STRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)5.57447054
2axon ensheathment in central nervous system (GO:0032291)5.57447054
3nuclear pore complex assembly (GO:0051292)5.56408060
4negative regulation of neurotransmitter secretion (GO:0046929)5.04678455
5nuclear pore organization (GO:0006999)4.55029163
6negative regulation of neurotransmitter transport (GO:0051589)4.51941042
7presynaptic membrane assembly (GO:0097105)4.42301468
8myelination (GO:0042552)4.29450944
9ensheathment of neurons (GO:0007272)4.22661891
10axon ensheathment (GO:0008366)4.22661891
11presynaptic membrane organization (GO:0097090)4.18215270
12synaptic transmission, dopaminergic (GO:0001963)4.04727901
13regulation of RNA export from nucleus (GO:0046831)4.00977022
14long-chain fatty acid biosynthetic process (GO:0042759)3.93815884
15positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.92974977
16pore complex assembly (GO:0046931)3.92877674
17bundle of His cell to Purkinje myocyte communication (GO:0086069)3.90892985
18negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.85809292
19regulation of nucleobase-containing compound transport (GO:0032239)3.79011934
20embryonic process involved in female pregnancy (GO:0060136)3.65331729
21peripheral nervous system axon ensheathment (GO:0032292)3.59677155
22myelination in peripheral nervous system (GO:0022011)3.59677155
23prepulse inhibition (GO:0060134)3.58790576
24cytoplasmic mRNA processing body assembly (GO:0033962)3.55228745
25glycerophospholipid catabolic process (GO:0046475)3.54931910
26behavioral response to cocaine (GO:0048148)3.54016003
27cyclic nucleotide catabolic process (GO:0009214)3.51927968
28transmission of nerve impulse (GO:0019226)3.50982524
29negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.48841438
30hypotonic response (GO:0006971)3.48280702
31fatty acid elongation (GO:0030497)3.47581678
32regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.46225548
33regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.46225548
34regulation of neurotransmitter uptake (GO:0051580)3.44944935
35negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.43182323
36striatum development (GO:0021756)3.39706323
37desmosome organization (GO:0002934)3.35696465
38neurotransmitter-gated ion channel clustering (GO:0072578)3.33756787
39neuron cell-cell adhesion (GO:0007158)3.33427519
40negative regulation of potassium ion transmembrane transport (GO:1901380)3.33167760
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.32802668
42astrocyte development (GO:0014002)3.29645191
43mitotic sister chromatid cohesion (GO:0007064)3.28867019
44regulation of establishment of cell polarity (GO:2000114)3.26957951
45neuron-neuron synaptic transmission (GO:0007270)3.26300504
46adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.23970137
47neuronal action potential propagation (GO:0019227)3.17675350
48histone H3-K36 demethylation (GO:0070544)3.13618600
49peptidyl-threonine modification (GO:0018210)3.12703094
50peptidyl-threonine phosphorylation (GO:0018107)3.11634662
51pre-miRNA processing (GO:0031054)3.09115687
52negative regulation of protein localization to cell surface (GO:2000009)3.08663761
53focal adhesion assembly (GO:0048041)3.05889144
54cell-substrate adherens junction assembly (GO:0007045)3.05889144
55response to redox state (GO:0051775)3.05501500
56negative regulation of DNA repair (GO:0045738)3.05204779
57ionotropic glutamate receptor signaling pathway (GO:0035235)3.02619981
58regulation of NFAT protein import into nucleus (GO:0051532)3.02553430
59regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.00095774
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.00023158
61cAMP catabolic process (GO:0006198)2.98575853
62cell-substrate junction assembly (GO:0007044)2.98157152
63cerebellar granule cell differentiation (GO:0021707)2.96837551
64synaptic transmission, glutamatergic (GO:0035249)2.96556489
65cerebral cortex radially oriented cell migration (GO:0021799)2.96113834
66adult walking behavior (GO:0007628)2.93656210
67negative regulation of myotube differentiation (GO:0010832)2.93335910
68phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89202737
69L-amino acid import (GO:0043092)2.86549858
70adherens junction assembly (GO:0034333)2.85718186
71positive regulation of neurological system process (GO:0031646)2.84117956
72regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83536659
73negative regulation of synaptic transmission (GO:0050805)2.82723988
74regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82007981
75histone H3-K9 demethylation (GO:0033169)2.78763768
76negative regulation of erythrocyte differentiation (GO:0045647)2.78464627
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77691068
78positive regulation of action potential (GO:0045760)2.77533940
79regulation of synaptic transmission, GABAergic (GO:0032228)2.77383670
80myelin maintenance (GO:0043217)2.76299658
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73653416
82response to amphetamine (GO:0001975)2.73415268
83protein localization to endosome (GO:0036010)2.73028583
84positive regulation of membrane potential (GO:0045838)2.72456036
85regulation of dendritic spine morphogenesis (GO:0061001)2.72430907
86eye photoreceptor cell differentiation (GO:0001754)2.72411810
87photoreceptor cell differentiation (GO:0046530)2.72411810
88glutamate receptor signaling pathway (GO:0007215)2.71760992
89G-protein coupled receptor internalization (GO:0002031)2.71089168
90oligodendrocyte differentiation (GO:0048709)2.70983202
91apical protein localization (GO:0045176)2.70660339
92mitotic chromosome condensation (GO:0007076)2.70127938
93positive regulation of meiosis (GO:0045836)2.69798592
94visual learning (GO:0008542)2.69194486
95vocalization behavior (GO:0071625)2.68740898
96regulation of synaptic transmission, glutamatergic (GO:0051966)2.68452719
97cortical actin cytoskeleton organization (GO:0030866)2.68021498
98RNA stabilization (GO:0043489)2.67948384
99mRNA stabilization (GO:0048255)2.67948384
100regulation of histone H3-K27 methylation (GO:0061085)2.67682896
101regulation of synaptic vesicle exocytosis (GO:2000300)2.67405367
102positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.67306734
103regulation of glutamate secretion (GO:0014048)2.65709552
104regulation of voltage-gated calcium channel activity (GO:1901385)2.65452277
105membrane assembly (GO:0071709)2.65375758
106cardiac myofibril assembly (GO:0055003)2.64919162
107cellular response to gamma radiation (GO:0071480)2.64173940
108neuronal ion channel clustering (GO:0045161)2.64044973
109positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.63154391
110protein K11-linked deubiquitination (GO:0035871)2.60990326
111substrate-independent telencephalic tangential migration (GO:0021826)2.60820218
112substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.60820218
113regulation of dendritic spine development (GO:0060998)2.60414056
114monoubiquitinated protein deubiquitination (GO:0035520)2.60206229
115synaptic vesicle maturation (GO:0016188)2.59204530
116regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58307840
117auditory behavior (GO:0031223)2.57865071
118regulation of myelination (GO:0031641)2.57772716
119response to histamine (GO:0034776)2.56512016
120negative regulation of macroautophagy (GO:0016242)2.56376188
121long-term synaptic potentiation (GO:0060291)2.56048569
122NLS-bearing protein import into nucleus (GO:0006607)2.55241616
123regulation of collateral sprouting (GO:0048670)2.55009064
124locomotory exploration behavior (GO:0035641)2.54539767
125nerve growth factor signaling pathway (GO:0038180)2.54145973
126microtubule polymerization or depolymerization (GO:0031109)2.53476947
127histone lysine demethylation (GO:0070076)2.52012488
128regulation of postsynaptic membrane potential (GO:0060078)2.51733576
129regulation of glutamate receptor signaling pathway (GO:1900449)2.50874692
130negative regulation of dendrite morphogenesis (GO:0050774)2.50868448
131visual behavior (GO:0007632)2.50443989
132myofibril assembly (GO:0030239)2.50342454
133regulation of neuronal synaptic plasticity (GO:0048168)2.49663954
134interkinetic nuclear migration (GO:0022027)2.49531303
135positive regulation of meiotic cell cycle (GO:0051446)2.49140172
136dendritic spine organization (GO:0097061)2.47835657
137asymmetric protein localization (GO:0008105)2.47715525
138regulation of exit from mitosis (GO:0007096)2.46905296
139protein localization to synapse (GO:0035418)2.46699933
140iron ion import (GO:0097286)2.46496734
141dendritic spine morphogenesis (GO:0060997)2.46396475
142mechanosensory behavior (GO:0007638)2.46029338
143epithelial cell-cell adhesion (GO:0090136)2.45930825
144hemidesmosome assembly (GO:0031581)2.45781144
145definitive hemopoiesis (GO:0060216)2.43799618
146embryonic camera-type eye morphogenesis (GO:0048596)2.43651374
147negative regulation of histone methylation (GO:0031061)2.42866747
148sarcomere organization (GO:0045214)2.42115377
149cellular protein complex localization (GO:0034629)2.41212391
150DNA unwinding involved in DNA replication (GO:0006268)2.40461581
151regulation of necroptotic process (GO:0060544)2.39155296
152regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.36257661
153histone demethylation (GO:0016577)2.35313802
154response to laminar fluid shear stress (GO:0034616)2.34828512
155cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.34162657
156ventricular cardiac muscle cell action potential (GO:0086005)2.34110863
157cortical cytoskeleton organization (GO:0030865)2.33050877
158protein export from nucleus (GO:0006611)2.32873417
159coronary vasculature morphogenesis (GO:0060977)2.31870653
160cellular response to epinephrine stimulus (GO:0071872)2.31842282
161epithelial cell differentiation involved in prostate gland development (GO:0060742)2.29109430
162trophectodermal cell differentiation (GO:0001829)2.28579233
163cardiac muscle hypertrophy (GO:0003300)2.27794806
164cardiac muscle contraction (GO:0060048)2.27534571
165regulation of early endosome to late endosome transport (GO:2000641)2.27194376
166keratinization (GO:0031424)2.26021307
167cell communication by electrical coupling (GO:0010644)2.25719607
168cell communication involved in cardiac conduction (GO:0086065)2.25347052
169mRNA transcription (GO:0009299)2.24885564
170regulation of transforming growth factor beta2 production (GO:0032909)2.24587624
171positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.24418767
172positive regulation of Rap GTPase activity (GO:0032854)2.23928168
173positive regulation of receptor recycling (GO:0001921)2.22335007
174response to epidermal growth factor (GO:0070849)2.22079003
1753-UTR-mediated mRNA stabilization (GO:0070935)2.21792188
176positive regulation of protein export from nucleus (GO:0046827)2.21718144
177positive regulation of cellular response to insulin stimulus (GO:1900078)2.21301824
178hippo signaling (GO:0035329)2.20613303
179embryonic eye morphogenesis (GO:0048048)2.20277610
180clathrin coat assembly (GO:0048268)2.19459935
181positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.19343012
182establishment of skin barrier (GO:0061436)2.18090631
183negative regulation of necroptotic process (GO:0060546)2.17441912
184negative regulation of vascular permeability (GO:0043116)2.17264379
185regulation of water loss via skin (GO:0033561)2.16778146
186cellular response to osmotic stress (GO:0071470)2.16324990
187regulation of histone H3-K9 methylation (GO:0051570)2.16066915
188glucocorticoid receptor signaling pathway (GO:0042921)2.14897585
189regulation of protein polyubiquitination (GO:1902914)2.14124838
190negative regulation of striated muscle cell differentiation (GO:0051154)2.13017631
191protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.12905510
192import into cell (GO:0098657)2.12873631
193phospholipid translocation (GO:0045332)2.12725909
194lipid translocation (GO:0034204)2.12725909
195dosage compensation (GO:0007549)2.12381630
196cellular hyperosmotic response (GO:0071474)2.10845051
197gap junction assembly (GO:0016264)2.10793043
198negative regulation of anoikis (GO:2000811)2.10737874
199regulation of ARF protein signal transduction (GO:0032012)2.10697603
200actin filament-based movement (GO:0030048)2.10600813

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.52079898
2GBX2_23144817_ChIP-Seq_PC3_Human3.98618065
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.69569833
4E2F7_22180533_ChIP-Seq_HELA_Human3.56253808
5TP63_17297297_ChIP-ChIP_HaCaT_Human2.88364636
6GATA1_22025678_ChIP-Seq_K562_Human2.81203920
7EZH2_22144423_ChIP-Seq_EOC_Human2.78333658
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75298771
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.66378826
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.56261215
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35521472
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29715428
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.27223961
14TAF15_26573619_Chip-Seq_HEK293_Human2.23850264
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22597927
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21293969
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.18365675
18JARID2_20064375_ChIP-Seq_MESCs_Mouse2.06583397
19* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05753573
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04061094
21FOXM1_23109430_ChIP-Seq_U2OS_Human2.02574668
22AR_21572438_ChIP-Seq_LNCaP_Human2.01440076
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01059502
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.98169012
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96893731
26CLOCK_20551151_ChIP-Seq_293T_Human1.94111454
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.89767092
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.89268607
29TCF7_22412390_ChIP-Seq_EML_Mouse1.88201366
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.88045755
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84290862
32WT1_19549856_ChIP-ChIP_CCG9911_Human1.83947291
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82070977
34P300_19829295_ChIP-Seq_ESCs_Human1.80528551
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80229915
36SMAD4_21799915_ChIP-Seq_A2780_Human1.80191088
37FUS_26573619_Chip-Seq_HEK293_Human1.79020333
38MYC_22102868_ChIP-Seq_BL_Human1.77805908
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77586043
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.77220214
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.77220214
42* RARB_27405468_Chip-Seq_BRAIN_Mouse1.76414277
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76299798
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75592053
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.74188010
46* STAT3_23295773_ChIP-Seq_U87_Human1.74099803
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.73601370
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.72396250
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.71874718
50* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.71779365
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.70317161
52CTNNB1_20460455_ChIP-Seq_HCT116_Human1.69319391
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.69167462
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.63359299
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62912601
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.62792112
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62333636
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61665216
59SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.61300025
60SCL_19346495_ChIP-Seq_HPC-7_Human1.60657646
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59132228
62ER_23166858_ChIP-Seq_MCF-7_Human1.57888589
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.57648410
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.57567131
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56846090
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56805140
67* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56310574
68TCF4_23295773_ChIP-Seq_U87_Human1.55629927
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.55312590
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55039307
71AR_21909140_ChIP-Seq_LNCAP_Human1.53948007
72* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53391976
73* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.53136127
74* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.53136127
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.52347308
76SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.52312632
77RNF2_27304074_Chip-Seq_NSC_Mouse1.50131829
78GATA1_19941826_ChIP-Seq_K562_Human1.49890563
79STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49299439
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48828153
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.46722032
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46565975
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45298151
84ZNF217_24962896_ChIP-Seq_MCF-7_Human1.44814931
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44729709
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.43754201
87TBX20_22080862_ChIP-Seq_HEART_Mouse1.42584170
88TBX20_22328084_ChIP-Seq_HEART_Mouse1.42584170
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42529090
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42506430
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.42184430
92E2F1_18555785_Chip-Seq_ESCs_Mouse1.42073908
93ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41794248
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41123639
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40414107
96P300_27058665_Chip-Seq_ZR-75-30cells_Human1.40048910
97KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39972777
98TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39806550
99GATA2_21666600_ChIP-Seq_HMVEC_Human1.39407135
100GATA2_19941826_ChIP-Seq_K562_Human1.39388759
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39235273
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.39169854
103EWS_26573619_Chip-Seq_HEK293_Human1.38107179
104BRD4_27068464_Chip-Seq_AML-cells_Mouse1.38097161
105DROSHA_22980978_ChIP-Seq_HELA_Human1.37555875
106LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35638401
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35433154
108EED_16625203_ChIP-ChIP_MESCs_Mouse1.35305571
109PRDM14_20953172_ChIP-Seq_ESCs_Human1.34181436
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34088734
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.33746094
112CMYC_18555785_Chip-Seq_ESCs_Mouse1.33446012
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.33018825
114SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32786021
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32392326
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.32272469
117VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32204281
118TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31654702
119P53_22387025_ChIP-Seq_ESCs_Mouse1.30684844
120KDM2B_26808549_Chip-Seq_K562_Human1.30097332
121SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29968653
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29760368
123POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29760368
124CBX2_27304074_Chip-Seq_ESCs_Mouse1.28545024
125AR_25329375_ChIP-Seq_VCAP_Human1.28534821
126REST_21632747_ChIP-Seq_MESCs_Mouse1.28327896
127* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28045795
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27659372
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27057822
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26957925
131EZH2_27294783_Chip-Seq_ESCs_Mouse1.25187794
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24920052
133TP53_16413492_ChIP-PET_HCT116_Human1.24542324
134KDM2B_26808549_Chip-Seq_DND41_Human1.24472416
135PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24361247
136IGF1R_20145208_ChIP-Seq_DFB_Human1.23966592
137TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23480025
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.23291873
139* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23047913
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22887124
141NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.22880085
142P300_18555785_Chip-Seq_ESCs_Mouse1.22617755
143UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22559566
144RUNX_20019798_ChIP-Seq_JUKART_Human1.21908233
145RUNX2_22187159_ChIP-Seq_PCA_Human1.20847838
146BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20101894
147KDM2B_26808549_Chip-Seq_JURKAT_Human1.19690460
148RXR_22108803_ChIP-Seq_LS180_Human1.19539488
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.18908211
150SOX2_18555785_Chip-Seq_ESCs_Mouse1.18904951
151* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.18456301
152BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18280555
153VDR_22108803_ChIP-Seq_LS180_Human1.18013622
154EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17724987
155NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16976318
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16430944
157TCF4_18268006_ChIP-ChIP_LS174T_Human1.16242052
158SOX2_21211035_ChIP-Seq_LN229_Gbm1.15901720
159NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15678004
160SPI1_23127762_ChIP-Seq_K562_Human1.15415269
161RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14764586
162* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.14085936
163NFE2_27457419_Chip-Seq_LIVER_Mouse1.13858988
164RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13306682
165TBL1_22424771_ChIP-Seq_293T_Human1.12454347
166AHR_22903824_ChIP-Seq_MCF-7_Human1.12323665
167NMYC_18555785_Chip-Seq_ESCs_Mouse1.12151774
168GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11578560
169JUN_21703547_ChIP-Seq_K562_Human1.10964137
170LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10729959
171NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09825725
172EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09367828
173* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09323524
174ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08345070
175PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06518654
176SALL1_21062744_ChIP-ChIP_HESCs_Human1.04752407
177IRF8_27001747_Chip-Seq_BMDM_Mouse1.04690931
178* PU_27001747_Chip-Seq_BMDM_Mouse1.04226596
179GATA1_19941827_ChIP-Seq_MEL_Mouse1.03458970
180GATA1_19941827_ChIP-Seq_MEL86_Mouse1.01303715
181YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99968171
182ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99354035
183RUNX1_27514584_Chip-Seq_MCF-7_Human0.98361517
184NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97007760
185UBF1/2_26484160_Chip-Seq_HMECs_Human0.93275430
186NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92366276
187* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91809294
188* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91392711

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.23786096
2MP0004859_abnormal_synaptic_plasticity3.83771641
3MP0002822_catalepsy3.71037729
4MP0003705_abnormal_hypodermis_morpholog3.55740168
5MP0005451_abnormal_body_composition3.40800486
6MP0010352_gastrointestinal_tract_polyps3.26737494
7MP0004270_analgesia3.25464133
8MP0003950_abnormal_plasma_membrane3.09768026
9MP0005646_abnormal_pituitary_gland3.03322440
10MP0001486_abnormal_startle_reflex3.01445016
11MP0001529_abnormal_vocalization3.00329585
12MP0010234_abnormal_vibrissa_follicle3.00112868
13MP0000920_abnormal_myelination2.99001810
14MP0008057_abnormal_DNA_replication2.95688616
15MP0002877_abnormal_melanocyte_morpholog2.94625334
16MP0004084_abnormal_cardiac_muscle2.87986687
17MP0002009_preneoplasia2.84473516
18MP0003566_abnormal_cell_adhesion2.66064041
19MP0005171_absent_coat_pigmentation2.65203134
20MP0003635_abnormal_synaptic_transmissio2.61968896
21MP0009745_abnormal_behavioral_response2.60060282
22MP0005076_abnormal_cell_differentiation2.41663857
23MP0002272_abnormal_nervous_system2.35747866
24MP0009046_muscle_twitch2.34139054
25MP0002796_impaired_skin_barrier2.32783290
26MP0002063_abnormal_learning/memory/cond2.26261317
27MP0001485_abnormal_pinna_reflex2.22963789
28MP0001905_abnormal_dopamine_level2.19586485
29MP0003828_pulmonary_edema2.18453504
30MP0004885_abnormal_endolymph2.17846516
31MP0003941_abnormal_skin_development2.17015870
32MP0002064_seizures2.15993247
33MP0004742_abnormal_vestibular_system2.13541525
34MP0004185_abnormal_adipocyte_glucose2.12033343
35MP0003300_gastrointestinal_ulcer2.10750648
36MP0003787_abnormal_imprinting2.09904684
37MP0002572_abnormal_emotion/affect_behav2.06709700
38MP0005409_darkened_coat_color1.97560952
39MP0003091_abnormal_cell_migration1.96243175
40MP0004233_abnormal_muscle_weight1.95281517
41MP0003453_abnormal_keratinocyte_physiol1.92528047
42MP0004924_abnormal_behavior1.89238016
43MP0005386_behavior/neurological_phenoty1.89238016
44MP0010630_abnormal_cardiac_muscle1.87852574
45MP0001188_hyperpigmentation1.86509878
46MP0005275_abnormal_skin_tensile1.86264124
47MP0002734_abnormal_mechanical_nocicepti1.85993384
48MP0002396_abnormal_hematopoietic_system1.84465637
49MP0001968_abnormal_touch/_nociception1.81006057
50MP0003690_abnormal_glial_cell1.80459162
51MP0004264_abnormal_extraembryonic_tissu1.78217088
52MP0000778_abnormal_nervous_system1.76954363
53MP0005423_abnormal_somatic_nervous1.76368439
54MP0003136_yellow_coat_color1.73469166
55MP0003221_abnormal_cardiomyocyte_apopto1.68455569
56MP0006138_congestive_heart_failure1.60472560
57MP0004087_abnormal_muscle_fiber1.60355636
58MP0000566_synostosis1.57558060
59MP0008877_abnormal_DNA_methylation1.55842140
60MP0001986_abnormal_taste_sensitivity1.54814271
61MP0004808_abnormal_hematopoietic_stem1.54206921
62MP0003656_abnormal_erythrocyte_physiolo1.50033873
63MP0002067_abnormal_sensory_capabilities1.47066611
64MP0001440_abnormal_grooming_behavior1.46486322
65MP0003632_abnormal_nervous_system1.43288861
66MP0005666_abnormal_adipose_tissue1.42312506
67MP0003984_embryonic_growth_retardation1.39232938
68MP0001177_atelectasis1.38661418
69MP0002166_altered_tumor_susceptibility1.36232342
70MP0004947_skin_inflammation1.36059939
71MP0008569_lethality_at_weaning1.35209891
72MP0001915_intracranial_hemorrhage1.34267439
73MP0002088_abnormal_embryonic_growth/wei1.33784044
74MP0004130_abnormal_muscle_cell1.31493530
75MP0002736_abnormal_nociception_after1.29935097
76MP0006292_abnormal_olfactory_placode1.29594932
77MP0002229_neurodegeneration1.28874247
78MP0002086_abnormal_extraembryonic_tissu1.28015580
79MP0003191_abnormal_cellular_cholesterol1.27857759
80MP0003303_peritoneal_inflammation1.24491678
81MP0008260_abnormal_autophagy1.24043563
82MP0001970_abnormal_pain_threshold1.23788642
83MP0005501_abnormal_skin_physiology1.23162389
84MP0010307_abnormal_tumor_latency1.23128095
85MP0005408_hypopigmentation1.22957297
86MP0003634_abnormal_glial_cell1.18937799
87MP0001672_abnormal_embryogenesis/_devel1.18634642
88MP0005380_embryogenesis_phenotype1.18634642
89MP0002882_abnormal_neuron_morphology1.17651412
90MP0004510_myositis1.16774825
91MP0004484_altered_response_of1.16094641
92MP0005023_abnormal_wound_healing1.15488309
93MP0003937_abnormal_limbs/digits/tail_de1.15226142
94MP0001346_abnormal_lacrimal_gland1.14140977
95MP0001730_embryonic_growth_arrest1.14100084
96MP0004272_abnormal_basement_membrane1.13129391
97MP0005645_abnormal_hypothalamus_physiol1.13051002
98MP0003763_abnormal_thymus_physiology1.12428158
99MP0002735_abnormal_chemical_nociception1.11639205
100MP0000955_abnormal_spinal_cord1.09963026
101MP0002066_abnormal_motor_capabilities/c1.09737263
102MP0005375_adipose_tissue_phenotype1.09002670
103MP0005621_abnormal_cell_physiology1.08473811
104MP0002557_abnormal_social/conspecific_i1.08292042
105MP0004142_abnormal_muscle_tone1.07653262
106MP0001963_abnormal_hearing_physiology1.07575417
107MP0009697_abnormal_copulation1.07198504
108MP0000751_myopathy1.06999729
109MP0008438_abnormal_cutaneous_collagen1.04819781
110MP0009672_abnormal_birth_weight1.04671978
111MP0000733_abnormal_muscle_development1.04517965
112MP0002972_abnormal_cardiac_muscle1.04374851
113MP0001984_abnormal_olfaction1.04268367
114MP0003045_fibrosis1.02233420
115MP0000428_abnormal_craniofacial_morphol1.01724339
116MP0003631_nervous_system_phenotype1.01046900
117MP0002733_abnormal_thermal_nociception1.00432073
118MP0005310_abnormal_salivary_gland0.99694027
119MP0003718_maternal_effect0.99521441
120MP0000631_abnormal_neuroendocrine_gland0.99386090
121MP0000350_abnormal_cell_proliferation0.98516704
122MP0010678_abnormal_skin_adnexa0.98447055
123MP0005330_cardiomyopathy0.98371379
124MP0002269_muscular_atrophy0.98210447
125MP0004215_abnormal_myocardial_fiber0.97296161
126MP0000569_abnormal_digit_pigmentation0.97225487
127MP0002060_abnormal_skin_morphology0.97218042
128MP0000747_muscle_weakness0.96518773
129MP0003879_abnormal_hair_cell0.96198776
130MP0001849_ear_inflammation0.95777321
131MP0002925_abnormal_cardiovascular_devel0.95422596
132MP0001216_abnormal_epidermal_layer0.94236048
133MP0001502_abnormal_circadian_rhythm0.93636317
134MP0000377_abnormal_hair_follicle0.93131763
135MP0004957_abnormal_blastocyst_morpholog0.91760211
136MP0010368_abnormal_lymphatic_system0.91499357
137MP0002006_tumorigenesis0.91467196
138MP0000759_abnormal_skeletal_muscle0.89605924
139MP0008004_abnormal_stomach_pH0.88676179
140MP0003890_abnormal_embryonic-extraembry0.88545487
141MP0000767_abnormal_smooth_muscle0.87814533
142MP0004085_abnormal_heartbeat0.87718128
143MP0002184_abnormal_innervation0.87269684
144MP0002152_abnormal_brain_morphology0.86684727
145MP0002102_abnormal_ear_morphology0.86176006
146MP0001544_abnormal_cardiovascular_syste0.86044757
147MP0005385_cardiovascular_system_phenoty0.86044757
148MP0001784_abnormal_fluid_regulation0.85807428
149MP0002752_abnormal_somatic_nervous0.85771139
150MP0002998_abnormal_bone_remodeling0.85606559
151MP0004147_increased_porphyrin_level0.84588304
152MP0001299_abnormal_eye_distance/0.84035851
153MP0004036_abnormal_muscle_relaxation0.83628018
154MP0004134_abnormal_chest_morphology0.82960085
155MP0001697_abnormal_embryo_size0.80985195
156MP0000003_abnormal_adipose_tissue0.80047639
157MP0001501_abnormal_sleep_pattern0.80018788
158MP0000015_abnormal_ear_pigmentation0.79716788
159MP0000383_abnormal_hair_follicle0.79686852
160MP0009115_abnormal_fat_cell0.79561258
161MP0000266_abnormal_heart_morphology0.79063702
162MP0003938_abnormal_ear_development0.79063317
163MP0002080_prenatal_lethality0.77432484
164MP0004811_abnormal_neuron_physiology0.76789718
165MP0000858_altered_metastatic_potential0.76682506
166MP0000465_gastrointestinal_hemorrhage0.76589975
167MP0009703_decreased_birth_body0.73856212
168MP0000749_muscle_degeneration0.73836011
169MP0005464_abnormal_platelet_physiology0.73470926
170MP0002128_abnormal_blood_circulation0.73293613
171MP0005248_abnormal_Harderian_gland0.73151878
172MP0002127_abnormal_cardiovascular_syste0.72723043
173MP0000372_irregular_coat_pigmentation0.72640165
174MP0004197_abnormal_fetal_growth/weight/0.72452543
175MP0002896_abnormal_bone_mineralization0.72434572
176MP0003121_genomic_imprinting0.71488868
177MP0009250_abnormal_appendicular_skeleto0.69417199
178MP0000639_abnormal_adrenal_gland0.68599721
179MP0005551_abnormal_eye_electrophysiolog0.65932933
180MP0003633_abnormal_nervous_system0.64995196
181MP0005377_hearing/vestibular/ear_phenot0.64387398
182MP0003878_abnormal_ear_physiology0.64387398
183MP0001851_eye_inflammation0.63939034
184MP0008874_decreased_physiological_sensi0.62239939
185MP0000026_abnormal_inner_ear0.61927731
186MP0003698_abnormal_male_reproductive0.59668620
187MP0000579_abnormal_nail_morphology0.59141147
188MP0002210_abnormal_sex_determination0.58926554
189MP0003329_amyloid_beta_deposits0.58863474

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.74305830
2Degeneration of the lateral corticospinal tracts (HP:0002314)4.74305830
3Sensory axonal neuropathy (HP:0003390)4.69098704
4Focal motor seizures (HP:0011153)4.51100295
5Parakeratosis (HP:0001036)4.31874686
6Myokymia (HP:0002411)4.07306558
7Right ventricular cardiomyopathy (HP:0011663)3.92635946
8Abnormality of the corticospinal tract (HP:0002492)3.68622465
9Abnormal auditory evoked potentials (HP:0006958)3.53755757
10Papillary thyroid carcinoma (HP:0002895)3.36965076
11Gaze-evoked nystagmus (HP:0000640)3.32626015
12Termporal pattern (HP:0011008)3.27250062
13Insidious onset (HP:0003587)3.27250062
14Atonic seizures (HP:0010819)3.24215890
15Dysmetric saccades (HP:0000641)3.21535858
16Ankyloglossia (HP:0010296)2.97385223
17Peripheral hypomyelination (HP:0007182)2.96560211
18Dysmetria (HP:0001310)2.93331905
19Abnormality of the left ventricular outflow tract (HP:0011103)2.82851181
20Subaortic stenosis (HP:0001682)2.82851181
21Adrenal hypoplasia (HP:0000835)2.82495692
22Ventricular tachycardia (HP:0004756)2.80290926
23Abnormality of the fingertips (HP:0001211)2.76734469
24Scanning speech (HP:0002168)2.75118912
25Fetal akinesia sequence (HP:0001989)2.70981920
26Broad-based gait (HP:0002136)2.70664127
27Hyporeflexia of lower limbs (HP:0002600)2.70022258
28Onion bulb formation (HP:0003383)2.59255203
29Abnormality of chromosome segregation (HP:0002916)2.57482823
30Epileptic encephalopathy (HP:0200134)2.57132247
31Akinesia (HP:0002304)2.54598028
32Thickened helices (HP:0000391)2.53937632
33Urinary bladder sphincter dysfunction (HP:0002839)2.50561251
34Abnormality of the labia minora (HP:0012880)2.48558704
35Absent/shortened dynein arms (HP:0200106)2.47609144
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.47609144
37Centrally nucleated skeletal muscle fibers (HP:0003687)2.46175375
38Subacute progressive viral hepatitis (HP:0006572)2.45501629
39Abnormality of nail color (HP:0100643)2.45264616
40Abnormality of incisor morphology (HP:0011063)2.42888437
41Spastic gait (HP:0002064)2.41688804
42Sudden death (HP:0001699)2.39812619
43Abnormal hair whorl (HP:0010721)2.39712930
44Slow saccadic eye movements (HP:0000514)2.38923810
45Bundle branch block (HP:0011710)2.38324212
46Focal seizures (HP:0007359)2.37352931
47Aplasia involving bones of the upper limbs (HP:0009823)2.36928006
48Aplasia of the phalanges of the hand (HP:0009802)2.36928006
49Aplasia involving bones of the extremities (HP:0009825)2.36928006
50Cerebral hypomyelination (HP:0006808)2.34692909
51Absent eyebrow (HP:0002223)2.32886193
52Intention tremor (HP:0002080)2.32800432
53Hyperventilation (HP:0002883)2.32400808
54Abnormality of oral frenula (HP:0000190)2.31116532
55Difficulty running (HP:0009046)2.30284877
56Arterial tortuosity (HP:0005116)2.30088819
57Curly hair (HP:0002212)2.28345453
58Flat acetabular roof (HP:0003180)2.27934941
59Nonprogressive disorder (HP:0003680)2.25698880
60Increased connective tissue (HP:0009025)2.25013655
61Thyroid carcinoma (HP:0002890)2.24823626
62White forelock (HP:0002211)2.24747555
63Progressive cerebellar ataxia (HP:0002073)2.24690183
64Aqueductal stenosis (HP:0002410)2.24073755
65Distal lower limb amyotrophy (HP:0008944)2.22931653
66Acute myeloid leukemia (HP:0004808)2.22643083
67Deep philtrum (HP:0002002)2.21558284
68Hypoplastic pelvis (HP:0008839)2.21376665
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.19223320
70Osteolytic defects of the hand bones (HP:0009699)2.19223320
71Midline defect of the nose (HP:0004122)2.16968655
72Febrile seizures (HP:0002373)2.16461754
73Ectopic kidney (HP:0000086)2.13963689
74Patchy hypopigmentation of hair (HP:0011365)2.13703382
75Progressive inability to walk (HP:0002505)2.13536078
76Vertebral arch anomaly (HP:0008438)2.11492400
77Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09267291
78Action tremor (HP:0002345)2.08059987
79Heterotopia (HP:0002282)2.07281040
80Dysdiadochokinesis (HP:0002075)2.06889671
81Absent septum pellucidum (HP:0001331)2.06529712
82Chromsome breakage (HP:0040012)2.05115768
83Relative macrocephaly (HP:0004482)2.04495985
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.04433462
85Widely spaced teeth (HP:0000687)2.04163661
86Neurofibrillary tangles (HP:0002185)2.03657126
87Lower limb amyotrophy (HP:0007210)2.00139075
88Genital tract atresia (HP:0001827)1.99745361
89Abnormality of the salivary glands (HP:0010286)1.99408253
90Autoamputation (HP:0001218)1.98737420
91Mitral valve prolapse (HP:0001634)1.97724903
92Syringomyelia (HP:0003396)1.97365618
93Spinal cord lesions (HP:0100561)1.97365618
94Vascular tortuosity (HP:0004948)1.97014772
95Morphological abnormality of the inner ear (HP:0011390)1.96679615
96Overgrowth (HP:0001548)1.96360224
97Lower limb muscle weakness (HP:0007340)1.94113923
98Vaginal atresia (HP:0000148)1.93922171
99Spontaneous hematomas (HP:0007420)1.93628531
100Blue irides (HP:0000635)1.93504528
101Generalized myoclonic seizures (HP:0002123)1.93453237
102Eczematoid dermatitis (HP:0000976)1.92464197
103Cubitus valgus (HP:0002967)1.92441002
104Abnormality of the distal phalanx of the thumb (HP:0009617)1.91280871
105Annular pancreas (HP:0001734)1.91229012
106Asymmetry of the thorax (HP:0001555)1.91068152
107Absent speech (HP:0001344)1.88050260
108Atrial fibrillation (HP:0005110)1.87477056
109Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.87353725
110Steppage gait (HP:0003376)1.87328693
111Bowel incontinence (HP:0002607)1.85208604
112Abnormality of the septum pellucidum (HP:0007375)1.84318739
113Intellectual disability, moderate (HP:0002342)1.84048388
114Pheochromocytoma (HP:0002666)1.83944803
115Ectropion (HP:0000656)1.83710948
116Cupped ear (HP:0000378)1.82639655
117Muscle fiber splitting (HP:0003555)1.82399381
118Gastrointestinal carcinoma (HP:0002672)1.80892233
119Malignant gastrointestinal tract tumors (HP:0006749)1.80892233
120Neonatal hypoglycemia (HP:0001998)1.78959536
121Ankle clonus (HP:0011448)1.76921637
122Coarse hair (HP:0002208)1.75903272
123Cystic hygroma (HP:0000476)1.75614427
124Macroorchidism (HP:0000053)1.74687129
125Esophageal varix (HP:0002040)1.73844949
126Disproportionate tall stature (HP:0001519)1.73412638
127Abnormality of skeletal muscle fiber size (HP:0012084)1.73382696
128Increased variability in muscle fiber diameter (HP:0003557)1.72798166
129Narrow palate (HP:0000189)1.72254653
130Uterine leiomyosarcoma (HP:0002891)1.72178813
131Leiomyosarcoma (HP:0100243)1.72178813
132Distal lower limb muscle weakness (HP:0009053)1.70781512
133Genetic anticipation (HP:0003743)1.70594260
134Abnormal large intestine physiology (HP:0012700)1.69967967
135Atrioventricular block (HP:0001678)1.69681986
136Impaired vibration sensation in the lower limbs (HP:0002166)1.69392663
137Exercise-induced myalgia (HP:0003738)1.69272429
138Increased IgE level (HP:0003212)1.68744902
139Cerebral aneurysm (HP:0004944)1.67011973
140Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.67004187
141Foot dorsiflexor weakness (HP:0009027)1.66980501
142Abnormal ciliary motility (HP:0012262)1.66453258
143Prostate neoplasm (HP:0100787)1.66101520
144Torticollis (HP:0000473)1.65907378
145Aneurysm (HP:0002617)1.64987467
146Hammertoe (HP:0001765)1.64874957
147Poor coordination (HP:0002370)1.64517987
148Gait imbalance (HP:0002141)1.64273697
149Primary atrial arrhythmia (HP:0001692)1.63731574
150Medial flaring of the eyebrow (HP:0010747)1.63727938
151Follicular hyperkeratosis (HP:0007502)1.63110064
152Thick nail (HP:0001805)1.63087495
153Metaphyseal cupping (HP:0003021)1.62140501
154Transitional cell carcinoma of the bladder (HP:0006740)1.61864163
155Abnormal respiratory motile cilium physiology (HP:0012261)1.61685410
156EMG: neuropathic changes (HP:0003445)1.60998522
157Long eyelashes (HP:0000527)1.60922988
158Persistence of primary teeth (HP:0006335)1.60275368
159Ulnar claw (HP:0001178)1.60249470
160Decreased motor nerve conduction velocity (HP:0003431)1.60189421
161Male infertility (HP:0003251)1.59648487
162Polycythemia (HP:0001901)1.58760050
163Aortic aneurysm (HP:0004942)1.58122883
164Segmental peripheral demyelination/remyelination (HP:0003481)1.57621900
165Bladder neoplasm (HP:0009725)1.57418370
166Bladder carcinoma (HP:0002862)1.57418370
167Hypoplasia of the iris (HP:0007676)1.57360661
168Nephrogenic diabetes insipidus (HP:0009806)1.57122539
169Abnormality of the foot musculature (HP:0001436)1.57105012
170EMG: myopathic abnormalities (HP:0003458)1.56486737
171Neuroendocrine neoplasm (HP:0100634)1.56390662
172Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.56262112
173Pulmonic stenosis (HP:0001642)1.55351950
174Advanced eruption of teeth (HP:0006288)1.55012800
175Increased mean platelet volume (HP:0011877)1.53935400
176Abnormality of the nasal septum (HP:0000419)1.53589379
177Poor speech (HP:0002465)1.53475905
178Sandal gap (HP:0001852)1.53457562
179Abnormal lung lobation (HP:0002101)1.53326493
180Resting tremor (HP:0002322)1.52791782
181Dislocated radial head (HP:0003083)1.52671589
182Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.52434947
183Congenital primary aphakia (HP:0007707)1.52310540
184Abnormality of saccadic eye movements (HP:0000570)1.52292080
185Dilatation of the ascending aorta (HP:0005111)1.49213778
186Myocardial infarction (HP:0001658)1.49058903
187Fatigue (HP:0012378)1.48024408
188Abnormal platelet volume (HP:0011876)1.47850238
189Germ cell neoplasia (HP:0100728)1.47200539
190Biliary tract neoplasm (HP:0100574)1.47168130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B5.06561249
2LATS14.06848808
3CDK123.92023111
4EPHA43.36271634
5CASK3.20937669
6EEF2K2.84301965
7STK392.79346238
8SIK32.61780050
9TNIK2.50973944
10BCR2.45995340
11OXSR12.43359856
12STK38L2.42948793
13MUSK2.24741026
14ICK2.16416231
15TTN2.16083273
16PDGFRA2.11661713
17TRIB32.09621541
18MAP3K102.07488314
19NEK61.92997065
20LATS21.90803166
21MAP3K21.83339896
22SGK2231.77463391
23SGK4941.77463391
24RIPK11.72212295
25FGFR31.71775589
26FGFR41.69557576
27BRD41.65981138
28SCYL21.64079666
29ERBB41.62225109
30SGK21.55777302
31MAP2K71.54677434
32PAK61.49475494
33NEK91.46477800
34MAPK131.37469611
35NTRK31.37006008
36PKN21.36204935
37PKN11.31661809
38MAP3K41.29720774
39MAP2K31.29526693
40CAMK1G1.27250738
41WNK11.26416108
42BMPR21.24764667
43MAP3K141.22974176
44RET1.20766188
45NUAK11.18732317
46MAP3K131.18471332
47MTOR1.16416373
48FGFR21.15284024
49CAMK1D1.15048590
50RPS6KB21.14735022
51MAP3K61.13831585
52YES11.13128020
53PLK21.12450661
54SGK31.12230268
55CDK191.11488991
56CDK61.09081267
57JAK11.07663112
58STK31.07174595
59SMG11.06334200
60TYRO31.04689170
61MET1.00866846
62KSR20.99355760
63AKT30.98335026
64PRKD30.97183830
65EPHB10.95040476
66PLK40.94855543
67KSR10.92597649
68MARK30.92102895
69CSNK1G10.89637431
70TAOK10.84867162
71MAP3K10.84385716
72BRAF0.83536762
73PIK3CG0.83388928
74CSK0.81502204
75CLK10.80919715
76CDK80.80858521
77MINK10.78901303
78MAPK120.78853791
79CAMK2B0.77247884
80MAP3K70.77206502
81CAMK2A0.77135129
82MAP3K90.76392539
83NTRK20.74927451
84MAPKAPK50.74594709
85STK380.74572507
86CSNK1G20.73607193
87MARK20.73117524
88ZAP700.72542002
89JAK20.72410462
90CDK50.72344580
91JAK30.71697402
92CDC42BPA0.70683178
93BMX0.70340821
94CDC70.69235427
95NLK0.69106812
96TRPM70.67382033
97SGK10.66866550
98BLK0.64909142
99CSNK1A1L0.64286601
100CDK30.63941809
101DMPK0.63302814
102RAF10.62697731
103MST1R0.62451456
104CSNK1G30.62354844
105STK240.61668285
106OBSCN0.61575420
107FGFR10.61013826
108CAMKK20.60867802
109CDK40.60828512
110PRKCH0.60474358
111ROCK20.60342434
112ADRBK20.59248798
113ALK0.58674973
114MKNK20.58235745
115CDK180.58184985
116BMPR1B0.57625393
117STK40.57206194
118FES0.56241759
119IRAK30.56234143
120ARAF0.56173906
121MELK0.56170259
122CAMK2D0.56056471
123SRPK10.55085283
124MAPK70.53994046
125SIK10.52952705
126TGFBR20.52787539
127PDPK10.51717468
128PTK20.51329406
129MAP3K30.50642935
130RPS6KB10.50072290
131UHMK10.48833182
132CDK140.48241325
133PRKAA20.48067232
134NTRK10.47515782
135MAPK100.47391420
136PIK3CA0.47333269
137CSNK1D0.47223475
138CHEK20.47098815
139PDK10.46765417
140CDK150.46641510
141MAP3K80.45222887
142PRKCQ0.45020333
143MAP3K50.44994773
144PRKCE0.44754302
145MARK10.44414827
146FGR0.44373722
147CAMK40.44149483
148PTK60.44043897
149VRK10.43223921
150PDGFRB0.41689267
151STK110.41581803
152HCK0.41377728
153TTK0.40009705
154LIMK10.38464716
155IRAK20.38323330
156RIPK40.38148301
157PINK10.38055331
158BTK0.37741823
159RPS6KC10.37467324
160RPS6KL10.37467324
161CSNK1A10.37034459
162DAPK20.36694073
163TNK20.36102464
164CDK11A0.35275579

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.33186825
2Morphine addiction_Homo sapiens_hsa050322.24107766
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.23011084
4Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15125190
5Nicotine addiction_Homo sapiens_hsa050332.13399203
6Glutamatergic synapse_Homo sapiens_hsa047242.13173827
7Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.08402687
8Chronic myeloid leukemia_Homo sapiens_hsa052202.07470923
9Ether lipid metabolism_Homo sapiens_hsa005652.01572695
10Circadian entrainment_Homo sapiens_hsa047131.95036503
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93773440
12Serotonergic synapse_Homo sapiens_hsa047261.91512145
13Adherens junction_Homo sapiens_hsa045201.85199512
14Long-term depression_Homo sapiens_hsa047301.82470295
15Axon guidance_Homo sapiens_hsa043601.80693726
16Long-term potentiation_Homo sapiens_hsa047201.80271206
17Steroid biosynthesis_Homo sapiens_hsa001001.79176379
18Dopaminergic synapse_Homo sapiens_hsa047281.78033387
19GABAergic synapse_Homo sapiens_hsa047271.77473294
20Cocaine addiction_Homo sapiens_hsa050301.67701133
21Acute myeloid leukemia_Homo sapiens_hsa052211.66416601
22Amphetamine addiction_Homo sapiens_hsa050311.65372246
23Cholinergic synapse_Homo sapiens_hsa047251.59780859
24Sphingolipid metabolism_Homo sapiens_hsa006001.59460311
25B cell receptor signaling pathway_Homo sapiens_hsa046621.58290908
26Synaptic vesicle cycle_Homo sapiens_hsa047211.52634715
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.50013563
28Ovarian steroidogenesis_Homo sapiens_hsa049131.47466203
29VEGF signaling pathway_Homo sapiens_hsa043701.45763682
30AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.45680872
31ErbB signaling pathway_Homo sapiens_hsa040121.41460552
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38946814
33Focal adhesion_Homo sapiens_hsa045101.37645129
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.34761120
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.33929587
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33662161
37Salivary secretion_Homo sapiens_hsa049701.31969833
38Basal transcription factors_Homo sapiens_hsa030221.31719222
39Vitamin B6 metabolism_Homo sapiens_hsa007501.30812426
40Renal cell carcinoma_Homo sapiens_hsa052111.29926849
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.28634804
42Fatty acid elongation_Homo sapiens_hsa000621.28505900
43Colorectal cancer_Homo sapiens_hsa052101.27641885
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27386458
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26033336
46cAMP signaling pathway_Homo sapiens_hsa040241.24668013
47Proteoglycans in cancer_Homo sapiens_hsa052051.24574257
48Small cell lung cancer_Homo sapiens_hsa052221.22764550
49mTOR signaling pathway_Homo sapiens_hsa041501.22531732
50Oxytocin signaling pathway_Homo sapiens_hsa049211.21793788
51Ras signaling pathway_Homo sapiens_hsa040141.21775428
52Central carbon metabolism in cancer_Homo sapiens_hsa052301.19942961
53Prolactin signaling pathway_Homo sapiens_hsa049171.19010999
54Calcium signaling pathway_Homo sapiens_hsa040201.17650373
55Gap junction_Homo sapiens_hsa045401.17550793
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.15947178
57Insulin signaling pathway_Homo sapiens_hsa049101.15676883
58Phospholipase D signaling pathway_Homo sapiens_hsa040721.15436247
59Renin secretion_Homo sapiens_hsa049241.14816857
60Amoebiasis_Homo sapiens_hsa051461.13753315
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12089834
62Dorso-ventral axis formation_Homo sapiens_hsa043201.11306876
63Taste transduction_Homo sapiens_hsa047421.11093704
64GnRH signaling pathway_Homo sapiens_hsa049121.10846362
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08909195
66Phototransduction_Homo sapiens_hsa047441.07909043
67Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06981698
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06393930
69Choline metabolism in cancer_Homo sapiens_hsa052311.04153363
70Sphingolipid signaling pathway_Homo sapiens_hsa040711.02232944
71Bladder cancer_Homo sapiens_hsa052191.00168670
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99799004
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99436241
74Osteoclast differentiation_Homo sapiens_hsa043800.99165823
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98723929
76Oocyte meiosis_Homo sapiens_hsa041140.98460748
77Gastric acid secretion_Homo sapiens_hsa049710.97601159
78T cell receptor signaling pathway_Homo sapiens_hsa046600.95532478
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95116484
80Non-small cell lung cancer_Homo sapiens_hsa052230.94719902
81Hepatitis B_Homo sapiens_hsa051610.93886033
82ECM-receptor interaction_Homo sapiens_hsa045120.91450878
83HIF-1 signaling pathway_Homo sapiens_hsa040660.89938743
84Circadian rhythm_Homo sapiens_hsa047100.89375260
85Insulin resistance_Homo sapiens_hsa049310.89024442
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86051802
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84669798
88Tight junction_Homo sapiens_hsa045300.84478456
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84382234
90MAPK signaling pathway_Homo sapiens_hsa040100.84343240
91Inositol phosphate metabolism_Homo sapiens_hsa005620.83248739
92Hepatitis C_Homo sapiens_hsa051600.83224584
93Viral carcinogenesis_Homo sapiens_hsa052030.83216168
94Dilated cardiomyopathy_Homo sapiens_hsa054140.80477516
95Glioma_Homo sapiens_hsa052140.79324919
96Chemokine signaling pathway_Homo sapiens_hsa040620.77602043
97Notch signaling pathway_Homo sapiens_hsa043300.76549532
98Toxoplasmosis_Homo sapiens_hsa051450.76337031
99Lysine degradation_Homo sapiens_hsa003100.76212195
100Wnt signaling pathway_Homo sapiens_hsa043100.74458190
101Rap1 signaling pathway_Homo sapiens_hsa040150.74292003
102Pathways in cancer_Homo sapiens_hsa052000.73947263
103Melanogenesis_Homo sapiens_hsa049160.73604717
104AMPK signaling pathway_Homo sapiens_hsa041520.73336135
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.72439642
106Measles_Homo sapiens_hsa051620.71894755
107Insulin secretion_Homo sapiens_hsa049110.70026633
108Pancreatic cancer_Homo sapiens_hsa052120.69605557
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69390308
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69082791
111TNF signaling pathway_Homo sapiens_hsa046680.69074906
112Apoptosis_Homo sapiens_hsa042100.67920117
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67303851
114Type II diabetes mellitus_Homo sapiens_hsa049300.66975781
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66182739
116Endometrial cancer_Homo sapiens_hsa052130.65850888
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65685279
118Leishmaniasis_Homo sapiens_hsa051400.64468084
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64370458
120Endocytosis_Homo sapiens_hsa041440.63329308
121Influenza A_Homo sapiens_hsa051640.63216404
122Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63002996
123Prion diseases_Homo sapiens_hsa050200.62305173
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61466302
125Melanoma_Homo sapiens_hsa052180.60694990
126Collecting duct acid secretion_Homo sapiens_hsa049660.60606672
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60469042
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.60417829
129Thyroid cancer_Homo sapiens_hsa052160.59353768
130mRNA surveillance pathway_Homo sapiens_hsa030150.57712722
131Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57349049
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56073644
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.53323162
134Linoleic acid metabolism_Homo sapiens_hsa005910.52443332
135Platelet activation_Homo sapiens_hsa046110.52369224
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51868265
137Hippo signaling pathway_Homo sapiens_hsa043900.51017599
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51010344
139MicroRNAs in cancer_Homo sapiens_hsa052060.50921025
140Malaria_Homo sapiens_hsa051440.50879409
141Glucagon signaling pathway_Homo sapiens_hsa049220.50543415
142alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49584484
143Non-homologous end-joining_Homo sapiens_hsa034500.49009512
144Estrogen signaling pathway_Homo sapiens_hsa049150.48993625
145Prostate cancer_Homo sapiens_hsa052150.47178156
146TGF-beta signaling pathway_Homo sapiens_hsa043500.46642869
147RNA degradation_Homo sapiens_hsa030180.46310260
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45677505
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42433853
150Alcoholism_Homo sapiens_hsa050340.41901917
151Rheumatoid arthritis_Homo sapiens_hsa053230.41664062
152Cell cycle_Homo sapiens_hsa041100.40824860
153FoxO signaling pathway_Homo sapiens_hsa040680.40580877
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40231408
155Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39609671
156Hedgehog signaling pathway_Homo sapiens_hsa043400.37389204

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