

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | vitamin A metabolic process (GO:0006776) | 8.81248249 |
| 2 | diterpenoid biosynthetic process (GO:0016102) | 7.72877514 |
| 3 | terpenoid biosynthetic process (GO:0016114) | 6.18270339 |
| 4 | righting reflex (GO:0060013) | 5.47355450 |
| 5 | regulation of lipoprotein metabolic process (GO:0050746) | 5.27048678 |
| 6 | muscle filament sliding (GO:0030049) | 5.23737563 |
| 7 | actin-myosin filament sliding (GO:0033275) | 5.23737563 |
| 8 | regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714) | 5.18055418 |
| 9 | ketone body metabolic process (GO:1902224) | 4.85289942 |
| 10 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 4.82866736 |
| 11 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 4.64456827 |
| 12 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 4.64311905 |
| 13 | positive regulation of osteoblast proliferation (GO:0033690) | 4.63312071 |
| 14 | retinal metabolic process (GO:0042574) | 4.61764276 |
| 15 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 4.59711354 |
| 16 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 4.57581267 |
| 17 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.37463820 |
| 18 | regulation of synapse structural plasticity (GO:0051823) | 4.34189079 |
| 19 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 4.34113397 |
| 20 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 4.26631034 |
| 21 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.21085094 |
| 22 | regulation of membrane repolarization (GO:0060306) | 4.19491543 |
| 23 | actin-mediated cell contraction (GO:0070252) | 4.17862694 |
| 24 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 4.17620068 |
| 25 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.12284360 |
| 26 | striatum development (GO:0021756) | 4.10166526 |
| 27 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 4.08715950 |
| 28 | cell communication by electrical coupling (GO:0010644) | 4.08285747 |
| 29 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 4.07730977 |
| 30 | melanin biosynthetic process (GO:0042438) | 4.05981118 |
| 31 | response to inactivity (GO:0014854) | 4.04296866 |
| 32 | cardiac myofibril assembly (GO:0055003) | 3.96296961 |
| 33 | prepulse inhibition (GO:0060134) | 3.92532718 |
| 34 | cell communication involved in cardiac conduction (GO:0086065) | 3.92313692 |
| 35 | secondary metabolite biosynthetic process (GO:0044550) | 3.87313516 |
| 36 | behavioral response to nicotine (GO:0035095) | 3.87095037 |
| 37 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 3.86429649 |
| 38 | locomotory exploration behavior (GO:0035641) | 3.85479465 |
| 39 | inositol metabolic process (GO:0006020) | 3.82296003 |
| 40 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.81710253 |
| 41 | short-term memory (GO:0007614) | 3.81449945 |
| 42 | vocalization behavior (GO:0071625) | 3.80815540 |
| 43 | regulation of skeletal muscle contraction (GO:0014819) | 3.80514253 |
| 44 | negative regulation of lipid storage (GO:0010888) | 3.80181025 |
| 45 | detection of calcium ion (GO:0005513) | 3.79938242 |
| 46 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.77282011 |
| 47 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.76087557 |
| 48 | regulation of cell communication by electrical coupling (GO:0010649) | 3.74351054 |
| 49 | striated muscle contraction (GO:0006941) | 3.71932118 |
| 50 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.71815123 |
| 51 | interkinetic nuclear migration (GO:0022027) | 3.71546993 |
| 52 | cardiac conduction (GO:0061337) | 3.69310636 |
| 53 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 3.68019015 |
| 54 | synapsis (GO:0007129) | 3.66098743 |
| 55 | adult heart development (GO:0007512) | 3.61721114 |
| 56 | synaptic vesicle maturation (GO:0016188) | 3.55739749 |
| 57 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.53196279 |
| 58 | regulation of actin filament-based movement (GO:1903115) | 3.52430170 |
| 59 | cardiac muscle contraction (GO:0060048) | 3.51792929 |
| 60 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 3.51343924 |
| 61 | melanin metabolic process (GO:0006582) | 3.50802812 |
| 62 | synaptic transmission, dopaminergic (GO:0001963) | 3.49908301 |
| 63 | glutamate receptor signaling pathway (GO:0007215) | 3.45619818 |
| 64 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.44562637 |
| 65 | neuron-neuron synaptic transmission (GO:0007270) | 3.42385172 |
| 66 | regulation of heart rate by cardiac conduction (GO:0086091) | 3.38717149 |
| 67 | myofibril assembly (GO:0030239) | 3.38369358 |
| 68 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.38323966 |
| 69 | regulation of relaxation of muscle (GO:1901077) | 3.36150563 |
| 70 | cellular potassium ion homeostasis (GO:0030007) | 3.35140267 |
| 71 | synaptic transmission, glutamatergic (GO:0035249) | 3.34504214 |
| 72 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.31913567 |
| 73 | relaxation of cardiac muscle (GO:0055119) | 3.31300770 |
| 74 | sarcomere organization (GO:0045214) | 3.31295587 |
| 75 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.30397800 |
| 76 | membrane repolarization during action potential (GO:0086011) | 3.29676424 |
| 77 | regulation of the force of heart contraction (GO:0002026) | 3.29493855 |
| 78 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.28791699 |
| 79 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.28791699 |
| 80 | ventricular cardiac muscle cell action potential (GO:0086005) | 3.25778614 |
| 81 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.24772251 |
| 82 | regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768) | 3.24321119 |
| 83 | membrane depolarization during action potential (GO:0086010) | 3.23712817 |
| 84 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 3.22901812 |
| 85 | reflex (GO:0060004) | 3.22850724 |
| 86 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.22223897 |
| 87 | multicellular organismal signaling (GO:0035637) | 3.22177198 |
| 88 | long-term memory (GO:0007616) | 3.22013515 |
| 89 | regulation of DNA endoreduplication (GO:0032875) | 3.21458865 |
| 90 | auditory behavior (GO:0031223) | 3.19659732 |
| 91 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.19579794 |
| 92 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.19044313 |
| 93 | cardiac muscle cell action potential (GO:0086001) | 3.18477293 |
| 94 | potassium ion export (GO:0071435) | 3.18001879 |
| 95 | regulation of sequestering of triglyceride (GO:0010889) | 3.17951533 |
| 96 | synaptic vesicle exocytosis (GO:0016079) | 3.17378091 |
| 97 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.16552147 |
| 98 | positive regulation of potassium ion transport (GO:0043268) | 3.16489403 |
| 99 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.15486392 |
| 100 | membrane repolarization (GO:0086009) | 3.15371558 |
| 101 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.14797542 |
| 102 | sodium ion export (GO:0071436) | 3.13308734 |
| 103 | behavioral response to cocaine (GO:0048148) | 3.11727070 |
| 104 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.11259731 |
| 105 | negative regulation of systemic arterial blood pressure (GO:0003085) | 3.09886799 |
| 106 | regulation of sarcomere organization (GO:0060297) | 3.08825001 |
| 107 | resolution of meiotic recombination intermediates (GO:0000712) | 3.08552121 |
| 108 | protein localization to synapse (GO:0035418) | 3.07513237 |
| 109 | negative chemotaxis (GO:0050919) | 3.07271092 |
| 110 | adenosine receptor signaling pathway (GO:0001973) | 3.05489818 |
| 111 | activation of protein kinase A activity (GO:0034199) | 3.04025460 |
| 112 | muscle cell cellular homeostasis (GO:0046716) | 3.03501653 |
| 113 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.02886396 |
| 114 | response to auditory stimulus (GO:0010996) | 3.02632658 |
| 115 | cardiac muscle cell development (GO:0055013) | 3.02199310 |
| 116 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.01947887 |
| 117 | regulation of postsynaptic membrane potential (GO:0060078) | 3.01843896 |
| 118 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.00617576 |
| 119 | response to muscle activity (GO:0014850) | 2.98446275 |
| 120 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.97179574 |
| 121 | positive regulation of neurotransmitter transport (GO:0051590) | 2.96724460 |
| 122 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.96407107 |
| 123 | regulation of cation channel activity (GO:2001257) | 2.96247788 |
| 124 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 2.95990978 |
| 125 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 2.95990978 |
| 126 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.95007009 |
| 127 | neuronal action potential propagation (GO:0019227) | 2.94975360 |
| 128 | isoprenoid biosynthetic process (GO:0008299) | 2.92591797 |
| 129 | neurotransmitter secretion (GO:0007269) | 2.92380545 |
| 130 | actomyosin structure organization (GO:0031032) | 2.92161212 |
| 131 | potassium ion import (GO:0010107) | 2.91702795 |
| 132 | response to amphetamine (GO:0001975) | 2.90320840 |
| 133 | dopamine receptor signaling pathway (GO:0007212) | 2.89986683 |
| 134 | cAMP catabolic process (GO:0006198) | 2.89021910 |
| 135 | myotube differentiation (GO:0014902) | 2.88592788 |
| 136 | membrane hyperpolarization (GO:0060081) | 2.88551648 |
| 137 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.88033380 |
| 138 | cardiac muscle hypertrophy (GO:0003300) | 2.87122699 |
| 139 | cAMP biosynthetic process (GO:0006171) | 2.86576667 |
| 140 | membrane depolarization (GO:0051899) | 2.86336036 |
| 141 | regulation of synaptic vesicle transport (GO:1902803) | 2.85131801 |
| 142 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.84812370 |
| 143 | regulation of cardiac muscle contraction (GO:0055117) | 2.84535393 |
| 144 | actin filament-based movement (GO:0030048) | 2.83350649 |
| 145 | regulation of hippo signaling (GO:0035330) | 2.80959886 |
| 146 | response to caffeine (GO:0031000) | 2.80164572 |
| 147 | striated muscle hypertrophy (GO:0014897) | 2.79224269 |
| 148 | meiotic chromosome segregation (GO:0045132) | 2.73019714 |
| 149 | regulation of receptor biosynthetic process (GO:0010869) | 2.70932154 |
| 150 | regulation of potassium ion transmembrane transport (GO:1901379) | 2.69666046 |
| 151 | creatine metabolic process (GO:0006600) | 2.68914399 |
| 152 | skeletal muscle contraction (GO:0003009) | 2.67975299 |
| 153 | regulation of ATPase activity (GO:0043462) | 2.67901807 |
| 154 | regulation of ATP catabolic process (GO:1903289) | 2.67901807 |
| 155 | positive regulation of cation channel activity (GO:2001259) | 2.66423378 |
| 156 | protein K6-linked ubiquitination (GO:0085020) | 2.64248845 |
| 157 | male meiosis I (GO:0007141) | 2.62608590 |
| 158 | cellular ketone body metabolic process (GO:0046950) | 2.61878778 |
| 159 | cardiac cell development (GO:0055006) | 2.60847378 |
| 160 | ubiquinone biosynthetic process (GO:0006744) | 2.60606632 |
| 161 | retinol metabolic process (GO:0042572) | 2.60225020 |
| 162 | regulation of apoptotic cell clearance (GO:2000425) | 2.59407100 |
| 163 | regulation of striated muscle contraction (GO:0006942) | 2.59289800 |
| 164 | auditory receptor cell stereocilium organization (GO:0060088) | 2.58602998 |
| 165 | negative regulation of response to food (GO:0032096) | 2.56787658 |
| 166 | negative regulation of appetite (GO:0032099) | 2.56787658 |
| 167 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 2.56786066 |
| 168 | primary amino compound metabolic process (GO:1901160) | 2.50620110 |
| 169 | retinoic acid metabolic process (GO:0042573) | 2.49949894 |
| 170 | muscle contraction (GO:0006936) | 2.49924289 |
| 171 | kynurenine metabolic process (GO:0070189) | 2.49908162 |
| 172 | regulation of potassium ion transmembrane transporter activity (GO:1901016) | 2.49197800 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.73640673 |
| 2 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.84635507 |
| 3 | VDR_22108803_ChIP-Seq_LS180_Human | 3.32983440 |
| 4 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.13357063 |
| 5 | GATA1_22025678_ChIP-Seq_K562_Human | 3.10326458 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.79036611 |
| 7 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.74691024 |
| 8 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.61941963 |
| 9 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.60581623 |
| 10 | FUS_26573619_Chip-Seq_HEK293_Human | 2.47650783 |
| 11 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.38733912 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.35243643 |
| 13 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.35243643 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.26004603 |
| 15 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.23916031 |
| 16 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.23775810 |
| 17 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 2.19284155 |
| 18 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.18709310 |
| 19 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.16284559 |
| 20 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.14474118 |
| 21 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.11017581 |
| 22 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.08694529 |
| 23 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.04711381 |
| 24 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.02725067 |
| 25 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.02141668 |
| 26 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.97712522 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.94792803 |
| 28 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.92768815 |
| 29 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.85695113 |
| 30 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.77277848 |
| 31 | EWS_26573619_Chip-Seq_HEK293_Human | 1.72005525 |
| 32 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.71374824 |
| 33 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.70993354 |
| 34 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.70811605 |
| 35 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 1.68893181 |
| 36 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.67258973 |
| 37 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.63791752 |
| 38 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.60376768 |
| 39 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 1.58066933 |
| 40 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.57828248 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.56038453 |
| 42 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.54012325 |
| 43 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.52762624 |
| 44 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.51445712 |
| 45 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.49289016 |
| 46 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.48951662 |
| 47 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.48095452 |
| 48 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.46211120 |
| 49 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.45333100 |
| 50 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.41350817 |
| 51 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.40663383 |
| 52 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.39308365 |
| 53 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.36157980 |
| 54 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.35698012 |
| 55 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.35698012 |
| 56 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.35484940 |
| 57 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.32757842 |
| 58 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.31187378 |
| 59 | PHF8_20622853_ChIP-Seq_HELA_Human | 1.29782759 |
| 60 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.28610260 |
| 61 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.28529728 |
| 62 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.28471204 |
| 63 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.27272768 |
| 64 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.25242527 |
| 65 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.25106292 |
| 66 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 1.24146423 |
| 67 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.23891494 |
| 68 | STAT3_23295773_ChIP-Seq_U87_Human | 1.23549719 |
| 69 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.23415948 |
| 70 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.23413976 |
| 71 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.22830849 |
| 72 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.22200084 |
| 73 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.22083913 |
| 74 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.21738601 |
| 75 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.20796725 |
| 76 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.19618191 |
| 77 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.19586942 |
| 78 | P300_19829295_ChIP-Seq_ESCs_Human | 1.19204306 |
| 79 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.18320352 |
| 80 | NFYB_21822215_ChIP-Seq_K562_Human | 1.18277952 |
| 81 | TCF4_23295773_ChIP-Seq_U87_Human | 1.17996355 |
| 82 | AR_19668381_ChIP-Seq_PC3_Human | 1.17845775 |
| 83 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.17178742 |
| 84 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.16782883 |
| 85 | TBL1_22424771_ChIP-Seq_293T_Human | 1.16676030 |
| 86 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.16568331 |
| 87 | ETV1_20927104_ChIP-Seq_GIST48_Human | 1.16053359 |
| 88 | JUN_21703547_ChIP-Seq_K562_Human | 1.15648419 |
| 89 | GATA2_19941826_ChIP-Seq_K562_Human | 1.14961181 |
| 90 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.14064045 |
| 91 | TP53_16413492_ChIP-PET_HCT116_Human | 1.13798300 |
| 92 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.13602624 |
| 93 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 1.11825387 |
| 94 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.11222164 |
| 95 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.11181220 |
| 96 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.10858899 |
| 97 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.10758535 |
| 98 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.10703165 |
| 99 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.10673773 |
| 100 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.10502790 |
| 101 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.10101023 |
| 102 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.09942164 |
| 103 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.09419387 |
| 104 | GATA1_19941826_ChIP-Seq_K562_Human | 1.09352856 |
| 105 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.08829488 |
| 106 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.08727356 |
| 107 | PCGF4_22325352_ChIP-Seq_293T-Rex_Human | 1.08420036 |
| 108 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.08350989 |
| 109 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.08319946 |
| 110 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 1.07562639 |
| 111 | ETV2_25802403_ChIP-Seq_MESCs_Mouse | 1.07473324 |
| 112 | AR_25329375_ChIP-Seq_VCAP_Human | 1.07280036 |
| 113 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.06733837 |
| 114 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.06711126 |
| 115 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.06597357 |
| 116 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.06433086 |
| 117 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.06401659 |
| 118 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.05624742 |
| 119 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05521114 |
| 120 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.05088218 |
| 121 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 1.04806943 |
| 122 | LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.03628189 |
| 123 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.03277857 |
| 124 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03277857 |
| 125 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 1.03275958 |
| 126 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.03083759 |
| 127 | HNFA_21074721_ChIP-Seq_CACO-2_Human | 1.02447345 |
| 128 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 1.02362457 |
| 129 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.01499124 |
| 130 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.01364005 |
| 131 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 1.01101398 |
| 132 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.00690654 |
| 133 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.00066543 |
| 134 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.99931633 |
| 135 | RBPJ_21746931_ChIP-Seq_IB4_Human | 0.99750366 |
| 136 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.99717084 |
| 137 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.99656809 |
| 138 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.99131432 |
| 139 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.98480065 |
| 140 | ELK1_19687146_ChIP-ChIP_HELA_Human | 0.98384587 |
| 141 | NCOR_22424771_ChIP-Seq_293T_Human | 0.98102094 |
| 142 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.97635797 |
| 143 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.97446128 |
| 144 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.97446128 |
| 145 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.96921663 |
| 146 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.96630955 |
| 147 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.96264242 |
| 148 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.96248166 |
| 149 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.96248166 |
| 150 | NFYA_21822215_ChIP-Seq_K562_Human | 0.95943270 |
| 151 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.94451049 |
| 152 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 0.94380542 |
| 153 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.94172257 |
| 154 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 0.93833112 |
| 155 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 0.93754223 |
| 156 | KDM2B_26808549_Chip-Seq_K562_Human | 0.93529765 |
| 157 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.93404933 |
| 158 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.93359463 |
| 159 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.93335743 |
| 160 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 0.93210619 |
| 161 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.91786959 |
| 162 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 0.91656995 |
| 163 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.90832405 |
| 164 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.89788307 |
| 165 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.89524110 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003011_delayed_dark_adaptation | 5.18261348 |
| 2 | MP0002822_catalepsy | 4.85883797 |
| 3 | MP0004859_abnormal_synaptic_plasticity | 4.57466760 |
| 4 | MP0002837_dystrophic_cardiac_calcinosis | 3.45713033 |
| 5 | MP0004215_abnormal_myocardial_fiber | 3.35746216 |
| 6 | MP0003880_abnormal_central_pattern | 3.30651320 |
| 7 | MP0005171_absent_coat_pigmentation | 3.22991543 |
| 8 | MP0004084_abnormal_cardiac_muscle | 3.20297298 |
| 9 | MP0000372_irregular_coat_pigmentation | 3.17288155 |
| 10 | MP0003635_abnormal_synaptic_transmissio | 3.11421375 |
| 11 | MP0004510_myositis | 3.03711820 |
| 12 | MP0009046_muscle_twitch | 3.02781847 |
| 13 | MP0003646_muscle_fatigue | 2.96019504 |
| 14 | MP0000751_myopathy | 2.88315996 |
| 15 | MP0009745_abnormal_behavioral_response | 2.82767254 |
| 16 | MP0003878_abnormal_ear_physiology | 2.58168656 |
| 17 | MP0005377_hearing/vestibular/ear_phenot | 2.58168656 |
| 18 | MP0004036_abnormal_muscle_relaxation | 2.52333924 |
| 19 | MP0002063_abnormal_learning/memory/cond | 2.50025063 |
| 20 | MP0005248_abnormal_Harderian_gland | 2.44024945 |
| 21 | MP0002064_seizures | 2.31204809 |
| 22 | MP0003136_yellow_coat_color | 2.29999047 |
| 23 | MP0003137_abnormal_impulse_conducting | 2.28488181 |
| 24 | MP0005423_abnormal_somatic_nervous | 2.22956266 |
| 25 | MP0001486_abnormal_startle_reflex | 2.20875202 |
| 26 | MP0002272_abnormal_nervous_system | 2.16551819 |
| 27 | MP0003950_abnormal_plasma_membrane | 2.16205478 |
| 28 | MP0002638_abnormal_pupillary_reflex | 2.12531509 |
| 29 | MP0002572_abnormal_emotion/affect_behav | 2.09392726 |
| 30 | MP0004147_increased_porphyrin_level | 2.08990424 |
| 31 | MP0004270_analgesia | 2.04344683 |
| 32 | MP0002102_abnormal_ear_morphology | 1.95660594 |
| 33 | MP0002972_abnormal_cardiac_muscle | 1.95363143 |
| 34 | MP0008569_lethality_at_weaning | 1.91757202 |
| 35 | MP0001968_abnormal_touch/_nociception | 1.89128403 |
| 36 | MP0004085_abnormal_heartbeat | 1.88097368 |
| 37 | MP0005330_cardiomyopathy | 1.87380030 |
| 38 | MP0008775_abnormal_heart_ventricle | 1.84539227 |
| 39 | MP0005408_hypopigmentation | 1.84047526 |
| 40 | MP0005187_abnormal_penis_morphology | 1.80692455 |
| 41 | MP0009697_abnormal_copulation | 1.79262889 |
| 42 | MP0004924_abnormal_behavior | 1.74118201 |
| 43 | MP0005386_behavior/neurological_phenoty | 1.74118201 |
| 44 | MP0001501_abnormal_sleep_pattern | 1.71215523 |
| 45 | MP0005253_abnormal_eye_physiology | 1.70551437 |
| 46 | MP0002909_abnormal_adrenal_gland | 1.68143560 |
| 47 | MP0005620_abnormal_muscle_contractility | 1.67575925 |
| 48 | MP0001324_abnormal_eye_pigmentation | 1.64204267 |
| 49 | MP0002254_reproductive_system_inflammat | 1.59031292 |
| 50 | MP0004145_abnormal_muscle_electrophysio | 1.58834578 |
| 51 | MP0004484_altered_response_of | 1.58648578 |
| 52 | MP0002067_abnormal_sensory_capabilities | 1.55590604 |
| 53 | MP0000371_diluted_coat_color | 1.50945219 |
| 54 | MP0002095_abnormal_skin_pigmentation | 1.50179872 |
| 55 | MP0005646_abnormal_pituitary_gland | 1.47531858 |
| 56 | MP0004087_abnormal_muscle_fiber | 1.46755642 |
| 57 | MP0000749_muscle_degeneration | 1.45771119 |
| 58 | MP0000747_muscle_weakness | 1.45561738 |
| 59 | MP0002734_abnormal_mechanical_nocicepti | 1.44075927 |
| 60 | MP0001529_abnormal_vocalization | 1.43633268 |
| 61 | MP0003879_abnormal_hair_cell | 1.41435972 |
| 62 | MP0002735_abnormal_chemical_nociception | 1.40893558 |
| 63 | MP0001440_abnormal_grooming_behavior | 1.40761172 |
| 64 | MP0006138_congestive_heart_failure | 1.38535773 |
| 65 | MP0003300_gastrointestinal_ulcer | 1.37960789 |
| 66 | MP0001544_abnormal_cardiovascular_syste | 1.37658343 |
| 67 | MP0005385_cardiovascular_system_phenoty | 1.37658343 |
| 68 | MP0004130_abnormal_muscle_cell | 1.32682679 |
| 69 | MP0001984_abnormal_olfaction | 1.31805619 |
| 70 | MP0001188_hyperpigmentation | 1.30741764 |
| 71 | MP0000569_abnormal_digit_pigmentation | 1.26633981 |
| 72 | MP0001970_abnormal_pain_threshold | 1.25344190 |
| 73 | MP0002184_abnormal_innervation | 1.25287740 |
| 74 | MP0002106_abnormal_muscle_physiology | 1.23377407 |
| 75 | MP0002736_abnormal_nociception_after | 1.22339753 |
| 76 | MP0002557_abnormal_social/conspecific_i | 1.22007906 |
| 77 | MP0006036_abnormal_mitochondrial_physio | 1.19339851 |
| 78 | MP0005551_abnormal_eye_electrophysiolog | 1.18759851 |
| 79 | MP0005409_darkened_coat_color | 1.15973944 |
| 80 | MP0001502_abnormal_circadian_rhythm | 1.14518272 |
| 81 | MP0003656_abnormal_erythrocyte_physiolo | 1.12864627 |
| 82 | MP0002075_abnormal_coat/hair_pigmentati | 1.07530535 |
| 83 | MP0010630_abnormal_cardiac_muscle | 1.07162530 |
| 84 | MP0005257_abnormal_intraocular_pressure | 1.04099615 |
| 85 | MP0002733_abnormal_thermal_nociception | 1.03216863 |
| 86 | MP0003828_pulmonary_edema | 1.00741157 |
| 87 | MP0002066_abnormal_motor_capabilities/c | 1.00190256 |
| 88 | MP0001661_extended_life_span | 0.99679543 |
| 89 | MP0004811_abnormal_neuron_physiology | 0.98846986 |
| 90 | MP0005195_abnormal_posterior_eye | 0.97468189 |
| 91 | MP0005369_muscle_phenotype | 0.96068714 |
| 92 | MP0002090_abnormal_vision | 0.95586611 |
| 93 | MP0005645_abnormal_hypothalamus_physiol | 0.94218695 |
| 94 | MP0001348_abnormal_lacrimal_gland | 0.94003743 |
| 95 | MP0008872_abnormal_physiological_respon | 0.92669743 |
| 96 | MP0005174_abnormal_tail_pigmentation | 0.92130684 |
| 97 | MP0008874_decreased_physiological_sensi | 0.91189643 |
| 98 | MP0004185_abnormal_adipocyte_glucose | 0.91117929 |
| 99 | MP0002127_abnormal_cardiovascular_syste | 0.90570085 |
| 100 | MP0002877_abnormal_melanocyte_morpholog | 0.90099095 |
| 101 | MP0002882_abnormal_neuron_morphology | 0.89702491 |
| 102 | MP0010094_abnormal_chromosome_stability | 0.88872545 |
| 103 | MP0002160_abnormal_reproductive_system | 0.88517973 |
| 104 | MP0003787_abnormal_imprinting | 0.88255827 |
| 105 | MP0000465_gastrointestinal_hemorrhage | 0.87780323 |
| 106 | MP0003633_abnormal_nervous_system | 0.87681557 |
| 107 | MP0005535_abnormal_body_temperature | 0.86059639 |
| 108 | MP0000778_abnormal_nervous_system | 0.85519117 |
| 109 | MP0005197_abnormal_uvea_morphology | 0.85448389 |
| 110 | MP0005310_abnormal_salivary_gland | 0.85086763 |
| 111 | MP0005083_abnormal_biliary_tract | 0.84740028 |
| 112 | MP0009780_abnormal_chondrocyte_physiolo | 0.83932910 |
| 113 | MP0004142_abnormal_muscle_tone | 0.82891556 |
| 114 | MP0004233_abnormal_muscle_weight | 0.82483083 |
| 115 | MP0002938_white_spotting | 0.81625865 |
| 116 | MP0000383_abnormal_hair_follicle | 0.80903716 |
| 117 | MP0008058_abnormal_DNA_repair | 0.78678988 |
| 118 | MP0004043_abnormal_pH_regulation | 0.77887503 |
| 119 | MP0004134_abnormal_chest_morphology | 0.75932926 |
| 120 | MP0010386_abnormal_urinary_bladder | 0.75808399 |
| 121 | MP0002229_neurodegeneration | 0.75232667 |
| 122 | MP0000759_abnormal_skeletal_muscle | 0.75160443 |
| 123 | MP0001485_abnormal_pinna_reflex | 0.74842697 |
| 124 | MP0002269_muscular_atrophy | 0.74349150 |
| 125 | MP0003045_fibrosis | 0.74272610 |
| 126 | MP0001346_abnormal_lacrimal_gland | 0.73449833 |
| 127 | MP0001186_pigmentation_phenotype | 0.72744421 |
| 128 | MP0008995_early_reproductive_senescence | 0.72371101 |
| 129 | MP0005266_abnormal_metabolism | 0.72222363 |
| 130 | MP0000013_abnormal_adipose_tissue | 0.72196713 |
| 131 | MP0002138_abnormal_hepatobiliary_system | 0.72012265 |
| 132 | MP0002234_abnormal_pharynx_morphology | 0.71975892 |
| 133 | MP0003890_abnormal_embryonic-extraembry | 0.71850707 |
| 134 | MP0006072_abnormal_retinal_apoptosis | 0.71490086 |
| 135 | MP0000955_abnormal_spinal_cord | 0.70230970 |
| 136 | MP0000647_abnormal_sebaceous_gland | 0.70139160 |
| 137 | MP0004858_abnormal_nervous_system | 0.69904895 |
| 138 | MP0005391_vision/eye_phenotype | 0.68421388 |
| 139 | MP0003631_nervous_system_phenotype | 0.67454076 |
| 140 | MP0003786_premature_aging | 0.66616182 |
| 141 | MP0006035_abnormal_mitochondrial_morpho | 0.65754634 |
| 142 | MP0000230_abnormal_systemic_arterial | 0.65676768 |
| 143 | MP0005167_abnormal_blood-brain_barrier | 0.65434161 |
| 144 | MP0000750_abnormal_muscle_regeneration | 0.65214706 |
| 145 | MP0000015_abnormal_ear_pigmentation | 0.64916931 |
| 146 | MP0000631_abnormal_neuroendocrine_gland | 0.64571915 |
| 147 | MP0008961_abnormal_basal_metabolism | 0.63895275 |
| 148 | MP0006276_abnormal_autonomic_nervous | 0.62449964 |
| 149 | MP0004885_abnormal_endolymph | 0.61375385 |
| 150 | MP0004742_abnormal_vestibular_system | 0.61250644 |
| 151 | MP0002332_abnormal_exercise_endurance | 0.60958320 |
| 152 | MP0000733_abnormal_muscle_development | 0.60603267 |
| 153 | MP0003937_abnormal_limbs/digits/tail_de | 0.58913972 |
| 154 | MP0002752_abnormal_somatic_nervous | 0.58603568 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Sudden death (HP:0001699) | 6.29900345 |
| 2 | Abnormality of the fovea (HP:0000493) | 5.93349237 |
| 3 | Atrial fibrillation (HP:0005110) | 5.65661512 |
| 4 | Muscle fiber inclusion bodies (HP:0100299) | 5.59593095 |
| 5 | Focal motor seizures (HP:0011153) | 5.48379375 |
| 6 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 5.46171158 |
| 7 | Prolonged QT interval (HP:0001657) | 5.45494853 |
| 8 | Primary atrial arrhythmia (HP:0001692) | 5.35518605 |
| 9 | Myokymia (HP:0002411) | 5.33039402 |
| 10 | Nemaline bodies (HP:0003798) | 5.28616413 |
| 11 | Syncope (HP:0001279) | 5.15314914 |
| 12 | Supraventricular tachycardia (HP:0004755) | 5.06644415 |
| 13 | Supraventricular arrhythmia (HP:0005115) | 4.91871839 |
| 14 | Ventricular fibrillation (HP:0001663) | 4.80195445 |
| 15 | Bundle branch block (HP:0011710) | 4.44396227 |
| 16 | Choroideremia (HP:0001139) | 4.37551709 |
| 17 | Abnormal EKG (HP:0003115) | 4.33579030 |
| 18 | Focal seizures (HP:0007359) | 4.06595750 |
| 19 | Ventricular tachycardia (HP:0004756) | 3.93656967 |
| 20 | Febrile seizures (HP:0002373) | 3.84436444 |
| 21 | Subaortic stenosis (HP:0001682) | 3.82365962 |
| 22 | Abnormality of the left ventricular outflow tract (HP:0011103) | 3.82365962 |
| 23 | Gaze-evoked nystagmus (HP:0000640) | 3.77455250 |
| 24 | Dysmetric saccades (HP:0000641) | 3.75738485 |
| 25 | Ventricular arrhythmia (HP:0004308) | 3.71287455 |
| 26 | Heart block (HP:0012722) | 3.67845903 |
| 27 | Exercise-induced myalgia (HP:0003738) | 3.55706922 |
| 28 | Visual hallucinations (HP:0002367) | 3.54520908 |
| 29 | Calf muscle hypertrophy (HP:0008981) | 3.52949007 |
| 30 | Type 1 muscle fiber predominance (HP:0003803) | 3.46225598 |
| 31 | Progressive cerebellar ataxia (HP:0002073) | 3.42492809 |
| 32 | Action tremor (HP:0002345) | 3.40462318 |
| 33 | Dysdiadochokinesis (HP:0002075) | 3.39272633 |
| 34 | Atrioventricular block (HP:0001678) | 3.36490822 |
| 35 | Abnormal atrioventricular conduction (HP:0005150) | 3.34494506 |
| 36 | Abnormality of the calf musculature (HP:0001430) | 3.30545590 |
| 37 | Epileptic encephalopathy (HP:0200134) | 3.25273917 |
| 38 | Abnormal rod and cone electroretinograms (HP:0008323) | 3.23659035 |
| 39 | Muscle hypertrophy of the lower extremities (HP:0008968) | 3.13948051 |
| 40 | Bony spicule pigmentary retinopathy (HP:0007737) | 3.07173571 |
| 41 | Central scotoma (HP:0000603) | 3.03578627 |
| 42 | Hypoplasia of the fovea (HP:0007750) | 3.02730547 |
| 43 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 3.02730547 |
| 44 | Lipoatrophy (HP:0100578) | 3.00491031 |
| 45 | Broad-based gait (HP:0002136) | 2.97802166 |
| 46 | Absence seizures (HP:0002121) | 2.93224471 |
| 47 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.92647914 |
| 48 | Abnormality of alanine metabolism (HP:0010916) | 2.92647914 |
| 49 | Hyperalaninemia (HP:0003348) | 2.92647914 |
| 50 | Poor eye contact (HP:0000817) | 2.86333437 |
| 51 | Palpitations (HP:0001962) | 2.79483902 |
| 52 | Hypopigmentation of the fundus (HP:0007894) | 2.78960805 |
| 53 | Rimmed vacuoles (HP:0003805) | 2.73790582 |
| 54 | Left ventricular hypertrophy (HP:0001712) | 2.72216340 |
| 55 | Right ventricular cardiomyopathy (HP:0011663) | 2.71997896 |
| 56 | Anxiety (HP:0000739) | 2.69891082 |
| 57 | Dilated cardiomyopathy (HP:0001644) | 2.69498597 |
| 58 | Atonic seizures (HP:0010819) | 2.67771147 |
| 59 | Dialeptic seizures (HP:0011146) | 2.67426041 |
| 60 | Generalized tonic-clonic seizures (HP:0002069) | 2.65569608 |
| 61 | Exercise-induced muscle cramps (HP:0003710) | 2.54677007 |
| 62 | Abnormal social behavior (HP:0012433) | 2.53320808 |
| 63 | Impaired social interactions (HP:0000735) | 2.53320808 |
| 64 | Lower limb amyotrophy (HP:0007210) | 2.50462023 |
| 65 | Severe visual impairment (HP:0001141) | 2.50299195 |
| 66 | Depression (HP:0000716) | 2.49777665 |
| 67 | Truncal ataxia (HP:0002078) | 2.46713439 |
| 68 | Congenital stationary night blindness (HP:0007642) | 2.45828271 |
| 69 | Pendular nystagmus (HP:0012043) | 2.42095199 |
| 70 | Impaired smooth pursuit (HP:0007772) | 2.39055590 |
| 71 | Dysmetria (HP:0001310) | 2.37853540 |
| 72 | Scanning speech (HP:0002168) | 2.37570311 |
| 73 | Annular pancreas (HP:0001734) | 2.29503955 |
| 74 | Genetic anticipation (HP:0003743) | 2.27222478 |
| 75 | Pheochromocytoma (HP:0002666) | 2.22893965 |
| 76 | Aplasia/Hypoplasia of the macula (HP:0008059) | 2.22002703 |
| 77 | Myopathic facies (HP:0002058) | 2.20539523 |
| 78 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.19544611 |
| 79 | Muscle fiber splitting (HP:0003555) | 2.18939662 |
| 80 | Myotonia (HP:0002486) | 2.18828978 |
| 81 | Hyporeflexia of lower limbs (HP:0002600) | 2.17563854 |
| 82 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.17265044 |
| 83 | Hemiplegia (HP:0002301) | 2.16221254 |
| 84 | Macular degeneration (HP:0000608) | 2.15599214 |
| 85 | Colon cancer (HP:0003003) | 2.15577253 |
| 86 | Optic nerve hypoplasia (HP:0000609) | 2.14860379 |
| 87 | Acute necrotizing encephalopathy (HP:0006965) | 2.13104169 |
| 88 | Abnormality of the renal collecting system (HP:0004742) | 2.11914693 |
| 89 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 2.10170045 |
| 90 | Homocystinuria (HP:0002156) | 2.09367931 |
| 91 | Abnormality of homocysteine metabolism (HP:0010919) | 2.09367931 |
| 92 | Abnormality of ocular smooth pursuit (HP:0000617) | 2.09098997 |
| 93 | EMG: myopathic abnormalities (HP:0003458) | 2.08755868 |
| 94 | Distal lower limb amyotrophy (HP:0008944) | 2.08732599 |
| 95 | Tinnitus (HP:0000360) | 2.07997578 |
| 96 | Progressive inability to walk (HP:0002505) | 2.06246868 |
| 97 | Rhabdomyolysis (HP:0003201) | 2.05609835 |
| 98 | Asymmetric septal hypertrophy (HP:0001670) | 2.05526640 |
| 99 | Chromsome breakage (HP:0040012) | 2.04226228 |
| 100 | Aplasia/Hypoplasia affecting the retina (HP:0008061) | 2.03709589 |
| 101 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.02766535 |
| 102 | Ankle clonus (HP:0011448) | 2.02582072 |
| 103 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.02371485 |
| 104 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.02338362 |
| 105 | Stereotypic behavior (HP:0000733) | 2.01809327 |
| 106 | Paralysis (HP:0003470) | 2.01081930 |
| 107 | Acute encephalopathy (HP:0006846) | 2.00915474 |
| 108 | Abnormality of saccadic eye movements (HP:0000570) | 2.00275790 |
| 109 | Ocular albinism (HP:0001107) | 1.99574856 |
| 110 | EMG: neuropathic changes (HP:0003445) | 1.97496500 |
| 111 | Hyperventilation (HP:0002883) | 1.97339766 |
| 112 | Torticollis (HP:0000473) | 1.96946442 |
| 113 | Bilateral sensorineural hearing impairment (HP:0008619) | 1.93358316 |
| 114 | Postural instability (HP:0002172) | 1.93053182 |
| 115 | Pancreatic fibrosis (HP:0100732) | 1.92191388 |
| 116 | Neuroendocrine neoplasm (HP:0100634) | 1.91542186 |
| 117 | Truncus arteriosus (HP:0001660) | 1.91357505 |
| 118 | Generalized muscle weakness (HP:0003324) | 1.90148128 |
| 119 | Sudden cardiac death (HP:0001645) | 1.89000163 |
| 120 | Poikilocytosis (HP:0004447) | 1.88833095 |
| 121 | Areflexia of lower limbs (HP:0002522) | 1.87419833 |
| 122 | Bradycardia (HP:0001662) | 1.87323986 |
| 123 | Myoglobinuria (HP:0002913) | 1.87146063 |
| 124 | Scotoma (HP:0000575) | 1.86617241 |
| 125 | Pointed chin (HP:0000307) | 1.85945573 |
| 126 | Blue irides (HP:0000635) | 1.85137998 |
| 127 | Neck muscle weakness (HP:0000467) | 1.84955080 |
| 128 | Type II lissencephaly (HP:0007260) | 1.83340041 |
| 129 | Distal arthrogryposis (HP:0005684) | 1.83312945 |
| 130 | Increased serum pyruvate (HP:0003542) | 1.83108195 |
| 131 | Absent phalangeal crease (HP:0006109) | 1.81272459 |
| 132 | Congenital sensorineural hearing impairment (HP:0008527) | 1.80814870 |
| 133 | Methylmalonic acidemia (HP:0002912) | 1.80541631 |
| 134 | Abolished electroretinogram (ERG) (HP:0000550) | 1.80024856 |
| 135 | Horizontal nystagmus (HP:0000666) | 1.80003713 |
| 136 | Progressive macrocephaly (HP:0004481) | 1.79515385 |
| 137 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.79431151 |
| 138 | Hemiparesis (HP:0001269) | 1.78097164 |
| 139 | Congenital malformation of the right heart (HP:0011723) | 1.77675606 |
| 140 | Double outlet right ventricle (HP:0001719) | 1.77675606 |
| 141 | Frequent falls (HP:0002359) | 1.77176822 |
| 142 | 3-Methylglutaconic aciduria (HP:0003535) | 1.74833572 |
| 143 | Abnormality of DNA repair (HP:0003254) | 1.74592283 |
| 144 | Reticulocytosis (HP:0001923) | 1.73760316 |
| 145 | Albinism (HP:0001022) | 1.73640193 |
| 146 | Abnormality of the periventricular white matter (HP:0002518) | 1.71912824 |
| 147 | Iris hypopigmentation (HP:0007730) | 1.70655527 |
| 148 | Cholecystitis (HP:0001082) | 1.70289943 |
| 149 | Abnormal gallbladder physiology (HP:0012438) | 1.70289943 |
| 150 | Beaking of vertebral bodies (HP:0004568) | 1.70184324 |
| 151 | Nephronophthisis (HP:0000090) | 1.69171921 |
| 152 | Abnormality of macular pigmentation (HP:0008002) | 1.68984850 |
| 153 | Resting tremor (HP:0002322) | 1.68934757 |
| 154 | Pancreatic cysts (HP:0001737) | 1.68463009 |
| 155 | Duplicated collecting system (HP:0000081) | 1.68225806 |
| 156 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.67467127 |
| 157 | Abnormality of glycolysis (HP:0004366) | 1.66746681 |
| 158 | Palpebral edema (HP:0100540) | 1.65150553 |
| 159 | Intention tremor (HP:0002080) | 1.63946213 |
| 160 | Urinary urgency (HP:0000012) | 1.59996193 |
| 161 | Incomplete penetrance (HP:0003829) | 1.58399000 |
| 162 | Spinal canal stenosis (HP:0003416) | 1.55362324 |
| 163 | Impaired vibratory sensation (HP:0002495) | 1.54994998 |
| 164 | Focal dystonia (HP:0004373) | 1.54487502 |
| 165 | Difficulty running (HP:0009046) | 1.53395474 |
| 166 | Pulmonary artery stenosis (HP:0004415) | 1.51508287 |
| 167 | Dyschromatopsia (HP:0007641) | 1.48309614 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.69276301 |
| 2 | MST1R | 4.49876009 |
| 3 | NTRK3 | 3.44655217 |
| 4 | MAP3K13 | 2.70463911 |
| 5 | MET | 2.65885394 |
| 6 | RIPK4 | 2.34804899 |
| 7 | LMTK2 | 2.32898751 |
| 8 | WNK4 | 2.23413964 |
| 9 | CAMKK1 | 2.16693276 |
| 10 | MAP3K4 | 2.09359314 |
| 11 | PHKG2 | 2.04992337 |
| 12 | PHKG1 | 2.04992337 |
| 13 | MAP3K9 | 2.01592047 |
| 14 | DMPK | 1.88174412 |
| 15 | MAP2K7 | 1.86109081 |
| 16 | STK38 | 1.79898161 |
| 17 | CAMKK2 | 1.79849775 |
| 18 | PINK1 | 1.73804151 |
| 19 | CDC7 | 1.68927685 |
| 20 | PRKD3 | 1.68274246 |
| 21 | TRPM7 | 1.66786800 |
| 22 | MARK3 | 1.65740517 |
| 23 | DAPK2 | 1.64282810 |
| 24 | MAP3K14 | 1.64076503 |
| 25 | BMX | 1.58688229 |
| 26 | PAK6 | 1.58069985 |
| 27 | NTRK2 | 1.57844396 |
| 28 | EIF2AK1 | 1.57161978 |
| 29 | WNK1 | 1.56581571 |
| 30 | FRK | 1.55053143 |
| 31 | ADRBK2 | 1.54572870 |
| 32 | SGK2 | 1.46788751 |
| 33 | NME1 | 1.46700703 |
| 34 | MINK1 | 1.46349185 |
| 35 | TNIK | 1.43134705 |
| 36 | DDR2 | 1.42742204 |
| 37 | MARK1 | 1.42539335 |
| 38 | KSR2 | 1.38937444 |
| 39 | BMPR2 | 1.37293349 |
| 40 | PRPF4B | 1.33818672 |
| 41 | STK24 | 1.31374969 |
| 42 | PNCK | 1.30413180 |
| 43 | TTK | 1.27616562 |
| 44 | MYLK | 1.26671989 |
| 45 | BRSK2 | 1.25725087 |
| 46 | STK38L | 1.24794736 |
| 47 | STK39 | 1.22001253 |
| 48 | WEE1 | 1.21452699 |
| 49 | INSRR | 1.19822115 |
| 50 | PDK4 | 1.19214284 |
| 51 | PDK3 | 1.19214284 |
| 52 | RIPK1 | 1.18940303 |
| 53 | SGK3 | 1.18377486 |
| 54 | CDK5 | 1.18346086 |
| 55 | SIK2 | 1.17022924 |
| 56 | MUSK | 1.14868968 |
| 57 | SGK1 | 1.14695782 |
| 58 | CAMK2A | 1.13632188 |
| 59 | SGK494 | 1.12347912 |
| 60 | SGK223 | 1.12347912 |
| 61 | BMPR1B | 1.11512820 |
| 62 | CAMK2D | 1.09251593 |
| 63 | CDC42BPA | 1.07855114 |
| 64 | OBSCN | 1.06959665 |
| 65 | CAMK1 | 1.06511786 |
| 66 | CAMK4 | 1.05878444 |
| 67 | KSR1 | 1.04875554 |
| 68 | CLK1 | 1.04594493 |
| 69 | PLK4 | 1.03062287 |
| 70 | SIK3 | 0.99035003 |
| 71 | ARAF | 0.98553264 |
| 72 | PRKAA2 | 0.97488665 |
| 73 | PKN1 | 0.96395656 |
| 74 | MAPK13 | 0.95339672 |
| 75 | TTN | 0.93770543 |
| 76 | FES | 0.92118072 |
| 77 | STK11 | 0.90420120 |
| 78 | GRK7 | 0.90025843 |
| 79 | STK3 | 0.89056999 |
| 80 | PTK2B | 0.88845083 |
| 81 | MAP2K1 | 0.87760710 |
| 82 | MAP2K4 | 0.87756487 |
| 83 | PAK3 | 0.86885928 |
| 84 | JAK1 | 0.82913513 |
| 85 | PRKCE | 0.82752277 |
| 86 | CSNK1A1L | 0.81691357 |
| 87 | PDK1 | 0.81566874 |
| 88 | CCNB1 | 0.81512761 |
| 89 | CSNK1G2 | 0.79203565 |
| 90 | RET | 0.79024054 |
| 91 | PIK3CG | 0.78941011 |
| 92 | CSNK1G3 | 0.77877041 |
| 93 | NEK1 | 0.75127145 |
| 94 | MAP3K7 | 0.71143036 |
| 95 | PRKCH | 0.69661366 |
| 96 | CSNK1G1 | 0.67372605 |
| 97 | PRKAA1 | 0.64779372 |
| 98 | TLK1 | 0.63948576 |
| 99 | CASK | 0.63938680 |
| 100 | PDK2 | 0.63902280 |
| 101 | MAPKAPK3 | 0.63268083 |
| 102 | CHEK2 | 0.62765769 |
| 103 | NTRK1 | 0.62386220 |
| 104 | MAP2K6 | 0.62006273 |
| 105 | GRK5 | 0.61957662 |
| 106 | WNK3 | 0.60970835 |
| 107 | PIK3CA | 0.60267605 |
| 108 | PLK1 | 0.59138166 |
| 109 | RAF1 | 0.58934620 |
| 110 | CAMK2B | 0.58437525 |
| 111 | GRK1 | 0.58091987 |
| 112 | ZAK | 0.56993127 |
| 113 | PRKCG | 0.56859518 |
| 114 | DAPK1 | 0.56774863 |
| 115 | TIE1 | 0.56742143 |
| 116 | STK16 | 0.56335195 |
| 117 | IKBKE | 0.56012781 |
| 118 | PDPK1 | 0.55973058 |
| 119 | OXSR1 | 0.54712445 |
| 120 | MAP3K12 | 0.54522051 |
| 121 | RPS6KA3 | 0.53943556 |
| 122 | ROCK1 | 0.53290981 |
| 123 | CAMK2G | 0.52757118 |
| 124 | ACVR1B | 0.52530432 |
| 125 | MAPK12 | 0.52085711 |
| 126 | UHMK1 | 0.51883221 |
| 127 | PLK2 | 0.51248830 |
| 128 | PRKACA | 0.50756783 |
| 129 | ERBB3 | 0.50380308 |
| 130 | PRKCZ | 0.50321752 |
| 131 | PRKD1 | 0.49057007 |
| 132 | PRKACG | 0.48349672 |
| 133 | NEK6 | 0.48156849 |
| 134 | TAOK1 | 0.47916829 |
| 135 | LATS1 | 0.47227662 |
| 136 | NUAK1 | 0.47174794 |
| 137 | ABL2 | 0.46800582 |
| 138 | PLK3 | 0.46793968 |
| 139 | MAP3K2 | 0.45848537 |
| 140 | BUB1 | 0.45597492 |
| 141 | NEK9 | 0.45163581 |
| 142 | PRKCQ | 0.44602134 |
| 143 | MAP3K1 | 0.43402895 |
| 144 | IKBKB | 0.43372453 |
| 145 | TYRO3 | 0.41453339 |
| 146 | ATM | 0.41226723 |
| 147 | TSSK6 | 0.40414784 |
| 148 | PRKCB | 0.40356687 |
| 149 | CAMK1G | 0.40258249 |
| 150 | TEC | 0.36585185 |
| 151 | ERBB4 | 0.36569224 |
| 152 | ATR | 0.35813367 |
| 153 | MAP4K2 | 0.33582212 |
| 154 | BRSK1 | 0.31873380 |
| 155 | MKNK2 | 0.30054490 |
| 156 | IRAK3 | 0.29591033 |
| 157 | MAPKAPK5 | 0.28626482 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.87463573 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 2.85052962 |
| 3 | Morphine addiction_Homo sapiens_hsa05032 | 2.59896697 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.55457023 |
| 5 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.41771453 |
| 6 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.33832426 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.33737918 |
| 8 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 2.29812891 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.27495397 |
| 10 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 2.22633402 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.22524634 |
| 12 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.22050781 |
| 13 | Long-term potentiation_Homo sapiens_hsa04720 | 2.18468987 |
| 14 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.12503225 |
| 15 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 2.04512690 |
| 16 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.00108214 |
| 17 | Salivary secretion_Homo sapiens_hsa04970 | 1.90791257 |
| 18 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.89403404 |
| 19 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.86785408 |
| 20 | Renin secretion_Homo sapiens_hsa04924 | 1.86618984 |
| 21 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.86244563 |
| 22 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.82267682 |
| 23 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.81471889 |
| 24 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 1.79577531 |
| 25 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.78661324 |
| 26 | Taste transduction_Homo sapiens_hsa04742 | 1.77171652 |
| 27 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.76961603 |
| 28 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.76755558 |
| 29 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.75180746 |
| 30 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.73874538 |
| 31 | Insulin secretion_Homo sapiens_hsa04911 | 1.72817527 |
| 32 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.71729461 |
| 33 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.70448927 |
| 34 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.70447290 |
| 35 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.62558815 |
| 36 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.62299907 |
| 37 | Cocaine addiction_Homo sapiens_hsa05030 | 1.56999895 |
| 38 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.49999476 |
| 39 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.46764941 |
| 40 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.45317020 |
| 41 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.45288744 |
| 42 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.45214402 |
| 43 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.37899879 |
| 44 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.37573511 |
| 45 | Long-term depression_Homo sapiens_hsa04730 | 1.35323569 |
| 46 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.35240954 |
| 47 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.26810802 |
| 48 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.26770628 |
| 49 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.26320729 |
| 50 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.25954586 |
| 51 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.25518319 |
| 52 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.24555120 |
| 53 | Mismatch repair_Homo sapiens_hsa03430 | 1.22905259 |
| 54 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.22289270 |
| 55 | Phototransduction_Homo sapiens_hsa04744 | 1.19881443 |
| 56 | Tryptophan metabolism_Homo sapiens_hsa00380 | 1.18359186 |
| 57 | DNA replication_Homo sapiens_hsa03030 | 1.17661715 |
| 58 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.17529364 |
| 59 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.14782253 |
| 60 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.13757191 |
| 61 | Gap junction_Homo sapiens_hsa04540 | 1.10085551 |
| 62 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.09304184 |
| 63 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.08504555 |
| 64 | Carbon metabolism_Homo sapiens_hsa01200 | 1.00079526 |
| 65 | Basal transcription factors_Homo sapiens_hsa03022 | 0.99948917 |
| 66 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.98225194 |
| 67 | RNA degradation_Homo sapiens_hsa03018 | 0.97702799 |
| 68 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.95942479 |
| 69 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.95622092 |
| 70 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.93522381 |
| 71 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.92955732 |
| 72 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.92366800 |
| 73 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.91695765 |
| 74 | Melanoma_Homo sapiens_hsa05218 | 0.88937104 |
| 75 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.88438776 |
| 76 | Histidine metabolism_Homo sapiens_hsa00340 | 0.87255961 |
| 77 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.86968757 |
| 78 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.85417027 |
| 79 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.84344148 |
| 80 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.84220189 |
| 81 | Parkinsons disease_Homo sapiens_hsa05012 | 0.82778772 |
| 82 | ABC transporters_Homo sapiens_hsa02010 | 0.81425435 |
| 83 | Circadian rhythm_Homo sapiens_hsa04710 | 0.80128220 |
| 84 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.79692843 |
| 85 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.79546842 |
| 86 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.79512800 |
| 87 | Retinol metabolism_Homo sapiens_hsa00830 | 0.76627082 |
| 88 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.75056750 |
| 89 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.74562943 |
| 90 | Alzheimers disease_Homo sapiens_hsa05010 | 0.73607817 |
| 91 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.73536993 |
| 92 | Glioma_Homo sapiens_hsa05214 | 0.70365183 |
| 93 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.69374153 |
| 94 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.68983357 |
| 95 | RNA polymerase_Homo sapiens_hsa03020 | 0.68569312 |
| 96 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.67875228 |
| 97 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.66749255 |
| 98 | Melanogenesis_Homo sapiens_hsa04916 | 0.65492116 |
| 99 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.65098524 |
| 100 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.64898280 |
| 101 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.64757204 |
| 102 | Peroxisome_Homo sapiens_hsa04146 | 0.64581504 |
| 103 | Protein export_Homo sapiens_hsa03060 | 0.64233334 |
| 104 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.63371615 |
| 105 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.62725488 |
| 106 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.62468745 |
| 107 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.62321724 |
| 108 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.62253398 |
| 109 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.60961547 |
| 110 | RNA transport_Homo sapiens_hsa03013 | 0.60755908 |
| 111 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.60379570 |
| 112 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.59991053 |
| 113 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.59217646 |
| 114 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.59163038 |
| 115 | Mineral absorption_Homo sapiens_hsa04978 | 0.58957161 |
| 116 | Metabolic pathways_Homo sapiens_hsa01100 | 0.58627919 |
| 117 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.56593555 |
| 118 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.55827707 |
| 119 | Axon guidance_Homo sapiens_hsa04360 | 0.54618147 |
| 120 | Cell cycle_Homo sapiens_hsa04110 | 0.54587077 |
| 121 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.52550738 |
| 122 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.52396166 |
| 123 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.50998567 |
| 124 | Purine metabolism_Homo sapiens_hsa00230 | 0.50609623 |
| 125 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.50361073 |
| 126 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.49947010 |
| 127 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.49560084 |
| 128 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.49513201 |
| 129 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.49450157 |
| 130 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.49024448 |
| 131 | Viral myocarditis_Homo sapiens_hsa05416 | 0.48931326 |
| 132 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.48384233 |
| 133 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.48283908 |
| 134 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.47708102 |
| 135 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.47643673 |
| 136 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.46920823 |
| 137 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.46909307 |
| 138 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.46060282 |
| 139 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.44257723 |
| 140 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.44158323 |
| 141 | Insulin resistance_Homo sapiens_hsa04931 | 0.43900744 |
| 142 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.42798416 |
| 143 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.42346246 |
| 144 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.40699171 |
| 145 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.40261082 |
| 146 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.37829105 |
| 147 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.37486481 |
| 148 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.35800022 |
| 149 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.34991105 |
| 150 | Sulfur relay system_Homo sapiens_hsa04122 | 0.34517549 |
| 151 | Huntingtons disease_Homo sapiens_hsa05016 | 0.34167993 |
| 152 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.34012150 |
| 153 | Platelet activation_Homo sapiens_hsa04611 | 0.33941590 |
| 154 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.33639398 |
| 155 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.33540880 |
| 156 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.33299823 |
| 157 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.31559273 |
| 158 | Endometrial cancer_Homo sapiens_hsa05213 | 0.29802927 |
| 159 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.28551294 |
| 160 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.28537576 |
| 161 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.27304005 |
| 162 | Alcoholism_Homo sapiens_hsa05034 | 0.26408274 |
| 163 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.25027448 |

