STRN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)4.20890982
2regulation of hexokinase activity (GO:1903299)4.13154887
3regulation of glucokinase activity (GO:0033131)4.13154887
4protein K6-linked ubiquitination (GO:0085020)3.69091356
5cornea development in camera-type eye (GO:0061303)3.67845105
6keratinocyte development (GO:0003334)3.65461073
7synapsis (GO:0007129)3.62818255
8negative regulation of protein localization to cell surface (GO:2000009)3.55762001
9DNA double-strand break processing (GO:0000729)3.52291426
10lateral sprouting from an epithelium (GO:0060601)3.51351918
11positive regulation of protein autophosphorylation (GO:0031954)3.34997416
12kidney morphogenesis (GO:0060993)3.24972159
13prenylation (GO:0097354)3.23269044
14protein prenylation (GO:0018342)3.23269044
15lactate metabolic process (GO:0006089)3.22025811
16response to pheromone (GO:0019236)3.21143225
17respiratory chain complex IV assembly (GO:0008535)3.20758731
18DNA deamination (GO:0045006)3.19053099
19fucose catabolic process (GO:0019317)3.16739942
20L-fucose metabolic process (GO:0042354)3.16739942
21L-fucose catabolic process (GO:0042355)3.16739942
22dorsal/ventral axis specification (GO:0009950)3.15550683
23neuron remodeling (GO:0016322)3.11766982
24lymph vessel development (GO:0001945)3.08993507
25limb bud formation (GO:0060174)3.08212066
26negative regulation of JUN kinase activity (GO:0043508)3.06511147
27inositol phosphate catabolic process (GO:0071545)3.06328106
28negative regulation of neurotransmitter transport (GO:0051589)3.06063096
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.05240769
30presynaptic membrane assembly (GO:0097105)3.03915920
31replication fork processing (GO:0031297)3.03354112
32regulation of cell communication by electrical coupling (GO:0010649)3.02194883
33negative regulation of neurotransmitter secretion (GO:0046929)2.99642657
34positive regulation of glycoprotein biosynthetic process (GO:0010560)2.95808614
35actin-myosin filament sliding (GO:0033275)2.90396150
36muscle filament sliding (GO:0030049)2.90396150
37cerebral cortex radially oriented cell migration (GO:0021799)2.89989425
38branched-chain amino acid catabolic process (GO:0009083)2.87390039
39prostate gland growth (GO:0060736)2.86523745
40axonal fasciculation (GO:0007413)2.83899255
41positive regulation of glycolytic process (GO:0045821)2.83578852
42axon ensheathment in central nervous system (GO:0032291)2.83406325
43central nervous system myelination (GO:0022010)2.83406325
44platelet dense granule organization (GO:0060155)2.82593516
45sarcoplasmic reticulum calcium ion transport (GO:0070296)2.82499906
46actin-mediated cell contraction (GO:0070252)2.80397002
47negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.79302778
48somite development (GO:0061053)2.78117389
49regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.76661974
50phosphorylated carbohydrate dephosphorylation (GO:0046838)2.76175952
51inositol phosphate dephosphorylation (GO:0046855)2.76175952
52cytochrome complex assembly (GO:0017004)2.76048176
53chondrocyte proliferation (GO:0035988)2.74675679
54regulation of meiosis I (GO:0060631)2.74383405
55RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74364064
56negative regulation of activin receptor signaling pathway (GO:0032926)2.74160409
57atrial cardiac muscle cell action potential (GO:0086014)2.74121350
58neuron recognition (GO:0008038)2.73796205
59somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.72693474
60somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.72693474
61isotype switching (GO:0045190)2.72693474
62kidney mesenchyme development (GO:0072074)2.72059723
63polyol catabolic process (GO:0046174)2.71273505
64positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.71042867
65neuron cell-cell adhesion (GO:0007158)2.71030431
66metanephric mesenchyme development (GO:0072075)2.69421596
67detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.68701250
68hindbrain development (GO:0030902)2.68198914
69regulation of mesoderm development (GO:2000380)2.67737422
70single strand break repair (GO:0000012)2.67585080
71regulation of type B pancreatic cell apoptotic process (GO:2000674)2.67434070
72signal transduction involved in regulation of gene expression (GO:0023019)2.65945202
73cellular ketone body metabolic process (GO:0046950)2.65855240
74positive regulation of cardiac muscle cell differentiation (GO:2000727)2.65499455
75positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.64599642
76establishment of protein localization to Golgi (GO:0072600)2.63799111
77chondrocyte development (GO:0002063)2.63412791
78presynaptic membrane organization (GO:0097090)2.62168957
79negative regulation of neurological system process (GO:0031645)2.62115828
80protein targeting to Golgi (GO:0000042)2.60126913
81somite rostral/caudal axis specification (GO:0032525)2.59791318
82cullin deneddylation (GO:0010388)2.57979808
83gonadal mesoderm development (GO:0007506)2.55381476
84pancreas development (GO:0031016)2.54950682
85cilium morphogenesis (GO:0060271)2.54238650
86transepithelial transport (GO:0070633)2.52867205
87cranial nerve morphogenesis (GO:0021602)2.51316273
88preassembly of GPI anchor in ER membrane (GO:0016254)2.49509797
89kynurenine metabolic process (GO:0070189)2.49166152
90dendrite morphogenesis (GO:0048813)2.48893163
91regulation of skeletal muscle contraction (GO:0014819)2.48794249
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47922140
93transmission of nerve impulse (GO:0019226)2.47804853
94regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.47226291
95membrane assembly (GO:0071709)2.46746275
96neuronal action potential propagation (GO:0019227)2.45336903
97plasma membrane repair (GO:0001778)2.45169222
98female gonad development (GO:0008585)2.44187688
99ketone body metabolic process (GO:1902224)2.44003949
100embryonic foregut morphogenesis (GO:0048617)2.43924395
101regulation of glomerulus development (GO:0090192)2.43885548
102positive regulation of meiosis (GO:0045836)2.43835369
103apical protein localization (GO:0045176)2.42612103
104proteasome assembly (GO:0043248)2.42483571
105myelination in peripheral nervous system (GO:0022011)2.42122699
106peripheral nervous system axon ensheathment (GO:0032292)2.42122699
107histone H2A acetylation (GO:0043968)2.41061685
108regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.38784126
109tryptophan catabolic process (GO:0006569)2.38595311
110indole-containing compound catabolic process (GO:0042436)2.38595311
111indolalkylamine catabolic process (GO:0046218)2.38595311
112negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.37722097
113retina layer formation (GO:0010842)2.37688152
114intestinal epithelial cell development (GO:0060576)2.37527899
115regulation of axon extension involved in axon guidance (GO:0048841)2.36664753
116regulation of protein glycosylation (GO:0060049)2.36393779
117mesodermal cell differentiation (GO:0048333)2.36351262
118protein K11-linked deubiquitination (GO:0035871)2.36318604
119piRNA metabolic process (GO:0034587)2.35561569
120glomerulus development (GO:0032835)2.35538102
121regulation of nuclear cell cycle DNA replication (GO:0033262)2.34895376
122signal peptide processing (GO:0006465)2.34715038
123protein complex biogenesis (GO:0070271)2.34681780
124regulation of protein autophosphorylation (GO:0031952)2.34374504
125organ formation (GO:0048645)2.34188966
126negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33951282
127regulation of sulfur metabolic process (GO:0042762)2.33481501
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.32501165
129zinc ion transport (GO:0006829)2.32464597
130regulation of dendritic spine morphogenesis (GO:0061001)2.32084321
131double-strand break repair via homologous recombination (GO:0000724)2.32075895
132recombinational repair (GO:0000725)2.31884190
133positive regulation of meiotic cell cycle (GO:0051446)2.31770824
134regulation of DNA endoreduplication (GO:0032875)2.31748263
135neural tube formation (GO:0001841)2.31526183
136regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.31368446
137histone exchange (GO:0043486)2.31349593
138neural crest cell development (GO:0014032)2.31219062
139retina vasculature morphogenesis in camera-type eye (GO:0061299)2.31191273
140protein deneddylation (GO:0000338)2.30574352
141endocrine pancreas development (GO:0031018)2.30562071
142muscle cell fate commitment (GO:0042693)2.30235249
143protein localization to cilium (GO:0061512)2.29504462
144protein localization to Golgi apparatus (GO:0034067)2.29493006
145skeletal muscle fiber development (GO:0048741)2.29059902
146appendage development (GO:0048736)2.28960103
147limb development (GO:0060173)2.28960103
148regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.28869887
149middle ear morphogenesis (GO:0042474)2.28052597
150embryonic epithelial tube formation (GO:0001838)2.27918750
151myelination (GO:0042552)2.27846532
152gland morphogenesis (GO:0022612)2.26991711
153skeletal muscle contraction (GO:0003009)2.26956995
154regulation of timing of cell differentiation (GO:0048505)2.26794683
155definitive hemopoiesis (GO:0060216)2.26455437
156dermatan sulfate biosynthetic process (GO:0030208)2.26085156
157reflex (GO:0060004)2.25893600
158parental behavior (GO:0060746)2.25534520
159indolalkylamine metabolic process (GO:0006586)2.25261105
160DNA replication-dependent nucleosome organization (GO:0034723)2.25201333
161DNA replication-dependent nucleosome assembly (GO:0006335)2.25201333
162smooth muscle cell differentiation (GO:0051145)2.25172008
163reciprocal meiotic recombination (GO:0007131)2.24748230
164reciprocal DNA recombination (GO:0035825)2.24748230
165negative regulation of axon extension (GO:0030517)2.24582770
166negative regulation of axon extension involved in axon guidance (GO:0048843)2.24397653
167anatomical structure arrangement (GO:0048532)2.24043327
168asymmetric protein localization (GO:0008105)2.23764025
169response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.23508850
170protein targeting to lysosome (GO:0006622)2.22429316
171establishment of protein localization to vacuole (GO:0072666)2.22429316
172protein targeting to vacuole (GO:0006623)2.22429316
173positive regulation of glomerulus development (GO:0090193)2.21629115
174sequestering of extracellular ligand from receptor (GO:0035581)2.21564253
175ensheathment of neurons (GO:0007272)2.19979782
176axon ensheathment (GO:0008366)2.19979782
177regulation of relaxation of muscle (GO:1901077)2.19792457
178regulation of actin filament-based movement (GO:1903115)2.19513160
179regulation of sarcomere organization (GO:0060297)2.18825299
180negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.18701448
181regulation of synapse assembly (GO:0051963)2.17844368
182myofibril assembly (GO:0030239)2.17364207
183regulation of axon guidance (GO:1902667)2.17210542
184regulation of mesenchymal cell proliferation (GO:0010464)2.16762278
185cell differentiation involved in kidney development (GO:0061005)2.16327025
186mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.16092956
187cellular response to BMP stimulus (GO:0071773)2.14445573
188response to BMP (GO:0071772)2.14445573
189actin filament-based movement (GO:0030048)2.14380657
190positive regulation of potassium ion transport (GO:0043268)2.14170592
191mesenchymal cell differentiation involved in renal system development (GO:2001012)2.13922141
192mesenchymal cell differentiation involved in kidney development (GO:0072161)2.13922141
193myotube cell development (GO:0014904)2.13863504
194positive regulation of male gonad development (GO:2000020)2.12968393
195neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.12778575
196mesenchymal cell differentiation (GO:0048762)2.12460473
197eye photoreceptor cell differentiation (GO:0001754)2.11289270
198photoreceptor cell differentiation (GO:0046530)2.11289270

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.19172179
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.91293852
3EZH2_22144423_ChIP-Seq_EOC_Human2.51931236
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49530124
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45319821
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40445531
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38780834
8TAF15_26573619_Chip-Seq_HEK293_Human2.35030439
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.32055860
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26072504
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20653255
12FUS_26573619_Chip-Seq_HEK293_Human2.12747378
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.11980256
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.11889712
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.10482247
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.09326464
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.05814710
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.01394605
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.01362221
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00443243
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00443243
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98265626
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.95213396
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90975869
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.89837002
26P300_19829295_ChIP-Seq_ESCs_Human1.89686552
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.89005856
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87196253
29* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86739599
30SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.86590886
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86335336
32IGF1R_20145208_ChIP-Seq_DFB_Human1.83284087
33AR_21572438_ChIP-Seq_LNCaP_Human1.83111612
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.77328000
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72968247
36EWS_26573619_Chip-Seq_HEK293_Human1.71226553
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71042245
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.70145317
39SMAD4_21799915_ChIP-Seq_A2780_Human1.70028237
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68931862
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.68625722
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.67849579
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66819232
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65442991
45JARID2_20075857_ChIP-Seq_MESCs_Mouse1.63832071
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63010944
47RNF2_27304074_Chip-Seq_ESCs_Mouse1.62406381
48TP53_16413492_ChIP-PET_HCT116_Human1.61539338
49* ZNF274_21170338_ChIP-Seq_K562_Hela1.61441726
50ER_23166858_ChIP-Seq_MCF-7_Human1.60144597
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58536715
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56712461
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56134054
54ELK1_19687146_ChIP-ChIP_HELA_Human1.55238070
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.54920399
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53311624
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52115944
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51443222
59CBP_20019798_ChIP-Seq_JUKART_Human1.51443222
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.51390235
61MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51283700
62TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50156490
63HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49708353
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.49124770
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.48192021
66NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.48192021
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47265034
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46800404
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44769478
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.43530656
71TP53_18474530_ChIP-ChIP_U2OS_Human1.42720184
72ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42180901
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.40977045
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.38972257
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38298926
76NANOG_19829295_ChIP-Seq_ESCs_Human1.38213449
77SOX2_19829295_ChIP-Seq_ESCs_Human1.38213449
78STAT3_23295773_ChIP-Seq_U87_Human1.36979794
79* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36289077
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36198876
81CDX2_22108803_ChIP-Seq_LS180_Human1.36054147
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.33496001
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.33374557
84TCF4_22108803_ChIP-Seq_LS180_Human1.33374497
85SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.33010717
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32563335
87AHR_22903824_ChIP-Seq_MCF-7_Human1.32314969
88EST1_17652178_ChIP-ChIP_JURKAT_Human1.31910405
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31712473
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30932957
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.29696698
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28177960
93PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27548674
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.27264865
95BCAT_22108803_ChIP-Seq_LS180_Human1.26488394
96* TP53_22573176_ChIP-Seq_HFKS_Human1.25972932
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25839745
98RNF2_27304074_Chip-Seq_NSC_Mouse1.24705824
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.24044673
100SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.23691111
101* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23132914
102CJUN_26792858_Chip-Seq_BT549_Human1.21936010
103NANOG_18555785_Chip-Seq_ESCs_Mouse1.20811210
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19939806
105MYC_18940864_ChIP-ChIP_HL60_Human1.19265942
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18876185
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.18389692
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.18032888
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17498390
110TCF4_23295773_ChIP-Seq_U87_Human1.16511623
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.16415113
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16310819
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16199404
114RUNX2_22187159_ChIP-Seq_PCA_Human1.15696509
115CMYC_18555785_Chip-Seq_ESCs_Mouse1.15664057
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15412499
117TCF4_18268006_ChIP-ChIP_LS174T_Human1.15150447
118P300_18555785_Chip-Seq_ESCs_Mouse1.14446607
119TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14216833
120NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14155211
121AR_25329375_ChIP-Seq_VCAP_Human1.13991434
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12497576
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12079530
124VDR_22108803_ChIP-Seq_LS180_Human1.11756528
125OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11681417
126TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11646747
127SOX2_21211035_ChIP-Seq_LN229_Gbm1.11222058
128YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09818242
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09672582
130PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09470467
131WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.08621631
132SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08042048
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07569056
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07566811
135* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06165025
136RING1B_27294783_Chip-Seq_NPCs_Mouse1.05870113
137* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05717970
138ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05601006
139EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05015085
140PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04274280
141SOX2_18555785_Chip-Seq_ESCs_Mouse1.03427066
142OCT4_18555785_Chip-Seq_ESCs_Mouse1.03182465
143FOXA1_27270436_Chip-Seq_PROSTATE_Human1.02808548
144FOXA1_25329375_ChIP-Seq_VCAP_Human1.02808548
145P53_22387025_ChIP-Seq_ESCs_Mouse1.02281927
146HTT_18923047_ChIP-ChIP_STHdh_Human1.01900056
147* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98001992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis3.92868886
2MP0008877_abnormal_DNA_methylation3.69198085
3MP0004145_abnormal_muscle_electrophysio2.85974673
4MP0002102_abnormal_ear_morphology2.79643752
5MP0006054_spinal_hemorrhage2.78788830
6MP0003941_abnormal_skin_development2.68533604
7MP0006292_abnormal_olfactory_placode2.53341018
8MP0010234_abnormal_vibrissa_follicle2.51022687
9MP0002009_preneoplasia2.34455644
10MP0003283_abnormal_digestive_organ2.21415476
11MP0002638_abnormal_pupillary_reflex2.14939491
12MP0003880_abnormal_central_pattern2.14472374
13MP0005503_abnormal_tendon_morphology2.13205810
14MP0009250_abnormal_appendicular_skeleto2.02981716
15MP0006072_abnormal_retinal_apoptosis2.00271758
16MP0000566_synostosis1.96189346
17MP0005171_absent_coat_pigmentation1.96121669
18MP0004484_altered_response_of1.94616240
19MP0008438_abnormal_cutaneous_collagen1.90257915
20MP0010678_abnormal_skin_adnexa1.87896007
21MP0000537_abnormal_urethra_morphology1.86344474
22MP0005623_abnormal_meninges_morphology1.81329547
23MP0004270_analgesia1.78875008
24MP0009384_cardiac_valve_regurgitation1.78822419
25MP0002108_abnormal_muscle_morphology1.78776005
26MP0004215_abnormal_myocardial_fiber1.77440671
27MP0005379_endocrine/exocrine_gland_phen1.75212450
28MP0005551_abnormal_eye_electrophysiolog1.74923049
29MP0002163_abnormal_gland_morphology1.74212980
30MP0004272_abnormal_basement_membrane1.70140370
31MP0000778_abnormal_nervous_system1.69697356
32MP0005253_abnormal_eye_physiology1.69677061
33MP0001879_abnormal_lymphatic_vessel1.68818015
34MP0003122_maternal_imprinting1.68610352
35MP0000751_myopathy1.65065873
36MP0000749_muscle_degeneration1.64153201
37MP0003890_abnormal_embryonic-extraembry1.62207950
38MP0002160_abnormal_reproductive_system1.62071325
39MP0001188_hyperpigmentation1.61673106
40MP0000383_abnormal_hair_follicle1.55940032
41MP0001177_atelectasis1.53917928
42MP0002837_dystrophic_cardiac_calcinosis1.53662569
43MP0004084_abnormal_cardiac_muscle1.51813244
44MP0005646_abnormal_pituitary_gland1.51501853
45MP0008058_abnormal_DNA_repair1.51265339
46MP0000372_irregular_coat_pigmentation1.50340870
47MP0002938_white_spotting1.50112522
48MP0003385_abnormal_body_wall1.49666416
49MP0000427_abnormal_hair_cycle1.49532092
50MP0005409_darkened_coat_color1.48632642
51MP0003937_abnormal_limbs/digits/tail_de1.48414979
52MP0003755_abnormal_palate_morphology1.46933259
53MP0001299_abnormal_eye_distance/1.46298483
54MP0001984_abnormal_olfaction1.46017560
55MP0002234_abnormal_pharynx_morphology1.45869830
56MP0002876_abnormal_thyroid_physiology1.44466184
57MP0004036_abnormal_muscle_relaxation1.43891907
58MP0002254_reproductive_system_inflammat1.43072003
59MP0003787_abnormal_imprinting1.42942386
60MP0005369_muscle_phenotype1.41057259
61MP0005220_abnormal_exocrine_pancreas1.40250368
62MP0005620_abnormal_muscle_contractility1.39692140
63MP0000647_abnormal_sebaceous_gland1.37744227
64MP0008057_abnormal_DNA_replication1.36612502
65MP0002751_abnormal_autonomic_nervous1.34584775
66MP0003136_yellow_coat_color1.33800049
67MP0005389_reproductive_system_phenotype1.33146383
68MP0005187_abnormal_penis_morphology1.32175614
69MP0000049_abnormal_middle_ear1.31916031
70MP0000613_abnormal_salivary_gland1.31256648
71MP0002249_abnormal_larynx_morphology1.30398250
72MP0005084_abnormal_gallbladder_morpholo1.29986964
73MP0003121_genomic_imprinting1.29573049
74MP0003786_premature_aging1.28854256
75MP0003950_abnormal_plasma_membrane1.27582729
76MP0002106_abnormal_muscle_physiology1.26535011
77MP0000762_abnormal_tongue_morphology1.25346855
78MP0000569_abnormal_digit_pigmentation1.24839760
79MP0002282_abnormal_trachea_morphology1.24814900
80MP0006138_congestive_heart_failure1.24550503
81MP0004859_abnormal_synaptic_plasticity1.23741883
82MP0001486_abnormal_startle_reflex1.23617393
83MP0000516_abnormal_urinary_system1.23560933
84MP0005367_renal/urinary_system_phenotyp1.23560933
85MP0003635_abnormal_synaptic_transmissio1.23441996
86MP0004133_heterotaxia1.21957345
87MP0005275_abnormal_skin_tensile1.21868853
88MP0001958_emphysema1.20491769
89MP0005388_respiratory_system_phenotype1.19973009
90MP0002133_abnormal_respiratory_system1.19973009
91MP0008872_abnormal_physiological_respon1.18298436
92MP0000747_muscle_weakness1.17759975
93MP0008789_abnormal_olfactory_epithelium1.17286878
94MP0004147_increased_porphyrin_level1.16299024
95MP0002972_abnormal_cardiac_muscle1.15891328
96MP0001661_extended_life_span1.14720909
97MP0003646_muscle_fatigue1.14325795
98MP0004087_abnormal_muscle_fiber1.13472271
99MP0002177_abnormal_outer_ear1.13463616
100MP0009745_abnormal_behavioral_response1.12137774
101MP0003137_abnormal_impulse_conducting1.12084076
102MP0002090_abnormal_vision1.11899679
103MP0000631_abnormal_neuroendocrine_gland1.11221812
104MP0000759_abnormal_skeletal_muscle1.09528239
105MP0005508_abnormal_skeleton_morphology1.09455919
106MP0000733_abnormal_muscle_development1.08033280
107MP0004043_abnormal_pH_regulation1.07889773
108MP0003828_pulmonary_edema1.07879094
109MP0002909_abnormal_adrenal_gland1.07828649
110MP0005645_abnormal_hypothalamus_physiol1.07681334
111MP0002734_abnormal_mechanical_nocicepti1.06560241
112MP0001440_abnormal_grooming_behavior1.05952909
113MP0004085_abnormal_heartbeat1.05668527
114MP0000920_abnormal_myelination1.05035995
115MP0003938_abnormal_ear_development1.05033868
116MP0001944_abnormal_pancreas_morphology1.03612161
117MP0010368_abnormal_lymphatic_system1.01022852
118MP0008875_abnormal_xenobiotic_pharmacok1.00681273
119MP0002928_abnormal_bile_duct0.99870309
120MP0003718_maternal_effect0.99252735
121MP0003942_abnormal_urinary_system0.97921947
122MP0003935_abnormal_craniofacial_develop0.97840871
123MP0002736_abnormal_nociception_after0.97650361
124MP0002272_abnormal_nervous_system0.95611438
125MP0008775_abnormal_heart_ventricle0.95168254
126MP0009053_abnormal_anal_canal0.94862185
127MP0002896_abnormal_bone_mineralization0.94463960
128MP0001968_abnormal_touch/_nociception0.94211443
129MP0009046_muscle_twitch0.94175359
130MP0008995_early_reproductive_senescence0.93922315
131MP0002572_abnormal_emotion/affect_behav0.93890083
132MP0000428_abnormal_craniofacial_morphol0.93667031
133MP0000013_abnormal_adipose_tissue0.92746645
134MP0004742_abnormal_vestibular_system0.92670907
135MP0003252_abnormal_bile_duct0.92314956
136MP0004233_abnormal_muscle_weight0.92299067
137MP0002063_abnormal_learning/memory/cond0.92250157
138MP0002693_abnormal_pancreas_physiology0.91979767
139MP0001485_abnormal_pinna_reflex0.89456063
140MP0002114_abnormal_axial_skeleton0.88772301
141MP0010094_abnormal_chromosome_stability0.88446030
142MP0002233_abnormal_nose_morphology0.88393391
143MP0005330_cardiomyopathy0.87869032
144MP0000534_abnormal_ureter_morphology0.86254490
145MP0004134_abnormal_chest_morphology0.86030241
146MP0009697_abnormal_copulation0.85509246
147MP0009780_abnormal_chondrocyte_physiolo0.85244741
148MP0003119_abnormal_digestive_system0.84849979
149MP0002932_abnormal_joint_morphology0.84315807
150MP0003011_delayed_dark_adaptation0.84051377
151MP0001986_abnormal_taste_sensitivity0.84025998
152MP0002116_abnormal_craniofacial_bone0.83744407
153MP0005332_abnormal_amino_acid0.83120647
154MP0002295_abnormal_pulmonary_circulatio0.82442435
155MP0001919_abnormal_reproductive_system0.82403506
156MP0001929_abnormal_gametogenesis0.81045268
157MP0006036_abnormal_mitochondrial_physio0.80384763
158MP0003632_abnormal_nervous_system0.79603579
159MP0000432_abnormal_head_morphology0.77704269
160MP0002184_abnormal_innervation0.77172651
161MP0002109_abnormal_limb_morphology0.77030170
162MP0010030_abnormal_orbit_morphology0.76737413
163MP0000653_abnormal_sex_gland0.76476658
164MP0010329_abnormal_lipoprotein_level0.76303062
165MP0005167_abnormal_blood-brain_barrier0.75090524
166MP0010386_abnormal_urinary_bladder0.74847172
167MP0005410_abnormal_fertilization0.74146230
168MP0001529_abnormal_vocalization0.73855475
169MP0005386_behavior/neurological_phenoty0.73726042
170MP0004924_abnormal_behavior0.73726042
171MP0005499_abnormal_olfactory_system0.73024911
172MP0005394_taste/olfaction_phenotype0.73024911

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)3.69679990
2Muscle fiber inclusion bodies (HP:0100299)3.67606599
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.66810987
4Pancreatic cysts (HP:0001737)3.59121491
5Nemaline bodies (HP:0003798)3.57798459
6Muscle hypertrophy of the lower extremities (HP:0008968)3.48334034
7Exercise-induced myalgia (HP:0003738)3.31018134
8Calf muscle hypertrophy (HP:0008981)3.25340972
9Pancreatic fibrosis (HP:0100732)3.23624579
10Hypoplasia of the fovea (HP:0007750)3.19650448
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.19650448
12True hermaphroditism (HP:0010459)3.12632439
13Hyperinsulinemic hypoglycemia (HP:0000825)3.10891628
14Hypoglycemic coma (HP:0001325)3.07872082
15Short hallux (HP:0010109)3.07867310
16Abnormality of the nasal septum (HP:0000419)3.06130708
17Intestinal atresia (HP:0011100)3.00330258
18Abnormality of the renal cortex (HP:0011035)2.94628490
19Type 1 muscle fiber predominance (HP:0003803)2.90580701
20Renal cortical cysts (HP:0000803)2.86448184
21Abnormality of the calf musculature (HP:0001430)2.85686069
22Aplasia of the phalanges of the hand (HP:0009802)2.83036905
23Aplasia involving bones of the extremities (HP:0009825)2.83036905
24Aplasia involving bones of the upper limbs (HP:0009823)2.83036905
25Hypoglycemic seizures (HP:0002173)2.82532130
26Abnormality of the fovea (HP:0000493)2.80581619
27Methylmalonic acidemia (HP:0002912)2.79339650
28Hypoplastic ischia (HP:0003175)2.78695873
29Aplasia/Hypoplasia of the hallux (HP:0008362)2.74995128
30Ketoacidosis (HP:0001993)2.69839599
31Nephronophthisis (HP:0000090)2.69058646
32Pancreatic islet-cell hyperplasia (HP:0004510)2.68248725
33Neoplasm of the adrenal cortex (HP:0100641)2.67120923
34Molar tooth sign on MRI (HP:0002419)2.57338707
35Abnormality of midbrain morphology (HP:0002418)2.57338707
36Round ear (HP:0100830)2.56091716
37Muscle fiber splitting (HP:0003555)2.55886175
38Exercise-induced muscle cramps (HP:0003710)2.55028230
39Hyperglycemia (HP:0003074)2.53767126
40Medial flaring of the eyebrow (HP:0010747)2.49970257
41Hyporeflexia of lower limbs (HP:0002600)2.49622373
42Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.43931010
43Absent phalangeal crease (HP:0006109)2.43621034
44Abnormality of the pancreatic islet cells (HP:0006476)2.41129072
45Abnormality of endocrine pancreas physiology (HP:0012093)2.41129072
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.41045956
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40366321
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.40366321
49Abnormality of the middle phalanges of the toes (HP:0010183)2.40107013
50Abnormality of the ischium (HP:0003174)2.39862196
51Large for gestational age (HP:0001520)2.37270543
52Progressive macrocephaly (HP:0004481)2.35438248
53Abnormality of the renal medulla (HP:0100957)2.35196210
54Bell-shaped thorax (HP:0001591)2.32678415
55Increased variability in muscle fiber diameter (HP:0003557)2.28572956
56Rimmed vacuoles (HP:0003805)2.24634226
57Morphological abnormality of the middle ear (HP:0008609)2.23997930
58Abnormal pancreas size (HP:0012094)2.23459557
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22901183
60Hypoplastic left heart (HP:0004383)2.21699306
61Abnormality of skeletal muscle fiber size (HP:0012084)2.21456753
62Cutaneous finger syndactyly (HP:0010554)2.21305427
63Congenital stationary night blindness (HP:0007642)2.20537437
64Metaphyseal dysplasia (HP:0100255)2.20186121
65Absent frontal sinuses (HP:0002688)2.20140967
66Hypomagnesemia (HP:0002917)2.18969296
67Distal arthrogryposis (HP:0005684)2.18519317
68Aqueductal stenosis (HP:0002410)2.17736437
69Abnormality of the proximal phalanges of the hand (HP:0009834)2.16469632
70Syringomyelia (HP:0003396)2.16271503
71Spinal cord lesions (HP:0100561)2.16271503
72Disproportionate short-trunk short stature (HP:0003521)2.14727611
73Neoplasm of the adrenal gland (HP:0100631)2.14373900
74Thyroiditis (HP:0100646)2.13263019
75Optic nerve hypoplasia (HP:0000609)2.12592986
76Abnormality of aspartate family amino acid metabolism (HP:0010899)2.12179601
77Premature rupture of membranes (HP:0001788)2.12072620
78Attenuation of retinal blood vessels (HP:0007843)2.11552464
79Abnormality of the labia minora (HP:0012880)2.11300767
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.09413968
81Abnormal finger flexion creases (HP:0006143)2.09154402
82Cutaneous syndactyly (HP:0012725)2.08211257
83Ketosis (HP:0001946)2.07955737
84Progressive inability to walk (HP:0002505)2.07868188
85Gaze-evoked nystagmus (HP:0000640)2.06392339
86Focal motor seizures (HP:0011153)2.05994478
87Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.05914322
88Hypoplastic heart (HP:0001961)2.05424156
89Broad-based gait (HP:0002136)2.05416296
90Acute necrotizing encephalopathy (HP:0006965)2.05257555
91Synostosis involving the elbow (HP:0003938)2.05255947
92Humeroradial synostosis (HP:0003041)2.05255947
93Popliteal pterygium (HP:0009756)2.04534381
94Furrowed tongue (HP:0000221)2.02867049
95Abnormality of the phalanges of the 5th finger (HP:0004213)2.02185143
96EMG: myopathic abnormalities (HP:0003458)2.01606360
97Abnormality of vitamin B metabolism (HP:0004340)2.01559523
98Abnormality of methionine metabolism (HP:0010901)2.01556003
99Symphalangism affecting the phalanges of the hand (HP:0009773)2.01001591
100Spinal rigidity (HP:0003306)2.00762691
101Long nose (HP:0003189)2.00222258
102Hypoplasia of the iris (HP:0007676)1.99615083
103Cupped ear (HP:0000378)1.98731152
104Shoulder girdle muscle weakness (HP:0003547)1.95904969
105Limited hip movement (HP:0008800)1.95348791
106Cystic liver disease (HP:0006706)1.94828783
107Methylmalonic aciduria (HP:0012120)1.94506021
108Acute encephalopathy (HP:0006846)1.93604775
109Pendular nystagmus (HP:0012043)1.93191825
110Type II lissencephaly (HP:0007260)1.92665033
111Tubular atrophy (HP:0000092)1.91590598
112Hip contracture (HP:0003273)1.90761497
113Abnormal rod and cone electroretinograms (HP:0008323)1.90548527
114Abnormality of incisor morphology (HP:0011063)1.90536778
115Symptomatic seizures (HP:0011145)1.89616678
116Pulmonary artery stenosis (HP:0004415)1.88441694
117Aplasia/Hypoplasia of the sternum (HP:0006714)1.88236418
118Atrial fibrillation (HP:0005110)1.88030541
119Supernumerary spleens (HP:0009799)1.84742345
120Abolished electroretinogram (ERG) (HP:0000550)1.84648638
121Increased CSF lactate (HP:0002490)1.84550170
122Tongue fasciculations (HP:0001308)1.84545600
123Tarsal synostosis (HP:0008368)1.84172614
124Mesomelia (HP:0003027)1.83927147
125Bile duct proliferation (HP:0001408)1.81687942
126Abnormal biliary tract physiology (HP:0012439)1.81687942
127Infantile muscular hypotonia (HP:0008947)1.81417942
128Sclerocornea (HP:0000647)1.81246671
129Abnormal biliary tract morphology (HP:0012440)1.81175629
130Synostosis involving bones of the lower limbs (HP:0009138)1.79904350
131Synostosis involving bones of the feet (HP:0009140)1.79904350
132Lip pit (HP:0100267)1.79381555
133Exotropia (HP:0000577)1.79298322
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.79274811
135Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78410789
136Abnormality of the hip-girdle musculature (HP:0001445)1.78196710
137Abnormality of the musculature of the pelvis (HP:0001469)1.78196710
138Neck muscle weakness (HP:0000467)1.77439497
139Long clavicles (HP:0000890)1.76580079
140Male pseudohermaphroditism (HP:0000037)1.76482136
141Hepatic necrosis (HP:0002605)1.76404955
142Adrenal hypoplasia (HP:0000835)1.76344086
143Fair hair (HP:0002286)1.75653150
144Atonic seizures (HP:0010819)1.75402760
145Aplasia/hypoplasia of the uterus (HP:0008684)1.75126073
146Abnormality of the 2nd finger (HP:0004100)1.74406555
147Steppage gait (HP:0003376)1.74118058
148Sensory axonal neuropathy (HP:0003390)1.73969241
149Genital tract atresia (HP:0001827)1.73916327
150Polydipsia (HP:0001959)1.73815995
151Abnormal drinking behavior (HP:0030082)1.73815995
152Abnormality of chromosome stability (HP:0003220)1.73784604
153Volvulus (HP:0002580)1.73569710
154Breast carcinoma (HP:0003002)1.72601454
155Chronic hepatic failure (HP:0100626)1.72490964
156Anencephaly (HP:0002323)1.72310198
157Increased corneal curvature (HP:0100692)1.72242910
158Keratoconus (HP:0000563)1.72242910
159Abnormality of the pubic bones (HP:0003172)1.72183070
160Aplasia/Hypoplasia of the macula (HP:0008059)1.71947039
161Calcaneovalgus deformity (HP:0001848)1.71180246
162Meckel diverticulum (HP:0002245)1.71075226
163Mitochondrial inheritance (HP:0001427)1.70192106
164Abnormality of the columella (HP:0009929)1.69831618
165Short 1st metacarpal (HP:0010034)1.69754614
166Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.69754614
167Pelvic girdle muscle weakness (HP:0003749)1.69705586
168Difficulty running (HP:0009046)1.69417491
169Primary atrial arrhythmia (HP:0001692)1.69307997
170Small hand (HP:0200055)1.69082077
171Dandy-Walker malformation (HP:0001305)1.68997501
172Abnormality of the ileum (HP:0001549)1.68219269
173Scapular winging (HP:0003691)1.67866733
174Midline defect of the nose (HP:0004122)1.67162384
175Follicular hyperkeratosis (HP:0007502)1.66778142
176Shallow orbits (HP:0000586)1.66638233
177Abnormality of the frontal sinuses (HP:0002687)1.66199289
178Microglossia (HP:0000171)1.65974516
179Abnormality of the nasolacrimal system (HP:0000614)1.65454407
180Congenital hepatic fibrosis (HP:0002612)1.65331102
181Vascular tortuosity (HP:0004948)1.63439488
182Myelomeningocele (HP:0002475)1.63161483
183Hamartoma of the eye (HP:0010568)1.62930738
184Aplasia/Hypoplasia affecting the retina (HP:0008061)1.62785603
185Vaginal atresia (HP:0000148)1.61911141
186Distal lower limb amyotrophy (HP:0008944)1.61906071
187Sloping forehead (HP:0000340)1.61441851
188Abnormality of alanine metabolism (HP:0010916)1.61281178
189Hyperalaninemia (HP:0003348)1.61281178
190Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61281178
191Fetal akinesia sequence (HP:0001989)1.60987604
192Aplasia/Hypoplasia of the tibia (HP:0005772)1.60831663
193Renal hypoplasia (HP:0000089)1.60204763
194Congenital primary aphakia (HP:0007707)1.60175168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN2.95253942
2EIF2AK32.94923789
3STK392.93974733
4ERBB32.86677569
5ACVR1B2.81424491
6PNCK2.64107902
7MST42.50925449
8MKNK22.40003308
9WNK32.39873707
10PIK3CA2.34203877
11TRIM282.33631529
12CASK2.22246091
13MKNK12.22163413
14ZAK2.20737421
15MUSK2.14332272
16GRK12.13716280
17MAP4K22.00714989
18TNIK1.89334000
19EPHA41.85355183
20BCR1.81027103
21FGFR21.77556745
22WNK11.75413596
23TTN1.72070130
24PLK21.70565049
25OXSR11.69051994
26PLK31.60847871
27FRK1.48353818
28ADRBK21.47487621
29PHKG21.46141662
30PHKG11.46141662
31NEK61.41533948
32AKT31.40072313
33MAP2K71.39147588
34DMPK1.38931480
35MAP3K41.38726847
36DDR21.37457386
37WNK41.36145931
38TRPM71.35697194
39INSRR1.35087031
40BMPR21.34551022
41BRSK21.34489042
42EIF2AK11.34039545
43NUAK11.30849796
44PRKCE1.24653201
45TIE11.24306879
46EPHA31.24295836
47PAK31.22695266
48NTRK31.22688056
49FGR1.21209482
50CAMK1G1.20867458
51MAPK131.19007746
52EPHB21.14835692
53CDK31.07627229
54TAF11.07208692
55BCKDK1.06764895
56PINK11.02354423
57LATS10.99522164
58WEE10.99243894
59CAMK2A0.98714813
60PLK40.98533972
61MET0.98008715
62NLK0.97478392
63MYLK0.96742974
64CAMK2D0.95470955
65PKN10.95455376
66MAP3K60.94577309
67MAP2K40.90366485
68CAMK2B0.89997886
69STK240.89937915
70SGK20.87977841
71FER0.87407417
72MAPKAPK50.85165253
73PRPF4B0.84635291
74PTK2B0.83960752
75SGK4940.83190740
76SGK2230.83190740
77NTRK10.82674773
78CLK10.81875387
79PDGFRA0.81265238
80BUB10.80964886
81SGK10.79682330
82EIF2AK20.79281107
83STK38L0.77819659
84PDGFRB0.77296418
85ROCK20.76930537
86MINK10.72926919
87VRK10.71731107
88PASK0.67392891
89CAMKK20.67331466
90NTRK20.66720159
91PLK10.66495143
92PRKCG0.65160590
93BMPR1B0.64491831
94TLK10.64337003
95TSSK60.64229433
96STK30.64107595
97MARK10.63462637
98TGFBR10.63141805
99PRKG10.62498668
100PIK3CG0.62247197
101TAOK30.59219904
102CSNK1A1L0.58051341
103CSNK1G20.57765172
104CDK90.56920473
105CAMK2G0.56187574
106MAPK100.54898455
107SRPK10.54627333
108TTK0.53921351
109ROCK10.52834988
110KSR10.52672179
111NEK10.52042196
112GRK70.51829792
113YES10.51657023
114NME10.51247040
115PDK20.51195470
116CAMK1D0.50145235
117CSNK1G10.49025127
118ADRBK10.48401791
119IRAK10.48328393
120FLT30.47800338
121NEK90.47257776
122VRK20.46553945
123PRKAA20.46298605
124ATM0.45280970
125CSNK1G30.43755448
126CDK50.43244782
127FGFR10.42643611
128PRKACA0.40764038
129PRKCI0.40728572
130INSR0.39779415
131PRKCQ0.39509832
132IGF1R0.39307822
133CSNK1D0.38661724
134TGFBR20.38610198
135STK160.38140165
136DAPK20.37795721
137PRKACB0.37352171
138ERBB40.37048651
139FGFR30.36715570
140PRKD10.36650324
141SGK30.36500471
142CSNK1E0.35626288
143PRKAA10.34815385
144MAP2K10.33894910
145HIPK20.33521261
146SIK30.29817794
147CSNK1A10.28419852
148TEC0.27002382
149PRKD30.26682664
150GRK50.24623749
151ABL10.24199389

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.16092576
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.81716745
3Propanoate metabolism_Homo sapiens_hsa006402.64903363
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.42854341
5Butanoate metabolism_Homo sapiens_hsa006502.31036572
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15571362
7Nicotine addiction_Homo sapiens_hsa050332.11949909
8Dilated cardiomyopathy_Homo sapiens_hsa054142.11324229
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08253821
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.06373098
11Vitamin B6 metabolism_Homo sapiens_hsa007501.96279951
12Long-term potentiation_Homo sapiens_hsa047201.88403501
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.83511908
14Glutamatergic synapse_Homo sapiens_hsa047241.83331585
15Long-term depression_Homo sapiens_hsa047301.82137101
16Non-homologous end-joining_Homo sapiens_hsa034501.77947720
17Selenocompound metabolism_Homo sapiens_hsa004501.77915277
18ECM-receptor interaction_Homo sapiens_hsa045121.77783947
19Circadian entrainment_Homo sapiens_hsa047131.75910395
20Serotonergic synapse_Homo sapiens_hsa047261.73580560
21Proteasome_Homo sapiens_hsa030501.67102007
22RNA degradation_Homo sapiens_hsa030181.66986045
23Steroid biosynthesis_Homo sapiens_hsa001001.66837101
24Axon guidance_Homo sapiens_hsa043601.66315093
25GABAergic synapse_Homo sapiens_hsa047271.65622345
26Tryptophan metabolism_Homo sapiens_hsa003801.64634273
27Caffeine metabolism_Homo sapiens_hsa002321.61569597
28Fanconi anemia pathway_Homo sapiens_hsa034601.60397373
29Homologous recombination_Homo sapiens_hsa034401.58247623
30Nitrogen metabolism_Homo sapiens_hsa009101.56912811
31Renin secretion_Homo sapiens_hsa049241.56885075
32Morphine addiction_Homo sapiens_hsa050321.56398357
33Amphetamine addiction_Homo sapiens_hsa050311.53815122
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51718785
35Ether lipid metabolism_Homo sapiens_hsa005651.51306341
36Oxytocin signaling pathway_Homo sapiens_hsa049211.49996360
37TGF-beta signaling pathway_Homo sapiens_hsa043501.48833533
38Focal adhesion_Homo sapiens_hsa045101.48433339
39Dopaminergic synapse_Homo sapiens_hsa047281.46415070
40Calcium signaling pathway_Homo sapiens_hsa040201.44323937
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43622101
42Cardiac muscle contraction_Homo sapiens_hsa042601.42327693
43Tight junction_Homo sapiens_hsa045301.40548277
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38080872
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.37906690
46Olfactory transduction_Homo sapiens_hsa047401.36689969
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34457074
48Melanogenesis_Homo sapiens_hsa049161.33672295
49Peroxisome_Homo sapiens_hsa041461.33477664
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32396943
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.32080397
52Gastric acid secretion_Homo sapiens_hsa049711.32050811
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31960157
54Taste transduction_Homo sapiens_hsa047421.31111511
55Salivary secretion_Homo sapiens_hsa049701.30222115
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28811946
57Cholinergic synapse_Homo sapiens_hsa047251.28436433
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26739363
59Adherens junction_Homo sapiens_hsa045201.24872199
60RNA polymerase_Homo sapiens_hsa030201.24558040
61Collecting duct acid secretion_Homo sapiens_hsa049661.22116177
62Wnt signaling pathway_Homo sapiens_hsa043101.19613229
63Hippo signaling pathway_Homo sapiens_hsa043901.18192750
64Fatty acid metabolism_Homo sapiens_hsa012121.17133458
65cAMP signaling pathway_Homo sapiens_hsa040241.14343435
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.14120646
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13835398
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13456499
69Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12774350
70Fatty acid degradation_Homo sapiens_hsa000711.12115559
71Linoleic acid metabolism_Homo sapiens_hsa005911.11029228
72Gap junction_Homo sapiens_hsa045401.09574094
73Hedgehog signaling pathway_Homo sapiens_hsa043401.08775774
74Sulfur metabolism_Homo sapiens_hsa009201.07552457
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07380027
76Regulation of autophagy_Homo sapiens_hsa041401.06885429
77GnRH signaling pathway_Homo sapiens_hsa049121.04742610
78beta-Alanine metabolism_Homo sapiens_hsa004101.02750942
79Ovarian steroidogenesis_Homo sapiens_hsa049131.01975382
80Melanoma_Homo sapiens_hsa052181.01308919
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00881918
82Basal cell carcinoma_Homo sapiens_hsa052170.99202072
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98990921
84Proteoglycans in cancer_Homo sapiens_hsa052050.98442493
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98309418
86Dorso-ventral axis formation_Homo sapiens_hsa043200.97897955
87ABC transporters_Homo sapiens_hsa020100.97803339
88Choline metabolism in cancer_Homo sapiens_hsa052310.97720829
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95480639
90Prostate cancer_Homo sapiens_hsa052150.94075480
91One carbon pool by folate_Homo sapiens_hsa006700.92877022
92Ras signaling pathway_Homo sapiens_hsa040140.92832470
93RNA transport_Homo sapiens_hsa030130.92292607
94Insulin secretion_Homo sapiens_hsa049110.89135056
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.88863852
96Renal cell carcinoma_Homo sapiens_hsa052110.87957675
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86548335
98Rap1 signaling pathway_Homo sapiens_hsa040150.86505703
99Retinol metabolism_Homo sapiens_hsa008300.86051335
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84767384
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84626962
102Cocaine addiction_Homo sapiens_hsa050300.84435819
103Alzheimers disease_Homo sapiens_hsa050100.83102266
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82497651
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82111972
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80504839
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.80289203
108Pyruvate metabolism_Homo sapiens_hsa006200.80045812
109MAPK signaling pathway_Homo sapiens_hsa040100.79832826
110MicroRNAs in cancer_Homo sapiens_hsa052060.78630968
111Glioma_Homo sapiens_hsa052140.77569531
112ErbB signaling pathway_Homo sapiens_hsa040120.77402789
113Platelet activation_Homo sapiens_hsa046110.76481684
114Thyroid hormone synthesis_Homo sapiens_hsa049180.76195924
115Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74948903
116Pancreatic secretion_Homo sapiens_hsa049720.74365648
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73779679
118Chemical carcinogenesis_Homo sapiens_hsa052040.73221607
119Glucagon signaling pathway_Homo sapiens_hsa049220.72534621
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.72262903
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72205834
122Estrogen signaling pathway_Homo sapiens_hsa049150.72152167
123Circadian rhythm_Homo sapiens_hsa047100.71783339
124Purine metabolism_Homo sapiens_hsa002300.71555553
125Mineral absorption_Homo sapiens_hsa049780.69888422
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.69605804
127Phototransduction_Homo sapiens_hsa047440.64988389
128Parkinsons disease_Homo sapiens_hsa050120.64855952
129Metabolic pathways_Homo sapiens_hsa011000.63531150
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62233073
131Protein digestion and absorption_Homo sapiens_hsa049740.62056682
132Fatty acid elongation_Homo sapiens_hsa000620.61490954
133Alcoholism_Homo sapiens_hsa050340.60947878
134Oocyte meiosis_Homo sapiens_hsa041140.60698246
135Pathways in cancer_Homo sapiens_hsa052000.59517388
136Amoebiasis_Homo sapiens_hsa051460.57589260
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57493261
138Sphingolipid metabolism_Homo sapiens_hsa006000.57449675
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57247858
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56166364
141Fatty acid biosynthesis_Homo sapiens_hsa000610.55455403
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55412639
143Fat digestion and absorption_Homo sapiens_hsa049750.54992319
144FoxO signaling pathway_Homo sapiens_hsa040680.53739594
145Glutathione metabolism_Homo sapiens_hsa004800.53347419
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51869105
147Mismatch repair_Homo sapiens_hsa034300.51767186
148Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51406030
149Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51243283
150Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51223153
151Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51135312
152Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51090176
153Nucleotide excision repair_Homo sapiens_hsa034200.50478795
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50197807
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.49408076
156Basal transcription factors_Homo sapiens_hsa030220.49361847
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49045617
158Vitamin digestion and absorption_Homo sapiens_hsa049770.48240359
159Oxidative phosphorylation_Homo sapiens_hsa001900.47678328
160Glycerolipid metabolism_Homo sapiens_hsa005610.46967572
161Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45513733
162Small cell lung cancer_Homo sapiens_hsa052220.45276823
163Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44904589
164Starch and sucrose metabolism_Homo sapiens_hsa005000.44898190
165Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44860546
166p53 signaling pathway_Homo sapiens_hsa041150.44827974
167Lysine degradation_Homo sapiens_hsa003100.44521197
168Leukocyte transendothelial migration_Homo sapiens_hsa046700.44221033
169Protein export_Homo sapiens_hsa030600.43138849
170SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41684169
171N-Glycan biosynthesis_Homo sapiens_hsa005100.38731393
172Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38230001

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