SGK4940.55595153
108PRKCI0.53985879
109DAPK10.52465519
110MINK10.52197758
111PAK60.51216806
112SYK0.47475478
113PRKCQ0.47274197
114BTK0.47137303
115JAK30.46208644
116CAMKK20.46135008
117IKBKB0.45901606
118PLK40.44682195
119CAMK2A0.44627467
120SGK30.44555946
121MAPK70.44387164
122TSSK60.44343561
123STK380.44309652
124CSNK1A10.42918642
125CHEK20.42730328
126MAP2K10.42461408
127CAMK40.42328636
128MAP2K40.42077887
129CAMK1G0.41676396
130WEE10.41614081
131RPS6KA50.41097328
132PRKD20.39949915
133CSNK1D0.39544630
134KDR0.39105903
135FLT30.38549657
136PRKCG0.38278732
137MAPK120.37706841
138MARK30.37062593
139HCK0.36249787
140PRKCA0.34920238
141PLK10.34606287
142MAPKAPK50.34589178
143GRK70.34480463
144PKN10.34436414
145MAP2K20.34015010
146BRSK20.33851648
147JAK20.33373634
148MAP3K10.31290292
149VRK10.30080472
150PRKAA20.29242355
151MAP3K120.28774896
152MARK20.26821612
153LCK0.26421278
154PRKACA0.25179269
155SRPK10.25048831
156CAMK2B0.24929305

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.79904748
2Fanconi anemia pathway_Homo sapiens_hsa034602.34110408
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28337359
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23171134
5Nitrogen metabolism_Homo sapiens_hsa009102.22337283
6Morphine addiction_Homo sapiens_hsa050322.20149625
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10606510
8Olfactory transduction_Homo sapiens_hsa047402.05852958
9Oxidative phosphorylation_Homo sapiens_hsa001902.04621357
10Linoleic acid metabolism_Homo sapiens_hsa005912.04002766
11Butanoate metabolism_Homo sapiens_hsa006502.03790067
12RNA polymerase_Homo sapiens_hsa030202.02080617
13Protein export_Homo sapiens_hsa030602.01196007
14Selenocompound metabolism_Homo sapiens_hsa004501.99526496
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99156566
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.99098737
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95880308
18Proteasome_Homo sapiens_hsa030501.93718514
19Circadian entrainment_Homo sapiens_hsa047131.81915160
20Mineral absorption_Homo sapiens_hsa049781.74473658
21Leishmaniasis_Homo sapiens_hsa051401.67300565
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64862876
23Caffeine metabolism_Homo sapiens_hsa002321.62828206
24Taste transduction_Homo sapiens_hsa047421.59487082
25Graft-versus-host disease_Homo sapiens_hsa053321.57403857
26Parkinsons disease_Homo sapiens_hsa050121.56411852
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.54241469
28Ether lipid metabolism_Homo sapiens_hsa005651.54088767
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.54085493
30Salivary secretion_Homo sapiens_hsa049701.52176521
31Glutamatergic synapse_Homo sapiens_hsa047241.51796371
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49719699
33Tryptophan metabolism_Homo sapiens_hsa003801.49386264
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.47481188
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44223185
36GABAergic synapse_Homo sapiens_hsa047271.41553514
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40341958
38Serotonergic synapse_Homo sapiens_hsa047261.37521279
39Synaptic vesicle cycle_Homo sapiens_hsa047211.36561412
40Hematopoietic cell lineage_Homo sapiens_hsa046401.35127365
41Rheumatoid arthritis_Homo sapiens_hsa053231.31131971
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30991656
43Propanoate metabolism_Homo sapiens_hsa006401.30934763
44Calcium signaling pathway_Homo sapiens_hsa040201.28039785
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26864957
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25221049
47RNA degradation_Homo sapiens_hsa030181.24631843
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.23270450
49One carbon pool by folate_Homo sapiens_hsa006701.21609587
50Autoimmune thyroid disease_Homo sapiens_hsa053201.15733179
51Allograft rejection_Homo sapiens_hsa053301.15504114
52Asthma_Homo sapiens_hsa053101.15116640
53NF-kappa B signaling pathway_Homo sapiens_hsa040641.13614694
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.13068861
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12812461
56Peroxisome_Homo sapiens_hsa041461.12500137
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12381458
58Collecting duct acid secretion_Homo sapiens_hsa049661.11815988
59Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11750147
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10589767
61Homologous recombination_Homo sapiens_hsa034401.10199821
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.08826309
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07242262
64Type I diabetes mellitus_Homo sapiens_hsa049401.02551124
65Phototransduction_Homo sapiens_hsa047441.01252436
66Measles_Homo sapiens_hsa051620.99672588
67African trypanosomiasis_Homo sapiens_hsa051430.96555016
68Huntingtons disease_Homo sapiens_hsa050160.94333587
69Dorso-ventral axis formation_Homo sapiens_hsa043200.94318409
70Alzheimers disease_Homo sapiens_hsa050100.93881141
71Osteoclast differentiation_Homo sapiens_hsa043800.91799876
72Chemical carcinogenesis_Homo sapiens_hsa052040.91640853
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90657569
74TNF signaling pathway_Homo sapiens_hsa046680.90488999
75Influenza A_Homo sapiens_hsa051640.88496544
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.88038005
77Insulin secretion_Homo sapiens_hsa049110.86790419
78cAMP signaling pathway_Homo sapiens_hsa040240.85736655
79Long-term potentiation_Homo sapiens_hsa047200.85710691
80Sulfur metabolism_Homo sapiens_hsa009200.85703720
81Primary immunodeficiency_Homo sapiens_hsa053400.84283730
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84145077
83Herpes simplex infection_Homo sapiens_hsa051680.83639258
84Other glycan degradation_Homo sapiens_hsa005110.81779351
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.80744376
86Long-term depression_Homo sapiens_hsa047300.78782679
87Amphetamine addiction_Homo sapiens_hsa050310.78501773
88Chemokine signaling pathway_Homo sapiens_hsa040620.78407901
89Arachidonic acid metabolism_Homo sapiens_hsa005900.77014035
90Circadian rhythm_Homo sapiens_hsa047100.76954278
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76639388
92Inositol phosphate metabolism_Homo sapiens_hsa005620.76413058
93Cholinergic synapse_Homo sapiens_hsa047250.76227433
94Ovarian steroidogenesis_Homo sapiens_hsa049130.75977509
95Sphingolipid metabolism_Homo sapiens_hsa006000.75936562
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75541780
97Cocaine addiction_Homo sapiens_hsa050300.75513412
98Cardiac muscle contraction_Homo sapiens_hsa042600.74892591
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.73181526
100Retinol metabolism_Homo sapiens_hsa008300.73041191
101Vitamin B6 metabolism_Homo sapiens_hsa007500.72254491
102ErbB signaling pathway_Homo sapiens_hsa040120.71056867
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70972465
104ABC transporters_Homo sapiens_hsa020100.70520391
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70487728
106Type II diabetes mellitus_Homo sapiens_hsa049300.69849697
107Malaria_Homo sapiens_hsa051440.67819737
108Pyrimidine metabolism_Homo sapiens_hsa002400.66278896
109Tuberculosis_Homo sapiens_hsa051520.65720569
110Fatty acid elongation_Homo sapiens_hsa000620.64519244
111Pertussis_Homo sapiens_hsa051330.63808987
112Non-homologous end-joining_Homo sapiens_hsa034500.63661616
113Renin secretion_Homo sapiens_hsa049240.63363303
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61914774
115Metabolic pathways_Homo sapiens_hsa011000.61901228
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59479633
117Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58846227
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58760591
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57968913
120Glycerolipid metabolism_Homo sapiens_hsa005610.57478653
121Basal transcription factors_Homo sapiens_hsa030220.55683424
122Toxoplasmosis_Homo sapiens_hsa051450.55254373
123Jak-STAT signaling pathway_Homo sapiens_hsa046300.55053373
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53806217
125Histidine metabolism_Homo sapiens_hsa003400.53710380
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.52893026
127beta-Alanine metabolism_Homo sapiens_hsa004100.52794615
128Vitamin digestion and absorption_Homo sapiens_hsa049770.52368047
129B cell receptor signaling pathway_Homo sapiens_hsa046620.51364960
130Regulation of autophagy_Homo sapiens_hsa041400.50990965
131GnRH signaling pathway_Homo sapiens_hsa049120.50273401
132Dopaminergic synapse_Homo sapiens_hsa047280.49794306
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49567888
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48705185
135Oxytocin signaling pathway_Homo sapiens_hsa049210.48515292
136Legionellosis_Homo sapiens_hsa051340.48416003
137Fat digestion and absorption_Homo sapiens_hsa049750.47940500
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47896184
139Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47578871
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47351664
141Prolactin signaling pathway_Homo sapiens_hsa049170.47240289
142Purine metabolism_Homo sapiens_hsa002300.46638280
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46429413
144Hepatitis B_Homo sapiens_hsa051610.45519417
145Hepatitis C_Homo sapiens_hsa051600.45271541
146Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44743312
147Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43944543
148MAPK signaling pathway_Homo sapiens_hsa040100.43486257
149T cell receptor signaling pathway_Homo sapiens_hsa046600.43133385
150Antigen processing and presentation_Homo sapiens_hsa046120.41957836
151Fatty acid metabolism_Homo sapiens_hsa012120.40941523
152Sulfur relay system_Homo sapiens_hsa041220.39800568

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