STRN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.65636751
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.62839189
3synaptic vesicle maturation (GO:0016188)5.45978311
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.20586900
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.07969742
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.93456676
7vocalization behavior (GO:0071625)4.90445354
8layer formation in cerebral cortex (GO:0021819)4.70072711
9regulation of glutamate receptor signaling pathway (GO:1900449)4.64845642
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.63772475
11synaptic vesicle exocytosis (GO:0016079)4.47538640
12glutamate secretion (GO:0014047)4.45295336
13negative regulation of erythrocyte differentiation (GO:0045647)4.43272425
14regulation of synapse structural plasticity (GO:0051823)4.37595588
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.34002377
16planar cell polarity pathway involved in neural tube closure (GO:0090179)4.31125871
17dendritic spine morphogenesis (GO:0060997)4.30388609
18exploration behavior (GO:0035640)4.28621840
19regulation of neuronal synaptic plasticity (GO:0048168)4.15983896
20positive regulation of synapse maturation (GO:0090129)4.14972418
21regulation of synaptic vesicle exocytosis (GO:2000300)4.11631022
22protein localization to synapse (GO:0035418)4.11096365
23regulation of mammary gland epithelial cell proliferation (GO:0033599)4.10149926
24apoptotic process involved in morphogenesis (GO:0060561)3.99442792
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97262106
26adherens junction assembly (GO:0034333)3.95776035
27G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.93503072
28regulation of dendritic spine morphogenesis (GO:0061001)3.89081712
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.88670586
30glutamate receptor signaling pathway (GO:0007215)3.75119257
31regulation of synaptic vesicle transport (GO:1902803)3.70922277
32synaptic transmission, glutamatergic (GO:0035249)3.68159797
33focal adhesion assembly (GO:0048041)3.68120211
34cell-substrate adherens junction assembly (GO:0007045)3.68120211
35regulation of early endosome to late endosome transport (GO:2000641)3.66300446
36neuron cell-cell adhesion (GO:0007158)3.65272394
37neuron recognition (GO:0008038)3.62133582
38activation of protein kinase A activity (GO:0034199)3.60090108
39intracellular estrogen receptor signaling pathway (GO:0030520)3.58854445
40protein localization to endosome (GO:0036010)3.56603240
41long-term memory (GO:0007616)3.55304369
42neurotransmitter secretion (GO:0007269)3.51158166
43neuromuscular process controlling balance (GO:0050885)3.50824775
44heterochromatin organization (GO:0070828)3.46541397
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46461682
46neuronal action potential propagation (GO:0019227)3.45613918
47regulation of NFAT protein import into nucleus (GO:0051532)3.42813223
48semaphorin-plexin signaling pathway (GO:0071526)3.42658113
49activation of Rac GTPase activity (GO:0032863)3.41819811
50cytoskeletal anchoring at plasma membrane (GO:0007016)3.40989868
51dendrite morphogenesis (GO:0048813)3.39755289
52dendritic spine organization (GO:0097061)3.39242585
53COPI coating of Golgi vesicle (GO:0048205)3.39160797
54Golgi transport vesicle coating (GO:0048200)3.39160797
553-UTR-mediated mRNA stabilization (GO:0070935)3.38088871
56regulation of synaptic plasticity (GO:0048167)3.37791358
57axonal fasciculation (GO:0007413)3.36610841
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.36110224
59regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35011569
60cell-cell junction maintenance (GO:0045217)3.33523424
61positive regulation of membrane potential (GO:0045838)3.32735979
62negative regulation of cell size (GO:0045792)3.31968252
63sodium ion export (GO:0071436)3.30973292
64neuron-neuron synaptic transmission (GO:0007270)3.29981723
65maternal placenta development (GO:0001893)3.28960315
66cell communication by electrical coupling (GO:0010644)3.27877003
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.27637011
68regulation of postsynaptic membrane potential (GO:0060078)3.26022200
69neuronal ion channel clustering (GO:0045161)3.25163494
70nucleosome disassembly (GO:0006337)3.25109408
71protein-DNA complex disassembly (GO:0032986)3.25109408
72regulation of dendritic spine development (GO:0060998)3.23912954
73regulation of chromatin binding (GO:0035561)3.23790947
74nerve growth factor signaling pathway (GO:0038180)3.23425754
75cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.22313439
76transmission of nerve impulse (GO:0019226)3.21470606
77cell migration in hindbrain (GO:0021535)3.20300071
78protein retention in ER lumen (GO:0006621)3.19691014
79positive regulation of Cdc42 GTPase activity (GO:0043089)3.16106927
80positive regulation of dendritic spine development (GO:0060999)3.15406091
81neurotransmitter-gated ion channel clustering (GO:0072578)3.14690998
82cerebellar Purkinje cell differentiation (GO:0021702)3.14134950
83establishment of nucleus localization (GO:0040023)3.14093100
84proline transport (GO:0015824)3.12378383
85mannose metabolic process (GO:0006013)3.11794986
86mRNA stabilization (GO:0048255)3.10832797
87RNA stabilization (GO:0043489)3.10832797
88stress fiber assembly (GO:0043149)3.10002166
89cell-substrate junction assembly (GO:0007044)3.08296730
90maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.08192795
91cellular potassium ion homeostasis (GO:0030007)3.06711062
92regulation of glucose import in response to insulin stimulus (GO:2001273)3.04777592
93basement membrane organization (GO:0071711)3.03461434
94synaptic vesicle endocytosis (GO:0048488)3.01619728
95epithelial cell-cell adhesion (GO:0090136)3.01098708
96regulation of synapse maturation (GO:0090128)2.99937876
97regulation of ARF GTPase activity (GO:0032312)2.99350664
98positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.99034112
99DNA unwinding involved in DNA replication (GO:0006268)2.98248768
100regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97941110
101proline biosynthetic process (GO:0006561)2.96457284
102long-term synaptic potentiation (GO:0060291)2.94513297
103regulation of ARF protein signal transduction (GO:0032012)2.92447100
104modulation by virus of host process (GO:0019054)2.91247321
105convergent extension (GO:0060026)2.89793342
106embryonic process involved in female pregnancy (GO:0060136)2.87755857
107modulation by symbiont of host cellular process (GO:0044068)2.87703959
108behavioral defense response (GO:0002209)2.87679698
109behavioral fear response (GO:0001662)2.87679698
110retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86852910
111peptidyl-arginine omega-N-methylation (GO:0035247)2.86346562
112positive regulation of dendrite development (GO:1900006)2.85508565
113membrane depolarization (GO:0051899)2.85352703
114regulation of synaptic transmission, glutamatergic (GO:0051966)2.85314546
115membrane depolarization during action potential (GO:0086010)2.85175060
116auditory behavior (GO:0031223)2.85032576
117positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.84569764
118prepulse inhibition (GO:0060134)2.81838496
119positive regulation of dendrite morphogenesis (GO:0050775)2.81831771
120regulation of Rap GTPase activity (GO:0032317)2.81350834
121clathrin coat assembly (GO:0048268)2.79771621
122pentose-phosphate shunt (GO:0006098)2.79054025
123gamma-aminobutyric acid transport (GO:0015812)2.77671307
124positive regulation of neurotransmitter secretion (GO:0001956)2.77371906
125positive regulation of fibroblast migration (GO:0010763)2.77145139
126spliceosomal tri-snRNP complex assembly (GO:0000244)2.76741443
127regulation of neurotransmitter secretion (GO:0046928)2.75467909
128central nervous system projection neuron axonogenesis (GO:0021952)2.75305787
129postsynaptic membrane organization (GO:0001941)2.73188325
130cerebellar Purkinje cell layer development (GO:0021680)2.72903008
131regulation of vesicle fusion (GO:0031338)2.71393813
132neuromuscular process (GO:0050905)2.69968472
133glycine transport (GO:0015816)2.69518991
134cellular response to epidermal growth factor stimulus (GO:0071364)2.69466651
135neurotransmitter transport (GO:0006836)2.68949023
136negative regulation of organelle assembly (GO:1902116)2.68373199
137response to laminar fluid shear stress (GO:0034616)2.67909429
138vesicle transport along microtubule (GO:0047496)2.67862392
139fear response (GO:0042596)2.67563860
140positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67430814
141cellular response to virus (GO:0098586)2.67308933
142mating behavior (GO:0007617)2.66399720
143negative regulation of microtubule polymerization (GO:0031115)2.66122090
144signal complex assembly (GO:0007172)2.64895925
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.64177803
146epithelial cell differentiation involved in prostate gland development (GO:0060742)2.63922578
147innervation (GO:0060384)2.63833541
148synapse organization (GO:0050808)2.63785581
149chemosensory behavior (GO:0007635)2.63254073
150gamma-aminobutyric acid signaling pathway (GO:0007214)2.62568299
151apoptotic process involved in development (GO:1902742)2.62266892
152regulation of dendrite morphogenesis (GO:0048814)2.62064398
153negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.61261506
154negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.61000522
155regulation of nucleobase-containing compound transport (GO:0032239)2.59922395
156positive regulation of receptor recycling (GO:0001921)2.59028252
157glucose 6-phosphate metabolic process (GO:0051156)2.58867690
158negative regulation of fatty acid transport (GO:2000192)2.58458892
159regulation of RNA export from nucleus (GO:0046831)2.56624695
160barbed-end actin filament capping (GO:0051016)2.55649819
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55316848
162positive regulation of blood vessel endothelial cell migration (GO:0043536)2.53778246
163protein targeting to plasma membrane (GO:0072661)2.53133971
164glucose catabolic process (GO:0006007)2.53059105
165positive regulation of histone deacetylation (GO:0031065)2.51825038
166negative regulation of histone methylation (GO:0031061)2.51354213
167mitotic chromosome condensation (GO:0007076)2.51047376
168atrioventricular valve morphogenesis (GO:0003181)2.49803562
169modulation by virus of host morphology or physiology (GO:0019048)2.49700030
170Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.48968027
171negative regulation of myotube differentiation (GO:0010832)2.48505856
172activation of MAPKKK activity (GO:0000185)2.47006634
173positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.43830256
174negative regulation of viral release from host cell (GO:1902187)2.42813841
175glucocorticoid receptor signaling pathway (GO:0042921)2.41567588
176regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.40990175
177neural tube development (GO:0021915)2.40836031
178cell junction maintenance (GO:0034331)2.40551359
179establishment of apical/basal cell polarity (GO:0035089)2.38565388
180protein complex localization (GO:0031503)2.36378866
181regulation of histone H3-K27 methylation (GO:0061085)2.35694313
182cellular protein complex localization (GO:0034629)2.34231731
183histone arginine methylation (GO:0034969)2.34123496
184activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.32836113
185embryonic eye morphogenesis (GO:0048048)2.32762890
186regulation of establishment of planar polarity (GO:0090175)2.31045586
187negative regulation of striated muscle cell differentiation (GO:0051154)2.30582265
188peptidyl-arginine N-methylation (GO:0035246)2.29505084
189peptidyl-arginine methylation (GO:0018216)2.29505084
190vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.28958639
191response to muramyl dipeptide (GO:0032495)2.28325992
192regulation of extracellular matrix disassembly (GO:0010715)2.28225410
193response to epidermal growth factor (GO:0070849)2.26834647
194dosage compensation (GO:0007549)2.26066740
195NADPH regeneration (GO:0006740)2.25285696
196positive regulation of nuclease activity (GO:0032075)2.25252776
197actin filament bundle organization (GO:0061572)2.24948088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88311391
2MYC_22102868_ChIP-Seq_BL_Human2.99433051
3* RARB_27405468_Chip-Seq_BRAIN_Mouse2.94277560
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.87681288
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85113980
6VDR_21846776_ChIP-Seq_THP-1_Human2.79798628
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.79431788
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75656510
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.69545733
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.69545733
11DROSHA_22980978_ChIP-Seq_HELA_Human2.68723164
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.65190471
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.63690534
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54474038
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.53795203
16REST_21632747_ChIP-Seq_MESCs_Mouse2.44128123
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43692786
18MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.42385110
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40534790
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37275330
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36055126
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.35635044
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.35549802
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.32374914
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28398095
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.28256263
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.27223798
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26876783
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.26642492
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.26054543
31GBX2_23144817_ChIP-Seq_PC3_Human2.21897326
32RACK7_27058665_Chip-Seq_MCF-7_Human2.21004613
33EGR1_19374776_ChIP-ChIP_THP-1_Human2.09779667
34IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07939784
35REST_18959480_ChIP-ChIP_MESCs_Mouse2.04654125
36EED_16625203_ChIP-ChIP_MESCs_Mouse2.01198771
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97361788
38E2F7_22180533_ChIP-Seq_HELA_Human1.93698855
39KDM2B_26808549_Chip-Seq_K562_Human1.89023616
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86539855
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.80707874
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.80535997
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79266438
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76896059
45EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76451791
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.66583135
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63343959
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63098269
49ZNF263_19887448_ChIP-Seq_K562_Human1.62653144
50ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62249288
51* RING1B_27294783_Chip-Seq_ESCs_Mouse1.61553983
52* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.60865061
53P68_20966046_ChIP-Seq_HELA_Human1.60026196
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.55000599
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.54901702
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53186243
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52860543
58KDM2B_26808549_Chip-Seq_DND41_Human1.49224858
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.48228244
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.47309217
61VDR_24763502_ChIP-Seq_THP-1_Human1.47170286
62RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46282806
63RING1B_27294783_Chip-Seq_NPCs_Mouse1.45838231
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44295952
65* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42001790
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41233956
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.40612754
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.40579194
69CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40404143
70PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39463112
71WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39373722
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38734502
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38616463
74MAF_26560356_Chip-Seq_TH1_Human1.38533488
75FOXM1_23109430_ChIP-Seq_U2OS_Human1.38516234
76LXR_22292898_ChIP-Seq_THP-1_Human1.37581947
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.37196820
78NCOR1_26117541_ChIP-Seq_K562_Human1.36563167
79CLOCK_20551151_ChIP-Seq_293T_Human1.34965637
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30665298
81UTX_26944678_Chip-Seq_JUKART_Human1.29051002
82ZNF274_21170338_ChIP-Seq_K562_Hela1.28059471
83CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27912162
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27741975
85CTCF_27219007_Chip-Seq_Bcells_Human1.27722138
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27249249
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24999702
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24923628
89RUNX1_22412390_ChIP-Seq_EML_Mouse1.24162443
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23629959
91* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23368197
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.23365231
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23173114
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.23057087
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21341072
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.20618125
97MAF_26560356_Chip-Seq_TH2_Human1.20592034
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20355979
99ATF3_27146783_Chip-Seq_COLON_Human1.19972685
100TP53_22127205_ChIP-Seq_IMR90_Human1.17787177
101AR_21572438_ChIP-Seq_LNCaP_Human1.17539636
102AR_19668381_ChIP-Seq_PC3_Human1.16776777
103BRD4_27068464_Chip-Seq_AML-cells_Mouse1.16247396
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15841001
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15681283
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.14816634
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14693517
108E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14371845
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10914773
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.10883239
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.09850209
112TET1_21490601_ChIP-Seq_MESCs_Mouse1.09460576
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.08818274
114SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07695982
115CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06016279
116SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04634841
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03977240
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.03947087
119SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03838112
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03139214
121TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02464683
122SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02208191
123GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.01768402
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01385146
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99896900
126* GATA1_19941827_ChIP-Seq_MEL_Mouse0.99842436
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99720763
128SMAD3_21741376_ChIP-Seq_ESCs_Human0.99564884
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99562778
130SMC4_20622854_ChIP-Seq_HELA_Human0.99534857
131* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.99480682
132BCOR_27268052_Chip-Seq_Bcells_Human0.98957345
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.98580405
134* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98126103
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97556191
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97346030
137THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97221316
138CREB1_26743006_Chip-Seq_LNCaP_Human0.96354094
139AHR_22903824_ChIP-Seq_MCF-7_Human0.95687363
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94364770
141* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93656367
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93398064
143TCF7_22412390_ChIP-Seq_EML_Mouse0.93030523
144UBF1/2_26484160_Chip-Seq_HMECs_Human0.92858015
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92853832
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.92397606
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92362970
148SMAD4_21799915_ChIP-Seq_A2780_Human0.92308032
149PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91131192
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90476615
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.90255996
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89946676
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88543703
154ISL1_27105846_Chip-Seq_CPCs_Mouse0.86741025
155CBX2_27304074_Chip-Seq_ESCs_Mouse0.86644134
156TP53_20018659_ChIP-ChIP_R1E_Mouse0.86183133
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.84268502
158SMAD4_21741376_ChIP-Seq_HESCs_Human0.84145821
159* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83596033
160PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82977533
161KLF4_19829295_ChIP-Seq_ESCs_Human0.82927709
162OCT4_19829295_ChIP-Seq_ESCs_Human0.82468511
163MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.81184985
164MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80981226
165TP53_16413492_ChIP-PET_HCT116_Human0.80732413
166ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80481156
167P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78067733
168PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76722771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.22178203
2MP0003705_abnormal_hypodermis_morpholog5.31690274
3MP0003880_abnormal_central_pattern4.14768284
4MP0003635_abnormal_synaptic_transmissio4.04481367
5MP0004270_analgesia3.38488689
6MP0002063_abnormal_learning/memory/cond3.26698883
7MP0009745_abnormal_behavioral_response2.99285516
8MP0002822_catalepsy2.91897616
9MP0001849_ear_inflammation2.74388117
10MP0002064_seizures2.72276443
11MP0009278_abnormal_bone_marrow2.64597390
12MP0005451_abnormal_body_composition2.63424471
13MP0003566_abnormal_cell_adhesion2.57040015
14MP0002877_abnormal_melanocyte_morpholog2.47304626
15MP0004185_abnormal_adipocyte_glucose2.41939051
16MP0002572_abnormal_emotion/affect_behav2.41794478
17MP0005423_abnormal_somatic_nervous2.25215820
18MP0001486_abnormal_startle_reflex2.24010141
19MP0009046_muscle_twitch2.17366421
20MP0005058_abnormal_lysosome_morphology2.16164981
21MP0001968_abnormal_touch/_nociception2.15160273
22MP0002272_abnormal_nervous_system2.14574828
23MP0000678_abnormal_parathyroid_gland2.08635310
24MP0009780_abnormal_chondrocyte_physiolo2.08415434
25MP0004858_abnormal_nervous_system2.04597780
26MP0002734_abnormal_mechanical_nocicepti2.01529855
27MP0000778_abnormal_nervous_system1.97887359
28MP0005409_darkened_coat_color1.97792378
29MP0004885_abnormal_endolymph1.95843218
30MP0008260_abnormal_autophagy1.95395904
31MP0003453_abnormal_keratinocyte_physiol1.93297614
32MP0002249_abnormal_larynx_morphology1.92813080
33MP0003787_abnormal_imprinting1.90678260
34MP0004811_abnormal_neuron_physiology1.87528447
35MP0001440_abnormal_grooming_behavior1.85571375
36MP0002909_abnormal_adrenal_gland1.82381813
37MP0003329_amyloid_beta_deposits1.78555269
38MP0000955_abnormal_spinal_cord1.78055002
39MP0008961_abnormal_basal_metabolism1.77761450
40MP0001501_abnormal_sleep_pattern1.77643999
41MP0003283_abnormal_digestive_organ1.75687733
42MP0002184_abnormal_innervation1.71496576
43MP0008569_lethality_at_weaning1.70883396
44MP0002796_impaired_skin_barrier1.66113526
45MP0003091_abnormal_cell_migration1.63162004
46MP0008438_abnormal_cutaneous_collagen1.62776761
47MP0002735_abnormal_chemical_nociception1.60548744
48MP0009672_abnormal_birth_weight1.60522134
49MP0005666_abnormal_adipose_tissue1.60472137
50MP0002733_abnormal_thermal_nociception1.59927695
51MP0003879_abnormal_hair_cell1.55643916
52MP0000751_myopathy1.54926062
53MP0010030_abnormal_orbit_morphology1.54839774
54MP0001970_abnormal_pain_threshold1.53047134
55MP0002557_abnormal_social/conspecific_i1.52043716
56MP0002736_abnormal_nociception_after1.51926381
57MP0001730_embryonic_growth_arrest1.51595785
58MP0002067_abnormal_sensory_capabilities1.48881535
59MP0004272_abnormal_basement_membrane1.48871684
60MP0000858_altered_metastatic_potential1.48713036
61MP0003300_gastrointestinal_ulcer1.47812785
62MP0010234_abnormal_vibrissa_follicle1.45708567
63MP0005623_abnormal_meninges_morphology1.45368366
64MP0005501_abnormal_skin_physiology1.43795951
65MP0005257_abnormal_intraocular_pressure1.43381628
66MP0003436_decreased_susceptibility_to1.41634685
67MP0005375_adipose_tissue_phenotype1.40686377
68MP0002882_abnormal_neuron_morphology1.39789102
69MP0003122_maternal_imprinting1.39730022
70MP0009053_abnormal_anal_canal1.37166819
71MP0004947_skin_inflammation1.36772461
72MP0003172_abnormal_lysosome_physiology1.35040265
73MP0003111_abnormal_nucleus_morphology1.32040588
74MP0002066_abnormal_motor_capabilities/c1.30596213
75MP0004924_abnormal_behavior1.29690292
76MP0005386_behavior/neurological_phenoty1.29690292
77MP0002234_abnormal_pharynx_morphology1.29476592
78MP0002152_abnormal_brain_morphology1.28185543
79MP0000003_abnormal_adipose_tissue1.27960783
80MP0000733_abnormal_muscle_development1.26768543
81MP0005167_abnormal_blood-brain_barrier1.24389658
82MP0009840_abnormal_foam_cell1.19247480
83MP0003633_abnormal_nervous_system1.17152508
84MP0004808_abnormal_hematopoietic_stem1.16311904
85MP0010352_gastrointestinal_tract_polyps1.13676396
86MP0005621_abnormal_cell_physiology1.09906598
87MP0004264_abnormal_extraembryonic_tissu1.09547655
88MP0002060_abnormal_skin_morphology1.08287806
89MP0004085_abnormal_heartbeat1.07189486
90MP0002254_reproductive_system_inflammat1.06971292
91MP0003115_abnormal_respiratory_system1.06940985
92MP0010630_abnormal_cardiac_muscle1.06854837
93MP0003631_nervous_system_phenotype1.06433919
94MP0000350_abnormal_cell_proliferation1.05566415
95MP0005464_abnormal_platelet_physiology1.04463935
96MP0004145_abnormal_muscle_electrophysio1.04350653
97MP0001915_intracranial_hemorrhage1.02340606
98MP0000569_abnormal_digit_pigmentation1.02031220
99MP0000566_synostosis1.01919233
100MP0002080_prenatal_lethality1.01597156
101MP0003942_abnormal_urinary_system1.00762292
102MP0002086_abnormal_extraembryonic_tissu0.99410695
103MP0003191_abnormal_cellular_cholesterol0.99333202
104MP0003279_aneurysm0.99006818
105MP0000490_abnormal_crypts_of0.98180643
106MP0000767_abnormal_smooth_muscle0.97410173
107MP0001502_abnormal_circadian_rhythm0.97384420
108MP0005380_embryogenesis_phenotype0.97219998
109MP0001672_abnormal_embryogenesis/_devel0.97219998
110MP0002396_abnormal_hematopoietic_system0.96983324
111MP0003861_abnormal_nervous_system0.95372903
112MP0005410_abnormal_fertilization0.94734241
113MP0003984_embryonic_growth_retardation0.94422298
114MP0005023_abnormal_wound_healing0.94081374
115MP0002085_abnormal_embryonic_tissue0.94075742
116MP0004742_abnormal_vestibular_system0.92816149
117MP0004510_myositis0.92719522
118MP0003828_pulmonary_edema0.91597779
119MP0003632_abnormal_nervous_system0.91447346
120MP0003634_abnormal_glial_cell0.90437039
121MP0003119_abnormal_digestive_system0.89311911
122MP0003137_abnormal_impulse_conducting0.89047997
123MP0009333_abnormal_splenocyte_physiolog0.88728937
124MP0009931_abnormal_skin_appearance0.88484585
125MP0001529_abnormal_vocalization0.88298907
126MP0004215_abnormal_myocardial_fiber0.87742787
127MP0001485_abnormal_pinna_reflex0.86354791
128MP0002925_abnormal_cardiovascular_devel0.86103259
129MP0002088_abnormal_embryonic_growth/wei0.86017541
130MP0002653_abnormal_ependyma_morphology0.85992930
131MP0001545_abnormal_hematopoietic_system0.84813551
132MP0005397_hematopoietic_system_phenotyp0.84813551
133MP0000920_abnormal_myelination0.82207832
134MP0003075_altered_response_to0.81799785
135MP0001984_abnormal_olfaction0.81505761
136MP0002069_abnormal_eating/drinking_beha0.81216514
137MP0001958_emphysema0.80652805
138MP0001346_abnormal_lacrimal_gland0.80456708
139MP0000467_abnormal_esophagus_morphology0.80200040
140MP0008874_decreased_physiological_sensi0.79624682
141MP0000534_abnormal_ureter_morphology0.78949368
142MP0003385_abnormal_body_wall0.78869975
143MP0002998_abnormal_bone_remodeling0.78795895
144MP0002837_dystrophic_cardiac_calcinosis0.77033706
145MP0001216_abnormal_epidermal_layer0.76955885
146MP0000428_abnormal_craniofacial_morphol0.76122252
147MP0005670_abnormal_white_adipose0.76048657
148MP0005187_abnormal_penis_morphology0.75880261
149MP0000537_abnormal_urethra_morphology0.75712501
150MP0004957_abnormal_blastocyst_morpholog0.75342263
151MP0004233_abnormal_muscle_weight0.75196034
152MP0000703_abnormal_thymus_morphology0.75110422
153MP0003693_abnormal_embryo_hatching0.74761432
154MP0002229_neurodegeneration0.74601247
155MP0000477_abnormal_intestine_morphology0.74320035
156MP0000759_abnormal_skeletal_muscle0.74079304
157MP0004197_abnormal_fetal_growth/weight/0.74001727
158MP0002697_abnormal_eye_size0.73745694
159MP0005646_abnormal_pituitary_gland0.73616184
160MP0003121_genomic_imprinting0.73502492
161MP0004381_abnormal_hair_follicle0.73435539
162MP0002089_abnormal_postnatal_growth/wei0.73091801
163MP0002092_abnormal_eye_morphology0.72693018
164MP0002932_abnormal_joint_morphology0.70948633
165MP0004130_abnormal_muscle_cell0.70490641
166MP0000631_abnormal_neuroendocrine_gland0.70479480
167MP0008877_abnormal_DNA_methylation0.66750546
168MP0003303_peritoneal_inflammation0.66559393
169MP0000013_abnormal_adipose_tissue0.66317114
170MP0005076_abnormal_cell_differentiation0.65295695
171MP0002752_abnormal_somatic_nervous0.65095764
172MP0000747_muscle_weakness0.64183760
173MP0005499_abnormal_olfactory_system0.63066583
174MP0005394_taste/olfaction_phenotype0.63066583
175MP0010769_abnormal_survival0.62854022
176MP0001905_abnormal_dopamine_level0.62749595
177MP0000604_amyloidosis0.62527950
178MP0001177_atelectasis0.62394844
179MP0001943_abnormal_respiration0.62182034
180MP0001348_abnormal_lacrimal_gland0.62135105
181MP0001963_abnormal_hearing_physiology0.61506078
182MP0008770_decreased_survivor_rate0.61417553
183MP0003123_paternal_imprinting0.60114001

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.78979727
2Focal motor seizures (HP:0011153)5.32536074
3Focal seizures (HP:0007359)4.59070434
4Visual hallucinations (HP:0002367)4.42912524
5Abnormality of the lower motor neuron (HP:0002366)4.00549850
6Ankle clonus (HP:0011448)3.73828961
7Supranuclear gaze palsy (HP:0000605)3.55287551
8Epileptic encephalopathy (HP:0200134)3.46231403
9Atonic seizures (HP:0010819)3.18635958
10Impaired vibration sensation in the lower limbs (HP:0002166)3.11655908
11Broad face (HP:0000283)3.08667582
12Action tremor (HP:0002345)3.02039905
13Insomnia (HP:0100785)2.99831083
14Obstructive sleep apnea (HP:0002870)2.96384385
15Amblyopia (HP:0000646)2.95917439
16Protrusio acetabuli (HP:0003179)2.94578895
17Ulnar bowing (HP:0003031)2.91077609
18Generalized tonic-clonic seizures (HP:0002069)2.77770660
19Absence seizures (HP:0002121)2.77327138
20Postural instability (HP:0002172)2.75988839
21Pointed chin (HP:0000307)2.74872344
22Annular pancreas (HP:0001734)2.74504228
23Poor eye contact (HP:0000817)2.74231297
24Depression (HP:0000716)2.74023641
25Distal lower limb amyotrophy (HP:0008944)2.73315835
26Cerebral inclusion bodies (HP:0100314)2.72552028
27Febrile seizures (HP:0002373)2.72264539
28Cerebral aneurysm (HP:0004944)2.70271064
29Dysmetria (HP:0001310)2.69444447
30Premature rupture of membranes (HP:0001788)2.67504200
31Progressive cerebellar ataxia (HP:0002073)2.66739921
32Shallow orbits (HP:0000586)2.66539095
33Disproportionate tall stature (HP:0001519)2.65851277
34Long palpebral fissure (HP:0000637)2.65446581
35Abnormal social behavior (HP:0012433)2.60711004
36Impaired social interactions (HP:0000735)2.60711004
37Dialeptic seizures (HP:0011146)2.57876365
38Dysdiadochokinesis (HP:0002075)2.56443294
39Hyperacusis (HP:0010780)2.56216199
40Urinary urgency (HP:0000012)2.50619219
41Urinary bladder sphincter dysfunction (HP:0002839)2.50223788
42Spastic gait (HP:0002064)2.49722863
43Hemiparesis (HP:0001269)2.47617467
44Lower limb amyotrophy (HP:0007210)2.42972374
45Bundle branch block (HP:0011710)2.42373141
46Progressive inability to walk (HP:0002505)2.41297297
47Stereotypic behavior (HP:0000733)2.37934988
48Broad-based gait (HP:0002136)2.35584312
49Abnormality of the distal phalanx of the thumb (HP:0009617)2.35403641
50Dysmetric saccades (HP:0000641)2.35265910
51Gaze-evoked nystagmus (HP:0000640)2.31845525
52Neoplasm of the heart (HP:0100544)2.31403879
53Papilledema (HP:0001085)2.30188488
54Increased connective tissue (HP:0009025)2.28045578
55Buphthalmos (HP:0000557)2.27814761
56Hemiplegia (HP:0002301)2.26530138
57Turricephaly (HP:0000262)2.25379537
58Termporal pattern (HP:0011008)2.23471614
59Insidious onset (HP:0003587)2.23471614
60Truncal ataxia (HP:0002078)2.22786901
61Impaired smooth pursuit (HP:0007772)2.22748811
62Amyotrophic lateral sclerosis (HP:0007354)2.22309382
63Genu recurvatum (HP:0002816)2.20714095
64Thin bony cortex (HP:0002753)2.18926828
65Ventricular fibrillation (HP:0001663)2.18345169
66Rapidly progressive (HP:0003678)2.18323434
67Abnormality of the Achilles tendon (HP:0005109)2.15235124
68Neurofibrillary tangles (HP:0002185)2.14137732
69Intention tremor (HP:0002080)2.12610600
70Centrally nucleated skeletal muscle fibers (HP:0003687)2.12078947
71Asymmetry of the thorax (HP:0001555)2.10627834
72Drooling (HP:0002307)2.09261247
73Excessive salivation (HP:0003781)2.09261247
74Flat acetabular roof (HP:0003180)2.08351073
75Lower limb muscle weakness (HP:0007340)2.07736840
76Mitral regurgitation (HP:0001653)2.06904590
77Abnormality of the fingertips (HP:0001211)2.06904430
78Broad distal phalanx of finger (HP:0009836)2.06695894
79Fragile skin (HP:0001030)2.04580633
80Abnormality of ocular smooth pursuit (HP:0000617)2.04265869
81Megalencephaly (HP:0001355)2.03356854
82Ankyloglossia (HP:0010296)2.03323437
83Anxiety (HP:0000739)2.03291529
84Metaphyseal cupping (HP:0003021)2.03045156
85Torticollis (HP:0000473)2.02777021
86Mutism (HP:0002300)2.02452794
87Resting tremor (HP:0002322)2.02023791
88Apathy (HP:0000741)2.01708210
89Elfin facies (HP:0004428)2.00559476
90Difficulty climbing stairs (HP:0003551)2.00540778
91Biconcave vertebral bodies (HP:0004586)1.98928026
92Vertebral compression fractures (HP:0002953)1.98440259
93Truncus arteriosus (HP:0001660)1.97967715
94Patellar dislocation (HP:0002999)1.97662299
95Bradykinesia (HP:0002067)1.96531068
96Overriding aorta (HP:0002623)1.96342201
97Genetic anticipation (HP:0003743)1.94609608
98Stridor (HP:0010307)1.94479120
99Sudden death (HP:0001699)1.94140096
100Abnormality of the thoracic spine (HP:0100711)1.93882691
101Increased variability in muscle fiber diameter (HP:0003557)1.92820107
102Hemorrhage of the eye (HP:0011885)1.92568772
103Macroorchidism (HP:0000053)1.92470682
104Abnormal eating behavior (HP:0100738)1.91515932
105Hyperventilation (HP:0002883)1.90711198
106Arnold-Chiari malformation (HP:0002308)1.89974095
107Achilles tendon contracture (HP:0001771)1.89283912
108Blue sclerae (HP:0000592)1.87936607
109Cervical subluxation (HP:0003308)1.87857129
110Thin ribs (HP:0000883)1.87286622
111Absent speech (HP:0001344)1.86520211
112Clonus (HP:0002169)1.85536960
113Bronchomalacia (HP:0002780)1.85103956
114Bowel incontinence (HP:0002607)1.83526809
115Obsessive-compulsive behavior (HP:0000722)1.82672211
116Deep palmar crease (HP:0006191)1.82607300
117Abnormality of the phalanges of the hallux (HP:0010057)1.82528995
118Distal lower limb muscle weakness (HP:0009053)1.80855656
119Cellulitis (HP:0100658)1.80757895
120Upper limb amyotrophy (HP:0009129)1.80154080
121Distal upper limb amyotrophy (HP:0007149)1.80154080
122Hypoventilation (HP:0002791)1.80107929
123Epileptiform EEG discharges (HP:0011182)1.79610777
124Impaired vibratory sensation (HP:0002495)1.79344020
125Generalized hypotonia (HP:0001290)1.79258582
126Focal dystonia (HP:0004373)1.79215177
127Hypoplasia of the brainstem (HP:0002365)1.78741406
128Aplasia/Hypoplasia of the brainstem (HP:0007362)1.78741406
129Abnormality of the corticospinal tract (HP:0002492)1.78158843
130Abnormality of binocular vision (HP:0011514)1.77085025
131Diplopia (HP:0000651)1.77085025
132Intellectual disability, profound (HP:0002187)1.76956786
133Neuronal loss in central nervous system (HP:0002529)1.76661174
134Difficulty running (HP:0009046)1.76402346
135Selective tooth agenesis (HP:0001592)1.76006988
136Spinal rigidity (HP:0003306)1.75669658
137Hammertoe (HP:0001765)1.75108874
138EEG with generalized epileptiform discharges (HP:0011198)1.74137226
139Mitral valve prolapse (HP:0001634)1.74044805
140Polygenic inheritance (HP:0010982)1.73492152
141Segmental peripheral demyelination/remyelination (HP:0003481)1.72630185
142Abnormality of skeletal muscle fiber size (HP:0012084)1.72539859
143Abnormal large intestine physiology (HP:0012700)1.72189278
144Bladder diverticulum (HP:0000015)1.71677200
145Abnormality of the distal phalanges of the toes (HP:0010182)1.71422275
146Renal duplication (HP:0000075)1.71223973
147Diminished motivation (HP:0000745)1.70320865
148Hyperparathyroidism (HP:0000843)1.70080405
149Abnormality of the periventricular white matter (HP:0002518)1.69095899
150Hand muscle atrophy (HP:0009130)1.68751451
151Hypsarrhythmia (HP:0002521)1.68675247
152Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68397487
153Renovascular hypertension (HP:0100817)1.67288817
154Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67085764
155Dislocated radial head (HP:0003083)1.67019999
156Germ cell neoplasia (HP:0100728)1.66066392
157Long eyelashes (HP:0000527)1.64623221
158Aneurysm (HP:0002617)1.63780265
159Broad metatarsal (HP:0001783)1.63752994
160Spinal cord lesions (HP:0100561)1.63091191
161Syringomyelia (HP:0003396)1.63091191
162Urethral obstruction (HP:0000796)1.62965600
163Abnormality of the calcaneus (HP:0008364)1.62557779
164Abnormality of oral frenula (HP:0000190)1.62525397
165Bowed forearm bones (HP:0003956)1.62508594
166Bowing of the arm (HP:0006488)1.62508594
167Myopathic facies (HP:0002058)1.61059797
168Hypercortisolism (HP:0001578)1.60832186
169Atrophic scars (HP:0001075)1.60536078
170Abnormal vertebral ossification (HP:0100569)1.60280524
171Precocious puberty (HP:0000826)1.59483323
172Premature skin wrinkling (HP:0100678)1.59311212
173Abnormality of the aortic arch (HP:0012303)1.59245715
174Thoracic kyphosis (HP:0002942)1.58970978
175Vertebral arch anomaly (HP:0008438)1.57924361
176Abnormality of the radial head (HP:0003995)1.57754627
177Hyperthyroidism (HP:0000836)1.56698474
178Atelectasis (HP:0100750)1.56185847
179Back pain (HP:0003418)1.55693300
180Persistence of primary teeth (HP:0006335)1.54860348
181Reticulocytosis (HP:0001923)1.54845319
182Dilatation of the ascending aorta (HP:0005111)1.54495429
183Nonimmune hydrops fetalis (HP:0001790)1.53789154
184Lymphangioma (HP:0100764)1.51394855
185Mildly elevated creatine phosphokinase (HP:0008180)1.51390713
186High anterior hairline (HP:0009890)1.51243257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.58944028
2SMG13.81722594
3MAP3K93.79093322
4NTRK33.61456255
5PRKD33.03325977
6CDK123.01772160
7SIK12.93915613
8MARK12.74406175
9DAPK22.70153660
10IRAK32.68285575
11KSR22.48323732
12PAK62.38468033
13MAP3K42.37906316
14ERN12.22007796
15SIK22.18238755
16NTRK22.07112139
17TYRO32.00316259
18MINK11.99433602
19CAMKK11.83381205
20FGFR41.76537124
21TRIB31.71495536
22KSR11.69777688
23RIPK41.59566900
24TTN1.59052637
25NTRK11.57178669
26ICK1.55742273
27TAOK11.55168290
28MAP3K21.53950871
29CDK51.46178849
30EPHA21.44851597
31RIPK11.41318221
32UHMK11.39974791
33MAP2K31.39392525
34DAPK11.34446116
35PTK2B1.31146885
36MAP2K41.30659447
37PKN21.28527790
38MARK21.26368575
39MTOR1.24884599
40STK111.21196689
41CAMK1G1.20813157
42ALK1.19263171
43PNCK1.18053770
44NME21.15981775
45PAK41.15845016
46EEF2K1.14737235
47DMPK1.12222921
48STK381.11197481
49MAP3K111.11107225
50TAOK21.09902239
51RET1.08598587
52EPHB11.05867781
53PRKCH1.02834315
54CDK191.00101592
55IRAK20.99478248
56MAP2K70.99227852
57GRK50.97817954
58PDGFRA0.96836037
59FES0.95517428
60IRAK40.92879636
61PDPK10.88447485
62MAPK130.88067960
63BRAF0.87739077
64CDK150.87393025
65TESK20.87373948
66PHKG10.86854276
67PHKG20.86854276
68RPS6KC10.86696373
69RPS6KL10.86696373
70PDK10.85767388
71CDK180.83715522
72PAK30.83472926
73CAMK10.83347850
74MAP3K130.82516829
75TESK10.82473196
76CDK40.81376830
77MAP2K20.79907703
78PRPF4B0.77298844
79CDK11A0.76075159
80PRKCG0.75858079
81CDK140.75310127
82RAF10.74792487
83MAP3K80.74470068
84KDR0.73365112
85MAP3K30.72830491
86CDK70.72106388
87HIPK20.71315882
88LMTK20.70724450
89MST1R0.69827208
90PLK20.67378030
91SIK30.64845426
92CDC42BPA0.64064594
93BRD40.63137745
94FGR0.63066111
95RPS6KA60.62937553
96ARAF0.62452336
97BMX0.61441354
98CAMK2A0.60668013
99MAP3K100.60579259
100EPHB20.60065566
101ILK0.59394482
102TNIK0.59285454
103LATS20.59017789
104MAPK110.58805064
105MAP4K10.58030336
106DAPK30.57667386
107GRK60.57540913
108MAP3K70.56736726
109DYRK1A0.56348683
110FYN0.56053135
111MAP3K10.55158691
112CAMK2B0.54921674
113MAP3K60.54767708
114DDR20.54351259
115ZAP700.53681592
116CAMK40.53434966
117LRRK20.52666144
118PRKD20.52547828
119FGFR20.52184784
120PKN10.51529801
121CAMK1D0.47233502
122RPS6KB20.47062619
123SGK10.46759250
124PTK60.46480627
125PTK20.46251717
126RPS6KA10.44698169
127RPS6KA20.44694290
128RPS6KA30.44540393
129PRKG20.44539545
130PRKD10.43905948
131DYRK1B0.43561798
132PRKCZ0.43522636
133CSNK1G20.43178979
134CLK10.42889337
135TBK10.42265308
136MAPK100.41450706
137FER0.41304464
138CSK0.40992076
139MET0.40954011
140ROCK20.40331452
141CAMKK20.39671207
142PAK20.39470496
143SCYL20.38968581
144MAP2K10.38946400
145SGK2230.38547120
146SGK4940.38547120
147TNK20.38045676
148SGK30.36970456
149MAPK120.36200914
150PDGFRB0.36180361
151CDK90.35553767
152AURKA0.32420516
153PAK10.31141689
154CDK60.29106146

Predicted pathways (KEGG)

RankGene SetZ-score
1Long-term potentiation_Homo sapiens_hsa047202.54137420
2Nicotine addiction_Homo sapiens_hsa050332.52207373
3Circadian entrainment_Homo sapiens_hsa047132.47192494
4Synaptic vesicle cycle_Homo sapiens_hsa047212.45340890
5Olfactory transduction_Homo sapiens_hsa047402.43525206
6Glutamatergic synapse_Homo sapiens_hsa047242.31406046
7Notch signaling pathway_Homo sapiens_hsa043302.26634335
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.24121175
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22564856
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17565872
11Amphetamine addiction_Homo sapiens_hsa050312.16438325
12Morphine addiction_Homo sapiens_hsa050322.10484227
13GABAergic synapse_Homo sapiens_hsa047272.09078918
14Acute myeloid leukemia_Homo sapiens_hsa052212.04023006
15Salivary secretion_Homo sapiens_hsa049702.00649468
16Dopaminergic synapse_Homo sapiens_hsa047281.96511061
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.91040034
18Bladder cancer_Homo sapiens_hsa052191.88057459
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.85483003
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84820272
21Gastric acid secretion_Homo sapiens_hsa049711.84241774
22Insulin secretion_Homo sapiens_hsa049111.82831766
23Cholinergic synapse_Homo sapiens_hsa047251.78264481
24Oxytocin signaling pathway_Homo sapiens_hsa049211.69883790
25Pancreatic cancer_Homo sapiens_hsa052121.66267934
26Renin secretion_Homo sapiens_hsa049241.65674127
27Thyroid cancer_Homo sapiens_hsa052161.54867343
28GnRH signaling pathway_Homo sapiens_hsa049121.53502927
29Other glycan degradation_Homo sapiens_hsa005111.49622909
30Cocaine addiction_Homo sapiens_hsa050301.47448016
31Long-term depression_Homo sapiens_hsa047301.45153569
32Taste transduction_Homo sapiens_hsa047421.42490305
33Gap junction_Homo sapiens_hsa045401.41758940
34Calcium signaling pathway_Homo sapiens_hsa040201.41380548
35Axon guidance_Homo sapiens_hsa043601.41263031
36Estrogen signaling pathway_Homo sapiens_hsa049151.39837608
37Glioma_Homo sapiens_hsa052141.39298753
38B cell receptor signaling pathway_Homo sapiens_hsa046621.38838767
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32865984
40Type II diabetes mellitus_Homo sapiens_hsa049301.30915187
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30111112
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25070980
43cAMP signaling pathway_Homo sapiens_hsa040241.23545615
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22931530
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.22322673
46cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21411405
47Serotonergic synapse_Homo sapiens_hsa047261.19041085
48Melanogenesis_Homo sapiens_hsa049161.17180964
49Phospholipase D signaling pathway_Homo sapiens_hsa040721.14688171
50VEGF signaling pathway_Homo sapiens_hsa043701.13657075
51MicroRNAs in cancer_Homo sapiens_hsa052061.13643773
52Adherens junction_Homo sapiens_hsa045201.12328176
53Pentose phosphate pathway_Homo sapiens_hsa000301.11236366
54ErbB signaling pathway_Homo sapiens_hsa040121.11214152
55Dorso-ventral axis formation_Homo sapiens_hsa043201.10749740
56Prostate cancer_Homo sapiens_hsa052151.10735827
57Small cell lung cancer_Homo sapiens_hsa052221.10231431
58Dilated cardiomyopathy_Homo sapiens_hsa054141.06636697
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.02955961
60AMPK signaling pathway_Homo sapiens_hsa041521.02350365
61Vascular smooth muscle contraction_Homo sapiens_hsa042701.01241761
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99971649
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.99102212
64Osteoclast differentiation_Homo sapiens_hsa043800.96826695
65Hepatitis B_Homo sapiens_hsa051610.96799093
66Fructose and mannose metabolism_Homo sapiens_hsa000510.94700116
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93662772
68Amoebiasis_Homo sapiens_hsa051460.93633687
69Oocyte meiosis_Homo sapiens_hsa041140.93233290
70Shigellosis_Homo sapiens_hsa051310.92353886
71Prolactin signaling pathway_Homo sapiens_hsa049170.92152810
72Apoptosis_Homo sapiens_hsa042100.90753455
73mTOR signaling pathway_Homo sapiens_hsa041500.89625406
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88940094
75Galactose metabolism_Homo sapiens_hsa000520.88253086
76Choline metabolism in cancer_Homo sapiens_hsa052310.86551202
77Rap1 signaling pathway_Homo sapiens_hsa040150.86526261
78Viral carcinogenesis_Homo sapiens_hsa052030.85717068
79Hepatitis C_Homo sapiens_hsa051600.85341335
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84815971
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84684148
82Pancreatic secretion_Homo sapiens_hsa049720.83487080
83Non-small cell lung cancer_Homo sapiens_hsa052230.82722050
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82247071
85MAPK signaling pathway_Homo sapiens_hsa040100.81993381
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81328926
87Renal cell carcinoma_Homo sapiens_hsa052110.80851161
88HTLV-I infection_Homo sapiens_hsa051660.80136357
89Cardiac muscle contraction_Homo sapiens_hsa042600.79369525
90Nitrogen metabolism_Homo sapiens_hsa009100.79240982
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.78568104
92ECM-receptor interaction_Homo sapiens_hsa045120.78161563
93Glucagon signaling pathway_Homo sapiens_hsa049220.77769988
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77569145
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.77221399
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76527408
97Salmonella infection_Homo sapiens_hsa051320.76293659
98T cell receptor signaling pathway_Homo sapiens_hsa046600.76068069
99Thyroid hormone synthesis_Homo sapiens_hsa049180.75955997
100Collecting duct acid secretion_Homo sapiens_hsa049660.75944904
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.75772675
102Lysine degradation_Homo sapiens_hsa003100.75165278
103Biosynthesis of amino acids_Homo sapiens_hsa012300.73667457
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73475451
105HIF-1 signaling pathway_Homo sapiens_hsa040660.72896989
106TNF signaling pathway_Homo sapiens_hsa046680.72397003
107Endometrial cancer_Homo sapiens_hsa052130.71182394
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70936588
109Endocytosis_Homo sapiens_hsa041440.70846898
110Pathways in cancer_Homo sapiens_hsa052000.69742701
111Alcoholism_Homo sapiens_hsa050340.68826866
112Basal cell carcinoma_Homo sapiens_hsa052170.68702582
113Insulin resistance_Homo sapiens_hsa049310.68418386
114Ras signaling pathway_Homo sapiens_hsa040140.68115750
115mRNA surveillance pathway_Homo sapiens_hsa030150.65724578
116Toxoplasmosis_Homo sapiens_hsa051450.65243832
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.64698676
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64119141
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63331660
120Sulfur relay system_Homo sapiens_hsa041220.63283361
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63236326
122Influenza A_Homo sapiens_hsa051640.62755961
123Vibrio cholerae infection_Homo sapiens_hsa051100.62557193
124Inositol phosphate metabolism_Homo sapiens_hsa005620.61186789
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61111359
126Wnt signaling pathway_Homo sapiens_hsa043100.61087350
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60306279
128Melanoma_Homo sapiens_hsa052180.59923471
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.58789483
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57846224
131Colorectal cancer_Homo sapiens_hsa052100.57451952
132DNA replication_Homo sapiens_hsa030300.56541871
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55540076
134FoxO signaling pathway_Homo sapiens_hsa040680.54980062
135Insulin signaling pathway_Homo sapiens_hsa049100.54787556
136Chemokine signaling pathway_Homo sapiens_hsa040620.54771518
137Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54548271
138Leishmaniasis_Homo sapiens_hsa051400.54196364
139Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54189934
140Platelet activation_Homo sapiens_hsa046110.53610771
141Hedgehog signaling pathway_Homo sapiens_hsa043400.52573021
142Tight junction_Homo sapiens_hsa045300.51986987
143Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51305329
144Chronic myeloid leukemia_Homo sapiens_hsa052200.50158866
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49272062
146Focal adhesion_Homo sapiens_hsa045100.46923283
147Proteoglycans in cancer_Homo sapiens_hsa052050.46898590
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46246382
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43857962
150Prion diseases_Homo sapiens_hsa050200.43528491
151Hippo signaling pathway_Homo sapiens_hsa043900.41834542
152Bile secretion_Homo sapiens_hsa049760.40631781

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